id sid tid token lemma pos cord-024076-q9fw7ch1 1 1 key key NNP cord-024076-q9fw7ch1 1 2 : : : cord-024076-q9fw7ch1 1 3 cord-024076-q9fw7ch1 cord-024076-q9fw7ch1 JJ cord-024076-q9fw7ch1 1 4 authors author NNS cord-024076-q9fw7ch1 1 5 : : : cord-024076-q9fw7ch1 1 6 Manga Manga NNP cord-024076-q9fw7ch1 1 7 , , , cord-024076-q9fw7ch1 1 8 Pravin Pravin NNP cord-024076-q9fw7ch1 1 9 title title NN cord-024076-q9fw7ch1 1 10 : : : cord-024076-q9fw7ch1 1 11 Should Should MD cord-024076-q9fw7ch1 1 12 ACE ACE NNP cord-024076-q9fw7ch1 1 13 Inhibitors Inhibitors NNP cord-024076-q9fw7ch1 1 14 and and CC cord-024076-q9fw7ch1 1 15 Angiotensin Angiotensin NNP cord-024076-q9fw7ch1 1 16 Receptor Receptor NNP cord-024076-q9fw7ch1 1 17 Blockers Blockers NNP cord-024076-q9fw7ch1 2 1 Be be VB cord-024076-q9fw7ch1 2 2 Withdrawn withdraw VBN cord-024076-q9fw7ch1 2 3 in in IN cord-024076-q9fw7ch1 2 4 the the DT cord-024076-q9fw7ch1 2 5 Current current JJ cord-024076-q9fw7ch1 2 6 Setting setting NN cord-024076-q9fw7ch1 2 7 of of IN cord-024076-q9fw7ch1 2 8 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 2 9 Infection infection NN cord-024076-q9fw7ch1 2 10 ? ? . cord-024076-q9fw7ch1 3 1 date date NN cord-024076-q9fw7ch1 3 2 : : : cord-024076-q9fw7ch1 3 3 2020 2020 CD cord-024076-q9fw7ch1 3 4 - - HYPH cord-024076-q9fw7ch1 3 5 04 04 CD cord-024076-q9fw7ch1 3 6 - - SYM cord-024076-q9fw7ch1 3 7 17 17 CD cord-024076-q9fw7ch1 3 8 journal journal NN cord-024076-q9fw7ch1 3 9 : : : cord-024076-q9fw7ch1 4 1 nan nan NNP cord-024076-q9fw7ch1 4 2 DOI DOI NNP cord-024076-q9fw7ch1 4 3 : : : cord-024076-q9fw7ch1 5 1 10.18772/26180197.2020.v2nsia4 10.18772/26180197.2020.v2nsia4 LS cord-024076-q9fw7ch1 5 2 sha sha NNP cord-024076-q9fw7ch1 5 3 : : : cord-024076-q9fw7ch1 6 1 2e28fd98d052f849f330655822397d5f178f77e2 2e28fd98d052f849f330655822397d5f178f77e2 CD cord-024076-q9fw7ch1 6 2 doc_id doc_id CD cord-024076-q9fw7ch1 6 3 : : : cord-024076-q9fw7ch1 6 4 24076 24076 CD cord-024076-q9fw7ch1 7 1 cord_uid cord_uid NN cord-024076-q9fw7ch1 7 2 : : : cord-024076-q9fw7ch1 8 1 q9fw7ch1 q9fw7ch1 NNP cord-024076-q9fw7ch1 9 1 nan nan NNP cord-024076-q9fw7ch1 10 1 The the DT cord-024076-q9fw7ch1 10 2 reports report NNS cord-024076-q9fw7ch1 10 3 urging urge VBG cord-024076-q9fw7ch1 10 4 caution caution NN cord-024076-q9fw7ch1 10 5 in in IN cord-024076-q9fw7ch1 10 6 the the DT cord-024076-q9fw7ch1 10 7 use use NN cord-024076-q9fw7ch1 10 8 of of IN cord-024076-q9fw7ch1 10 9 ACE ace NN cord-024076-q9fw7ch1 10 10 inhibitors inhibitor NNS cord-024076-q9fw7ch1 10 11 and and CC cord-024076-q9fw7ch1 10 12 ARBs arb NNS cord-024076-q9fw7ch1 10 13 for for IN cord-024076-q9fw7ch1 10 14 hypertension hypertension NN cord-024076-q9fw7ch1 10 15 , , , cord-024076-q9fw7ch1 10 16 diabetes diabetes NN cord-024076-q9fw7ch1 10 17 and and CC cord-024076-q9fw7ch1 10 18 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 10 19 disease disease NN cord-024076-q9fw7ch1 10 20 are be VBP cord-024076-q9fw7ch1 10 21 based base VBN cord-024076-q9fw7ch1 10 22 on on IN cord-024076-q9fw7ch1 10 23 laboratory laboratory NN cord-024076-q9fw7ch1 10 24 data datum NNS cord-024076-q9fw7ch1 10 25 which which WDT cord-024076-q9fw7ch1 10 26 found find VBD cord-024076-q9fw7ch1 10 27 that that IN cord-024076-q9fw7ch1 10 28 SARS SARS NNP cord-024076-q9fw7ch1 10 29 - - HYPH cord-024076-q9fw7ch1 10 30 CoV CoV NNP cord-024076-q9fw7ch1 10 31 and and CC cord-024076-q9fw7ch1 10 32 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 10 33 virus virus NN cord-024076-q9fw7ch1 10 34 binds bind VBZ cord-024076-q9fw7ch1 10 35 to to IN cord-024076-q9fw7ch1 10 36 ACE ace NN cord-024076-q9fw7ch1 10 37 2 2 CD cord-024076-q9fw7ch1 10 38 receptor receptor NN cord-024076-q9fw7ch1 10 39 which which WDT cord-024076-q9fw7ch1 10 40 is be VBZ cord-024076-q9fw7ch1 10 41 found find VBN cord-024076-q9fw7ch1 10 42 in in IN cord-024076-q9fw7ch1 10 43 the the DT cord-024076-q9fw7ch1 10 44 epithelial epithelial JJ cord-024076-q9fw7ch1 10 45 cells cell NNS cord-024076-q9fw7ch1 10 46 of of IN cord-024076-q9fw7ch1 10 47 the the DT cord-024076-q9fw7ch1 10 48 lung lung NN cord-024076-q9fw7ch1 10 49 , , , cord-024076-q9fw7ch1 10 50 kidney kidney NN cord-024076-q9fw7ch1 10 51 , , , cord-024076-q9fw7ch1 10 52 intestine intestine NN cord-024076-q9fw7ch1 10 53 and and CC cord-024076-q9fw7ch1 10 54 blood blood NN cord-024076-q9fw7ch1 10 55 vessels vessel NNS cord-024076-q9fw7ch1 10 56 . . . cord-024076-q9fw7ch1 11 1 ( ( -LRB- cord-024076-q9fw7ch1 11 2 4 4 CD cord-024076-q9fw7ch1 11 3 , , , cord-024076-q9fw7ch1 11 4 5 5 CD cord-024076-q9fw7ch1 11 5 ) ) -RRB- cord-024076-q9fw7ch1 12 1 The the DT cord-024076-q9fw7ch1 12 2 ACE ace NN cord-024076-q9fw7ch1 12 3 2 2 CD cord-024076-q9fw7ch1 12 4 is be VBZ cord-024076-q9fw7ch1 12 5 an an DT cord-024076-q9fw7ch1 12 6 integral integral JJ cord-024076-q9fw7ch1 12 7 protein protein NN cord-024076-q9fw7ch1 12 8 and and CC cord-024076-q9fw7ch1 12 9 contributes contribute VBZ cord-024076-q9fw7ch1 12 10 to to IN cord-024076-q9fw7ch1 12 11 a a DT cord-024076-q9fw7ch1 12 12 host host NN cord-024076-q9fw7ch1 12 13 of of IN cord-024076-q9fw7ch1 12 14 physiologic physiologic JJ cord-024076-q9fw7ch1 12 15 functions function NNS cord-024076-q9fw7ch1 12 16 and and CC cord-024076-q9fw7ch1 12 17 is be VBZ cord-024076-q9fw7ch1 12 18 highly highly RB cord-024076-q9fw7ch1 12 19 expressed express VBN cord-024076-q9fw7ch1 12 20 in in IN cord-024076-q9fw7ch1 12 21 alveolar alveolar JJ cord-024076-q9fw7ch1 12 22 cells cell NNS cord-024076-q9fw7ch1 12 23 of of IN cord-024076-q9fw7ch1 12 24 the the DT cord-024076-q9fw7ch1 12 25 lungs lung NNS cord-024076-q9fw7ch1 12 26 , , , cord-024076-q9fw7ch1 12 27 providing provide VBG cord-024076-q9fw7ch1 12 28 the the DT cord-024076-q9fw7ch1 12 29 main main JJ cord-024076-q9fw7ch1 12 30 entry entry NN cord-024076-q9fw7ch1 12 31 site site NN cord-024076-q9fw7ch1 12 32 for for IN cord-024076-q9fw7ch1 12 33 the the DT cord-024076-q9fw7ch1 12 34 virus virus NN cord-024076-q9fw7ch1 12 35 into into IN cord-024076-q9fw7ch1 12 36 human human JJ cord-024076-q9fw7ch1 12 37 hosts host NNS cord-024076-q9fw7ch1 12 38 . . . cord-024076-q9fw7ch1 13 1 ( ( -LRB- cord-024076-q9fw7ch1 13 2 5 5 LS cord-024076-q9fw7ch1 13 3 ) ) -RRB- cord-024076-q9fw7ch1 14 1 Once once IN cord-024076-q9fw7ch1 14 2 the the DT cord-024076-q9fw7ch1 14 3 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 14 4 virus virus NN cord-024076-q9fw7ch1 14 5 binds bind VBZ cord-024076-q9fw7ch1 14 6 to to IN cord-024076-q9fw7ch1 14 7 ACE ace NN cord-024076-q9fw7ch1 14 8 2 2 CD cord-024076-q9fw7ch1 14 9 and and CC cord-024076-q9fw7ch1 14 10 gains gain NNS cord-024076-q9fw7ch1 14 11 entry entry NN cord-024076-q9fw7ch1 14 12 , , , cord-024076-q9fw7ch1 14 13 it -PRON- PRP cord-024076-q9fw7ch1 14 14 subsequently subsequently RB cord-024076-q9fw7ch1 14 15 downregulates downregulate VBZ cord-024076-q9fw7ch1 14 16 ACE ace NN cord-024076-q9fw7ch1 14 17 2 2 CD cord-024076-q9fw7ch1 14 18 expression expression NN cord-024076-q9fw7ch1 14 19 . . . cord-024076-q9fw7ch1 15 1 It -PRON- PRP cord-024076-q9fw7ch1 15 2 is be VBZ cord-024076-q9fw7ch1 15 3 postulated postulate VBN cord-024076-q9fw7ch1 15 4 that that IN cord-024076-q9fw7ch1 15 5 this this DT cord-024076-q9fw7ch1 15 6 may may MD cord-024076-q9fw7ch1 15 7 lead lead VB cord-024076-q9fw7ch1 15 8 to to IN cord-024076-q9fw7ch1 15 9 unopposed unopposed JJ cord-024076-q9fw7ch1 15 10 angiotensin angiotensin NN cord-024076-q9fw7ch1 15 11 II II NNP cord-024076-q9fw7ch1 15 12 activity activity NN cord-024076-q9fw7ch1 15 13 and and CC cord-024076-q9fw7ch1 15 14 renin renin NN cord-024076-q9fw7ch1 15 15 - - HYPH cord-024076-q9fw7ch1 15 16 angiotensin angiotensin NN cord-024076-q9fw7ch1 15 17 - - HYPH cord-024076-q9fw7ch1 15 18 aldosterone aldosterone NN cord-024076-q9fw7ch1 15 19 - - HYPH cord-024076-q9fw7ch1 15 20 system system NN cord-024076-q9fw7ch1 15 21 ( ( -LRB- cord-024076-q9fw7ch1 15 22 RAAS RAAS NNP cord-024076-q9fw7ch1 15 23 ) ) -RRB- cord-024076-q9fw7ch1 15 24 activation activation NN cord-024076-q9fw7ch1 15 25 , , , cord-024076-q9fw7ch1 15 26 leading lead VBG cord-024076-q9fw7ch1 15 27 to to IN cord-024076-q9fw7ch1 15 28 neutrophil neutrophil NN cord-024076-q9fw7ch1 15 29 infiltration infiltration NN cord-024076-q9fw7ch1 15 30 into into IN cord-024076-q9fw7ch1 15 31 the the DT cord-024076-q9fw7ch1 15 32 lungs lung NNS cord-024076-q9fw7ch1 15 33 and and CC cord-024076-q9fw7ch1 15 34 lung lung NN cord-024076-q9fw7ch1 15 35 injury injury NN cord-024076-q9fw7ch1 15 36 . . . cord-024076-q9fw7ch1 16 1 ( ( -LRB- cord-024076-q9fw7ch1 16 2 6 6 CD cord-024076-q9fw7ch1 16 3 ) ) -RRB- cord-024076-q9fw7ch1 17 1 However however RB cord-024076-q9fw7ch1 17 2 , , , cord-024076-q9fw7ch1 17 3 ACE ACE NNP cord-024076-q9fw7ch1 17 4 2 2 CD cord-024076-q9fw7ch1 17 5 also also RB cord-024076-q9fw7ch1 17 6 has have VBZ cord-024076-q9fw7ch1 17 7 potential potential JJ cord-024076-q9fw7ch1 17 8 protective protective JJ cord-024076-q9fw7ch1 17 9 effects effect NNS cord-024076-q9fw7ch1 17 10 in in IN cord-024076-q9fw7ch1 17 11 that that IN cord-024076-q9fw7ch1 17 12 it -PRON- PRP cord-024076-q9fw7ch1 17 13 counters counter VBZ cord-024076-q9fw7ch1 17 14 the the DT cord-024076-q9fw7ch1 17 15 effects effect NNS cord-024076-q9fw7ch1 17 16 of of IN cord-024076-q9fw7ch1 17 17 angiotensin angiotensin NN cord-024076-q9fw7ch1 17 18 II II NNP cord-024076-q9fw7ch1 17 19 via via IN cord-024076-q9fw7ch1 17 20 angiotensin angiotensin NN cord-024076-q9fw7ch1 17 21 1 1 CD cord-024076-q9fw7ch1 17 22 receptor receptor NN cord-024076-q9fw7ch1 17 23 activation activation NN cord-024076-q9fw7ch1 17 24 , , , cord-024076-q9fw7ch1 17 25 by by IN cord-024076-q9fw7ch1 17 26 promoting promote VBG cord-024076-q9fw7ch1 17 27 the the DT cord-024076-q9fw7ch1 17 28 conversion conversion NN cord-024076-q9fw7ch1 17 29 of of IN cord-024076-q9fw7ch1 17 30 angiotensin angiotensin NN cord-024076-q9fw7ch1 17 31 II II NNP cord-024076-q9fw7ch1 17 32 to to IN cord-024076-q9fw7ch1 17 33 angiotensin angiotensin NN cord-024076-q9fw7ch1 17 34 1 1 CD cord-024076-q9fw7ch1 17 35 - - SYM cord-024076-q9fw7ch1 17 36 7 7 CD cord-024076-q9fw7ch1 17 37 , , , cord-024076-q9fw7ch1 17 38 which which WDT cord-024076-q9fw7ch1 17 39 in in IN cord-024076-q9fw7ch1 17 40 turn turn NN cord-024076-q9fw7ch1 17 41 modestly modestly RB cord-024076-q9fw7ch1 17 42 lowers lower VBZ cord-024076-q9fw7ch1 17 43 blood blood NN cord-024076-q9fw7ch1 17 44 pressure pressure NN cord-024076-q9fw7ch1 17 45 through through IN cord-024076-q9fw7ch1 17 46 vasodilatation vasodilatation NN cord-024076-q9fw7ch1 17 47 and and CC cord-024076-q9fw7ch1 17 48 increases increase VBZ cord-024076-q9fw7ch1 17 49 renal renal JJ cord-024076-q9fw7ch1 17 50 excretion excretion NN cord-024076-q9fw7ch1 17 51 of of IN cord-024076-q9fw7ch1 17 52 sodium sodium NN cord-024076-q9fw7ch1 17 53 and and CC cord-024076-q9fw7ch1 17 54 water water NN cord-024076-q9fw7ch1 17 55 . . . cord-024076-q9fw7ch1 18 1 ACE ace NN cord-024076-q9fw7ch1 18 2 2 2 CD cord-024076-q9fw7ch1 18 3 may may MD cord-024076-q9fw7ch1 18 4 also also RB cord-024076-q9fw7ch1 18 5 attenuate attenuate VB cord-024076-q9fw7ch1 18 6 inflammation inflammation NN cord-024076-q9fw7ch1 18 7 through through IN cord-024076-q9fw7ch1 18 8 the the DT cord-024076-q9fw7ch1 18 9 activation activation NN cord-024076-q9fw7ch1 18 10 of of IN cord-024076-q9fw7ch1 18 11 nitric nitric JJ cord-024076-q9fw7ch1 18 12 oxide oxide NN cord-024076-q9fw7ch1 18 13 pathways pathway NNS cord-024076-q9fw7ch1 18 14 . . . cord-024076-q9fw7ch1 19 1 In in IN cord-024076-q9fw7ch1 19 2 some some DT cord-024076-q9fw7ch1 19 3 experimental experimental JJ cord-024076-q9fw7ch1 19 4 studies study NNS cord-024076-q9fw7ch1 19 5 with with IN cord-024076-q9fw7ch1 19 6 animal animal NN cord-024076-q9fw7ch1 19 7 models model NNS cord-024076-q9fw7ch1 19 8 , , , cord-024076-q9fw7ch1 19 9 it -PRON- PRP cord-024076-q9fw7ch1 19 10 has have VBZ cord-024076-q9fw7ch1 19 11 been be VBN cord-024076-q9fw7ch1 19 12 shown show VBN cord-024076-q9fw7ch1 19 13 that that IN cord-024076-q9fw7ch1 19 14 there there EX cord-024076-q9fw7ch1 19 15 is be VBZ cord-024076-q9fw7ch1 19 16 increased increase VBN cord-024076-q9fw7ch1 19 17 expression expression NN cord-024076-q9fw7ch1 19 18 and and CC cord-024076-q9fw7ch1 19 19 activity activity NN cord-024076-q9fw7ch1 19 20 of of IN cord-024076-q9fw7ch1 19 21 ACE ace NN cord-024076-q9fw7ch1 19 22 2 2 CD cord-024076-q9fw7ch1 19 23 in in IN cord-024076-q9fw7ch1 19 24 the the DT cord-024076-q9fw7ch1 19 25 heart heart NN cord-024076-q9fw7ch1 19 26 and and CC cord-024076-q9fw7ch1 19 27 brain brain NN cord-024076-q9fw7ch1 19 28 after after IN cord-024076-q9fw7ch1 19 29 treatment treatment NN cord-024076-q9fw7ch1 19 30 with with IN cord-024076-q9fw7ch1 19 31 ACE ACE NNP cord-024076-q9fw7ch1 19 32 inhibitors inhibitor NNS cord-024076-q9fw7ch1 19 33 and and CC cord-024076-q9fw7ch1 19 34 ARBs.(7 arbs.(7 NN cord-024076-q9fw7ch1 19 35 ) ) -RRB- cord-024076-q9fw7ch1 20 1 Furthermore furthermore RB cord-024076-q9fw7ch1 20 2 , , , cord-024076-q9fw7ch1 20 3 the the DT cord-024076-q9fw7ch1 20 4 upregulation upregulation NN cord-024076-q9fw7ch1 20 5 of of IN cord-024076-q9fw7ch1 20 6 ACE ace NN cord-024076-q9fw7ch1 20 7 2 2 CD cord-024076-q9fw7ch1 20 8 in in IN cord-024076-q9fw7ch1 20 9 humans human NNS cord-024076-q9fw7ch1 20 10 is be VBZ cord-024076-q9fw7ch1 20 11 supported support VBN cord-024076-q9fw7ch1 20 12 by by IN cord-024076-q9fw7ch1 20 13 recent recent JJ cord-024076-q9fw7ch1 20 14 evidence evidence NN cord-024076-q9fw7ch1 20 15 showing show VBG cord-024076-q9fw7ch1 20 16 an an DT cord-024076-q9fw7ch1 20 17 increased increase VBN cord-024076-q9fw7ch1 20 18 secretion secretion NN cord-024076-q9fw7ch1 20 19 of of IN cord-024076-q9fw7ch1 20 20 ACE ace NN cord-024076-q9fw7ch1 20 21 2 2 CD cord-024076-q9fw7ch1 20 22 in in IN cord-024076-q9fw7ch1 20 23 the the DT cord-024076-q9fw7ch1 20 24 urine urine NN cord-024076-q9fw7ch1 20 25 of of IN cord-024076-q9fw7ch1 20 26 hypertensive hypertensive JJ cord-024076-q9fw7ch1 20 27 patients patient NNS cord-024076-q9fw7ch1 20 28 treated treat VBN cord-024076-q9fw7ch1 20 29 with with IN cord-024076-q9fw7ch1 20 30 olmesartan olmesartan NNP cord-024076-q9fw7ch1 20 31 , , , cord-024076-q9fw7ch1 20 32 an an DT cord-024076-q9fw7ch1 20 33 ARB arb NN cord-024076-q9fw7ch1 20 34 . . . cord-024076-q9fw7ch1 21 1 ( ( -LRB- cord-024076-q9fw7ch1 21 2 8) 8) NNP cord-024076-q9fw7ch1 22 1 Although although IN cord-024076-q9fw7ch1 22 2 ACE ace NN cord-024076-q9fw7ch1 22 3 2 2 CD cord-024076-q9fw7ch1 22 4 receptor receptor NN cord-024076-q9fw7ch1 22 5 upregulation upregulation NN cord-024076-q9fw7ch1 22 6 may may MD cord-024076-q9fw7ch1 22 7 be be VB cord-024076-q9fw7ch1 22 8 induced induce VBN cord-024076-q9fw7ch1 22 9 by by IN cord-024076-q9fw7ch1 22 10 ACE ACE NNP cord-024076-q9fw7ch1 22 11 inhibitors inhibitor NNS cord-024076-q9fw7ch1 22 12 and and CC cord-024076-q9fw7ch1 22 13 ARB arb NN cord-024076-q9fw7ch1 22 14 treatment treatment NN cord-024076-q9fw7ch1 22 15 and and CC cord-024076-q9fw7ch1 22 16 hence hence RB cord-024076-q9fw7ch1 22 17 a a DT cord-024076-q9fw7ch1 22 18 theoretical theoretical JJ cord-024076-q9fw7ch1 22 19 risk risk NN cord-024076-q9fw7ch1 22 20 of of IN cord-024076-q9fw7ch1 22 21 increased increase VBN cord-024076-q9fw7ch1 22 22 susceptibility susceptibility NN cord-024076-q9fw7ch1 22 23 to to IN cord-024076-q9fw7ch1 22 24 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 22 25 infection infection NN cord-024076-q9fw7ch1 22 26 , , , cord-024076-q9fw7ch1 22 27 currently currently RB cord-024076-q9fw7ch1 22 28 there there EX cord-024076-q9fw7ch1 22 29 is be VBZ cord-024076-q9fw7ch1 22 30 no no DT cord-024076-q9fw7ch1 22 31 data data NN cord-024076-q9fw7ch1 22 32 that that WDT cord-024076-q9fw7ch1 22 33 has have VBZ cord-024076-q9fw7ch1 22 34 demonstrated demonstrate VBN cord-024076-q9fw7ch1 22 35 a a DT cord-024076-q9fw7ch1 22 36 definitive definitive JJ cord-024076-q9fw7ch1 22 37 causal causal JJ cord-024076-q9fw7ch1 22 38 relationship relationship NN cord-024076-q9fw7ch1 22 39 between between IN cord-024076-q9fw7ch1 22 40 ACE ace NN cord-024076-q9fw7ch1 22 41 2 2 CD cord-024076-q9fw7ch1 22 42 activity activity NN cord-024076-q9fw7ch1 22 43 and and CC cord-024076-q9fw7ch1 22 44 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 22 45 mortality mortality NN cord-024076-q9fw7ch1 22 46 . . . cord-024076-q9fw7ch1 23 1 Interestingly interestingly RB cord-024076-q9fw7ch1 23 2 , , , cord-024076-q9fw7ch1 23 3 ACE ACE NNP cord-024076-q9fw7ch1 23 4 2 2 CD cord-024076-q9fw7ch1 23 5 and and CC cord-024076-q9fw7ch1 23 6 angiotensin angiotensin NN cord-024076-q9fw7ch1 23 7 1 1 CD cord-024076-q9fw7ch1 23 8 - - SYM cord-024076-q9fw7ch1 23 9 7 7 CD cord-024076-q9fw7ch1 23 10 may may MD cord-024076-q9fw7ch1 23 11 in in IN cord-024076-q9fw7ch1 23 12 fact fact NN cord-024076-q9fw7ch1 23 13 have have VB cord-024076-q9fw7ch1 23 14 a a DT cord-024076-q9fw7ch1 23 15 salutatory salutatory JJ cord-024076-q9fw7ch1 23 16 role role NN cord-024076-q9fw7ch1 23 17 in in IN cord-024076-q9fw7ch1 23 18 the the DT cord-024076-q9fw7ch1 23 19 lungs lung NNS cord-024076-q9fw7ch1 23 20 since since IN cord-024076-q9fw7ch1 23 21 it -PRON- PRP cord-024076-q9fw7ch1 23 22 has have VBZ cord-024076-q9fw7ch1 23 23 been be VBN cord-024076-q9fw7ch1 23 24 found find VBN cord-024076-q9fw7ch1 23 25 to to TO cord-024076-q9fw7ch1 23 26 be be VB cord-024076-q9fw7ch1 23 27 protective protective JJ cord-024076-q9fw7ch1 23 28 in in IN cord-024076-q9fw7ch1 23 29 a a DT cord-024076-q9fw7ch1 23 30 number number NN cord-024076-q9fw7ch1 23 31 of of IN cord-024076-q9fw7ch1 23 32 lung lung NN cord-024076-q9fw7ch1 23 33 injury injury NN cord-024076-q9fw7ch1 23 34 models model NNS cord-024076-q9fw7ch1 23 35 . . . cord-024076-q9fw7ch1 24 1 In in IN cord-024076-q9fw7ch1 24 2 a a DT cord-024076-q9fw7ch1 24 3 mouse mouse NN cord-024076-q9fw7ch1 24 4 model model NN cord-024076-q9fw7ch1 24 5 with with IN cord-024076-q9fw7ch1 24 6 acid acid NN cord-024076-q9fw7ch1 24 7 lung lung NN cord-024076-q9fw7ch1 24 8 injury injury NN cord-024076-q9fw7ch1 24 9 , , , cord-024076-q9fw7ch1 24 10 ACE ace NN cord-024076-q9fw7ch1 24 11 2 2 CD cord-024076-q9fw7ch1 24 12 downregulation downregulation NN cord-024076-q9fw7ch1 24 13 induced induce VBN cord-024076-q9fw7ch1 24 14 by by IN cord-024076-q9fw7ch1 24 15 SARS SARS NNP cord-024076-q9fw7ch1 24 16 - - HYPH cord-024076-q9fw7ch1 24 17 CoV CoV NNP cord-024076-q9fw7ch1 24 18 , , , cord-024076-q9fw7ch1 24 19 the the DT cord-024076-q9fw7ch1 24 20 virus virus NN cord-024076-q9fw7ch1 24 21 responsible responsible JJ cord-024076-q9fw7ch1 24 22 for for IN cord-024076-q9fw7ch1 24 23 the the DT cord-024076-q9fw7ch1 24 24 SARS SARS NNP cord-024076-q9fw7ch1 24 25 virus virus NN cord-024076-q9fw7ch1 24 26 outbreak outbreak NN cord-024076-q9fw7ch1 24 27 in in IN cord-024076-q9fw7ch1 24 28 2003 2003 CD cord-024076-q9fw7ch1 24 29 , , , cord-024076-q9fw7ch1 24 30 worsened worsen VBD cord-024076-q9fw7ch1 24 31 lung lung NN cord-024076-q9fw7ch1 24 32 injury injury NN cord-024076-q9fw7ch1 24 33 , , , cord-024076-q9fw7ch1 24 34 but but CC cord-024076-q9fw7ch1 24 35 this this DT cord-024076-q9fw7ch1 24 36 lung lung NN cord-024076-q9fw7ch1 24 37 injury injury NN cord-024076-q9fw7ch1 24 38 was be VBD cord-024076-q9fw7ch1 24 39 improved improve VBN cord-024076-q9fw7ch1 24 40 by by IN cord-024076-q9fw7ch1 24 41 therapy therapy NN cord-024076-q9fw7ch1 24 42 with with IN cord-024076-q9fw7ch1 24 43 an an DT cord-024076-q9fw7ch1 24 44 ARB.(9 arb.(9 NN cord-024076-q9fw7ch1 24 45 ) ) -RRB- cord-024076-q9fw7ch1 25 1 These these DT cord-024076-q9fw7ch1 25 2 findings finding NNS cord-024076-q9fw7ch1 25 3 suggest suggest VBP cord-024076-q9fw7ch1 25 4 that that IN cord-024076-q9fw7ch1 25 5 SARS SARS NNP cord-024076-q9fw7ch1 25 6 - - HYPH cord-024076-q9fw7ch1 25 7 CoV CoV NNP cord-024076-q9fw7ch1 25 8 may may MD cord-024076-q9fw7ch1 25 9 induce induce VB cord-024076-q9fw7ch1 25 10 lung lung NN cord-024076-q9fw7ch1 25 11 injury injury NN cord-024076-q9fw7ch1 25 12 , , , cord-024076-q9fw7ch1 25 13 but but CC cord-024076-q9fw7ch1 25 14 the the DT cord-024076-q9fw7ch1 25 15 injury injury NN cord-024076-q9fw7ch1 25 16 can can MD cord-024076-q9fw7ch1 25 17 be be VB cord-024076-q9fw7ch1 25 18 ameliorated ameliorate VBN cord-024076-q9fw7ch1 25 19 by by IN cord-024076-q9fw7ch1 25 20 ARB ARB NNP cord-024076-q9fw7ch1 25 21 administration.(9 administration.(9 NNP cord-024076-q9fw7ch1 25 22 ) ) -RRB- cord-024076-q9fw7ch1 26 1 These these DT cord-024076-q9fw7ch1 26 2 preclinical preclinical JJ cord-024076-q9fw7ch1 26 3 findings finding NNS cord-024076-q9fw7ch1 26 4 suggest suggest VBP cord-024076-q9fw7ch1 26 5 a a DT cord-024076-q9fw7ch1 26 6 possible possible JJ cord-024076-q9fw7ch1 26 7 protective protective JJ cord-024076-q9fw7ch1 26 8 role role NN cord-024076-q9fw7ch1 26 9 of of IN cord-024076-q9fw7ch1 26 10 ARB ARB NNP cord-024076-q9fw7ch1 26 11 in in IN cord-024076-q9fw7ch1 26 12 SARS SARS NNP cord-024076-q9fw7ch1 26 13 - - HYPH cord-024076-q9fw7ch1 26 14 CoVassociated CoVassociated NNP cord-024076-q9fw7ch1 26 15 lung lung NN cord-024076-q9fw7ch1 26 16 injury injury NN cord-024076-q9fw7ch1 26 17 and and CC cord-024076-q9fw7ch1 26 18 lend lend VB cord-024076-q9fw7ch1 26 19 credence credence NN cord-024076-q9fw7ch1 26 20 to to IN cord-024076-q9fw7ch1 26 21 the the DT cord-024076-q9fw7ch1 26 22 hypothesis hypothesis NN cord-024076-q9fw7ch1 26 23 that that IN cord-024076-q9fw7ch1 26 24 primary primary JJ cord-024076-q9fw7ch1 26 25 activation activation NN cord-024076-q9fw7ch1 26 26 of of IN cord-024076-q9fw7ch1 26 27 the the DT cord-024076-q9fw7ch1 26 28 RAAS raa NNS cord-024076-q9fw7ch1 26 29 in in IN cord-024076-q9fw7ch1 26 30 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 26 31 patients patient NNS cord-024076-q9fw7ch1 26 32 , , , cord-024076-q9fw7ch1 26 33 rather rather RB cord-024076-q9fw7ch1 26 34 than than IN cord-024076-q9fw7ch1 26 35 its -PRON- PRP$ cord-024076-q9fw7ch1 26 36 inhibition inhibition NN cord-024076-q9fw7ch1 26 37 , , , cord-024076-q9fw7ch1 26 38 renders render VBZ cord-024076-q9fw7ch1 26 39 them -PRON- PRP cord-024076-q9fw7ch1 26 40 more more RBR cord-024076-q9fw7ch1 26 41 prone prone JJ cord-024076-q9fw7ch1 26 42 to to IN cord-024076-q9fw7ch1 26 43 a a DT cord-024076-q9fw7ch1 26 44 deleterious deleterious JJ cord-024076-q9fw7ch1 26 45 outcome outcome NN cord-024076-q9fw7ch1 26 46 . . . cord-024076-q9fw7ch1 27 1 However however RB cord-024076-q9fw7ch1 27 2 , , , cord-024076-q9fw7ch1 27 3 currently currently RB cord-024076-q9fw7ch1 27 4 there there EX cord-024076-q9fw7ch1 27 5 is be VBZ cord-024076-q9fw7ch1 27 6 no no DT cord-024076-q9fw7ch1 27 7 clinical clinical JJ cord-024076-q9fw7ch1 27 8 evidence evidence NN cord-024076-q9fw7ch1 27 9 that that WDT cord-024076-q9fw7ch1 27 10 has have VBZ cord-024076-q9fw7ch1 27 11 proven prove VBN cord-024076-q9fw7ch1 27 12 that that IN cord-024076-q9fw7ch1 27 13 ACE ACE NNP cord-024076-q9fw7ch1 27 14 inhibitors inhibitor NNS cord-024076-q9fw7ch1 27 15 or or CC cord-024076-q9fw7ch1 27 16 ARB arb NN cord-024076-q9fw7ch1 27 17 - - HYPH cord-024076-q9fw7ch1 27 18 induced induce VBN cord-024076-q9fw7ch1 27 19 ACE ace NN cord-024076-q9fw7ch1 27 20 2 2 CD cord-024076-q9fw7ch1 27 21 activity activity NN cord-024076-q9fw7ch1 27 22 is be VBZ cord-024076-q9fw7ch1 27 23 an an DT cord-024076-q9fw7ch1 27 24 effective effective JJ cord-024076-q9fw7ch1 27 25 therapy therapy NN cord-024076-q9fw7ch1 27 26 for for IN cord-024076-q9fw7ch1 27 27 COVID-19-induced COVID-19-induced NNP cord-024076-q9fw7ch1 27 28 lung lung NN cord-024076-q9fw7ch1 27 29 injury injury NN cord-024076-q9fw7ch1 27 30 . . . cord-024076-q9fw7ch1 28 1 In in IN cord-024076-q9fw7ch1 28 2 addition addition NN cord-024076-q9fw7ch1 28 3 , , , cord-024076-q9fw7ch1 28 4 ACE ace NN cord-024076-q9fw7ch1 28 5 2 2 CD cord-024076-q9fw7ch1 28 6 activity activity NN cord-024076-q9fw7ch1 28 7 may may MD cord-024076-q9fw7ch1 28 8 not not RB cord-024076-q9fw7ch1 28 9 correlate correlate VB cord-024076-q9fw7ch1 28 10 with with IN cord-024076-q9fw7ch1 28 11 the the DT cord-024076-q9fw7ch1 28 12 degree degree NN cord-024076-q9fw7ch1 28 13 of of IN cord-024076-q9fw7ch1 28 14 severity severity NN cord-024076-q9fw7ch1 28 15 of of IN cord-024076-q9fw7ch1 28 16 infection infection NN cord-024076-q9fw7ch1 28 17 with with IN cord-024076-q9fw7ch1 28 18 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 28 19 infection infection NN cord-024076-q9fw7ch1 28 20 . . . cord-024076-q9fw7ch1 29 1 Although although IN cord-024076-q9fw7ch1 29 2 ACE ace NN cord-024076-q9fw7ch1 29 3 2 2 CD cord-024076-q9fw7ch1 29 4 is be VBZ cord-024076-q9fw7ch1 29 5 presumed presume VBN cord-024076-q9fw7ch1 29 6 to to TO cord-024076-q9fw7ch1 29 7 be be VB cord-024076-q9fw7ch1 29 8 an an DT cord-024076-q9fw7ch1 29 9 important important JJ cord-024076-q9fw7ch1 29 10 mediator mediator NN cord-024076-q9fw7ch1 29 11 for for IN cord-024076-q9fw7ch1 29 12 SARS SARS NNP cord-024076-q9fw7ch1 29 13 - - HYPH cord-024076-q9fw7ch1 29 14 CoV CoV NNP cord-024076-q9fw7ch1 29 15 infection infection NN cord-024076-q9fw7ch1 29 16 , , , cord-024076-q9fw7ch1 29 17 the the DT cord-024076-q9fw7ch1 29 18 absence absence NN cord-024076-q9fw7ch1 29 19 of of IN cord-024076-q9fw7ch1 29 20 SARS SARS NNP cord-024076-q9fw7ch1 29 21 - - HYPH cord-024076-q9fw7ch1 29 22 CoV CoV NNP cord-024076-q9fw7ch1 29 23 has have VBZ cord-024076-q9fw7ch1 29 24 been be VBN cord-024076-q9fw7ch1 29 25 found find VBN cord-024076-q9fw7ch1 29 26 in in IN cord-024076-q9fw7ch1 29 27 some some DT cord-024076-q9fw7ch1 29 28 cell cell NN cord-024076-q9fw7ch1 29 29 types type NNS cord-024076-q9fw7ch1 29 30 expressing express VBG cord-024076-q9fw7ch1 29 31 ACE ace NN cord-024076-q9fw7ch1 29 32 2.(10 2.(10 CD cord-024076-q9fw7ch1 29 33 ) ) -RRB- cord-024076-q9fw7ch1 30 1 On on IN cord-024076-q9fw7ch1 30 2 the the DT cord-024076-q9fw7ch1 30 3 other other JJ cord-024076-q9fw7ch1 30 4 hand hand NN cord-024076-q9fw7ch1 30 5 , , , cord-024076-q9fw7ch1 30 6 infection infection NN cord-024076-q9fw7ch1 30 7 was be VBD cord-024076-q9fw7ch1 30 8 present present JJ cord-024076-q9fw7ch1 30 9 in in IN cord-024076-q9fw7ch1 30 10 cells cell NNS cord-024076-q9fw7ch1 30 11 apparently apparently RB cord-024076-q9fw7ch1 30 12 lacking lack VBG cord-024076-q9fw7ch1 30 13 ACE ace NN cord-024076-q9fw7ch1 30 14 2 2 CD cord-024076-q9fw7ch1 30 15 , , , cord-024076-q9fw7ch1 30 16 suggesting suggest VBG cord-024076-q9fw7ch1 30 17 that that IN cord-024076-q9fw7ch1 30 18 additional additional JJ cord-024076-q9fw7ch1 30 19 co co NNS cord-024076-q9fw7ch1 30 20 - - NNS cord-024076-q9fw7ch1 30 21 factors factor NNS cord-024076-q9fw7ch1 30 22 may may MD cord-024076-q9fw7ch1 30 23 be be VB cord-024076-q9fw7ch1 30 24 needed need VBN cord-024076-q9fw7ch1 30 25 for for IN cord-024076-q9fw7ch1 30 26 adequate adequate JJ cord-024076-q9fw7ch1 30 27 cellular cellular JJ cord-024076-q9fw7ch1 30 28 infection infection NN cord-024076-q9fw7ch1 30 29 . . . cord-024076-q9fw7ch1 31 1 ( ( -LRB- cord-024076-q9fw7ch1 31 2 10 10 CD cord-024076-q9fw7ch1 31 3 ) ) -RRB- cord-024076-q9fw7ch1 32 1 Because because IN cord-024076-q9fw7ch1 32 2 of of IN cord-024076-q9fw7ch1 32 3 the the DT cord-024076-q9fw7ch1 32 4 connection connection NN cord-024076-q9fw7ch1 32 5 of of IN cord-024076-q9fw7ch1 32 6 the the DT cord-024076-q9fw7ch1 32 7 ACE ace NN cord-024076-q9fw7ch1 32 8 2 2 CD cord-024076-q9fw7ch1 32 9 pathway pathway NN cord-024076-q9fw7ch1 32 10 with with IN cord-024076-q9fw7ch1 32 11 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 32 12 infection infection NN cord-024076-q9fw7ch1 32 13 , , , cord-024076-q9fw7ch1 32 14 there there EX cord-024076-q9fw7ch1 32 15 has have VBZ cord-024076-q9fw7ch1 32 16 been be VBN cord-024076-q9fw7ch1 32 17 widespread widespread JJ cord-024076-q9fw7ch1 32 18 concern concern NN cord-024076-q9fw7ch1 32 19 amongst amongst IN cord-024076-q9fw7ch1 32 20 physicians physician NNS cord-024076-q9fw7ch1 32 21 and and CC cord-024076-q9fw7ch1 32 22 patients patient NNS cord-024076-q9fw7ch1 32 23 , , , cord-024076-q9fw7ch1 32 24 whether whether IN cord-024076-q9fw7ch1 32 25 RAAS RAAS NNP cord-024076-q9fw7ch1 32 26 antagonists antagonist NNS cord-024076-q9fw7ch1 32 27 such such JJ cord-024076-q9fw7ch1 32 28 as as IN cord-024076-q9fw7ch1 32 29 ACE ace NN cord-024076-q9fw7ch1 32 30 inhibitors inhibitor NNS cord-024076-q9fw7ch1 32 31 and and CC cord-024076-q9fw7ch1 32 32 ARBs arb NNS cord-024076-q9fw7ch1 32 33 confer confer VBP cord-024076-q9fw7ch1 32 34 an an DT cord-024076-q9fw7ch1 32 35 increased increase VBN cord-024076-q9fw7ch1 32 36 risk risk NN cord-024076-q9fw7ch1 32 37 of of IN cord-024076-q9fw7ch1 32 38 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 32 39 infection infection NN cord-024076-q9fw7ch1 32 40 . . . cord-024076-q9fw7ch1 33 1 Many many JJ cord-024076-q9fw7ch1 33 2 patients patient NNS cord-024076-q9fw7ch1 33 3 and and CC cord-024076-q9fw7ch1 33 4 their -PRON- PRP$ cord-024076-q9fw7ch1 33 5 physicians physician NNS cord-024076-q9fw7ch1 33 6 , , , cord-024076-q9fw7ch1 33 7 including include VBG cord-024076-q9fw7ch1 33 8 those those DT cord-024076-q9fw7ch1 33 9 in in IN cord-024076-q9fw7ch1 33 10 South South NNP cord-024076-q9fw7ch1 33 11 Africa Africa NNP cord-024076-q9fw7ch1 33 12 , , , cord-024076-q9fw7ch1 33 13 have have VBP cord-024076-q9fw7ch1 33 14 contemplated contemplate VBN cord-024076-q9fw7ch1 33 15 a a DT cord-024076-q9fw7ch1 33 16 cessation cessation NN cord-024076-q9fw7ch1 33 17 of of IN cord-024076-q9fw7ch1 33 18 ACE ACE NNP cord-024076-q9fw7ch1 33 19 inhibitors inhibitor NNS cord-024076-q9fw7ch1 33 20 or or CC cord-024076-q9fw7ch1 33 21 ARB ARB NNP cord-024076-q9fw7ch1 33 22 medications medication NNS cord-024076-q9fw7ch1 33 23 . . . cord-024076-q9fw7ch1 34 1 In in IN cord-024076-q9fw7ch1 34 2 the the DT cord-024076-q9fw7ch1 34 3 Wuhan Wuhan NNP cord-024076-q9fw7ch1 34 4 study study NN cord-024076-q9fw7ch1 34 5 , , , cord-024076-q9fw7ch1 34 6 ( ( -LRB- cord-024076-q9fw7ch1 34 7 2 2 LS cord-024076-q9fw7ch1 34 8 ) ) -RRB- cord-024076-q9fw7ch1 34 9 there there EX cord-024076-q9fw7ch1 34 10 was be VBD cord-024076-q9fw7ch1 34 11 no no DT cord-024076-q9fw7ch1 34 12 information information NN cord-024076-q9fw7ch1 34 13 of of IN cord-024076-q9fw7ch1 34 14 how how WRB cord-024076-q9fw7ch1 34 15 many many JJ cord-024076-q9fw7ch1 34 16 of of IN cord-024076-q9fw7ch1 34 17 the the DT cord-024076-q9fw7ch1 34 18 patients patient NNS cord-024076-q9fw7ch1 34 19 with with IN cord-024076-q9fw7ch1 34 20 severe severe JJ cord-024076-q9fw7ch1 34 21 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 34 22 infection infection NN cord-024076-q9fw7ch1 34 23 were be VBD cord-024076-q9fw7ch1 34 24 on on IN cord-024076-q9fw7ch1 34 25 ACE ACE NNP cord-024076-q9fw7ch1 34 26 inhibitors inhibitor NNS cord-024076-q9fw7ch1 34 27 or or CC cord-024076-q9fw7ch1 34 28 ARBs arb NNS cord-024076-q9fw7ch1 34 29 . . . cord-024076-q9fw7ch1 35 1 Furthermore furthermore RB cord-024076-q9fw7ch1 35 2 , , , cord-024076-q9fw7ch1 35 3 there there EX cord-024076-q9fw7ch1 35 4 are be VBP cord-024076-q9fw7ch1 35 5 no no DT cord-024076-q9fw7ch1 35 6 published publish VBN cord-024076-q9fw7ch1 35 7 studies study NNS cord-024076-q9fw7ch1 35 8 to to IN cord-024076-q9fw7ch1 35 9 date date NN cord-024076-q9fw7ch1 35 10 showing show VBG cord-024076-q9fw7ch1 35 11 that that IN cord-024076-q9fw7ch1 35 12 diabetes diabetes NN cord-024076-q9fw7ch1 35 13 and and CC cord-024076-q9fw7ch1 35 14 hypertension hypertension NN cord-024076-q9fw7ch1 35 15 are be VBP cord-024076-q9fw7ch1 35 16 independent independent JJ cord-024076-q9fw7ch1 35 17 predictors predictor NNS cord-024076-q9fw7ch1 35 18 of of IN cord-024076-q9fw7ch1 35 19 mortality mortality NN cord-024076-q9fw7ch1 35 20 with with IN cord-024076-q9fw7ch1 35 21 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 35 22 infection infection NN cord-024076-q9fw7ch1 35 23 . . . cord-024076-q9fw7ch1 36 1 Thus thus RB cord-024076-q9fw7ch1 36 2 , , , cord-024076-q9fw7ch1 36 3 a a DT cord-024076-q9fw7ch1 36 4 clear clear JJ cord-024076-q9fw7ch1 36 5 causal causal JJ cord-024076-q9fw7ch1 36 6 relationship relationship NN cord-024076-q9fw7ch1 36 7 between between IN cord-024076-q9fw7ch1 36 8 those those DT cord-024076-q9fw7ch1 36 9 with with IN cord-024076-q9fw7ch1 36 10 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 36 11 disease disease NN cord-024076-q9fw7ch1 36 12 , , , cord-024076-q9fw7ch1 36 13 hypertension hypertension NN cord-024076-q9fw7ch1 36 14 , , , cord-024076-q9fw7ch1 36 15 heart heart NN cord-024076-q9fw7ch1 36 16 failure failure NN cord-024076-q9fw7ch1 36 17 with with IN cord-024076-q9fw7ch1 36 18 reduced reduce VBN cord-024076-q9fw7ch1 36 19 ejection ejection NN cord-024076-q9fw7ch1 36 20 fraction fraction NN cord-024076-q9fw7ch1 36 21 ( ( -LRB- cord-024076-q9fw7ch1 36 22 HFrEF HFrEF NNP cord-024076-q9fw7ch1 36 23 ) ) -RRB- cord-024076-q9fw7ch1 36 24 , , , cord-024076-q9fw7ch1 36 25 and and CC cord-024076-q9fw7ch1 36 26 diabetes diabetes NN cord-024076-q9fw7ch1 36 27 with with IN cord-024076-q9fw7ch1 36 28 chronic chronic JJ cord-024076-q9fw7ch1 36 29 kidney kidney NN cord-024076-q9fw7ch1 36 30 disease disease NN cord-024076-q9fw7ch1 36 31 ( ( -LRB- cord-024076-q9fw7ch1 36 32 DCKD DCKD NNP cord-024076-q9fw7ch1 36 33 ) ) -RRB- cord-024076-q9fw7ch1 36 34 on on IN cord-024076-q9fw7ch1 36 35 ACE ACE NNP cord-024076-q9fw7ch1 36 36 inhibitors inhibitor NNS cord-024076-q9fw7ch1 36 37 or or CC cord-024076-q9fw7ch1 36 38 ARB ARB NNP cord-024076-q9fw7ch1 36 39 treatment treatment NN cord-024076-q9fw7ch1 36 40 and and CC cord-024076-q9fw7ch1 36 41 an an DT cord-024076-q9fw7ch1 36 42 increased increase VBN cord-024076-q9fw7ch1 36 43 risk risk NN cord-024076-q9fw7ch1 36 44 of of IN cord-024076-q9fw7ch1 36 45 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 36 46 does do VBZ cord-024076-q9fw7ch1 36 47 not not RB cord-024076-q9fw7ch1 36 48 exist exist VB cord-024076-q9fw7ch1 36 49 . . . cord-024076-q9fw7ch1 37 1 There there EX cord-024076-q9fw7ch1 37 2 are be VBP cord-024076-q9fw7ch1 37 3 alternative alternative JJ cord-024076-q9fw7ch1 37 4 agents agent NNS cord-024076-q9fw7ch1 37 5 that that WDT cord-024076-q9fw7ch1 37 6 can can MD cord-024076-q9fw7ch1 37 7 be be VB cord-024076-q9fw7ch1 37 8 used use VBN cord-024076-q9fw7ch1 37 9 for for IN cord-024076-q9fw7ch1 37 10 the the DT cord-024076-q9fw7ch1 37 11 management management NN cord-024076-q9fw7ch1 37 12 of of IN cord-024076-q9fw7ch1 37 13 hypertension hypertension NN cord-024076-q9fw7ch1 37 14 , , , cord-024076-q9fw7ch1 37 15 but but CC cord-024076-q9fw7ch1 37 16 DCKD DCKD NNP cord-024076-q9fw7ch1 37 17 and and CC cord-024076-q9fw7ch1 37 18 HFrEF HFrEF NNP cord-024076-q9fw7ch1 37 19 are be VBP cord-024076-q9fw7ch1 37 20 compelling compelling JJ cord-024076-q9fw7ch1 37 21 indications indication NNS cord-024076-q9fw7ch1 37 22 for for IN cord-024076-q9fw7ch1 37 23 these these DT cord-024076-q9fw7ch1 37 24 drugs drug NNS cord-024076-q9fw7ch1 37 25 . . . cord-024076-q9fw7ch1 38 1 Patients patient NNS cord-024076-q9fw7ch1 38 2 , , , cord-024076-q9fw7ch1 38 3 influenced influence VBN cord-024076-q9fw7ch1 38 4 by by IN cord-024076-q9fw7ch1 38 5 the the DT cord-024076-q9fw7ch1 38 6 media medium NNS cord-024076-q9fw7ch1 38 7 , , , cord-024076-q9fw7ch1 38 8 may may MD cord-024076-q9fw7ch1 38 9 request request VB cord-024076-q9fw7ch1 38 10 an an DT cord-024076-q9fw7ch1 38 11 alternative alternative JJ cord-024076-q9fw7ch1 38 12 anti anti JJ cord-024076-q9fw7ch1 38 13 - - JJ cord-024076-q9fw7ch1 38 14 hypertensive hypertensive JJ cord-024076-q9fw7ch1 38 15 agent agent NN cord-024076-q9fw7ch1 38 16 , , , cord-024076-q9fw7ch1 38 17 and and CC cord-024076-q9fw7ch1 38 18 that that DT cord-024076-q9fw7ch1 38 19 may may MD cord-024076-q9fw7ch1 38 20 be be VB cord-024076-q9fw7ch1 38 21 appropriate appropriate JJ cord-024076-q9fw7ch1 38 22 for for IN cord-024076-q9fw7ch1 38 23 them -PRON- PRP cord-024076-q9fw7ch1 38 24 , , , cord-024076-q9fw7ch1 38 25 but but CC cord-024076-q9fw7ch1 38 26 it -PRON- PRP cord-024076-q9fw7ch1 38 27 is be VBZ cord-024076-q9fw7ch1 38 28 inappropriate inappropriate JJ cord-024076-q9fw7ch1 38 29 to to TO cord-024076-q9fw7ch1 38 30 recommend recommend VB cord-024076-q9fw7ch1 38 31 discontinuation discontinuation NN cord-024076-q9fw7ch1 38 32 of of IN cord-024076-q9fw7ch1 38 33 ACE ace NN cord-024076-q9fw7ch1 38 34 inhibitors inhibitor NNS cord-024076-q9fw7ch1 38 35 or or CC cord-024076-q9fw7ch1 38 36 ARB arb NN cord-024076-q9fw7ch1 38 37 treatment treatment NN cord-024076-q9fw7ch1 38 38 in in IN cord-024076-q9fw7ch1 38 39 patients patient NNS cord-024076-q9fw7ch1 38 40 with with IN cord-024076-q9fw7ch1 38 41 HFrEF HFrEF NNP cord-024076-q9fw7ch1 38 42 and and CC cord-024076-q9fw7ch1 38 43 DCKD DCKD NNP cord-024076-q9fw7ch1 38 44 based base VBN cord-024076-q9fw7ch1 38 45 on on IN cord-024076-q9fw7ch1 38 46 a a DT cord-024076-q9fw7ch1 38 47 hypothetical hypothetical JJ cord-024076-q9fw7ch1 38 48 adverse adverse JJ cord-024076-q9fw7ch1 38 49 outcome outcome NN cord-024076-q9fw7ch1 38 50 with with IN cord-024076-q9fw7ch1 38 51 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 38 52 infection infection NN cord-024076-q9fw7ch1 38 53 . . . cord-024076-q9fw7ch1 39 1 Importantly importantly RB cord-024076-q9fw7ch1 39 2 , , , cord-024076-q9fw7ch1 39 3 the the DT cord-024076-q9fw7ch1 39 4 indication indication NN cord-024076-q9fw7ch1 39 5 for for IN cord-024076-q9fw7ch1 39 6 which which WDT cord-024076-q9fw7ch1 39 7 the the DT cord-024076-q9fw7ch1 39 8 drugs drug NNS cord-024076-q9fw7ch1 39 9 were be VBD cord-024076-q9fw7ch1 39 10 originally originally RB cord-024076-q9fw7ch1 39 11 prescribed prescribe VBN cord-024076-q9fw7ch1 39 12 may may MD cord-024076-q9fw7ch1 39 13 have have VB cord-024076-q9fw7ch1 39 14 changed change VBN cord-024076-q9fw7ch1 39 15 since since IN cord-024076-q9fw7ch1 39 16 the the DT cord-024076-q9fw7ch1 39 17 drugs drug NNS cord-024076-q9fw7ch1 39 18 were be VBD cord-024076-q9fw7ch1 39 19 initiated initiate VBN cord-024076-q9fw7ch1 39 20 , , , cord-024076-q9fw7ch1 39 21 and and CC cord-024076-q9fw7ch1 39 22 a a DT cord-024076-q9fw7ch1 39 23 patient patient NN cord-024076-q9fw7ch1 39 24 with with IN cord-024076-q9fw7ch1 39 25 hypertension hypertension NN cord-024076-q9fw7ch1 39 26 may may MD cord-024076-q9fw7ch1 39 27 not not RB cord-024076-q9fw7ch1 39 28 be be VB cord-024076-q9fw7ch1 39 29 aware aware JJ cord-024076-q9fw7ch1 39 30 of of IN cord-024076-q9fw7ch1 39 31 that that DT cord-024076-q9fw7ch1 39 32 they -PRON- PRP cord-024076-q9fw7ch1 39 33 have have VBP cord-024076-q9fw7ch1 39 34 developed develop VBN cord-024076-q9fw7ch1 39 35 LV LV NNP cord-024076-q9fw7ch1 39 36 systolic systolic JJ cord-024076-q9fw7ch1 39 37 dysfunction dysfunction NN cord-024076-q9fw7ch1 39 38 or or CC cord-024076-q9fw7ch1 39 39 that that IN cord-024076-q9fw7ch1 39 40 a a DT cord-024076-q9fw7ch1 39 41 diabetic diabetic NN cord-024076-q9fw7ch1 39 42 has have VBZ cord-024076-q9fw7ch1 39 43 developed develop VBN cord-024076-q9fw7ch1 39 44 proteinuria proteinuria NN cord-024076-q9fw7ch1 39 45 . . . cord-024076-q9fw7ch1 40 1 A a DT cord-024076-q9fw7ch1 40 2 recent recent JJ cord-024076-q9fw7ch1 40 3 report report NN cord-024076-q9fw7ch1 40 4 suggested suggest VBD cord-024076-q9fw7ch1 40 5 a a DT cord-024076-q9fw7ch1 40 6 reverse reverse JJ cord-024076-q9fw7ch1 40 7 causality causality NN cord-024076-q9fw7ch1 40 8 relationship relationship NN cord-024076-q9fw7ch1 40 9 by by IN cord-024076-q9fw7ch1 40 10 the the DT cord-024076-q9fw7ch1 40 11 fact fact NN cord-024076-q9fw7ch1 40 12 that that IN cord-024076-q9fw7ch1 40 13 patients patient NNS cord-024076-q9fw7ch1 40 14 who who WP cord-024076-q9fw7ch1 40 15 are be VBP cord-024076-q9fw7ch1 40 16 receiving receive VBG cord-024076-q9fw7ch1 40 17 ACE ACE NNP cord-024076-q9fw7ch1 40 18 inhibitors inhibitor NNS cord-024076-q9fw7ch1 40 19 or or CC cord-024076-q9fw7ch1 40 20 ARB ARB NNP cord-024076-q9fw7ch1 40 21 may may MD cord-024076-q9fw7ch1 40 22 be be VB cord-024076-q9fw7ch1 40 23 more more RBR cord-024076-q9fw7ch1 40 24 susceptible susceptible JJ cord-024076-q9fw7ch1 40 25 to to IN cord-024076-q9fw7ch1 40 26 viral viral JJ cord-024076-q9fw7ch1 40 27 infections infection NNS cord-024076-q9fw7ch1 40 28 and and CC cord-024076-q9fw7ch1 40 29 more more RBR cord-024076-q9fw7ch1 40 30 likely likely JJ cord-024076-q9fw7ch1 40 31 to to TO cord-024076-q9fw7ch1 40 32 have have VB cord-024076-q9fw7ch1 40 33 a a DT cord-024076-q9fw7ch1 40 34 higher high JJR cord-024076-q9fw7ch1 40 35 risk risk NN cord-024076-q9fw7ch1 40 36 of of IN cord-024076-q9fw7ch1 40 37 dying die VBG cord-024076-q9fw7ch1 40 38 because because IN cord-024076-q9fw7ch1 40 39 they -PRON- PRP cord-024076-q9fw7ch1 40 40 are be VBP cord-024076-q9fw7ch1 40 41 older old JJR cord-024076-q9fw7ch1 40 42 and and CC cord-024076-q9fw7ch1 40 43 hence hence RB cord-024076-q9fw7ch1 40 44 would would MD cord-024076-q9fw7ch1 40 45 have have VB cord-024076-q9fw7ch1 40 46 a a DT cord-024076-q9fw7ch1 40 47 higher high JJR cord-024076-q9fw7ch1 40 48 prevalence prevalence NN cord-024076-q9fw7ch1 40 49 of of IN cord-024076-q9fw7ch1 40 50 hypertension hypertension NN cord-024076-q9fw7ch1 40 51 , , , cord-024076-q9fw7ch1 40 52 renal renal JJ cord-024076-q9fw7ch1 40 53 disease disease NN cord-024076-q9fw7ch1 40 54 and and CC cord-024076-q9fw7ch1 40 55 diabetes diabetes NN cord-024076-q9fw7ch1 40 56 . . . cord-024076-q9fw7ch1 41 1 ( ( -LRB- cord-024076-q9fw7ch1 41 2 11 11 CD cord-024076-q9fw7ch1 41 3 ) ) -RRB- cord-024076-q9fw7ch1 42 1 It -PRON- PRP cord-024076-q9fw7ch1 42 2 is be VBZ cord-024076-q9fw7ch1 42 3 important important JJ cord-024076-q9fw7ch1 42 4 to to TO cord-024076-q9fw7ch1 42 5 recognize recognize VB cord-024076-q9fw7ch1 42 6 that that IN cord-024076-q9fw7ch1 42 7 pathophysiological pathophysiological JJ cord-024076-q9fw7ch1 42 8 mechanisms mechanism NNS cord-024076-q9fw7ch1 42 9 that that WDT cord-024076-q9fw7ch1 42 10 lead lead VBP cord-024076-q9fw7ch1 42 11 to to IN cord-024076-q9fw7ch1 42 12 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 42 13 disease disease NN cord-024076-q9fw7ch1 42 14 are be VBP cord-024076-q9fw7ch1 42 15 known know VBN cord-024076-q9fw7ch1 42 16 to to TO cord-024076-q9fw7ch1 42 17 overlap overlap VB cord-024076-q9fw7ch1 42 18 with with IN cord-024076-q9fw7ch1 42 19 pathways pathway NNS cord-024076-q9fw7ch1 42 20 that that WDT cord-024076-q9fw7ch1 42 21 regulate regulate VBP cord-024076-q9fw7ch1 42 22 immunological immunological JJ cord-024076-q9fw7ch1 42 23 functions function NNS cord-024076-q9fw7ch1 42 24 . . . cord-024076-q9fw7ch1 43 1 Thus thus RB cord-024076-q9fw7ch1 43 2 , , , cord-024076-q9fw7ch1 43 3 age age NN cord-024076-q9fw7ch1 43 4 is be VBZ cord-024076-q9fw7ch1 43 5 one one CD cord-024076-q9fw7ch1 43 6 of of IN cord-024076-q9fw7ch1 43 7 the the DT cord-024076-q9fw7ch1 43 8 strongest strong JJS cord-024076-q9fw7ch1 43 9 risk risk NN cord-024076-q9fw7ch1 43 10 predictors predictor NNS cord-024076-q9fw7ch1 43 11 for for IN cord-024076-q9fw7ch1 43 12 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 43 13 disease disease NN cord-024076-q9fw7ch1 43 14 and and CC cord-024076-q9fw7ch1 43 15 the the DT cord-024076-q9fw7ch1 43 16 effect effect NN cord-024076-q9fw7ch1 43 17 of of IN cord-024076-q9fw7ch1 43 18 ageing age VBG cord-024076-q9fw7ch1 43 19 on on IN cord-024076-q9fw7ch1 43 20 immune immune JJ cord-024076-q9fw7ch1 43 21 function function NN cord-024076-q9fw7ch1 43 22 may may MD cord-024076-q9fw7ch1 43 23 be be VB cord-024076-q9fw7ch1 43 24 equally equally RB cord-024076-q9fw7ch1 43 25 important important JJ cord-024076-q9fw7ch1 43 26 for for IN cord-024076-q9fw7ch1 43 27 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 43 28 susceptibility susceptibility NN cord-024076-q9fw7ch1 43 29 and and CC cord-024076-q9fw7ch1 43 30 severity severity NN cord-024076-q9fw7ch1 43 31 . . . cord-024076-q9fw7ch1 44 1 ( ( -LRB- cord-024076-q9fw7ch1 44 2 12 12 CD cord-024076-q9fw7ch1 44 3 ) ) -RRB- cord-024076-q9fw7ch1 45 1 A a DT cord-024076-q9fw7ch1 45 2 dysregulated dysregulated JJ cord-024076-q9fw7ch1 45 3 immunologic immunologic JJ cord-024076-q9fw7ch1 45 4 state state NN cord-024076-q9fw7ch1 45 5 corresponds correspond VBZ cord-024076-q9fw7ch1 45 6 with with IN cord-024076-q9fw7ch1 45 7 an an DT cord-024076-q9fw7ch1 45 8 elevated elevated JJ cord-024076-q9fw7ch1 45 9 risk risk NN cord-024076-q9fw7ch1 45 10 of of IN cord-024076-q9fw7ch1 45 11 incident incident NN cord-024076-q9fw7ch1 45 12 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 45 13 disease disease NN cord-024076-q9fw7ch1 45 14 and and CC cord-024076-q9fw7ch1 45 15 thus thus RB cord-024076-q9fw7ch1 45 16 other other JJ cord-024076-q9fw7ch1 45 17 traditional traditional JJ cord-024076-q9fw7ch1 45 18 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 45 19 disease disease NN cord-024076-q9fw7ch1 45 20 risk risk NN cord-024076-q9fw7ch1 45 21 factors factor NNS cord-024076-q9fw7ch1 45 22 such such JJ cord-024076-q9fw7ch1 45 23 as as IN cord-024076-q9fw7ch1 45 24 diabetes diabetes NN cord-024076-q9fw7ch1 45 25 and and CC cord-024076-q9fw7ch1 45 26 hyperlipidaemia hyperlipidaemia NN cord-024076-q9fw7ch1 45 27 impact impact NN cord-024076-q9fw7ch1 45 28 immune immune JJ cord-024076-q9fw7ch1 45 29 function function NN cord-024076-q9fw7ch1 45 30 . . . cord-024076-q9fw7ch1 46 1 ( ( -LRB- cord-024076-q9fw7ch1 46 2 13 13 CD cord-024076-q9fw7ch1 46 3 ) ) -RRB- cord-024076-q9fw7ch1 47 1 Thus thus RB cord-024076-q9fw7ch1 47 2 , , , cord-024076-q9fw7ch1 47 3 the the DT cord-024076-q9fw7ch1 47 4 presence presence NN cord-024076-q9fw7ch1 47 5 of of IN cord-024076-q9fw7ch1 47 6 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 47 7 disease disease NN cord-024076-q9fw7ch1 47 8 may may MD cord-024076-q9fw7ch1 47 9 be be VB cord-024076-q9fw7ch1 47 10 a a DT cord-024076-q9fw7ch1 47 11 marker marker NN cord-024076-q9fw7ch1 47 12 of of IN cord-024076-q9fw7ch1 47 13 accelerated accelerated JJ cord-024076-q9fw7ch1 47 14 immunologic immunologic JJ cord-024076-q9fw7ch1 47 15 ageing ageing NN cord-024076-q9fw7ch1 47 16 / / SYM cord-024076-q9fw7ch1 47 17 dysregulation dysregulation NN cord-024076-q9fw7ch1 47 18 and and CC cord-024076-q9fw7ch1 47 19 relate relate VBP cord-024076-q9fw7ch1 47 20 indirectly indirectly RB cord-024076-q9fw7ch1 47 21 to to TO cord-024076-q9fw7ch1 47 22 COVID-19 covid-19 VB cord-024076-q9fw7ch1 47 23 prognosis.(12 prognosis.(12 CD cord-024076-q9fw7ch1 47 24 ) ) -RRB- cord-024076-q9fw7ch1 48 1 In in IN cord-024076-q9fw7ch1 48 2 South South NNP cord-024076-q9fw7ch1 48 3 Africa Africa NNP cord-024076-q9fw7ch1 48 4 , , , cord-024076-q9fw7ch1 48 5 hypertension hypertension NN cord-024076-q9fw7ch1 48 6 , , , cord-024076-q9fw7ch1 48 7 HFrEF HFrEF NNP cord-024076-q9fw7ch1 48 8 and and CC cord-024076-q9fw7ch1 48 9 diabetes diabete NNS cord-024076-q9fw7ch1 48 10 are be VBP cord-024076-q9fw7ch1 48 11 common common JJ cord-024076-q9fw7ch1 48 12 non non JJ cord-024076-q9fw7ch1 48 13 - - JJ cord-024076-q9fw7ch1 48 14 communicable communicable JJ cord-024076-q9fw7ch1 48 15 diseases disease NNS cord-024076-q9fw7ch1 48 16 , , , cord-024076-q9fw7ch1 48 17 and and CC cord-024076-q9fw7ch1 48 18 a a DT cord-024076-q9fw7ch1 48 19 significant significant JJ cord-024076-q9fw7ch1 48 20 proportion proportion NN cord-024076-q9fw7ch1 48 21 of of IN cord-024076-q9fw7ch1 48 22 patients patient NNS cord-024076-q9fw7ch1 48 23 are be VBP cord-024076-q9fw7ch1 48 24 being be VBG cord-024076-q9fw7ch1 48 25 treated treat VBN cord-024076-q9fw7ch1 48 26 with with IN cord-024076-q9fw7ch1 48 27 generic generic JJ cord-024076-q9fw7ch1 48 28 versions version NNS cord-024076-q9fw7ch1 48 29 of of IN cord-024076-q9fw7ch1 48 30 ACE ace NN cord-024076-q9fw7ch1 48 31 inhibitors inhibitor NNS cord-024076-q9fw7ch1 48 32 or or CC cord-024076-q9fw7ch1 48 33 ARBs arb NNS cord-024076-q9fw7ch1 48 34 . . . cord-024076-q9fw7ch1 49 1 There there EX cord-024076-q9fw7ch1 49 2 is be VBZ cord-024076-q9fw7ch1 49 3 extremely extremely RB cord-024076-q9fw7ch1 49 4 strong strong JJ cord-024076-q9fw7ch1 49 5 scientific scientific JJ cord-024076-q9fw7ch1 49 6 evidence evidence NN cord-024076-q9fw7ch1 49 7 for for IN cord-024076-q9fw7ch1 49 8 the the DT cord-024076-q9fw7ch1 49 9 benefit benefit NN cord-024076-q9fw7ch1 49 10 of of IN cord-024076-q9fw7ch1 49 11 RAAS RAAS NNP cord-024076-q9fw7ch1 49 12 inhibition inhibition NN cord-024076-q9fw7ch1 49 13 in in IN cord-024076-q9fw7ch1 49 14 patients patient NNS cord-024076-q9fw7ch1 49 15 with with IN cord-024076-q9fw7ch1 49 16 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 49 17 disease disease NN cord-024076-q9fw7ch1 49 18 . . . cord-024076-q9fw7ch1 50 1 In in IN cord-024076-q9fw7ch1 50 2 patients patient NNS cord-024076-q9fw7ch1 50 3 with with IN cord-024076-q9fw7ch1 50 4 HFrEF HFrEF NNP cord-024076-q9fw7ch1 50 5 , , , cord-024076-q9fw7ch1 50 6 RAAS RAAS NNP cord-024076-q9fw7ch1 50 7 inhibition inhibition NN cord-024076-q9fw7ch1 50 8 is be VBZ cord-024076-q9fw7ch1 50 9 a a DT cord-024076-q9fw7ch1 50 10 foundation foundation NN cord-024076-q9fw7ch1 50 11 of of IN cord-024076-q9fw7ch1 50 12 therapy therapy NN cord-024076-q9fw7ch1 50 13 for for IN cord-024076-q9fw7ch1 50 14 these these DT cord-024076-q9fw7ch1 50 15 patients patient NNS cord-024076-q9fw7ch1 50 16 . . . cord-024076-q9fw7ch1 51 1 Discontinuation discontinuation NN cord-024076-q9fw7ch1 51 2 of of IN cord-024076-q9fw7ch1 51 3 RAAS RAAS NNP cord-024076-q9fw7ch1 51 4 inhibition inhibition NN cord-024076-q9fw7ch1 51 5 in in IN cord-024076-q9fw7ch1 51 6 patients patient NNS cord-024076-q9fw7ch1 51 7 with with IN cord-024076-q9fw7ch1 51 8 heart heart NN cord-024076-q9fw7ch1 51 9 failure failure NN cord-024076-q9fw7ch1 51 10 can can MD cord-024076-q9fw7ch1 51 11 precipitate precipitate VB cord-024076-q9fw7ch1 51 12 clinical clinical JJ cord-024076-q9fw7ch1 51 13 deterioration deterioration NN cord-024076-q9fw7ch1 51 14 and and CC cord-024076-q9fw7ch1 51 15 may may MD cord-024076-q9fw7ch1 51 16 be be VB cord-024076-q9fw7ch1 51 17 associated associate VBN cord-024076-q9fw7ch1 51 18 with with IN cord-024076-q9fw7ch1 51 19 increased increase VBN cord-024076-q9fw7ch1 51 20 mortality mortality NN cord-024076-q9fw7ch1 51 21 . . . cord-024076-q9fw7ch1 52 1 ( ( -LRB- cord-024076-q9fw7ch1 52 2 14 14 CD cord-024076-q9fw7ch1 52 3 ) ) -RRB- cord-024076-q9fw7ch1 53 1 Furthermore furthermore RB cord-024076-q9fw7ch1 53 2 , , , cord-024076-q9fw7ch1 53 3 ACE ACE NNP cord-024076-q9fw7ch1 53 4 inhibitors inhibitor NNS cord-024076-q9fw7ch1 53 5 and and CC cord-024076-q9fw7ch1 53 6 ARBs arb NNS cord-024076-q9fw7ch1 53 7 are be VBP cord-024076-q9fw7ch1 53 8 common common JJ cord-024076-q9fw7ch1 53 9 therapies therapy NNS cord-024076-q9fw7ch1 53 10 for for IN cord-024076-q9fw7ch1 53 11 hypertension hypertension NN cord-024076-q9fw7ch1 53 12 and and CC cord-024076-q9fw7ch1 53 13 after after IN cord-024076-q9fw7ch1 53 14 myocardial myocardial JJ cord-024076-q9fw7ch1 53 15 infarction infarction NN cord-024076-q9fw7ch1 53 16 . . . cord-024076-q9fw7ch1 54 1 ( ( -LRB- cord-024076-q9fw7ch1 54 2 15 15 CD cord-024076-q9fw7ch1 54 3 , , , cord-024076-q9fw7ch1 54 4 16 16 CD cord-024076-q9fw7ch1 54 5 ) ) -RRB- cord-024076-q9fw7ch1 55 1 There there EX cord-024076-q9fw7ch1 55 2 is be VBZ cord-024076-q9fw7ch1 55 3 significant significant JJ cord-024076-q9fw7ch1 55 4 mortality mortality NN cord-024076-q9fw7ch1 55 5 benefit benefit NN cord-024076-q9fw7ch1 55 6 with with IN cord-024076-q9fw7ch1 55 7 all all DT cord-024076-q9fw7ch1 55 8 three three CD cord-024076-q9fw7ch1 55 9 classes class NNS cord-024076-q9fw7ch1 55 10 of of IN cord-024076-q9fw7ch1 55 11 these these DT cord-024076-q9fw7ch1 55 12 agents agent NNS cord-024076-q9fw7ch1 55 13 ' ' POS cord-024076-q9fw7ch1 55 14 post post JJ cord-024076-q9fw7ch1 55 15 myocardial myocardial JJ cord-024076-q9fw7ch1 55 16 infarction infarction NN cord-024076-q9fw7ch1 55 17 . . . cord-024076-q9fw7ch1 56 1 Based base VBN cord-024076-q9fw7ch1 56 2 on on IN cord-024076-q9fw7ch1 56 3 the the DT cord-024076-q9fw7ch1 56 4 solid solid JJ cord-024076-q9fw7ch1 56 5 scientific scientific JJ cord-024076-q9fw7ch1 56 6 foundation foundation NN cord-024076-q9fw7ch1 56 7 of of IN cord-024076-q9fw7ch1 56 8 these these DT cord-024076-q9fw7ch1 56 9 three three CD cord-024076-q9fw7ch1 56 10 agents agent NNS cord-024076-q9fw7ch1 56 11 in in IN cord-024076-q9fw7ch1 56 12 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 56 13 disease disease NN cord-024076-q9fw7ch1 56 14 , , , cord-024076-q9fw7ch1 56 15 diabetes diabetes NN cord-024076-q9fw7ch1 56 16 and and CC cord-024076-q9fw7ch1 56 17 renal renal JJ cord-024076-q9fw7ch1 56 18 disease disease NN cord-024076-q9fw7ch1 56 19 , , , cord-024076-q9fw7ch1 56 20 there there EX cord-024076-q9fw7ch1 56 21 is be VBZ cord-024076-q9fw7ch1 56 22 a a DT cord-024076-q9fw7ch1 56 23 potential potential NN cord-024076-q9fw7ch1 56 24 for for IN cord-024076-q9fw7ch1 56 25 significant significant JJ cord-024076-q9fw7ch1 56 26 adverse adverse JJ cord-024076-q9fw7ch1 56 27 outcomes outcome NNS cord-024076-q9fw7ch1 56 28 in in IN cord-024076-q9fw7ch1 56 29 discontinuing discontinue VBG cord-024076-q9fw7ch1 56 30 these these DT cord-024076-q9fw7ch1 56 31 agents agent NNS cord-024076-q9fw7ch1 56 32 . . . cord-024076-q9fw7ch1 57 1 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 57 2 appears appear VBZ cord-024076-q9fw7ch1 57 3 to to TO cord-024076-q9fw7ch1 57 4 be be VB cord-024076-q9fw7ch1 57 5 particularly particularly RB cord-024076-q9fw7ch1 57 6 severe severe JJ cord-024076-q9fw7ch1 57 7 in in IN cord-024076-q9fw7ch1 57 8 patients patient NNS cord-024076-q9fw7ch1 57 9 with with IN cord-024076-q9fw7ch1 57 10 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 57 11 disease disease NN cord-024076-q9fw7ch1 57 12 and and CC cord-024076-q9fw7ch1 57 13 may may MD cord-024076-q9fw7ch1 57 14 cause cause VB cord-024076-q9fw7ch1 57 15 myocarditis myocarditis NN cord-024076-q9fw7ch1 57 16 , , , cord-024076-q9fw7ch1 57 17 myocardial myocardial JJ cord-024076-q9fw7ch1 57 18 stress stress NN cord-024076-q9fw7ch1 57 19 and and CC cord-024076-q9fw7ch1 57 20 cardiomyopathy.(12 cardiomyopathy.(12 NN cord-024076-q9fw7ch1 57 21 ) ) -RRB- cord-024076-q9fw7ch1 58 1 Thus thus RB cord-024076-q9fw7ch1 58 2 , , , cord-024076-q9fw7ch1 58 3 discontinuing discontinue VBG cord-024076-q9fw7ch1 58 4 RAAS RAAS NNP cord-024076-q9fw7ch1 58 5 inhibition inhibition NN cord-024076-q9fw7ch1 58 6 in in IN cord-024076-q9fw7ch1 58 7 these these DT cord-024076-q9fw7ch1 58 8 high high JJ cord-024076-q9fw7ch1 58 9 - - HYPH cord-024076-q9fw7ch1 58 10 risk risk NN cord-024076-q9fw7ch1 58 11 patients patient NNS cord-024076-q9fw7ch1 58 12 can can MD cord-024076-q9fw7ch1 58 13 potentially potentially RB cord-024076-q9fw7ch1 58 14 lead lead VB cord-024076-q9fw7ch1 58 15 to to IN cord-024076-q9fw7ch1 58 16 higher high JJR cord-024076-q9fw7ch1 58 17 mortality mortality NN cord-024076-q9fw7ch1 58 18 . . . cord-024076-q9fw7ch1 59 1 Change change NN cord-024076-q9fw7ch1 59 2 of of IN cord-024076-q9fw7ch1 59 3 therapy therapy NN cord-024076-q9fw7ch1 59 4 for for IN cord-024076-q9fw7ch1 59 5 patients patient NNS cord-024076-q9fw7ch1 59 6 with with IN cord-024076-q9fw7ch1 59 7 hypertension hypertension NN cord-024076-q9fw7ch1 59 8 is be VBZ cord-024076-q9fw7ch1 59 9 less less RBR cord-024076-q9fw7ch1 59 10 risky risky JJ cord-024076-q9fw7ch1 59 11 . . . cord-024076-q9fw7ch1 60 1 However however RB cord-024076-q9fw7ch1 60 2 , , , cord-024076-q9fw7ch1 60 3 they -PRON- PRP cord-024076-q9fw7ch1 60 4 are be VBP cord-024076-q9fw7ch1 60 5 associated associate VBN cord-024076-q9fw7ch1 60 6 with with IN cord-024076-q9fw7ch1 60 7 other other JJ cord-024076-q9fw7ch1 60 8 risks risk NNS cord-024076-q9fw7ch1 60 9 such such JJ cord-024076-q9fw7ch1 60 10 as as IN cord-024076-q9fw7ch1 60 11 medication medication NN cord-024076-q9fw7ch1 60 12 errors error NNS cord-024076-q9fw7ch1 60 13 , , , cord-024076-q9fw7ch1 60 14 rebound rebound VB cord-024076-q9fw7ch1 60 15 increase increase NN cord-024076-q9fw7ch1 60 16 in in IN cord-024076-q9fw7ch1 60 17 blood blood NN cord-024076-q9fw7ch1 60 18 pressure pressure NN cord-024076-q9fw7ch1 60 19 , , , cord-024076-q9fw7ch1 60 20 frequent frequent JJ cord-024076-q9fw7ch1 60 21 monitoring monitoring NN cord-024076-q9fw7ch1 60 22 to to TO cord-024076-q9fw7ch1 60 23 assess assess VB cord-024076-q9fw7ch1 60 24 adequate adequate JJ cord-024076-q9fw7ch1 60 25 blood blood NN cord-024076-q9fw7ch1 60 26 pressure pressure NN cord-024076-q9fw7ch1 60 27 control control NN cord-024076-q9fw7ch1 60 28 and and CC cord-024076-q9fw7ch1 60 29 management management NN cord-024076-q9fw7ch1 60 30 of of IN cord-024076-q9fw7ch1 60 31 side side JJ cord-024076-q9fw7ch1 60 32 effects effect NNS cord-024076-q9fw7ch1 60 33 of of IN cord-024076-q9fw7ch1 60 34 newly newly RB cord-024076-q9fw7ch1 60 35 prescribed prescribe VBN cord-024076-q9fw7ch1 60 36 medications medication NNS cord-024076-q9fw7ch1 60 37 . . . cord-024076-q9fw7ch1 61 1 It -PRON- PRP cord-024076-q9fw7ch1 61 2 has have VBZ cord-024076-q9fw7ch1 61 3 been be VBN cord-024076-q9fw7ch1 61 4 shown show VBN cord-024076-q9fw7ch1 61 5 that that IN cord-024076-q9fw7ch1 61 6 even even RB cord-024076-q9fw7ch1 61 7 short short JJ cord-024076-q9fw7ch1 61 8 periods period NNS cord-024076-q9fw7ch1 61 9 of of IN cord-024076-q9fw7ch1 61 10 loss loss NN cord-024076-q9fw7ch1 61 11 of of IN cord-024076-q9fw7ch1 61 12 control control NN cord-024076-q9fw7ch1 61 13 of of IN cord-024076-q9fw7ch1 61 14 blood blood NN cord-024076-q9fw7ch1 61 15 pressure pressure NN cord-024076-q9fw7ch1 61 16 may may MD cord-024076-q9fw7ch1 61 17 be be VB cord-024076-q9fw7ch1 61 18 associated associate VBN cord-024076-q9fw7ch1 61 19 with with IN cord-024076-q9fw7ch1 61 20 increased increase VBN cord-024076-q9fw7ch1 61 21 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 61 22 risk risk NN cord-024076-q9fw7ch1 61 23 . . . cord-024076-q9fw7ch1 62 1 ( ( -LRB- cord-024076-q9fw7ch1 62 2 17 17 CD cord-024076-q9fw7ch1 62 3 ) ) -RRB- cord-024076-q9fw7ch1 63 1 In in IN cord-024076-q9fw7ch1 63 2 response response NN cord-024076-q9fw7ch1 63 3 to to IN cord-024076-q9fw7ch1 63 4 the the DT cord-024076-q9fw7ch1 63 5 reports report NNS cord-024076-q9fw7ch1 63 6 of of IN cord-024076-q9fw7ch1 63 7 a a DT cord-024076-q9fw7ch1 63 8 hypothetical hypothetical JJ cord-024076-q9fw7ch1 63 9 risk risk NN cord-024076-q9fw7ch1 63 10 of of IN cord-024076-q9fw7ch1 63 11 ACE ace NN cord-024076-q9fw7ch1 63 12 inhibitors inhibitor NNS cord-024076-q9fw7ch1 63 13 and and CC cord-024076-q9fw7ch1 63 14 ARBs arb NNS cord-024076-q9fw7ch1 63 15 , , , cord-024076-q9fw7ch1 63 16 many many JJ cord-024076-q9fw7ch1 63 17 societies society NNS cord-024076-q9fw7ch1 63 18 have have VBP cord-024076-q9fw7ch1 63 19 issued issue VBN cord-024076-q9fw7ch1 63 20 statements statement NNS cord-024076-q9fw7ch1 63 21 strongly strongly RB cord-024076-q9fw7ch1 63 22 recommending recommend VBG cord-024076-q9fw7ch1 63 23 the the DT cord-024076-q9fw7ch1 63 24 continuation continuation NN cord-024076-q9fw7ch1 63 25 of of IN cord-024076-q9fw7ch1 63 26 ACE ACE NNP cord-024076-q9fw7ch1 63 27 inhibitors inhibitor NNS cord-024076-q9fw7ch1 63 28 and and CC cord-024076-q9fw7ch1 63 29 ARB arb NN cord-024076-q9fw7ch1 63 30 therapies therapy NNS cord-024076-q9fw7ch1 63 31 . . . cord-024076-q9fw7ch1 64 1 ( ( -LRB- cord-024076-q9fw7ch1 64 2 18 18 CD cord-024076-q9fw7ch1 64 3 , , , cord-024076-q9fw7ch1 64 4 19 19 CD cord-024076-q9fw7ch1 64 5 ) ) -RRB- cord-024076-q9fw7ch1 64 6 Patients patient NNS cord-024076-q9fw7ch1 64 7 are be VBP cord-024076-q9fw7ch1 64 8 strongly strongly RB cord-024076-q9fw7ch1 64 9 discouraged discouraged JJ cord-024076-q9fw7ch1 64 10 from from IN cord-024076-q9fw7ch1 64 11 making make VBG cord-024076-q9fw7ch1 64 12 autonomous autonomous JJ cord-024076-q9fw7ch1 64 13 decisions decision NNS cord-024076-q9fw7ch1 64 14 about about IN cord-024076-q9fw7ch1 64 15 their -PRON- PRP$ cord-024076-q9fw7ch1 64 16 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 64 17 therapy therapy NN cord-024076-q9fw7ch1 64 18 and and CC cord-024076-q9fw7ch1 64 19 must must MD cord-024076-q9fw7ch1 64 20 be be VB cord-024076-q9fw7ch1 64 21 guided guide VBN cord-024076-q9fw7ch1 64 22 by by IN cord-024076-q9fw7ch1 64 23 their -PRON- PRP$ cord-024076-q9fw7ch1 64 24 informed inform VBN cord-024076-q9fw7ch1 64 25 treating treat VBG cord-024076-q9fw7ch1 64 26 physician physician NN cord-024076-q9fw7ch1 64 27 . . . cord-024076-q9fw7ch1 65 1 Moving move VBG cord-024076-q9fw7ch1 65 2 forward forward RB cord-024076-q9fw7ch1 65 3 it -PRON- PRP cord-024076-q9fw7ch1 65 4 is be VBZ cord-024076-q9fw7ch1 65 5 clear clear JJ cord-024076-q9fw7ch1 65 6 that that IN cord-024076-q9fw7ch1 65 7 more more JJR cord-024076-q9fw7ch1 65 8 research research NN cord-024076-q9fw7ch1 65 9 is be VBZ cord-024076-q9fw7ch1 65 10 needed need VBN cord-024076-q9fw7ch1 65 11 to to TO cord-024076-q9fw7ch1 65 12 clarify clarify VB cord-024076-q9fw7ch1 65 13 and and CC cord-024076-q9fw7ch1 65 14 understand understand VB cord-024076-q9fw7ch1 65 15 the the DT cord-024076-q9fw7ch1 65 16 relationship relationship NN cord-024076-q9fw7ch1 65 17 between between IN cord-024076-q9fw7ch1 65 18 the the DT cord-024076-q9fw7ch1 65 19 ACE ace NN cord-024076-q9fw7ch1 65 20 2 2 CD cord-024076-q9fw7ch1 65 21 protein protein NN cord-024076-q9fw7ch1 65 22 , , , cord-024076-q9fw7ch1 65 23 ACE ACE NNP cord-024076-q9fw7ch1 65 24 inhibitors inhibitor NNS cord-024076-q9fw7ch1 65 25 and and CC cord-024076-q9fw7ch1 65 26 ARB ARB NNP cord-024076-q9fw7ch1 65 27 use use NN cord-024076-q9fw7ch1 65 28 in in IN cord-024076-q9fw7ch1 65 29 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 65 30 disease disease NN cord-024076-q9fw7ch1 65 31 and and CC cord-024076-q9fw7ch1 65 32 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 65 33 prognosis prognosis NN cord-024076-q9fw7ch1 65 34 . . . cord-024076-q9fw7ch1 66 1 In in IN cord-024076-q9fw7ch1 66 2 this this DT cord-024076-q9fw7ch1 66 3 regard regard NN cord-024076-q9fw7ch1 66 4 an an DT cord-024076-q9fw7ch1 66 5 ongoing ongoing JJ cord-024076-q9fw7ch1 66 6 randomized randomized JJ cord-024076-q9fw7ch1 66 7 trial trial NN cord-024076-q9fw7ch1 66 8 evaluating evaluate VBG cord-024076-q9fw7ch1 66 9 recombinant recombinant JJ cord-024076-q9fw7ch1 66 10 ACE ACE NNP cord-024076-q9fw7ch1 66 11 2 2 CD cord-024076-q9fw7ch1 66 12 in in IN cord-024076-q9fw7ch1 66 13 the the DT cord-024076-q9fw7ch1 66 14 setting setting NN cord-024076-q9fw7ch1 66 15 of of IN cord-024076-q9fw7ch1 66 16 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 66 17 may may MD cord-024076-q9fw7ch1 66 18 help help VB cord-024076-q9fw7ch1 66 19 one one CD cord-024076-q9fw7ch1 66 20 to to TO cord-024076-q9fw7ch1 66 21 provide provide VB cord-024076-q9fw7ch1 66 22 mechanistic mechanistic JJ cord-024076-q9fw7ch1 66 23 information information NN cord-024076-q9fw7ch1 66 24 in in IN cord-024076-q9fw7ch1 66 25 patients patient NNS cord-024076-q9fw7ch1 66 26 infected infect VBN cord-024076-q9fw7ch1 66 27 with with IN cord-024076-q9fw7ch1 66 28 this this DT cord-024076-q9fw7ch1 66 29 virus virus NN cord-024076-q9fw7ch1 66 30 ( ( -LRB- cord-024076-q9fw7ch1 66 31 ClinicalTrials.gov ClinicalTrials.gov NNP cord-024076-q9fw7ch1 66 32 Identifier Identifier NNP cord-024076-q9fw7ch1 66 33 : : : cord-024076-q9fw7ch1 66 34 NCT04287686 NCT04287686 NNP cord-024076-q9fw7ch1 66 35 ) ) -RRB- cord-024076-q9fw7ch1 66 36 . . . cord-024076-q9fw7ch1 67 1 ( ( -LRB- cord-024076-q9fw7ch1 67 2 20 20 CD cord-024076-q9fw7ch1 67 3 ) ) -RRB- cord-024076-q9fw7ch1 68 1 This this DT cord-024076-q9fw7ch1 68 2 therapy therapy NN cord-024076-q9fw7ch1 68 3 has have VBZ cord-024076-q9fw7ch1 68 4 the the DT cord-024076-q9fw7ch1 68 5 possible possible JJ cord-024076-q9fw7ch1 68 6 potential potential NN cord-024076-q9fw7ch1 68 7 to to IN cord-024076-q9fw7ch1 68 8 both both DT cord-024076-q9fw7ch1 68 9 decrease decrease VB cord-024076-q9fw7ch1 68 10 viral viral JJ cord-024076-q9fw7ch1 68 11 load load NN cord-024076-q9fw7ch1 68 12 and and CC cord-024076-q9fw7ch1 68 13 ameliorate ameliorate VB cord-024076-q9fw7ch1 68 14 the the DT cord-024076-q9fw7ch1 68 15 harmful harmful JJ cord-024076-q9fw7ch1 68 16 effects effect NNS cord-024076-q9fw7ch1 68 17 of of IN cord-024076-q9fw7ch1 68 18 angiotensin angiotensin NN cord-024076-q9fw7ch1 68 19 II II NNP cord-024076-q9fw7ch1 68 20 . . . cord-024076-q9fw7ch1 69 1 Until until IN cord-024076-q9fw7ch1 69 2 more more RBR cord-024076-q9fw7ch1 69 3 robust robust JJ cord-024076-q9fw7ch1 69 4 evidence evidence NN cord-024076-q9fw7ch1 69 5 is be VBZ cord-024076-q9fw7ch1 69 6 available available JJ cord-024076-q9fw7ch1 69 7 , , , cord-024076-q9fw7ch1 69 8 it -PRON- PRP cord-024076-q9fw7ch1 69 9 is be VBZ cord-024076-q9fw7ch1 69 10 prudent prudent JJ cord-024076-q9fw7ch1 69 11 to to TO cord-024076-q9fw7ch1 69 12 advise advise VB cord-024076-q9fw7ch1 69 13 that that IN cord-024076-q9fw7ch1 69 14 ACE ace NN cord-024076-q9fw7ch1 69 15 inhibitors inhibitor NNS cord-024076-q9fw7ch1 69 16 or or CC cord-024076-q9fw7ch1 69 17 ARB arb NN cord-024076-q9fw7ch1 69 18 therapy therapy NN cord-024076-q9fw7ch1 69 19 should should MD cord-024076-q9fw7ch1 69 20 be be VB cord-024076-q9fw7ch1 69 21 continued continue VBN cord-024076-q9fw7ch1 69 22 in in IN cord-024076-q9fw7ch1 69 23 patients patient NNS cord-024076-q9fw7ch1 69 24 who who WP cord-024076-q9fw7ch1 69 25 are be VBP cord-024076-q9fw7ch1 69 26 at at IN cord-024076-q9fw7ch1 69 27 risk risk NN cord-024076-q9fw7ch1 69 28 for for IN cord-024076-q9fw7ch1 69 29 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 69 30 infection infection NN cord-024076-q9fw7ch1 69 31 or or CC cord-024076-q9fw7ch1 69 32 who who WP cord-024076-q9fw7ch1 69 33 have have VBP cord-024076-q9fw7ch1 69 34 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 69 35 infection infection NN cord-024076-q9fw7ch1 69 36 . . . cord-024076-q9fw7ch1 70 1 Even even RB cord-024076-q9fw7ch1 70 2 in in IN cord-024076-q9fw7ch1 70 3 patients patient NNS cord-024076-q9fw7ch1 70 4 with with IN cord-024076-q9fw7ch1 70 5 current current JJ cord-024076-q9fw7ch1 70 6 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 70 7 infection infection NN cord-024076-q9fw7ch1 70 8 , , , cord-024076-q9fw7ch1 70 9 ACE ACE NNP cord-024076-q9fw7ch1 70 10 inhibitors inhibitor NNS cord-024076-q9fw7ch1 70 11 or or CC cord-024076-q9fw7ch1 70 12 ARB ARB NNP cord-024076-q9fw7ch1 70 13 should should MD cord-024076-q9fw7ch1 70 14 be be VB cord-024076-q9fw7ch1 70 15 initiated initiate VBN cord-024076-q9fw7ch1 70 16 in in IN cord-024076-q9fw7ch1 70 17 guideline guideline NN cord-024076-q9fw7ch1 70 18 - - HYPH cord-024076-q9fw7ch1 70 19 indicated indicate VBN cord-024076-q9fw7ch1 70 20 conditions condition NNS cord-024076-q9fw7ch1 70 21 such such JJ cord-024076-q9fw7ch1 70 22 as as IN cord-024076-q9fw7ch1 70 23 in in IN cord-024076-q9fw7ch1 70 24 patients patient NNS cord-024076-q9fw7ch1 70 25 with with IN cord-024076-q9fw7ch1 70 26 heart heart NN cord-024076-q9fw7ch1 70 27 failure failure NN cord-024076-q9fw7ch1 70 28 or or CC cord-024076-q9fw7ch1 70 29 myocardial myocardial JJ cord-024076-q9fw7ch1 70 30 infarction infarction NN cord-024076-q9fw7ch1 70 31 . . . cord-024076-q9fw7ch1 71 1 We -PRON- PRP cord-024076-q9fw7ch1 71 2 must must MD cord-024076-q9fw7ch1 71 3 not not RB cord-024076-q9fw7ch1 71 4 draw draw VB cord-024076-q9fw7ch1 71 5 inappropriate inappropriate JJ cord-024076-q9fw7ch1 71 6 conclusions conclusion NNS cord-024076-q9fw7ch1 71 7 from from IN cord-024076-q9fw7ch1 71 8 observational observational JJ cord-024076-q9fw7ch1 71 9 studies study NNS cord-024076-q9fw7ch1 71 10 . . . cord-024076-q9fw7ch1 72 1 In in IN cord-024076-q9fw7ch1 72 2 conclusion conclusion NN cord-024076-q9fw7ch1 72 3 , , , cord-024076-q9fw7ch1 72 4 in in IN cord-024076-q9fw7ch1 72 5 the the DT cord-024076-q9fw7ch1 72 6 current current JJ cord-024076-q9fw7ch1 72 7 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 72 8 pandemic pandemic NN cord-024076-q9fw7ch1 72 9 in in IN cord-024076-q9fw7ch1 72 10 South South NNP cord-024076-q9fw7ch1 72 11 Africa Africa NNP cord-024076-q9fw7ch1 72 12 , , , cord-024076-q9fw7ch1 72 13 both both DT cord-024076-q9fw7ch1 72 14 practitioners practitioner NNS cord-024076-q9fw7ch1 72 15 and and CC cord-024076-q9fw7ch1 72 16 patients patient NNS cord-024076-q9fw7ch1 72 17 need need VBP cord-024076-q9fw7ch1 72 18 to to TO cord-024076-q9fw7ch1 72 19 be be VB cord-024076-q9fw7ch1 72 20 advised advise VBN cord-024076-q9fw7ch1 72 21 that that IN cord-024076-q9fw7ch1 72 22 ACE ACE NNP cord-024076-q9fw7ch1 72 23 inhibitors inhibitor NNS cord-024076-q9fw7ch1 72 24 and and CC cord-024076-q9fw7ch1 72 25 ARB arb NN cord-024076-q9fw7ch1 72 26 therapy therapy NN cord-024076-q9fw7ch1 72 27 should should MD cord-024076-q9fw7ch1 72 28 be be VB cord-024076-q9fw7ch1 72 29 continued continue VBN cord-024076-q9fw7ch1 72 30 in in IN cord-024076-q9fw7ch1 72 31 patients patient NNS cord-024076-q9fw7ch1 72 32 with with IN cord-024076-q9fw7ch1 72 33 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 72 34 disease disease NN cord-024076-q9fw7ch1 72 35 and and CC cord-024076-q9fw7ch1 72 36 in in IN cord-024076-q9fw7ch1 72 37 associated associated JJ cord-024076-q9fw7ch1 72 38 conditions condition NNS cord-024076-q9fw7ch1 72 39 such such JJ cord-024076-q9fw7ch1 72 40 as as IN cord-024076-q9fw7ch1 72 41 diabetes diabetes NN cord-024076-q9fw7ch1 72 42 and and CC cord-024076-q9fw7ch1 72 43 renal renal JJ cord-024076-q9fw7ch1 72 44 disease disease NN cord-024076-q9fw7ch1 72 45 . . . cord-024076-q9fw7ch1 73 1 Ongoing ongoing JJ cord-024076-q9fw7ch1 73 2 research research NN cord-024076-q9fw7ch1 73 3 efforts effort NNS cord-024076-q9fw7ch1 73 4 need need VBP cord-024076-q9fw7ch1 73 5 to to TO cord-024076-q9fw7ch1 73 6 concentrate concentrate VB cord-024076-q9fw7ch1 73 7 on on IN cord-024076-q9fw7ch1 73 8 assessing assess VBG cord-024076-q9fw7ch1 73 9 the the DT cord-024076-q9fw7ch1 73 10 role role NN cord-024076-q9fw7ch1 73 11 of of IN cord-024076-q9fw7ch1 73 12 ACE ACE NNP cord-024076-q9fw7ch1 73 13 2 2 CD cord-024076-q9fw7ch1 73 14 in in IN cord-024076-q9fw7ch1 73 15 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 73 16 infection infection NN cord-024076-q9fw7ch1 73 17 and and CC cord-024076-q9fw7ch1 73 18 the the DT cord-024076-q9fw7ch1 73 19 effect effect NN cord-024076-q9fw7ch1 73 20 on on IN cord-024076-q9fw7ch1 73 21 mortality mortality NN cord-024076-q9fw7ch1 73 22 of of IN cord-024076-q9fw7ch1 73 23 known know VBN cord-024076-q9fw7ch1 73 24 therapies therapy NNS cord-024076-q9fw7ch1 73 25 for for IN cord-024076-q9fw7ch1 73 26 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 73 27 disease disease NN cord-024076-q9fw7ch1 73 28 such such JJ cord-024076-q9fw7ch1 73 29 as as IN cord-024076-q9fw7ch1 73 30 ACE ace NN cord-024076-q9fw7ch1 73 31 inhibitors inhibitor NNS cord-024076-q9fw7ch1 73 32 and and CC cord-024076-q9fw7ch1 73 33 ARBs arb NNS cord-024076-q9fw7ch1 73 34 . . . cord-024076-q9fw7ch1 74 1 It -PRON- PRP cord-024076-q9fw7ch1 74 2 is be VBZ cord-024076-q9fw7ch1 74 3 hoped hope VBN cord-024076-q9fw7ch1 74 4 that that IN cord-024076-q9fw7ch1 74 5 with with IN cord-024076-q9fw7ch1 74 6 the the DT cord-024076-q9fw7ch1 74 7 large large JJ cord-024076-q9fw7ch1 74 8 numbers number NNS cord-024076-q9fw7ch1 74 9 of of IN cord-024076-q9fw7ch1 74 10 patients patient NNS cord-024076-q9fw7ch1 74 11 currently currently RB cord-024076-q9fw7ch1 74 12 infected infect VBN cord-024076-q9fw7ch1 74 13 worldwide worldwide RB cord-024076-q9fw7ch1 74 14 with with IN cord-024076-q9fw7ch1 74 15 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 74 16 , , , cord-024076-q9fw7ch1 74 17 this this DT cord-024076-q9fw7ch1 74 18 information information NN cord-024076-q9fw7ch1 74 19 will will MD cord-024076-q9fw7ch1 74 20 be be VB cord-024076-q9fw7ch1 74 21 elucidated elucidate VBN cord-024076-q9fw7ch1 74 22 in in IN cord-024076-q9fw7ch1 74 23 the the DT cord-024076-q9fw7ch1 74 24 near near JJ cord-024076-q9fw7ch1 74 25 future future NN cord-024076-q9fw7ch1 74 26 . . . cord-024076-q9fw7ch1 75 1 Preventing prevent VBG cord-024076-q9fw7ch1 75 2 a a DT cord-024076-q9fw7ch1 75 3 Covid-19 covid-19 NN cord-024076-q9fw7ch1 75 4 pandemic pandemic NN cord-024076-q9fw7ch1 75 5 : : : cord-024076-q9fw7ch1 75 6 ACE ace NN cord-024076-q9fw7ch1 75 7 inhibitors inhibitor NNS cord-024076-q9fw7ch1 75 8 as as IN cord-024076-q9fw7ch1 75 9 a a DT cord-024076-q9fw7ch1 75 10 potential potential JJ cord-024076-q9fw7ch1 75 11 risk risk NN cord-024076-q9fw7ch1 75 12 factor factor NN cord-024076-q9fw7ch1 75 13 for for IN cord-024076-q9fw7ch1 75 14 fatal fatal JJ cord-024076-q9fw7ch1 75 15 Covid-19 covid-19 NN cord-024076-q9fw7ch1 75 16 Are be VBP cord-024076-q9fw7ch1 75 17 patients patient NNS cord-024076-q9fw7ch1 75 18 with with IN cord-024076-q9fw7ch1 75 19 hypertension hypertension NN cord-024076-q9fw7ch1 75 20 and and CC cord-024076-q9fw7ch1 75 21 diabetes diabetes NN cord-024076-q9fw7ch1 75 22 mellitus mellitus NN cord-024076-q9fw7ch1 75 23 at at IN cord-024076-q9fw7ch1 75 24 increased increase VBN cord-024076-q9fw7ch1 75 25 risk risk NN cord-024076-q9fw7ch1 75 26 for for IN cord-024076-q9fw7ch1 75 27 COVID-19 covid-19 JJ cord-024076-q9fw7ch1 75 28 infection infection NN cord-024076-q9fw7ch1 75 29 ? ? . cord-024076-q9fw7ch1 76 1 Clinical clinical JJ cord-024076-q9fw7ch1 76 2 characteristics characteristic NNS cord-024076-q9fw7ch1 76 3 of of IN cord-024076-q9fw7ch1 76 4 coronavirus coronavirus NN cord-024076-q9fw7ch1 76 5 disease disease NN cord-024076-q9fw7ch1 76 6 2019 2019 CD cord-024076-q9fw7ch1 76 7 in in IN cord-024076-q9fw7ch1 76 8 China China NNP cord-024076-q9fw7ch1 76 9 Angiotensin Angiotensin NNP cord-024076-q9fw7ch1 76 10 - - HYPH cord-024076-q9fw7ch1 76 11 converting convert VBG cord-024076-q9fw7ch1 76 12 enzyme enzyme NN cord-024076-q9fw7ch1 76 13 2 2 CD cord-024076-q9fw7ch1 76 14 is be VBZ cord-024076-q9fw7ch1 76 15 a a DT cord-024076-q9fw7ch1 76 16 functional functional JJ cord-024076-q9fw7ch1 76 17 receptor receptor NN cord-024076-q9fw7ch1 76 18 for for IN cord-024076-q9fw7ch1 76 19 coronavirus coronavirus NN cord-024076-q9fw7ch1 77 1 A a DT cord-024076-q9fw7ch1 77 2 pneumonia pneumonia NN cord-024076-q9fw7ch1 77 3 outbreak outbreak NN cord-024076-q9fw7ch1 77 4 associated associate VBN cord-024076-q9fw7ch1 77 5 with with IN cord-024076-q9fw7ch1 77 6 a a DT cord-024076-q9fw7ch1 77 7 new new JJ cord-024076-q9fw7ch1 77 8 coronavirus coronavirus NN cord-024076-q9fw7ch1 77 9 of of IN cord-024076-q9fw7ch1 77 10 probable probable JJ cord-024076-q9fw7ch1 77 11 bat bat NN cord-024076-q9fw7ch1 77 12 origin origin NN cord-024076-q9fw7ch1 77 13 Clinical clinical JJ cord-024076-q9fw7ch1 77 14 and and CC cord-024076-q9fw7ch1 77 15 biochemical biochemical JJ cord-024076-q9fw7ch1 77 16 indexes index NNS cord-024076-q9fw7ch1 77 17 from from IN cord-024076-q9fw7ch1 77 18 2019-nCoV 2019-ncov CD cord-024076-q9fw7ch1 77 19 infected infect VBN cord-024076-q9fw7ch1 77 20 patients patient NNS cord-024076-q9fw7ch1 77 21 linked link VBN cord-024076-q9fw7ch1 77 22 to to IN cord-024076-q9fw7ch1 77 23 viral viral JJ cord-024076-q9fw7ch1 77 24 loads load NNS cord-024076-q9fw7ch1 77 25 and and CC cord-024076-q9fw7ch1 77 26 lung lung NN cord-024076-q9fw7ch1 77 27 injury injury NN cord-024076-q9fw7ch1 77 28 Effect Effect NNP cord-024076-q9fw7ch1 77 29 of of IN cord-024076-q9fw7ch1 77 30 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 31 - - HYPH cord-024076-q9fw7ch1 77 32 converting convert VBG cord-024076-q9fw7ch1 77 33 - - HYPH cord-024076-q9fw7ch1 77 34 enzyme enzyme NN cord-024076-q9fw7ch1 77 35 inhibition inhibition NN cord-024076-q9fw7ch1 77 36 and and CC cord-024076-q9fw7ch1 77 37 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 38 II ii CD cord-024076-q9fw7ch1 77 39 receptor receptor NN cord-024076-q9fw7ch1 77 40 blockers blocker NNS cord-024076-q9fw7ch1 77 41 on on IN cord-024076-q9fw7ch1 77 42 cardiac cardiac JJ cord-024076-q9fw7ch1 77 43 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 44 - - HYPH cord-024076-q9fw7ch1 77 45 converting convert VBG cord-024076-q9fw7ch1 77 46 enzyme enzyme NN cord-024076-q9fw7ch1 77 47 2 2 CD cord-024076-q9fw7ch1 77 48 Urinary urinary JJ cord-024076-q9fw7ch1 77 49 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 50 - - HYPH cord-024076-q9fw7ch1 77 51 converting convert VBG cord-024076-q9fw7ch1 77 52 enzyme enzyme NN cord-024076-q9fw7ch1 77 53 2 2 CD cord-024076-q9fw7ch1 77 54 in in IN cord-024076-q9fw7ch1 77 55 hypertensive hypertensive JJ cord-024076-q9fw7ch1 77 56 patients patient NNS cord-024076-q9fw7ch1 77 57 may may MD cord-024076-q9fw7ch1 77 58 be be VB cord-024076-q9fw7ch1 77 59 increased increase VBN cord-024076-q9fw7ch1 77 60 by by IN cord-024076-q9fw7ch1 77 61 olmesartan olmesartan NNP cord-024076-q9fw7ch1 77 62 , , , cord-024076-q9fw7ch1 77 63 an an DT cord-024076-q9fw7ch1 77 64 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 65 II II NNP cord-024076-q9fw7ch1 77 66 receptor receptor NN cord-024076-q9fw7ch1 77 67 blocker blocker NN cord-024076-q9fw7ch1 77 68 A a DT cord-024076-q9fw7ch1 77 69 crucial crucial JJ cord-024076-q9fw7ch1 77 70 role role NN cord-024076-q9fw7ch1 77 71 of of IN cord-024076-q9fw7ch1 77 72 angiotensin angiotensin NN cord-024076-q9fw7ch1 77 73 converting convert VBG cord-024076-q9fw7ch1 77 74 enzyme enzyme NN cord-024076-q9fw7ch1 77 75 2 2 CD cord-024076-q9fw7ch1 77 76 ( ( -LRB- cord-024076-q9fw7ch1 77 77 ACE2 ACE2 NNP cord-024076-q9fw7ch1 77 78 ) ) -RRB- cord-024076-q9fw7ch1 77 79 in in IN cord-024076-q9fw7ch1 77 80 SARS SARS NNP cord-024076-q9fw7ch1 77 81 coronavirus coronavirus NN cord-024076-q9fw7ch1 77 82 - - HYPH cord-024076-q9fw7ch1 77 83 induced induce VBN cord-024076-q9fw7ch1 77 84 lung lung NN cord-024076-q9fw7ch1 77 85 injury injury NN cord-024076-q9fw7ch1 77 86 Pathology pathology NN cord-024076-q9fw7ch1 77 87 and and CC cord-024076-q9fw7ch1 77 88 pathogenesis pathogenesis NN cord-024076-q9fw7ch1 77 89 of of IN cord-024076-q9fw7ch1 77 90 severe severe JJ cord-024076-q9fw7ch1 77 91 acute acute JJ cord-024076-q9fw7ch1 77 92 respiratory respiratory JJ cord-024076-q9fw7ch1 77 93 syndrome syndrome NN cord-024076-q9fw7ch1 77 94 SARS SARS NNP cord-024076-q9fw7ch1 77 95 - - HYPH cord-024076-q9fw7ch1 77 96 CoV2 CoV2 NNP cord-024076-q9fw7ch1 77 97 : : : cord-024076-q9fw7ch1 78 1 should should MD cord-024076-q9fw7ch1 78 2 inhibitors inhibitor NNS cord-024076-q9fw7ch1 78 3 of of IN cord-024076-q9fw7ch1 78 4 the the DT cord-024076-q9fw7ch1 78 5 renin renin NN cord-024076-q9fw7ch1 78 6 - - HYPH cord-024076-q9fw7ch1 78 7 angiotensin angiotensin NN cord-024076-q9fw7ch1 78 8 system system NN cord-024076-q9fw7ch1 78 9 be be VB cord-024076-q9fw7ch1 78 10 withdrawn withdraw VBN cord-024076-q9fw7ch1 78 11 in in IN cord-024076-q9fw7ch1 78 12 patients patient NNS cord-024076-q9fw7ch1 78 13 with with IN cord-024076-q9fw7ch1 78 14 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 78 15 ? ? . cord-024076-q9fw7ch1 79 1 Cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 79 2 considerations consideration NNS cord-024076-q9fw7ch1 79 3 for for IN cord-024076-q9fw7ch1 79 4 patients patient NNS cord-024076-q9fw7ch1 79 5 , , , cord-024076-q9fw7ch1 79 6 health health NN cord-024076-q9fw7ch1 79 7 care care NN cord-024076-q9fw7ch1 79 8 workers worker NNS cord-024076-q9fw7ch1 79 9 , , , cord-024076-q9fw7ch1 79 10 and and CC cord-024076-q9fw7ch1 79 11 health health NN cord-024076-q9fw7ch1 79 12 systems system NNS cord-024076-q9fw7ch1 79 13 during during IN cord-024076-q9fw7ch1 79 14 the the DT cord-024076-q9fw7ch1 79 15 coronavirus coronavirus NN cord-024076-q9fw7ch1 79 16 disease disease NN cord-024076-q9fw7ch1 79 17 2019 2019 CD cord-024076-q9fw7ch1 79 18 ( ( -LRB- cord-024076-q9fw7ch1 79 19 COVID-19 covid-19 VB cord-024076-q9fw7ch1 79 20 ) ) -RRB- cord-024076-q9fw7ch1 79 21 pandemic pandemic NN cord-024076-q9fw7ch1 79 22 Inflammation inflammation NN cord-024076-q9fw7ch1 79 23 in in IN cord-024076-q9fw7ch1 79 24 atherosclerosis atherosclerosis NN cord-024076-q9fw7ch1 79 25 : : : cord-024076-q9fw7ch1 79 26 from from IN cord-024076-q9fw7ch1 79 27 pathophysiology pathophysiology NN cord-024076-q9fw7ch1 79 28 to to TO cord-024076-q9fw7ch1 79 29 practice practice VB cord-024076-q9fw7ch1 79 30 Withdrawal withdrawal NN cord-024076-q9fw7ch1 79 31 of of IN cord-024076-q9fw7ch1 79 32 pharmacological pharmacological JJ cord-024076-q9fw7ch1 79 33 treatment treatment NN cord-024076-q9fw7ch1 79 34 for for IN cord-024076-q9fw7ch1 79 35 heart heart NN cord-024076-q9fw7ch1 79 36 failure failure NN cord-024076-q9fw7ch1 79 37 in in IN cord-024076-q9fw7ch1 79 38 patients patient NNS cord-024076-q9fw7ch1 79 39 with with IN cord-024076-q9fw7ch1 79 40 recovered recovered JJ cord-024076-q9fw7ch1 79 41 dilated dilated JJ cord-024076-q9fw7ch1 79 42 cardiomyopathy cardiomyopathy NN cord-024076-q9fw7ch1 79 43 ( ( -LRB- cord-024076-q9fw7ch1 79 44 TRED TRED NNP cord-024076-q9fw7ch1 79 45 - - HYPH cord-024076-q9fw7ch1 79 46 HF HF NNP cord-024076-q9fw7ch1 79 47 ) ) -RRB- cord-024076-q9fw7ch1 79 48 : : : cord-024076-q9fw7ch1 79 49 an an DT cord-024076-q9fw7ch1 79 50 open open JJ cord-024076-q9fw7ch1 79 51 - - HYPH cord-024076-q9fw7ch1 79 52 label label NN cord-024076-q9fw7ch1 79 53 , , , cord-024076-q9fw7ch1 79 54 pilot pilot NN cord-024076-q9fw7ch1 79 55 , , , cord-024076-q9fw7ch1 79 56 randomised randomised JJ cord-024076-q9fw7ch1 79 57 trial trial NN cord-024076-q9fw7ch1 79 58 ESC ESC NNP cord-024076-q9fw7ch1 79 59 / / SYM cord-024076-q9fw7ch1 79 60 ESH ESH NNP cord-024076-q9fw7ch1 79 61 Guidelines Guidelines NNPS cord-024076-q9fw7ch1 79 62 for for IN cord-024076-q9fw7ch1 79 63 the the DT cord-024076-q9fw7ch1 79 64 management management NN cord-024076-q9fw7ch1 79 65 of of IN cord-024076-q9fw7ch1 79 66 arterial arterial JJ cord-024076-q9fw7ch1 79 67 hypertension hypertension NN cord-024076-q9fw7ch1 79 68 : : : cord-024076-q9fw7ch1 79 69 The the DT cord-024076-q9fw7ch1 79 70 Task Task NNP cord-024076-q9fw7ch1 79 71 Force Force NNP cord-024076-q9fw7ch1 79 72 for for IN cord-024076-q9fw7ch1 79 73 the the DT cord-024076-q9fw7ch1 79 74 management management NN cord-024076-q9fw7ch1 79 75 of of IN cord-024076-q9fw7ch1 79 76 arterial arterial JJ cord-024076-q9fw7ch1 79 77 hypertension hypertension NN cord-024076-q9fw7ch1 79 78 of of IN cord-024076-q9fw7ch1 79 79 the the DT cord-024076-q9fw7ch1 79 80 European European NNP cord-024076-q9fw7ch1 79 81 Society Society NNP cord-024076-q9fw7ch1 79 82 of of IN cord-024076-q9fw7ch1 79 83 Cardiology Cardiology NNP cord-024076-q9fw7ch1 79 84 ( ( -LRB- cord-024076-q9fw7ch1 79 85 ESC ESC NNP cord-024076-q9fw7ch1 79 86 ) ) -RRB- cord-024076-q9fw7ch1 79 87 and and CC cord-024076-q9fw7ch1 79 88 the the DT cord-024076-q9fw7ch1 79 89 European European NNP cord-024076-q9fw7ch1 79 90 Society Society NNP cord-024076-q9fw7ch1 79 91 of of IN cord-024076-q9fw7ch1 79 92 Hypertension Hypertension NNP cord-024076-q9fw7ch1 80 1 ( ( -LRB- cord-024076-q9fw7ch1 80 2 ESH ESH NNP cord-024076-q9fw7ch1 80 3 ) ) -RRB- cord-024076-q9fw7ch1 80 4 ESC ESC NNP cord-024076-q9fw7ch1 80 5 Guidelines Guidelines NNPS cord-024076-q9fw7ch1 80 6 for for IN cord-024076-q9fw7ch1 80 7 the the DT cord-024076-q9fw7ch1 80 8 management management NN cord-024076-q9fw7ch1 80 9 of of IN cord-024076-q9fw7ch1 80 10 acute acute JJ cord-024076-q9fw7ch1 80 11 myocardial myocardial JJ cord-024076-q9fw7ch1 80 12 infarction infarction NN cord-024076-q9fw7ch1 80 13 in in IN cord-024076-q9fw7ch1 80 14 patients patient NNS cord-024076-q9fw7ch1 80 15 presenting present VBG cord-024076-q9fw7ch1 80 16 with with IN cord-024076-q9fw7ch1 80 17 ST ST NNP cord-024076-q9fw7ch1 80 18 - - HYPH cord-024076-q9fw7ch1 80 19 segment segment NN cord-024076-q9fw7ch1 80 20 elevation elevation NN cord-024076-q9fw7ch1 80 21 : : : cord-024076-q9fw7ch1 80 22 the the DT cord-024076-q9fw7ch1 80 23 Task Task NNP cord-024076-q9fw7ch1 80 24 Force Force NNP cord-024076-q9fw7ch1 80 25 for for IN cord-024076-q9fw7ch1 80 26 the the DT cord-024076-q9fw7ch1 80 27 management management NN cord-024076-q9fw7ch1 80 28 of of IN cord-024076-q9fw7ch1 80 29 acute acute JJ cord-024076-q9fw7ch1 80 30 myocardial myocardial JJ cord-024076-q9fw7ch1 80 31 infarction infarction NN cord-024076-q9fw7ch1 80 32 in in IN cord-024076-q9fw7ch1 80 33 patients patient NNS cord-024076-q9fw7ch1 80 34 presenting present VBG cord-024076-q9fw7ch1 80 35 with with IN cord-024076-q9fw7ch1 80 36 ST ST NNP cord-024076-q9fw7ch1 80 37 - - HYPH cord-024076-q9fw7ch1 80 38 segment segment NN cord-024076-q9fw7ch1 80 39 elevation elevation NN cord-024076-q9fw7ch1 80 40 of of IN cord-024076-q9fw7ch1 80 41 the the DT cord-024076-q9fw7ch1 80 42 European European NNP cord-024076-q9fw7ch1 80 43 Society Society NNP cord-024076-q9fw7ch1 80 44 of of IN cord-024076-q9fw7ch1 80 45 Cardiology Cardiology NNP cord-024076-q9fw7ch1 80 46 Outcomes Outcomes NNPS cord-024076-q9fw7ch1 80 47 in in IN cord-024076-q9fw7ch1 80 48 hypertensive hypertensive JJ cord-024076-q9fw7ch1 80 49 patients patient NNS cord-024076-q9fw7ch1 80 50 at at IN cord-024076-q9fw7ch1 80 51 high high JJ cord-024076-q9fw7ch1 80 52 cardiovascular cardiovascular JJ cord-024076-q9fw7ch1 80 53 risk risk NN cord-024076-q9fw7ch1 80 54 treated treat VBN cord-024076-q9fw7ch1 80 55 with with IN cord-024076-q9fw7ch1 80 56 regimens regimen NNS cord-024076-q9fw7ch1 80 57 based base VBN cord-024076-q9fw7ch1 80 58 on on IN cord-024076-q9fw7ch1 80 59 valsartan valsartan NNP cord-024076-q9fw7ch1 80 60 or or CC cord-024076-q9fw7ch1 80 61 amlodipine amlodipine NN cord-024076-q9fw7ch1 80 62 : : : cord-024076-q9fw7ch1 80 63 the the DT cord-024076-q9fw7ch1 80 64 VALUE value NN cord-024076-q9fw7ch1 80 65 randomised randomised JJ cord-024076-q9fw7ch1 80 66 trial trial NN cord-024076-q9fw7ch1 80 67 Position Position NNP cord-024076-q9fw7ch1 80 68 statement statement NN cord-024076-q9fw7ch1 80 69 of of IN cord-024076-q9fw7ch1 80 70 the the DT cord-024076-q9fw7ch1 80 71 ESC ESC NNP cord-024076-q9fw7ch1 80 72 Council Council NNP cord-024076-q9fw7ch1 80 73 on on IN cord-024076-q9fw7ch1 80 74 Hypertension Hypertension NNP cord-024076-q9fw7ch1 80 75 on on IN cord-024076-q9fw7ch1 80 76 ACE ace NN cord-024076-q9fw7ch1 80 77 - - HYPH cord-024076-q9fw7ch1 80 78 inhibitors inhibitor NNS cord-024076-q9fw7ch1 80 79 and and CC cord-024076-q9fw7ch1 80 80 angiotensin angiotensin NN cord-024076-q9fw7ch1 80 81 receptor receptor NN cord-024076-q9fw7ch1 80 82 blockers blocker NNS cord-024076-q9fw7ch1 81 1 HFSA HFSA NNP cord-024076-q9fw7ch1 81 2 / / SYM cord-024076-q9fw7ch1 81 3 ACC ACC NNP cord-024076-q9fw7ch1 81 4 / / SYM cord-024076-q9fw7ch1 81 5 AHA AHA NNP cord-024076-q9fw7ch1 81 6 statement statement NN cord-024076-q9fw7ch1 81 7 addresses address VBZ cord-024076-q9fw7ch1 81 8 concerns concern NNS cord-024076-q9fw7ch1 81 9 re re IN cord-024076-q9fw7ch1 81 10 : : : cord-024076-q9fw7ch1 81 11 using use VBG cord-024076-q9fw7ch1 81 12 RAAS RAAS NNP cord-024076-q9fw7ch1 81 13 antagonists antagonist NNS cord-024076-q9fw7ch1 81 14 in in IN cord-024076-q9fw7ch1 81 15 COVID-19 COVID-19 NNP cord-024076-q9fw7ch1 81 16 Angiotensin Angiotensin NNP cord-024076-q9fw7ch1 81 17 - - HYPH cord-024076-q9fw7ch1 81 18 converting convert VBG cord-024076-q9fw7ch1 81 19 enzyme enzyme NN cord-024076-q9fw7ch1 81 20 2 2 CD cord-024076-q9fw7ch1 81 21 ( ( -LRB- cord-024076-q9fw7ch1 81 22 ACE2 ACE2 NNP cord-024076-q9fw7ch1 81 23 ) ) -RRB- cord-024076-q9fw7ch1 81 24 as as IN cord-024076-q9fw7ch1 81 25 a a DT cord-024076-q9fw7ch1 81 26 SARS SARS NNP cord-024076-q9fw7ch1 81 27 - - HYPH cord-024076-q9fw7ch1 81 28 CoV-2 CoV-2 NNP cord-024076-q9fw7ch1 81 29 receptor receptor NN cord-024076-q9fw7ch1 81 30 : : : cord-024076-q9fw7ch1 81 31 molecular molecular JJ cord-024076-q9fw7ch1 81 32 mechanisms mechanism NNS cord-024076-q9fw7ch1 81 33 and and CC cord-024076-q9fw7ch1 81 34 potential potential JJ cord-024076-q9fw7ch1 81 35 therapeutic therapeutic JJ cord-024076-q9fw7ch1 81 36 target target NN