id	sid	tid	token	lemma	pos
cord-017585-0llgr357	1	1	key	key	JJ
cord-017585-0llgr357	1	2	:	:	:
cord-017585-0llgr357	1	3	cord-017585	cord-017585	NNP
cord-017585-0llgr357	1	4	-	-	HYPH
cord-017585-0llgr357	1	5	0llgr357	0llgr357	CD
cord-017585-0llgr357	1	6	authors	author	NNS
cord-017585-0llgr357	1	7	:	:	:
cord-017585-0llgr357	1	8	Chappell	Chappell	NNP
cord-017585-0llgr357	1	9	,	,	,
cord-017585-0llgr357	1	10	Mark	Mark	NNP
cord-017585-0llgr357	1	11	C.	C.	NNP
cord-017585-0llgr357	1	12	title	title	NN
cord-017585-0llgr357	1	13	:	:	:
cord-017585-0llgr357	1	14	Role	role	NN
cord-017585-0llgr357	1	15	of	of	IN
cord-017585-0llgr357	1	16	ACE	ACE	NNP
cord-017585-0llgr357	1	17	,	,	,
cord-017585-0llgr357	1	18	ACE2	ACE2	NNP
cord-017585-0llgr357	1	19	and	and	CC
cord-017585-0llgr357	1	20	Neprilysin	Neprilysin	NNP
cord-017585-0llgr357	1	21	in	in	IN
cord-017585-0llgr357	1	22	the	the	DT
cord-017585-0llgr357	1	23	Kidney	kidney	NN
cord-017585-0llgr357	1	24	date	date	NN
cord-017585-0llgr357	1	25	:	:	:
cord-017585-0llgr357	1	26	2007	2007	CD
cord-017585-0llgr357	1	27	journal	journal	NN
cord-017585-0llgr357	1	28	:	:	:
cord-017585-0llgr357	1	29	Frontiers	Frontiers	NNP
cord-017585-0llgr357	1	30	in	in	IN
cord-017585-0llgr357	1	31	Research	Research	NNP
cord-017585-0llgr357	1	32	of	of	IN
cord-017585-0llgr357	1	33	the	the	DT
cord-017585-0llgr357	1	34	Renin	Renin	NNP
cord-017585-0llgr357	1	35	-	-	HYPH
cord-017585-0llgr357	1	36	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	1	37	System	System	NNP
cord-017585-0llgr357	1	38	on	on	IN
cord-017585-0llgr357	1	39	Human	Human	NNP
cord-017585-0llgr357	1	40	Disease	Disease	NNP
cord-017585-0llgr357	1	41	DOI	DOI	NNP
cord-017585-0llgr357	1	42	:	:	:
cord-017585-0llgr357	1	43	10.1007/978	10.1007/978	CD
cord-017585-0llgr357	1	44	-	-	HYPH
cord-017585-0llgr357	1	45	1	1	CD
cord-017585-0llgr357	1	46	-	-	HYPH
cord-017585-0llgr357	1	47	4020	4020	CD
cord-017585-0llgr357	1	48	-	-	HYPH
cord-017585-0llgr357	1	49	6372	6372	CD
cord-017585-0llgr357	1	50	-	-	HYPH
cord-017585-0llgr357	1	51	5_1	5_1	CD
cord-017585-0llgr357	1	52	sha	sha	NN
cord-017585-0llgr357	1	53	:	:	:
cord-017585-0llgr357	1	54	cda18d4382416b0f821ddc5e3087bc2ea1b12fc0	cda18d4382416b0f821ddc5e3087bc2ea1b12fc0	NNP
cord-017585-0llgr357	1	55	doc_id	doc_id	CD
cord-017585-0llgr357	1	56	:	:	:
cord-017585-0llgr357	1	57	17585	17585	CD
cord-017585-0llgr357	1	58	cord_uid	cord_uid	NNS
cord-017585-0llgr357	1	59	:	:	:
cord-017585-0llgr357	1	60	0llgr357	0llgr357	ADD
cord-017585-0llgr357	2	1	nan	nan	NNP
cord-017585-0llgr357	3	1	From	from	IN
cord-017585-0llgr357	3	2	the	the	DT
cord-017585-0llgr357	3	3	initial	initial	JJ
cord-017585-0llgr357	3	4	description	description	NN
cord-017585-0llgr357	3	5	of	of	IN
cord-017585-0llgr357	3	6	renin	renin	NN
cord-017585-0llgr357	3	7	activity	activity	NN
cord-017585-0llgr357	3	8	over	over	IN
cord-017585-0llgr357	3	9	a	a	DT
cord-017585-0llgr357	3	10	century	century	NN
cord-017585-0llgr357	3	11	ago	ago	RB
cord-017585-0llgr357	3	12	,	,	,
cord-017585-0llgr357	3	13	ongoing	ongoing	JJ
cord-017585-0llgr357	3	14	study	study	NN
cord-017585-0llgr357	3	15	of	of	IN
cord-017585-0llgr357	3	16	the	the	DT
cord-017585-0llgr357	3	17	renin	renin	NN
cord-017585-0llgr357	3	18	-	-	HYPH
cord-017585-0llgr357	3	19	angiotensin	angiotensin	NN
cord-017585-0llgr357	3	20	-	-	HYPH
cord-017585-0llgr357	3	21	aldosterone	aldosterone	NN
cord-017585-0llgr357	3	22	system	system	NN
cord-017585-0llgr357	3	23	(	(	-LRB-
cord-017585-0llgr357	3	24	RAAS	RAAS	NNP
cord-017585-0llgr357	3	25	)	)	-RRB-
cord-017585-0llgr357	3	26	continues	continue	VBZ
cord-017585-0llgr357	3	27	to	to	TO
cord-017585-0llgr357	3	28	yield	yield	VB
cord-017585-0llgr357	3	29	novel	novel	JJ
cord-017585-0llgr357	3	30	findings	finding	NNS
cord-017585-0llgr357	3	31	that	that	WDT
cord-017585-0llgr357	3	32	redefine	redefine	VBP
cord-017585-0llgr357	3	33	the	the	DT
cord-017585-0llgr357	3	34	functional	functional	JJ
cord-017585-0llgr357	3	35	nature	nature	NN
cord-017585-0llgr357	3	36	of	of	IN
cord-017585-0llgr357	3	37	this	this	DT
cord-017585-0llgr357	3	38	system	system	NN
cord-017585-0llgr357	3	39	,	,	,
cord-017585-0llgr357	3	40	as	as	RB
cord-017585-0llgr357	3	41	well	well	RB
cord-017585-0llgr357	3	42	as	as	IN
cord-017585-0llgr357	3	43	reveal	reveal	VB
cord-017585-0llgr357	3	44	the	the	DT
cord-017585-0llgr357	3	45	complexity	complexity	NN
cord-017585-0llgr357	3	46	of	of	IN
cord-017585-0llgr357	3	47	the	the	DT
cord-017585-0llgr357	3	48	interplay	interplay	NN
cord-017585-0llgr357	3	49	among	among	IN
cord-017585-0llgr357	3	50	the	the	DT
cord-017585-0llgr357	3	51	various	various	JJ
cord-017585-0llgr357	3	52	RAAS	RAAS	NNP
cord-017585-0llgr357	3	53	components	component	NNS
cord-017585-0llgr357	3	54	.	.	.
cord-017585-0llgr357	4	1	Indeed	indeed	RB
cord-017585-0llgr357	4	2	,	,	,
cord-017585-0llgr357	4	3	the	the	DT
cord-017585-0llgr357	4	4	recent	recent	JJ
cord-017585-0llgr357	4	5	discoveries	discovery	NNS
cord-017585-0llgr357	4	6	of	of	IN
cord-017585-0llgr357	4	7	angiotensin	angiotensin	NN
cord-017585-0llgr357	4	8	converting	convert	VBG
cord-017585-0llgr357	4	9	enzyme	enzyme	NN
cord-017585-0llgr357	4	10	2	2	CD
cord-017585-0llgr357	4	11	(	(	-LRB-
cord-017585-0llgr357	4	12	ACE2	ACE2	NNP
cord-017585-0llgr357	4	13	)	)	-RRB-
cord-017585-0llgr357	5	1	Donoghue	Donoghue	NNP
cord-017585-0llgr357	5	2	et	et	NNP
cord-017585-0llgr357	5	3	al	al	NNP
cord-017585-0llgr357	5	4	2000	2000	CD
cord-017585-0llgr357	5	5	;	;	:
cord-017585-0llgr357	5	6	Tipnis	Tipnis	NNP
cord-017585-0llgr357	5	7	et	et	NNP
cord-017585-0llgr357	5	8	al	al	NNP
cord-017585-0llgr357	5	9	2000	2000	CD
cord-017585-0llgr357	5	10	)	)	-RRB-
cord-017585-0llgr357	5	11	;	;	:
cord-017585-0llgr357	5	12	the	the	DT
cord-017585-0llgr357	5	13	renin	renin	NN
cord-017585-0llgr357	5	14	receptor	receptor	NN
cord-017585-0llgr357	5	15	(	(	-LRB-
cord-017585-0llgr357	5	16	Nguyen	Nguyen	NNP
cord-017585-0llgr357	5	17	et	et	NNP
cord-017585-0llgr357	5	18	al	al	NNP
cord-017585-0llgr357	5	19	2002	2002	CD
cord-017585-0llgr357	5	20	)	)	-RRB-
cord-017585-0llgr357	5	21	and	and	CC
cord-017585-0llgr357	5	22	the	the	DT
cord-017585-0llgr357	5	23	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	5	24	-	-	SYM
cord-017585-0llgr357	5	25	7	7	CD
cord-017585-0llgr357	5	26	)	)	-RRB-
cord-017585-0llgr357	6	1	[	[	-LRB-
cord-017585-0llgr357	6	2	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	6	3	-	-	HYPH
cord-017585-0llgr357	6	4	7	7	CD
cord-017585-0llgr357	6	5	)	)	-RRB-
cord-017585-0llgr357	6	6	]	]	-RRB-
cord-017585-0llgr357	6	7	receptor	receptor	NN
cord-017585-0llgr357	6	8	(	(	-LRB-
cord-017585-0llgr357	6	9	Santos	Santos	NNP
cord-017585-0llgr357	6	10	et	et	NNP
cord-017585-0llgr357	6	11	al	al	NNP
cord-017585-0llgr357	6	12	2002	2002	CD
cord-017585-0llgr357	6	13	)	)	-RRB-
cord-017585-0llgr357	6	14	represent	represent	VBP
cord-017585-0llgr357	6	15	important	important	JJ
cord-017585-0llgr357	6	16	examples	example	NNS
cord-017585-0llgr357	6	17	of	of	IN
cord-017585-0llgr357	6	18	our	-PRON-	PRP$
cord-017585-0llgr357	6	19	evolving	evolve	VBG
cord-017585-0llgr357	6	20	concepts	concept	NNS
cord-017585-0llgr357	6	21	of	of	IN
cord-017585-0llgr357	6	22	the	the	DT
cord-017585-0llgr357	6	23	RAAS	raa	NNS
cord-017585-0llgr357	6	24	and	and	CC
cord-017585-0llgr357	6	25	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	6	26	regulation	regulation	NN
cord-017585-0llgr357	6	27	.	.	.
cord-017585-0llgr357	7	1	Coupled	couple	VBN
cord-017585-0llgr357	7	2	with	with	IN
cord-017585-0llgr357	7	3	the	the	DT
cord-017585-0llgr357	7	4	emerging	emerge	VBG
cord-017585-0llgr357	7	5	view	view	NN
cord-017585-0llgr357	7	6	that	that	IN
cord-017585-0llgr357	7	7	the	the	DT
cord-017585-0llgr357	7	8	RAAS	RAAS	NNP
cord-017585-0llgr357	7	9	is	be	VBZ
cord-017585-0llgr357	7	10	not	not	RB
cord-017585-0llgr357	7	11	defined	define	VBN
cord-017585-0llgr357	7	12	as	as	IN
cord-017585-0llgr357	7	13	simply	simply	RB
cord-017585-0llgr357	7	14	an	an	DT
cord-017585-0llgr357	7	15	endocrine	endocrine	JJ
cord-017585-0llgr357	7	16	system	system	NN
cord-017585-0llgr357	7	17	,	,	,
cord-017585-0llgr357	7	18	these	these	DT
cord-017585-0llgr357	7	19	local	local	JJ
cord-017585-0llgr357	7	20	or	or	CC
cord-017585-0llgr357	7	21	tissue	tissue	NN
cord-017585-0llgr357	7	22	systems	system	NNS
cord-017585-0llgr357	7	23	may	may	MD
cord-017585-0llgr357	7	24	exhibit	exhibit	VB
cord-017585-0llgr357	7	25	distinct	distinct	JJ
cord-017585-0llgr357	7	26	functional	functional	JJ
cord-017585-0llgr357	7	27	and	and	CC
cord-017585-0llgr357	7	28	processing	process	VBG
cord-017585-0llgr357	7	29	pathways	pathway	NNS
cord-017585-0llgr357	8	1	(	(	-LRB-
cord-017585-0llgr357	8	2	Chappell	Chappell	NNP
cord-017585-0llgr357	8	3	et	et	NNP
cord-017585-0llgr357	8	4	al	al	NNP
cord-017585-0llgr357	8	5	1989	1989	CD
cord-017585-0llgr357	8	6	;	;	:
cord-017585-0llgr357	8	7	Chappell	Chappell	NNP
cord-017585-0llgr357	8	8	et	et	NNP
cord-017585-0llgr357	8	9	al	al	NNP
cord-017585-0llgr357	8	10	2004	2004	CD
cord-017585-0llgr357	8	11	;	;	:
cord-017585-0llgr357	8	12	Paul	Paul	NNP
cord-017585-0llgr357	8	13	et	et	NNP
cord-017585-0llgr357	8	14	al	al	NNP
cord-017585-0llgr357	8	15	2006	2006	CD
cord-017585-0llgr357	8	16	)	)	-RRB-
cord-017585-0llgr357	8	17	.	.	.
cord-017585-0llgr357	9	1	The	the	DT
cord-017585-0llgr357	9	2	kidney	kidney	NN
cord-017585-0llgr357	9	3	is	be	VBZ
cord-017585-0llgr357	9	4	clearly	clearly	RB
cord-017585-0llgr357	9	5	an	an	DT
cord-017585-0llgr357	9	6	important	important	JJ
cord-017585-0llgr357	9	7	target	target	NN
cord-017585-0llgr357	9	8	organ	organ	NN
cord-017585-0llgr357	9	9	of	of	IN
cord-017585-0llgr357	9	10	the	the	DT
cord-017585-0llgr357	9	11	circulating	circulate	VBG
cord-017585-0llgr357	9	12	RAAS	RAAS	NNP
cord-017585-0llgr357	9	13	,	,	,
cord-017585-0llgr357	9	14	particularly	particularly	RB
cord-017585-0llgr357	9	15	the	the	DT
cord-017585-0llgr357	9	16	actions	action	NNS
cord-017585-0llgr357	9	17	of	of	IN
cord-017585-0llgr357	9	18	Ang	Ang	NNP
cord-017585-0llgr357	9	19	II	II	NNP
cord-017585-0llgr357	9	20	and	and	CC
cord-017585-0llgr357	9	21	aldosterone	aldosterone	NN
cord-017585-0llgr357	9	22	to	to	TO
cord-017585-0llgr357	9	23	promote	promote	VB
cord-017585-0llgr357	9	24	sodium	sodium	NN
cord-017585-0llgr357	9	25	and	and	CC
cord-017585-0llgr357	9	26	water	water	NN
cord-017585-0llgr357	9	27	reabsorption	reabsorption	NN
cord-017585-0llgr357	9	28	,	,	,
cord-017585-0llgr357	9	29	as	as	RB
cord-017585-0llgr357	9	30	well	well	RB
cord-017585-0llgr357	9	31	as	as	IN
cord-017585-0llgr357	9	32	their	-PRON-	PRP$
cord-017585-0llgr357	9	33	influence	influence	NN
cord-017585-0llgr357	9	34	on	on	IN
cord-017585-0llgr357	9	35	the	the	DT
cord-017585-0llgr357	9	36	progression	progression	NN
cord-017585-0llgr357	9	37	of	of	IN
cord-017585-0llgr357	9	38	tissue	tissue	NN
cord-017585-0llgr357	9	39	injury	injury	NN
cord-017585-0llgr357	9	40	and	and	CC
cord-017585-0llgr357	9	41	fibrosis	fibrosis	NN
cord-017585-0llgr357	9	42	(	(	-LRB-
cord-017585-0llgr357	9	43	Harris	Harris	NNP
cord-017585-0llgr357	9	44	1999	1999	CD
cord-017585-0llgr357	9	45	)	)	-RRB-
cord-017585-0llgr357	9	46	.	.	.
cord-017585-0llgr357	10	1	The	the	DT
cord-017585-0llgr357	10	2	kidney	kidney	NN
cord-017585-0llgr357	10	3	also	also	RB
cord-017585-0llgr357	10	4	exhibits	exhibit	VBZ
cord-017585-0llgr357	10	5	a	a	DT
cord-017585-0llgr357	10	6	local	local	JJ
cord-017585-0llgr357	10	7	RAAS	raa	NNS
cord-017585-0llgr357	10	8	that	that	WDT
cord-017585-0llgr357	10	9	expresses	express	VBZ
cord-017585-0llgr357	10	10	Ang	Ang	NNP
cord-017585-0llgr357	10	11	II	II	NNP
cord-017585-0llgr357	10	12	,	,	,
cord-017585-0llgr357	10	13	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	10	14	-	-	HYPH
cord-017585-0llgr357	10	15	7	7	CD
cord-017585-0llgr357	10	16	)	)	-RRB-
cord-017585-0llgr357	10	17	,	,	,
cord-017585-0llgr357	10	18	and	and	CC
cord-017585-0llgr357	10	19	multiple	multiple	JJ
cord-017585-0llgr357	10	20	Ang	Ang	NNP
cord-017585-0llgr357	10	21	receptor	receptor	NN
cord-017585-0llgr357	10	22	subtypes	subtype	NNS
cord-017585-0llgr357	10	23	that	that	WDT
cord-017585-0llgr357	10	24	mediate	mediate	VBP
cord-017585-0llgr357	10	25	the	the	DT
cord-017585-0llgr357	10	26	distinct	distinct	JJ
cord-017585-0llgr357	10	27	actions	action	NNS
cord-017585-0llgr357	10	28	of	of	IN
cord-017585-0llgr357	10	29	these	these	DT
cord-017585-0llgr357	10	30	two	two	CD
cord-017585-0llgr357	10	31	peptides	peptide	NNS
cord-017585-0llgr357	10	32	in	in	IN
cord-017585-0llgr357	10	33	both	both	CC
cord-017585-0llgr357	10	34	normal	normal	JJ
cord-017585-0llgr357	10	35	and	and	CC
cord-017585-0llgr357	10	36	pathophysiolgocial	pathophysiolgocial	JJ
cord-017585-0llgr357	10	37	conditions	condition	NNS
cord-017585-0llgr357	10	38	such	such	JJ
cord-017585-0llgr357	10	39	as	as	IN
cord-017585-0llgr357	10	40	hypertension	hypertension	NN
cord-017585-0llgr357	10	41	or	or	CC
cord-017585-0llgr357	10	42	diabetes	diabetes	NN
cord-017585-0llgr357	10	43	(	(	-LRB-
cord-017585-0llgr357	10	44	Burns	Burns	NNP
cord-017585-0llgr357	10	45	2000	2000	CD
cord-017585-0llgr357	10	46	;	;	:
cord-017585-0llgr357	10	47	Carey	Carey	NNP
cord-017585-0llgr357	10	48	&	&	CC
cord-017585-0llgr357	10	49	Siragy	Siragy	NNP
cord-017585-0llgr357	10	50	2003	2003	CD
cord-017585-0llgr357	10	51	;	;	:
cord-017585-0llgr357	10	52	Navar	Navar	NNP
cord-017585-0llgr357	10	53	et	et	NNP
cord-017585-0llgr357	10	54	al	al	NNP
cord-017585-0llgr357	10	55	2000	2000	CD
cord-017585-0llgr357	10	56	)	)	-RRB-
cord-017585-0llgr357	10	57	.	.	.
cord-017585-0llgr357	11	1	Figure	figure	NN
cord-017585-0llgr357	11	2	1	1	CD
cord-017585-0llgr357	11	3	illustrates	illustrate	VBZ
cord-017585-0llgr357	11	4	one	one	CD
cord-017585-0llgr357	11	5	current	current	JJ
cord-017585-0llgr357	11	6	view	view	NN
cord-017585-0llgr357	11	7	of	of	IN
cord-017585-0llgr357	11	8	the	the	DT
cord-017585-0llgr357	11	9	renal	renal	JJ
cord-017585-0llgr357	11	10	RAAS	RAAS	NNP
cord-017585-0llgr357	11	11	network	network	NN
cord-017585-0llgr357	11	12	that	that	WDT
cord-017585-0llgr357	11	13	emphasizes	emphasize	VBZ
cord-017585-0llgr357	11	14	the	the	DT
cord-017585-0llgr357	11	15	distinct	distinct	JJ
cord-017585-0llgr357	11	16	synthetic	synthetic	JJ
cord-017585-0llgr357	11	17	pathways	pathway	NNS
cord-017585-0llgr357	11	18	of	of	IN
cord-017585-0llgr357	11	19	Ang	Ang	NNP
cord-017585-0llgr357	11	20	II	II	NNP
cord-017585-0llgr357	11	21	and	and	CC
cord-017585-0llgr357	11	22	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	11	23	-	-	HYPH
cord-017585-0llgr357	11	24	7	7	CD
cord-017585-0llgr357	11	25	)	)	-RRB-
cord-017585-0llgr357	11	26	,	,	,
cord-017585-0llgr357	11	27	as	as	RB
cord-017585-0llgr357	11	28	well	well	RB
cord-017585-0llgr357	11	29	as	as	IN
cord-017585-0llgr357	11	30	functional	functional	JJ
cord-017585-0llgr357	11	31	actions	action	NNS
cord-017585-0llgr357	11	32	mediated	mediate	VBN
cord-017585-0llgr357	11	33	by	by	IN
cord-017585-0llgr357	11	34	the	the	DT
cord-017585-0llgr357	11	35	AT	AT	NNP
cord-017585-0llgr357	11	36	1	1	CD
cord-017585-0llgr357	11	37	,	,	,
cord-017585-0llgr357	11	38	AT	at	IN
cord-017585-0llgr357	11	39	2	2	CD
cord-017585-0llgr357	11	40	and	and	CC
cord-017585-0llgr357	11	41	AT	at	IN
cord-017585-0llgr357	11	42	1−7	1−7	NNP
cord-017585-0llgr357	11	43	receptors	receptor	NNS
cord-017585-0llgr357	11	44	.	.	.
cord-017585-0llgr357	12	1	Although	although	IN
cord-017585-0llgr357	12	2	the	the	DT
cord-017585-0llgr357	12	3	emergence	emergence	NN
cord-017585-0llgr357	12	4	of	of	IN
cord-017585-0llgr357	12	5	receptor	receptor	NN
cord-017585-0llgr357	12	6	subtypes	subtype	NNS
cord-017585-0llgr357	12	7	distinguishes	distinguish	VBZ
cord-017585-0llgr357	12	8	the	the	DT
cord-017585-0llgr357	12	9	distinct	distinct	JJ
cord-017585-0llgr357	12	10	signaling	signal	VBG
cord-017585-0llgr357	12	11	pathways	pathway	NNS
cord-017585-0llgr357	12	12	of	of	IN
cord-017585-0llgr357	12	13	Ang	Ang	NNP
cord-017585-0llgr357	12	14	II	II	NNP
cord-017585-0llgr357	12	15	and	and	CC
cord-017585-0llgr357	12	16	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	12	17	-	-	HYPH
cord-017585-0llgr357	12	18	7	7	CD
cord-017585-0llgr357	12	19	)	)	-RRB-
cord-017585-0llgr357	12	20	,	,	,
cord-017585-0llgr357	12	21	the	the	DT
cord-017585-0llgr357	12	22	post	post	JJ
cord-017585-0llgr357	12	23	-	-	JJ
cord-017585-0llgr357	12	24	renin	renin	JJ
cord-017585-0llgr357	12	25	enzymes	enzyme	NNS
cord-017585-0llgr357	12	26	that	that	WDT
cord-017585-0llgr357	12	27	form	form	VBP
cord-017585-0llgr357	12	28	and	and	CC
cord-017585-0llgr357	12	29	degrade	degrade	VB
cord-017585-0llgr357	12	30	these	these	DT
cord-017585-0llgr357	12	31	peptides	peptide	NNS
cord-017585-0llgr357	12	32	must	must	MD
cord-017585-0llgr357	12	33	be	be	VB
cord-017585-0llgr357	12	34	considered	consider	VBN
cord-017585-0llgr357	12	35	in	in	IN
cord-017585-0llgr357	12	36	lieu	lieu	NN
cord-017585-0llgr357	12	37	of	of	IN
cord-017585-0llgr357	12	38	the	the	DT
cord-017585-0llgr357	12	39	overall	overall	JJ
cord-017585-0llgr357	12	40	regulation	regulation	NN
cord-017585-0llgr357	12	41	of	of	IN
cord-017585-0llgr357	12	42	the	the	DT
cord-017585-0llgr357	12	43	functional	functional	JJ
cord-017585-0llgr357	12	44	RAAS	raa	NNS
cord-017585-0llgr357	12	45	within	within	IN
cord-017585-0llgr357	12	46	the	the	DT
cord-017585-0llgr357	12	47	kidney	kidney	NN
cord-017585-0llgr357	12	48	.	.	.
cord-017585-0llgr357	13	1	The	the	DT
cord-017585-0llgr357	13	2	inclusion	inclusion	NN
cord-017585-0llgr357	13	3	of	of	IN
cord-017585-0llgr357	13	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	13	5	-	-	HYPH
cord-017585-0llgr357	13	6	12	12	CD
cord-017585-0llgr357	13	7	)	)	-RRB-
cord-017585-0llgr357	13	8	as	as	IN
cord-017585-0llgr357	13	9	a	a	DT
cord-017585-0llgr357	13	10	potential	potential	JJ
cord-017585-0llgr357	13	11	intermediate	intermediate	NN
cord-017585-0llgr357	13	12	in	in	IN
cord-017585-0llgr357	13	13	Ang	Ang	NNP
cord-017585-0llgr357	13	14	II	II	NNP
cord-017585-0llgr357	13	15	formation	formation	NN
cord-017585-0llgr357	13	16	via	via	IN
cord-017585-0llgr357	13	17	a	a	DT
cord-017585-0llgr357	13	18	renin	renin	NN
cord-017585-0llgr357	13	19	-	-	HYPH
cord-017585-0llgr357	13	20	independent	independent	JJ
cord-017585-0llgr357	13	21	pathway	pathway	NN
cord-017585-0llgr357	13	22	reflects	reflect	VBZ
cord-017585-0llgr357	13	23	the	the	DT
cord-017585-0llgr357	13	24	recent	recent	JJ
cord-017585-0llgr357	13	25	1	1	CD
cord-017585-0llgr357	13	26	Figure	figure	NN
cord-017585-0llgr357	13	27	1	1	CD
cord-017585-0llgr357	13	28	.	.	.
cord-017585-0llgr357	14	1	Scheme	scheme	NN
cord-017585-0llgr357	14	2	that	that	WDT
cord-017585-0llgr357	14	3	depicts	depict	VBZ
cord-017585-0llgr357	14	4	the	the	DT
cord-017585-0llgr357	14	5	processing	processing	NN
cord-017585-0llgr357	14	6	pathways	pathway	NNS
cord-017585-0llgr357	14	7	involved	involve	VBN
cord-017585-0llgr357	14	8	in	in	IN
cord-017585-0llgr357	14	9	the	the	DT
cord-017585-0llgr357	14	10	formation	formation	NN
cord-017585-0llgr357	14	11	and	and	CC
cord-017585-0llgr357	14	12	degradation	degradation	NN
cord-017585-0llgr357	14	13	of	of	IN
cord-017585-0llgr357	14	14	angiotensin	angiotensin	NN
cord-017585-0llgr357	14	15	II	II	NNP
cord-017585-0llgr357	14	16	(	(	-LRB-
cord-017585-0llgr357	14	17	Ang	Ang	NNP
cord-017585-0llgr357	14	18	II	II	NNP
cord-017585-0llgr357	14	19	)	)	-RRB-
cord-017585-0llgr357	14	20	and	and	CC
cord-017585-0llgr357	14	21	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	14	22	-	-	HYPH
cord-017585-0llgr357	14	23	7	7	CD
cord-017585-0llgr357	14	24	)	)	-RRB-
cord-017585-0llgr357	14	25	within	within	IN
cord-017585-0llgr357	14	26	the	the	DT
cord-017585-0llgr357	14	27	kidney	kidney	NN
cord-017585-0llgr357	14	28	.	.	.
cord-017585-0llgr357	15	1	Ang	Ang	NNP
cord-017585-0llgr357	15	2	II	II	NNP
cord-017585-0llgr357	15	3	binds	bind	VBZ
cord-017585-0llgr357	15	4	to	to	IN
cord-017585-0llgr357	15	5	either	either	CC
cord-017585-0llgr357	15	6	AT	at	IN
cord-017585-0llgr357	15	7	1	1	CD
cord-017585-0llgr357	15	8	or	or	CC
cord-017585-0llgr357	15	9	AT	at	IN
cord-017585-0llgr357	15	10	2	2	CD
cord-017585-0llgr357	15	11	receptor	receptor	NN
cord-017585-0llgr357	15	12	(	(	-LRB-
cord-017585-0llgr357	15	13	R	r	NN
cord-017585-0llgr357	15	14	)	)	-RRB-
cord-017585-0llgr357	15	15	subtypes	subtype	NNS
cord-017585-0llgr357	15	16	,	,	,
cord-017585-0llgr357	15	17	while	while	IN
cord-017585-0llgr357	15	18	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	15	19	-	-	HYPH
cord-017585-0llgr357	15	20	7	7	NNP
cord-017585-0llgr357	15	21	)	)	-RRB-
cord-017585-0llgr357	15	22	recognizes	recognize	VBZ
cord-017585-0llgr357	15	23	an	an	DT
cord-017585-0llgr357	15	24	AT	AT	NNP
cord-017585-0llgr357	15	25	1−7	1−7	NNP
cord-017585-0llgr357	15	26	R.	R.	NNP
cord-017585-0llgr357	15	27	ACE	ACE	NNP
cord-017585-0llgr357	15	28	,	,	,
cord-017585-0llgr357	15	29	angiotensin	angiotensin	NN
cord-017585-0llgr357	15	30	converting	convert	VBG
cord-017585-0llgr357	15	31	enzyme	enzyme	NN
cord-017585-0llgr357	15	32	;	;	:
cord-017585-0llgr357	15	33	EPs	ep	NNS
cord-017585-0llgr357	15	34	,	,	,
cord-017585-0llgr357	15	35	endopeptidases	endopeptidase	NNS
cord-017585-0llgr357	15	36	;	;	:
cord-017585-0llgr357	15	37	NEP	NEP	NNP
cord-017585-0llgr357	15	38	,	,	,
cord-017585-0llgr357	15	39	neprilysin	neprilysin	NNP
cord-017585-0llgr357	15	40	demonstration	demonstration	NN
cord-017585-0llgr357	15	41	of	of	IN
cord-017585-0llgr357	15	42	endogenous	endogenous	JJ
cord-017585-0llgr357	15	43	levels	level	NNS
cord-017585-0llgr357	15	44	of	of	IN
cord-017585-0llgr357	15	45	the	the	DT
cord-017585-0llgr357	15	46	peptide	peptide	NN
cord-017585-0llgr357	15	47	in	in	IN
cord-017585-0llgr357	15	48	the	the	DT
cord-017585-0llgr357	15	49	kidney	kidney	NN
cord-017585-0llgr357	15	50	,	,	,
cord-017585-0llgr357	15	51	circulation	circulation	NN
cord-017585-0llgr357	15	52	and	and	CC
cord-017585-0llgr357	15	53	other	other	JJ
cord-017585-0llgr357	15	54	tissues	tissue	NNS
cord-017585-0llgr357	15	55	(	(	-LRB-
cord-017585-0llgr357	15	56	Nagata	Nagata	NNP
cord-017585-0llgr357	15	57	et	et	NNP
cord-017585-0llgr357	15	58	al	al	NNP
cord-017585-0llgr357	15	59	2006	2006	CD
cord-017585-0llgr357	15	60	)	)	-RRB-
cord-017585-0llgr357	15	61	.	.	.
cord-017585-0llgr357	16	1	In	in	IN
cord-017585-0llgr357	16	2	this	this	DT
cord-017585-0llgr357	16	3	chapter	chapter	NN
cord-017585-0llgr357	16	4	,	,	,
cord-017585-0llgr357	16	5	the	the	DT
cord-017585-0llgr357	16	6	roles	role	NNS
cord-017585-0llgr357	16	7	of	of	IN
cord-017585-0llgr357	16	8	ACE2	ACE2	NNP
cord-017585-0llgr357	16	9	,	,	,
cord-017585-0llgr357	16	10	ACE	ACE	NNP
cord-017585-0llgr357	16	11	and	and	CC
cord-017585-0llgr357	16	12	the	the	DT
cord-017585-0llgr357	16	13	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	16	14	neprilysin	neprilysin	NN
cord-017585-0llgr357	16	15	in	in	IN
cord-017585-0llgr357	16	16	the	the	DT
cord-017585-0llgr357	16	17	functional	functional	JJ
cord-017585-0llgr357	16	18	expression	expression	NN
cord-017585-0llgr357	16	19	of	of	IN
cord-017585-0llgr357	16	20	the	the	DT
cord-017585-0llgr357	16	21	intrarenal	intrarenal	JJ
cord-017585-0llgr357	16	22	hormones	hormone	NNS
cord-017585-0llgr357	16	23	of	of	IN
cord-017585-0llgr357	16	24	the	the	DT
cord-017585-0llgr357	16	25	RAAS	raa	NNS
cord-017585-0llgr357	16	26	are	be	VBP
cord-017585-0llgr357	16	27	reviewed	review	VBN
cord-017585-0llgr357	16	28	.	.	.
cord-017585-0llgr357	17	1	ACE	ACE	NNP
cord-017585-0llgr357	17	2	may	may	MD
cord-017585-0llgr357	17	3	be	be	VB
cord-017585-0llgr357	17	4	considered	consider	VBN
cord-017585-0llgr357	17	5	the	the	DT
cord-017585-0llgr357	17	6	activation	activation	NN
cord-017585-0llgr357	17	7	step	step	NN
cord-017585-0llgr357	17	8	in	in	IN
cord-017585-0llgr357	17	9	the	the	DT
cord-017585-0llgr357	17	10	catalytic	catalytic	JJ
cord-017585-0llgr357	17	11	cascade	cascade	NN
cord-017585-0llgr357	17	12	for	for	IN
cord-017585-0llgr357	17	13	the	the	DT
cord-017585-0llgr357	17	14	formation	formation	NN
cord-017585-0llgr357	17	15	of	of	IN
cord-017585-0llgr357	17	16	Ang	Ang	NNP
cord-017585-0llgr357	17	17	II	II	NNP
cord-017585-0llgr357	17	18	from	from	IN
cord-017585-0llgr357	17	19	Ang	Ang	NNP
cord-017585-0llgr357	17	20	I	I	NNP
cord-017585-0llgr357	17	21	(	(	-LRB-
cord-017585-0llgr357	17	22	Fig	Fig	NNP
cord-017585-0llgr357	17	23	.	.	.
cord-017585-0llgr357	17	24	1	1	CD
cord-017585-0llgr357	17	25	)	)	-RRB-
cord-017585-0llgr357	17	26	.	.	.
cord-017585-0llgr357	18	1	Although	although	IN
cord-017585-0llgr357	18	2	evidence	evidence	NN
cord-017585-0llgr357	18	3	of	of	IN
cord-017585-0llgr357	18	4	non	non	JJ
cord-017585-0llgr357	18	5	-	-	JJ
cord-017585-0llgr357	18	6	ACE	ace	JJ
cord-017585-0llgr357	18	7	pathways	pathway	NNS
cord-017585-0llgr357	18	8	for	for	IN
cord-017585-0llgr357	18	9	biosynthesis	biosynthesis	NN
cord-017585-0llgr357	18	10	of	of	IN
cord-017585-0llgr357	18	11	Ang	Ang	NNP
cord-017585-0llgr357	18	12	II	II	NNP
cord-017585-0llgr357	18	13	is	be	VBZ
cord-017585-0llgr357	18	14	evident	evident	JJ
cord-017585-0llgr357	18	15	(	(	-LRB-
cord-017585-0llgr357	18	16	Sadjadi	Sadjadi	NNP
cord-017585-0llgr357	18	17	et	et	NNP
cord-017585-0llgr357	18	18	al	al	NNP
cord-017585-0llgr357	18	19	2005a	2005a	CD
cord-017585-0llgr357	18	20	;	;	:
cord-017585-0llgr357	18	21	Tokuyama	Tokuyama	NNP
cord-017585-0llgr357	18	22	et	et	NNP
cord-017585-0llgr357	18	23	al	al	NNP
cord-017585-0llgr357	18	24	2002	2002	CD
cord-017585-0llgr357	18	25	)	)	-RRB-
cord-017585-0llgr357	18	26	,	,	,
cord-017585-0llgr357	18	27	ACE	ACE	NNP
cord-017585-0llgr357	18	28	likely	likely	RB
cord-017585-0llgr357	18	29	represents	represent	VBZ
cord-017585-0llgr357	18	30	the	the	DT
cord-017585-0llgr357	18	31	major	major	JJ
cord-017585-0llgr357	18	32	,	,	,
cord-017585-0llgr357	18	33	if	if	IN
cord-017585-0llgr357	18	34	not	not	RB
cord-017585-0llgr357	18	35	sole	sole	JJ
cord-017585-0llgr357	18	36	enzyme	enzyme	NN
cord-017585-0llgr357	18	37	responsible	responsible	JJ
cord-017585-0llgr357	18	38	for	for	IN
cord-017585-0llgr357	18	39	Ang	Ang	NNP
cord-017585-0llgr357	18	40	II	II	NNP
cord-017585-0llgr357	18	41	formation	formation	NN
cord-017585-0llgr357	18	42	under	under	IN
cord-017585-0llgr357	18	43	normal	normal	JJ
cord-017585-0llgr357	18	44	physiological	physiological	JJ
cord-017585-0llgr357	18	45	conditions	condition	NNS
cord-017585-0llgr357	18	46	in	in	IN
cord-017585-0llgr357	18	47	humans	human	NNS
cord-017585-0llgr357	18	48	and	and	CC
cord-017585-0llgr357	18	49	other	other	JJ
cord-017585-0llgr357	18	50	species	specie	NNS
cord-017585-0llgr357	18	51	.	.	.
cord-017585-0llgr357	19	1	This	this	DT
cord-017585-0llgr357	19	2	is	be	VBZ
cord-017585-0llgr357	19	3	not	not	RB
cord-017585-0llgr357	19	4	to	to	TO
cord-017585-0llgr357	19	5	imply	imply	VB
cord-017585-0llgr357	19	6	that	that	IN
cord-017585-0llgr357	19	7	ACE	ACE	NNP
cord-017585-0llgr357	19	8	has	have	VBZ
cord-017585-0llgr357	19	9	no	no	DT
cord-017585-0llgr357	19	10	other	other	JJ
cord-017585-0llgr357	19	11	substrates	substrate	NNS
cord-017585-0llgr357	19	12	than	than	IN
cord-017585-0llgr357	19	13	Ang	Ang	NNP
cord-017585-0llgr357	19	14	I	-PRON-	PRP
cord-017585-0llgr357	19	15	(	(	-LRB-
cord-017585-0llgr357	19	16	see	see	VB
cord-017585-0llgr357	19	17	below	below	RB
cord-017585-0llgr357	19	18	)	)	-RRB-
cord-017585-0llgr357	19	19	,	,	,
cord-017585-0llgr357	19	20	but	but	CC
cord-017585-0llgr357	19	21	that	that	IN
cord-017585-0llgr357	19	22	a	a	DT
cord-017585-0llgr357	19	23	primary	primary	JJ
cord-017585-0llgr357	19	24	role	role	NN
cord-017585-0llgr357	19	25	for	for	IN
cord-017585-0llgr357	19	26	ACE	ACE	NNP
cord-017585-0llgr357	19	27	is	be	VBZ
cord-017585-0llgr357	19	28	the	the	DT
cord-017585-0llgr357	19	29	generation	generation	NN
cord-017585-0llgr357	19	30	of	of	IN
cord-017585-0llgr357	19	31	Ang	Ang	NNP
cord-017585-0llgr357	19	32	II	II	NNP
cord-017585-0llgr357	19	33	.	.	.
cord-017585-0llgr357	20	1	Indeed	indeed	RB
cord-017585-0llgr357	20	2	,	,	,
cord-017585-0llgr357	20	3	the	the	DT
cord-017585-0llgr357	20	4	identification	identification	NN
cord-017585-0llgr357	20	5	of	of	IN
cord-017585-0llgr357	20	6	ACE	ace	NN
cord-017585-0llgr357	20	7	and	and	CC
cord-017585-0llgr357	20	8	the	the	DT
cord-017585-0llgr357	20	9	characterization	characterization	NN
cord-017585-0llgr357	20	10	of	of	IN
cord-017585-0llgr357	20	11	the	the	DT
cord-017585-0llgr357	20	12	enzymatic	enzymatic	JJ
cord-017585-0llgr357	20	13	properties	property	NNS
cord-017585-0llgr357	20	14	must	must	MD
cord-017585-0llgr357	20	15	be	be	VB
cord-017585-0llgr357	20	16	considered	consider	VBN
cord-017585-0llgr357	20	17	a	a	DT
cord-017585-0llgr357	20	18	pivotal	pivotal	JJ
cord-017585-0llgr357	20	19	achievement	achievement	NN
cord-017585-0llgr357	20	20	in	in	IN
cord-017585-0llgr357	20	21	our	-PRON-	PRP$
cord-017585-0llgr357	20	22	understanding	understanding	NN
cord-017585-0llgr357	20	23	of	of	IN
cord-017585-0llgr357	20	24	the	the	DT
cord-017585-0llgr357	20	25	RAAS	raa	NNS
cord-017585-0llgr357	20	26	and	and	CC
cord-017585-0llgr357	20	27	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	20	28	disease	disease	NN
cord-017585-0llgr357	20	29	,	,	,
cord-017585-0llgr357	20	30	as	as	RB
cord-017585-0llgr357	20	31	well	well	RB
cord-017585-0llgr357	20	32	as	as	IN
cord-017585-0llgr357	20	33	leading	lead	VBG
cord-017585-0llgr357	20	34	to	to	IN
cord-017585-0llgr357	20	35	the	the	DT
cord-017585-0llgr357	20	36	successful	successful	JJ
cord-017585-0llgr357	20	37	development	development	NN
cord-017585-0llgr357	20	38	of	of	IN
cord-017585-0llgr357	20	39	ACE	ACE	NNP
cord-017585-0llgr357	20	40	inhibitors	inhibitor	NNS
cord-017585-0llgr357	20	41	in	in	IN
cord-017585-0llgr357	20	42	the	the	DT
cord-017585-0llgr357	20	43	treatment	treatment	NN
cord-017585-0llgr357	20	44	for	for	IN
cord-017585-0llgr357	20	45	hypertension	hypertension	NN
cord-017585-0llgr357	20	46	and	and	CC
cord-017585-0llgr357	20	47	renal	renal	JJ
cord-017585-0llgr357	20	48	disease	disease	NN
cord-017585-0llgr357	20	49	.	.	.
cord-017585-0llgr357	21	1	ACE	ACE	NNP
cord-017585-0llgr357	21	2	is	be	VBZ
cord-017585-0llgr357	21	3	a	a	DT
cord-017585-0llgr357	21	4	metallopeptidase	metallopeptidase	NN
cord-017585-0llgr357	21	5	composed	compose	VBN
cord-017585-0llgr357	21	6	of	of	IN
cord-017585-0llgr357	21	7	a	a	DT
cord-017585-0llgr357	21	8	single	single	JJ
cord-017585-0llgr357	21	9	monomeric	monomeric	JJ
cord-017585-0llgr357	21	10	protein	protein	NN
cord-017585-0llgr357	21	11	.	.	.
cord-017585-0llgr357	22	1	Somatic	somatic	JJ
cord-017585-0llgr357	22	2	ACE	ACE	NNP
cord-017585-0llgr357	22	3	contains	contain	VBZ
cord-017585-0llgr357	22	4	two	two	CD
cord-017585-0llgr357	22	5	catalytic	catalytic	JJ
cord-017585-0llgr357	22	6	regions	region	NNS
cord-017585-0llgr357	22	7	designated	designate	VBN
cord-017585-0llgr357	22	8	as	as	IN
cord-017585-0llgr357	22	9	the	the	DT
cord-017585-0llgr357	22	10	amino	amino	NNS
cord-017585-0llgr357	22	11	(	(	-LRB-
cord-017585-0llgr357	22	12	N	N	NNP
cord-017585-0llgr357	22	13	)	)	-RRB-
cord-017585-0llgr357	22	14	and	and	CC
cord-017585-0llgr357	22	15	carboxy	carboxy	NNP
cord-017585-0llgr357	22	16	(	(	-LRB-
cord-017585-0llgr357	22	17	C	C	NNP
cord-017585-0llgr357	22	18	)	)	-RRB-
cord-017585-0llgr357	22	19	domains	domain	NNS
cord-017585-0llgr357	22	20	.	.	.
cord-017585-0llgr357	23	1	Selective	selective	JJ
cord-017585-0llgr357	23	2	inhibitors	inhibitor	NNS
cord-017585-0llgr357	23	3	against	against	IN
cord-017585-0llgr357	23	4	both	both	CC
cord-017585-0llgr357	23	5	catalytic	catalytic	JJ
cord-017585-0llgr357	23	6	domains	domain	NNS
cord-017585-0llgr357	23	7	of	of	IN
cord-017585-0llgr357	23	8	somatic	somatic	JJ
cord-017585-0llgr357	23	9	ACE	ace	NN
cord-017585-0llgr357	23	10	are	be	VBP
cord-017585-0llgr357	23	11	now	now	RB
cord-017585-0llgr357	23	12	available	available	JJ
cord-017585-0llgr357	23	13	,	,	,
cord-017585-0llgr357	23	14	however	however	RB
cord-017585-0llgr357	23	15	,	,	,
cord-017585-0llgr357	23	16	the	the	DT
cord-017585-0llgr357	23	17	functional	functional	JJ
cord-017585-0llgr357	23	18	significance	significance	NN
cord-017585-0llgr357	23	19	of	of	IN
cord-017585-0llgr357	23	20	the	the	DT
cord-017585-0llgr357	23	21	two	two	CD
cord-017585-0llgr357	23	22	domains	domain	NNS
cord-017585-0llgr357	23	23	is	be	VBZ
cord-017585-0llgr357	23	24	presently	presently	RB
cord-017585-0llgr357	23	25	unknown	unknown	JJ
cord-017585-0llgr357	24	1	(	(	-LRB-
cord-017585-0llgr357	24	2	Dive	dive	VB
cord-017585-0llgr357	24	3	et	et	FW
cord-017585-0llgr357	24	4	al	al	NNP
cord-017585-0llgr357	24	5	1999	1999	CD
cord-017585-0llgr357	24	6	;	;	:
cord-017585-0llgr357	24	7	Georgiadis	Georgiadis	NNP
cord-017585-0llgr357	24	8	et	et	NNP
cord-017585-0llgr357	24	9	al	al	NNP
cord-017585-0llgr357	24	10	2003	2003	CD
cord-017585-0llgr357	24	11	)	)	-RRB-
cord-017585-0llgr357	24	12	.	.	.
cord-017585-0llgr357	25	1	The	the	DT
cord-017585-0llgr357	25	2	enzyme	enzyme	NN
cord-017585-0llgr357	25	3	cleaves	cleave	VBZ
cord-017585-0llgr357	25	4	two	two	CD
cord-017585-0llgr357	25	5	residues	residue	NNS
cord-017585-0llgr357	25	6	from	from	IN
cord-017585-0llgr357	25	7	the	the	DT
cord-017585-0llgr357	25	8	carboxy	carboxy	JJ
cord-017585-0llgr357	25	9	end	end	NN
cord-017585-0llgr357	25	10	of	of	IN
cord-017585-0llgr357	25	11	various	various	JJ
cord-017585-0llgr357	25	12	peptides	peptide	NNS
cord-017585-0llgr357	25	13	and	and	CC
cord-017585-0llgr357	25	14	,	,	,
cord-017585-0llgr357	25	15	hence	hence	RB
cord-017585-0llgr357	25	16	,	,	,
cord-017585-0llgr357	25	17	its	-PRON-	PRP$
cord-017585-0llgr357	25	18	description	description	NN
cord-017585-0llgr357	25	19	as	as	IN
cord-017585-0llgr357	25	20	a	a	DT
cord-017585-0llgr357	25	21	dipeptidyl	dipeptidyl	JJ
cord-017585-0llgr357	25	22	-	-	HYPH
cord-017585-0llgr357	25	23	carboxypepitdase	carboxypepitdase	NN
cord-017585-0llgr357	25	24	.	.	.
cord-017585-0llgr357	26	1	Within	within	IN
cord-017585-0llgr357	26	2	the	the	DT
cord-017585-0llgr357	26	3	kidney	kidney	NN
cord-017585-0llgr357	26	4	,	,	,
cord-017585-0llgr357	26	5	somatic	somatic	JJ
cord-017585-0llgr357	26	6	ACE	ACE	NNP
cord-017585-0llgr357	26	7	is	be	VBZ
cord-017585-0llgr357	26	8	primarily	primarily	RB
cord-017585-0llgr357	26	9	a	a	DT
cord-017585-0llgr357	26	10	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-017585-0llgr357	26	11	-	-	HYPH
cord-017585-0llgr357	26	12	anchored	anchor	VBN
cord-017585-0llgr357	26	13	membrane	membrane	NN
cord-017585-0llgr357	26	14	protein	protein	NN
cord-017585-0llgr357	26	15	and	and	CC
cord-017585-0llgr357	26	16	the	the	DT
cord-017585-0llgr357	26	17	majority	majority	NN
cord-017585-0llgr357	26	18	of	of	IN
cord-017585-0llgr357	26	19	the	the	DT
cord-017585-0llgr357	26	20	enzyme	enzyme	NN
cord-017585-0llgr357	26	21	including	include	VBG
cord-017585-0llgr357	26	22	both	both	CC
cord-017585-0llgr357	26	23	catalytic	catalytic	JJ
cord-017585-0llgr357	26	24	regions	region	NNS
cord-017585-0llgr357	26	25	faces	face	VBZ
cord-017585-0llgr357	26	26	the	the	DT
cord-017585-0llgr357	26	27	extracellular	extracellular	JJ
cord-017585-0llgr357	26	28	space	space	NN
cord-017585-0llgr357	26	29	.	.	.
cord-017585-0llgr357	27	1	ACE	ACE	NNP
cord-017585-0llgr357	27	2	is	be	VBZ
cord-017585-0llgr357	27	3	localized	localize	VBN
cord-017585-0llgr357	27	4	throughout	throughout	IN
cord-017585-0llgr357	27	5	the	the	DT
cord-017585-0llgr357	27	6	kidney	kidney	NN
cord-017585-0llgr357	27	7	with	with	IN
cord-017585-0llgr357	27	8	high	high	JJ
cord-017585-0llgr357	27	9	concentrations	concentration	NNS
cord-017585-0llgr357	27	10	in	in	IN
cord-017585-0llgr357	27	11	vascular	vascular	JJ
cord-017585-0llgr357	27	12	endothelial	endothelial	JJ
cord-017585-0llgr357	27	13	cells	cell	NNS
cord-017585-0llgr357	27	14	,	,	,
cord-017585-0llgr357	27	15	proximal	proximal	JJ
cord-017585-0llgr357	27	16	tubules	tubule	NNS
cord-017585-0llgr357	27	17	and	and	CC
cord-017585-0llgr357	27	18	interstitial	interstitial	JJ
cord-017585-0llgr357	27	19	cells	cell	NNS
cord-017585-0llgr357	27	20	.	.	.
cord-017585-0llgr357	28	1	ACE	ACE	NNP
cord-017585-0llgr357	28	2	is	be	VBZ
cord-017585-0llgr357	28	3	also	also	RB
cord-017585-0llgr357	28	4	released	release	VBN
cord-017585-0llgr357	28	5	from	from	IN
cord-017585-0llgr357	28	6	the	the	DT
cord-017585-0llgr357	28	7	apical	apical	JJ
cord-017585-0llgr357	28	8	surface	surface	NN
cord-017585-0llgr357	28	9	of	of	IN
cord-017585-0llgr357	28	10	epithelial	epithelial	JJ
cord-017585-0llgr357	28	11	cells	cell	NNS
cord-017585-0llgr357	28	12	into	into	IN
cord-017585-0llgr357	28	13	the	the	DT
cord-017585-0llgr357	28	14	proximal	proximal	JJ
cord-017585-0llgr357	28	15	tubular	tubular	JJ
cord-017585-0llgr357	28	16	fluid	fluid	NN
cord-017585-0llgr357	28	17	and	and	CC
cord-017585-0llgr357	28	18	likely	likely	RB
cord-017585-0llgr357	28	19	contributes	contribute	VBZ
cord-017585-0llgr357	28	20	to	to	IN
cord-017585-0llgr357	28	21	the	the	DT
cord-017585-0llgr357	28	22	urinary	urinary	JJ
cord-017585-0llgr357	28	23	levels	level	NNS
cord-017585-0llgr357	28	24	of	of	IN
cord-017585-0llgr357	28	25	the	the	DT
cord-017585-0llgr357	28	26	enzyme	enzyme	NN
cord-017585-0llgr357	29	1	(	(	-LRB-
cord-017585-0llgr357	29	2	Hattori	Hattori	NNP
cord-017585-0llgr357	29	3	et	et	NNP
cord-017585-0llgr357	29	4	al	al	NNP
cord-017585-0llgr357	29	5	2000	2000	CD
cord-017585-0llgr357	29	6	)	)	-RRB-
cord-017585-0llgr357	29	7	.	.	.
cord-017585-0llgr357	30	1	Indeed	indeed	RB
cord-017585-0llgr357	30	2	,	,	,
cord-017585-0llgr357	30	3	the	the	DT
cord-017585-0llgr357	30	4	tubular	tubular	JJ
cord-017585-0llgr357	30	5	fluid	fluid	NN
cord-017585-0llgr357	30	6	should	should	MD
cord-017585-0llgr357	30	7	be	be	VB
cord-017585-0llgr357	30	8	considered	consider	VBN
cord-017585-0llgr357	30	9	a	a	DT
cord-017585-0llgr357	30	10	distinct	distinct	JJ
cord-017585-0llgr357	30	11	intrarenal	intrarenal	JJ
cord-017585-0llgr357	30	12	compartment	compartment	NN
cord-017585-0llgr357	30	13	that	that	WDT
cord-017585-0llgr357	30	14	contains	contain	VBZ
cord-017585-0llgr357	30	15	RAAS	RAAS	NNP
cord-017585-0llgr357	30	16	processing	processing	NN
cord-017585-0llgr357	30	17	enzymes	enzyme	NNS
cord-017585-0llgr357	30	18	and	and	CC
cord-017585-0llgr357	30	19	the	the	DT
cord-017585-0llgr357	30	20	peptide	peptide	NN
cord-017585-0llgr357	30	21	products	product	NNS
cord-017585-0llgr357	30	22	may	may	MD
cord-017585-0llgr357	30	23	interact	interact	VB
cord-017585-0llgr357	30	24	with	with	IN
cord-017585-0llgr357	30	25	Ang	Ang	NNP
cord-017585-0llgr357	30	26	receptors	receptor	NNS
cord-017585-0llgr357	30	27	along	along	IN
cord-017585-0llgr357	30	28	the	the	DT
cord-017585-0llgr357	30	29	entire	entire	JJ
cord-017585-0llgr357	30	30	tubular	tubular	JJ
cord-017585-0llgr357	30	31	area	area	NN
cord-017585-0llgr357	30	32	of	of	IN
cord-017585-0llgr357	30	33	the	the	DT
cord-017585-0llgr357	30	34	kidney	kidney	NN
cord-017585-0llgr357	30	35	.	.	.
cord-017585-0llgr357	31	1	The	the	DT
cord-017585-0llgr357	31	2	release	release	NN
cord-017585-0llgr357	31	3	of	of	IN
cord-017585-0llgr357	31	4	ACE	ace	NN
cord-017585-0llgr357	31	5	from	from	IN
cord-017585-0llgr357	31	6	the	the	DT
cord-017585-0llgr357	31	7	cell	cell	NN
cord-017585-0llgr357	31	8	membrane	membrane	NN
cord-017585-0llgr357	31	9	is	be	VBZ
cord-017585-0llgr357	31	10	a	a	DT
cord-017585-0llgr357	31	11	specific	specific	JJ
cord-017585-0llgr357	31	12	process	process	NN
cord-017585-0llgr357	31	13	as	as	IN
cord-017585-0llgr357	31	14	releasing	release	VBG
cord-017585-0llgr357	31	15	enzymes	enzyme	NNS
cord-017585-0llgr357	31	16	or	or	CC
cord-017585-0llgr357	31	17	"	"	``
cord-017585-0llgr357	31	18	sheddases	sheddase	NNS
cord-017585-0llgr357	31	19	"	"	''
cord-017585-0llgr357	31	20	have	have	VBP
cord-017585-0llgr357	31	21	been	be	VBN
cord-017585-0llgr357	31	22	identified	identify	VBN
cord-017585-0llgr357	31	23	that	that	WDT
cord-017585-0llgr357	31	24	recognize	recognize	VBP
cord-017585-0llgr357	31	25	a	a	DT
cord-017585-0llgr357	31	26	unique	unique	JJ
cord-017585-0llgr357	31	27	motif	motif	NN
cord-017585-0llgr357	31	28	on	on	IN
cord-017585-0llgr357	31	29	the	the	DT
cord-017585-0llgr357	31	30	stalk	stalk	NN
cord-017585-0llgr357	31	31	region	region	NN
cord-017585-0llgr357	31	32	of	of	IN
cord-017585-0llgr357	31	33	the	the	DT
cord-017585-0llgr357	31	34	enzyme	enzyme	NN
cord-017585-0llgr357	32	1	(	(	-LRB-
cord-017585-0llgr357	32	2	Beldent	Beldent	NNP
cord-017585-0llgr357	32	3	et	et	NNP
cord-017585-0llgr357	32	4	al	al	NNP
cord-017585-0llgr357	32	5	1993	1993	CD
cord-017585-0llgr357	32	6	)	)	-RRB-
cord-017585-0llgr357	32	7	.	.	.
cord-017585-0llgr357	33	1	The	the	DT
cord-017585-0llgr357	33	2	conversion	conversion	NN
cord-017585-0llgr357	33	3	of	of	IN
cord-017585-0llgr357	33	4	membrane	membrane	NN
cord-017585-0llgr357	33	5	-	-	HYPH
cord-017585-0llgr357	33	6	bound	bind	VBN
cord-017585-0llgr357	33	7	ACE	ace	NN
cord-017585-0llgr357	33	8	to	to	IN
cord-017585-0llgr357	33	9	a	a	DT
cord-017585-0llgr357	33	10	soluble	soluble	JJ
cord-017585-0llgr357	33	11	form	form	NN
cord-017585-0llgr357	33	12	does	do	VBZ
cord-017585-0llgr357	33	13	not	not	RB
cord-017585-0llgr357	33	14	appear	appear	VB
cord-017585-0llgr357	33	15	to	to	TO
cord-017585-0llgr357	33	16	substantially	substantially	RB
cord-017585-0llgr357	33	17	alter	alter	VB
cord-017585-0llgr357	33	18	the	the	DT
cord-017585-0llgr357	33	19	substrate	substrate	JJ
cord-017585-0llgr357	33	20	preference	preference	NN
cord-017585-0llgr357	33	21	or	or	CC
cord-017585-0llgr357	33	22	the	the	DT
cord-017585-0llgr357	33	23	catalytic	catalytic	JJ
cord-017585-0llgr357	33	24	properties	property	NNS
cord-017585-0llgr357	33	25	of	of	IN
cord-017585-0llgr357	33	26	the	the	DT
cord-017585-0llgr357	33	27	enzyme	enzyme	NN
cord-017585-0llgr357	33	28	.	.	.
cord-017585-0llgr357	34	1	Although	although	IN
cord-017585-0llgr357	34	2	the	the	DT
cord-017585-0llgr357	34	3	significance	significance	NN
cord-017585-0llgr357	34	4	of	of	IN
cord-017585-0llgr357	34	5	this	this	DT
cord-017585-0llgr357	34	6	event	event	NN
cord-017585-0llgr357	34	7	is	be	VBZ
cord-017585-0llgr357	34	8	not	not	RB
cord-017585-0llgr357	34	9	currently	currently	RB
cord-017585-0llgr357	34	10	understood	understand	VBN
cord-017585-0llgr357	34	11	,	,	,
cord-017585-0llgr357	34	12	enzyme	enzyme	NN
cord-017585-0llgr357	34	13	shedding	shedding	NN
cord-017585-0llgr357	34	14	may	may	MD
cord-017585-0llgr357	34	15	underlie	underlie	VB
cord-017585-0llgr357	34	16	an	an	DT
cord-017585-0llgr357	34	17	endocrine	endocrine	JJ
cord-017585-0llgr357	34	18	process	process	NN
cord-017585-0llgr357	34	19	to	to	TO
cord-017585-0llgr357	34	20	transport	transport	VB
cord-017585-0llgr357	34	21	ACE	ace	NN
cord-017585-0llgr357	34	22	to	to	IN
cord-017585-0llgr357	34	23	more	more	RBR
cord-017585-0llgr357	34	24	distal	distal	JJ
cord-017585-0llgr357	34	25	areas	area	NNS
cord-017585-0llgr357	34	26	of	of	IN
cord-017585-0llgr357	34	27	the	the	DT
cord-017585-0llgr357	34	28	nephron	nephron	NN
cord-017585-0llgr357	34	29	that	that	WDT
cord-017585-0llgr357	34	30	are	be	VBP
cord-017585-0llgr357	34	31	deficient	deficient	JJ
cord-017585-0llgr357	34	32	in	in	IN
cord-017585-0llgr357	34	33	this	this	DT
cord-017585-0llgr357	34	34	peptidase	peptidase	NN
cord-017585-0llgr357	34	35	activity	activity	NN
cord-017585-0llgr357	34	36	for	for	IN
cord-017585-0llgr357	34	37	the	the	DT
cord-017585-0llgr357	34	38	discrete	discrete	JJ
cord-017585-0llgr357	34	39	production	production	NN
cord-017585-0llgr357	34	40	of	of	IN
cord-017585-0llgr357	34	41	Ang	Ang	NNP
cord-017585-0llgr357	34	42	II	II	NNP
cord-017585-0llgr357	34	43	.	.	.
cord-017585-0llgr357	35	1	In	in	IN
cord-017585-0llgr357	35	2	this	this	DT
cord-017585-0llgr357	35	3	regard	regard	NN
cord-017585-0llgr357	35	4	,	,	,
cord-017585-0llgr357	35	5	Casarini	Casarini	NNP
cord-017585-0llgr357	35	6	and	and	CC
cord-017585-0llgr357	35	7	colleagues	colleague	NNS
cord-017585-0llgr357	35	8	have	have	VBP
cord-017585-0llgr357	35	9	presented	present	VBN
cord-017585-0llgr357	35	10	intriguing	intriguing	JJ
cord-017585-0llgr357	35	11	data	datum	NNS
cord-017585-0llgr357	35	12	that	that	IN
cord-017585-0llgr357	35	13	the	the	DT
cord-017585-0llgr357	35	14	urinary	urinary	JJ
cord-017585-0llgr357	35	15	excretion	excretion	NN
cord-017585-0llgr357	35	16	of	of	IN
cord-017585-0llgr357	35	17	the	the	DT
cord-017585-0llgr357	35	18	N	n	CD
cord-017585-0llgr357	35	19	-	-	HYPH
cord-017585-0llgr357	35	20	terminal	terminal	NN
cord-017585-0llgr357	35	21	domain	domain	NN
cord-017585-0llgr357	35	22	of	of	IN
cord-017585-0llgr357	35	23	ACE	ACE	NNP
cord-017585-0llgr357	35	24	may	may	MD
cord-017585-0llgr357	35	25	serve	serve	VB
cord-017585-0llgr357	35	26	as	as	IN
cord-017585-0llgr357	35	27	a	a	DT
cord-017585-0llgr357	35	28	urinary	urinary	JJ
cord-017585-0llgr357	35	29	marker	marker	NN
cord-017585-0llgr357	35	30	in	in	IN
cord-017585-0llgr357	35	31	both	both	DT
cord-017585-0llgr357	35	32	humans	human	NNS
cord-017585-0llgr357	35	33	and	and	CC
cord-017585-0llgr357	35	34	experimental	experimental	JJ
cord-017585-0llgr357	35	35	hypertensive	hypertensive	JJ
cord-017585-0llgr357	35	36	models	model	NNS
cord-017585-0llgr357	35	37	(	(	-LRB-
cord-017585-0llgr357	35	38	Marques	Marques	NNP
cord-017585-0llgr357	35	39	et	et	NNP
cord-017585-0llgr357	35	40	al	al	NNP
cord-017585-0llgr357	35	41	2003	2003	CD
cord-017585-0llgr357	35	42	)	)	-RRB-
cord-017585-0llgr357	35	43	.	.	.
cord-017585-0llgr357	36	1	Extensive	extensive	JJ
cord-017585-0llgr357	36	2	evidence	evidence	NN
cord-017585-0llgr357	36	3	suggests	suggest	VBZ
cord-017585-0llgr357	36	4	that	that	IN
cord-017585-0llgr357	36	5	intrarenal	intrarenal	NNP
cord-017585-0llgr357	36	6	ACE	ACE	NNP
cord-017585-0llgr357	36	7	participates	participate	VBZ
cord-017585-0llgr357	36	8	in	in	IN
cord-017585-0llgr357	36	9	the	the	DT
cord-017585-0llgr357	36	10	direct	direct	JJ
cord-017585-0llgr357	36	11	formation	formation	NN
cord-017585-0llgr357	36	12	of	of	IN
cord-017585-0llgr357	36	13	Ang	Ang	NNP
cord-017585-0llgr357	36	14	II	II	NNP
cord-017585-0llgr357	36	15	from	from	IN
cord-017585-0llgr357	36	16	Ang	Ang	NNP
cord-017585-0llgr357	36	17	I.	I.	NNP
cord-017585-0llgr357	37	1	The	the	DT
cord-017585-0llgr357	37	2	renal	renal	JJ
cord-017585-0llgr357	37	3	administration	administration	NN
cord-017585-0llgr357	37	4	of	of	IN
cord-017585-0llgr357	37	5	ACE	ACE	NNP
cord-017585-0llgr357	37	6	inhibitors	inhibitor	NNS
cord-017585-0llgr357	37	7	reduces	reduce	VBZ
cord-017585-0llgr357	37	8	interstitial	interstitial	JJ
cord-017585-0llgr357	37	9	levels	level	NNS
cord-017585-0llgr357	37	10	of	of	IN
cord-017585-0llgr357	37	11	Ang	Ang	NNP
cord-017585-0llgr357	37	12	II	II	NNP
cord-017585-0llgr357	37	13	and	and	CC
cord-017585-0llgr357	37	14	attenuates	attenuate	VBZ
cord-017585-0llgr357	37	15	blood	blood	NN
cord-017585-0llgr357	37	16	pressure	pressure	NN
cord-017585-0llgr357	37	17	.	.	.
cord-017585-0llgr357	38	1	Moreover	moreover	RB
cord-017585-0llgr357	38	2	,	,	,
cord-017585-0llgr357	38	3	in	in	IN
cord-017585-0llgr357	38	4	an	an	DT
cord-017585-0llgr357	38	5	animal	animal	NN
cord-017585-0llgr357	38	6	model	model	NN
cord-017585-0llgr357	38	7	of	of	IN
cord-017585-0llgr357	38	8	tissue	tissue	NN
cord-017585-0llgr357	38	9	-	-	HYPH
cord-017585-0llgr357	38	10	depleted	deplete	VBN
cord-017585-0llgr357	38	11	ACE	ace	NN
cord-017585-0llgr357	38	12	that	that	WDT
cord-017585-0llgr357	38	13	preserves	preserve	VBZ
cord-017585-0llgr357	38	14	circulating	circulate	VBG
cord-017585-0llgr357	38	15	levels	level	NNS
cord-017585-0llgr357	38	16	of	of	IN
cord-017585-0llgr357	38	17	the	the	DT
cord-017585-0llgr357	38	18	enzyme	enzyme	NN
cord-017585-0llgr357	38	19	,	,	,
cord-017585-0llgr357	38	20	renal	renal	JJ
cord-017585-0llgr357	38	21	Ang	Ang	NNP
cord-017585-0llgr357	38	22	II	II	NNP
cord-017585-0llgr357	38	23	is	be	VBZ
cord-017585-0llgr357	38	24	significantly	significantly	RB
cord-017585-0llgr357	38	25	reduced	reduce	VBN
cord-017585-0llgr357	39	1	(	(	-LRB-
cord-017585-0llgr357	39	2	Modrall	Modrall	NNP
cord-017585-0llgr357	39	3	et	et	NNP
cord-017585-0llgr357	39	4	al	al	NNP
cord-017585-0llgr357	39	5	2003	2003	CD
cord-017585-0llgr357	39	6	)	)	-RRB-
cord-017585-0llgr357	39	7	.	.	.
cord-017585-0llgr357	40	1	Interestingly	interestingly	RB
cord-017585-0llgr357	40	2	,	,	,
cord-017585-0llgr357	40	3	intrarenal	intrarenal	JJ
cord-017585-0llgr357	40	4	levels	level	NNS
cord-017585-0llgr357	40	5	of	of	IN
cord-017585-0llgr357	40	6	Ang	Ang	NNP
cord-017585-0llgr357	40	7	I	-PRON-	PRP
cord-017585-0llgr357	40	8	were	be	VBD
cord-017585-0llgr357	40	9	also	also	RB
cord-017585-0llgr357	40	10	markedly	markedly	RB
cord-017585-0llgr357	40	11	reduced	reduce	VBN
cord-017585-0llgr357	40	12	in	in	IN
cord-017585-0llgr357	40	13	the	the	DT
cord-017585-0llgr357	40	14	tissue	tissue	NN
cord-017585-0llgr357	40	15	ACE	ace	NN
cord-017585-0llgr357	40	16	null	null	JJ
cord-017585-0llgr357	40	17	mouse	mouse	NN
cord-017585-0llgr357	40	18	while	while	IN
cord-017585-0llgr357	40	19	renal	renal	JJ
cord-017585-0llgr357	40	20	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	40	21	-	-	HYPH
cord-017585-0llgr357	40	22	7	7	CD
cord-017585-0llgr357	40	23	)	)	-RRB-
cord-017585-0llgr357	40	24	concentrations	concentration	NNS
cord-017585-0llgr357	40	25	were	be	VBD
cord-017585-0llgr357	40	26	maintained	maintain	VBN
cord-017585-0llgr357	41	1	(	(	-LRB-
cord-017585-0llgr357	41	2	Modrall	Modrall	NNP
cord-017585-0llgr357	41	3	et	et	NNP
cord-017585-0llgr357	41	4	al	al	NNP
cord-017585-0llgr357	41	5	2003	2003	CD
cord-017585-0llgr357	41	6	)	)	-RRB-
cord-017585-0llgr357	41	7	.	.	.
cord-017585-0llgr357	42	1	These	these	DT
cord-017585-0llgr357	42	2	data	datum	NNS
cord-017585-0llgr357	42	3	serve	serve	VBP
cord-017585-0llgr357	42	4	to	to	TO
cord-017585-0llgr357	42	5	emphasize	emphasize	VB
cord-017585-0llgr357	42	6	that	that	IN
cord-017585-0llgr357	42	7	ACE	ACE	NNP
cord-017585-0llgr357	42	8	participates	participate	VBZ
cord-017585-0llgr357	42	9	in	in	IN
cord-017585-0llgr357	42	10	the	the	DT
cord-017585-0llgr357	42	11	metabolism	metabolism	NN
cord-017585-0llgr357	42	12	of	of	IN
cord-017585-0llgr357	42	13	other	other	JJ
cord-017585-0llgr357	42	14	peptide	peptide	NN
cord-017585-0llgr357	42	15	hormones	hormone	NNS
cord-017585-0llgr357	42	16	(	(	-LRB-
cord-017585-0llgr357	42	17	Skidgel	Skidgel	NNP
cord-017585-0llgr357	42	18	&	&	CC
cord-017585-0llgr357	42	19	Erdos	Erdos	NNP
cord-017585-0llgr357	42	20	2004	2004	CD
cord-017585-0llgr357	42	21	)	)	-RRB-
cord-017585-0llgr357	42	22	.	.	.
cord-017585-0llgr357	43	1	In	in	IN
cord-017585-0llgr357	43	2	the	the	DT
cord-017585-0llgr357	43	3	case	case	NN
cord-017585-0llgr357	43	4	of	of	IN
cord-017585-0llgr357	43	5	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	43	6	-	-	HYPH
cord-017585-0llgr357	43	7	7	7	CD
cord-017585-0llgr357	43	8	)	)	-RRB-
cord-017585-0llgr357	43	9	,	,	,
cord-017585-0llgr357	43	10	ACE	ACE	NNP
cord-017585-0llgr357	43	11	efficiently	efficiently	RB
cord-017585-0llgr357	43	12	metabolizes	metabolize	VBZ
cord-017585-0llgr357	43	13	the	the	DT
cord-017585-0llgr357	43	14	peptide	peptide	NN
cord-017585-0llgr357	43	15	to	to	IN
cord-017585-0llgr357	43	16	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	43	17	-	-	HYPH
cord-017585-0llgr357	43	18	5	5	CD
cord-017585-0llgr357	43	19	)	)	-RRB-
cord-017585-0llgr357	43	20	,	,	,
cord-017585-0llgr357	43	21	a	a	DT
cord-017585-0llgr357	43	22	product	product	NN
cord-017585-0llgr357	43	23	which	which	WDT
cord-017585-0llgr357	43	24	is	be	VBZ
cord-017585-0llgr357	43	25	presently	presently	RB
cord-017585-0llgr357	43	26	not	not	RB
cord-017585-0llgr357	43	27	known	know	VBN
cord-017585-0llgr357	43	28	to	to	TO
cord-017585-0llgr357	43	29	exhibit	exhibit	VB
cord-017585-0llgr357	43	30	functional	functional	JJ
cord-017585-0llgr357	43	31	activity	activity	NN
cord-017585-0llgr357	44	1	Deddish	Deddish	NNP
cord-017585-0llgr357	44	2	et	et	NNP
cord-017585-0llgr357	44	3	al	al	NNP
cord-017585-0llgr357	44	4	1998	1998	CD
cord-017585-0llgr357	44	5	;	;	:
cord-017585-0llgr357	44	6	Rice	Rice	NNP
cord-017585-0llgr357	44	7	et	et	NNP
cord-017585-0llgr357	44	8	al	al	NNP
cord-017585-0llgr357	44	9	2004	2004	CD
cord-017585-0llgr357	44	10	)	)	-RRB-
cord-017585-0llgr357	44	11	.	.	.
cord-017585-0llgr357	45	1	We	-PRON-	PRP
cord-017585-0llgr357	45	2	have	have	VBP
cord-017585-0llgr357	45	3	postulated	postulate	VBN
cord-017585-0llgr357	45	4	that	that	IN
cord-017585-0llgr357	45	5	the	the	DT
cord-017585-0llgr357	45	6	formation	formation	NN
cord-017585-0llgr357	45	7	of	of	IN
cord-017585-0llgr357	45	8	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	45	9	-	-	HYPH
cord-017585-0llgr357	45	10	7	7	CD
cord-017585-0llgr357	45	11	)	)	-RRB-
cord-017585-0llgr357	45	12	,	,	,
cord-017585-0llgr357	45	13	particularly	particularly	RB
cord-017585-0llgr357	45	14	under	under	IN
cord-017585-0llgr357	45	15	prolonged	prolonged	JJ
cord-017585-0llgr357	45	16	activation	activation	NN
cord-017585-0llgr357	45	17	of	of	IN
cord-017585-0llgr357	45	18	the	the	DT
cord-017585-0llgr357	45	19	RAAS	raa	NNS
cord-017585-0llgr357	45	20	,	,	,
cord-017585-0llgr357	45	21	is	be	VBZ
cord-017585-0llgr357	45	22	considered	consider	VBN
cord-017585-0llgr357	45	23	to	to	TO
cord-017585-0llgr357	45	24	balance	balance	VB
cord-017585-0llgr357	45	25	or	or	CC
cord-017585-0llgr357	45	26	attenuate	attenuate	VB
cord-017585-0llgr357	45	27	the	the	DT
cord-017585-0llgr357	45	28	constrictor	constrictor	NN
cord-017585-0llgr357	45	29	and	and	CC
cord-017585-0llgr357	45	30	proliferative	proliferative	JJ
cord-017585-0llgr357	45	31	actions	action	NNS
cord-017585-0llgr357	45	32	of	of	IN
cord-017585-0llgr357	45	33	Ang	Ang	NNP
cord-017585-0llgr357	45	34	II	II	NNP
cord-017585-0llgr357	45	35	Ferrario	Ferrario	NNP
cord-017585-0llgr357	45	36	et	et	NNP
cord-017585-0llgr357	45	37	al	al	NNP
cord-017585-0llgr357	45	38	2005c	2005c	CD
cord-017585-0llgr357	45	39	)	)	-RRB-
cord-017585-0llgr357	45	40	.	.	.
cord-017585-0llgr357	46	1	Indeed	indeed	RB
cord-017585-0llgr357	46	2	,	,	,
cord-017585-0llgr357	46	3	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	46	4	-	-	HYPH
cord-017585-0llgr357	46	5	7	7	CD
cord-017585-0llgr357	46	6	)	)	-RRB-
cord-017585-0llgr357	46	7	exhibits	exhibit	VBZ
cord-017585-0llgr357	46	8	vasodilatory	vasodilatory	NN
cord-017585-0llgr357	46	9	,	,	,
cord-017585-0llgr357	46	10	natriuretic	natriuretic	JJ
cord-017585-0llgr357	46	11	and	and	CC
cord-017585-0llgr357	46	12	anti	anti	JJ
cord-017585-0llgr357	46	13	-	-	JJ
cord-017585-0llgr357	46	14	proliferative	proliferative	JJ
cord-017585-0llgr357	46	15	actions	action	NNS
cord-017585-0llgr357	46	16	through	through	IN
cord-017585-0llgr357	46	17	the	the	DT
cord-017585-0llgr357	46	18	stimulation	stimulation	NN
cord-017585-0llgr357	46	19	of	of	IN
cord-017585-0llgr357	46	20	nitric	nitric	NN
cord-017585-0llgr357	46	21	oxide	oxide	NN
cord-017585-0llgr357	46	22	and	and	CC
cord-017585-0llgr357	46	23	arachidonic	arachidonic	JJ
cord-017585-0llgr357	46	24	acid	acid	NN
cord-017585-0llgr357	46	25	metabolites	metabolite	NNS
cord-017585-0llgr357	46	26	(	(	-LRB-
cord-017585-0llgr357	46	27	Sampaio	Sampaio	NNP
cord-017585-0llgr357	46	28	et	et	NNP
cord-017585-0llgr357	46	29	al	al	NNP
cord-017585-0llgr357	46	30	2007	2007	CD
cord-017585-0llgr357	46	31	)	)	-RRB-
cord-017585-0llgr357	46	32	.	.	.
cord-017585-0llgr357	47	1	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	47	2	-	-	HYPH
cord-017585-0llgr357	47	3	7	7	CD
cord-017585-0llgr357	47	4	)	)	-RRB-
cord-017585-0llgr357	47	5	abrogates	abrogate	VBZ
cord-017585-0llgr357	47	6	the	the	DT
cord-017585-0llgr357	47	7	Ang	Ang	NNP
cord-017585-0llgr357	47	8	II	II	NNP
cord-017585-0llgr357	47	9	-	-	HYPH
cord-017585-0llgr357	47	10	dependent	dependent	JJ
cord-017585-0llgr357	47	11	activation	activation	NN
cord-017585-0llgr357	47	12	of	of	IN
cord-017585-0llgr357	47	13	MAP	MAP	NNP
cord-017585-0llgr357	47	14	kinase	kinase	NN
cord-017585-0llgr357	47	15	in	in	IN
cord-017585-0llgr357	47	16	primary	primary	JJ
cord-017585-0llgr357	47	17	cultures	culture	NNS
cord-017585-0llgr357	47	18	of	of	IN
cord-017585-0llgr357	47	19	proximal	proximal	JJ
cord-017585-0llgr357	47	20	tubule	tubule	NN
cord-017585-0llgr357	47	21	epithelial	epithelial	JJ
cord-017585-0llgr357	47	22	cells	cell	NNS
cord-017585-0llgr357	47	23	(	(	-LRB-
cord-017585-0llgr357	47	24	Su	Su	NNP
cord-017585-0llgr357	47	25	et	et	FW
cord-017585-0llgr357	47	26	al	al	NNP
cord-017585-0llgr357	47	27	2006	2006	CD
cord-017585-0llgr357	47	28	)	)	-RRB-
cord-017585-0llgr357	47	29	.	.	.
cord-017585-0llgr357	48	1	Moreover	moreover	RB
cord-017585-0llgr357	48	2	,	,	,
cord-017585-0llgr357	48	3	the	the	DT
cord-017585-0llgr357	48	4	inhibitory	inhibitory	JJ
cord-017585-0llgr357	48	5	actions	action	NNS
cord-017585-0llgr357	48	6	of	of	IN
cord-017585-0llgr357	48	7	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	48	8	-	-	HYPH
cord-017585-0llgr357	48	9	7	7	CD
cord-017585-0llgr357	48	10	)	)	-RRB-
cord-017585-0llgr357	48	11	were	be	VBD
cord-017585-0llgr357	48	12	blocked	block	VBN
cord-017585-0llgr357	48	13	by	by	IN
cord-017585-0llgr357	48	14	the	the	DT
cord-017585-0llgr357	48	15	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	48	16	-	-	HYPH
cord-017585-0llgr357	48	17	7	7	CD
cord-017585-0llgr357	48	18	)	)	-RRB-
cord-017585-0llgr357	48	19	antagonist	antagonist	NN
cord-017585-0llgr357	48	20	[	[	-LRB-
cord-017585-0llgr357	48	21	D	D	NNP
cord-017585-0llgr357	48	22	-	-	HYPH
cord-017585-0llgr357	48	23	Ala	Ala	NNP
cord-017585-0llgr357	48	24	7	7	CD
cord-017585-0llgr357	48	25	]	]	-RRB-
cord-017585-0llgr357	48	26	-Ang-(1	-Ang-(1	:
cord-017585-0llgr357	48	27	-	-	SYM
cord-017585-0llgr357	48	28	7	7	CD
cord-017585-0llgr357	48	29	)	)	-RRB-
cord-017585-0llgr357	48	30	suggesting	suggest	VBG
cord-017585-0llgr357	48	31	a	a	DT
cord-017585-0llgr357	48	32	receptor	receptor	NN
cord-017585-0llgr357	48	33	mediated	mediate	VBN
cord-017585-0llgr357	48	34	pathway	pathway	NN
cord-017585-0llgr357	48	35	distinct	distinct	JJ
cord-017585-0llgr357	48	36	from	from	IN
cord-017585-0llgr357	48	37	either	either	CC
cord-017585-0llgr357	48	38	AT	at	IN
cord-017585-0llgr357	48	39	1	1	CD
cord-017585-0llgr357	48	40	or	or	CC
cord-017585-0llgr357	48	41	AT	at	IN
cord-017585-0llgr357	48	42	2	2	CD
cord-017585-0llgr357	48	43	receptor	receptor	NN
cord-017585-0llgr357	48	44	subtypes	subtype	NNS
cord-017585-0llgr357	49	1	(	(	-LRB-
cord-017585-0llgr357	49	2	Su	Su	NNP
cord-017585-0llgr357	49	3	et	et	FW
cord-017585-0llgr357	49	4	al	al	NNP
cord-017585-0llgr357	49	5	2006	2006	CD
cord-017585-0llgr357	49	6	)	)	-RRB-
cord-017585-0llgr357	49	7	.	.	.
cord-017585-0llgr357	50	1	Similar	similar	JJ
cord-017585-0llgr357	50	2	effects	effect	NNS
cord-017585-0llgr357	50	3	of	of	IN
cord-017585-0llgr357	50	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	50	5	-	-	HYPH
cord-017585-0llgr357	50	6	7	7	CD
cord-017585-0llgr357	50	7	)	)	-RRB-
cord-017585-0llgr357	50	8	were	be	VBD
cord-017585-0llgr357	50	9	originally	originally	RB
cord-017585-0llgr357	50	10	demonstrated	demonstrate	VBN
cord-017585-0llgr357	50	11	in	in	IN
cord-017585-0llgr357	50	12	non	non	JJ
cord-017585-0llgr357	50	13	-	-	JJ
cord-017585-0llgr357	50	14	renal	renal	JJ
cord-017585-0llgr357	50	15	cells	cell	NNS
cord-017585-0llgr357	50	16	(	(	-LRB-
cord-017585-0llgr357	50	17	Tallant	Tallant	NNP
cord-017585-0llgr357	50	18	et	et	FW
cord-017585-0llgr357	50	19	al	al	NNP
cord-017585-0llgr357	50	20	2005a	2005a	CD
cord-017585-0llgr357	50	21	)	)	-RRB-
cord-017585-0llgr357	50	22	.	.	.
cord-017585-0llgr357	51	1	In	in	IN
cord-017585-0llgr357	51	2	the	the	DT
cord-017585-0llgr357	51	3	circulation	circulation	NN
cord-017585-0llgr357	51	4	,	,	,
cord-017585-0llgr357	51	5	ACE	ace	NN
cord-017585-0llgr357	51	6	inhibitors	inhibitor	NNS
cord-017585-0llgr357	51	7	increase	increase	VBP
cord-017585-0llgr357	51	8	circulating	circulate	VBG
cord-017585-0llgr357	51	9	levels	level	NNS
cord-017585-0llgr357	51	10	of	of	IN
cord-017585-0llgr357	51	11	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	51	12	-	-	HYPH
cord-017585-0llgr357	51	13	7	7	CD
cord-017585-0llgr357	51	14	)	)	-RRB-
cord-017585-0llgr357	51	15	and	and	CC
cord-017585-0llgr357	51	16	augment	augment	VB
cord-017585-0llgr357	51	17	the	the	DT
cord-017585-0llgr357	51	18	in	in	IN
cord-017585-0llgr357	51	19	vivo	vivo	NN
cord-017585-0llgr357	51	20	half	half	NN
cord-017585-0llgr357	51	21	life	life	NN
cord-017585-0llgr357	51	22	of	of	IN
cord-017585-0llgr357	51	23	the	the	DT
cord-017585-0llgr357	51	24	peptide	peptide	NN
cord-017585-0llgr357	51	25	by	by	IN
cord-017585-0llgr357	51	26	almost	almost	RB
cord-017585-0llgr357	51	27	6	6	CD
cord-017585-0llgr357	51	28	fold	fold	NN
cord-017585-0llgr357	51	29	Yamada	Yamada	NNP
cord-017585-0llgr357	51	30	et	et	FW
cord-017585-0llgr357	51	31	al	al	NNP
cord-017585-0llgr357	51	32	1998	1998	CD
cord-017585-0llgr357	51	33	)	)	-RRB-
cord-017585-0llgr357	51	34	.	.	.
cord-017585-0llgr357	52	1	The	the	DT
cord-017585-0llgr357	52	2	urinary	urinary	JJ
cord-017585-0llgr357	52	3	excretion	excretion	NN
cord-017585-0llgr357	52	4	of	of	IN
cord-017585-0llgr357	52	5	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	52	6	-	-	HYPH
cord-017585-0llgr357	52	7	7	7	CD
cord-017585-0llgr357	52	8	)	)	-RRB-
cord-017585-0llgr357	52	9	increases	increase	VBZ
cord-017585-0llgr357	52	10	in	in	IN
cord-017585-0llgr357	52	11	both	both	DT
cord-017585-0llgr357	52	12	human	human	JJ
cord-017585-0llgr357	52	13	and	and	CC
cord-017585-0llgr357	52	14	experimental	experimental	JJ
cord-017585-0llgr357	52	15	hypertensive	hypertensive	JJ
cord-017585-0llgr357	52	16	models	model	NNS
cord-017585-0llgr357	52	17	following	follow	VBG
cord-017585-0llgr357	52	18	acute	acute	JJ
cord-017585-0llgr357	52	19	administration	administration	NN
cord-017585-0llgr357	52	20	of	of	IN
cord-017585-0llgr357	52	21	ACE	ACE	NNP
cord-017585-0llgr357	52	22	inhibitors	inhibitor	NNS
cord-017585-0llgr357	52	23	Yamada	Yamada	NNP
cord-017585-0llgr357	52	24	et	et	NNP
cord-017585-0llgr357	52	25	al	al	NNP
cord-017585-0llgr357	52	26	1999	1999	CD
cord-017585-0llgr357	52	27	)	)	-RRB-
cord-017585-0llgr357	52	28	.	.	.
cord-017585-0llgr357	53	1	The	the	DT
cord-017585-0llgr357	53	2	increased	increase	VBN
cord-017585-0llgr357	53	3	excretion	excretion	NN
cord-017585-0llgr357	53	4	of	of	IN
cord-017585-0llgr357	53	5	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	53	6	-	-	HYPH
cord-017585-0llgr357	53	7	7	7	CD
cord-017585-0llgr357	53	8	)	)	-RRB-
cord-017585-0llgr357	53	9	most	most	RBS
cord-017585-0llgr357	53	10	likely	likely	RB
cord-017585-0llgr357	53	11	reflects	reflect	VBZ
cord-017585-0llgr357	53	12	the	the	DT
cord-017585-0llgr357	53	13	reduced	reduce	VBN
cord-017585-0llgr357	53	14	intrarenal	intrarenal	JJ
cord-017585-0llgr357	53	15	metabolism	metabolism	NN
cord-017585-0llgr357	53	16	of	of	IN
cord-017585-0llgr357	53	17	the	the	DT
cord-017585-0llgr357	53	18	peptide	peptide	NN
cord-017585-0llgr357	53	19	and	and	CC
cord-017585-0llgr357	53	20	the	the	DT
cord-017585-0llgr357	53	21	efficient	efficient	JJ
cord-017585-0llgr357	53	22	shunting	shunting	NN
cord-017585-0llgr357	53	23	of	of	IN
cord-017585-0llgr357	53	24	the	the	DT
cord-017585-0llgr357	53	25	Ang	Ang	NNP
cord-017585-0llgr357	53	26	I	-PRON-	PRP
cord-017585-0llgr357	53	27	pathway	pathway	VBP
cord-017585-0llgr357	53	28	to	to	IN
cord-017585-0llgr357	53	29	formation	formation	NN
cord-017585-0llgr357	53	30	of	of	IN
cord-017585-0llgr357	53	31	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	53	32	-	-	HYPH
cord-017585-0llgr357	53	33	7	7	CD
cord-017585-0llgr357	53	34	)	)	-RRB-
cord-017585-0llgr357	53	35	.	.	.
cord-017585-0llgr357	54	1	Our	-PRON-	PRP$
cord-017585-0llgr357	54	2	recent	recent	JJ
cord-017585-0llgr357	54	3	studies	study	NNS
cord-017585-0llgr357	54	4	in	in	IN
cord-017585-0llgr357	54	5	isolated	isolated	JJ
cord-017585-0llgr357	54	6	sheep	sheep	NN
cord-017585-0llgr357	54	7	proximal	proximal	JJ
cord-017585-0llgr357	54	8	tubules	tubule	NNS
cord-017585-0llgr357	54	9	reveal	reveal	VBP
cord-017585-0llgr357	54	10	that	that	IN
cord-017585-0llgr357	54	11	without	without	IN
cord-017585-0llgr357	54	12	prior	prior	JJ
cord-017585-0llgr357	54	13	inhibition	inhibition	NN
cord-017585-0llgr357	54	14	of	of	IN
cord-017585-0llgr357	54	15	ACE	ACE	NNP
cord-017585-0llgr357	54	16	,	,	,
cord-017585-0llgr357	54	17	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	54	18	-	-	HYPH
cord-017585-0llgr357	54	19	7	7	CD
cord-017585-0llgr357	54	20	)	)	-RRB-
cord-017585-0llgr357	54	21	derived	derive	VBN
cord-017585-0llgr357	54	22	from	from	IN
cord-017585-0llgr357	54	23	either	either	DT
cord-017585-0llgr357	54	24	Ang	Ang	NNP
cord-017585-0llgr357	54	25	I	I	NNP
cord-017585-0llgr357	54	26	or	or	CC
cord-017585-0llgr357	54	27	Ang	Ang	NNP
cord-017585-0llgr357	54	28	II	II	NNP
cord-017585-0llgr357	54	29	was	be	VBD
cord-017585-0llgr357	54	30	rapidly	rapidly	RB
cord-017585-0llgr357	54	31	converted	convert	VBN
cord-017585-0llgr357	54	32	to	to	IN
cord-017585-0llgr357	54	33	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	54	34	-	-	HYPH
cord-017585-0llgr357	54	35	5	5	CD
cord-017585-0llgr357	54	36	)	)	-RRB-
cord-017585-0llgr357	55	1	(	(	-LRB-
cord-017585-0llgr357	55	2	Shaltout	Shaltout	NNP
cord-017585-0llgr357	55	3	et	et	NNP
cord-017585-0llgr357	55	4	al	al	NNP
cord-017585-0llgr357	55	5	2007	2007	CD
cord-017585-0llgr357	55	6	)	)	-RRB-
cord-017585-0llgr357	55	7	.	.	.
cord-017585-0llgr357	56	1	Blockade	blockade	NN
cord-017585-0llgr357	56	2	of	of	IN
cord-017585-0llgr357	56	3	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	56	4	-	-	HYPH
cord-017585-0llgr357	56	5	7	7	NNP
cord-017585-0llgr357	56	6	)	)	-RRB-
cord-017585-0llgr357	56	7	partially	partially	RB
cord-017585-0llgr357	56	8	reverses	reverse	VBZ
cord-017585-0llgr357	56	9	the	the	DT
cord-017585-0llgr357	56	10	beneficial	beneficial	JJ
cord-017585-0llgr357	56	11	actions	action	NNS
cord-017585-0llgr357	56	12	of	of	IN
cord-017585-0llgr357	56	13	ACE	ace	NN
cord-017585-0llgr357	56	14	inhibitors	inhibitor	NNS
cord-017585-0llgr357	56	15	on	on	IN
cord-017585-0llgr357	56	16	blood	blood	NN
cord-017585-0llgr357	56	17	pressure	pressure	NN
cord-017585-0llgr357	56	18	in	in	IN
cord-017585-0llgr357	56	19	hypertensive	hypertensive	JJ
cord-017585-0llgr357	56	20	rats	rat	NNS
cord-017585-0llgr357	56	21	as	as	IN
cord-017585-0llgr357	56	22	an	an	DT
cord-017585-0llgr357	56	23	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	56	24	-	-	HYPH
cord-017585-0llgr357	56	25	7	7	CD
cord-017585-0llgr357	56	26	)	)	-RRB-
cord-017585-0llgr357	56	27	monoclonal	monoclonal	JJ
cord-017585-0llgr357	56	28	antibody	antibody	NN
cord-017585-0llgr357	56	29	or	or	CC
cord-017585-0llgr357	56	30	the	the	DT
cord-017585-0llgr357	56	31	[	[	-LRB-
cord-017585-0llgr357	56	32	D	D	NNP
cord-017585-0llgr357	56	33	-	-	HYPH
cord-017585-0llgr357	56	34	Ala	Ala	NNP
cord-017585-0llgr357	56	35	7	7	CD
cord-017585-0llgr357	56	36	]	]	-RRB-
cord-017585-0llgr357	56	37	-Ang-(1	-Ang-(1	:
cord-017585-0llgr357	56	38	-	-	SYM
cord-017585-0llgr357	56	39	7	7	CD
cord-017585-0llgr357	57	1	)	)	-RRB-
cord-017585-0llgr357	57	2	antagonist	antagonist	NN
cord-017585-0llgr357	57	3	increase	increase	NN
cord-017585-0llgr357	57	4	blood	blood	NN
cord-017585-0llgr357	57	5	pressure	pressure	NN
cord-017585-0llgr357	57	6	(	(	-LRB-
cord-017585-0llgr357	57	7	Iyer	Iyer	NNP
cord-017585-0llgr357	57	8	et	et	NNP
cord-017585-0llgr357	57	9	al	al	NNP
cord-017585-0llgr357	57	10	1997	1997	CD
cord-017585-0llgr357	57	11	;	;	:
cord-017585-0llgr357	57	12	Iyer	Iyer	NNP
cord-017585-0llgr357	57	13	et	et	NNP
cord-017585-0llgr357	57	14	al	al	NNP
cord-017585-0llgr357	57	15	2000	2000	CD
cord-017585-0llgr357	57	16	)	)	-RRB-
cord-017585-0llgr357	57	17	.	.	.
cord-017585-0llgr357	58	1	Moreover	moreover	RB
cord-017585-0llgr357	58	2	,	,	,
cord-017585-0llgr357	58	3	studies	study	NNS
cord-017585-0llgr357	58	4	by	by	IN
cord-017585-0llgr357	58	5	Benter	Benter	NNP
cord-017585-0llgr357	58	6	and	and	CC
cord-017585-0llgr357	58	7	colleagues	colleague	NNS
cord-017585-0llgr357	58	8	find	find	VBP
cord-017585-0llgr357	58	9	that	that	IN
cord-017585-0llgr357	58	10	the	the	DT
cord-017585-0llgr357	58	11	renoprotective	renoprotective	NN
cord-017585-0llgr357	58	12	effects	effect	NNS
cord-017585-0llgr357	58	13	of	of	IN
cord-017585-0llgr357	58	14	exogenous	exogenous	JJ
cord-017585-0llgr357	58	15	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	58	16	-	-	HYPH
cord-017585-0llgr357	58	17	7	7	CD
cord-017585-0llgr357	58	18	)	)	-RRB-
cord-017585-0llgr357	58	19	in	in	IN
cord-017585-0llgr357	58	20	LNAME	LNAME	NNP
cord-017585-0llgr357	58	21	-	-	HYPH
cord-017585-0llgr357	58	22	treated	treat	VBN
cord-017585-0llgr357	58	23	SHR	SHR	NNP
cord-017585-0llgr357	58	24	were	be	VBD
cord-017585-0llgr357	58	25	not	not	RB
cord-017585-0llgr357	58	26	further	further	RB
cord-017585-0llgr357	58	27	improved	improve	VBN
cord-017585-0llgr357	58	28	with	with	IN
cord-017585-0llgr357	58	29	the	the	DT
cord-017585-0llgr357	58	30	ACE	ACE	NNP
cord-017585-0llgr357	58	31	inhibitor	inhibitor	NN
cord-017585-0llgr357	58	32	captopril	captopril	NN
cord-017585-0llgr357	58	33	(	(	-LRB-
cord-017585-0llgr357	58	34	Benter	Benter	NNP
cord-017585-0llgr357	58	35	et	et	NNP
cord-017585-0llgr357	58	36	al	al	NNP
cord-017585-0llgr357	58	37	2006a	2006a	CD
cord-017585-0llgr357	58	38	)	)	-RRB-
cord-017585-0llgr357	58	39	.	.	.
cord-017585-0llgr357	59	1	Apart	apart	RB
cord-017585-0llgr357	59	2	from	from	IN
cord-017585-0llgr357	59	3	Ang	Ang	NNP
cord-017585-0llgr357	59	4	II	II	NNP
cord-017585-0llgr357	59	5	and	and	CC
cord-017585-0llgr357	59	6	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	59	7	-	-	HYPH
cord-017585-0llgr357	59	8	7	7	CD
cord-017585-0llgr357	59	9	)	)	-RRB-
cord-017585-0llgr357	59	10	,	,	,
cord-017585-0llgr357	59	11	renal	renal	JJ
cord-017585-0llgr357	59	12	ACE	ace	NN
cord-017585-0llgr357	59	13	may	may	MD
cord-017585-0llgr357	59	14	also	also	RB
cord-017585-0llgr357	59	15	participate	participate	VB
cord-017585-0llgr357	59	16	in	in	IN
cord-017585-0llgr357	59	17	the	the	DT
cord-017585-0llgr357	59	18	metabolism	metabolism	NN
cord-017585-0llgr357	59	19	of	of	IN
cord-017585-0llgr357	59	20	other	other	JJ
cord-017585-0llgr357	59	21	peptides	peptide	NNS
cord-017585-0llgr357	59	22	including	include	VBG
cord-017585-0llgr357	59	23	kinins	kinin	NNS
cord-017585-0llgr357	59	24	,	,	,
cord-017585-0llgr357	59	25	substance	substance	NN
cord-017585-0llgr357	59	26	P	p	NN
cord-017585-0llgr357	59	27	and	and	CC
cord-017585-0llgr357	59	28	the	the	DT
cord-017585-0llgr357	59	29	hematopoietic	hematopoietic	JJ
cord-017585-0llgr357	59	30	fragment	fragment	NN
cord-017585-0llgr357	59	31	acetyl	acetyl	NN
cord-017585-0llgr357	59	32	-	-	HYPH
cord-017585-0llgr357	59	33	Ser	Ser	NNP
cord-017585-0llgr357	59	34	-	-	HYPH
cord-017585-0llgr357	59	35	Asp	Asp	NNP
cord-017585-0llgr357	59	36	-	-	HYPH
cord-017585-0llgr357	59	37	Lys	Lys	NNP
cord-017585-0llgr357	59	38	-	-	HYPH
cord-017585-0llgr357	59	39	Pro	Pro	NNP
cord-017585-0llgr357	59	40	(	(	-LRB-
cord-017585-0llgr357	59	41	Ac	Ac	NNP
cord-017585-0llgr357	59	42	-	-	HYPH
cord-017585-0llgr357	59	43	SDKP	SDKP	NNP
cord-017585-0llgr357	59	44	)	)	-RRB-
cord-017585-0llgr357	59	45	.	.	.
cord-017585-0llgr357	60	1	Bradykinin-(1	Bradykinin-(1	NNP
cord-017585-0llgr357	60	2	-	-	HYPH
cord-017585-0llgr357	60	3	9	9	CD
cord-017585-0llgr357	60	4	)	)	-RRB-
cord-017585-0llgr357	60	5	is	be	VBZ
cord-017585-0llgr357	60	6	very	very	RB
cord-017585-0llgr357	60	7	rapidly	rapidly	RB
cord-017585-0llgr357	60	8	metabolized	metabolize	VBN
cord-017585-0llgr357	60	9	by	by	IN
cord-017585-0llgr357	60	10	ACE	ACE	NNP
cord-017585-0llgr357	60	11	in	in	IN
cord-017585-0llgr357	60	12	a	a	DT
cord-017585-0llgr357	60	13	two	two	CD
cord-017585-0llgr357	60	14	-step	-step	NN
cord-017585-0llgr357	60	15	process	process	NN
cord-017585-0llgr357	60	16	to	to	IN
cord-017585-0llgr357	60	17	the	the	DT
cord-017585-0llgr357	60	18	inactive	inactive	JJ
cord-017585-0llgr357	60	19	fragments	fragment	NNS
cord-017585-0llgr357	60	20	bradykinin-(1	bradykinin-(1	NNP
cord-017585-0llgr357	60	21	-	-	SYM
cord-017585-0llgr357	60	22	7	7	CD
cord-017585-0llgr357	60	23	)	)	-RRB-
cord-017585-0llgr357	60	24	and	and	CC
cord-017585-0llgr357	60	25	bradykinin-(1	bradykinin-(1	CD
cord-017585-0llgr357	60	26	-	-	SYM
cord-017585-0llgr357	60	27	5	5	CD
cord-017585-0llgr357	60	28	)	)	-RRB-
cord-017585-0llgr357	60	29	.	.	.
cord-017585-0llgr357	61	1	ACE	ace	NN
cord-017585-0llgr357	61	2	inhibition	inhibition	NN
cord-017585-0llgr357	61	3	is	be	VBZ
cord-017585-0llgr357	61	4	associated	associate	VBN
cord-017585-0llgr357	61	5	with	with	IN
cord-017585-0llgr357	61	6	increased	increase	VBN
cord-017585-0llgr357	61	7	circulating	circulating	NN
cord-017585-0llgr357	61	8	and	and	CC
cord-017585-0llgr357	61	9	tissue	tissue	NN
cord-017585-0llgr357	61	10	levels	level	NNS
cord-017585-0llgr357	61	11	of	of	IN
cord-017585-0llgr357	61	12	bradykinin-(1	bradykinin-(1	NNP
cord-017585-0llgr357	61	13	-	-	SYM
cord-017585-0llgr357	61	14	9	9	CD
cord-017585-0llgr357	61	15	)	)	-RRB-
cord-017585-0llgr357	61	16	and	and	CC
cord-017585-0llgr357	61	17	the	the	DT
cord-017585-0llgr357	61	18	renal	renal	JJ
cord-017585-0llgr357	61	19	content	content	NN
cord-017585-0llgr357	61	20	of	of	IN
cord-017585-0llgr357	61	21	kinin	kinin	NNP
cord-017585-0llgr357	61	22	is	be	VBZ
cord-017585-0llgr357	61	23	higher	high	JJR
cord-017585-0llgr357	61	24	in	in	IN
cord-017585-0llgr357	61	25	the	the	DT
cord-017585-0llgr357	61	26	tissue	tissue	NN
cord-017585-0llgr357	61	27	ACE	ace	NN
cord-017585-0llgr357	61	28	null	null	JJ
cord-017585-0llgr357	61	29	mouse	mouse	NN
cord-017585-0llgr357	62	1	(	(	-LRB-
cord-017585-0llgr357	62	2	Campbell	Campbell	NNP
cord-017585-0llgr357	62	3	et	et	NNP
cord-017585-0llgr357	62	4	al	al	NNP
cord-017585-0llgr357	62	5	2004	2004	CD
cord-017585-0llgr357	62	6	)	)	-RRB-
cord-017585-0llgr357	62	7	.	.	.
cord-017585-0llgr357	63	1	In	in	IN
cord-017585-0llgr357	63	2	general	general	JJ
cord-017585-0llgr357	63	3	,	,	,
cord-017585-0llgr357	63	4	bradykinin	bradykinin	NN
cord-017585-0llgr357	63	5	is	be	VBZ
cord-017585-0llgr357	63	6	a	a	DT
cord-017585-0llgr357	63	7	potent	potent	JJ
cord-017585-0llgr357	63	8	vasodilator	vasodilator	NN
cord-017585-0llgr357	63	9	and	and	CC
cord-017585-0llgr357	63	10	inhibitor	inhibitor	NN
cord-017585-0llgr357	63	11	of	of	IN
cord-017585-0llgr357	63	12	cell	cell	NN
cord-017585-0llgr357	63	13	growth	growth	NN
cord-017585-0llgr357	63	14	through	through	IN
cord-017585-0llgr357	63	15	stimulation	stimulation	NN
cord-017585-0llgr357	63	16	of	of	IN
cord-017585-0llgr357	63	17	nitric	nitric	NN
cord-017585-0llgr357	63	18	oxide	oxide	NN
cord-017585-0llgr357	63	19	,	,	,
cord-017585-0llgr357	63	20	as	as	RB
cord-017585-0llgr357	63	21	well	well	RB
cord-017585-0llgr357	63	22	as	as	IN
cord-017585-0llgr357	63	23	exhibiting	exhibit	VBG
cord-017585-0llgr357	63	24	natriuretic	natriuretic	JJ
cord-017585-0llgr357	63	25	actions	action	NNS
cord-017585-0llgr357	63	26	within	within	IN
cord-017585-0llgr357	63	27	the	the	DT
cord-017585-0llgr357	63	28	kidney	kidney	NN
cord-017585-0llgr357	63	29	(	(	-LRB-
cord-017585-0llgr357	63	30	Scicli	Scicli	NNP
cord-017585-0llgr357	63	31	&	&	CC
cord-017585-0llgr357	63	32	Carretero	Carretero	NNP
cord-017585-0llgr357	63	33	1986	1986	CD
cord-017585-0llgr357	63	34	)	)	-RRB-
cord-017585-0llgr357	63	35	.	.	.
cord-017585-0llgr357	64	1	Interestingly	interestingly	RB
cord-017585-0llgr357	64	2	,	,	,
cord-017585-0llgr357	64	3	Santos	Santos	NNP
cord-017585-0llgr357	64	4	and	and	CC
cord-017585-0llgr357	64	5	colleagues	colleague	NNS
cord-017585-0llgr357	64	6	have	have	VBP
cord-017585-0llgr357	64	7	reported	report	VBN
cord-017585-0llgr357	64	8	that	that	IN
cord-017585-0llgr357	64	9	the	the	DT
cord-017585-0llgr357	64	10	functional	functional	JJ
cord-017585-0llgr357	64	11	activity	activity	NN
cord-017585-0llgr357	64	12	of	of	IN
cord-017585-0llgr357	64	13	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	64	14	-	-	HYPH
cord-017585-0llgr357	64	15	7	7	CD
cord-017585-0llgr357	64	16	)	)	-RRB-
cord-017585-0llgr357	64	17	,	,	,
cord-017585-0llgr357	64	18	under	under	IN
cord-017585-0llgr357	64	19	certain	certain	JJ
cord-017585-0llgr357	64	20	conditions	condition	NNS
cord-017585-0llgr357	64	21	,	,	,
cord-017585-0llgr357	64	22	is	be	VBZ
cord-017585-0llgr357	64	23	dependent	dependent	JJ
cord-017585-0llgr357	64	24	on	on	IN
cord-017585-0llgr357	64	25	the	the	DT
cord-017585-0llgr357	64	26	increased	increase	VBN
cord-017585-0llgr357	64	27	release	release	NN
cord-017585-0llgr357	64	28	of	of	IN
cord-017585-0llgr357	64	29	bradykinin	bradykinin	NN
cord-017585-0llgr357	64	30	(	(	-LRB-
cord-017585-0llgr357	64	31	Fernandes	Fernandes	NNP
cord-017585-0llgr357	64	32	et	et	NNP
cord-017585-0llgr357	64	33	al	al	NNP
cord-017585-0llgr357	64	34	2001	2001	CD
cord-017585-0llgr357	64	35	)	)	-RRB-
cord-017585-0llgr357	64	36	.	.	.
cord-017585-0llgr357	65	1	Moreover	moreover	RB
cord-017585-0llgr357	65	2	,	,	,
cord-017585-0llgr357	65	3	the	the	DT
cord-017585-0llgr357	65	4	kinin	kinin	NNP
cord-017585-0llgr357	65	5	B2	B2	NNP
cord-017585-0llgr357	65	6	receptor	receptor	NN
cord-017585-0llgr357	65	7	antagonist	antagonist	NN
cord-017585-0llgr357	65	8	HOE140	HOE140	NNP
cord-017585-0llgr357	65	9	blocked	block	VBD
cord-017585-0llgr357	65	10	nitric	nitric	NN
cord-017585-0llgr357	65	11	oxide	oxide	NN
cord-017585-0llgr357	65	12	release	release	NN
cord-017585-0llgr357	65	13	by	by	IN
cord-017585-0llgr357	65	14	the	the	DT
cord-017585-0llgr357	65	15	non	non	JJ
cord-017585-0llgr357	65	16	-	-	JJ
cord-017585-0llgr357	65	17	peptide	peptide	JJ
cord-017585-0llgr357	65	18	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	65	19	-	-	HYPH
cord-017585-0llgr357	65	20	7	7	CD
cord-017585-0llgr357	65	21	)	)	-RRB-
cord-017585-0llgr357	65	22	agonist	agonist	NN
cord-017585-0llgr357	66	1	AVE0991	AVE0991	NNP
cord-017585-0llgr357	67	1	(	(	-LRB-
cord-017585-0llgr357	67	2	Wiemer	Wiemer	NNP
cord-017585-0llgr357	67	3	et	et	NNP
cord-017585-0llgr357	67	4	al	al	NNP
cord-017585-0llgr357	67	5	2002	2002	CD
cord-017585-0llgr357	67	6	)	)	-RRB-
cord-017585-0llgr357	67	7	.	.	.
cord-017585-0llgr357	68	1	Similar	similar	JJ
cord-017585-0llgr357	68	2	to	to	IN
cord-017585-0llgr357	68	3	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	68	4	-	-	HYPH
cord-017585-0llgr357	68	5	7	7	CD
cord-017585-0llgr357	68	6	)	)	-RRB-
cord-017585-0llgr357	68	7	,	,	,
cord-017585-0llgr357	68	8	circulating	circulate	VBG
cord-017585-0llgr357	68	9	levels	level	NNS
cord-017585-0llgr357	68	10	of	of	IN
cord-017585-0llgr357	68	11	the	the	DT
cord-017585-0llgr357	68	12	Ac	Ac	NNP
cord-017585-0llgr357	68	13	-	-	HYPH
cord-017585-0llgr357	68	14	SDKP	SDKP	NNP
cord-017585-0llgr357	68	15	are	be	VBP
cord-017585-0llgr357	68	16	markedly	markedly	RB
cord-017585-0llgr357	68	17	increased	increase	VBN
cord-017585-0llgr357	68	18	with	with	IN
cord-017585-0llgr357	68	19	ACE	ace	NN
cord-017585-0llgr357	68	20	inhibition	inhibition	NN
cord-017585-0llgr357	68	21	and	and	CC
cord-017585-0llgr357	68	22	the	the	DT
cord-017585-0llgr357	68	23	enzyme	enzyme	NN
cord-017585-0llgr357	68	24	cleaves	cleave	VBZ
cord-017585-0llgr357	68	25	the	the	DT
cord-017585-0llgr357	68	26	Lys	Lys	NNP
cord-017585-0llgr357	68	27	-	-	HYPH
cord-017585-0llgr357	68	28	Pro	pro	JJ
cord-017585-0llgr357	68	29	bond	bond	NN
cord-017585-0llgr357	68	30	of	of	IN
cord-017585-0llgr357	68	31	the	the	DT
cord-017585-0llgr357	68	32	tetrapeptide	tetrapeptide	NN
cord-017585-0llgr357	68	33	(	(	-LRB-
cord-017585-0llgr357	68	34	Azizi	Azizi	NNP
cord-017585-0llgr357	68	35	et	et	NNP
cord-017585-0llgr357	68	36	al	al	NNP
cord-017585-0llgr357	68	37	1997	1997	CD
cord-017585-0llgr357	68	38	;	;	:
cord-017585-0llgr357	68	39	Raousseau	Raousseau	NNP
cord-017585-0llgr357	68	40	et	et	NNP
cord-017585-0llgr357	68	41	al	al	NNP
cord-017585-0llgr357	68	42	1995	1995	CD
cord-017585-0llgr357	68	43	)	)	-RRB-
cord-017585-0llgr357	68	44	.	.	.
cord-017585-0llgr357	69	1	Although	although	IN
cord-017585-0llgr357	69	2	current	current	JJ
cord-017585-0llgr357	69	3	evidence	evidence	NN
cord-017585-0llgr357	69	4	does	do	VBZ
cord-017585-0llgr357	69	5	not	not	RB
cord-017585-0llgr357	69	6	support	support	VB
cord-017585-0llgr357	69	7	a	a	DT
cord-017585-0llgr357	69	8	role	role	NN
cord-017585-0llgr357	69	9	for	for	IN
cord-017585-0llgr357	69	10	Ac	Ac	NNP
cord-017585-0llgr357	69	11	-	-	HYPH
cord-017585-0llgr357	69	12	SDKP	SDKP	NNP
cord-017585-0llgr357	69	13	in	in	IN
cord-017585-0llgr357	69	14	the	the	DT
cord-017585-0llgr357	69	15	regulation	regulation	NN
cord-017585-0llgr357	69	16	of	of	IN
cord-017585-0llgr357	69	17	blood	blood	NN
cord-017585-0llgr357	69	18	pressure	pressure	NN
cord-017585-0llgr357	69	19	,	,	,
cord-017585-0llgr357	69	20	the	the	DT
cord-017585-0llgr357	69	21	peptide	peptide	NN
cord-017585-0llgr357	69	22	does	do	VBZ
cord-017585-0llgr357	69	23	exhibit	exhibit	VB
cord-017585-0llgr357	69	24	potent	potent	JJ
cord-017585-0llgr357	69	25	anti	anti	JJ
cord-017585-0llgr357	69	26	-	-	JJ
cord-017585-0llgr357	69	27	fibrotic	fibrotic	JJ
cord-017585-0llgr357	69	28	and	and	CC
cord-017585-0llgr357	69	29	anti	anti	JJ
cord-017585-0llgr357	69	30	-	-	JJ
cord-017585-0llgr357	69	31	inflammatory	inflammatory	JJ
cord-017585-0llgr357	69	32	actions	action	NNS
cord-017585-0llgr357	70	1	(	(	-LRB-
cord-017585-0llgr357	70	2	Peng	Peng	NNP
cord-017585-0llgr357	70	3	et	et	NNP
cord-017585-0llgr357	70	4	al	al	NNP
cord-017585-0llgr357	70	5	2003	2003	CD
cord-017585-0llgr357	70	6	)	)	-RRB-
cord-017585-0llgr357	70	7	.	.	.
cord-017585-0llgr357	71	1	Indeed	indeed	RB
cord-017585-0llgr357	71	2	,	,	,
cord-017585-0llgr357	71	3	exogenous	exogenous	JJ
cord-017585-0llgr357	71	4	administration	administration	NN
cord-017585-0llgr357	71	5	of	of	IN
cord-017585-0llgr357	71	6	Ac	Ac	NNP
cord-017585-0llgr357	71	7	-	-	HYPH
cord-017585-0llgr357	71	8	SDKP	SDKP	NNP
cord-017585-0llgr357	71	9	attenuates	attenuate	VBZ
cord-017585-0llgr357	71	10	proteinuria	proteinuria	NN
cord-017585-0llgr357	71	11	and	and	CC
cord-017585-0llgr357	71	12	improves	improve	VBZ
cord-017585-0llgr357	71	13	renal	renal	JJ
cord-017585-0llgr357	71	14	function	function	NN
cord-017585-0llgr357	71	15	in	in	IN
cord-017585-0llgr357	71	16	several	several	JJ
cord-017585-0llgr357	71	17	models	model	NNS
cord-017585-0llgr357	71	18	of	of	IN
cord-017585-0llgr357	71	19	renal	renal	JJ
cord-017585-0llgr357	71	20	injury	injury	NN
cord-017585-0llgr357	71	21	and	and	CC
cord-017585-0llgr357	71	22	hypertension	hypertension	NN
cord-017585-0llgr357	72	1	(	(	-LRB-
cord-017585-0llgr357	72	2	Omata	Omata	NNP
cord-017585-0llgr357	72	3	et	et	NNP
cord-017585-0llgr357	72	4	al	al	NNP
cord-017585-0llgr357	72	5	2006	2006	CD
cord-017585-0llgr357	72	6	)	)	-RRB-
cord-017585-0llgr357	72	7	.	.	.
cord-017585-0llgr357	73	1	Interestingly	interestingly	RB
cord-017585-0llgr357	73	2	,	,	,
cord-017585-0llgr357	73	3	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	73	4	-	-	HYPH
cord-017585-0llgr357	73	5	7	7	CD
cord-017585-0llgr357	73	6	)	)	-RRB-
cord-017585-0llgr357	73	7	and	and	CC
cord-017585-0llgr357	73	8	Ac	Ac	NNP
cord-017585-0llgr357	73	9	-	-	HYPH
cord-017585-0llgr357	73	10	SDKP	SDKP	NNP
cord-017585-0llgr357	73	11	may	may	MD
cord-017585-0llgr357	73	12	be	be	VB
cord-017585-0llgr357	73	13	the	the	DT
cord-017585-0llgr357	73	14	only	only	RB
cord-017585-0llgr357	73	15	known	know	VBN
cord-017585-0llgr357	73	16	endogenous	endogenous	JJ
cord-017585-0llgr357	73	17	substrates	substrate	NNS
cord-017585-0llgr357	73	18	that	that	WDT
cord-017585-0llgr357	73	19	are	be	VBP
cord-017585-0llgr357	73	20	exclusively	exclusively	RB
cord-017585-0llgr357	73	21	cleaved	cleave	VBN
cord-017585-0llgr357	73	22	by	by	IN
cord-017585-0llgr357	73	23	the	the	DT
cord-017585-0llgr357	73	24	N	n	CD
cord-017585-0llgr357	73	25	-	-	HYPH
cord-017585-0llgr357	73	26	terminal	terminal	JJ
cord-017585-0llgr357	73	27	catalytic	catalytic	JJ
cord-017585-0llgr357	73	28	domain	domain	NN
cord-017585-0llgr357	73	29	of	of	IN
cord-017585-0llgr357	73	30	human	human	JJ
cord-017585-0llgr357	73	31	ACE	ace	NN
cord-017585-0llgr357	74	1	(	(	-LRB-
cord-017585-0llgr357	74	2	Raousseau	Raousseau	NNP
cord-017585-0llgr357	74	3	et	et	NNP
cord-017585-0llgr357	74	4	al	al	NNP
cord-017585-0llgr357	74	5	1995	1995	CD
cord-017585-0llgr357	74	6	;	;	:
cord-017585-0llgr357	74	7	Deddish	Deddish	NNP
cord-017585-0llgr357	74	8	et	et	NNP
cord-017585-0llgr357	74	9	al	al	NNP
cord-017585-0llgr357	74	10	1998	1998	CD
cord-017585-0llgr357	74	11	)	)	-RRB-
cord-017585-0llgr357	74	12	.	.	.
cord-017585-0llgr357	75	1	Moreover	moreover	RB
cord-017585-0llgr357	75	2	,	,	,
cord-017585-0llgr357	75	3	prolyl	prolyl	FW
cord-017585-0llgr357	75	4	(	(	-LRB-
cord-017585-0llgr357	75	5	oligo)endopeptidase	oligo)endopeptidase	NNP
cord-017585-0llgr357	75	6	,	,	,
cord-017585-0llgr357	75	7	an	an	DT
cord-017585-0llgr357	75	8	enzyme	enzyme	NN
cord-017585-0llgr357	75	9	that	that	WDT
cord-017585-0llgr357	75	10	processes	process	VBZ
cord-017585-0llgr357	75	11	Ang	Ang	NNP
cord-017585-0llgr357	75	12	I	I	NNP
cord-017585-0llgr357	75	13	or	or	CC
cord-017585-0llgr357	75	14	Ang	Ang	NNP
cord-017585-0llgr357	75	15	II	II	NNP
cord-017585-0llgr357	75	16	to	to	IN
cord-017585-0llgr357	75	17	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	75	18	-	-	HYPH
cord-017585-0llgr357	75	19	7	7	CD
cord-017585-0llgr357	75	20	)	)	-RRB-
cord-017585-0llgr357	75	21	in	in	IN
cord-017585-0llgr357	75	22	endothelial	endothelial	JJ
cord-017585-0llgr357	75	23	and	and	CC
cord-017585-0llgr357	75	24	neural	neural	JJ
cord-017585-0llgr357	75	25	cells	cell	NNS
cord-017585-0llgr357	75	26	(	(	-LRB-
cord-017585-0llgr357	75	27	Chappell	Chappell	NNP
cord-017585-0llgr357	75	28	et	et	NNP
cord-017585-0llgr357	75	29	al	al	NNP
cord-017585-0llgr357	75	30	1990	1990	CD
cord-017585-0llgr357	75	31	;	;	:
cord-017585-0llgr357	75	32	Santos	Santos	NNP
cord-017585-0llgr357	75	33	et	et	NNP
cord-017585-0llgr357	75	34	al	al	NNP
cord-017585-0llgr357	75	35	1992	1992	CD
cord-017585-0llgr357	75	36	)	)	-RRB-
cord-017585-0llgr357	75	37	,	,	,
cord-017585-0llgr357	75	38	may	may	MD
cord-017585-0llgr357	75	39	also	also	RB
cord-017585-0llgr357	75	40	convert	convert	VB
cord-017585-0llgr357	75	41	thymosin-2	thymosin-2	PRP
cord-017585-0llgr357	75	42	to	to	IN
cord-017585-0llgr357	75	43	Ac	Ac	NNP
cord-017585-0llgr357	75	44	-	-	HYPH
cord-017585-0llgr357	75	45	SDKP	SDKP	NNP
cord-017585-0llgr357	75	46	in	in	IN
cord-017585-0llgr357	75	47	plasma	plasma	NN
cord-017585-0llgr357	75	48	and	and	CC
cord-017585-0llgr357	75	49	tissue	tissue	NN
cord-017585-0llgr357	76	1	(	(	-LRB-
cord-017585-0llgr357	76	2	Cavasin	Cavasin	NNP
cord-017585-0llgr357	76	3	et	et	NNP
cord-017585-0llgr357	76	4	al	al	NNP
cord-017585-0llgr357	76	5	2004	2004	CD
cord-017585-0llgr357	76	6	)	)	-RRB-
cord-017585-0llgr357	76	7	.	.	.
cord-017585-0llgr357	77	1	The	the	DT
cord-017585-0llgr357	77	2	unusual	unusual	JJ
cord-017585-0llgr357	77	3	specificity	specificity	NN
cord-017585-0llgr357	77	4	of	of	IN
cord-017585-0llgr357	77	5	the	the	DT
cord-017585-0llgr357	77	6	N	n	CD
cord-017585-0llgr357	77	7	-	-	HYPH
cord-017585-0llgr357	77	8	domain	domain	NN
cord-017585-0llgr357	77	9	of	of	IN
cord-017585-0llgr357	77	10	ACE	ace	NN
cord-017585-0llgr357	77	11	for	for	IN
cord-017585-0llgr357	77	12	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	77	13	-	-	HYPH
cord-017585-0llgr357	77	14	7	7	CD
cord-017585-0llgr357	77	15	)	)	-RRB-
cord-017585-0llgr357	77	16	and	and	CC
cord-017585-0llgr357	77	17	Ac	Ac	NNP
cord-017585-0llgr357	77	18	-	-	HYPH
cord-017585-0llgr357	77	19	SDKP	SDKP	NNP
cord-017585-0llgr357	77	20	suggests	suggest	VBZ
cord-017585-0llgr357	77	21	an	an	DT
cord-017585-0llgr357	77	22	overlap	overlap	NN
cord-017585-0llgr357	77	23	of	of	IN
cord-017585-0llgr357	77	24	the	the	DT
cord-017585-0llgr357	77	25	activities	activity	NNS
cord-017585-0llgr357	77	26	of	of	IN
cord-017585-0llgr357	77	27	these	these	DT
cord-017585-0llgr357	77	28	two	two	CD
cord-017585-0llgr357	77	29	peptide	peptide	NN
cord-017585-0llgr357	77	30	systems	system	NNS
cord-017585-0llgr357	77	31	within	within	IN
cord-017585-0llgr357	77	32	the	the	DT
cord-017585-0llgr357	77	33	kidney	kidney	NN
cord-017585-0llgr357	77	34	as	as	RB
cord-017585-0llgr357	77	35	well	well	RB
cord-017585-0llgr357	77	36	.	.	.
cord-017585-0llgr357	78	1	Although	although	IN
cord-017585-0llgr357	78	2	elucidation	elucidation	NN
cord-017585-0llgr357	78	3	of	of	IN
cord-017585-0llgr357	78	4	the	the	DT
cord-017585-0llgr357	78	5	signaling	signal	VBG
cord-017585-0llgr357	78	6	mechanisms	mechanism	NNS
cord-017585-0llgr357	78	7	and	and	CC
cord-017585-0llgr357	78	8	receptors	receptor	NNS
cord-017585-0llgr357	78	9	for	for	IN
cord-017585-0llgr357	78	10	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	78	11	-	-	HYPH
cord-017585-0llgr357	78	12	7	7	CD
cord-017585-0llgr357	78	13	)	)	-RRB-
cord-017585-0llgr357	78	14	and	and	CC
cord-017585-0llgr357	78	15	Ac	Ac	NNP
cord-017585-0llgr357	78	16	-	-	HYPH
cord-017585-0llgr357	78	17	SDKP	SDKP	NNP
cord-017585-0llgr357	78	18	is	be	VBZ
cord-017585-0llgr357	78	19	at	at	IN
cord-017585-0llgr357	78	20	an	an	DT
cord-017585-0llgr357	78	21	early	early	JJ
cord-017585-0llgr357	78	22	stage	stage	NN
cord-017585-0llgr357	78	23	,	,	,
cord-017585-0llgr357	78	24	future	future	JJ
cord-017585-0llgr357	78	25	studies	study	NNS
cord-017585-0llgr357	78	26	should	should	MD
cord-017585-0llgr357	78	27	consider	consider	VB
cord-017585-0llgr357	78	28	whether	whether	IN
cord-017585-0llgr357	78	29	there	there	EX
cord-017585-0llgr357	78	30	is	be	VBZ
cord-017585-0llgr357	78	31	a	a	DT
cord-017585-0llgr357	78	32	basis	basis	NN
cord-017585-0llgr357	78	33	for	for	IN
cord-017585-0llgr357	78	34	the	the	DT
cord-017585-0llgr357	78	35	functional	functional	JJ
cord-017585-0llgr357	78	36	similarities	similarity	NNS
cord-017585-0llgr357	78	37	between	between	IN
cord-017585-0llgr357	78	38	these	these	DT
cord-017585-0llgr357	78	39	peptides	peptide	NNS
cord-017585-0llgr357	78	40	.	.	.
cord-017585-0llgr357	79	1	The	the	DT
cord-017585-0llgr357	79	2	role	role	NN
cord-017585-0llgr357	79	3	of	of	IN
cord-017585-0llgr357	79	4	RAAS	RAAS	NNP
cord-017585-0llgr357	79	5	enzymes	enzyme	NNS
cord-017585-0llgr357	79	6	including	include	VBG
cord-017585-0llgr357	79	7	ACE	ace	NN
cord-017585-0llgr357	79	8	and	and	CC
cord-017585-0llgr357	79	9	renin	renin	NN
cord-017585-0llgr357	79	10	has	have	VBZ
cord-017585-0llgr357	79	11	been	be	VBN
cord-017585-0llgr357	79	12	primarily	primarily	RB
cord-017585-0llgr357	79	13	emphasized	emphasize	VBN
cord-017585-0llgr357	79	14	for	for	IN
cord-017585-0llgr357	79	15	their	-PRON-	PRP$
cord-017585-0llgr357	79	16	catalytic	catalytic	JJ
cord-017585-0llgr357	79	17	properties	property	NNS
cord-017585-0llgr357	79	18	;	;	:
cord-017585-0llgr357	79	19	however	however	RB
cord-017585-0llgr357	79	20	,	,	,
cord-017585-0llgr357	79	21	compelling	compelling	JJ
cord-017585-0llgr357	79	22	evidence	evidence	NN
cord-017585-0llgr357	79	23	now	now	RB
cord-017585-0llgr357	79	24	reveals	reveal	VBZ
cord-017585-0llgr357	79	25	receptor	receptor	NN
cord-017585-0llgr357	79	26	-	-	HYPH
cord-017585-0llgr357	79	27	like	like	JJ
cord-017585-0llgr357	79	28	properties	property	NNS
cord-017585-0llgr357	79	29	for	for	IN
cord-017585-0llgr357	79	30	these	these	DT
cord-017585-0llgr357	79	31	two	two	CD
cord-017585-0llgr357	79	32	enzymes	enzyme	NNS
cord-017585-0llgr357	79	33	.	.	.
cord-017585-0llgr357	80	1	Indeed	indeed	RB
cord-017585-0llgr357	80	2	,	,	,
cord-017585-0llgr357	80	3	a	a	DT
cord-017585-0llgr357	80	4	renin	renin	NN
cord-017585-0llgr357	80	5	receptor	receptor	NN
cord-017585-0llgr357	80	6	was	be	VBD
cord-017585-0llgr357	80	7	recently	recently	RB
cord-017585-0llgr357	80	8	cloned	clone	VBN
cord-017585-0llgr357	80	9	by	by	IN
cord-017585-0llgr357	80	10	Nyguen	Nyguen	NNP
cord-017585-0llgr357	80	11	and	and	CC
cord-017585-0llgr357	80	12	colleagues	colleague	NNS
cord-017585-0llgr357	80	13	with	with	IN
cord-017585-0llgr357	80	14	significant	significant	JJ
cord-017585-0llgr357	80	15	concentrations	concentration	NNS
cord-017585-0llgr357	80	16	of	of	IN
cord-017585-0llgr357	80	17	the	the	DT
cord-017585-0llgr357	80	18	protein	protein	NN
cord-017585-0llgr357	80	19	in	in	IN
cord-017585-0llgr357	80	20	the	the	DT
cord-017585-0llgr357	80	21	glomerulus	glomerulus	NN
cord-017585-0llgr357	80	22	and	and	CC
cord-017585-0llgr357	80	23	vascular	vascular	JJ
cord-017585-0llgr357	80	24	smooth	smooth	JJ
cord-017585-0llgr357	80	25	muscle	muscle	NN
cord-017585-0llgr357	80	26	cells	cell	NNS
cord-017585-0llgr357	80	27	.	.	.
cord-017585-0llgr357	81	1	(	(	-LRB-
cord-017585-0llgr357	81	2	Diez	Diez	NNP
cord-017585-0llgr357	81	3	-	-	HYPH
cord-017585-0llgr357	81	4	Freire	Freire	NNP
cord-017585-0llgr357	81	5	et	et	NNP
cord-017585-0llgr357	81	6	al	al	NNP
cord-017585-0llgr357	81	7	2006	2006	CD
cord-017585-0llgr357	81	8	;	;	:
cord-017585-0llgr357	81	9	Nguyen	Nguyen	NNP
cord-017585-0llgr357	81	10	et	et	NNP
cord-017585-0llgr357	81	11	al	al	NNP
cord-017585-0llgr357	81	12	2002	2002	CD
cord-017585-0llgr357	81	13	)	)	-RRB-
cord-017585-0llgr357	81	14	.	.	.
cord-017585-0llgr357	82	1	Receptor	receptor	NN
cord-017585-0llgr357	82	2	-	-	HYPH
cord-017585-0llgr357	82	3	bound	bind	VBN
cord-017585-0llgr357	82	4	renin	renin	NN
cord-017585-0llgr357	82	5	exhibits	exhibit	NNS
cord-017585-0llgr357	82	6	increase	increase	NN
cord-017585-0llgr357	82	7	proteolyitc	proteolyitc	NN
cord-017585-0llgr357	82	8	activity	activity	NN
cord-017585-0llgr357	82	9	for	for	IN
cord-017585-0llgr357	82	10	Ang	Ang	NNP
cord-017585-0llgr357	82	11	I	I	NNP
cord-017585-0llgr357	82	12	formation	formation	NN
cord-017585-0llgr357	82	13	,	,	,
cord-017585-0llgr357	82	14	but	but	CC
cord-017585-0llgr357	82	15	both	both	DT
cord-017585-0llgr357	82	16	pro	pro	JJ
cord-017585-0llgr357	82	17	-	-	JJ
cord-017585-0llgr357	82	18	renin	renin	JJ
cord-017585-0llgr357	82	19	and	and	CC
cord-017585-0llgr357	82	20	renin	renin	NN
cord-017585-0llgr357	82	21	also	also	RB
cord-017585-0llgr357	82	22	induce	induce	VBP
cord-017585-0llgr357	82	23	distinct	distinct	JJ
cord-017585-0llgr357	82	24	signaling	signal	VBG
cord-017585-0llgr357	82	25	pathways	pathway	NNS
cord-017585-0llgr357	82	26	following	follow	VBG
cord-017585-0llgr357	82	27	binding	bind	VBG
cord-017585-0llgr357	82	28	.	.	.
cord-017585-0llgr357	83	1	In	in	IN
cord-017585-0llgr357	83	2	isolated	isolate	VBN
cord-017585-0llgr357	83	3	mesangial	mesangial	JJ
cord-017585-0llgr357	83	4	cells	cell	NNS
cord-017585-0llgr357	83	5	,	,	,
cord-017585-0llgr357	83	6	exogenous	exogenous	JJ
cord-017585-0llgr357	83	7	renin	renin	NN
cord-017585-0llgr357	83	8	increased	increase	VBN
cord-017585-0llgr357	83	9	TGF	TGF	NNP
cord-017585-0llgr357	83	10	-	-	HYPH
cord-017585-0llgr357	83	11	expression	expression	NN
cord-017585-0llgr357	83	12	and	and	CC
cord-017585-0llgr357	83	13	other	other	JJ
cord-017585-0llgr357	83	14	matrix	matrix	NN
cord-017585-0llgr357	83	15	proteins	protein	NNS
cord-017585-0llgr357	83	16	including	include	VBG
cord-017585-0llgr357	83	17	plasminogen	plasminogen	NN
cord-017585-0llgr357	83	18	activator	activator	NN
cord-017585-0llgr357	83	19	inhibitor	inhibitor	NN
cord-017585-0llgr357	83	20	(	(	-LRB-
cord-017585-0llgr357	83	21	PAI-1	PAI-1	NNP
cord-017585-0llgr357	83	22	)	)	-RRB-
cord-017585-0llgr357	83	23	and	and	CC
cord-017585-0llgr357	83	24	fibronectin	fibronectin	NN
cord-017585-0llgr357	83	25	that	that	WDT
cord-017585-0llgr357	83	26	was	be	VBD
cord-017585-0llgr357	83	27	apparently	apparently	RB
cord-017585-0llgr357	83	28	independent	independent	JJ
cord-017585-0llgr357	83	29	of	of	IN
cord-017585-0llgr357	83	30	Ang	Ang	NNP
cord-017585-0llgr357	83	31	II	II	NNP
cord-017585-0llgr357	83	32	synthesis	synthesis	NN
cord-017585-0llgr357	84	1	(	(	-LRB-
cord-017585-0llgr357	84	2	Huang	Huang	NNP
cord-017585-0llgr357	84	3	et	et	NNP
cord-017585-0llgr357	84	4	al	al	NNP
cord-017585-0llgr357	84	5	2006	2006	CD
cord-017585-0llgr357	84	6	)	)	-RRB-
cord-017585-0llgr357	84	7	.	.	.
cord-017585-0llgr357	85	1	ACE	ACE	NNP
cord-017585-0llgr357	85	2	inhibitors	inhibitor	NNS
cord-017585-0llgr357	85	3	may	may	MD
cord-017585-0llgr357	85	4	also	also	RB
cord-017585-0llgr357	85	5	induce	induce	VB
cord-017585-0llgr357	85	6	cell	cell	NN
cord-017585-0llgr357	85	7	-	-	HYPH
cord-017585-0llgr357	85	8	specific	specific	JJ
cord-017585-0llgr357	85	9	signaling	signaling	NN
cord-017585-0llgr357	85	10	by	by	IN
cord-017585-0llgr357	85	11	inducing	induce	VBG
cord-017585-0llgr357	85	12	conformational	conformational	JJ
cord-017585-0llgr357	85	13	changes	change	NNS
cord-017585-0llgr357	85	14	in	in	IN
cord-017585-0llgr357	85	15	membrane	membrane	NN
cord-017585-0llgr357	85	16	-	-	HYPH
cord-017585-0llgr357	85	17	bound	bind	VBN
cord-017585-0llgr357	85	18	ACE	ace	NN
cord-017585-0llgr357	85	19	without	without	IN
cord-017585-0llgr357	85	20	alterations	alteration	NNS
cord-017585-0llgr357	85	21	in	in	IN
cord-017585-0llgr357	85	22	Ang	Ang	NNP
cord-017585-0llgr357	85	23	II	II	NNP
cord-017585-0llgr357	85	24	or	or	CC
cord-017585-0llgr357	85	25	other	other	JJ
cord-017585-0llgr357	85	26	peptides	peptide	NNS
cord-017585-0llgr357	86	1	(	(	-LRB-
cord-017585-0llgr357	86	2	Benzing	Benzing	NNP
cord-017585-0llgr357	86	3	et	et	FW
cord-017585-0llgr357	86	4	al	al	NNP
cord-017585-0llgr357	86	5	1999	1999	CD
cord-017585-0llgr357	86	6	)	)	-RRB-
cord-017585-0llgr357	86	7	.	.	.
cord-017585-0llgr357	87	1	Two	two	CD
cord-017585-0llgr357	87	2	kinases	kinase	NNS
cord-017585-0llgr357	87	3	,	,	,
cord-017585-0llgr357	87	4	c	c	NN
cord-017585-0llgr357	87	5	-	-	:
cord-017585-0llgr357	87	6	Jun	Jun	NNP
cord-017585-0llgr357	87	7	kinase	kinase	NN
cord-017585-0llgr357	87	8	and	and	CC
cord-017585-0llgr357	87	9	MAP	MAP	NNP
cord-017585-0llgr357	87	10	kinase	kinase	NN
cord-017585-0llgr357	87	11	kinase	kinase	VBD
cord-017585-0llgr357	87	12	7	7	CD
cord-017585-0llgr357	87	13	associate	associate	NN
cord-017585-0llgr357	87	14	with	with	IN
cord-017585-0llgr357	87	15	the	the	DT
cord-017585-0llgr357	87	16	intracellular	intracellular	JJ
cord-017585-0llgr357	87	17	portion	portion	NN
cord-017585-0llgr357	87	18	of	of	IN
cord-017585-0llgr357	87	19	ACE	ace	NN
cord-017585-0llgr357	87	20	.	.	.
cord-017585-0llgr357	88	1	Moreover	moreover	RB
cord-017585-0llgr357	88	2	,	,	,
cord-017585-0llgr357	88	3	ACE	ACE	NNP
cord-017585-0llgr357	88	4	inhibitors	inhibitor	NNS
cord-017585-0llgr357	88	5	increase	increase	VBP
cord-017585-0llgr357	88	6	the	the	DT
cord-017585-0llgr357	88	7	phosphorylation	phosphorylation	NN
cord-017585-0llgr357	88	8	and	and	CC
cord-017585-0llgr357	88	9	nuclear	nuclear	JJ
cord-017585-0llgr357	88	10	trafficking	trafficking	NN
cord-017585-0llgr357	88	11	of	of	IN
cord-017585-0llgr357	88	12	phosphorylated	phosphorylated	JJ
cord-017585-0llgr357	88	13	cJun	cjun	JJ
cord-017585-0llgr357	88	14	kinase	kinase	NN
cord-017585-0llgr357	88	15	(	(	-LRB-
cord-017585-0llgr357	88	16	Kohlstedt	Kohlstedt	NNP
cord-017585-0llgr357	88	17	et	et	NNP
cord-017585-0llgr357	88	18	al	al	NNP
cord-017585-0llgr357	88	19	2002	2002	CD
cord-017585-0llgr357	88	20	)	)	-RRB-
cord-017585-0llgr357	88	21	.	.	.
cord-017585-0llgr357	89	1	This	this	DT
cord-017585-0llgr357	89	2	aspect	aspect	NN
cord-017585-0llgr357	89	3	of	of	IN
cord-017585-0llgr357	89	4	ACE	ace	NN
cord-017585-0llgr357	89	5	-	-	HYPH
cord-017585-0llgr357	89	6	dependent	dependent	JJ
cord-017585-0llgr357	89	7	activation	activation	NN
cord-017585-0llgr357	89	8	of	of	IN
cord-017585-0llgr357	89	9	various	various	JJ
cord-017585-0llgr357	89	10	kinases	kinase	NNS
cord-017585-0llgr357	89	11	has	have	VBZ
cord-017585-0llgr357	89	12	been	be	VBN
cord-017585-0llgr357	89	13	demonstrated	demonstrate	VBN
cord-017585-0llgr357	89	14	in	in	IN
cord-017585-0llgr357	89	15	human	human	JJ
cord-017585-0llgr357	89	16	endothelial	endothelial	JJ
cord-017585-0llgr357	89	17	cells	cell	NNS
cord-017585-0llgr357	89	18	and	and	CC
cord-017585-0llgr357	89	19	the	the	DT
cord-017585-0llgr357	89	20	question	question	NN
cord-017585-0llgr357	89	21	remains	remain	VBZ
cord-017585-0llgr357	89	22	as	as	IN
cord-017585-0llgr357	89	23	to	to	IN
cord-017585-0llgr357	89	24	what	what	WDT
cord-017585-0llgr357	89	25	extent	extent	NN
cord-017585-0llgr357	89	26	this	this	DT
cord-017585-0llgr357	89	27	occurs	occur	VBZ
cord-017585-0llgr357	89	28	in	in	IN
cord-017585-0llgr357	89	29	other	other	JJ
cord-017585-0llgr357	89	30	cells	cell	NNS
cord-017585-0llgr357	89	31	or	or	CC
cord-017585-0llgr357	89	32	tissues	tissue	NNS
cord-017585-0llgr357	89	33	.	.	.
cord-017585-0llgr357	90	1	In	in	IN
cord-017585-0llgr357	90	2	addition	addition	NN
cord-017585-0llgr357	90	3	,	,	,
cord-017585-0llgr357	90	4	ACE	ACE	NNP
cord-017585-0llgr357	90	5	inhibitors	inhibitor	NNS
cord-017585-0llgr357	90	6	or	or	CC
cord-017585-0llgr357	90	7	the	the	DT
cord-017585-0llgr357	90	8	angiotensin	angiotensin	NN
cord-017585-0llgr357	90	9	peptides	peptide	NNS
cord-017585-0llgr357	90	10	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	90	11	-	-	HYPH
cord-017585-0llgr357	90	12	9	9	CD
cord-017585-0llgr357	90	13	)	)	-RRB-
cord-017585-0llgr357	90	14	and	and	CC
cord-017585-0llgr357	90	15	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	90	16	-	-	HYPH
cord-017585-0llgr357	90	17	7	7	CD
cord-017585-0llgr357	90	18	)	)	-RRB-
cord-017585-0llgr357	90	19	induce	induce	VB
cord-017585-0llgr357	90	20	the	the	DT
cord-017585-0llgr357	90	21	association	association	NN
cord-017585-0llgr357	90	22	of	of	IN
cord-017585-0llgr357	90	23	ACE	ACE	NNP
cord-017585-0llgr357	90	24	and	and	CC
cord-017585-0llgr357	90	25	the	the	DT
cord-017585-0llgr357	90	26	bradykinin	bradykinin	NN
cord-017585-0llgr357	90	27	B2	b2	NN
cord-017585-0llgr357	90	28	receptor	receptor	NN
cord-017585-0llgr357	90	29	that	that	WDT
cord-017585-0llgr357	90	30	prevents	prevent	VBZ
cord-017585-0llgr357	90	31	the	the	DT
cord-017585-0llgr357	90	32	rapid	rapid	JJ
cord-017585-0llgr357	90	33	down	down	NN
cord-017585-0llgr357	90	34	-	-	HYPH
cord-017585-0llgr357	90	35	regulation	regulation	NN
cord-017585-0llgr357	90	36	of	of	IN
cord-017585-0llgr357	90	37	the	the	DT
cord-017585-0llgr357	90	38	ligand	ligand	NN
cord-017585-0llgr357	90	39	-	-	HYPH
cord-017585-0llgr357	90	40	receptor	receptor	NN
cord-017585-0llgr357	90	41	complex	complex	NN
cord-017585-0llgr357	90	42	,	,	,
cord-017585-0llgr357	90	43	thus	thus	RB
cord-017585-0llgr357	90	44	potentiating	potentiate	VBG
cord-017585-0llgr357	90	45	the	the	DT
cord-017585-0llgr357	90	46	actions	action	NNS
cord-017585-0llgr357	90	47	of	of	IN
cord-017585-0llgr357	90	48	bradykinin	bradykinin	NN
cord-017585-0llgr357	90	49	(	(	-LRB-
cord-017585-0llgr357	90	50	Burckle	Burckle	NNP
cord-017585-0llgr357	90	51	et	et	NNP
cord-017585-0llgr357	90	52	al	al	NNP
cord-017585-0llgr357	90	53	2006	2006	CD
cord-017585-0llgr357	90	54	;	;	:
cord-017585-0llgr357	90	55	Chen	Chen	NNP
cord-017585-0llgr357	90	56	et	et	NNP
cord-017585-0llgr357	90	57	al	al	NNP
cord-017585-0llgr357	90	58	2005	2005	CD
cord-017585-0llgr357	90	59	)	)	-RRB-
cord-017585-0llgr357	90	60	.	.	.
cord-017585-0llgr357	91	1	Almost	almost	RB
cord-017585-0llgr357	91	2	50	50	CD
cord-017585-0llgr357	91	3	years	year	NNS
cord-017585-0llgr357	91	4	following	follow	VBG
cord-017585-0llgr357	91	5	the	the	DT
cord-017585-0llgr357	91	6	discovery	discovery	NN
cord-017585-0llgr357	91	7	of	of	IN
cord-017585-0llgr357	91	8	ACE	ACE	NNP
cord-017585-0llgr357	91	9	,	,	,
cord-017585-0llgr357	91	10	a	a	DT
cord-017585-0llgr357	91	11	new	new	JJ
cord-017585-0llgr357	91	12	homolog	homolog	NN
cord-017585-0llgr357	91	13	of	of	IN
cord-017585-0llgr357	91	14	the	the	DT
cord-017585-0llgr357	91	15	enzyme	enzyme	NN
cord-017585-0llgr357	91	16	termed	term	VBN
cord-017585-0llgr357	91	17	ACE2	ACE2	NNP
cord-017585-0llgr357	91	18	was	be	VBD
cord-017585-0llgr357	91	19	identified	identify	VBN
cord-017585-0llgr357	91	20	by	by	IN
cord-017585-0llgr357	91	21	two	two	CD
cord-017585-0llgr357	91	22	separate	separate	JJ
cord-017585-0llgr357	91	23	groups	group	NNS
cord-017585-0llgr357	91	24	(	(	-LRB-
cord-017585-0llgr357	91	25	Donoghue	Donoghue	NNP
cord-017585-0llgr357	91	26	et	et	NNP
cord-017585-0llgr357	91	27	al	al	NNP
cord-017585-0llgr357	91	28	2000	2000	CD
cord-017585-0llgr357	91	29	;	;	:
cord-017585-0llgr357	91	30	Tipnis	Tipnis	NNP
cord-017585-0llgr357	91	31	et	et	NNP
cord-017585-0llgr357	91	32	al	al	NNP
cord-017585-0llgr357	91	33	2000	2000	CD
cord-017585-0llgr357	91	34	)	)	-RRB-
cord-017585-0llgr357	91	35	.	.	.
cord-017585-0llgr357	92	1	ACE2	ace2	NN
cord-017585-0llgr357	92	2	activity	activity	NN
cord-017585-0llgr357	92	3	is	be	VBZ
cord-017585-0llgr357	92	4	not	not	RB
cord-017585-0llgr357	92	5	attenuated	attenuate	VBN
cord-017585-0llgr357	92	6	by	by	IN
cord-017585-0llgr357	92	7	ACE	ACE	NNP
cord-017585-0llgr357	92	8	inhibitors	inhibitor	NNS
cord-017585-0llgr357	92	9	nor	nor	CC
cord-017585-0llgr357	92	10	does	do	VBZ
cord-017585-0llgr357	92	11	the	the	DT
cord-017585-0llgr357	92	12	enzyme	enzyme	NN
cord-017585-0llgr357	92	13	share	share	VB
cord-017585-0llgr357	92	14	the	the	DT
cord-017585-0llgr357	92	15	same	same	JJ
cord-017585-0llgr357	92	16	catalytic	catalytic	JJ
cord-017585-0llgr357	92	17	properties	property	NNS
cord-017585-0llgr357	92	18	.	.	.
cord-017585-0llgr357	93	1	In	in	IN
cord-017585-0llgr357	93	2	this	this	DT
cord-017585-0llgr357	93	3	regard	regard	NN
cord-017585-0llgr357	93	4	,	,	,
cord-017585-0llgr357	93	5	ACE2	ACE2	NNP
cord-017585-0llgr357	93	6	contains	contain	VBZ
cord-017585-0llgr357	93	7	a	a	DT
cord-017585-0llgr357	93	8	single	single	JJ
cord-017585-0llgr357	93	9	zincdependent	zincdependent	NN
cord-017585-0llgr357	93	10	catalytic	catalytic	NN
cord-017585-0llgr357	93	11	site	site	NN
cord-017585-0llgr357	93	12	that	that	WDT
cord-017585-0llgr357	93	13	corresponds	correspond	VBZ
cord-017585-0llgr357	93	14	to	to	IN
cord-017585-0llgr357	93	15	the	the	DT
cord-017585-0llgr357	93	16	C	C	NNP
cord-017585-0llgr357	93	17	-	-	HYPH
cord-017585-0llgr357	93	18	terminal	terminal	NN
cord-017585-0llgr357	93	19	domain	domain	NN
cord-017585-0llgr357	93	20	of	of	IN
cord-017585-0llgr357	93	21	somatic	somatic	JJ
cord-017585-0llgr357	93	22	ACE	ace	NN
cord-017585-0llgr357	93	23	.	.	.
cord-017585-0llgr357	94	1	ACE2	ACE2	NNP
cord-017585-0llgr357	94	2	exhibits	exhibit	VBZ
cord-017585-0llgr357	94	3	carboxypeptidase	carboxypeptidase	NN
cord-017585-0llgr357	94	4	activity	activity	NN
cord-017585-0llgr357	94	5	cleaving	cleave	VBG
cord-017585-0llgr357	94	6	a	a	DT
cord-017585-0llgr357	94	7	single	single	JJ
cord-017585-0llgr357	94	8	amino	amino	NN
cord-017585-0llgr357	94	9	acid	acid	NN
cord-017585-0llgr357	94	10	residue	residue	NN
cord-017585-0llgr357	94	11	at	at	IN
cord-017585-0llgr357	94	12	the	the	DT
cord-017585-0llgr357	94	13	carboxyl	carboxyl	NN
cord-017585-0llgr357	94	14	terminus	terminus	NN
cord-017585-0llgr357	94	15	of	of	IN
cord-017585-0llgr357	94	16	various	various	JJ
cord-017585-0llgr357	94	17	peptides	peptide	NNS
cord-017585-0llgr357	94	18	.	.	.
cord-017585-0llgr357	95	1	The	the	DT
cord-017585-0llgr357	95	2	original	original	JJ
cord-017585-0llgr357	95	3	studies	study	NNS
cord-017585-0llgr357	95	4	assessed	assess	VBD
cord-017585-0llgr357	95	5	Ang	Ang	NNP
cord-017585-0llgr357	95	6	I	-PRON-	PRP
cord-017585-0llgr357	95	7	as	as	IN
cord-017585-0llgr357	95	8	the	the	DT
cord-017585-0llgr357	95	9	peptide	peptide	NN
cord-017585-0llgr357	95	10	substrate	substrate	NN
cord-017585-0llgr357	95	11	for	for	IN
cord-017585-0llgr357	95	12	ACE2	ACE2	NNP
cord-017585-0llgr357	95	13	,	,	,
cord-017585-0llgr357	95	14	given	give	VBN
cord-017585-0llgr357	95	15	the	the	DT
cord-017585-0llgr357	95	16	similar	similar	JJ
cord-017585-0llgr357	95	17	homology	homology	NN
cord-017585-0llgr357	95	18	to	to	IN
cord-017585-0llgr357	95	19	ACE	ace	NN
cord-017585-0llgr357	95	20	and	and	CC
cord-017585-0llgr357	95	21	the	the	DT
cord-017585-0llgr357	95	22	existing	exist	VBG
cord-017585-0llgr357	95	23	evidence	evidence	NN
cord-017585-0llgr357	95	24	for	for	IN
cord-017585-0llgr357	95	25	ACE	ace	NN
cord-017585-0llgr357	95	26	-	-	HYPH
cord-017585-0llgr357	95	27	independent	independent	JJ
cord-017585-0llgr357	95	28	pathways	pathway	NNS
cord-017585-0llgr357	95	29	;	;	:
cord-017585-0llgr357	95	30	however	however	RB
cord-017585-0llgr357	95	31	,	,	,
cord-017585-0llgr357	95	32	ACE2	ACE2	NNP
cord-017585-0llgr357	95	33	converted	convert	VBD
cord-017585-0llgr357	95	34	Ang	Ang	NNP
cord-017585-0llgr357	95	35	I	-PRON-	PRP
cord-017585-0llgr357	95	36	to	to	IN
cord-017585-0llgr357	95	37	the	the	DT
cord-017585-0llgr357	95	38	nonapeptide	nonapeptide	NN
cord-017585-0llgr357	95	39	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	95	40	-	-	HYPH
cord-017585-0llgr357	95	41	9	9	CD
cord-017585-0llgr357	95	42	)	)	-RRB-
cord-017585-0llgr357	96	1	(	(	-LRB-
cord-017585-0llgr357	96	2	Donoghue	Donoghue	NNP
cord-017585-0llgr357	96	3	et	et	NNP
cord-017585-0llgr357	96	4	al	al	NNP
cord-017585-0llgr357	96	5	2000	2000	CD
cord-017585-0llgr357	96	6	)	)	-RRB-
cord-017585-0llgr357	96	7	.	.	.
cord-017585-0llgr357	97	1	This	this	DT
cord-017585-0llgr357	97	2	product	product	NN
cord-017585-0llgr357	97	3	is	be	VBZ
cord-017585-0llgr357	97	4	currently	currently	RB
cord-017585-0llgr357	97	5	not	not	RB
cord-017585-0llgr357	97	6	known	know	VBN
cord-017585-0llgr357	97	7	to	to	TO
cord-017585-0llgr357	97	8	exhibit	exhibit	VB
cord-017585-0llgr357	97	9	functional	functional	JJ
cord-017585-0llgr357	97	10	activity	activity	NN
cord-017585-0llgr357	97	11	,	,	,
cord-017585-0llgr357	97	12	but	but	CC
cord-017585-0llgr357	97	13	may	may	MD
cord-017585-0llgr357	97	14	serve	serve	VB
cord-017585-0llgr357	97	15	as	as	IN
cord-017585-0llgr357	97	16	a	a	DT
cord-017585-0llgr357	97	17	substrate	substrate	NN
cord-017585-0llgr357	97	18	for	for	IN
cord-017585-0llgr357	97	19	the	the	DT
cord-017585-0llgr357	97	20	further	further	JJ
cord-017585-0llgr357	97	21	processing	processing	NN
cord-017585-0llgr357	97	22	to	to	IN
cord-017585-0llgr357	97	23	Ang	Ang	NNP
cord-017585-0llgr357	97	24	II	II	NNP
cord-017585-0llgr357	97	25	or	or	CC
cord-017585-0llgr357	97	26	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	97	27	-	-	HYPH
cord-017585-0llgr357	97	28	7	7	CD
cord-017585-0llgr357	97	29	)	)	-RRB-
cord-017585-0llgr357	97	30	.	.	.
cord-017585-0llgr357	98	1	The	the	DT
cord-017585-0llgr357	98	2	subsequent	subsequent	JJ
cord-017585-0llgr357	98	3	kinetic	kinetic	JJ
cord-017585-0llgr357	98	4	studies	study	NNS
cord-017585-0llgr357	98	5	of	of	IN
cord-017585-0llgr357	98	6	over	over	IN
cord-017585-0llgr357	98	7	120	120	CD
cord-017585-0llgr357	98	8	peptides	peptide	NNS
cord-017585-0llgr357	98	9	found	find	VBN
cord-017585-0llgr357	98	10	that	that	IN
cord-017585-0llgr357	98	11	the	the	DT
cord-017585-0llgr357	98	12	conversion	conversion	NN
cord-017585-0llgr357	98	13	of	of	IN
cord-017585-0llgr357	98	14	Ang	Ang	NNP
cord-017585-0llgr357	98	15	II	II	NNP
cord-017585-0llgr357	98	16	to	to	IN
cord-017585-0llgr357	98	17	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	98	18	-	-	HYPH
cord-017585-0llgr357	98	19	7	7	CD
cord-017585-0llgr357	98	20	)	)	-RRB-
cord-017585-0llgr357	98	21	was	be	VBD
cord-017585-0llgr357	98	22	much	much	RB
cord-017585-0llgr357	98	23	preferred	prefer	VBN
cord-017585-0llgr357	98	24	over	over	IN
cord-017585-0llgr357	98	25	that	that	DT
cord-017585-0llgr357	98	26	for	for	IN
cord-017585-0llgr357	98	27	Ang	Ang	NNP
cord-017585-0llgr357	98	28	I	I	NNP
cord-017585-0llgr357	99	1	(	(	-LRB-
cord-017585-0llgr357	99	2	Vickers	Vickers	NNP
cord-017585-0llgr357	99	3	et	et	NNP
cord-017585-0llgr357	99	4	al	al	NNP
cord-017585-0llgr357	99	5	2002	2002	CD
cord-017585-0llgr357	99	6	)	)	-RRB-
cord-017585-0llgr357	99	7	.	.	.
cord-017585-0llgr357	100	1	Indeed	indeed	RB
cord-017585-0llgr357	100	2	,	,	,
cord-017585-0llgr357	100	3	ACE2	ACE2	NNP
cord-017585-0llgr357	100	4	exhibits	exhibit	VBZ
cord-017585-0llgr357	100	5	an	an	DT
cord-017585-0llgr357	100	6	approximate	approximate	JJ
cord-017585-0llgr357	100	7	500-fold	500-fold	CD
cord-017585-0llgr357	100	8	greater	great	JJR
cord-017585-0llgr357	100	9	kcat	kcat	NNP
cord-017585-0llgr357	100	10	/	/	SYM
cord-017585-0llgr357	100	11	Km	Km	NNP
cord-017585-0llgr357	100	12	for	for	IN
cord-017585-0llgr357	100	13	Ang	Ang	NNP
cord-017585-0llgr357	100	14	II	II	NNP
cord-017585-0llgr357	100	15	versus	versus	IN
cord-017585-0llgr357	100	16	Ang	Ang	NNP
cord-017585-0llgr357	100	17	I	I	NNP
cord-017585-0llgr357	100	18	and	and	CC
cord-017585-0llgr357	100	19	has	have	VBZ
cord-017585-0llgr357	100	20	the	the	DT
cord-017585-0llgr357	100	21	highest	high	JJS
cord-017585-0llgr357	100	22	efficiency	efficiency	NN
cord-017585-0llgr357	100	23	among	among	IN
cord-017585-0llgr357	100	24	the	the	DT
cord-017585-0llgr357	100	25	known	know	VBN
cord-017585-0llgr357	100	26	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	100	27	-	-	HYPH
cord-017585-0llgr357	100	28	7)-forming	7)-forme	VBG
cord-017585-0llgr357	100	29	enzymes	enzyme	NNS
cord-017585-0llgr357	100	30	(	(	-LRB-
cord-017585-0llgr357	100	31	Fig	fig	NN
cord-017585-0llgr357	100	32	.	.	NNP
cord-017585-0llgr357	100	33	2	2	CD
cord-017585-0llgr357	100	34	)	)	-RRB-
cord-017585-0llgr357	100	35	.	.	.
cord-017585-0llgr357	101	1	These	these	DT
cord-017585-0llgr357	101	2	studies	study	NNS
cord-017585-0llgr357	101	3	also	also	RB
cord-017585-0llgr357	101	4	revealed	reveal	VBD
cord-017585-0llgr357	101	5	that	that	IN
cord-017585-0llgr357	101	6	other	other	JJ
cord-017585-0llgr357	101	7	peptides	peptide	NNS
cord-017585-0llgr357	101	8	including	include	VBG
cord-017585-0llgr357	101	9	apelin	apelin	NNP
cord-017585-0llgr357	101	10	13	13	CD
cord-017585-0llgr357	101	11	and	and	CC
cord-017585-0llgr357	101	12	dynorphin	dynorphin	NNP
cord-017585-0llgr357	101	13	are	be	VBP
cord-017585-0llgr357	101	14	cleaved	cleave	VBN
cord-017585-0llgr357	101	15	by	by	IN
cord-017585-0llgr357	101	16	ACE2	ACE2	NNP
cord-017585-0llgr357	101	17	at	at	IN
cord-017585-0llgr357	101	18	a	a	DT
cord-017585-0llgr357	101	19	similar	similar	JJ
cord-017585-0llgr357	101	20	or	or	CC
cord-017585-0llgr357	101	21	slightly	slightly	RB
cord-017585-0llgr357	101	22	greater	great	JJR
cord-017585-0llgr357	101	23	efficiency	efficiency	NN
cord-017585-0llgr357	101	24	than	than	IN
cord-017585-0llgr357	101	25	Ang	Ang	NNP
cord-017585-0llgr357	101	26	II	II	NNP
cord-017585-0llgr357	102	1	(	(	-LRB-
cord-017585-0llgr357	102	2	Vickers	Vickers	NNP
cord-017585-0llgr357	102	3	et	et	NNP
cord-017585-0llgr357	102	4	al	al	NNP
cord-017585-0llgr357	102	5	2002	2002	CD
cord-017585-0llgr357	102	6	)	)	-RRB-
cord-017585-0llgr357	102	7	.	.	.
cord-017585-0llgr357	103	1	At	at	IN
cord-017585-0llgr357	103	2	this	this	DT
cord-017585-0llgr357	103	3	time	time	NN
cord-017585-0llgr357	103	4	,	,	,
cord-017585-0llgr357	103	5	the	the	DT
cord-017585-0llgr357	103	6	majority	majority	NN
cord-017585-0llgr357	103	7	of	of	IN
cord-017585-0llgr357	103	8	studies	study	NNS
cord-017585-0llgr357	103	9	have	have	VBP
cord-017585-0llgr357	103	10	focused	focus	VBN
cord-017585-0llgr357	103	11	on	on	IN
cord-017585-0llgr357	103	12	the	the	DT
cord-017585-0llgr357	103	13	role	role	NN
cord-017585-0llgr357	103	14	of	of	IN
cord-017585-0llgr357	103	15	ACE2	ACE2	NNP
cord-017585-0llgr357	103	16	in	in	IN
cord-017585-0llgr357	103	17	the	the	DT
cord-017585-0llgr357	103	18	metabolism	metabolism	NN
cord-017585-0llgr357	103	19	of	of	IN
cord-017585-0llgr357	103	20	angiotensins	angiotensin	NNS
cord-017585-0llgr357	103	21	(	(	-LRB-
cord-017585-0llgr357	103	22	see	see	VB
cord-017585-0llgr357	103	23	below	below	RB
cord-017585-0llgr357	103	24	)	)	-RRB-
cord-017585-0llgr357	103	25	,	,	,
cord-017585-0llgr357	103	26	principally	principally	RB
cord-017585-0llgr357	103	27	Ang	Ang	NNP
cord-017585-0llgr357	103	28	II	II	NNP
cord-017585-0llgr357	103	29	to	to	IN
cord-017585-0llgr357	103	30	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	103	31	-	-	HYPH
cord-017585-0llgr357	103	32	7	7	CD
cord-017585-0llgr357	103	33	)	)	-RRB-
cord-017585-0llgr357	103	34	,	,	,
cord-017585-0llgr357	103	35	and	and	CC
cord-017585-0llgr357	103	36	the	the	DT
cord-017585-0llgr357	103	37	role	role	NN
cord-017585-0llgr357	103	38	of	of	IN
cord-017585-0llgr357	103	39	ACE2	ACE2	NNP
cord-017585-0llgr357	103	40	in	in	IN
cord-017585-0llgr357	103	41	the	the	DT
cord-017585-0llgr357	103	42	processing	processing	NN
cord-017585-0llgr357	103	43	of	of	IN
cord-017585-0llgr357	103	44	apelin	apelin	NN
cord-017585-0llgr357	103	45	or	or	CC
cord-017585-0llgr357	103	46	other	other	JJ
cord-017585-0llgr357	103	47	peptides	peptide	NNS
cord-017585-0llgr357	103	48	has	have	VBZ
cord-017585-0llgr357	103	49	not	not	RB
cord-017585-0llgr357	103	50	been	be	VBN
cord-017585-0llgr357	103	51	sufficiently	sufficiently	RB
cord-017585-0llgr357	103	52	addressed	address	VBN
cord-017585-0llgr357	103	53	.	.	.
cord-017585-0llgr357	104	1	Similar	similar	JJ
cord-017585-0llgr357	104	2	to	to	IN
cord-017585-0llgr357	104	3	ACE	ACE	NNP
cord-017585-0llgr357	104	4	,	,	,
cord-017585-0llgr357	104	5	ACE2	ACE2	NNP
cord-017585-0llgr357	104	6	exists	exist	VBZ
cord-017585-0llgr357	104	7	in	in	IN
cord-017585-0llgr357	104	8	both	both	CC
cord-017585-0llgr357	104	9	soluble	soluble	JJ
cord-017585-0llgr357	104	10	and	and	CC
cord-017585-0llgr357	104	11	membrane	membrane	NN
cord-017585-0llgr357	104	12	-	-	HYPH
cord-017585-0llgr357	104	13	associated	associate	VBN
cord-017585-0llgr357	104	14	forms	form	NNS
cord-017585-0llgr357	104	15	with	with	IN
cord-017585-0llgr357	104	16	high	high	JJ
cord-017585-0llgr357	104	17	expression	expression	NN
cord-017585-0llgr357	104	18	in	in	IN
cord-017585-0llgr357	104	19	the	the	DT
cord-017585-0llgr357	104	20	kidney	kidney	NN
cord-017585-0llgr357	104	21	,	,	,
cord-017585-0llgr357	104	22	heart	heart	NN
cord-017585-0llgr357	104	23	,	,	,
cord-017585-0llgr357	104	24	brain	brain	NN
cord-017585-0llgr357	104	25	,	,	,
cord-017585-0llgr357	104	26	lung	lung	NN
cord-017585-0llgr357	104	27	and	and	CC
cord-017585-0llgr357	104	28	testes	testis	NNS
cord-017585-0llgr357	104	29	(	(	-LRB-
cord-017585-0llgr357	104	30	Harmer	Harmer	NNP
cord-017585-0llgr357	104	31	et	et	NNP
cord-017585-0llgr357	104	32	al	al	NNP
cord-017585-0llgr357	104	33	2002	2002	CD
cord-017585-0llgr357	104	34	)	)	-RRB-
cord-017585-0llgr357	104	35	.	.	.
cord-017585-0llgr357	105	1	Although	although	IN
cord-017585-0llgr357	105	2	there	there	EX
cord-017585-0llgr357	105	3	is	be	VBZ
cord-017585-0llgr357	105	4	significant	significant	JJ
cord-017585-0llgr357	105	5	circulating	circulate	VBG
cord-017585-0llgr357	105	6	ACE	ace	NN
cord-017585-0llgr357	105	7	activity	activity	NN
cord-017585-0llgr357	105	8	in	in	IN
cord-017585-0llgr357	105	9	various	various	JJ
cord-017585-0llgr357	105	10	species	specie	NNS
cord-017585-0llgr357	105	11	,	,	,
cord-017585-0llgr357	105	12	plasma	plasma	NN
cord-017585-0llgr357	105	13	levels	level	NNS
cord-017585-0llgr357	105	14	of	of	IN
cord-017585-0llgr357	105	15	ACE2	ACE2	NNP
cord-017585-0llgr357	105	16	are	be	VBP
cord-017585-0llgr357	105	17	quite	quite	RB
cord-017585-0llgr357	105	18	low	low	JJ
cord-017585-0llgr357	105	19	,	,	,
cord-017585-0llgr357	105	20	but	but	CC
cord-017585-0llgr357	105	21	may	may	MD
cord-017585-0llgr357	105	22	vary	vary	VB
cord-017585-0llgr357	105	23	among	among	IN
cord-017585-0llgr357	105	24	species	specie	NNS
cord-017585-0llgr357	105	25	(	(	-LRB-
cord-017585-0llgr357	105	26	Elased	Elased	NNP
cord-017585-0llgr357	105	27	et	et	FW
cord-017585-0llgr357	105	28	al	al	NNP
cord-017585-0llgr357	105	29	2006	2006	CD
cord-017585-0llgr357	105	30	;	;	:
cord-017585-0llgr357	105	31	Rice	Rice	NNP
cord-017585-0llgr357	105	32	et	et	NNP
cord-017585-0llgr357	105	33	al	al	NNP
cord-017585-0llgr357	105	34	2006	2006	CD
cord-017585-0llgr357	105	35	)	)	-RRB-
cord-017585-0llgr357	105	36	.	.	.
cord-017585-0llgr357	106	1	Recent	recent	JJ
cord-017585-0llgr357	106	2	studies	study	NNS
cord-017585-0llgr357	106	3	in	in	IN
cord-017585-0llgr357	106	4	the	the	DT
cord-017585-0llgr357	106	5	sheep	sheep	NNS
cord-017585-0llgr357	106	6	reveal	reveal	VBP
cord-017585-0llgr357	106	7	appreciable	appreciable	JJ
cord-017585-0llgr357	106	8	ACE2	ACE2	NNP
cord-017585-0llgr357	106	9	in	in	IN
cord-017585-0llgr357	106	10	the	the	DT
cord-017585-0llgr357	106	11	plasma	plasma	NN
cord-017585-0llgr357	106	12	,	,	,
cord-017585-0llgr357	106	13	albeit	albeit	IN
cord-017585-0llgr357	106	14	the	the	DT
cord-017585-0llgr357	106	15	activity	activity	NN
cord-017585-0llgr357	106	16	was	be	VBD
cord-017585-0llgr357	106	17	significantly	significantly	RB
cord-017585-0llgr357	106	18	lower	low	JJR
cord-017585-0llgr357	106	19	than	than	IN
cord-017585-0llgr357	106	20	that	that	DT
cord-017585-0llgr357	106	21	for	for	IN
cord-017585-0llgr357	106	22	ACE	ace	NN
cord-017585-0llgr357	107	1	(	(	-LRB-
cord-017585-0llgr357	107	2	Fig	Fig	NNP
cord-017585-0llgr357	107	3	.	.	.
cord-017585-0llgr357	107	4	3	3	CD
cord-017585-0llgr357	107	5	,	,	,
cord-017585-0llgr357	107	6	inset	inset	NN
cord-017585-0llgr357	107	7	)	)	-RRB-
cord-017585-0llgr357	108	1	(	(	-LRB-
cord-017585-0llgr357	108	2	Shaltout	Shaltout	NNP
cord-017585-0llgr357	108	3	et	et	NNP
cord-017585-0llgr357	108	4	al	al	NNP
cord-017585-0llgr357	108	5	2007	2007	CD
cord-017585-0llgr357	108	6	)	)	-RRB-
cord-017585-0llgr357	108	7	.	.	.
cord-017585-0llgr357	109	1	For	for	IN
cord-017585-0llgr357	109	2	this	this	DT
cord-017585-0llgr357	109	3	assessment	assessment	NN
cord-017585-0llgr357	109	4	,	,	,
cord-017585-0llgr357	109	5	we	-PRON-	PRP
cord-017585-0llgr357	109	6	compared	compare	VBD
cord-017585-0llgr357	109	7	the	the	DT
cord-017585-0llgr357	109	8	enzyme	enzyme	NN
cord-017585-0llgr357	109	9	activities	activity	NNS
cord-017585-0llgr357	109	10	using	use	VBG
cord-017585-0llgr357	109	11	the	the	DT
cord-017585-0llgr357	109	12	endogenous	endogenous	JJ
cord-017585-0llgr357	109	13	substrates	substrate	NNS
cord-017585-0llgr357	109	14	for	for	IN
cord-017585-0llgr357	109	15	both	both	CC
cord-017585-0llgr357	109	16	ACE	ACE	NNP
cord-017585-0llgr357	109	17	and	and	CC
cord-017585-0llgr357	109	18	ACE2	ACE2	NNP
cord-017585-0llgr357	110	1	(	(	-LRB-
cord-017585-0llgr357	110	2	Ang	Ang	NNP
cord-017585-0llgr357	110	3	I	I	NNP
cord-017585-0llgr357	110	4	and	and	CC
cord-017585-0llgr357	110	5	Ang	Ang	NNP
cord-017585-0llgr357	110	6	II	II	NNP
cord-017585-0llgr357	110	7	,	,	,
cord-017585-0llgr357	110	8	respectively	respectively	RB
cord-017585-0llgr357	110	9	)	)	-RRB-
cord-017585-0llgr357	110	10	Data	datum	NNS
cord-017585-0llgr357	110	11	are	be	VBP
cord-017585-0llgr357	110	12	n	n	NN
cord-017585-0llgr357	110	13	=	=	SYM
cord-017585-0llgr357	110	14	4	4	CD
cord-017585-0llgr357	110	15	-	-	SYM
cord-017585-0llgr357	110	16	5	5	CD
cord-017585-0llgr357	110	17	,	,	,
cord-017585-0llgr357	111	1	mean	mean	VB
cord-017585-0llgr357	111	2	±	±	NNP
cord-017585-0llgr357	111	3	SEM	SEM	NNP
cord-017585-0llgr357	111	4	;	;	:
cord-017585-0llgr357	112	1	*	*	NFP
cord-017585-0llgr357	112	2	P	p	XX
cord-017585-0llgr357	112	3	<	<	XX
cord-017585-0llgr357	112	4	0.05	0.05	CD
cord-017585-0llgr357	112	5	vs.	vs.	CC
cord-017585-0llgr357	112	6	control	control	NN
cord-017585-0llgr357	112	7	at	at	IN
cord-017585-0llgr357	112	8	equimolar	equimolar	NNP
cord-017585-0llgr357	112	9	concentrations	concentration	NNS
cord-017585-0llgr357	112	10	under	under	IN
cord-017585-0llgr357	112	11	identical	identical	JJ
cord-017585-0llgr357	112	12	incubation	incubation	NN
cord-017585-0llgr357	112	13	conditions	condition	NNS
cord-017585-0llgr357	112	14	.	.	.
cord-017585-0llgr357	113	1	Interestingly	interestingly	RB
cord-017585-0llgr357	113	2	,	,	,
cord-017585-0llgr357	113	3	as	as	IN
cord-017585-0llgr357	113	4	shown	show	VBN
cord-017585-0llgr357	113	5	in	in	IN
cord-017585-0llgr357	113	6	Fig	Fig	NNP
cord-017585-0llgr357	113	7	.	.	.
cord-017585-0llgr357	114	1	3	3	CD
cord-017585-0llgr357	114	2	,	,	,
cord-017585-0llgr357	114	3	male	male	JJ
cord-017585-0llgr357	114	4	sheep	sheep	NNS
cord-017585-0llgr357	114	5	exhibited	exhibit	VBD
cord-017585-0llgr357	114	6	higher	high	JJR
cord-017585-0llgr357	114	7	ACE2	ACE2	NNP
cord-017585-0llgr357	114	8	activity	activity	NN
cord-017585-0llgr357	114	9	than	than	IN
cord-017585-0llgr357	114	10	females	female	NNS
cord-017585-0llgr357	114	11	that	that	WDT
cord-017585-0llgr357	114	12	likely	likely	RB
cord-017585-0llgr357	114	13	contributes	contribute	VBZ
cord-017585-0llgr357	114	14	to	to	IN
cord-017585-0llgr357	114	15	the	the	DT
cord-017585-0llgr357	114	16	lower	low	JJR
cord-017585-0llgr357	114	17	half	half	JJ
cord-017585-0llgr357	114	18	-	-	HYPH
cord-017585-0llgr357	114	19	life	life	NN
cord-017585-0llgr357	114	20	(	(	-LRB-
cord-017585-0llgr357	114	21	t	t	NN
cord-017585-0llgr357	114	22	1/2	1/2	CD
cord-017585-0llgr357	114	23	)	)	-RRB-
cord-017585-0llgr357	114	24	of	of	IN
cord-017585-0llgr357	114	25	serum	serum	NN
cord-017585-0llgr357	114	26	Ang	Ang	NNP
cord-017585-0llgr357	114	27	II	II	NNP
cord-017585-0llgr357	114	28	in	in	IN
cord-017585-0llgr357	114	29	males	male	NNS
cord-017585-0llgr357	114	30	.	.	.
cord-017585-0llgr357	115	1	Addition	addition	NN
cord-017585-0llgr357	115	2	of	of	IN
cord-017585-0llgr357	115	3	the	the	DT
cord-017585-0llgr357	115	4	specific	specific	JJ
cord-017585-0llgr357	115	5	ACE2	ACE2	NNP
cord-017585-0llgr357	115	6	inhibitor	inhibitor	NN
cord-017585-0llgr357	115	7	abolished	abolish	VBD
cord-017585-0llgr357	115	8	the	the	DT
cord-017585-0llgr357	115	9	conversion	conversion	NN
cord-017585-0llgr357	115	10	of	of	IN
cord-017585-0llgr357	115	11	Ang	Ang	NNP
cord-017585-0llgr357	115	12	II	II	NNP
cord-017585-0llgr357	115	13	to	to	IN
cord-017585-0llgr357	115	14	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	115	15	-	-	HYPH
cord-017585-0llgr357	115	16	7	7	CD
cord-017585-0llgr357	115	17	)	)	-RRB-
cord-017585-0llgr357	115	18	as	as	IN
cord-017585-0llgr357	115	19	measured	measure	VBN
cord-017585-0llgr357	115	20	by	by	IN
cord-017585-0llgr357	115	21	a	a	DT
cord-017585-0llgr357	115	22	HPLC-125	HPLC-125	NNP
cord-017585-0llgr357	115	23	I	i	NN
cord-017585-0llgr357	115	24	-	-	HYPH
cord-017585-0llgr357	115	25	detector	detector	NN
cord-017585-0llgr357	115	26	and	and	CC
cord-017585-0llgr357	115	27	markedly	markedly	RB
cord-017585-0llgr357	115	28	increased	increase	VBD
cord-017585-0llgr357	115	29	the	the	DT
cord-017585-0llgr357	115	30	Ang	Ang	NNP
cord-017585-0llgr357	115	31	II-[t	II-[t	NNP
cord-017585-0llgr357	115	32	1/2	1/2	CD
cord-017585-0llgr357	115	33	]	]	-RRB-
cord-017585-0llgr357	115	34	in	in	IN
cord-017585-0llgr357	115	35	both	both	DT
cord-017585-0llgr357	115	36	male	male	NN
cord-017585-0llgr357	115	37	(	(	-LRB-
cord-017585-0llgr357	115	38	6	6	CD
cord-017585-0llgr357	115	39	fold	fold	VB
cord-017585-0llgr357	115	40	)	)	-RRB-
cord-017585-0llgr357	115	41	and	and	CC
cord-017585-0llgr357	115	42	female	female	JJ
cord-017585-0llgr357	115	43	(	(	-LRB-
cord-017585-0llgr357	115	44	3	3	CD
cord-017585-0llgr357	115	45	fold	fold	VB
cord-017585-0llgr357	115	46	)	)	-RRB-
cord-017585-0llgr357	115	47	sheep	sheep	NN
cord-017585-0llgr357	115	48	(	(	-LRB-
cord-017585-0llgr357	115	49	Fig	fig	NN
cord-017585-0llgr357	115	50	.	.	.
cord-017585-0llgr357	115	51	3	3	CD
cord-017585-0llgr357	115	52	)	)	-RRB-
cord-017585-0llgr357	115	53	.	.	.
cord-017585-0llgr357	116	1	These	these	DT
cord-017585-0llgr357	116	2	ex	ex	AFX
cord-017585-0llgr357	116	3	vivo	vivo	NN
cord-017585-0llgr357	116	4	data	datum	NNS
cord-017585-0llgr357	116	5	in	in	IN
cord-017585-0llgr357	116	6	sheep	sheep	NN
cord-017585-0llgr357	116	7	serum	serum	NN
cord-017585-0llgr357	116	8	demonstrate	demonstrate	VBP
cord-017585-0llgr357	116	9	that	that	IN
cord-017585-0llgr357	116	10	circulating	circulate	VBG
cord-017585-0llgr357	116	11	ACE2	ACE2	NNP
cord-017585-0llgr357	116	12	constitutes	constitute	VBZ
cord-017585-0llgr357	116	13	a	a	DT
cord-017585-0llgr357	116	14	major	major	JJ
cord-017585-0llgr357	116	15	pathway	pathway	NN
cord-017585-0llgr357	116	16	in	in	IN
cord-017585-0llgr357	116	17	the	the	DT
cord-017585-0llgr357	116	18	metabolism	metabolism	NN
cord-017585-0llgr357	116	19	of	of	IN
cord-017585-0llgr357	116	20	Ang	Ang	NNP
cord-017585-0llgr357	116	21	II	II	NNP
cord-017585-0llgr357	116	22	and	and	CC
cord-017585-0llgr357	116	23	support	support	VB
cord-017585-0llgr357	116	24	the	the	DT
cord-017585-0llgr357	116	25	increase	increase	NN
cord-017585-0llgr357	116	26	in	in	IN
cord-017585-0llgr357	116	27	circulating	circulate	VBG
cord-017585-0llgr357	116	28	Ang	Ang	NNP
cord-017585-0llgr357	116	29	II	II	NNP
cord-017585-0llgr357	116	30	levels	level	NNS
cord-017585-0llgr357	116	31	in	in	IN
cord-017585-0llgr357	116	32	the	the	DT
cord-017585-0llgr357	116	33	ACE2	ACE2	NNP
cord-017585-0llgr357	116	34	null	null	NN
cord-017585-0llgr357	116	35	mouse	mouse	NN
cord-017585-0llgr357	116	36	.	.	.
cord-017585-0llgr357	117	1	Furthermore	furthermore	RB
cord-017585-0llgr357	117	2	,	,	,
cord-017585-0llgr357	117	3	we	-PRON-	PRP
cord-017585-0llgr357	117	4	did	do	VBD
cord-017585-0llgr357	117	5	not	not	RB
cord-017585-0llgr357	117	6	find	find	VB
cord-017585-0llgr357	117	7	that	that	IN
cord-017585-0llgr357	117	8	soluble	soluble	JJ
cord-017585-0llgr357	117	9	ACE2	ACE2	NNP
cord-017585-0llgr357	117	10	in	in	IN
cord-017585-0llgr357	117	11	the	the	DT
cord-017585-0llgr357	117	12	serum	serum	NN
cord-017585-0llgr357	117	13	contributed	contribute	VBD
cord-017585-0llgr357	117	14	to	to	IN
cord-017585-0llgr357	117	15	the	the	DT
cord-017585-0llgr357	117	16	direct	direct	JJ
cord-017585-0llgr357	117	17	conversion	conversion	NN
cord-017585-0llgr357	117	18	of	of	IN
cord-017585-0llgr357	117	19	Ang	Ang	NNP
cord-017585-0llgr357	117	20	I	I	NNP
cord-017585-0llgr357	117	21	to	to	IN
cord-017585-0llgr357	117	22	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	117	23	-	-	HYPH
cord-017585-0llgr357	117	24	9	9	CD
cord-017585-0llgr357	117	25	)	)	-RRB-
cord-017585-0llgr357	117	26	even	even	RB
cord-017585-0llgr357	117	27	in	in	IN
cord-017585-0llgr357	117	28	the	the	DT
cord-017585-0llgr357	117	29	presence	presence	NN
cord-017585-0llgr357	117	30	of	of	IN
cord-017585-0llgr357	117	31	complete	complete	JJ
cord-017585-0llgr357	117	32	ACE	ace	NN
cord-017585-0llgr357	117	33	inhibition	inhibition	NN
cord-017585-0llgr357	117	34	(	(	-LRB-
cord-017585-0llgr357	117	35	Shaltout	Shaltout	NNP
cord-017585-0llgr357	117	36	et	et	NNP
cord-017585-0llgr357	117	37	al	al	NNP
cord-017585-0llgr357	117	38	2007	2007	CD
cord-017585-0llgr357	117	39	)	)	-RRB-
cord-017585-0llgr357	117	40	.	.	.
cord-017585-0llgr357	118	1	Within	within	IN
cord-017585-0llgr357	118	2	the	the	DT
cord-017585-0llgr357	118	3	kidney	kidney	NN
cord-017585-0llgr357	118	4	,	,	,
cord-017585-0llgr357	118	5	ACE2	ACE2	NNP
cord-017585-0llgr357	118	6	is	be	VBZ
cord-017585-0llgr357	118	7	primarily	primarily	RB
cord-017585-0llgr357	118	8	localized	localize	VBN
cord-017585-0llgr357	118	9	to	to	IN
cord-017585-0llgr357	118	10	the	the	DT
cord-017585-0llgr357	118	11	apical	apical	JJ
cord-017585-0llgr357	118	12	aspect	aspect	NN
cord-017585-0llgr357	118	13	of	of	IN
cord-017585-0llgr357	118	14	the	the	DT
cord-017585-0llgr357	118	15	proximal	proximal	JJ
cord-017585-0llgr357	118	16	tubule	tubule	NN
cord-017585-0llgr357	118	17	epithelium	epithelium	NN
cord-017585-0llgr357	118	18	.	.	.
cord-017585-0llgr357	119	1	Indeed	indeed	RB
cord-017585-0llgr357	119	2	,	,	,
cord-017585-0llgr357	119	3	expression	expression	NN
cord-017585-0llgr357	119	4	of	of	IN
cord-017585-0llgr357	119	5	ACE2	ACE2	NNP
cord-017585-0llgr357	119	6	in	in	IN
cord-017585-0llgr357	119	7	the	the	DT
cord-017585-0llgr357	119	8	renal	renal	JJ
cord-017585-0llgr357	119	9	MDCK	MDCK	NNP
cord-017585-0llgr357	119	10	cell	cell	NN
cord-017585-0llgr357	119	11	line	line	NN
cord-017585-0llgr357	119	12	revealed	reveal	VBD
cord-017585-0llgr357	119	13	exclusive	exclusive	JJ
cord-017585-0llgr357	119	14	trafficking	trafficking	NN
cord-017585-0llgr357	119	15	of	of	IN
cord-017585-0llgr357	119	16	the	the	DT
cord-017585-0llgr357	119	17	enzyme	enzyme	NN
cord-017585-0llgr357	119	18	to	to	IN
cord-017585-0llgr357	119	19	the	the	DT
cord-017585-0llgr357	119	20	apical	apical	JJ
cord-017585-0llgr357	119	21	side	side	NN
cord-017585-0llgr357	119	22	,	,	,
cord-017585-0llgr357	119	23	while	while	IN
cord-017585-0llgr357	119	24	the	the	DT
cord-017585-0llgr357	119	25	distribution	distribution	NN
cord-017585-0llgr357	119	26	of	of	IN
cord-017585-0llgr357	119	27	expressed	express	VBN
cord-017585-0llgr357	119	28	ACE	ACE	NNP
cord-017585-0llgr357	119	29	was	be	VBD
cord-017585-0llgr357	119	30	different	different	JJ
cord-017585-0llgr357	119	31	,	,	,
cord-017585-0llgr357	119	32	trafficking	traffic	VBG
cord-017585-0llgr357	119	33	to	to	IN
cord-017585-0llgr357	119	34	the	the	DT
cord-017585-0llgr357	119	35	basolateral	basolateral	JJ
cord-017585-0llgr357	119	36	and	and	CC
cord-017585-0llgr357	119	37	luminal	luminal	JJ
cord-017585-0llgr357	119	38	aspects	aspect	NNS
cord-017585-0llgr357	119	39	of	of	IN
cord-017585-0llgr357	119	40	the	the	DT
cord-017585-0llgr357	119	41	cell	cell	NN
cord-017585-0llgr357	120	1	(	(	-LRB-
cord-017585-0llgr357	120	2	Guy	Guy	NNP
cord-017585-0llgr357	120	3	et	et	NNP
cord-017585-0llgr357	120	4	al	al	NNP
cord-017585-0llgr357	120	5	2005	2005	CD
cord-017585-0llgr357	120	6	)	)	-RRB-
cord-017585-0llgr357	120	7	.	.	.
cord-017585-0llgr357	121	1	Consistent	consistent	JJ
cord-017585-0llgr357	121	2	with	with	IN
cord-017585-0llgr357	121	3	the	the	DT
cord-017585-0llgr357	121	4	apical	apical	JJ
cord-017585-0llgr357	121	5	expression	expression	NN
cord-017585-0llgr357	121	6	of	of	IN
cord-017585-0llgr357	121	7	ACE2	ACE2	NNP
cord-017585-0llgr357	121	8	in	in	IN
cord-017585-0llgr357	121	9	the	the	DT
cord-017585-0llgr357	121	10	renal	renal	JJ
cord-017585-0llgr357	121	11	epithelium	epithelium	NN
cord-017585-0llgr357	121	12	,	,	,
cord-017585-0llgr357	121	13	we	-PRON-	PRP
cord-017585-0llgr357	121	14	found	find	VBD
cord-017585-0llgr357	121	15	significant	significant	JJ
cord-017585-0llgr357	121	16	urinary	urinary	JJ
cord-017585-0llgr357	121	17	ACE2	ACE2	NNP
cord-017585-0llgr357	121	18	activity	activity	NN
cord-017585-0llgr357	121	19	that	that	WDT
cord-017585-0llgr357	121	20	converted	convert	VBD
cord-017585-0llgr357	121	21	Ang	Ang	NNP
cord-017585-0llgr357	121	22	II	II	NNP
cord-017585-0llgr357	121	23	to	to	IN
cord-017585-0llgr357	121	24	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	121	25	-	-	HYPH
cord-017585-0llgr357	121	26	7	7	CD
cord-017585-0llgr357	121	27	)	)	-RRB-
cord-017585-0llgr357	121	28	,	,	,
cord-017585-0llgr357	121	29	but	but	CC
cord-017585-0llgr357	121	30	did	do	VBD
cord-017585-0llgr357	121	31	not	not	RB
cord-017585-0llgr357	121	32	process	process	VB
cord-017585-0llgr357	121	33	Ang	Ang	NNP
cord-017585-0llgr357	121	34	I	-PRON-	PRP
cord-017585-0llgr357	121	35	to	to	IN
cord-017585-0llgr357	121	36	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	121	37	-	-	HYPH
cord-017585-0llgr357	121	38	9	9	CD
cord-017585-0llgr357	121	39	)	)	-RRB-
cord-017585-0llgr357	122	1	(	(	-LRB-
cord-017585-0llgr357	122	2	Shaltout	Shaltout	NNP
cord-017585-0llgr357	122	3	et	et	NNP
cord-017585-0llgr357	122	4	al	al	NNP
cord-017585-0llgr357	122	5	2007	2007	CD
cord-017585-0llgr357	122	6	)	)	-RRB-
cord-017585-0llgr357	122	7	.	.	.
cord-017585-0llgr357	123	1	The	the	DT
cord-017585-0llgr357	123	2	glycosylated	glycosylated	JJ
cord-017585-0llgr357	123	3	form	form	NN
cord-017585-0llgr357	123	4	of	of	IN
cord-017585-0llgr357	123	5	ACE2	ACE2	NNP
cord-017585-0llgr357	123	6	is	be	VBZ
cord-017585-0llgr357	123	7	approximately	approximately	RB
cord-017585-0llgr357	123	8	120,000	120,000	CD
cord-017585-0llgr357	123	9	Daltons	dalton	NNS
cord-017585-0llgr357	123	10	and	and	CC
cord-017585-0llgr357	123	11	the	the	DT
cord-017585-0llgr357	123	12	filtration	filtration	NN
cord-017585-0llgr357	123	13	of	of	IN
cord-017585-0llgr357	123	14	the	the	DT
cord-017585-0llgr357	123	15	enzyme	enzyme	NN
cord-017585-0llgr357	123	16	into	into	IN
cord-017585-0llgr357	123	17	the	the	DT
cord-017585-0llgr357	123	18	tubular	tubular	JJ
cord-017585-0llgr357	123	19	fluid	fluid	NN
cord-017585-0llgr357	123	20	is	be	VBZ
cord-017585-0llgr357	123	21	highly	highly	RB
cord-017585-0llgr357	123	22	unlikely	unlikely	JJ
cord-017585-0llgr357	123	23	(	(	-LRB-
cord-017585-0llgr357	123	24	Shaltout	Shaltout	NNP
cord-017585-0llgr357	123	25	et	et	NNP
cord-017585-0llgr357	123	26	al	al	NNP
cord-017585-0llgr357	123	27	2007	2007	CD
cord-017585-0llgr357	123	28	)	)	-RRB-
cord-017585-0llgr357	123	29	.	.	.
cord-017585-0llgr357	124	1	In	in	IN
cord-017585-0llgr357	124	2	this	this	DT
cord-017585-0llgr357	124	3	regard	regard	NN
cord-017585-0llgr357	124	4	,	,	,
cord-017585-0llgr357	124	5	Lambert	Lambert	NNP
cord-017585-0llgr357	124	6	and	and	CC
cord-017585-0llgr357	124	7	colleagues	colleague	NNS
cord-017585-0llgr357	124	8	report	report	VBP
cord-017585-0llgr357	124	9	that	that	IN
cord-017585-0llgr357	124	10	the	the	DT
cord-017585-0llgr357	124	11	metallopeptidase	metallopeptidase	NN
cord-017585-0llgr357	124	12	ADAM	ADAM	NNP
cord-017585-0llgr357	124	13	17	17	CD
cord-017585-0llgr357	124	14	may	may	MD
cord-017585-0llgr357	124	15	function	function	VB
cord-017585-0llgr357	124	16	as	as	IN
cord-017585-0llgr357	124	17	a	a	DT
cord-017585-0llgr357	124	18	secretase	secretase	NN
cord-017585-0llgr357	124	19	to	to	TO
cord-017585-0llgr357	124	20	release	release	VB
cord-017585-0llgr357	124	21	ACE2	ACE2	NNP
cord-017585-0llgr357	124	22	from	from	IN
cord-017585-0llgr357	124	23	extracellular	extracellular	JJ
cord-017585-0llgr357	124	24	side	side	NN
cord-017585-0llgr357	124	25	of	of	IN
cord-017585-0llgr357	124	26	the	the	DT
cord-017585-0llgr357	124	27	cell	cell	NN
cord-017585-0llgr357	124	28	membrane	membrane	NN
cord-017585-0llgr357	124	29	.	.	.
cord-017585-0llgr357	125	1	Interestingly	interestingly	RB
cord-017585-0llgr357	125	2	,	,	,
cord-017585-0llgr357	125	3	ADAM	ADAM	NNP
cord-017585-0llgr357	125	4	17	17	CD
cord-017585-0llgr357	125	5	does	do	VBZ
cord-017585-0llgr357	125	6	not	not	RB
cord-017585-0llgr357	125	7	release	release	VB
cord-017585-0llgr357	125	8	ACE	ace	NN
cord-017585-0llgr357	125	9	suggesting	suggest	VBG
cord-017585-0llgr357	125	10	that	that	IN
cord-017585-0llgr357	125	11	the	the	DT
cord-017585-0llgr357	125	12	regulation	regulation	NN
cord-017585-0llgr357	125	13	for	for	IN
cord-017585-0llgr357	125	14	the	the	DT
cord-017585-0llgr357	125	15	secretion	secretion	NN
cord-017585-0llgr357	125	16	for	for	IN
cord-017585-0llgr357	125	17	ACE	ACE	NNP
cord-017585-0llgr357	125	18	and	and	CC
cord-017585-0llgr357	125	19	ACE2	ACE2	NNP
cord-017585-0llgr357	125	20	is	be	VBZ
cord-017585-0llgr357	125	21	distinct	distinct	JJ
cord-017585-0llgr357	125	22	.	.	.
cord-017585-0llgr357	126	1	The	the	DT
cord-017585-0llgr357	126	2	localization	localization	NN
cord-017585-0llgr357	126	3	of	of	IN
cord-017585-0llgr357	126	4	ACE2	ACE2	NNP
cord-017585-0llgr357	126	5	in	in	IN
cord-017585-0llgr357	126	6	the	the	DT
cord-017585-0llgr357	126	7	proximal	proximal	JJ
cord-017585-0llgr357	126	8	tubule	tubule	NN
cord-017585-0llgr357	126	9	epithelium	epithelium	NN
cord-017585-0llgr357	126	10	along	along	IN
cord-017585-0llgr357	126	11	with	with	IN
cord-017585-0llgr357	126	12	other	other	JJ
cord-017585-0llgr357	126	13	elements	element	NNS
cord-017585-0llgr357	126	14	of	of	IN
cord-017585-0llgr357	126	15	the	the	DT
cord-017585-0llgr357	126	16	RAS	RAS	NNP
cord-017585-0llgr357	126	17	(	(	-LRB-
cord-017585-0llgr357	126	18	ACE	ACE	NNP
cord-017585-0llgr357	126	19	,	,	,
cord-017585-0llgr357	126	20	angiotensinogen	angiotensinogen	NNP
cord-017585-0llgr357	126	21	,	,	,
cord-017585-0llgr357	126	22	Ang	Ang	NNP
cord-017585-0llgr357	126	23	receptors	receptor	NNS
cord-017585-0llgr357	126	24	)	)	-RRB-
cord-017585-0llgr357	126	25	supports	support	VBZ
cord-017585-0llgr357	126	26	a	a	DT
cord-017585-0llgr357	126	27	role	role	NN
cord-017585-0llgr357	126	28	for	for	IN
cord-017585-0llgr357	126	29	the	the	DT
cord-017585-0llgr357	126	30	enzyme	enzyme	NN
cord-017585-0llgr357	126	31	in	in	IN
cord-017585-0llgr357	126	32	the	the	DT
cord-017585-0llgr357	126	33	processing	processing	NN
cord-017585-0llgr357	126	34	of	of	IN
cord-017585-0llgr357	126	35	angiotensin	angiotensin	NN
cord-017585-0llgr357	126	36	peptides	peptide	NNS
cord-017585-0llgr357	126	37	.	.	.
cord-017585-0llgr357	127	1	In	in	IN
cord-017585-0llgr357	127	2	the	the	DT
cord-017585-0llgr357	127	3	rat	rat	NN
cord-017585-0llgr357	127	4	kidney	kidney	NN
cord-017585-0llgr357	127	5	,	,	,
cord-017585-0llgr357	127	6	Burns	Burns	NNP
cord-017585-0llgr357	127	7	and	and	CC
cord-017585-0llgr357	127	8	colleagues	colleague	NNS
cord-017585-0llgr357	127	9	found	find	VBD
cord-017585-0llgr357	127	10	no	no	DT
cord-017585-0llgr357	127	11	evidence	evidence	NN
cord-017585-0llgr357	127	12	that	that	IN
cord-017585-0llgr357	127	13	ACE2	ACE2	NNP
cord-017585-0llgr357	127	14	or	or	CC
cord-017585-0llgr357	127	15	other	other	JJ
cord-017585-0llgr357	127	16	peptidases	peptidase	NNS
cord-017585-0llgr357	127	17	metabolize	metabolize	VBP
cord-017585-0llgr357	127	18	Ang	Ang	NNP
cord-017585-0llgr357	127	19	II	II	NNP
cord-017585-0llgr357	127	20	in	in	IN
cord-017585-0llgr357	127	21	proximal	proximal	JJ
cord-017585-0llgr357	127	22	tubule	tubule	NN
cord-017585-0llgr357	127	23	preparations	preparation	NNS
cord-017585-0llgr357	127	24	or	or	CC
cord-017585-0llgr357	127	25	in	in	IN
cord-017585-0llgr357	127	26	perfused	perfuse	VBN
cord-017585-0llgr357	127	27	proximal	proximal	JJ
cord-017585-0llgr357	127	28	tubule	tubule	NN
cord-017585-0llgr357	127	29	segments	segment	NNS
cord-017585-0llgr357	127	30	isolated	isolate	VBN
cord-017585-0llgr357	127	31	from	from	IN
cord-017585-0llgr357	127	32	male	male	JJ
cord-017585-0llgr357	127	33	Sprague	Sprague	NNP
cord-017585-0llgr357	127	34	Dawley	Dawley	NNP
cord-017585-0llgr357	127	35	rats	rat	NNS
cord-017585-0llgr357	127	36	.	.	.
cord-017585-0llgr357	128	1	However	however	RB
cord-017585-0llgr357	128	2	,	,	,
cord-017585-0llgr357	128	3	ACE2	ACE2	NNP
cord-017585-0llgr357	128	4	activity	activity	NN
cord-017585-0llgr357	128	5	was	be	VBD
cord-017585-0llgr357	128	6	clearly	clearly	RB
cord-017585-0llgr357	128	7	evident	evident	JJ
cord-017585-0llgr357	128	8	in	in	IN
cord-017585-0llgr357	128	9	the	the	DT
cord-017585-0llgr357	128	10	rat	rat	NN
cord-017585-0llgr357	128	11	tubules	tubule	NNS
cord-017585-0llgr357	128	12	as	as	IN
cord-017585-0llgr357	128	13	the	the	DT
cord-017585-0llgr357	128	14	conversion	conversion	NN
cord-017585-0llgr357	128	15	of	of	IN
cord-017585-0llgr357	128	16	exogenous	exogenous	JJ
cord-017585-0llgr357	128	17	Ang	Ang	NNP
cord-017585-0llgr357	128	18	I	-PRON-	PRP
cord-017585-0llgr357	128	19	to	to	IN
cord-017585-0llgr357	128	20	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	128	21	-	-	HYPH
cord-017585-0llgr357	128	22	9	9	CD
cord-017585-0llgr357	128	23	)	)	-RRB-
cord-017585-0llgr357	128	24	was	be	VBD
cord-017585-0llgr357	128	25	sensitive	sensitive	JJ
cord-017585-0llgr357	128	26	to	to	IN
cord-017585-0llgr357	128	27	the	the	DT
cord-017585-0llgr357	128	28	ACE2	ACE2	NNP
cord-017585-0llgr357	128	29	peptide	peptide	NN
cord-017585-0llgr357	128	30	inhibitor	inhibitor	NN
cord-017585-0llgr357	129	1	DX-600	dx-600	RB
cord-017585-0llgr357	129	2	.	.	.
cord-017585-0llgr357	130	1	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	130	2	-	-	HYPH
cord-017585-0llgr357	130	3	9	9	CD
cord-017585-0llgr357	130	4	)	)	-RRB-
cord-017585-0llgr357	130	5	was	be	VBD
cord-017585-0llgr357	130	6	subsequently	subsequently	RB
cord-017585-0llgr357	130	7	converted	convert	VBN
cord-017585-0llgr357	130	8	to	to	IN
cord-017585-0llgr357	130	9	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	130	10	-	-	HYPH
cord-017585-0llgr357	130	11	7	7	CD
cord-017585-0llgr357	130	12	)	)	-RRB-
cord-017585-0llgr357	130	13	by	by	IN
cord-017585-0llgr357	130	14	ACE	ACE	NNP
cord-017585-0llgr357	130	15	,	,	,
cord-017585-0llgr357	130	16	a	a	DT
cord-017585-0llgr357	130	17	pathway	pathway	NN
cord-017585-0llgr357	130	18	similar	similar	JJ
cord-017585-0llgr357	130	19	to	to	IN
cord-017585-0llgr357	130	20	that	that	DT
cord-017585-0llgr357	130	21	reported	report	VBN
cord-017585-0llgr357	130	22	for	for	IN
cord-017585-0llgr357	130	23	Ang	Ang	NNP
cord-017585-0llgr357	131	1	I	-PRON-	PRP
cord-017585-0llgr357	131	2	metabolism	metabolism	VBP
cord-017585-0llgr357	131	3	in	in	IN
cord-017585-0llgr357	131	4	isolated	isolate	VBN
cord-017585-0llgr357	131	5	cardiomyocytes	cardiomyocyte	NNS
cord-017585-0llgr357	131	6	(	(	-LRB-
cord-017585-0llgr357	131	7	Donoghue	Donoghue	NNP
cord-017585-0llgr357	131	8	et	et	NNP
cord-017585-0llgr357	131	9	al	al	NNP
cord-017585-0llgr357	131	10	2000	2000	CD
cord-017585-0llgr357	131	11	)	)	-RRB-
cord-017585-0llgr357	131	12	.	.	.
cord-017585-0llgr357	132	1	In	in	IN
cord-017585-0llgr357	132	2	contrast	contrast	NN
cord-017585-0llgr357	132	3	to	to	IN
cord-017585-0llgr357	132	4	the	the	DT
cord-017585-0llgr357	132	5	rat	rat	NN
cord-017585-0llgr357	132	6	,	,	,
cord-017585-0llgr357	132	7	we	-PRON-	PRP
cord-017585-0llgr357	132	8	found	find	VBD
cord-017585-0llgr357	132	9	that	that	IN
cord-017585-0llgr357	132	10	ACE2	ACE2	NNP
cord-017585-0llgr357	132	11	was	be	VBD
cord-017585-0llgr357	132	12	the	the	DT
cord-017585-0llgr357	132	13	predominant	predominant	JJ
cord-017585-0llgr357	132	14	activity	activity	NN
cord-017585-0llgr357	132	15	to	to	TO
cord-017585-0llgr357	132	16	convert	convert	VB
cord-017585-0llgr357	132	17	Ang	Ang	NNP
cord-017585-0llgr357	132	18	II	II	NNP
cord-017585-0llgr357	132	19	to	to	IN
cord-017585-0llgr357	132	20	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	132	21	-	-	HYPH
cord-017585-0llgr357	132	22	7	7	CD
cord-017585-0llgr357	132	23	)	)	-RRB-
cord-017585-0llgr357	132	24	in	in	IN
cord-017585-0llgr357	132	25	sheep	sheep	NN
cord-017585-0llgr357	132	26	proximal	proximal	JJ
cord-017585-0llgr357	132	27	tubules	tubule	NNS
cord-017585-0llgr357	132	28	(	(	-LRB-
cord-017585-0llgr357	132	29	Shaltout	Shaltout	NNP
cord-017585-0llgr357	132	30	et	et	NNP
cord-017585-0llgr357	132	31	al	al	NNP
cord-017585-0llgr357	132	32	2007	2007	CD
cord-017585-0llgr357	132	33	)	)	-RRB-
cord-017585-0llgr357	132	34	.	.	.
cord-017585-0llgr357	133	1	The	the	DT
cord-017585-0llgr357	133	2	addition	addition	NN
cord-017585-0llgr357	133	3	of	of	IN
cord-017585-0llgr357	133	4	the	the	DT
cord-017585-0llgr357	133	5	nonpeptide	nonpeptide	JJ
cord-017585-0llgr357	133	6	ACE2	ACE2	NNP
cord-017585-0llgr357	133	7	inhibitor	inhibitor	NN
cord-017585-0llgr357	133	8	MLN-4760	MLN-4760	NNP
cord-017585-0llgr357	133	9	significantly	significantly	RB
cord-017585-0llgr357	133	10	attenuated	attenuate	VBD
cord-017585-0llgr357	133	11	the	the	DT
cord-017585-0llgr357	133	12	metabolism	metabolism	NN
cord-017585-0llgr357	133	13	of	of	IN
cord-017585-0llgr357	133	14	Ang	Ang	NNP
cord-017585-0llgr357	133	15	II	II	NNP
cord-017585-0llgr357	133	16	at	at	IN
cord-017585-0llgr357	133	17	early	early	JJ
cord-017585-0llgr357	133	18	time	time	NN
cord-017585-0llgr357	133	19	points	point	NNS
cord-017585-0llgr357	133	20	.	.	.
cord-017585-0llgr357	134	1	However	however	RB
cord-017585-0llgr357	134	2	,	,	,
cord-017585-0llgr357	134	3	as	as	IN
cord-017585-0llgr357	134	4	shown	show	VBN
cord-017585-0llgr357	134	5	in	in	IN
cord-017585-0llgr357	134	6	Fig	Fig	NNP
cord-017585-0llgr357	134	7	.	.	.
cord-017585-0llgr357	135	1	4	4	LS
cord-017585-0llgr357	135	2	,	,	,
cord-017585-0llgr357	135	3	the	the	DT
cord-017585-0llgr357	135	4	significant	significant	JJ
cord-017585-0llgr357	135	5	ACE	ace	NN
cord-017585-0llgr357	135	6	and	and	CC
cord-017585-0llgr357	135	7	neprilysin	neprilysin	NNP
cord-017585-0llgr357	135	8	activities	activity	NNS
cord-017585-0llgr357	135	9	required	require	VBD
cord-017585-0llgr357	135	10	prior	prior	JJ
cord-017585-0llgr357	135	11	inhibition	inhibition	NN
cord-017585-0llgr357	135	12	to	to	TO
cord-017585-0llgr357	135	13	protect	protect	VB
cord-017585-0llgr357	135	14	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	135	15	-	-	HYPH
cord-017585-0llgr357	135	16	7	7	CD
cord-017585-0llgr357	135	17	)	)	-RRB-
cord-017585-0llgr357	135	18	from	from	IN
cord-017585-0llgr357	135	19	rapid	rapid	JJ
cord-017585-0llgr357	135	20	degradation	degradation	NN
cord-017585-0llgr357	135	21	in	in	IN
cord-017585-0llgr357	135	22	the	the	DT
cord-017585-0llgr357	135	23	proximal	proximal	JJ
cord-017585-0llgr357	135	24	tubules	tubule	NNS
cord-017585-0llgr357	135	25	.	.	.
cord-017585-0llgr357	136	1	We	-PRON-	PRP
cord-017585-0llgr357	136	2	could	could	MD
cord-017585-0llgr357	136	3	not	not	RB
cord-017585-0llgr357	136	4	demonstrate	demonstrate	VB
cord-017585-0llgr357	136	5	that	that	IN
cord-017585-0llgr357	136	6	ACE2	ACE2	NNP
cord-017585-0llgr357	136	7	participated	participate	VBD
cord-017585-0llgr357	136	8	in	in	IN
cord-017585-0llgr357	136	9	the	the	DT
cord-017585-0llgr357	136	10	direct	direct	JJ
cord-017585-0llgr357	136	11	metabolism	metabolism	NN
cord-017585-0llgr357	136	12	of	of	IN
cord-017585-0llgr357	136	13	Ang	Ang	NNP
cord-017585-0llgr357	136	14	I	I	NNP
cord-017585-0llgr357	136	15	,	,	,
cord-017585-0llgr357	136	16	particularly	particularly	RB
cord-017585-0llgr357	136	17	under	under	IN
cord-017585-0llgr357	136	18	conditions	condition	NNS
cord-017585-0llgr357	136	19	where	where	WRB
cord-017585-0llgr357	136	20	other	other	JJ
cord-017585-0llgr357	136	21	enzymatic	enzymatic	JJ
cord-017585-0llgr357	136	22	pathways	pathway	NNS
cord-017585-0llgr357	136	23	were	be	VBD
cord-017585-0llgr357	136	24	blocked	block	VBN
cord-017585-0llgr357	136	25	(	(	-LRB-
cord-017585-0llgr357	136	26	Shaltout	Shaltout	NNP
cord-017585-0llgr357	136	27	et	et	NNP
cord-017585-0llgr357	136	28	al	al	NNP
cord-017585-0llgr357	136	29	2007	2007	CD
cord-017585-0llgr357	136	30	)	)	-RRB-
cord-017585-0llgr357	136	31	.	.	.
cord-017585-0llgr357	137	1	Indeed	indeed	RB
cord-017585-0llgr357	137	2	,	,	,
cord-017585-0llgr357	137	3	Ang	Ang	NNP
cord-017585-0llgr357	137	4	I	-PRON-	PRP
cord-017585-0llgr357	137	5	was	be	VBD
cord-017585-0llgr357	137	6	directly	directly	RB
cord-017585-0llgr357	137	7	converted	convert	VBN
cord-017585-0llgr357	137	8	to	to	IN
cord-017585-0llgr357	137	9	Ang	Ang	NNP
cord-017585-0llgr357	137	10	II	II	NNP
cord-017585-0llgr357	137	11	and	and	CC
cord-017585-0llgr357	137	12	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	137	13	-	-	HYPH
cord-017585-0llgr357	137	14	7	7	CD
cord-017585-0llgr357	137	15	)	)	-RRB-
cord-017585-0llgr357	137	16	via	via	IN
cord-017585-0llgr357	137	17	ACE	ACE	NNP
cord-017585-0llgr357	137	18	and	and	CC
cord-017585-0llgr357	137	19	neprilysin	neprilysin	NNP
cord-017585-0llgr357	137	20	,	,	,
cord-017585-0llgr357	137	21	respectively	respectively	RB
cord-017585-0llgr357	137	22	.	.	.
cord-017585-0llgr357	138	1	The	the	DT
cord-017585-0llgr357	138	2	preferred	preferred	JJ
cord-017585-0llgr357	138	3	conversion	conversion	NN
cord-017585-0llgr357	138	4	of	of	IN
cord-017585-0llgr357	138	5	Ang	Ang	NNP
cord-017585-0llgr357	138	6	II	II	NNP
cord-017585-0llgr357	138	7	to	to	IN
cord-017585-0llgr357	138	8	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	138	9	-	-	HYPH
cord-017585-0llgr357	138	10	7	7	CD
cord-017585-0llgr357	138	11	)	)	-RRB-
cord-017585-0llgr357	138	12	by	by	IN
cord-017585-0llgr357	138	13	ACE2	ACE2	NNP
cord-017585-0llgr357	138	14	in	in	IN
cord-017585-0llgr357	138	15	the	the	DT
cord-017585-0llgr357	138	16	sheep	sheep	NN
cord-017585-0llgr357	138	17	kidney	kidney	NN
cord-017585-0llgr357	138	18	is	be	VBZ
cord-017585-0llgr357	138	19	entirely	entirely	RB
cord-017585-0llgr357	138	20	consistent	consistent	JJ
cord-017585-0llgr357	138	21	with	with	IN
cord-017585-0llgr357	138	22	kinetic	kinetic	JJ
cord-017585-0llgr357	138	23	studies	study	NNS
cord-017585-0llgr357	138	24	on	on	IN
cord-017585-0llgr357	138	25	various	various	JJ
cord-017585-0llgr357	138	26	peptide	peptide	NN
cord-017585-0llgr357	138	27	substrates	substrate	NNS
cord-017585-0llgr357	138	28	by	by	IN
cord-017585-0llgr357	138	29	the	the	DT
cord-017585-0llgr357	138	30	human	human	JJ
cord-017585-0llgr357	138	31	enzyme	enzyme	NN
cord-017585-0llgr357	139	1	(	(	-LRB-
cord-017585-0llgr357	139	2	Rice	Rice	NNP
cord-017585-0llgr357	139	3	et	et	NNP
cord-017585-0llgr357	139	4	al	al	NNP
cord-017585-0llgr357	139	5	2004	2004	CD
cord-017585-0llgr357	139	6	;	;	:
cord-017585-0llgr357	139	7	Vickers	Vickers	NNP
cord-017585-0llgr357	139	8	et	et	NNP
cord-017585-0llgr357	139	9	al	al	NNP
cord-017585-0llgr357	139	10	2002	2002	CD
cord-017585-0llgr357	139	11	)	)	-RRB-
cord-017585-0llgr357	139	12	,	,	.
cord-017585-0llgr357	140	1	as	as	IN
cord-017585-0llgr357	140	2	well	well	RB
cord-017585-0llgr357	140	3	studies	study	NNS
cord-017585-0llgr357	140	4	in	in	IN
cord-017585-0llgr357	140	5	membrane	membrane	NN
cord-017585-0llgr357	140	6	fractions	fraction	NNS
cord-017585-0llgr357	140	7	of	of	IN
cord-017585-0llgr357	140	8	mouse	mouse	NN
cord-017585-0llgr357	140	9	kidney	kidney	NN
cord-017585-0llgr357	140	10	and	and	CC
cord-017585-0llgr357	140	11	rat	rat	NN
cord-017585-0llgr357	140	12	renal	renal	JJ
cord-017585-0llgr357	140	13	cortex	cortex	NNP
cord-017585-0llgr357	140	14	that	that	WDT
cord-017585-0llgr357	140	15	demonstrated	demonstrate	VBD
cord-017585-0llgr357	140	16	ACE2-dependent	ACE2-dependent	NNP
cord-017585-0llgr357	140	17	conversion	conversion	NN
cord-017585-0llgr357	140	18	of	of	IN
cord-017585-0llgr357	140	19	Ang	Ang	NNP
cord-017585-0llgr357	140	20	II	II	NNP
cord-017585-0llgr357	140	21	to	to	IN
cord-017585-0llgr357	140	22	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	140	23	-	-	HYPH
cord-017585-0llgr357	140	24	7	7	CD
cord-017585-0llgr357	140	25	)	)	-RRB-
cord-017585-0llgr357	141	1	(	(	-LRB-
cord-017585-0llgr357	141	2	Elased	Elased	NNP
cord-017585-0llgr357	141	3	et	et	FW
cord-017585-0llgr357	141	4	al	al	NNP
cord-017585-0llgr357	141	5	2006	2006	CD
cord-017585-0llgr357	141	6	;	;	:
cord-017585-0llgr357	141	7	Ferrario	Ferrario	NNP
cord-017585-0llgr357	141	8	et	et	NNP
cord-017585-0llgr357	141	9	al	al	NNP
cord-017585-0llgr357	141	10	2005b	2005b	CD
cord-017585-0llgr357	141	11	)	)	-RRB-
cord-017585-0llgr357	141	12	.	.	.
cord-017585-0llgr357	142	1	An	an	DT
cord-017585-0llgr357	142	2	explanation	explanation	NN
cord-017585-0llgr357	142	3	for	for	IN
cord-017585-0llgr357	142	4	the	the	DT
cord-017585-0llgr357	142	5	discrepancy	discrepancy	NN
cord-017585-0llgr357	142	6	in	in	IN
cord-017585-0llgr357	142	7	the	the	DT
cord-017585-0llgr357	142	8	metabolism	metabolism	NN
cord-017585-0llgr357	142	9	studies	study	NNS
cord-017585-0llgr357	142	10	for	for	IN
cord-017585-0llgr357	142	11	angiotensin	angiotensin	NN
cord-017585-0llgr357	142	12	metabolism	metabolism	NN
cord-017585-0llgr357	142	13	is	be	VBZ
cord-017585-0llgr357	142	14	not	not	RB
cord-017585-0llgr357	142	15	readily	readily	RB
cord-017585-0llgr357	142	16	apparent	apparent	JJ
cord-017585-0llgr357	142	17	;	;	:
cord-017585-0llgr357	142	18	however	however	RB
cord-017585-0llgr357	142	19	,	,	,
cord-017585-0llgr357	142	20	if	if	IN
cord-017585-0llgr357	142	21	the	the	DT
cord-017585-0llgr357	142	22	rat	rat	NN
cord-017585-0llgr357	142	23	exhibits	exhibit	VBZ
cord-017585-0llgr357	142	24	different	different	JJ
cord-017585-0llgr357	142	25	kinetic	kinetic	JJ
cord-017585-0llgr357	142	26	properties	property	NNS
cord-017585-0llgr357	142	27	for	for	IN
cord-017585-0llgr357	142	28	Ang	Ang	NNP
cord-017585-0llgr357	142	29	I	I	NNP
cord-017585-0llgr357	142	30	and	and	CC
cord-017585-0llgr357	142	31	Ang	Ang	NNP
cord-017585-0llgr357	142	32	II	II	NNP
cord-017585-0llgr357	142	33	than	than	IN
cord-017585-0llgr357	142	34	sheep	sheep	NNS
cord-017585-0llgr357	142	35	or	or	CC
cord-017585-0llgr357	142	36	human	human	NN
cord-017585-0llgr357	142	37	,	,	,
cord-017585-0llgr357	142	38	then	then	RB
cord-017585-0llgr357	142	39	the	the	DT
cord-017585-0llgr357	142	40	role	role	NN
cord-017585-0llgr357	142	41	of	of	IN
cord-017585-0llgr357	142	42	ACE2	ACE2	NNP
cord-017585-0llgr357	142	43	is	be	VBZ
cord-017585-0llgr357	142	44	likely	likely	JJ
cord-017585-0llgr357	142	45	to	to	TO
cord-017585-0llgr357	142	46	be	be	VB
cord-017585-0llgr357	142	47	quite	quite	RB
cord-017585-0llgr357	142	48	different	different	JJ
cord-017585-0llgr357	142	49	among	among	IN
cord-017585-0llgr357	142	50	species	specie	NNS
cord-017585-0llgr357	142	51	.	.	.
cord-017585-0llgr357	143	1	Additionally	additionally	RB
cord-017585-0llgr357	143	2	,	,	,
cord-017585-0llgr357	143	3	these	these	DT
cord-017585-0llgr357	143	4	studies	study	NNS
cord-017585-0llgr357	143	5	have	have	VBP
cord-017585-0llgr357	143	6	important	important	JJ
cord-017585-0llgr357	143	7	Figure	figure	NN
cord-017585-0llgr357	143	8	4	4	CD
cord-017585-0llgr357	143	9	.	.	.
cord-017585-0llgr357	144	1	ACE2	ACE2	NNP
cord-017585-0llgr357	144	2	inhibition	inhibition	NN
cord-017585-0llgr357	144	3	blocks	block	VBZ
cord-017585-0llgr357	144	4	the	the	DT
cord-017585-0llgr357	144	5	conversion	conversion	NN
cord-017585-0llgr357	144	6	of	of	IN
cord-017585-0llgr357	144	7	Ang	Ang	NNP
cord-017585-0llgr357	144	8	II	II	NNP
cord-017585-0llgr357	144	9	to	to	IN
cord-017585-0llgr357	144	10	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	144	11	-	-	HYPH
cord-017585-0llgr357	144	12	7	7	CD
cord-017585-0llgr357	144	13	)	)	-RRB-
cord-017585-0llgr357	144	14	in	in	IN
cord-017585-0llgr357	144	15	isolated	isolate	VBN
cord-017585-0llgr357	144	16	proximal	proximal	JJ
cord-017585-0llgr357	144	17	tubules	tubule	NNS
cord-017585-0llgr357	144	18	from	from	IN
cord-017585-0llgr357	144	19	female	female	JJ
cord-017585-0llgr357	144	20	sheep	sheep	NNS
cord-017585-0llgr357	144	21	.	.	.
cord-017585-0llgr357	145	1	Sequential	sequential	JJ
cord-017585-0llgr357	145	2	addition	addition	NN
cord-017585-0llgr357	145	3	of	of	IN
cord-017585-0llgr357	145	4	peptidase	peptidase	NN
cord-017585-0llgr357	145	5	inhibitors	inhibitor	NNS
cord-017585-0llgr357	145	6	on	on	IN
cord-017585-0llgr357	145	7	the	the	DT
cord-017585-0llgr357	145	8	formation	formation	NN
cord-017585-0llgr357	145	9	of	of	IN
cord-017585-0llgr357	145	10	Ang	Ang	NNP
cord-017585-0llgr357	145	11	II	II	NNP
cord-017585-0llgr357	145	12	metabolites	metabolite	NNS
cord-017585-0llgr357	145	13	include	include	VBP
cord-017585-0llgr357	145	14	:	:	:
cord-017585-0llgr357	145	15	AP	AP	NNP
cord-017585-0llgr357	145	16	,	,	,
cord-017585-0llgr357	145	17	amniopeptidase	amniopeptidase	NN
cord-017585-0llgr357	145	18	(	(	-LRB-
cord-017585-0llgr357	145	19	amastatin	amastatin	UH
cord-017585-0llgr357	145	20	,	,	,
cord-017585-0llgr357	145	21	bestatin	bestatin	NNP
cord-017585-0llgr357	145	22	)	)	-RRB-
cord-017585-0llgr357	145	23	;	;	:
cord-017585-0llgr357	145	24	CHY	CHY	NNP
cord-017585-0llgr357	145	25	,	,	,
cord-017585-0llgr357	145	26	chymase	chymase	NNP
cord-017585-0llgr357	145	27	,	,	,
cord-017585-0llgr357	145	28	carboxypeptidase	carboxypeptidase	NN
cord-017585-0llgr357	145	29	A	a	NN
cord-017585-0llgr357	145	30	(	(	-LRB-
cord-017585-0llgr357	145	31	chymostatin	chymostatin	NN
cord-017585-0llgr357	145	32	,	,	,
cord-017585-0llgr357	145	33	benzyl	benzyl	NN
cord-017585-0llgr357	145	34	succinate	succinate	NNP
cord-017585-0llgr357	145	35	)	)	-RRB-
cord-017585-0llgr357	145	36	;	;	:
cord-017585-0llgr357	145	37	CY	CY	NNP
cord-017585-0llgr357	145	38	,	,	,
cord-017585-0llgr357	145	39	cysteine	cysteine	NN
cord-017585-0llgr357	145	40	protease	protease	NN
cord-017585-0llgr357	145	41	(	(	-LRB-
cord-017585-0llgr357	145	42	PCMB	PCMB	NNP
cord-017585-0llgr357	145	43	)	)	-RRB-
cord-017585-0llgr357	145	44	;	;	:
cord-017585-0llgr357	145	45	NEP	NEP	NNP
cord-017585-0llgr357	145	46	,	,	,
cord-017585-0llgr357	145	47	neprilysin	neprilysin	NNP
cord-017585-0llgr357	145	48	(	(	-LRB-
cord-017585-0llgr357	145	49	SCH3977	SCH3977	NNP
cord-017585-0llgr357	145	50	)	)	-RRB-
cord-017585-0llgr357	145	51	,	,	,
cord-017585-0llgr357	145	52	ACE	ACE	NNP
cord-017585-0llgr357	145	53	,	,	,
cord-017585-0llgr357	145	54	angiotensin	angiotensin	NN
cord-017585-0llgr357	145	55	converting	convert	VBG
cord-017585-0llgr357	145	56	enzyme	enzyme	NN
cord-017585-0llgr357	145	57	(	(	-LRB-
cord-017585-0llgr357	145	58	lisinopril	lisinopril	NNP
cord-017585-0llgr357	145	59	)	)	-RRB-
cord-017585-0llgr357	145	60	;	;	:
cord-017585-0llgr357	145	61	ACE2	ACE2	NNP
cord-017585-0llgr357	145	62	(	(	-LRB-
cord-017585-0llgr357	145	63	MLN-4760	MLN-4760	NNP
cord-017585-0llgr357	145	64	)	)	-RRB-
cord-017585-0llgr357	145	65	.	.	.
cord-017585-0llgr357	146	1	Data	datum	NNS
cord-017585-0llgr357	146	2	are	be	VBP
cord-017585-0llgr357	146	3	n	n	NN
cord-017585-0llgr357	146	4	=	=	SYM
cord-017585-0llgr357	146	5	4	4	CD
cord-017585-0llgr357	146	6	,	,	,
cord-017585-0llgr357	146	7	mean	mean	JJ
cord-017585-0llgr357	146	8	±	±	NNP
cord-017585-0llgr357	146	9	SEM	SEM	NNP
cord-017585-0llgr357	146	10	implications	implication	NNS
cord-017585-0llgr357	146	11	on	on	IN
cord-017585-0llgr357	146	12	the	the	DT
cord-017585-0llgr357	146	13	role	role	NN
cord-017585-0llgr357	146	14	of	of	IN
cord-017585-0llgr357	146	15	ACE	ACE	NNP
cord-017585-0llgr357	146	16	as	as	RB
cord-017585-0llgr357	146	17	well	well	RB
cord-017585-0llgr357	146	18	,	,	,
cord-017585-0llgr357	146	19	particularly	particularly	RB
cord-017585-0llgr357	146	20	whether	whether	IN
cord-017585-0llgr357	146	21	ACE	ACE	NNP
cord-017585-0llgr357	146	22	is	be	VBZ
cord-017585-0llgr357	146	23	involved	involve	VBN
cord-017585-0llgr357	146	24	in	in	IN
cord-017585-0llgr357	146	25	the	the	DT
cord-017585-0llgr357	146	26	formation	formation	NN
cord-017585-0llgr357	146	27	or	or	CC
cord-017585-0llgr357	146	28	degradation	degradation	NN
cord-017585-0llgr357	146	29	of	of	IN
cord-017585-0llgr357	146	30	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	146	31	-	-	HYPH
cord-017585-0llgr357	146	32	7	7	CD
cord-017585-0llgr357	146	33	)	)	-RRB-
cord-017585-0llgr357	147	1	Chappell	Chappell	NNP
cord-017585-0llgr357	147	2	et	et	NNP
cord-017585-0llgr357	147	3	al	al	NNP
cord-017585-0llgr357	147	4	2000	2000	CD
cord-017585-0llgr357	147	5	;	;	:
cord-017585-0llgr357	147	6	Yamada	Yamada	NNP
cord-017585-0llgr357	147	7	et	et	NNP
cord-017585-0llgr357	147	8	al	al	NNP
cord-017585-0llgr357	147	9	1998	1998	CD
cord-017585-0llgr357	147	10	)	)	-RRB-
cord-017585-0llgr357	147	11	.	.	.
cord-017585-0llgr357	148	1	Although	although	IN
cord-017585-0llgr357	148	2	Campbell	Campbell	NNP
cord-017585-0llgr357	148	3	and	and	CC
cord-017585-0llgr357	148	4	colleague	colleague	NN
cord-017585-0llgr357	148	5	demonstrate	demonstrate	VBP
cord-017585-0llgr357	148	6	significant	significant	JJ
cord-017585-0llgr357	148	7	quantities	quantity	NNS
cord-017585-0llgr357	148	8	of	of	IN
cord-017585-0llgr357	148	9	endogenous	endogenous	JJ
cord-017585-0llgr357	148	10	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	148	11	-	-	HYPH
cord-017585-0llgr357	148	12	9	9	CD
cord-017585-0llgr357	148	13	)	)	-RRB-
cord-017585-0llgr357	148	14	in	in	IN
cord-017585-0llgr357	148	15	the	the	DT
cord-017585-0llgr357	148	16	rat	rat	NN
cord-017585-0llgr357	148	17	kidney	kidney	NN
cord-017585-0llgr357	148	18	(	(	-LRB-
cord-017585-0llgr357	148	19	Campbell	Campbell	NNP
cord-017585-0llgr357	148	20	et	et	NNP
cord-017585-0llgr357	148	21	al	al	NNP
cord-017585-0llgr357	148	22	1991	1991	CD
cord-017585-0llgr357	148	23	)	)	-RRB-
cord-017585-0llgr357	148	24	,	,	,
cord-017585-0llgr357	148	25	chronic	chronic	JJ
cord-017585-0llgr357	148	26	ACE	ace	NN
cord-017585-0llgr357	148	27	inhibition	inhibition	NN
cord-017585-0llgr357	148	28	or	or	CC
cord-017585-0llgr357	148	29	combined	combine	VBN
cord-017585-0llgr357	149	1	ACE	ACE	NNP
cord-017585-0llgr357	149	2	/	/	SYM
cord-017585-0llgr357	149	3	AT	at	IN
cord-017585-0llgr357	149	4	1	1	CD
cord-017585-0llgr357	149	5	blockade	blockade	NN
cord-017585-0llgr357	149	6	(	(	-LRB-
cord-017585-0llgr357	149	7	Chappell	Chappell	NNP
cord-017585-0llgr357	149	8	,	,	,
cord-017585-0llgr357	149	9	unpublished	unpublished	JJ
cord-017585-0llgr357	149	10	observations	observation	NNS
cord-017585-0llgr357	149	11	)	)	-RRB-
cord-017585-0llgr357	149	12	did	do	VBD
cord-017585-0llgr357	149	13	not	not	RB
cord-017585-0llgr357	149	14	attenuate	attenuate	VB
cord-017585-0llgr357	149	15	renal	renal	JJ
cord-017585-0llgr357	149	16	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	149	17	-	-	HYPH
cord-017585-0llgr357	149	18	7	7	CD
cord-017585-0llgr357	149	19	)	)	-RRB-
cord-017585-0llgr357	149	20	levels	level	NNS
cord-017585-0llgr357	149	21	in	in	IN
cord-017585-0llgr357	149	22	the	the	DT
cord-017585-0llgr357	149	23	rat	rat	NN
cord-017585-0llgr357	149	24	.	.	.
cord-017585-0llgr357	150	1	In	in	IN
cord-017585-0llgr357	150	2	addition	addition	NN
cord-017585-0llgr357	150	3	,	,	,
cord-017585-0llgr357	150	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	150	5	-	-	HYPH
cord-017585-0llgr357	150	6	7	7	CD
cord-017585-0llgr357	150	7	)	)	-RRB-
cord-017585-0llgr357	150	8	levels	level	NNS
cord-017585-0llgr357	150	9	within	within	IN
cord-017585-0llgr357	150	10	the	the	DT
cord-017585-0llgr357	150	11	kidney	kidney	NN
cord-017585-0llgr357	150	12	were	be	VBD
cord-017585-0llgr357	150	13	maintained	maintain	VBN
cord-017585-0llgr357	150	14	in	in	IN
cord-017585-0llgr357	150	15	tissue	tissue	NN
cord-017585-0llgr357	150	16	ACE	ace	NN
cord-017585-0llgr357	150	17	knockout	knockout	NN
cord-017585-0llgr357	150	18	mice	mouse	NNS
cord-017585-0llgr357	151	1	(	(	-LRB-
cord-017585-0llgr357	151	2	Modrall	Modrall	NNP
cord-017585-0llgr357	151	3	et	et	NNP
cord-017585-0llgr357	151	4	al	al	NNP
cord-017585-0llgr357	151	5	2003	2003	CD
cord-017585-0llgr357	151	6	)	)	-RRB-
cord-017585-0llgr357	151	7	.	.	.
cord-017585-0llgr357	152	1	Thus	thus	RB
cord-017585-0llgr357	152	2	,	,	,
cord-017585-0llgr357	152	3	these	these	DT
cord-017585-0llgr357	152	4	in	in	IN
cord-017585-0llgr357	152	5	vivo	vivo	NNP
cord-017585-0llgr357	152	6	studies	study	NNS
cord-017585-0llgr357	152	7	do	do	VBP
cord-017585-0llgr357	152	8	not	not	RB
cord-017585-0llgr357	152	9	strongly	strongly	RB
cord-017585-0llgr357	152	10	support	support	VB
cord-017585-0llgr357	152	11	an	an	DT
cord-017585-0llgr357	152	12	ACE2-ACE	ACE2-ACE	NNP
cord-017585-0llgr357	152	13	cascade	cascade	NN
cord-017585-0llgr357	152	14	leading	lead	VBG
cord-017585-0llgr357	152	15	to	to	IN
cord-017585-0llgr357	152	16	the	the	DT
cord-017585-0llgr357	152	17	formation	formation	NN
cord-017585-0llgr357	152	18	of	of	IN
cord-017585-0llgr357	152	19	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	152	20	-	-	HYPH
cord-017585-0llgr357	152	21	9	9	CD
cord-017585-0llgr357	152	22	)	)	-RRB-
cord-017585-0llgr357	152	23	and	and	CC
cord-017585-0llgr357	152	24	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	152	25	-	-	HYPH
cord-017585-0llgr357	152	26	7	7	CD
cord-017585-0llgr357	152	27	)	)	-RRB-
cord-017585-0llgr357	152	28	in	in	IN
cord-017585-0llgr357	152	29	the	the	DT
cord-017585-0llgr357	152	30	kidney	kidney	NN
cord-017585-0llgr357	152	31	.	.	.
cord-017585-0llgr357	153	1	The	the	DT
cord-017585-0llgr357	153	2	molecular	molecular	JJ
cord-017585-0llgr357	153	3	studies	study	NNS
cord-017585-0llgr357	153	4	utilizing	utilize	VBG
cord-017585-0llgr357	153	5	ACE2	ACE2	NNP
cord-017585-0llgr357	153	6	knockout	knockout	NN
cord-017585-0llgr357	153	7	mice	mouse	NNS
cord-017585-0llgr357	153	8	provide	provide	VBP
cord-017585-0llgr357	153	9	additional	additional	JJ
cord-017585-0llgr357	153	10	evidence	evidence	NN
cord-017585-0llgr357	153	11	for	for	IN
cord-017585-0llgr357	153	12	the	the	DT
cord-017585-0llgr357	153	13	enzyme	enzyme	NN
cord-017585-0llgr357	153	14	's	's	POS
cord-017585-0llgr357	153	15	role	role	NN
cord-017585-0llgr357	153	16	to	to	TO
cord-017585-0llgr357	153	17	balance	balance	VB
cord-017585-0llgr357	153	18	the	the	DT
cord-017585-0llgr357	153	19	expression	expression	NN
cord-017585-0llgr357	153	20	of	of	IN
cord-017585-0llgr357	153	21	Ang	Ang	NNP
cord-017585-0llgr357	153	22	II	II	NNP
cord-017585-0llgr357	153	23	and	and	CC
cord-017585-0llgr357	153	24	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	153	25	-	-	HYPH
cord-017585-0llgr357	153	26	7	7	CD
cord-017585-0llgr357	153	27	)	)	-RRB-
cord-017585-0llgr357	153	28	.	.	.
cord-017585-0llgr357	154	1	We	-PRON-	PRP
cord-017585-0llgr357	154	2	originally	originally	RB
cord-017585-0llgr357	154	3	showed	show	VBD
cord-017585-0llgr357	154	4	that	that	IN
cord-017585-0llgr357	154	5	ACE2	ACE2	NNP
cord-017585-0llgr357	154	6	null	null	JJ
cord-017585-0llgr357	154	7	mice	mouse	NNS
cord-017585-0llgr357	154	8	exhibit	exhibit	VBP
cord-017585-0llgr357	154	9	higher	high	JJR
cord-017585-0llgr357	154	10	circulating	circulating	NN
cord-017585-0llgr357	154	11	and	and	CC
cord-017585-0llgr357	154	12	tissue	tissue	NN
cord-017585-0llgr357	154	13	levels	level	NNS
cord-017585-0llgr357	154	14	of	of	IN
cord-017585-0llgr357	154	15	Ang	Ang	NNP
cord-017585-0llgr357	154	16	II	II	NNP
cord-017585-0llgr357	154	17	.	.	.
cord-017585-0llgr357	155	1	Indeed	indeed	RB
cord-017585-0llgr357	155	2	,	,	,
cord-017585-0llgr357	155	3	the	the	DT
cord-017585-0llgr357	155	4	increased	increase	VBN
cord-017585-0llgr357	155	5	ratio	ratio	NN
cord-017585-0llgr357	155	6	of	of	IN
cord-017585-0llgr357	155	7	renal	renal	JJ
cord-017585-0llgr357	155	8	Ang	Ang	NNP
cord-017585-0llgr357	155	9	II	II	NNP
cord-017585-0llgr357	155	10	to	to	IN
cord-017585-0llgr357	155	11	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	155	12	-	-	HYPH
cord-017585-0llgr357	155	13	7	7	CD
cord-017585-0llgr357	155	14	)	)	-RRB-
cord-017585-0llgr357	155	15	may	may	MD
cord-017585-0llgr357	155	16	contribute	contribute	VB
cord-017585-0llgr357	155	17	to	to	IN
cord-017585-0llgr357	155	18	the	the	DT
cord-017585-0llgr357	155	19	renal	renal	JJ
cord-017585-0llgr357	155	20	pathologies	pathology	NNS
cord-017585-0llgr357	155	21	observed	observe	VBN
cord-017585-0llgr357	155	22	in	in	IN
cord-017585-0llgr357	155	23	older	old	JJR
cord-017585-0llgr357	155	24	ACE2	ACE2	NNP
cord-017585-0llgr357	156	1	null	null	JJ
cord-017585-0llgr357	156	2	mice	mouse	NNS
cord-017585-0llgr357	157	1	(	(	-LRB-
cord-017585-0llgr357	157	2	Oudit	Oudit	NNP
cord-017585-0llgr357	157	3	et	et	NNP
cord-017585-0llgr357	157	4	al	al	NNP
cord-017585-0llgr357	157	5	2006	2006	CD
cord-017585-0llgr357	157	6	)	)	-RRB-
cord-017585-0llgr357	157	7	.	.	.
cord-017585-0llgr357	158	1	Furthermore	furthermore	RB
cord-017585-0llgr357	158	2	,	,	,
cord-017585-0llgr357	158	3	the	the	DT
cord-017585-0llgr357	158	4	incidence	incidence	NN
cord-017585-0llgr357	158	5	of	of	IN
cord-017585-0llgr357	158	6	glomerulosclerosis	glomerulosclerosis	NN
cord-017585-0llgr357	158	7	and	and	CC
cord-017585-0llgr357	158	8	proteinuria	proteinuria	NN
cord-017585-0llgr357	158	9	in	in	IN
cord-017585-0llgr357	158	10	the	the	DT
cord-017585-0llgr357	158	11	male	male	JJ
cord-017585-0llgr357	158	12	mice	mouse	NNS
cord-017585-0llgr357	158	13	was	be	VBD
cord-017585-0llgr357	158	14	markedly	markedly	RB
cord-017585-0llgr357	158	15	attenuated	attenuate	VBN
cord-017585-0llgr357	158	16	by	by	IN
cord-017585-0llgr357	158	17	AT	at	NN
cord-017585-0llgr357	158	18	1	1	CD
cord-017585-0llgr357	158	19	receptor	receptor	NN
cord-017585-0llgr357	158	20	blockade	blockade	NN
cord-017585-0llgr357	158	21	.	.	.
cord-017585-0llgr357	159	1	Several	several	JJ
cord-017585-0llgr357	159	2	hypertensive	hypertensive	JJ
cord-017585-0llgr357	159	3	models	model	NNS
cord-017585-0llgr357	159	4	including	include	VBG
cord-017585-0llgr357	159	5	the	the	DT
cord-017585-0llgr357	159	6	spontaneously	spontaneously	RB
cord-017585-0llgr357	159	7	hypertensive	hypertensive	JJ
cord-017585-0llgr357	159	8	rat	rat	NN
cord-017585-0llgr357	159	9	(	(	-LRB-
cord-017585-0llgr357	159	10	SHR	SHR	NNP
cord-017585-0llgr357	159	11	)	)	-RRB-
cord-017585-0llgr357	159	12	,	,	,
cord-017585-0llgr357	159	13	stroke	stroke	NN
cord-017585-0llgr357	159	14	-	-	HYPH
cord-017585-0llgr357	159	15	prone	prone	JJ
cord-017585-0llgr357	159	16	SHR	SHR	NNP
cord-017585-0llgr357	159	17	and	and	CC
cord-017585-0llgr357	159	18	Sabra	Sabra	NNP
cord-017585-0llgr357	159	19	salt	salt	NN
cord-017585-0llgr357	159	20	sensitive	sensitive	JJ
cord-017585-0llgr357	159	21	rat	rat	NN
cord-017585-0llgr357	159	22	exhibit	exhibit	NN
cord-017585-0llgr357	159	23	lower	low	JJR
cord-017585-0llgr357	159	24	mRNA	mRNA	NNP
cord-017585-0llgr357	159	25	levels	level	NNS
cord-017585-0llgr357	159	26	and	and	CC
cord-017585-0llgr357	159	27	protein	protein	NN
cord-017585-0llgr357	159	28	expression	expression	NN
cord-017585-0llgr357	159	29	for	for	IN
cord-017585-0llgr357	159	30	ACE2	ACE2	NNP
cord-017585-0llgr357	159	31	in	in	IN
cord-017585-0llgr357	159	32	the	the	DT
cord-017585-0llgr357	159	33	kidney	kidney	NN
cord-017585-0llgr357	159	34	than	than	IN
cord-017585-0llgr357	159	35	normotensive	normotensive	NNP
cord-017585-0llgr357	159	36	controls	control	VBZ
cord-017585-0llgr357	159	37	Zhong	Zhong	NNP
cord-017585-0llgr357	159	38	et	et	NNP
cord-017585-0llgr357	159	39	al	al	NNP
cord-017585-0llgr357	159	40	2004	2004	CD
cord-017585-0llgr357	159	41	)	)	-RRB-
cord-017585-0llgr357	159	42	,	,	,
cord-017585-0llgr357	159	43	as	as	RB
cord-017585-0llgr357	159	44	well	well	RB
cord-017585-0llgr357	159	45	as	as	IN
cord-017585-0llgr357	159	46	human	human	JJ
cord-017585-0llgr357	159	47	prehypertensives	prehypertensive	NNS
cord-017585-0llgr357	159	48	(	(	-LRB-
cord-017585-0llgr357	159	49	Keidar	Keidar	NNP
cord-017585-0llgr357	159	50	et	et	NNP
cord-017585-0llgr357	159	51	al	al	NNP
cord-017585-0llgr357	159	52	2006	2006	CD
cord-017585-0llgr357	159	53	)	)	-RRB-
cord-017585-0llgr357	159	54	.	.	.
cord-017585-0llgr357	160	1	Tikellis	Tikellis	NNP
cord-017585-0llgr357	160	2	and	and	CC
cord-017585-0llgr357	160	3	colleagues	colleague	NNS
cord-017585-0llgr357	160	4	find	find	VBP
cord-017585-0llgr357	160	5	that	that	IN
cord-017585-0llgr357	160	6	renal	renal	JJ
cord-017585-0llgr357	160	7	ACE2	ACE2	NNP
cord-017585-0llgr357	160	8	expression	expression	NN
cord-017585-0llgr357	160	9	is	be	VBZ
cord-017585-0llgr357	160	10	actually	actually	RB
cord-017585-0llgr357	160	11	higher	high	JJR
cord-017585-0llgr357	160	12	in	in	IN
cord-017585-0llgr357	160	13	the	the	DT
cord-017585-0llgr357	160	14	SHR	SHR	NNP
cord-017585-0llgr357	160	15	than	than	IN
cord-017585-0llgr357	160	16	WKY	WKY	NNP
cord-017585-0llgr357	160	17	normotensive	normotensive	NNP
cord-017585-0llgr357	160	18	controls	control	NNS
cord-017585-0llgr357	160	19	at	at	IN
cord-017585-0llgr357	160	20	day	day	NN
cord-017585-0llgr357	160	21	one	one	CD
cord-017585-0llgr357	160	22	following	follow	VBG
cord-017585-0llgr357	160	23	birth	birth	NN
cord-017585-0llgr357	160	24	,	,	,
cord-017585-0llgr357	160	25	similar	similar	JJ
cord-017585-0llgr357	160	26	at	at	IN
cord-017585-0llgr357	160	27	42	42	CD
cord-017585-0llgr357	160	28	days	day	NNS
cord-017585-0llgr357	160	29	and	and	CC
cord-017585-0llgr357	160	30	then	then	RB
cord-017585-0llgr357	160	31	dramatically	dramatically	RB
cord-017585-0llgr357	160	32	declines	decline	VBZ
cord-017585-0llgr357	160	33	in	in	IN
cord-017585-0llgr357	160	34	adult	adult	NN
cord-017585-0llgr357	160	35	SHR	SHR	NNP
cord-017585-0llgr357	160	36	by	by	IN
cord-017585-0llgr357	160	37	80	80	CD
cord-017585-0llgr357	160	38	days	day	NNS
cord-017585-0llgr357	161	1	(	(	-LRB-
cord-017585-0llgr357	161	2	Tikellis	Tikellis	NNP
cord-017585-0llgr357	161	3	et	et	FW
cord-017585-0llgr357	161	4	al	al	NNP
cord-017585-0llgr357	161	5	2006	2006	CD
cord-017585-0llgr357	161	6	)	)	-RRB-
cord-017585-0llgr357	161	7	.	.	.
cord-017585-0llgr357	162	1	ACE	ace	NN
cord-017585-0llgr357	162	2	activity	activity	NN
cord-017585-0llgr357	162	3	,	,	,
cord-017585-0llgr357	162	4	however	however	RB
cord-017585-0llgr357	162	5	,	,	,
cord-017585-0llgr357	162	6	was	be	VBD
cord-017585-0llgr357	162	7	markedly	markedly	RB
cord-017585-0llgr357	162	8	lower	low	JJR
cord-017585-0llgr357	162	9	in	in	IN
cord-017585-0llgr357	162	10	the	the	DT
cord-017585-0llgr357	162	11	SHR	SHR	NNP
cord-017585-0llgr357	162	12	kidney	kidney	NN
cord-017585-0llgr357	162	13	at	at	IN
cord-017585-0llgr357	162	14	all	all	DT
cord-017585-0llgr357	162	15	time	time	NN
cord-017585-0llgr357	162	16	points	point	NNS
cord-017585-0llgr357	162	17	measured	measure	VBN
cord-017585-0llgr357	162	18	and	and	CC
cord-017585-0llgr357	162	19	declined	decline	VBD
cord-017585-0llgr357	162	20	in	in	IN
cord-017585-0llgr357	162	21	both	both	DT
cord-017585-0llgr357	162	22	strains	strain	NNS
cord-017585-0llgr357	162	23	at	at	IN
cord-017585-0llgr357	162	24	80	80	CD
cord-017585-0llgr357	162	25	days	day	NNS
cord-017585-0llgr357	162	26	.	.	.
cord-017585-0llgr357	163	1	Apart	apart	RB
cord-017585-0llgr357	163	2	from	from	IN
cord-017585-0llgr357	163	3	the	the	DT
cord-017585-0llgr357	163	4	interesting	interesting	JJ
cord-017585-0llgr357	163	5	pattern	pattern	NN
cord-017585-0llgr357	163	6	of	of	IN
cord-017585-0llgr357	163	7	development	development	NN
cord-017585-0llgr357	163	8	for	for	IN
cord-017585-0llgr357	163	9	ACE2	ACE2	NNP
cord-017585-0llgr357	163	10	in	in	IN
cord-017585-0llgr357	163	11	the	the	DT
cord-017585-0llgr357	163	12	kidney	kidney	NN
cord-017585-0llgr357	163	13	,	,	,
cord-017585-0llgr357	163	14	these	these	DT
cord-017585-0llgr357	163	15	data	datum	NNS
cord-017585-0llgr357	163	16	emphasize	emphasize	VBP
cord-017585-0llgr357	163	17	the	the	DT
cord-017585-0llgr357	163	18	need	need	NN
cord-017585-0llgr357	163	19	to	to	TO
cord-017585-0llgr357	163	20	at	at	IN
cord-017585-0llgr357	163	21	least	least	JJS
cord-017585-0llgr357	163	22	consider	consider	VB
cord-017585-0llgr357	163	23	alterations	alteration	NNS
cord-017585-0llgr357	163	24	in	in	IN
cord-017585-0llgr357	163	25	both	both	CC
cord-017585-0llgr357	163	26	ACE	ACE	NNP
cord-017585-0llgr357	163	27	and	and	CC
cord-017585-0llgr357	163	28	ACE2	ACE2	NNP
cord-017585-0llgr357	163	29	in	in	IN
cord-017585-0llgr357	163	30	characterizing	characterize	VBG
cord-017585-0llgr357	163	31	the	the	DT
cord-017585-0llgr357	163	32	functional	functional	JJ
cord-017585-0llgr357	163	33	output	output	NN
cord-017585-0llgr357	163	34	of	of	IN
cord-017585-0llgr357	163	35	the	the	DT
cord-017585-0llgr357	163	36	RAAS	raa	NNS
cord-017585-0llgr357	163	37	.	.	.
cord-017585-0llgr357	164	1	Moreover	moreover	RB
cord-017585-0llgr357	164	2	,	,	,
cord-017585-0llgr357	164	3	parallel	parallel	JJ
cord-017585-0llgr357	164	4	studies	study	NNS
cord-017585-0llgr357	164	5	to	to	TO
cord-017585-0llgr357	164	6	document	document	VB
cord-017585-0llgr357	164	7	the	the	DT
cord-017585-0llgr357	164	8	changes	change	NNS
cord-017585-0llgr357	164	9	in	in	IN
cord-017585-0llgr357	164	10	renal	renal	JJ
cord-017585-0llgr357	164	11	Ang	Ang	NNP
cord-017585-0llgr357	164	12	II	II	NNP
cord-017585-0llgr357	164	13	and	and	CC
cord-017585-0llgr357	164	14	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	164	15	-	-	HYPH
cord-017585-0llgr357	164	16	7	7	CD
cord-017585-0llgr357	164	17	)	)	-RRB-
cord-017585-0llgr357	164	18	during	during	IN
cord-017585-0llgr357	164	19	this	this	DT
cord-017585-0llgr357	164	20	developmental	developmental	JJ
cord-017585-0llgr357	164	21	period	period	NN
cord-017585-0llgr357	164	22	are	be	VBP
cord-017585-0llgr357	164	23	critical	critical	JJ
cord-017585-0llgr357	164	24	to	to	TO
cord-017585-0llgr357	164	25	establish	establish	VB
cord-017585-0llgr357	164	26	the	the	DT
cord-017585-0llgr357	164	27	relevance	relevance	NN
cord-017585-0llgr357	164	28	to	to	IN
cord-017585-0llgr357	164	29	altered	alter	VBN
cord-017585-0llgr357	164	30	ACE	ACE	NNP
cord-017585-0llgr357	164	31	and	and	CC
cord-017585-0llgr357	164	32	ACE2	ACE2	NNP
cord-017585-0llgr357	164	33	.	.	.
cord-017585-0llgr357	165	1	It	-PRON-	PRP
cord-017585-0llgr357	165	2	is	be	VBZ
cord-017585-0llgr357	165	3	clear	clear	JJ
cord-017585-0llgr357	165	4	that	that	IN
cord-017585-0llgr357	165	5	not	not	RB
cord-017585-0llgr357	165	6	all	all	DT
cord-017585-0llgr357	165	7	hypertensive	hypertensive	JJ
cord-017585-0llgr357	165	8	models	model	NNS
cord-017585-0llgr357	165	9	exhibit	exhibit	VBP
cord-017585-0llgr357	165	10	reduced	reduce	VBN
cord-017585-0llgr357	165	11	ACE2	ACE2	NNP
cord-017585-0llgr357	165	12	in	in	IN
cord-017585-0llgr357	165	13	the	the	DT
cord-017585-0llgr357	165	14	kidney	kidney	NN
cord-017585-0llgr357	165	15	.	.	.
cord-017585-0llgr357	166	1	Our	-PRON-	PRP$
cord-017585-0llgr357	166	2	studies	study	NNS
cord-017585-0llgr357	166	3	in	in	IN
cord-017585-0llgr357	166	4	the	the	DT
cord-017585-0llgr357	166	5	male	male	NN
cord-017585-0llgr357	166	6	mRen2.Lewis	mren2.lewis	IN
cord-017585-0llgr357	166	7	rat	rat	NN
cord-017585-0llgr357	166	8	,	,	,
cord-017585-0llgr357	166	9	a	a	DT
cord-017585-0llgr357	166	10	model	model	NN
cord-017585-0llgr357	166	11	of	of	IN
cord-017585-0llgr357	166	12	tissue	tissue	NN
cord-017585-0llgr357	166	13	renin	renin	NN
cord-017585-0llgr357	166	14	expression	expression	NN
cord-017585-0llgr357	166	15	with	with	IN
cord-017585-0llgr357	166	16	increased	increase	VBN
cord-017585-0llgr357	166	17	renal	renal	JJ
cord-017585-0llgr357	166	18	Ang	Ang	NNP
cord-017585-0llgr357	166	19	II	II	NNP
cord-017585-0llgr357	166	20	,	,	,
cord-017585-0llgr357	166	21	found	find	VBD
cord-017585-0llgr357	166	22	no	no	DT
cord-017585-0llgr357	166	23	difference	difference	NN
cord-017585-0llgr357	166	24	in	in	IN
cord-017585-0llgr357	166	25	renal	renal	JJ
cord-017585-0llgr357	166	26	cortical	cortical	JJ
cord-017585-0llgr357	166	27	ACE2	ACE2	NNP
cord-017585-0llgr357	166	28	activity	activity	NN
cord-017585-0llgr357	166	29	as	as	IN
cord-017585-0llgr357	166	30	compared	compare	VBN
cord-017585-0llgr357	166	31	to	to	IN
cord-017585-0llgr357	166	32	the	the	DT
cord-017585-0llgr357	166	33	normotensive	normotensive	JJ
cord-017585-0llgr357	166	34	Lewis	Lewis	NNP
cord-017585-0llgr357	166	35	strain	strain	NN
cord-017585-0llgr357	166	36	,	,	,
cord-017585-0llgr357	166	37	although	although	IN
cord-017585-0llgr357	166	38	cardiac	cardiac	JJ
cord-017585-0llgr357	166	39	activity	activity	NN
cord-017585-0llgr357	166	40	was	be	VBD
cord-017585-0llgr357	166	41	indeed	indeed	RB
cord-017585-0llgr357	166	42	lower	low	JJR
cord-017585-0llgr357	166	43	in	in	IN
cord-017585-0llgr357	166	44	the	the	DT
cord-017585-0llgr357	166	45	hypertensive	hypertensive	JJ
cord-017585-0llgr357	166	46	rats	rat	NNS
cord-017585-0llgr357	166	47	Ferrario	Ferrario	NNP
cord-017585-0llgr357	166	48	et	et	NNP
cord-017585-0llgr357	166	49	al	al	NNP
cord-017585-0llgr357	166	50	2005b	2005b	CD
cord-017585-0llgr357	166	51	;	;	:
cord-017585-0llgr357	166	52	Pendergrass	Pendergrass	NNP
cord-017585-0llgr357	166	53	et	et	NNP
cord-017585-0llgr357	166	54	al	al	NNP
cord-017585-0llgr357	166	55	2006	2006	CD
cord-017585-0llgr357	166	56	)	)	-RRB-
cord-017585-0llgr357	166	57	.	.	.
cord-017585-0llgr357	167	1	Chronic	chronic	NN
cord-017585-0llgr357	167	2	blockade	blockade	NN
cord-017585-0llgr357	167	3	with	with	IN
cord-017585-0llgr357	167	4	either	either	CC
cord-017585-0llgr357	167	5	an	an	DT
cord-017585-0llgr357	167	6	ACE	ace	NN
cord-017585-0llgr357	167	7	inhibitor	inhibitor	NN
cord-017585-0llgr357	167	8	or	or	CC
cord-017585-0llgr357	167	9	AT	at	IN
cord-017585-0llgr357	167	10	1	1	CD
cord-017585-0llgr357	167	11	antagonist	antagonist	NN
cord-017585-0llgr357	167	12	increased	increase	VBD
cord-017585-0llgr357	167	13	ACE2	ACE2	NNP
cord-017585-0llgr357	167	14	activity	activity	NN
cord-017585-0llgr357	167	15	in	in	IN
cord-017585-0llgr357	167	16	the	the	DT
cord-017585-0llgr357	167	17	kidneys	kidney	NNS
cord-017585-0llgr357	167	18	of	of	IN
cord-017585-0llgr357	167	19	both	both	CC
cord-017585-0llgr357	167	20	the	the	DT
cord-017585-0llgr357	167	21	mRen2.Lewis	mRen2.Lewis	NNPS
cord-017585-0llgr357	167	22	and	and	CC
cord-017585-0llgr357	167	23	Lewis	Lewis	NNP
cord-017585-0llgr357	167	24	rats	rat	NNS
cord-017585-0llgr357	167	25	,	,	,
cord-017585-0llgr357	167	26	but	but	CC
cord-017585-0llgr357	167	27	enzyme	enzyme	NN
cord-017585-0llgr357	167	28	activity	activity	NN
cord-017585-0llgr357	167	29	was	be	VBD
cord-017585-0llgr357	167	30	significantly	significantly	RB
cord-017585-0llgr357	167	31	higher	high	JJR
cord-017585-0llgr357	167	32	in	in	IN
cord-017585-0llgr357	167	33	the	the	DT
cord-017585-0llgr357	167	34	normotensive	normotensive	JJ
cord-017585-0llgr357	167	35	strain	strain	NN
cord-017585-0llgr357	167	36	following	follow	VBG
cord-017585-0llgr357	167	37	treatment	treatment	NN
cord-017585-0llgr357	167	38	.	.	.
cord-017585-0llgr357	168	1	This	this	DT
cord-017585-0llgr357	168	2	may	may	MD
cord-017585-0llgr357	168	3	reflect	reflect	VB
cord-017585-0llgr357	168	4	the	the	DT
cord-017585-0llgr357	168	5	situation	situation	NN
cord-017585-0llgr357	168	6	where	where	WRB
cord-017585-0llgr357	168	7	RAAS	RAAS	NNP
cord-017585-0llgr357	168	8	blockade	blockade	NN
cord-017585-0llgr357	168	9	does	do	VBZ
cord-017585-0llgr357	168	10	not	not	RB
cord-017585-0llgr357	168	11	completely	completely	RB
cord-017585-0llgr357	168	12	reverse	reverse	VB
cord-017585-0llgr357	168	13	the	the	DT
cord-017585-0llgr357	168	14	extent	extent	NN
cord-017585-0llgr357	168	15	of	of	IN
cord-017585-0llgr357	168	16	renal	renal	JJ
cord-017585-0llgr357	168	17	injury	injury	NN
cord-017585-0llgr357	168	18	in	in	IN
cord-017585-0llgr357	168	19	the	the	DT
cord-017585-0llgr357	168	20	male	male	JJ
cord-017585-0llgr357	168	21	mRen2.Lewis	mren2.lewis	NN
cord-017585-0llgr357	168	22	model	model	NN
cord-017585-0llgr357	168	23	.	.	.
cord-017585-0llgr357	169	1	In	in	IN
cord-017585-0llgr357	169	2	this	this	DT
cord-017585-0llgr357	169	3	regard	regard	NN
cord-017585-0llgr357	169	4	,	,	,
cord-017585-0llgr357	169	5	the	the	DT
cord-017585-0llgr357	169	6	reduced	reduce	VBN
cord-017585-0llgr357	169	7	ACE2	ACE2	NNP
cord-017585-0llgr357	169	8	and	and	CC
cord-017585-0llgr357	169	9	elevated	elevated	JJ
cord-017585-0llgr357	169	10	renal	renal	JJ
cord-017585-0llgr357	169	11	Ang	Ang	NNP
cord-017585-0llgr357	169	12	II	II	NNP
cord-017585-0llgr357	169	13	in	in	IN
cord-017585-0llgr357	169	14	the	the	DT
cord-017585-0llgr357	169	15	injured	injure	VBN
cord-017585-0llgr357	169	16	kidney	kidney	NN
cord-017585-0llgr357	169	17	of	of	IN
cord-017585-0llgr357	169	18	albumin	albumin	NN
cord-017585-0llgr357	169	19	-	-	HYPH
cord-017585-0llgr357	169	20	loaded	load	VBN
cord-017585-0llgr357	169	21	rats	rat	NNS
cord-017585-0llgr357	169	22	was	be	VBD
cord-017585-0llgr357	169	23	associated	associate	VBN
cord-017585-0llgr357	169	24	with	with	IN
cord-017585-0llgr357	169	25	increased	increase	VBN
cord-017585-0llgr357	169	26	NF	nf	NN
cord-017585-0llgr357	169	27	-	-	HYPH
cord-017585-0llgr357	169	28	B	b	NN
cord-017585-0llgr357	169	29	expression	expression	NN
cord-017585-0llgr357	169	30	(	(	-LRB-
cord-017585-0llgr357	169	31	Takase	Takase	NNP
cord-017585-0llgr357	169	32	et	et	FW
cord-017585-0llgr357	169	33	al	al	NNP
cord-017585-0llgr357	169	34	2005	2005	CD
cord-017585-0llgr357	169	35	)	)	-RRB-
cord-017585-0llgr357	169	36	.	.	.
cord-017585-0llgr357	170	1	In	in	IN
cord-017585-0llgr357	170	2	contrast	contrast	NN
cord-017585-0llgr357	170	3	,	,	,
cord-017585-0llgr357	170	4	ACE2	ACE2	NNP
cord-017585-0llgr357	170	5	and	and	CC
cord-017585-0llgr357	170	6	its	-PRON-	PRP$
cord-017585-0llgr357	170	7	product	product	NN
cord-017585-0llgr357	170	8	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	170	9	-	-	HYPH
cord-017585-0llgr357	170	10	7	7	CD
cord-017585-0llgr357	170	11	)	)	-RRB-
cord-017585-0llgr357	170	12	increase	increase	VB
cord-017585-0llgr357	170	13	in	in	IN
cord-017585-0llgr357	170	14	the	the	DT
cord-017585-0llgr357	170	15	kidney	kidney	NN
cord-017585-0llgr357	170	16	of	of	IN
cord-017585-0llgr357	170	17	the	the	DT
cord-017585-0llgr357	170	18	rat	rat	NN
cord-017585-0llgr357	170	19	during	during	IN
cord-017585-0llgr357	170	20	pregnancy	pregnancy	NN
cord-017585-0llgr357	170	21	.	.	.
cord-017585-0llgr357	171	1	It	-PRON-	PRP
cord-017585-0llgr357	171	2	is	be	VBZ
cord-017585-0llgr357	171	3	well	well	RB
cord-017585-0llgr357	171	4	known	know	VBN
cord-017585-0llgr357	171	5	that	that	IN
cord-017585-0llgr357	171	6	the	the	DT
cord-017585-0llgr357	171	7	RAAS	RAAS	NNP
cord-017585-0llgr357	171	8	is	be	VBZ
cord-017585-0llgr357	171	9	activated	activate	VBN
cord-017585-0llgr357	171	10	during	during	IN
cord-017585-0llgr357	171	11	pregnancy	pregnancy	NN
cord-017585-0llgr357	171	12	,	,	,
cord-017585-0llgr357	171	13	yet	yet	CC
cord-017585-0llgr357	171	14	blood	blood	NN
cord-017585-0llgr357	171	15	pressure	pressure	NN
cord-017585-0llgr357	171	16	is	be	VBZ
cord-017585-0llgr357	171	17	not	not	RB
cord-017585-0llgr357	171	18	altered	alter	VBN
cord-017585-0llgr357	171	19	in	in	IN
cord-017585-0llgr357	171	20	normal	normal	JJ
cord-017585-0llgr357	171	21	pregnancy	pregnancy	NN
cord-017585-0llgr357	171	22	,	,	,
cord-017585-0llgr357	171	23	and	and	CC
cord-017585-0llgr357	171	24	it	-PRON-	PRP
cord-017585-0llgr357	171	25	will	will	MD
cord-017585-0llgr357	171	26	be	be	VB
cord-017585-0llgr357	171	27	of	of	IN
cord-017585-0llgr357	171	28	interest	interest	NN
cord-017585-0llgr357	171	29	to	to	TO
cord-017585-0llgr357	171	30	determine	determine	VB
cord-017585-0llgr357	171	31	whether	whether	IN
cord-017585-0llgr357	171	32	ACE2	ACE2	NNP
cord-017585-0llgr357	171	33	expression	expression	NN
cord-017585-0llgr357	171	34	within	within	IN
cord-017585-0llgr357	171	35	the	the	DT
cord-017585-0llgr357	171	36	kidney	kidney	NN
cord-017585-0llgr357	171	37	is	be	VBZ
cord-017585-0llgr357	171	38	altered	alter	VBN
cord-017585-0llgr357	171	39	with	with	IN
cord-017585-0llgr357	171	40	pre	pre	JJ
cord-017585-0llgr357	171	41	-	-	JJ
cord-017585-0llgr357	171	42	eclampsia	eclampsia	JJ
cord-017585-0llgr357	171	43	.	.	.
cord-017585-0llgr357	172	1	Diabetic	diabetic	JJ
cord-017585-0llgr357	172	2	nephropathy	nephropathy	NN
cord-017585-0llgr357	172	3	is	be	VBZ
cord-017585-0llgr357	172	4	clearly	clearly	RB
cord-017585-0llgr357	172	5	dependent	dependent	JJ
cord-017585-0llgr357	172	6	on	on	IN
cord-017585-0llgr357	172	7	an	an	DT
cord-017585-0llgr357	172	8	activated	activate	VBN
cord-017585-0llgr357	172	9	RAAS	raa	NNS
cord-017585-0llgr357	172	10	and	and	CC
cord-017585-0llgr357	172	11	both	both	CC
cord-017585-0llgr357	172	12	ACE	ACE	NNP
cord-017585-0llgr357	172	13	inhibitors	inhibitor	NNS
cord-017585-0llgr357	172	14	and	and	CC
cord-017585-0llgr357	172	15	AT	at	IN
cord-017585-0llgr357	172	16	1	1	CD
cord-017585-0llgr357	172	17	receptor	receptor	NN
cord-017585-0llgr357	172	18	antagonists	antagonist	NNS
cord-017585-0llgr357	172	19	are	be	VBP
cord-017585-0llgr357	172	20	effective	effective	JJ
cord-017585-0llgr357	172	21	in	in	IN
cord-017585-0llgr357	172	22	attenuating	attenuate	VBG
cord-017585-0llgr357	172	23	the	the	DT
cord-017585-0llgr357	172	24	progression	progression	NN
cord-017585-0llgr357	172	25	of	of	IN
cord-017585-0llgr357	172	26	injury	injury	NN
cord-017585-0llgr357	172	27	.	.	.
cord-017585-0llgr357	173	1	Indeed	indeed	RB
cord-017585-0llgr357	173	2	,	,	,
cord-017585-0llgr357	173	3	the	the	DT
cord-017585-0llgr357	173	4	renal	renal	JJ
cord-017585-0llgr357	173	5	expression	expression	NN
cord-017585-0llgr357	173	6	of	of	IN
cord-017585-0llgr357	173	7	ACE2	ACE2	NNP
cord-017585-0llgr357	173	8	is	be	VBZ
cord-017585-0llgr357	173	9	reduced	reduce	VBN
cord-017585-0llgr357	173	10	in	in	IN
cord-017585-0llgr357	173	11	the	the	DT
cord-017585-0llgr357	173	12	proximal	proximal	JJ
cord-017585-0llgr357	173	13	tubules	tubule	NNS
cord-017585-0llgr357	173	14	of	of	IN
cord-017585-0llgr357	173	15	the	the	DT
cord-017585-0llgr357	173	16	streptozotocin	streptozotocin	NNS
cord-017585-0llgr357	173	17	-	-	HYPH
cord-017585-0llgr357	173	18	induced	induce	VBN
cord-017585-0llgr357	173	19	model	model	NN
cord-017585-0llgr357	173	20	of	of	IN
cord-017585-0llgr357	173	21	type	type	NN
cord-017585-0llgr357	173	22	I	-PRON-	PRP
cord-017585-0llgr357	173	23	diabetes	diabete	VBZ
cord-017585-0llgr357	174	1	(	(	-LRB-
cord-017585-0llgr357	174	2	Tikellis	Tikellis	NNP
cord-017585-0llgr357	174	3	et	et	FW
cord-017585-0llgr357	174	4	al	al	NNP
cord-017585-0llgr357	174	5	2003	2003	CD
cord-017585-0llgr357	175	1	;	;	:
cord-017585-0llgr357	175	2	Wysocki	Wysocki	NNP
cord-017585-0llgr357	175	3	et	et	NNP
cord-017585-0llgr357	175	4	al	al	NNP
cord-017585-0llgr357	175	5	2006	2006	CD
cord-017585-0llgr357	175	6	)	)	-RRB-
cord-017585-0llgr357	175	7	.	.	.
cord-017585-0llgr357	176	1	Moreover	moreover	RB
cord-017585-0llgr357	176	2	,	,	,
cord-017585-0llgr357	176	3	the	the	DT
cord-017585-0llgr357	176	4	attenuation	attenuation	NN
cord-017585-0llgr357	176	5	of	of	IN
cord-017585-0llgr357	176	6	renal	renal	JJ
cord-017585-0llgr357	176	7	injury	injury	NN
cord-017585-0llgr357	176	8	in	in	IN
cord-017585-0llgr357	176	9	this	this	DT
cord-017585-0llgr357	176	10	model	model	NN
cord-017585-0llgr357	176	11	by	by	IN
cord-017585-0llgr357	176	12	ACE	ace	NN
cord-017585-0llgr357	176	13	inhibition	inhibition	NN
cord-017585-0llgr357	176	14	is	be	VBZ
cord-017585-0llgr357	176	15	associated	associate	VBN
cord-017585-0llgr357	176	16	with	with	IN
cord-017585-0llgr357	176	17	increased	increase	VBN
cord-017585-0llgr357	176	18	ACE2	ACE2	NNP
cord-017585-0llgr357	176	19	expression	expression	NN
cord-017585-0llgr357	176	20	.	.	.
cord-017585-0llgr357	177	1	A	a	DT
cord-017585-0llgr357	177	2	protective	protective	JJ
cord-017585-0llgr357	177	3	role	role	NN
cord-017585-0llgr357	177	4	for	for	IN
cord-017585-0llgr357	177	5	renal	renal	JJ
cord-017585-0llgr357	177	6	ACE2	ACE2	NNP
cord-017585-0llgr357	177	7	is	be	VBZ
cord-017585-0llgr357	177	8	also	also	RB
cord-017585-0llgr357	177	9	evident	evident	JJ
cord-017585-0llgr357	177	10	from	from	IN
cord-017585-0llgr357	177	11	the	the	DT
cord-017585-0llgr357	177	12	findings	finding	NNS
cord-017585-0llgr357	177	13	that	that	WDT
cord-017585-0llgr357	177	14	chronic	chronic	JJ
cord-017585-0llgr357	177	15	ACE2	ACE2	NNP
cord-017585-0llgr357	177	16	inhibition	inhibition	NN
cord-017585-0llgr357	177	17	in	in	IN
cord-017585-0llgr357	177	18	the	the	DT
cord-017585-0llgr357	177	19	diabetic	diabetic	JJ
cord-017585-0llgr357	177	20	db	db	NNP
cord-017585-0llgr357	177	21	/	/	SYM
cord-017585-0llgr357	177	22	db	db	NNP
cord-017585-0llgr357	177	23	mice	mouse	NNS
cord-017585-0llgr357	177	24	exacerbates	exacerbate	VBZ
cord-017585-0llgr357	177	25	the	the	DT
cord-017585-0llgr357	177	26	extent	extent	NN
cord-017585-0llgr357	177	27	of	of	IN
cord-017585-0llgr357	177	28	albuminuria	albuminuria	NNS
cord-017585-0llgr357	177	29	almost	almost	RB
cord-017585-0llgr357	177	30	3-fold	3-fold	CD
cord-017585-0llgr357	177	31	.	.	.
cord-017585-0llgr357	178	1	Although	although	IN
cord-017585-0llgr357	178	2	angiotensin	angiotensin	NN
cord-017585-0llgr357	178	3	content	content	NN
cord-017585-0llgr357	178	4	was	be	VBD
cord-017585-0llgr357	178	5	not	not	RB
cord-017585-0llgr357	178	6	measured	measure	VBN
cord-017585-0llgr357	178	7	,	,	,
cord-017585-0llgr357	178	8	the	the	DT
cord-017585-0llgr357	178	9	db	db	NNP
cord-017585-0llgr357	178	10	/	/	SYM
cord-017585-0llgr357	178	11	db	db	NNP
cord-017585-0llgr357	178	12	mice	mouse	NNS
cord-017585-0llgr357	178	13	exhibited	exhibit	VBD
cord-017585-0llgr357	178	14	increased	increase	VBN
cord-017585-0llgr357	178	15	glomerular	glomerular	JJ
cord-017585-0llgr357	178	16	expression	expression	NN
cord-017585-0llgr357	178	17	of	of	IN
cord-017585-0llgr357	178	18	ACE	ace	NN
cord-017585-0llgr357	178	19	and	and	CC
cord-017585-0llgr357	178	20	reduced	reduce	VBD
cord-017585-0llgr357	178	21	ACE2	ACE2	NNP
cord-017585-0llgr357	178	22	as	as	IN
cord-017585-0llgr357	178	23	compared	compare	VBN
cord-017585-0llgr357	178	24	to	to	IN
cord-017585-0llgr357	178	25	the	the	DT
cord-017585-0llgr357	178	26	control	control	NN
cord-017585-0llgr357	178	27	db	db	NNP
cord-017585-0llgr357	178	28	/	/	SYM
cord-017585-0llgr357	178	29	dm	dm	NNP
cord-017585-0llgr357	178	30	mice	mouse	NNS
cord-017585-0llgr357	178	31	.	.	.
cord-017585-0llgr357	179	1	Interestingly	interestingly	RB
cord-017585-0llgr357	179	2	,	,	,
cord-017585-0llgr357	179	3	the	the	DT
cord-017585-0llgr357	179	4	localization	localization	NN
cord-017585-0llgr357	179	5	studies	study	NNS
cord-017585-0llgr357	179	6	revealed	reveal	VBD
cord-017585-0llgr357	179	7	distinct	distinct	JJ
cord-017585-0llgr357	179	8	patterns	pattern	NNS
cord-017585-0llgr357	179	9	of	of	IN
cord-017585-0llgr357	179	10	staining	stain	VBG
cord-017585-0llgr357	179	11	for	for	IN
cord-017585-0llgr357	179	12	ACE2	ACE2	NNP
cord-017585-0llgr357	179	13	and	and	CC
cord-017585-0llgr357	179	14	ACE	ACE	NNP
cord-017585-0llgr357	179	15	within	within	IN
cord-017585-0llgr357	179	16	the	the	DT
cord-017585-0llgr357	179	17	glomerulus	glomerulus	NN
cord-017585-0llgr357	179	18	-ACE2	-ACE2	NNP
cord-017585-0llgr357	179	19	in	in	IN
cord-017585-0llgr357	179	20	podocytes	podocyte	NNS
cord-017585-0llgr357	179	21	and	and	CC
cord-017585-0llgr357	179	22	ACE	ace	NN
cord-017585-0llgr357	179	23	in	in	IN
cord-017585-0llgr357	179	24	the	the	DT
cord-017585-0llgr357	179	25	endothelial	endothelial	JJ
cord-017585-0llgr357	179	26	cells	cell	NNS
cord-017585-0llgr357	179	27	(	(	-LRB-
cord-017585-0llgr357	179	28	Liebau	Liebau	NNP
cord-017585-0llgr357	179	29	et	et	NNP
cord-017585-0llgr357	179	30	al	al	NNP
cord-017585-0llgr357	179	31	2006	2006	CD
cord-017585-0llgr357	179	32	)	)	-RRB-
cord-017585-0llgr357	179	33	.	.	.
cord-017585-0llgr357	180	1	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	180	2	-	-	HYPH
cord-017585-0llgr357	180	3	7	7	CD
cord-017585-0llgr357	180	4	)	)	-RRB-
cord-017585-0llgr357	180	5	or	or	CC
cord-017585-0llgr357	180	6	the	the	DT
cord-017585-0llgr357	180	7	nonpeptide	nonpeptide	JJ
cord-017585-0llgr357	180	8	agonist	agonist	NN
cord-017585-0llgr357	180	9	AVE0991	AVE0991	NNP
cord-017585-0llgr357	180	10	attenuates	attenuate	VBZ
cord-017585-0llgr357	180	11	proteinuria	proteinuria	NN
cord-017585-0llgr357	180	12	and	and	CC
cord-017585-0llgr357	180	13	improves	improve	VBZ
cord-017585-0llgr357	180	14	renal	renal	JJ
cord-017585-0llgr357	180	15	vascular	vascular	JJ
cord-017585-0llgr357	180	16	activity	activity	NN
cord-017585-0llgr357	180	17	in	in	IN
cord-017585-0llgr357	180	18	the	the	DT
cord-017585-0llgr357	180	19	streptozoticin	streptozoticin	NNS
cord-017585-0llgr357	180	20	Type	Type	NNP
cord-017585-0llgr357	180	21	1	1	CD
cord-017585-0llgr357	180	22	diabetic	diabetic	JJ
cord-017585-0llgr357	180	23	rat	rat	NN
cord-017585-0llgr357	180	24	,	,	,
cord-017585-0llgr357	180	25	but	but	CC
cord-017585-0llgr357	180	26	did	do	VBD
cord-017585-0llgr357	180	27	not	not	RB
cord-017585-0llgr357	180	28	reverse	reverse	VB
cord-017585-0llgr357	180	29	the	the	DT
cord-017585-0llgr357	180	30	urinary	urinary	JJ
cord-017585-0llgr357	180	31	excretion	excretion	NN
cord-017585-0llgr357	180	32	of	of	IN
cord-017585-0llgr357	180	33	lysozyme	lysozyme	NNS
cord-017585-0llgr357	180	34	,	,	,
cord-017585-0llgr357	180	35	a	a	DT
cord-017585-0llgr357	180	36	marker	marker	NN
cord-017585-0llgr357	180	37	of	of	IN
cord-017585-0llgr357	180	38	tubulointerstitial	tubulointerstitial	JJ
cord-017585-0llgr357	180	39	damage	damage	NN
cord-017585-0llgr357	181	1	(	(	-LRB-
cord-017585-0llgr357	181	2	Benter	Benter	NNP
cord-017585-0llgr357	181	3	et	et	NNP
cord-017585-0llgr357	181	4	al	al	NNP
cord-017585-0llgr357	181	5	2007	2007	CD
cord-017585-0llgr357	181	6	)	)	-RRB-
cord-017585-0llgr357	181	7	.	.	.
cord-017585-0llgr357	182	1	Moreover	moreover	RB
cord-017585-0llgr357	182	2	,	,	,
cord-017585-0llgr357	182	3	the	the	DT
cord-017585-0llgr357	182	4	ratio	ratio	NN
cord-017585-0llgr357	182	5	of	of	IN
cord-017585-0llgr357	182	6	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	182	7	-	-	HYPH
cord-017585-0llgr357	182	8	7	7	CD
cord-017585-0llgr357	182	9	)	)	-RRB-
cord-017585-0llgr357	182	10	to	to	IN
cord-017585-0llgr357	182	11	Ang	Ang	NNP
cord-017585-0llgr357	182	12	II	II	NNP
cord-017585-0llgr357	182	13	formed	form	VBN
cord-017585-0llgr357	182	14	from	from	IN
cord-017585-0llgr357	182	15	exogenous	exogenous	JJ
cord-017585-0llgr357	182	16	Ang	Ang	NNP
cord-017585-0llgr357	183	1	I	-PRON-	PRP
cord-017585-0llgr357	183	2	was	be	VBD
cord-017585-0llgr357	183	3	lower	low	JJR
cord-017585-0llgr357	183	4	in	in	IN
cord-017585-0llgr357	183	5	glomeruli	glomerulus	NNS
cord-017585-0llgr357	183	6	isolated	isolate	VBN
cord-017585-0llgr357	183	7	from	from	IN
cord-017585-0llgr357	183	8	the	the	DT
cord-017585-0llgr357	183	9	kidneys	kidney	NNS
cord-017585-0llgr357	183	10	of	of	IN
cord-017585-0llgr357	183	11	diabetic	diabetic	JJ
cord-017585-0llgr357	183	12	rats	rat	NNS
cord-017585-0llgr357	183	13	,	,	,
cord-017585-0llgr357	183	14	however	however	RB
cord-017585-0llgr357	183	15	,	,	,
cord-017585-0llgr357	183	16	the	the	DT
cord-017585-0llgr357	183	17	identity	identity	NN
cord-017585-0llgr357	183	18	of	of	IN
cord-017585-0llgr357	183	19	the	the	DT
cord-017585-0llgr357	183	20	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	183	21	-	-	HYPH
cord-017585-0llgr357	183	22	7)-forming	7)-forming	CD
cord-017585-0llgr357	183	23	activity	activity	NN
cord-017585-0llgr357	183	24	was	be	VBD
cord-017585-0llgr357	183	25	not	not	RB
cord-017585-0llgr357	183	26	determined	determine	VBN
cord-017585-0llgr357	183	27	in	in	IN
cord-017585-0llgr357	183	28	this	this	DT
cord-017585-0llgr357	183	29	study	study	NN
cord-017585-0llgr357	183	30	(	(	-LRB-
cord-017585-0llgr357	183	31	Singh	Singh	NNP
cord-017585-0llgr357	183	32	et	et	NNP
cord-017585-0llgr357	183	33	al	al	NNP
cord-017585-0llgr357	183	34	2005	2005	CD
cord-017585-0llgr357	183	35	)	)	-RRB-
cord-017585-0llgr357	183	36	.	.	.
cord-017585-0llgr357	184	1	Thus	thus	RB
cord-017585-0llgr357	184	2	,	,	,
cord-017585-0llgr357	184	3	in	in	IN
cord-017585-0llgr357	184	4	addition	addition	NN
cord-017585-0llgr357	184	5	to	to	IN
cord-017585-0llgr357	184	6	the	the	DT
cord-017585-0llgr357	184	7	proximal	proximal	JJ
cord-017585-0llgr357	184	8	tubule	tubule	NN
cord-017585-0llgr357	184	9	epithelium	epithelium	NN
cord-017585-0llgr357	184	10	,	,	,
cord-017585-0llgr357	184	11	the	the	DT
cord-017585-0llgr357	184	12	glomerulus	glomerulus	NN
cord-017585-0llgr357	184	13	may	may	MD
cord-017585-0llgr357	184	14	be	be	VB
cord-017585-0llgr357	184	15	a	a	DT
cord-017585-0llgr357	184	16	second	second	JJ
cord-017585-0llgr357	184	17	key	key	JJ
cord-017585-0llgr357	184	18	site	site	NN
cord-017585-0llgr357	184	19	within	within	IN
cord-017585-0llgr357	184	20	the	the	DT
cord-017585-0llgr357	184	21	kidney	kidney	NN
cord-017585-0llgr357	184	22	where	where	WRB
cord-017585-0llgr357	184	23	ACE2	ACE2	NNP
cord-017585-0llgr357	184	24	may	may	MD
cord-017585-0llgr357	184	25	influence	influence	VB
cord-017585-0llgr357	184	26	the	the	DT
cord-017585-0llgr357	184	27	local	local	JJ
cord-017585-0llgr357	184	28	expression	expression	NN
cord-017585-0llgr357	184	29	of	of	IN
cord-017585-0llgr357	184	30	angiotensin	angiotensin	NN
cord-017585-0llgr357	184	31	peptides	peptide	NNS
cord-017585-0llgr357	184	32	and	and	CC
cord-017585-0llgr357	184	33	renal	renal	JJ
cord-017585-0llgr357	184	34	function	function	NN
cord-017585-0llgr357	184	35	.	.	.
cord-017585-0llgr357	185	1	In	in	IN
cord-017585-0llgr357	185	2	the	the	DT
cord-017585-0llgr357	185	3	kidney	kidney	NN
cord-017585-0llgr357	185	4	,	,	,
cord-017585-0llgr357	185	5	the	the	DT
cord-017585-0llgr357	185	6	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	185	7	neprilysin	neprilysin	NNP
cord-017585-0llgr357	185	8	constitutes	constitute	VBZ
cord-017585-0llgr357	185	9	significant	significant	JJ
cord-017585-0llgr357	185	10	peptidase	peptidase	NN
cord-017585-0llgr357	185	11	activity	activity	NN
cord-017585-0llgr357	185	12	,	,	,
cord-017585-0llgr357	185	13	particularly	particularly	RB
cord-017585-0llgr357	185	14	within	within	IN
cord-017585-0llgr357	185	15	the	the	DT
cord-017585-0llgr357	185	16	brush	brush	NN
cord-017585-0llgr357	185	17	border	border	NN
cord-017585-0llgr357	185	18	region	region	NN
cord-017585-0llgr357	185	19	of	of	IN
cord-017585-0llgr357	185	20	the	the	DT
cord-017585-0llgr357	185	21	proximal	proximal	JJ
cord-017585-0llgr357	185	22	tubules	tubule	NNS
cord-017585-0llgr357	185	23	.	.	.
cord-017585-0llgr357	186	1	Similar	similar	JJ
cord-017585-0llgr357	186	2	to	to	IN
cord-017585-0llgr357	186	3	ACE	ACE	NNP
cord-017585-0llgr357	186	4	and	and	CC
cord-017585-0llgr357	186	5	ACE2	ACE2	NNP
cord-017585-0llgr357	186	6	,	,	,
cord-017585-0llgr357	186	7	neprilysin	neprilysin	NNP
cord-017585-0llgr357	186	8	is	be	VBZ
cord-017585-0llgr357	186	9	a	a	DT
cord-017585-0llgr357	186	10	zinc	zinc	NN
cord-017585-0llgr357	186	11	-	-	HYPH
cord-017585-0llgr357	186	12	dependent	dependent	JJ
cord-017585-0llgr357	186	13	metallopeptidase	metallopeptidase	NN
cord-017585-0llgr357	186	14	that	that	WDT
cord-017585-0llgr357	186	15	is	be	VBZ
cord-017585-0llgr357	186	16	anchored	anchor	VBN
cord-017585-0llgr357	186	17	to	to	IN
cord-017585-0llgr357	186	18	the	the	DT
cord-017585-0llgr357	186	19	apical	apical	JJ
cord-017585-0llgr357	186	20	or	or	CC
cord-017585-0llgr357	186	21	extracellular	extracellular	JJ
cord-017585-0llgr357	186	22	region	region	NN
cord-017585-0llgr357	186	23	of	of	IN
cord-017585-0llgr357	186	24	the	the	DT
cord-017585-0llgr357	186	25	membrane	membrane	NN
cord-017585-0llgr357	186	26	,	,	,
cord-017585-0llgr357	186	27	but	but	CC
cord-017585-0llgr357	186	28	is	be	VBZ
cord-017585-0llgr357	186	29	apparently	apparently	RB
cord-017585-0llgr357	186	30	resistant	resistant	JJ
cord-017585-0llgr357	186	31	to	to	IN
cord-017585-0llgr357	186	32	enzymatic	enzymatic	JJ
cord-017585-0llgr357	186	33	shedding	shedding	NN
cord-017585-0llgr357	186	34	.	.	.
cord-017585-0llgr357	187	1	Although	although	IN
cord-017585-0llgr357	187	2	neprilysin	neprilysin	NNP
cord-017585-0llgr357	187	3	was	be	VBD
cord-017585-0llgr357	187	4	initially	initially	RB
cord-017585-0llgr357	187	5	recognized	recognize	VBN
cord-017585-0llgr357	187	6	for	for	IN
cord-017585-0llgr357	187	7	its	-PRON-	PRP$
cord-017585-0llgr357	187	8	enkephalindegrading	enkephalindegrading	NN
cord-017585-0llgr357	187	9	activity	activity	NN
cord-017585-0llgr357	187	10	and	and	CC
cord-017585-0llgr357	187	11	frequently	frequently	RB
cord-017585-0llgr357	187	12	referred	refer	VBD
cord-017585-0llgr357	187	13	to	to	IN
cord-017585-0llgr357	187	14	as	as	IN
cord-017585-0llgr357	187	15	"	"	``
cord-017585-0llgr357	187	16	enkephalinase	enkephalinase	NNP
cord-017585-0llgr357	187	17	"	"	''
cord-017585-0llgr357	187	18	,	,	,
cord-017585-0llgr357	187	19	studies	study	NNS
cord-017585-0llgr357	187	20	now	now	RB
cord-017585-0llgr357	187	21	reveal	reveal	VBP
cord-017585-0llgr357	187	22	that	that	IN
cord-017585-0llgr357	187	23	this	this	DT
cord-017585-0llgr357	187	24	enzyme	enzyme	NN
cord-017585-0llgr357	187	25	contributes	contribute	VBZ
cord-017585-0llgr357	187	26	to	to	IN
cord-017585-0llgr357	187	27	the	the	DT
cord-017585-0llgr357	187	28	metabolism	metabolism	NN
cord-017585-0llgr357	187	29	of	of	IN
cord-017585-0llgr357	187	30	various	various	JJ
cord-017585-0llgr357	187	31	peptides	peptide	NNS
cord-017585-0llgr357	187	32	with	with	IN
cord-017585-0llgr357	187	33	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	187	34	actions	action	NNS
cord-017585-0llgr357	187	35	including	include	VBG
cord-017585-0llgr357	187	36	adrenomedullin	adrenomedullin	NNP
cord-017585-0llgr357	187	37	,	,	,
cord-017585-0llgr357	187	38	angiotensins	angiotensin	NNS
cord-017585-0llgr357	187	39	,	,	,
cord-017585-0llgr357	187	40	kinins	kinins	NNP
cord-017585-0llgr357	187	41	,	,	,
cord-017585-0llgr357	187	42	endothelins	endothelin	NNS
cord-017585-0llgr357	187	43	,	,	,
cord-017585-0llgr357	187	44	substance	substance	NN
cord-017585-0llgr357	187	45	P	p	NN
cord-017585-0llgr357	187	46	and	and	CC
cord-017585-0llgr357	187	47	the	the	DT
cord-017585-0llgr357	187	48	natriuretic	natriuretic	JJ
cord-017585-0llgr357	187	49	peptides	peptide	NNS
cord-017585-0llgr357	187	50	(	(	-LRB-
cord-017585-0llgr357	187	51	Skidgel	Skidgel	NNP
cord-017585-0llgr357	187	52	&	&	CC
cord-017585-0llgr357	187	53	Erdos	Erdos	NNP
cord-017585-0llgr357	187	54	2004	2004	CD
cord-017585-0llgr357	187	55	)	)	-RRB-
cord-017585-0llgr357	187	56	.	.	.
cord-017585-0llgr357	188	1	Indeed	indeed	RB
cord-017585-0llgr357	188	2	,	,	,
cord-017585-0llgr357	188	3	the	the	DT
cord-017585-0llgr357	188	4	development	development	NN
cord-017585-0llgr357	188	5	of	of	IN
cord-017585-0llgr357	188	6	neprilysin	neprilysin	NNP
cord-017585-0llgr357	188	7	inhibitors	inhibitor	NNS
cord-017585-0llgr357	188	8	,	,	,
cord-017585-0llgr357	188	9	and	and	CC
cord-017585-0llgr357	188	10	more	more	RBR
cord-017585-0llgr357	188	11	recently	recently	RB
cord-017585-0llgr357	188	12	,	,	,
cord-017585-0llgr357	188	13	dual	dual	JJ
cord-017585-0llgr357	188	14	or	or	CC
cord-017585-0llgr357	188	15	mixed	mixed	JJ
cord-017585-0llgr357	188	16	inhibitors	inhibitor	NNS
cord-017585-0llgr357	188	17	that	that	WDT
cord-017585-0llgr357	188	18	target	target	VBP
cord-017585-0llgr357	188	19	ACE	ACE	NNP
cord-017585-0llgr357	188	20	as	as	RB
cord-017585-0llgr357	188	21	well	well	RB
cord-017585-0llgr357	188	22	remain	remain	VBP
cord-017585-0llgr357	188	23	potential	potential	JJ
cord-017585-0llgr357	188	24	therapies	therapy	NNS
cord-017585-0llgr357	188	25	in	in	IN
cord-017585-0llgr357	188	26	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	188	27	disease	disease	NN
cord-017585-0llgr357	188	28	(	(	-LRB-
cord-017585-0llgr357	188	29	Veelken	Veelken	NNP
cord-017585-0llgr357	188	30	&	&	CC
cord-017585-0llgr357	188	31	Schmieder	Schmieder	NNP
cord-017585-0llgr357	188	32	2002	2002	CD
cord-017585-0llgr357	188	33	)	)	-RRB-
cord-017585-0llgr357	188	34	.	.	.
cord-017585-0llgr357	189	1	In	in	IN
cord-017585-0llgr357	189	2	general	general	JJ
cord-017585-0llgr357	189	3	,	,	,
cord-017585-0llgr357	189	4	these	these	DT
cord-017585-0llgr357	189	5	dual	dual	JJ
cord-017585-0llgr357	189	6	inhibitors	inhibitor	NNS
cord-017585-0llgr357	189	7	were	be	VBD
cord-017585-0llgr357	189	8	either	either	CC
cord-017585-0llgr357	189	9	equally	equally	RB
cord-017585-0llgr357	189	10	or	or	CC
cord-017585-0llgr357	189	11	more	more	RBR
cord-017585-0llgr357	189	12	effective	effective	JJ
cord-017585-0llgr357	189	13	in	in	IN
cord-017585-0llgr357	189	14	lowering	lower	VBG
cord-017585-0llgr357	189	15	blood	blood	NN
cord-017585-0llgr357	189	16	pressure	pressure	NN
cord-017585-0llgr357	189	17	and	and	CC
cord-017585-0llgr357	189	18	reducing	reduce	VBG
cord-017585-0llgr357	189	19	renal	renal	JJ
cord-017585-0llgr357	189	20	injury	injury	NN
cord-017585-0llgr357	189	21	as	as	IN
cord-017585-0llgr357	189	22	compared	compare	VBN
cord-017585-0llgr357	189	23	to	to	IN
cord-017585-0llgr357	189	24	monotherapy	monotherapy	NN
cord-017585-0llgr357	189	25	with	with	IN
cord-017585-0llgr357	189	26	an	an	DT
cord-017585-0llgr357	189	27	ACE	ACE	NNP
cord-017585-0llgr357	189	28	or	or	CC
cord-017585-0llgr357	189	29	neprilysin	neprilysin	JJ
cord-017585-0llgr357	189	30	inhibitor	inhibitor	NN
cord-017585-0llgr357	189	31	(	(	-LRB-
cord-017585-0llgr357	189	32	Kubota	Kubota	NNP
cord-017585-0llgr357	189	33	et	et	NNP
cord-017585-0llgr357	189	34	al	al	NNP
cord-017585-0llgr357	189	35	2003	2003	CD
cord-017585-0llgr357	189	36	;	;	:
cord-017585-0llgr357	189	37	Tikkanen	Tikkanen	NNP
cord-017585-0llgr357	189	38	et	et	NNP
cord-017585-0llgr357	189	39	al	al	NNP
cord-017585-0llgr357	189	40	2002	2002	CD
cord-017585-0llgr357	189	41	)	)	-RRB-
cord-017585-0llgr357	189	42	.	.	.
cord-017585-0llgr357	190	1	However	however	RB
cord-017585-0llgr357	190	2	,	,	,
cord-017585-0llgr357	190	3	two	two	CD
cord-017585-0llgr357	190	4	large	large	JJ
cord-017585-0llgr357	190	5	clinical	clinical	JJ
cord-017585-0llgr357	190	6	trials	trial	NNS
cord-017585-0llgr357	190	7	(	(	-LRB-
cord-017585-0llgr357	190	8	OCTAVE	octave	NN
cord-017585-0llgr357	190	9	,	,	,
cord-017585-0llgr357	190	10	OVERTURE	overture	NN
cord-017585-0llgr357	190	11	)	)	-RRB-
cord-017585-0llgr357	190	12	with	with	IN
cord-017585-0llgr357	190	13	the	the	DT
cord-017585-0llgr357	190	14	mixed	mixed	JJ
cord-017585-0llgr357	190	15	inhibitor	inhibitor	NN
cord-017585-0llgr357	190	16	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	190	17	revealed	reveal	VBD
cord-017585-0llgr357	190	18	an	an	DT
cord-017585-0llgr357	190	19	increased	increase	VBN
cord-017585-0llgr357	190	20	incidence	incidence	NN
cord-017585-0llgr357	190	21	of	of	IN
cord-017585-0llgr357	190	22	angioedema	angioedema	NN
cord-017585-0llgr357	190	23	.	.	.
cord-017585-0llgr357	191	1	Moreover	moreover	RB
cord-017585-0llgr357	191	2	,	,	,
cord-017585-0llgr357	191	3	the	the	DT
cord-017585-0llgr357	191	4	drug	drug	NN
cord-017585-0llgr357	191	5	was	be	VBD
cord-017585-0llgr357	191	6	no	no	DT
cord-017585-0llgr357	191	7	more	more	RBR
cord-017585-0llgr357	191	8	effective	effective	JJ
cord-017585-0llgr357	191	9	than	than	IN
cord-017585-0llgr357	191	10	an	an	DT
cord-017585-0llgr357	191	11	ACE	ace	NN
cord-017585-0llgr357	191	12	inhibitor	inhibitor	NN
cord-017585-0llgr357	191	13	alone	alone	RB
cord-017585-0llgr357	191	14	(	(	-LRB-
cord-017585-0llgr357	191	15	Kostis	Kostis	NNP
cord-017585-0llgr357	191	16	et	et	NNP
cord-017585-0llgr357	191	17	al	al	NNP
cord-017585-0llgr357	191	18	2004	2004	CD
cord-017585-0llgr357	191	19	;	;	:
cord-017585-0llgr357	191	20	Packer	Packer	NNP
cord-017585-0llgr357	191	21	et	et	NNP
cord-017585-0llgr357	191	22	al	al	NNP
cord-017585-0llgr357	191	23	2002	2002	CD
cord-017585-0llgr357	191	24	)	)	-RRB-
cord-017585-0llgr357	191	25	.	.	.
cord-017585-0llgr357	192	1	A	a	DT
cord-017585-0llgr357	192	2	subsequent	subsequent	JJ
cord-017585-0llgr357	192	3	experimental	experimental	JJ
cord-017585-0llgr357	192	4	study	study	NN
cord-017585-0llgr357	192	5	has	have	VBZ
cord-017585-0llgr357	192	6	shown	show	VBN
cord-017585-0llgr357	192	7	that	that	IN
cord-017585-0llgr357	192	8	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	192	9	inhibits	inhibit	VBZ
cord-017585-0llgr357	192	10	amniopeptidase	amniopeptidase	DT
cord-017585-0llgr357	192	11	P	p	NN
cord-017585-0llgr357	192	12	and	and	CC
cord-017585-0llgr357	192	13	,	,	,
cord-017585-0llgr357	192	14	although	although	IN
cord-017585-0llgr357	192	15	less	less	RBR
cord-017585-0llgr357	192	16	potent	potent	JJ
cord-017585-0llgr357	192	17	than	than	IN
cord-017585-0llgr357	192	18	its	-PRON-	PRP$
cord-017585-0llgr357	192	19	actions	action	NNS
cord-017585-0llgr357	192	20	against	against	IN
cord-017585-0llgr357	192	21	ACE	ACE	NNP
cord-017585-0llgr357	192	22	and	and	CC
cord-017585-0llgr357	192	23	neprilysin	neprilysin	NNP
cord-017585-0llgr357	192	24	,	,	,
cord-017585-0llgr357	192	25	this	this	DT
cord-017585-0llgr357	192	26	may	may	MD
cord-017585-0llgr357	192	27	further	further	RB
cord-017585-0llgr357	192	28	augment	augment	VB
cord-017585-0llgr357	192	29	the	the	DT
cord-017585-0llgr357	192	30	local	local	JJ
cord-017585-0llgr357	192	31	concentrations	concentration	NNS
cord-017585-0llgr357	192	32	of	of	IN
cord-017585-0llgr357	192	33	kinins	kinin	NNS
cord-017585-0llgr357	192	34	or	or	CC
cord-017585-0llgr357	192	35	substance	substance	NN
cord-017585-0llgr357	192	36	P	p	NN
cord-017585-0llgr357	192	37	to	to	TO
cord-017585-0llgr357	192	38	exacerbate	exacerbate	VB
cord-017585-0llgr357	192	39	vascular	vascular	JJ
cord-017585-0llgr357	192	40	permeability	permeability	NN
cord-017585-0llgr357	193	1	(	(	-LRB-
cord-017585-0llgr357	193	2	Sulpizio	Sulpizio	NNP
cord-017585-0llgr357	193	3	et	et	NNP
cord-017585-0llgr357	193	4	al	al	NNP
cord-017585-0llgr357	193	5	2005	2005	CD
cord-017585-0llgr357	193	6	)	)	-RRB-
cord-017585-0llgr357	193	7	.	.	.
cord-017585-0llgr357	194	1	In	in	IN
cord-017585-0llgr357	194	2	this	this	DT
cord-017585-0llgr357	194	3	aspect	aspect	NN
cord-017585-0llgr357	194	4	,	,	,
cord-017585-0llgr357	194	5	the	the	DT
cord-017585-0llgr357	194	6	development	development	NN
cord-017585-0llgr357	194	7	of	of	IN
cord-017585-0llgr357	194	8	more	more	RBR
cord-017585-0llgr357	194	9	selective	selective	JJ
cord-017585-0llgr357	194	10	inhibitors	inhibitor	NNS
cord-017585-0llgr357	194	11	against	against	IN
cord-017585-0llgr357	194	12	ACE	ACE	NNP
cord-017585-0llgr357	194	13	and	and	CC
cord-017585-0llgr357	194	14	neprilysin	neprilysin	NNP
cord-017585-0llgr357	194	15	may	may	MD
cord-017585-0llgr357	194	16	be	be	VB
cord-017585-0llgr357	194	17	of	of	IN
cord-017585-0llgr357	194	18	clinical	clinical	JJ
cord-017585-0llgr357	194	19	benefit	benefit	NN
cord-017585-0llgr357	194	20	.	.	.
cord-017585-0llgr357	195	1	The	the	DT
cord-017585-0llgr357	195	2	rationale	rationale	NN
cord-017585-0llgr357	195	3	for	for	IN
cord-017585-0llgr357	195	4	neprilysin	neprilysin	NNP
cord-017585-0llgr357	195	5	inhibition	inhibition	NN
cord-017585-0llgr357	195	6	primarily	primarily	RB
cord-017585-0llgr357	195	7	resides	reside	VBZ
cord-017585-0llgr357	195	8	in	in	IN
cord-017585-0llgr357	195	9	preserving	preserve	VBG
cord-017585-0llgr357	195	10	the	the	DT
cord-017585-0llgr357	195	11	"	"	``
cord-017585-0llgr357	195	12	cardioprotective	cardioprotective	JJ
cord-017585-0llgr357	195	13	"	"	''
cord-017585-0llgr357	195	14	peptides	peptide	NNS
cord-017585-0llgr357	195	15	bradykinin	bradykinin	NN
cord-017585-0llgr357	195	16	and	and	CC
cord-017585-0llgr357	195	17	ANP	ANP	NNP
cord-017585-0llgr357	195	18	or	or	CC
cord-017585-0llgr357	195	19	BNP	BNP	NNP
cord-017585-0llgr357	195	20	.	.	.
cord-017585-0llgr357	196	1	However	however	RB
cord-017585-0llgr357	196	2	,	,	,
cord-017585-0llgr357	196	3	neprilysin	neprilysin	NNP
cord-017585-0llgr357	196	4	readily	readily	RB
cord-017585-0llgr357	196	5	metabolizes	metabolize	VBZ
cord-017585-0llgr357	196	6	Ang	Ang	NNP
cord-017585-0llgr357	196	7	II	II	NNP
cord-017585-0llgr357	196	8	to	to	IN
cord-017585-0llgr357	196	9	the	the	DT
cord-017585-0llgr357	196	10	inactive	inactive	JJ
cord-017585-0llgr357	196	11	fragment	fragment	NN
cord-017585-0llgr357	196	12	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	196	13	-	-	HYPH
cord-017585-0llgr357	196	14	4	4	CD
cord-017585-0llgr357	196	15	)	)	-RRB-
cord-017585-0llgr357	196	16	which	which	WDT
cord-017585-0llgr357	196	17	undergoes	undergo	VBZ
cord-017585-0llgr357	196	18	further	further	JJ
cord-017585-0llgr357	196	19	hydrolysis	hydrolysis	NN
cord-017585-0llgr357	196	20	to	to	IN
cord-017585-0llgr357	196	21	the	the	DT
cord-017585-0llgr357	196	22	dipeptides	dipeptide	NNS
cord-017585-0llgr357	196	23	Asp	Asp	NNP
cord-017585-0llgr357	196	24	-	-	HYPH
cord-017585-0llgr357	196	25	Arg	Arg	NNP
cord-017585-0llgr357	196	26	and	and	CC
cord-017585-0llgr357	196	27	Val	Val	NNP
cord-017585-0llgr357	196	28	-	-	HYPH
cord-017585-0llgr357	196	29	Tyr	Tyr	NNP
cord-017585-0llgr357	196	30	.	.	.
cord-017585-0llgr357	197	1	Neprilysin	Neprilysin	NNP
cord-017585-0llgr357	197	2	also	also	RB
cord-017585-0llgr357	197	3	cleaves	cleave	VBZ
cord-017585-0llgr357	197	4	endothelin	endothelin	NNP
cord-017585-0llgr357	197	5	,	,	,
cord-017585-0llgr357	197	6	although	although	IN
cord-017585-0llgr357	197	7	it	-PRON-	PRP
cord-017585-0llgr357	197	8	is	be	VBZ
cord-017585-0llgr357	197	9	not	not	RB
cord-017585-0llgr357	197	10	clear	clear	JJ
cord-017585-0llgr357	197	11	to	to	TO
cord-017585-0llgr357	197	12	what	what	WDT
cord-017585-0llgr357	197	13	extent	extent	NN
cord-017585-0llgr357	197	14	reduced	reduce	VBN
cord-017585-0llgr357	197	15	intrarenal	intrarenal	JJ
cord-017585-0llgr357	197	16	levels	level	NNS
cord-017585-0llgr357	197	17	of	of	IN
cord-017585-0llgr357	197	18	endothelin	endothelin	NNP
cord-017585-0llgr357	197	19	are	be	VBP
cord-017585-0llgr357	197	20	beneficial	beneficial	JJ
cord-017585-0llgr357	197	21	given	give	VBN
cord-017585-0llgr357	197	22	the	the	DT
cord-017585-0llgr357	197	23	functional	functional	JJ
cord-017585-0llgr357	197	24	diversity	diversity	NN
cord-017585-0llgr357	197	25	of	of	IN
cord-017585-0llgr357	197	26	the	the	DT
cord-017585-0llgr357	197	27	endothelin	endothelin	NNP
cord-017585-0llgr357	197	28	A	A	NNP
cord-017585-0llgr357	197	29	and	and	CC
cord-017585-0llgr357	197	30	B	b	NN
cord-017585-0llgr357	197	31	receptor	receptor	NN
cord-017585-0llgr357	197	32	subtypes	subtype	NNS
cord-017585-0llgr357	197	33	within	within	IN
cord-017585-0llgr357	197	34	the	the	DT
cord-017585-0llgr357	197	35	kidney	kidney	NN
cord-017585-0llgr357	197	36	(	(	-LRB-
cord-017585-0llgr357	197	37	Schiffrin	Schiffrin	NNP
cord-017585-0llgr357	197	38	1999	1999	CD
cord-017585-0llgr357	197	39	)	)	-RRB-
cord-017585-0llgr357	197	40	.	.	.
cord-017585-0llgr357	198	1	The	the	DT
cord-017585-0llgr357	198	2	additional	additional	JJ
cord-017585-0llgr357	198	3	ACE	ace	NN
cord-017585-0llgr357	198	4	inhibition	inhibition	NN
cord-017585-0llgr357	198	5	would	would	MD
cord-017585-0llgr357	198	6	prevent	prevent	VB
cord-017585-0llgr357	198	7	the	the	DT
cord-017585-0llgr357	198	8	accumulation	accumulation	NN
cord-017585-0llgr357	198	9	of	of	IN
cord-017585-0llgr357	198	10	Ang	Ang	NNP
cord-017585-0llgr357	198	11	II	II	NNP
cord-017585-0llgr357	198	12	and	and	CC
cord-017585-0llgr357	198	13	further	further	RB
cord-017585-0llgr357	198	14	contribute	contribute	VB
cord-017585-0llgr357	198	15	to	to	IN
cord-017585-0llgr357	198	16	the	the	DT
cord-017585-0llgr357	198	17	protection	protection	NN
cord-017585-0llgr357	198	18	of	of	IN
cord-017585-0llgr357	198	19	kinins	kinins	NNP
cord-017585-0llgr357	198	20	,	,	,
cord-017585-0llgr357	198	21	as	as	RB
cord-017585-0llgr357	198	22	well	well	RB
cord-017585-0llgr357	198	23	as	as	IN
cord-017585-0llgr357	198	24	possibly	possibly	RB
cord-017585-0llgr357	198	25	reduce	reduce	VB
cord-017585-0llgr357	198	26	endothelin	endothelin	NN
cord-017585-0llgr357	198	27	release	release	NN
cord-017585-0llgr357	198	28	.	.	.
cord-017585-0llgr357	199	1	One	one	CD
cord-017585-0llgr357	199	2	possible	possible	JJ
cord-017585-0llgr357	199	3	caveat	caveat	NN
cord-017585-0llgr357	199	4	to	to	IN
cord-017585-0llgr357	199	5	this	this	DT
cord-017585-0llgr357	199	6	approach	approach	NN
cord-017585-0llgr357	199	7	is	be	VBZ
cord-017585-0llgr357	199	8	that	that	IN
cord-017585-0llgr357	199	9	neprilysin	neprilysin	NNP
cord-017585-0llgr357	199	10	is	be	VBZ
cord-017585-0llgr357	199	11	the	the	DT
cord-017585-0llgr357	199	12	major	major	JJ
cord-017585-0llgr357	199	13	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	199	14	-	-	HYPH
cord-017585-0llgr357	199	15	7)-forming	7)-forming	CD
cord-017585-0llgr357	199	16	activity	activity	NN
cord-017585-0llgr357	199	17	from	from	IN
cord-017585-0llgr357	199	18	Ang	Ang	NNP
cord-017585-0llgr357	199	19	I	I	NNP
cord-017585-0llgr357	199	20	or	or	CC
cord-017585-0llgr357	199	21	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	199	22	-	-	HYPH
cord-017585-0llgr357	199	23	9	9	CD
cord-017585-0llgr357	199	24	)	)	-RRB-
cord-017585-0llgr357	199	25	in	in	IN
cord-017585-0llgr357	199	26	the	the	DT
cord-017585-0llgr357	199	27	circulation	circulation	NN
cord-017585-0llgr357	200	1	(	(	-LRB-
cord-017585-0llgr357	200	2	Campbell	Campbell	NNP
cord-017585-0llgr357	200	3	et	et	NNP
cord-017585-0llgr357	200	4	al	al	NNP
cord-017585-0llgr357	200	5	1998	1998	CD
cord-017585-0llgr357	200	6	;	;	:
cord-017585-0llgr357	200	7	Yamamoto	Yamamoto	NNP
cord-017585-0llgr357	200	8	et	et	NNP
cord-017585-0llgr357	200	9	al	al	NNP
cord-017585-0llgr357	200	10	1992	1992	CD
cord-017585-0llgr357	200	11	)	)	-RRB-
cord-017585-0llgr357	200	12	.	.	.
cord-017585-0llgr357	201	1	Indeed	indeed	RB
cord-017585-0llgr357	201	2	,	,	,
cord-017585-0llgr357	201	3	acute	acute	JJ
cord-017585-0llgr357	201	4	administration	administration	NN
cord-017585-0llgr357	201	5	of	of	IN
cord-017585-0llgr357	201	6	the	the	DT
cord-017585-0llgr357	201	7	potent	potent	JJ
cord-017585-0llgr357	201	8	neprilysin	neprilysin	NNP
cord-017585-0llgr357	201	9	inhibitor	inhibitor	NN
cord-017585-0llgr357	201	10	SCH3977	SCH3977	NNP
cord-017585-0llgr357	201	11	reduced	reduce	VBN
cord-017585-0llgr357	201	12	circulating	circulate	VBG
cord-017585-0llgr357	201	13	levels	level	NNS
cord-017585-0llgr357	201	14	of	of	IN
cord-017585-0llgr357	201	15	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	201	16	-	-	HYPH
cord-017585-0llgr357	201	17	7	7	CD
cord-017585-0llgr357	201	18	)	)	-RRB-
cord-017585-0llgr357	201	19	and	and	CC
cord-017585-0llgr357	201	20	increased	increase	VBN
cord-017585-0llgr357	201	21	blood	blood	NN
cord-017585-0llgr357	201	22	pressure	pressure	NN
cord-017585-0llgr357	201	23	in	in	IN
cord-017585-0llgr357	201	24	the	the	DT
cord-017585-0llgr357	201	25	SHR	SHR	NNP
cord-017585-0llgr357	201	26	chronically	chronically	RB
cord-017585-0llgr357	201	27	treated	treat	VBN
cord-017585-0llgr357	201	28	with	with	IN
cord-017585-0llgr357	201	29	the	the	DT
cord-017585-0llgr357	201	30	ACE	ACE	NNP
cord-017585-0llgr357	201	31	inhibitor	inhibitor	NN
cord-017585-0llgr357	201	32	lisinoropril	lisinoropril	NNP
cord-017585-0llgr357	201	33	(	(	-LRB-
cord-017585-0llgr357	201	34	Iyer	Iyer	NNP
cord-017585-0llgr357	201	35	et	et	NNP
cord-017585-0llgr357	201	36	al	al	NNP
cord-017585-0llgr357	201	37	1997	1997	CD
cord-017585-0llgr357	201	38	)	)	-RRB-
cord-017585-0llgr357	201	39	.	.	.
cord-017585-0llgr357	202	1	Although	although	IN
cord-017585-0llgr357	202	2	plasma	plasma	NN
cord-017585-0llgr357	202	3	levels	level	NNS
cord-017585-0llgr357	202	4	of	of	IN
cord-017585-0llgr357	202	5	neprilysin	neprilysin	NNP
cord-017585-0llgr357	202	6	are	be	VBP
cord-017585-0llgr357	202	7	low	low	JJ
cord-017585-0llgr357	202	8	to	to	IN
cord-017585-0llgr357	202	9	non	non	JJ
cord-017585-0llgr357	202	10	-	-	JJ
cord-017585-0llgr357	202	11	detectable	detectable	JJ
cord-017585-0llgr357	202	12	,	,	,
cord-017585-0llgr357	202	13	the	the	DT
cord-017585-0llgr357	202	14	enzyme	enzyme	NN
cord-017585-0llgr357	202	15	is	be	VBZ
cord-017585-0llgr357	202	16	appropriately	appropriately	RB
cord-017585-0llgr357	202	17	localized	localize	VBN
cord-017585-0llgr357	202	18	to	to	IN
cord-017585-0llgr357	202	19	the	the	DT
cord-017585-0llgr357	202	20	ectocellular	ectocellular	JJ
cord-017585-0llgr357	202	21	surface	surface	NN
cord-017585-0llgr357	202	22	of	of	IN
cord-017585-0llgr357	202	23	endothelial	endothelial	JJ
cord-017585-0llgr357	202	24	and	and	CC
cord-017585-0llgr357	202	25	smooth	smooth	JJ
cord-017585-0llgr357	202	26	muscle	muscle	NN
cord-017585-0llgr357	202	27	cells	cell	NNS
cord-017585-0llgr357	202	28	to	to	TO
cord-017585-0llgr357	202	29	contribute	contribute	VB
cord-017585-0llgr357	202	30	to	to	IN
cord-017585-0llgr357	202	31	the	the	DT
cord-017585-0llgr357	202	32	formation	formation	NN
cord-017585-0llgr357	202	33	of	of	IN
cord-017585-0llgr357	202	34	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	202	35	-	-	HYPH
cord-017585-0llgr357	202	36	7	7	CD
cord-017585-0llgr357	202	37	)	)	-RRB-
cord-017585-0llgr357	202	38	within	within	IN
cord-017585-0llgr357	202	39	the	the	DT
cord-017585-0llgr357	202	40	vasculature	vasculature	NN
cord-017585-0llgr357	203	1	(	(	-LRB-
cord-017585-0llgr357	203	2	Llorens	Llorens	NNP
cord-017585-0llgr357	203	3	-	-	HYPH
cord-017585-0llgr357	203	4	Cortes	Cortes	NNP
cord-017585-0llgr357	203	5	et	et	NNP
cord-017585-0llgr357	203	6	al	al	NNP
cord-017585-0llgr357	203	7	1992	1992	CD
cord-017585-0llgr357	203	8	)	)	-RRB-
cord-017585-0llgr357	203	9	.	.	.
cord-017585-0llgr357	204	1	In	in	IN
cord-017585-0llgr357	204	2	the	the	DT
cord-017585-0llgr357	204	3	kidney	kidney	NN
cord-017585-0llgr357	204	4	,	,	,
cord-017585-0llgr357	204	5	neprilysin	neprilysin	NNP
cord-017585-0llgr357	204	6	may	may	MD
cord-017585-0llgr357	204	7	contribute	contribute	VB
cord-017585-0llgr357	204	8	to	to	IN
cord-017585-0llgr357	204	9	both	both	CC
cord-017585-0llgr357	204	10	the	the	DT
cord-017585-0llgr357	204	11	formation	formation	NN
cord-017585-0llgr357	204	12	as	as	RB
cord-017585-0llgr357	204	13	well	well	RB
cord-017585-0llgr357	204	14	as	as	IN
cord-017585-0llgr357	204	15	the	the	DT
cord-017585-0llgr357	204	16	degradation	degradation	NN
cord-017585-0llgr357	204	17	of	of	IN
cord-017585-0llgr357	204	18	the	the	DT
cord-017585-0llgr357	204	19	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	204	20	-	-	HYPH
cord-017585-0llgr357	204	21	7	7	CD
cord-017585-0llgr357	204	22	)	)	-RRB-
cord-017585-0llgr357	205	1	(	(	-LRB-
cord-017585-0llgr357	205	2	Allred	Allred	NNP
cord-017585-0llgr357	205	3	et	et	NNP
cord-017585-0llgr357	205	4	al	al	NNP
cord-017585-0llgr357	205	5	2000	2000	CD
cord-017585-0llgr357	205	6	)	)	-RRB-
cord-017585-0llgr357	205	7	.	.	.
cord-017585-0llgr357	206	1	Neprilysin	Neprilysin	NNP
cord-017585-0llgr357	206	2	cleaves	cleave	VBZ
cord-017585-0llgr357	206	3	the	the	DT
cord-017585-0llgr357	206	4	Pro	Pro	NNP
cord-017585-0llgr357	206	5	7	7	CD
cord-017585-0llgr357	206	6	-Phe	-phe	SYM
cord-017585-0llgr357	206	7	8	8	CD
cord-017585-0llgr357	206	8	bond	bond	NN
cord-017585-0llgr357	206	9	of	of	IN
cord-017585-0llgr357	206	10	Ang	Ang	NNP
cord-017585-0llgr357	206	11	I	I	NNP
cord-017585-0llgr357	206	12	to	to	IN
cord-017585-0llgr357	206	13	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	206	14	-	-	HYPH
cord-017585-0llgr357	206	15	7	7	CD
cord-017585-0llgr357	206	16	)	)	-RRB-
cord-017585-0llgr357	206	17	,	,	,
cord-017585-0llgr357	206	18	but	but	CC
cord-017585-0llgr357	206	19	the	the	DT
cord-017585-0llgr357	206	20	very	very	RB
cord-017585-0llgr357	206	21	high	high	JJ
cord-017585-0llgr357	206	22	levels	level	NNS
cord-017585-0llgr357	206	23	of	of	IN
cord-017585-0llgr357	206	24	the	the	DT
cord-017585-0llgr357	206	25	enzyme	enzyme	NN
cord-017585-0llgr357	206	26	in	in	IN
cord-017585-0llgr357	206	27	the	the	DT
cord-017585-0llgr357	206	28	kidney	kidney	NN
cord-017585-0llgr357	206	29	may	may	MD
cord-017585-0llgr357	206	30	continue	continue	VB
cord-017585-0llgr357	206	31	to	to	TO
cord-017585-0llgr357	206	32	metabolize	metabolize	VB
cord-017585-0llgr357	206	33	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	206	34	-	-	HYPH
cord-017585-0llgr357	206	35	7	7	CD
cord-017585-0llgr357	206	36	)	)	-RRB-
cord-017585-0llgr357	206	37	at	at	IN
cord-017585-0llgr357	206	38	the	the	DT
cord-017585-0llgr357	206	39	Tyr	Tyr	NNP
cord-017585-0llgr357	206	40	5	5	CD
cord-017585-0llgr357	206	41	-Ile	-Ile	NNP
cord-017585-0llgr357	206	42	6	6	CD
cord-017585-0llgr357	206	43	bond	bond	NN
cord-017585-0llgr357	206	44	to	to	TO
cord-017585-0llgr357	206	45	form	form	VB
cord-017585-0llgr357	206	46	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	206	47	-	-	HYPH
cord-017585-0llgr357	206	48	4	4	CD
cord-017585-0llgr357	206	49	)	)	-RRB-
cord-017585-0llgr357	206	50	and	and	CC
cord-017585-0llgr357	206	51	Ang-(5	Ang-(5	NNP
cord-017585-0llgr357	206	52	-	-	HYPH
cord-017585-0llgr357	206	53	7	7	CD
cord-017585-0llgr357	206	54	)	)	-RRB-
cord-017585-0llgr357	207	1	(	(	-LRB-
cord-017585-0llgr357	207	2	Allred	Allred	NNP
cord-017585-0llgr357	207	3	et	et	NNP
cord-017585-0llgr357	207	4	al	al	NNP
cord-017585-0llgr357	207	5	2000	2000	CD
cord-017585-0llgr357	207	6	;	;	:
cord-017585-0llgr357	207	7	Chappell	Chappell	NNP
cord-017585-0llgr357	207	8	et	et	NNP
cord-017585-0llgr357	207	9	al	al	NNP
cord-017585-0llgr357	207	10	2001	2001	CD
cord-017585-0llgr357	207	11	)	)	-RRB-
cord-017585-0llgr357	207	12	.	.	.
cord-017585-0llgr357	208	1	Indeed	indeed	RB
cord-017585-0llgr357	208	2	,	,	,
cord-017585-0llgr357	208	3	the	the	DT
cord-017585-0llgr357	208	4	mixed	mixed	JJ
cord-017585-0llgr357	208	5	inhibitor	inhibitor	NN
cord-017585-0llgr357	208	6	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	208	7	augmented	augment	VBD
cord-017585-0llgr357	208	8	the	the	DT
cord-017585-0llgr357	208	9	urinary	urinary	JJ
cord-017585-0llgr357	208	10	levels	level	NNS
cord-017585-0llgr357	208	11	of	of	IN
cord-017585-0llgr357	208	12	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	208	13	-	-	HYPH
cord-017585-0llgr357	208	14	7	7	CD
cord-017585-0llgr357	208	15	)	)	-RRB-
cord-017585-0llgr357	208	16	in	in	IN
cord-017585-0llgr357	208	17	both	both	DT
cord-017585-0llgr357	208	18	human	human	JJ
cord-017585-0llgr357	208	19	hypertensives	hypertensive	NNS
cord-017585-0llgr357	208	20	and	and	CC
cord-017585-0llgr357	208	21	the	the	DT
cord-017585-0llgr357	208	22	SHR	SHR	NNP
cord-017585-0llgr357	208	23	model	model	NN
cord-017585-0llgr357	209	1	(	(	-LRB-
cord-017585-0llgr357	209	2	Ferrario	Ferrario	NNP
cord-017585-0llgr357	209	3	et	et	NNP
cord-017585-0llgr357	209	4	al	al	NNP
cord-017585-0llgr357	209	5	2002a	2002a	CD
cord-017585-0llgr357	209	6	;	;	:
cord-017585-0llgr357	209	7	Ferrario	Ferrario	NNP
cord-017585-0llgr357	209	8	et	et	NNP
cord-017585-0llgr357	209	9	al	al	NNP
cord-017585-0llgr357	209	10	2002b	2002b	CD
cord-017585-0llgr357	209	11	)	)	-RRB-
cord-017585-0llgr357	209	12	.	.	.
cord-017585-0llgr357	210	1	The	the	DT
cord-017585-0llgr357	210	2	clinical	clinical	JJ
cord-017585-0llgr357	210	3	study	study	NN
cord-017585-0llgr357	210	4	revealed	reveal	VBD
cord-017585-0llgr357	210	5	a	a	DT
cord-017585-0llgr357	210	6	strong	strong	JJ
cord-017585-0llgr357	210	7	correlation	correlation	NN
cord-017585-0llgr357	210	8	between	between	IN
cord-017585-0llgr357	210	9	the	the	DT
cord-017585-0llgr357	210	10	reduction	reduction	NN
cord-017585-0llgr357	210	11	in	in	IN
cord-017585-0llgr357	210	12	blood	blood	NN
cord-017585-0llgr357	210	13	pressure	pressure	NN
cord-017585-0llgr357	210	14	and	and	CC
cord-017585-0llgr357	210	15	increased	increase	VBN
cord-017585-0llgr357	210	16	excretion	excretion	NN
cord-017585-0llgr357	210	17	of	of	IN
cord-017585-0llgr357	210	18	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	210	19	-	-	HYPH
cord-017585-0llgr357	210	20	7	7	CD
cord-017585-0llgr357	210	21	)	)	-RRB-
cord-017585-0llgr357	210	22	with	with	IN
cord-017585-0llgr357	210	23	the	the	DT
cord-017585-0llgr357	210	24	dual	dual	JJ
cord-017585-0llgr357	210	25	peptidase	peptidase	NN
cord-017585-0llgr357	210	26	inhibitor	inhibitor	NN
cord-017585-0llgr357	210	27	(	(	-LRB-
cord-017585-0llgr357	210	28	Ferrario	Ferrario	NNP
cord-017585-0llgr357	210	29	et	et	FW
cord-017585-0llgr357	210	30	al	al	NNP
cord-017585-0llgr357	210	31	2002a	2002a	CD
cord-017585-0llgr357	210	32	)	)	-RRB-
cord-017585-0llgr357	210	33	.	.	.
cord-017585-0llgr357	211	1	Interestingly	interestingly	RB
cord-017585-0llgr357	211	2	,	,	,
cord-017585-0llgr357	211	3	chronic	chronic	JJ
cord-017585-0llgr357	211	4	treatment	treatment	NN
cord-017585-0llgr357	211	5	of	of	IN
cord-017585-0llgr357	211	6	male	male	JJ
cord-017585-0llgr357	211	7	SHR	SHR	NNP
cord-017585-0llgr357	211	8	with	with	IN
cord-017585-0llgr357	211	9	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	211	10	(	(	-LRB-
cord-017585-0llgr357	211	11	2	2	CD
cord-017585-0llgr357	211	12	weeks	week	NNS
cord-017585-0llgr357	211	13	,	,	,
cord-017585-0llgr357	211	14	30	30	CD
cord-017585-0llgr357	211	15	mg	mg	NN
cord-017585-0llgr357	211	16	/	/	SYM
cord-017585-0llgr357	211	17	kg	kg	NNP
cord-017585-0llgr357	211	18	daily	daily	NN
cord-017585-0llgr357	211	19	)	)	-RRB-
cord-017585-0llgr357	211	20	was	be	VBD
cord-017585-0llgr357	211	21	also	also	RB
cord-017585-0llgr357	211	22	associated	associate	VBN
cord-017585-0llgr357	211	23	with	with	IN
cord-017585-0llgr357	211	24	the	the	DT
cord-017585-0llgr357	211	25	increased	increase	VBN
cord-017585-0llgr357	211	26	renal	renal	JJ
cord-017585-0llgr357	211	27	expression	expression	NN
cord-017585-0llgr357	211	28	of	of	IN
cord-017585-0llgr357	211	29	ACE2	ACE2	NNP
cord-017585-0llgr357	211	30	.	.	.
cord-017585-0llgr357	212	1	As	as	IN
cord-017585-0llgr357	212	2	shown	show	VBN
cord-017585-0llgr357	212	3	in	in	IN
cord-017585-0llgr357	212	4	Fig	Fig	NNP
cord-017585-0llgr357	212	5	.	.	.
cord-017585-0llgr357	213	1	5	5	LS
cord-017585-0llgr357	213	2	,	,	,
cord-017585-0llgr357	213	3	immunocytochemical	immunocytochemical	NNP
cord-017585-0llgr357	213	4	studies	study	NNS
cord-017585-0llgr357	213	5	demonstrate	demonstrate	VBP
cord-017585-0llgr357	213	6	enhanced	enhanced	JJ
cord-017585-0llgr357	213	7	expression	expression	NN
cord-017585-0llgr357	213	8	Figure	figure	NN
cord-017585-0llgr357	213	9	5	5	CD
cord-017585-0llgr357	213	10	.	.	.
cord-017585-0llgr357	214	1	Increased	increase	VBN
cord-017585-0llgr357	214	2	expression	expression	NN
cord-017585-0llgr357	214	3	of	of	IN
cord-017585-0llgr357	214	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	214	5	-	-	HYPH
cord-017585-0llgr357	214	6	7	7	CD
cord-017585-0llgr357	214	7	)	)	-RRB-
cord-017585-0llgr357	214	8	and	and	CC
cord-017585-0llgr357	214	9	ACE2	ACE2	NNP
cord-017585-0llgr357	214	10	in	in	IN
cord-017585-0llgr357	214	11	the	the	DT
cord-017585-0llgr357	214	12	renal	renal	JJ
cord-017585-0llgr357	214	13	cortex	cortex	NN
cord-017585-0llgr357	214	14	of	of	IN
cord-017585-0llgr357	214	15	SHR	SHR	NNP
cord-017585-0llgr357	214	16	following	follow	VBG
cord-017585-0llgr357	214	17	treatment	treatment	NN
cord-017585-0llgr357	214	18	with	with	IN
cord-017585-0llgr357	214	19	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	214	20	.	.	.
cord-017585-0llgr357	215	1	Immunocytochemical	Immunocytochemical	NNP
cord-017585-0llgr357	215	2	staining	stain	VBG
cord-017585-0llgr357	215	3	for	for	IN
cord-017585-0llgr357	215	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	215	5	-	-	HYPH
cord-017585-0llgr357	215	6	7	7	CD
cord-017585-0llgr357	215	7	)	)	-RRB-
cord-017585-0llgr357	215	8	in	in	IN
cord-017585-0llgr357	215	9	control	control	NN
cord-017585-0llgr357	215	10	(	(	-LRB-
cord-017585-0llgr357	215	11	A	a	NN
cord-017585-0llgr357	215	12	)	)	-RRB-
cord-017585-0llgr357	215	13	and	and	CC
cord-017585-0llgr357	215	14	treated	treat	VBN
cord-017585-0llgr357	216	1	(	(	-LRB-
cord-017585-0llgr357	216	2	B	b	NN
cord-017585-0llgr357	216	3	)	)	-RRB-
cord-017585-0llgr357	216	4	SHR	SHR	NNP
cord-017585-0llgr357	216	5	;	;	:
cord-017585-0llgr357	217	1	ACE2	ace2	JJ
cord-017585-0llgr357	217	2	staining	staining	NN
cord-017585-0llgr357	217	3	in	in	IN
cord-017585-0llgr357	217	4	control	control	NN
cord-017585-0llgr357	217	5	(	(	-LRB-
cord-017585-0llgr357	217	6	C	C	NNP
cord-017585-0llgr357	217	7	)	)	-RRB-
cord-017585-0llgr357	217	8	and	and	CC
cord-017585-0llgr357	217	9	treated	treat	VBN
cord-017585-0llgr357	217	10	(	(	-LRB-
cord-017585-0llgr357	217	11	D	D	NNP
cord-017585-0llgr357	217	12	)	)	-RRB-
cord-017585-0llgr357	217	13	,	,	,
cord-017585-0llgr357	217	14	group	group	NN
cord-017585-0llgr357	217	15	.	.	.
cord-017585-0llgr357	218	1	ACE2	ace2	JJ
cord-017585-0llgr357	218	2	staining	staining	NN
cord-017585-0llgr357	218	3	in	in	IN
cord-017585-0llgr357	218	4	renal	renal	JJ
cord-017585-0llgr357	218	5	artery	artery	NN
cord-017585-0llgr357	218	6	of	of	IN
cord-017585-0llgr357	218	7	treated	treat	VBN
cord-017585-0llgr357	218	8	SHR	SHR	NNP
cord-017585-0llgr357	218	9	;	;	:
cord-017585-0llgr357	218	10	arrow	arrow	NNP
cord-017585-0llgr357	218	11	indicates	indicate	VBZ
cord-017585-0llgr357	218	12	intimal	intimal	JJ
cord-017585-0llgr357	218	13	layer	layer	NN
cord-017585-0llgr357	218	14	(	(	-LRB-
cord-017585-0llgr357	218	15	E	E	NNP
cord-017585-0llgr357	218	16	)	)	-RRB-
cord-017585-0llgr357	218	17	.	.	.
cord-017585-0llgr357	219	1	Renal	renal	JJ
cord-017585-0llgr357	219	2	cortical	cortical	JJ
cord-017585-0llgr357	219	3	ACE2	ACE2	NNP
cord-017585-0llgr357	219	4	mRNA	mrna	NN
cord-017585-0llgr357	219	5	levels	level	NNS
cord-017585-0llgr357	219	6	are	be	VBP
cord-017585-0llgr357	219	7	significantly	significantly	RB
cord-017585-0llgr357	219	8	increased	increase	VBN
cord-017585-0llgr357	219	9	2-fold	2-fold	JJ
cord-017585-0llgr357	219	10	following	follow	VBG
cord-017585-0llgr357	219	11	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	219	12	treatment	treatment	NN
cord-017585-0llgr357	219	13	(	(	-LRB-
cord-017585-0llgr357	219	14	F	F	NNP
cord-017585-0llgr357	219	15	)	)	-RRB-
cord-017585-0llgr357	219	16	;	;	:
cord-017585-0llgr357	219	17	inset	inset	NN
cord-017585-0llgr357	219	18	:	:	:
cord-017585-0llgr357	220	1	ACE2	ACE2	NNP
cord-017585-0llgr357	220	2	and	and	CC
cord-017585-0llgr357	220	3	EF-1	EF-1	NNP
cord-017585-0llgr357	220	4	bands	band	NNS
cord-017585-0llgr357	220	5	in	in	IN
cord-017585-0llgr357	220	6	the	the	DT
cord-017585-0llgr357	220	7	presence	presence	NN
cord-017585-0llgr357	220	8	of	of	IN
cord-017585-0llgr357	220	9	the	the	DT
cord-017585-0llgr357	220	10	specific	specific	JJ
cord-017585-0llgr357	220	11	RT	RT	NNP
cord-017585-0llgr357	220	12	primers	primer	NNS
cord-017585-0llgr357	220	13	(	(	-LRB-
cord-017585-0llgr357	220	14	RT+	RT+	NNP
cord-017585-0llgr357	220	15	)	)	-RRB-
cord-017585-0llgr357	220	16	.	.	.
cord-017585-0llgr357	221	1	Data	datum	NNS
cord-017585-0llgr357	221	2	are	be	VBP
cord-017585-0llgr357	221	3	n	n	NN
cord-017585-0llgr357	221	4	=	=	SYM
cord-017585-0llgr357	221	5	7	7	CD
cord-017585-0llgr357	221	6	-	-	SYM
cord-017585-0llgr357	221	7	8	8	CD
cord-017585-0llgr357	221	8	,	,	,
cord-017585-0llgr357	221	9	mean	mean	VB
cord-017585-0llgr357	222	1	±	±	NNP
cord-017585-0llgr357	222	2	SEM	SEM	NNP
cord-017585-0llgr357	222	3	of	of	IN
cord-017585-0llgr357	222	4	both	both	CC
cord-017585-0llgr357	222	5	ACE2	ACE2	NNP
cord-017585-0llgr357	222	6	and	and	CC
cord-017585-0llgr357	222	7	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	222	8	-	-	HYPH
cord-017585-0llgr357	222	9	7	7	CD
cord-017585-0llgr357	222	10	)	)	-RRB-
cord-017585-0llgr357	222	11	within	within	IN
cord-017585-0llgr357	222	12	the	the	DT
cord-017585-0llgr357	222	13	renal	renal	JJ
cord-017585-0llgr357	222	14	cortex	cortex	NN
cord-017585-0llgr357	222	15	of	of	IN
cord-017585-0llgr357	222	16	the	the	DT
cord-017585-0llgr357	222	17	treated	treat	VBN
cord-017585-0llgr357	222	18	-	-	HYPH
cord-017585-0llgr357	222	19	SHR	SHR	NNP
cord-017585-0llgr357	222	20	.	.	.
cord-017585-0llgr357	223	1	Omapatrilat	Omapatrilat	NNP
cord-017585-0llgr357	223	2	treatment	treatment	NN
cord-017585-0llgr357	223	3	also	also	RB
cord-017585-0llgr357	223	4	revealed	reveal	VBD
cord-017585-0llgr357	223	5	the	the	DT
cord-017585-0llgr357	223	6	renal	renal	JJ
cord-017585-0llgr357	223	7	vascular	vascular	JJ
cord-017585-0llgr357	223	8	expression	expression	NN
cord-017585-0llgr357	223	9	of	of	IN
cord-017585-0llgr357	223	10	ACE2	ACE2	NNP
cord-017585-0llgr357	223	11	with	with	IN
cord-017585-0llgr357	223	12	staining	stain	VBG
cord-017585-0llgr357	223	13	evident	evident	JJ
cord-017585-0llgr357	223	14	in	in	IN
cord-017585-0llgr357	223	15	the	the	DT
cord-017585-0llgr357	223	16	intimal	intimal	JJ
cord-017585-0llgr357	223	17	,	,	,
cord-017585-0llgr357	223	18	medial	medial	JJ
cord-017585-0llgr357	223	19	and	and	CC
cord-017585-0llgr357	223	20	adventitial	adventitial	JJ
cord-017585-0llgr357	223	21	regions	region	NNS
cord-017585-0llgr357	223	22	of	of	IN
cord-017585-0llgr357	223	23	the	the	DT
cord-017585-0llgr357	223	24	renal	renal	JJ
cord-017585-0llgr357	223	25	artery	artery	NN
cord-017585-0llgr357	223	26	(	(	-LRB-
cord-017585-0llgr357	223	27	Fig	Fig	NNP
cord-017585-0llgr357	223	28	.	.	.
cord-017585-0llgr357	223	29	5E	5E	NNP
cord-017585-0llgr357	223	30	)	)	-RRB-
cord-017585-0llgr357	223	31	;	;	,
cord-017585-0llgr357	223	32	vascular	vascular	JJ
cord-017585-0llgr357	223	33	staining	staining	NN
cord-017585-0llgr357	223	34	for	for	IN
cord-017585-0llgr357	223	35	the	the	DT
cord-017585-0llgr357	223	36	enzyme	enzyme	NN
cord-017585-0llgr357	223	37	was	be	VBD
cord-017585-0llgr357	223	38	undetectable	undetectable	JJ
cord-017585-0llgr357	223	39	in	in	IN
cord-017585-0llgr357	223	40	the	the	DT
cord-017585-0llgr357	223	41	untreated	untreated	JJ
cord-017585-0llgr357	223	42	SHR	SHR	NNP
cord-017585-0llgr357	223	43	group	group	NN
cord-017585-0llgr357	223	44	(	(	-LRB-
cord-017585-0llgr357	223	45	Fig	Fig	NNP
cord-017585-0llgr357	223	46	.	.	.
cord-017585-0llgr357	223	47	5C	5c	CD
cord-017585-0llgr357	223	48	)	)	-RRB-
cord-017585-0llgr357	223	49	.	.	.
cord-017585-0llgr357	224	1	Cortical	cortical	JJ
cord-017585-0llgr357	224	2	mRNA	mrna	NN
cord-017585-0llgr357	224	3	of	of	IN
cord-017585-0llgr357	224	4	ACE2	ACE2	NNP
cord-017585-0llgr357	224	5	expressed	express	VBD
cord-017585-0llgr357	224	6	as	as	IN
cord-017585-0llgr357	224	7	a	a	DT
cord-017585-0llgr357	224	8	ratio	ratio	NN
cord-017585-0llgr357	224	9	to	to	IN
cord-017585-0llgr357	224	10	EF-1	EF-1	NNP
cord-017585-0llgr357	224	11	increased	increase	VBD
cord-017585-0llgr357	224	12	2-fold	2-fold	CD
cord-017585-0llgr357	224	13	suggesting	suggest	VBG
cord-017585-0llgr357	224	14	that	that	IN
cord-017585-0llgr357	224	15	transcriptional	transcriptional	JJ
cord-017585-0llgr357	224	16	regulation	regulation	NN
cord-017585-0llgr357	224	17	contributes	contribute	VBZ
cord-017585-0llgr357	224	18	to	to	IN
cord-017585-0llgr357	224	19	the	the	DT
cord-017585-0llgr357	224	20	enhanced	enhanced	JJ
cord-017585-0llgr357	224	21	expression	expression	NN
cord-017585-0llgr357	224	22	of	of	IN
cord-017585-0llgr357	224	23	ACE2	ACE2	NNP
cord-017585-0llgr357	224	24	within	within	IN
cord-017585-0llgr357	224	25	the	the	DT
cord-017585-0llgr357	224	26	kidney	kidney	NN
cord-017585-0llgr357	224	27	(	(	-LRB-
cord-017585-0llgr357	224	28	Fig	Fig	NNP
cord-017585-0llgr357	224	29	.	.	.
cord-017585-0llgr357	224	30	5F	5F	NNP
cord-017585-0llgr357	224	31	)	)	-RRB-
cord-017585-0llgr357	224	32	.	.	.
cord-017585-0llgr357	225	1	These	these	DT
cord-017585-0llgr357	225	2	studies	study	NNS
cord-017585-0llgr357	225	3	are	be	VBP
cord-017585-0llgr357	225	4	of	of	IN
cord-017585-0llgr357	225	5	interest	interest	NN
cord-017585-0llgr357	225	6	as	as	IN
cord-017585-0llgr357	225	7	they	-PRON-	PRP
cord-017585-0llgr357	225	8	reveal	reveal	VBP
cord-017585-0llgr357	225	9	an	an	DT
cord-017585-0llgr357	225	10	additional	additional	JJ
cord-017585-0llgr357	225	11	mechanism	mechanism	NN
cord-017585-0llgr357	225	12	of	of	IN
cord-017585-0llgr357	225	13	the	the	DT
cord-017585-0llgr357	225	14	vasopeptidase	vasopeptidase	JJ
cord-017585-0llgr357	225	15	inhibitor	inhibitor	NN
cord-017585-0llgr357	225	16	that	that	WDT
cord-017585-0llgr357	225	17	may	may	MD
cord-017585-0llgr357	225	18	result	result	VB
cord-017585-0llgr357	225	19	in	in	IN
cord-017585-0llgr357	225	20	the	the	DT
cord-017585-0llgr357	225	21	enhanced	enhanced	JJ
cord-017585-0llgr357	225	22	conversion	conversion	NN
cord-017585-0llgr357	225	23	of	of	IN
cord-017585-0llgr357	225	24	Ang	Ang	NNP
cord-017585-0llgr357	225	25	II	II	NNP
cord-017585-0llgr357	225	26	to	to	IN
cord-017585-0llgr357	225	27	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	225	28	-	-	HYPH
cord-017585-0llgr357	225	29	7	7	CD
cord-017585-0llgr357	225	30	)	)	-RRB-
cord-017585-0llgr357	225	31	by	by	IN
cord-017585-0llgr357	225	32	ACE2	ACE2	NNP
cord-017585-0llgr357	225	33	,	,	,
cord-017585-0llgr357	225	34	as	as	RB
cord-017585-0llgr357	225	35	well	well	RB
cord-017585-0llgr357	225	36	as	as	IN
cord-017585-0llgr357	225	37	protecting	protect	VBG
cord-017585-0llgr357	225	38	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	225	39	-	-	HYPH
cord-017585-0llgr357	225	40	7	7	CD
cord-017585-0llgr357	225	41	)	)	-RRB-
cord-017585-0llgr357	225	42	from	from	IN
cord-017585-0llgr357	225	43	both	both	DT
cord-017585-0llgr357	225	44	neprilysin	neprilysin	NNP
cord-017585-0llgr357	225	45	-	-	HYPH
cord-017585-0llgr357	225	46	and	and	CC
cord-017585-0llgr357	225	47	ACE	ace	NN
cord-017585-0llgr357	225	48	-	-	HYPH
cord-017585-0llgr357	225	49	dependent	dependent	JJ
cord-017585-0llgr357	225	50	degradation	degradation	NN
cord-017585-0llgr357	225	51	within	within	IN
cord-017585-0llgr357	225	52	in	in	IN
cord-017585-0llgr357	225	53	the	the	DT
cord-017585-0llgr357	225	54	kidney	kidney	NN
cord-017585-0llgr357	225	55	.	.	.
cord-017585-0llgr357	226	1	Furthermore	furthermore	RB
cord-017585-0llgr357	226	2	,	,	,
cord-017585-0llgr357	226	3	these	these	DT
cord-017585-0llgr357	226	4	data	datum	NNS
cord-017585-0llgr357	226	5	suggest	suggest	VBP
cord-017585-0llgr357	226	6	an	an	DT
cord-017585-0llgr357	226	7	important	important	JJ
cord-017585-0llgr357	226	8	ability	ability	NN
cord-017585-0llgr357	226	9	of	of	IN
cord-017585-0llgr357	226	10	the	the	DT
cord-017585-0llgr357	226	11	dual	dual	JJ
cord-017585-0llgr357	226	12	peptidase	peptidase	NN
cord-017585-0llgr357	226	13	inhibitor	inhibitor	NN
cord-017585-0llgr357	226	14	(	(	-LRB-
cord-017585-0llgr357	226	15	as	as	RB
cord-017585-0llgr357	226	16	well	well	RB
cord-017585-0llgr357	226	17	as	as	IN
cord-017585-0llgr357	226	18	the	the	DT
cord-017585-0llgr357	226	19	administration	administration	NN
cord-017585-0llgr357	226	20	of	of	IN
cord-017585-0llgr357	226	21	other	other	JJ
cord-017585-0llgr357	226	22	RAAS	RAAS	NNP
cord-017585-0llgr357	226	23	inhibitors	inhibitor	NNS
cord-017585-0llgr357	226	24	alone	alone	RB
cord-017585-0llgr357	226	25	)	)	-RRB-
cord-017585-0llgr357	226	26	to	to	TO
cord-017585-0llgr357	226	27	restore	restore	VB
cord-017585-0llgr357	226	28	ACE2	ACE2	NNP
cord-017585-0llgr357	226	29	levels	level	NNS
cord-017585-0llgr357	226	30	in	in	IN
cord-017585-0llgr357	226	31	the	the	DT
cord-017585-0llgr357	226	32	hypertensive	hypertensive	JJ
cord-017585-0llgr357	226	33	kidney	kidney	NN
cord-017585-0llgr357	226	34	which	which	WDT
cord-017585-0llgr357	226	35	may	may	MD
cord-017585-0llgr357	226	36	mitigate	mitigate	VB
cord-017585-0llgr357	226	37	against	against	IN
cord-017585-0llgr357	226	38	the	the	DT
cord-017585-0llgr357	226	39	Ang	Ang	NNP
cord-017585-0llgr357	226	40	II	II	NNP
cord-017585-0llgr357	226	41	-	-	HYPH
cord-017585-0llgr357	226	42	AT	at	NN
cord-017585-0llgr357	226	43	1	1	CD
cord-017585-0llgr357	226	44	receptor	receptor	NN
cord-017585-0llgr357	226	45	axis	axis	NN
cord-017585-0llgr357	226	46	of	of	IN
cord-017585-0llgr357	226	47	the	the	DT
cord-017585-0llgr357	226	48	RAAS	raa	NNS
cord-017585-0llgr357	226	49	.	.	.
cord-017585-0llgr357	227	1	Indeed	indeed	RB
cord-017585-0llgr357	227	2	,	,	,
cord-017585-0llgr357	227	3	Raizada	Raizada	NNP
cord-017585-0llgr357	227	4	and	and	CC
cord-017585-0llgr357	227	5	colleagues	colleague	NNS
cord-017585-0llgr357	227	6	show	show	VBP
cord-017585-0llgr357	227	7	that	that	IN
cord-017585-0llgr357	227	8	lenti	lenti	JJ
cord-017585-0llgr357	227	9	-	-	JJ
cord-017585-0llgr357	227	10	viral	viral	JJ
cord-017585-0llgr357	227	11	expression	expression	NN
cord-017585-0llgr357	227	12	of	of	IN
cord-017585-0llgr357	227	13	ACE2	ACE2	NNP
cord-017585-0llgr357	227	14	has	have	VBZ
cord-017585-0llgr357	227	15	amelioratory	amelioratory	NN
cord-017585-0llgr357	227	16	effects	effect	NNS
cord-017585-0llgr357	227	17	on	on	IN
cord-017585-0llgr357	227	18	blood	blood	NN
cord-017585-0llgr357	227	19	pressure	pressure	NN
cord-017585-0llgr357	227	20	and	and	CC
cord-017585-0llgr357	227	21	cardiac	cardiac	JJ
cord-017585-0llgr357	227	22	fibrosis	fibrosis	NN
cord-017585-0llgr357	227	23	in	in	IN
cord-017585-0llgr357	227	24	the	the	DT
cord-017585-0llgr357	227	25	SHR	SHR	NNP
cord-017585-0llgr357	227	26	,	,	,
cord-017585-0llgr357	227	27	although	although	IN
cord-017585-0llgr357	227	28	the	the	DT
cord-017585-0llgr357	227	29	renal	renal	JJ
cord-017585-0llgr357	227	30	effects	effect	NNS
cord-017585-0llgr357	227	31	of	of	IN
cord-017585-0llgr357	227	32	enhanced	enhance	VBN
cord-017585-0llgr357	227	33	enzyme	enzyme	NN
cord-017585-0llgr357	227	34	activity	activity	NN
cord-017585-0llgr357	227	35	were	be	VBD
cord-017585-0llgr357	227	36	not	not	RB
cord-017585-0llgr357	227	37	ascertained	ascertain	VBN
cord-017585-0llgr357	228	1	(	(	-LRB-
cord-017585-0llgr357	228	2	Diez	Diez	NNP
cord-017585-0llgr357	228	3	-	-	HYPH
cord-017585-0llgr357	228	4	Freire	Freire	NNP
cord-017585-0llgr357	228	5	et	et	NNP
cord-017585-0llgr357	228	6	al	al	NNP
cord-017585-0llgr357	228	7	2006	2006	CD
cord-017585-0llgr357	228	8	)	)	-RRB-
cord-017585-0llgr357	228	9	.	.	.
cord-017585-0llgr357	229	1	Their	-PRON-	PRP$
cord-017585-0llgr357	229	2	data	datum	NNS
cord-017585-0llgr357	229	3	clearly	clearly	RB
cord-017585-0llgr357	229	4	demonstrate	demonstrate	VBP
cord-017585-0llgr357	229	5	that	that	IN
cord-017585-0llgr357	229	6	ACE2	ACE2	NNP
cord-017585-0llgr357	229	7	can	can	MD
cord-017585-0llgr357	229	8	markedly	markedly	RB
cord-017585-0llgr357	229	9	alter	alter	VB
cord-017585-0llgr357	229	10	the	the	DT
cord-017585-0llgr357	229	11	balance	balance	NN
cord-017585-0llgr357	229	12	of	of	IN
cord-017585-0llgr357	229	13	an	an	DT
cord-017585-0llgr357	229	14	activated	activate	VBN
cord-017585-0llgr357	229	15	RAAS	RAAS	NNP
cord-017585-0llgr357	229	16	pathway	pathway	NN
cord-017585-0llgr357	229	17	towards	towards	IN
cord-017585-0llgr357	229	18	a	a	DT
cord-017585-0llgr357	229	19	normotensive	normotensive	JJ
cord-017585-0llgr357	229	20	phenotype	phenotype	NN
cord-017585-0llgr357	229	21	.	.	.
cord-017585-0llgr357	230	1	Further	further	JJ
cord-017585-0llgr357	230	2	study	study	NN
cord-017585-0llgr357	230	3	is	be	VBZ
cord-017585-0llgr357	230	4	required	require	VBN
cord-017585-0llgr357	230	5	to	to	TO
cord-017585-0llgr357	230	6	determine	determine	VB
cord-017585-0llgr357	230	7	the	the	DT
cord-017585-0llgr357	230	8	extent	extent	NN
cord-017585-0llgr357	230	9	that	that	IN
cord-017585-0llgr357	230	10	the	the	DT
cord-017585-0llgr357	230	11	beneficial	beneficial	JJ
cord-017585-0llgr357	230	12	actions	action	NNS
cord-017585-0llgr357	230	13	of	of	IN
cord-017585-0llgr357	230	14	increased	increase	VBN
cord-017585-0llgr357	230	15	ACE2	ACE2	NNP
cord-017585-0llgr357	230	16	reflect	reflect	VBP
cord-017585-0llgr357	230	17	the	the	DT
cord-017585-0llgr357	230	18	greater	great	JJR
cord-017585-0llgr357	230	19	inhibition	inhibition	NN
cord-017585-0llgr357	230	20	of	of	IN
cord-017585-0llgr357	230	21	Ang	Ang	NNP
cord-017585-0llgr357	230	22	II	II	NNP
cord-017585-0llgr357	230	23	or	or	CC
cord-017585-0llgr357	230	24	the	the	DT
cord-017585-0llgr357	230	25	increased	increase	VBN
cord-017585-0llgr357	230	26	accumulation	accumulation	NN
cord-017585-0llgr357	230	27	of	of	IN
cord-017585-0llgr357	230	28	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	230	29	-	-	HYPH
cord-017585-0llgr357	230	30	7	7	CD
cord-017585-0llgr357	230	31	)	)	-RRB-
cord-017585-0llgr357	230	32	in	in	IN
cord-017585-0llgr357	230	33	the	the	DT
cord-017585-0llgr357	230	34	kidney	kidney	NN
cord-017585-0llgr357	230	35	or	or	CC
cord-017585-0llgr357	230	36	other	other	JJ
cord-017585-0llgr357	230	37	tissue	tissue	NN
cord-017585-0llgr357	230	38	.	.	.
cord-017585-0llgr357	231	1	The	the	DT
cord-017585-0llgr357	231	2	positive	positive	JJ
cord-017585-0llgr357	231	3	influence	influence	NN
cord-017585-0llgr357	231	4	of	of	IN
cord-017585-0llgr357	231	5	ACE2	ACE2	NNP
cord-017585-0llgr357	231	6	in	in	IN
cord-017585-0llgr357	231	7	the	the	DT
cord-017585-0llgr357	231	8	SHR	SHR	NNP
cord-017585-0llgr357	231	9	kidney	kidney	NN
cord-017585-0llgr357	231	10	following	follow	VBG
cord-017585-0llgr357	231	11	blockade	blockade	NN
cord-017585-0llgr357	231	12	of	of	IN
cord-017585-0llgr357	231	13	ACE	ACE	NNP
cord-017585-0llgr357	231	14	and	and	CC
cord-017585-0llgr357	231	15	neprilysin	neprilysin	NNP
cord-017585-0llgr357	231	16	emphasizes	emphasize	VBZ
cord-017585-0llgr357	231	17	the	the	DT
cord-017585-0llgr357	231	18	complex	complex	JJ
cord-017585-0llgr357	231	19	regulation	regulation	NN
cord-017585-0llgr357	231	20	of	of	IN
cord-017585-0llgr357	231	21	RAAS	RAAS	NNP
cord-017585-0llgr357	231	22	components	component	NNS
cord-017585-0llgr357	231	23	within	within	IN
cord-017585-0llgr357	231	24	the	the	DT
cord-017585-0llgr357	231	25	kidney	kidney	NN
cord-017585-0llgr357	231	26	(	(	-LRB-
cord-017585-0llgr357	231	27	see	see	VB
cord-017585-0llgr357	231	28	Fig	Fig	NNP
cord-017585-0llgr357	231	29	.	.	.
cord-017585-0llgr357	231	30	6	6	CD
cord-017585-0llgr357	231	31	)	)	-RRB-
cord-017585-0llgr357	231	32	.	.	.
cord-017585-0llgr357	232	1	We	-PRON-	PRP
cord-017585-0llgr357	232	2	have	have	VBP
cord-017585-0llgr357	232	3	also	also	RB
cord-017585-0llgr357	232	4	shown	show	VBN
cord-017585-0llgr357	232	5	that	that	IN
cord-017585-0llgr357	232	6	ACE	ace	NN
cord-017585-0llgr357	232	7	inhibition	inhibition	NN
cord-017585-0llgr357	232	8	alone	alone	RB
cord-017585-0llgr357	232	9	or	or	CC
cord-017585-0llgr357	232	10	AT	at	IN
cord-017585-0llgr357	232	11	1	1	CD
cord-017585-0llgr357	232	12	receptor	receptor	NN
cord-017585-0llgr357	232	13	antagonism	antagonism	NN
cord-017585-0llgr357	232	14	increases	increase	VBZ
cord-017585-0llgr357	232	15	either	either	CC
cord-017585-0llgr357	232	16	renal	renal	JJ
cord-017585-0llgr357	232	17	ACE2	ACE2	NNP
cord-017585-0llgr357	232	18	mRNA	mrna	NN
cord-017585-0llgr357	232	19	or	or	CC
cord-017585-0llgr357	232	20	activity	activity	NN
cord-017585-0llgr357	233	1	(	(	-LRB-
cord-017585-0llgr357	233	2	Igase	Igase	NNP
cord-017585-0llgr357	233	3	et	et	NNP
cord-017585-0llgr357	233	4	al	al	NNP
cord-017585-0llgr357	233	5	2005	2005	CD
cord-017585-0llgr357	233	6	;	;	:
cord-017585-0llgr357	233	7	Ferrario	Ferrario	NNP
cord-017585-0llgr357	233	8	et	et	NNP
cord-017585-0llgr357	233	9	al	al	NNP
cord-017585-0llgr357	233	10	2005b	2005b	CD
cord-017585-0llgr357	233	11	)	)	-RRB-
cord-017585-0llgr357	233	12	.	.	.
cord-017585-0llgr357	234	1	Consistent	consistent	JJ
cord-017585-0llgr357	234	2	with	with	IN
cord-017585-0llgr357	234	3	these	these	DT
cord-017585-0llgr357	234	4	data	datum	NNS
cord-017585-0llgr357	234	5	in	in	IN
cord-017585-0llgr357	234	6	the	the	DT
cord-017585-0llgr357	234	7	intact	intact	JJ
cord-017585-0llgr357	234	8	animal	animal	NN
cord-017585-0llgr357	234	9	,	,	,
cord-017585-0llgr357	234	10	Gallagher	Gallagher	NNP
cord-017585-0llgr357	234	11	Figure	Figure	NNP
cord-017585-0llgr357	234	12	6	6	CD
cord-017585-0llgr357	234	13	.	.	.
cord-017585-0llgr357	235	1	A	a	DT
cord-017585-0llgr357	235	2	potential	potential	JJ
cord-017585-0llgr357	235	3	regulatory	regulatory	JJ
cord-017585-0llgr357	235	4	scheme	scheme	NN
cord-017585-0llgr357	235	5	for	for	IN
cord-017585-0llgr357	235	6	the	the	DT
cord-017585-0llgr357	235	7	stimulatory	stimulatory	JJ
cord-017585-0llgr357	235	8	and	and	CC
cord-017585-0llgr357	235	9	inhibitory	inhibitory	JJ
cord-017585-0llgr357	235	10	pathways	pathway	NNS
cord-017585-0llgr357	235	11	of	of	IN
cord-017585-0llgr357	235	12	the	the	DT
cord-017585-0llgr357	235	13	reninangiotensin	reninangiotensin	JJ
cord-017585-0llgr357	235	14	-	-	HYPH
cord-017585-0llgr357	235	15	aldosterone	aldosterone	NN
cord-017585-0llgr357	235	16	system	system	NN
cord-017585-0llgr357	235	17	within	within	IN
cord-017585-0llgr357	235	18	the	the	DT
cord-017585-0llgr357	235	19	kidney	kidney	NN
cord-017585-0llgr357	235	20	.	.	.
cord-017585-0llgr357	236	1	ACE	ace	NN
cord-017585-0llgr357	236	2	,	,	,
cord-017585-0llgr357	236	3	angiotensin	angiotensin	NN
cord-017585-0llgr357	236	4	converting	convert	VBG
cord-017585-0llgr357	236	5	enzymes	enzyme	NNS
cord-017585-0llgr357	236	6	;	;	:
cord-017585-0llgr357	236	7	Aogen	Aogen	NNP
cord-017585-0llgr357	236	8	,	,	,
cord-017585-0llgr357	236	9	angiotensinogen	angiotensinogen	NNP
cord-017585-0llgr357	236	10	;	;	:
cord-017585-0llgr357	236	11	Aldo	Aldo	NNP
cord-017585-0llgr357	236	12	,	,	,
cord-017585-0llgr357	236	13	aldosterone	aldosterone	NN
cord-017585-0llgr357	236	14	;	;	:
cord-017585-0llgr357	236	15	AT	at	IN
cord-017585-0llgr357	236	16	1	1	CD
cord-017585-0llgr357	236	17	R	r	NN
cord-017585-0llgr357	236	18	,	,	,
cord-017585-0llgr357	236	19	angiotensin	angiotensin	NN
cord-017585-0llgr357	236	20	type	type	NN
cord-017585-0llgr357	236	21	1	1	CD
cord-017585-0llgr357	236	22	receptor	receptor	NN
cord-017585-0llgr357	236	23	;	;	:
cord-017585-0llgr357	236	24	JG	JG	NNP
cord-017585-0llgr357	236	25	,	,	,
cord-017585-0llgr357	236	26	juxtaglomerular	juxtaglomerular	NNP
cord-017585-0llgr357	236	27	and	and	CC
cord-017585-0llgr357	236	28	colleagues	colleague	NNS
cord-017585-0llgr357	237	1	demonstrate	demonstrate	VB
cord-017585-0llgr357	237	2	that	that	IN
cord-017585-0llgr357	237	3	Ang	Ang	NNP
cord-017585-0llgr357	237	4	II	II	NNP
cord-017585-0llgr357	237	5	directly	directly	RB
cord-017585-0llgr357	237	6	down	down	RB
cord-017585-0llgr357	237	7	regulates	regulate	VBZ
cord-017585-0llgr357	237	8	ACE2	ACE2	NNP
cord-017585-0llgr357	237	9	through	through	IN
cord-017585-0llgr357	237	10	activation	activation	NN
cord-017585-0llgr357	237	11	of	of	IN
cord-017585-0llgr357	237	12	the	the	DT
cord-017585-0llgr357	237	13	AT	AT	NNP
cord-017585-0llgr357	237	14	1	1	CD
cord-017585-0llgr357	237	15	receptor	receptor	NN
cord-017585-0llgr357	237	16	.	.	.
cord-017585-0llgr357	238	1	Although	although	IN
cord-017585-0llgr357	238	2	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	238	3	-	-	HYPH
cord-017585-0llgr357	238	4	7	7	CD
cord-017585-0llgr357	238	5	)	)	-RRB-
cord-017585-0llgr357	238	6	alone	alone	RB
cord-017585-0llgr357	238	7	did	do	VBD
cord-017585-0llgr357	238	8	not	not	RB
cord-017585-0llgr357	238	9	influence	influence	VB
cord-017585-0llgr357	238	10	the	the	DT
cord-017585-0llgr357	238	11	basal	basal	JJ
cord-017585-0llgr357	238	12	expression	expression	NN
cord-017585-0llgr357	238	13	of	of	IN
cord-017585-0llgr357	238	14	ACE2	ACE2	NNP
cord-017585-0llgr357	238	15	in	in	IN
cord-017585-0llgr357	238	16	these	these	DT
cord-017585-0llgr357	238	17	cells	cell	NNS
cord-017585-0llgr357	238	18	,	,	,
cord-017585-0llgr357	238	19	the	the	DT
cord-017585-0llgr357	238	20	peptide	peptide	NN
cord-017585-0llgr357	238	21	attenuated	attenuate	VBD
cord-017585-0llgr357	238	22	the	the	DT
cord-017585-0llgr357	238	23	inhibitory	inhibitory	JJ
cord-017585-0llgr357	238	24	effects	effect	NNS
cord-017585-0llgr357	238	25	of	of	IN
cord-017585-0llgr357	238	26	Ang	Ang	NNP
cord-017585-0llgr357	238	27	II	II	NNP
cord-017585-0llgr357	238	28	on	on	IN
cord-017585-0llgr357	238	29	ACE2	ACE2	NNP
cord-017585-0llgr357	238	30	via	via	IN
cord-017585-0llgr357	238	31	a	a	DT
cord-017585-0llgr357	238	32	receptor	receptor	NN
cord-017585-0llgr357	238	33	-	-	HYPH
cord-017585-0llgr357	238	34	dependent	dependent	JJ
cord-017585-0llgr357	238	35	mechanism	mechanism	NN
cord-017585-0llgr357	238	36	.	.	.
cord-017585-0llgr357	239	1	In	in	IN
cord-017585-0llgr357	239	2	contrast	contrast	NN
cord-017585-0llgr357	239	3	to	to	IN
cord-017585-0llgr357	239	4	the	the	DT
cord-017585-0llgr357	239	5	negative	negative	JJ
cord-017585-0llgr357	239	6	influence	influence	NN
cord-017585-0llgr357	239	7	on	on	IN
cord-017585-0llgr357	239	8	ACE2	ACE2	NNP
cord-017585-0llgr357	239	9	,	,	,
cord-017585-0llgr357	239	10	Ang	Ang	NNP
cord-017585-0llgr357	239	11	II	II	NNP
cord-017585-0llgr357	239	12	increases	increase	VBZ
cord-017585-0llgr357	239	13	ACE	ACE	NNP
cord-017585-0llgr357	239	14	expression	expression	NN
cord-017585-0llgr357	239	15	within	within	IN
cord-017585-0llgr357	239	16	the	the	DT
cord-017585-0llgr357	239	17	kidney	kidney	NN
cord-017585-0llgr357	239	18	Sadjadi	Sadjadi	NNP
cord-017585-0llgr357	239	19	et	et	NNP
cord-017585-0llgr357	239	20	al	al	NNP
cord-017585-0llgr357	239	21	2005b	2005b	CD
cord-017585-0llgr357	239	22	)	)	-RRB-
cord-017585-0llgr357	239	23	.	.	.
cord-017585-0llgr357	240	1	Ang	Ang	NNP
cord-017585-0llgr357	240	2	II	II	NNP
cord-017585-0llgr357	240	3	also	also	RB
cord-017585-0llgr357	240	4	positively	positively	RB
cord-017585-0llgr357	240	5	influences	influence	VBZ
cord-017585-0llgr357	240	6	the	the	DT
cord-017585-0llgr357	240	7	expression	expression	NN
cord-017585-0llgr357	240	8	of	of	IN
cord-017585-0llgr357	240	9	its	-PRON-	PRP$
cord-017585-0llgr357	240	10	precursor	precursor	NN
cord-017585-0llgr357	240	11	protein	protein	NN
cord-017585-0llgr357	240	12	angiotensinogen	angiotensinogen	NNP
cord-017585-0llgr357	240	13	(	(	-LRB-
cord-017585-0llgr357	240	14	Kobori	Kobori	NNP
cord-017585-0llgr357	240	15	et	et	NNP
cord-017585-0llgr357	240	16	al	al	NNP
cord-017585-0llgr357	240	17	2001	2001	CD
cord-017585-0llgr357	240	18	;	;	:
cord-017585-0llgr357	240	19	Zhang	Zhang	NNP
cord-017585-0llgr357	240	20	et	et	NNP
cord-017585-0llgr357	240	21	al	al	NNP
cord-017585-0llgr357	240	22	2002	2002	CD
cord-017585-0llgr357	240	23	)	)	-RRB-
cord-017585-0llgr357	240	24	,	,	,
cord-017585-0llgr357	240	25	and	and	CC
cord-017585-0llgr357	240	26	in	in	IN
cord-017585-0llgr357	240	27	selective	selective	JJ
cord-017585-0llgr357	240	28	areas	area	NNS
cord-017585-0llgr357	240	29	of	of	IN
cord-017585-0llgr357	240	30	the	the	DT
cord-017585-0llgr357	240	31	kidney	kidney	NN
cord-017585-0llgr357	240	32	,	,	,
cord-017585-0llgr357	240	33	either	either	CC
cord-017585-0llgr357	240	34	maintains	maintain	VBZ
cord-017585-0llgr357	240	35	or	or	CC
cord-017585-0llgr357	240	36	up	up	RB
cord-017585-0llgr357	240	37	regulates	regulate	VBZ
cord-017585-0llgr357	240	38	the	the	DT
cord-017585-0llgr357	240	39	AT	AT	NNP
cord-017585-0llgr357	240	40	1	1	CD
cord-017585-0llgr357	240	41	receptor	receptor	NN
cord-017585-0llgr357	240	42	as	as	RB
cord-017585-0llgr357	240	43	well	well	RB
cord-017585-0llgr357	240	44	.	.	.
cord-017585-0llgr357	241	1	This	this	DT
cord-017585-0llgr357	241	2	effect	effect	NN
cord-017585-0llgr357	241	3	on	on	IN
cord-017585-0llgr357	241	4	the	the	DT
cord-017585-0llgr357	241	5	AT	AT	NNP
cord-017585-0llgr357	241	6	1	1	CD
cord-017585-0llgr357	241	7	receptor	receptor	NN
cord-017585-0llgr357	241	8	may	may	MD
cord-017585-0llgr357	241	9	also	also	RB
cord-017585-0llgr357	241	10	lead	lead	VB
cord-017585-0llgr357	241	11	to	to	IN
cord-017585-0llgr357	241	12	increased	increase	VBN
cord-017585-0llgr357	241	13	renal	renal	JJ
cord-017585-0llgr357	241	14	levels	level	NNS
cord-017585-0llgr357	241	15	of	of	IN
cord-017585-0llgr357	241	16	Ang	Ang	NNP
cord-017585-0llgr357	241	17	II	II	NNP
cord-017585-0llgr357	241	18	via	via	IN
cord-017585-0llgr357	241	19	receptor	receptor	NN
cord-017585-0llgr357	241	20	mediated	mediate	VBN
cord-017585-0llgr357	241	21	uptake	uptake	NN
cord-017585-0llgr357	241	22	and	and	CC
cord-017585-0llgr357	241	23	stable	stable	JJ
cord-017585-0llgr357	241	24	sequestration	sequestration	NN
cord-017585-0llgr357	241	25	of	of	IN
cord-017585-0llgr357	241	26	the	the	DT
cord-017585-0llgr357	241	27	circulating	circulate	VBG
cord-017585-0llgr357	241	28	peptide	peptide	NN
cord-017585-0llgr357	241	29	(	(	-LRB-
cord-017585-0llgr357	241	30	Ingert	Ingert	NNP
cord-017585-0llgr357	241	31	et	et	FW
cord-017585-0llgr357	241	32	al	al	NNP
cord-017585-0llgr357	241	33	2002	2002	CD
cord-017585-0llgr357	241	34	)	)	-RRB-
cord-017585-0llgr357	241	35	.	.	.
cord-017585-0llgr357	242	1	In	in	IN
cord-017585-0llgr357	242	2	contrast	contrast	NN
cord-017585-0llgr357	242	3	,	,	,
cord-017585-0llgr357	242	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	242	5	-	-	HYPH
cord-017585-0llgr357	242	6	7	7	NNP
cord-017585-0llgr357	242	7	)	)	-RRB-
cord-017585-0llgr357	242	8	can	can	MD
cord-017585-0llgr357	242	9	down	down	RP
cord-017585-0llgr357	242	10	regulate	regulate	VB
cord-017585-0llgr357	242	11	the	the	DT
cord-017585-0llgr357	242	12	AT	AT	NNP
cord-017585-0llgr357	242	13	1	1	CD
cord-017585-0llgr357	242	14	receptor	receptor	NN
cord-017585-0llgr357	242	15	through	through	IN
cord-017585-0llgr357	242	16	stimulation	stimulation	NN
cord-017585-0llgr357	242	17	of	of	IN
cord-017585-0llgr357	242	18	a	a	DT
cord-017585-0llgr357	242	19	cylocoxygenase	cylocoxygenase	JJ
cord-017585-0llgr357	242	20	pathway	pathway	NN
cord-017585-0llgr357	242	21	(	(	-LRB-
cord-017585-0llgr357	242	22	Clark	Clark	NNP
cord-017585-0llgr357	242	23	et	et	NNP
cord-017585-0llgr357	242	24	al	al	NNP
cord-017585-0llgr357	242	25	2003	2003	CD
cord-017585-0llgr357	242	26	;	;	:
cord-017585-0llgr357	242	27	Clark	Clark	NNP
cord-017585-0llgr357	242	28	et	et	NNP
cord-017585-0llgr357	242	29	al	al	NNP
cord-017585-0llgr357	242	30	2001	2001	CD
cord-017585-0llgr357	242	31	)	)	-RRB-
cord-017585-0llgr357	242	32	.	.	.
cord-017585-0llgr357	243	1	There	there	EX
cord-017585-0llgr357	243	2	are	be	VBP
cord-017585-0llgr357	243	3	few	few	JJ
cord-017585-0llgr357	243	4	studies	study	NNS
cord-017585-0llgr357	243	5	on	on	IN
cord-017585-0llgr357	243	6	the	the	DT
cord-017585-0llgr357	243	7	regulation	regulation	NN
cord-017585-0llgr357	243	8	of	of	IN
cord-017585-0llgr357	243	9	the	the	DT
cord-017585-0llgr357	243	10	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	243	11	-	-	HYPH
cord-017585-0llgr357	243	12	7	7	CD
cord-017585-0llgr357	243	13	)	)	-RRB-
cord-017585-0llgr357	243	14	receptor	receptor	NN
cord-017585-0llgr357	243	15	,	,	,
cord-017585-0llgr357	243	16	although	although	IN
cord-017585-0llgr357	243	17	chronic	chronic	JJ
cord-017585-0llgr357	243	18	ACE	ACE	NNP
cord-017585-0llgr357	243	19	or	or	CC
cord-017585-0llgr357	243	20	AT	at	IN
cord-017585-0llgr357	243	21	1	1	CD
cord-017585-0llgr357	243	22	blockade	blockade	NN
cord-017585-0llgr357	243	23	reduced	reduce	VBN
cord-017585-0llgr357	243	24	mas	mas	NNP
cord-017585-0llgr357	243	25	mRNA	mRNA	NNP
cord-017585-0llgr357	243	26	expression	expression	NN
cord-017585-0llgr357	243	27	in	in	IN
cord-017585-0llgr357	243	28	the	the	DT
cord-017585-0llgr357	243	29	renal	renal	JJ
cord-017585-0llgr357	243	30	cortex	cortex	NN
cord-017585-0llgr357	243	31	of	of	IN
cord-017585-0llgr357	243	32	the	the	DT
cord-017585-0llgr357	243	33	Ren2	Ren2	NNP
cord-017585-0llgr357	243	34	Lewis	Lewis	NNP
cord-017585-0llgr357	243	35	congenic	congenic	NNP
cord-017585-0llgr357	243	36	rat	rat	NN
cord-017585-0llgr357	243	37	.	.	.
cord-017585-0llgr357	244	1	Consistent	consistent	JJ
cord-017585-0llgr357	244	2	with	with	IN
cord-017585-0llgr357	244	3	the	the	DT
cord-017585-0llgr357	244	4	positive	positive	JJ
cord-017585-0llgr357	244	5	feedback	feedback	NN
cord-017585-0llgr357	244	6	concept	concept	NN
cord-017585-0llgr357	244	7	,	,	,
cord-017585-0llgr357	244	8	the	the	DT
cord-017585-0llgr357	244	9	current	current	JJ
cord-017585-0llgr357	244	10	evidence	evidence	NN
cord-017585-0llgr357	244	11	suggests	suggest	VBZ
cord-017585-0llgr357	244	12	that	that	IN
cord-017585-0llgr357	244	13	aldosterone	aldosterone	NN
cord-017585-0llgr357	244	14	down	down	RP
cord-017585-0llgr357	244	15	regulates	regulate	VBZ
cord-017585-0llgr357	244	16	ACE2	ACE2	NNP
cord-017585-0llgr357	245	1	(	(	-LRB-
cord-017585-0llgr357	245	2	Keidar	Keidar	NNP
cord-017585-0llgr357	245	3	et	et	NNP
cord-017585-0llgr357	245	4	al	al	NNP
cord-017585-0llgr357	245	5	2005	2005	CD
cord-017585-0llgr357	245	6	;	;	:
cord-017585-0llgr357	246	1	Tallant	Tallant	NNP
cord-017585-0llgr357	246	2	et	et	FW
cord-017585-0llgr357	246	3	al	al	NNP
cord-017585-0llgr357	246	4	2005b	2005b	CD
cord-017585-0llgr357	246	5	)	)	-RRB-
cord-017585-0llgr357	247	1	while	while	IN
cord-017585-0llgr357	247	2	the	the	DT
cord-017585-0llgr357	247	3	mineralocorticoid	mineralocorticoid	NN
cord-017585-0llgr357	247	4	increases	increase	VBZ
cord-017585-0llgr357	247	5	expression	expression	NN
cord-017585-0llgr357	247	6	of	of	IN
cord-017585-0llgr357	247	7	ACE	ACE	NNP
cord-017585-0llgr357	247	8	,	,	,
cord-017585-0llgr357	247	9	AT	at	IN
cord-017585-0llgr357	247	10	1	1	CD
cord-017585-0llgr357	247	11	receptor	receptor	NN
cord-017585-0llgr357	247	12	,	,	,
cord-017585-0llgr357	247	13	renin	renin	NN
cord-017585-0llgr357	247	14	and	and	CC
cord-017585-0llgr357	247	15	intrarenal	intrarenal	NNP
cord-017585-0llgr357	247	16	Ang	Ang	NNP
cord-017585-0llgr357	247	17	II	II	NNP
cord-017585-0llgr357	248	1	(	(	-LRB-
cord-017585-0llgr357	248	2	Bayorh	Bayorh	NNP
cord-017585-0llgr357	248	3	et	et	NNP
cord-017585-0llgr357	248	4	al	al	NNP
cord-017585-0llgr357	248	5	2006	2006	CD
cord-017585-0llgr357	248	6	;	;	:
cord-017585-0llgr357	248	7	Klar	Klar	NNP
cord-017585-0llgr357	248	8	et	et	NNP
cord-017585-0llgr357	248	9	al	al	NNP
cord-017585-0llgr357	248	10	2004	2004	CD
cord-017585-0llgr357	248	11	;	;	:
cord-017585-0llgr357	248	12	Schiffrin	Schiffrin	NNP
cord-017585-0llgr357	248	13	2006	2006	CD
cord-017585-0llgr357	248	14	)	)	-RRB-
cord-017585-0llgr357	248	15	.	.	.
cord-017585-0llgr357	249	1	Thus	thus	RB
cord-017585-0llgr357	249	2	,	,	,
cord-017585-0llgr357	249	3	the	the	DT
cord-017585-0llgr357	249	4	renal	renal	JJ
cord-017585-0llgr357	249	5	RAAS	RAAS	NNP
cord-017585-0llgr357	249	6	appears	appear	VBZ
cord-017585-0llgr357	249	7	to	to	TO
cord-017585-0llgr357	249	8	function	function	VB
cord-017585-0llgr357	249	9	in	in	IN
cord-017585-0llgr357	249	10	a	a	DT
cord-017585-0llgr357	249	11	positive	positive	JJ
cord-017585-0llgr357	249	12	regulatory	regulatory	JJ
cord-017585-0llgr357	249	13	manner	manner	NN
cord-017585-0llgr357	249	14	on	on	IN
cord-017585-0llgr357	249	15	these	these	DT
cord-017585-0llgr357	249	16	components	component	NNS
cord-017585-0llgr357	249	17	to	to	TO
cord-017585-0llgr357	249	18	promote	promote	VB
cord-017585-0llgr357	249	19	or	or	CC
cord-017585-0llgr357	249	20	maintain	maintain	VB
cord-017585-0llgr357	249	21	Ang	Ang	NNP
cord-017585-0llgr357	249	22	II	II	NNP
cord-017585-0llgr357	249	23	content	content	NN
cord-017585-0llgr357	249	24	.	.	.
cord-017585-0llgr357	250	1	In	in	IN
cord-017585-0llgr357	250	2	this	this	DT
cord-017585-0llgr357	250	3	regard	regard	NN
cord-017585-0llgr357	250	4	,	,	,
cord-017585-0llgr357	250	5	ACE2	ACE2	NNP
cord-017585-0llgr357	250	6	may	may	MD
cord-017585-0llgr357	250	7	serve	serve	VB
cord-017585-0llgr357	250	8	as	as	IN
cord-017585-0llgr357	250	9	an	an	DT
cord-017585-0llgr357	250	10	important	important	JJ
cord-017585-0llgr357	250	11	mechanism	mechanism	NN
cord-017585-0llgr357	250	12	to	to	TO
cord-017585-0llgr357	250	13	break	break	VB
cord-017585-0llgr357	250	14	or	or	CC
cord-017585-0llgr357	250	15	reduce	reduce	VB
cord-017585-0llgr357	250	16	the	the	DT
cord-017585-0llgr357	250	17	positive	positive	JJ
cord-017585-0llgr357	250	18	gain	gain	NN
cord-017585-0llgr357	250	19	of	of	IN
cord-017585-0llgr357	250	20	the	the	DT
cord-017585-0llgr357	250	21	system	system	NN
cord-017585-0llgr357	250	22	for	for	IN
cord-017585-0llgr357	250	23	Ang	Ang	NNP
cord-017585-0llgr357	250	24	II	II	NNP
cord-017585-0llgr357	250	25	production	production	NN
cord-017585-0llgr357	250	26	or	or	CC
cord-017585-0llgr357	250	27	enhanced	enhance	VBN
cord-017585-0llgr357	250	28	signaling	signaling	NN
cord-017585-0llgr357	250	29	in	in	IN
cord-017585-0llgr357	250	30	the	the	DT
cord-017585-0llgr357	250	31	kidney	kidney	NN
cord-017585-0llgr357	250	32	.	.	.
cord-017585-0llgr357	251	1	Although	although	IN
cord-017585-0llgr357	251	2	Ang	Ang	NNP
cord-017585-0llgr357	251	3	II	II	NNP
cord-017585-0llgr357	251	4	potently	potently	RB
cord-017585-0llgr357	251	5	reduces	reduce	VBZ
cord-017585-0llgr357	251	6	juxtaglomerular	juxtaglomerular	NNP
cord-017585-0llgr357	251	7	(	(	-LRB-
cord-017585-0llgr357	251	8	JG)derived	JG)derived	NNP
cord-017585-0llgr357	251	9	release	release	NN
cord-017585-0llgr357	251	10	and	and	CC
cord-017585-0llgr357	251	11	expression	expression	NN
cord-017585-0llgr357	251	12	of	of	IN
cord-017585-0llgr357	251	13	renin	renin	NN
cord-017585-0llgr357	251	14	,	,	,
cord-017585-0llgr357	251	15	renin	renin	NN
cord-017585-0llgr357	251	16	is	be	VBZ
cord-017585-0llgr357	251	17	not	not	RB
cord-017585-0llgr357	251	18	suppressed	suppress	VBN
cord-017585-0llgr357	251	19	but	but	CC
cord-017585-0llgr357	251	20	increases	increase	NNS
cord-017585-0llgr357	251	21	in	in	IN
cord-017585-0llgr357	251	22	the	the	DT
cord-017585-0llgr357	251	23	collecting	collecting	NN
cord-017585-0llgr357	251	24	duct	duct	NN
cord-017585-0llgr357	251	25	and	and	CC
cord-017585-0llgr357	251	26	distal	distal	JJ
cord-017585-0llgr357	251	27	tubules	tubule	NNS
cord-017585-0llgr357	251	28	(	(	-LRB-
cord-017585-0llgr357	251	29	Prieto	Prieto	NNP
cord-017585-0llgr357	251	30	-	-	HYPH
cord-017585-0llgr357	251	31	Carrasquero	Carrasquero	NNP
cord-017585-0llgr357	251	32	et	et	NNP
cord-017585-0llgr357	251	33	al	al	NNP
cord-017585-0llgr357	251	34	2004	2004	CD
cord-017585-0llgr357	251	35	)	)	-RRB-
cord-017585-0llgr357	251	36	.	.	.
cord-017585-0llgr357	252	1	The	the	DT
cord-017585-0llgr357	252	2	negative	negative	JJ
cord-017585-0llgr357	252	3	feedback	feedback	NN
cord-017585-0llgr357	252	4	by	by	IN
cord-017585-0llgr357	252	5	Ang	Ang	NNP
cord-017585-0llgr357	252	6	II	II	NNP
cord-017585-0llgr357	252	7	on	on	IN
cord-017585-0llgr357	252	8	JG	JG	NNP
cord-017585-0llgr357	252	9	renin	renin	NN
cord-017585-0llgr357	252	10	may	may	MD
cord-017585-0llgr357	252	11	also	also	RB
cord-017585-0llgr357	252	12	be	be	VB
cord-017585-0llgr357	252	13	balanced	balance	VBN
cord-017585-0llgr357	252	14	by	by	IN
cord-017585-0llgr357	252	15	renin	renin	NN
cord-017585-0llgr357	252	16	-	-	HYPH
cord-017585-0llgr357	252	17	independent	independent	JJ
cord-017585-0llgr357	252	18	pathways	pathway	NNS
cord-017585-0llgr357	252	19	that	that	WDT
cord-017585-0llgr357	252	20	contribute	contribute	VBP
cord-017585-0llgr357	252	21	to	to	IN
cord-017585-0llgr357	252	22	the	the	DT
cord-017585-0llgr357	252	23	formation	formation	NN
cord-017585-0llgr357	252	24	of	of	IN
cord-017585-0llgr357	252	25	Ang	Ang	NNP
cord-017585-0llgr357	252	26	I.	I.	NNP
cord-017585-0llgr357	252	27	Alternatively	Alternatively	NNP
cord-017585-0llgr357	252	28	,	,	,
cord-017585-0llgr357	252	29	Nagata	Nagata	NNP
cord-017585-0llgr357	252	30	and	and	CC
cord-017585-0llgr357	252	31	colleagues	colleague	NNS
cord-017585-0llgr357	252	32	(	(	-LRB-
cord-017585-0llgr357	252	33	Nagata	Nagata	NNP
cord-017585-0llgr357	252	34	et	et	NNP
cord-017585-0llgr357	252	35	al	al	NNP
cord-017585-0llgr357	252	36	2006	2006	CD
cord-017585-0llgr357	252	37	)	)	-RRB-
cord-017585-0llgr357	252	38	find	find	VBP
cord-017585-0llgr357	252	39	significant	significant	JJ
cord-017585-0llgr357	252	40	concentrations	concentration	NNS
cord-017585-0llgr357	252	41	of	of	IN
cord-017585-0llgr357	252	42	the	the	DT
cord-017585-0llgr357	252	43	novel	novel	JJ
cord-017585-0llgr357	252	44	peptide	peptide	NN
cord-017585-0llgr357	252	45	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	252	46	-	-	HYPH
cord-017585-0llgr357	252	47	12	12	CD
cord-017585-0llgr357	252	48	)	)	-RRB-
cord-017585-0llgr357	252	49	in	in	IN
cord-017585-0llgr357	252	50	the	the	DT
cord-017585-0llgr357	252	51	kidney	kidney	NN
cord-017585-0llgr357	252	52	and	and	CC
cord-017585-0llgr357	252	53	other	other	JJ
cord-017585-0llgr357	252	54	tissues	tissue	NNS
cord-017585-0llgr357	252	55	that	that	WDT
cord-017585-0llgr357	252	56	may	may	MD
cord-017585-0llgr357	252	57	not	not	RB
cord-017585-0llgr357	252	58	require	require	VB
cord-017585-0llgr357	252	59	renin	renin	NN
cord-017585-0llgr357	252	60	for	for	IN
cord-017585-0llgr357	252	61	the	the	DT
cord-017585-0llgr357	252	62	peptide	peptide	NN
cord-017585-0llgr357	252	63	's	's	POS
cord-017585-0llgr357	252	64	synthesis	synthesis	NN
cord-017585-0llgr357	252	65	(	(	-LRB-
cord-017585-0llgr357	252	66	see	see	VB
cord-017585-0llgr357	252	67	Fig	Fig	NNP
cord-017585-0llgr357	252	68	.	.	NNP
cord-017585-0llgr357	252	69	1	1	CD
cord-017585-0llgr357	252	70	)	)	-RRB-
cord-017585-0llgr357	252	71	.	.	.
cord-017585-0llgr357	253	1	The	the	DT
cord-017585-0llgr357	253	2	infusion	infusion	NN
cord-017585-0llgr357	253	3	of	of	IN
cord-017585-0llgr357	253	4	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	253	5	-	-	HYPH
cord-017585-0llgr357	253	6	12	12	CD
cord-017585-0llgr357	253	7	)	)	-RRB-
cord-017585-0llgr357	253	8	produced	produce	VBD
cord-017585-0llgr357	253	9	an	an	DT
cord-017585-0llgr357	253	10	immediate	immediate	JJ
cord-017585-0llgr357	253	11	increase	increase	NN
cord-017585-0llgr357	253	12	in	in	IN
cord-017585-0llgr357	253	13	blood	blood	NN
cord-017585-0llgr357	253	14	pressure	pressure	NN
cord-017585-0llgr357	253	15	that	that	WDT
cord-017585-0llgr357	253	16	was	be	VBD
cord-017585-0llgr357	253	17	abolished	abolish	VBN
cord-017585-0llgr357	253	18	by	by	IN
cord-017585-0llgr357	253	19	either	either	CC
cord-017585-0llgr357	253	20	an	an	DT
cord-017585-0llgr357	253	21	ACE	ace	NN
cord-017585-0llgr357	253	22	inhibitor	inhibitor	NN
cord-017585-0llgr357	253	23	or	or	CC
cord-017585-0llgr357	253	24	an	an	DT
cord-017585-0llgr357	253	25	AT	at	NN
cord-017585-0llgr357	253	26	1	1	CD
cord-017585-0llgr357	253	27	receptor	receptor	NN
cord-017585-0llgr357	253	28	antagonist	antagonist	NN
cord-017585-0llgr357	253	29	(	(	-LRB-
cord-017585-0llgr357	253	30	Nagata	Nagata	NNP
cord-017585-0llgr357	253	31	et	et	NNP
cord-017585-0llgr357	253	32	al	al	NNP
cord-017585-0llgr357	253	33	2006	2006	CD
cord-017585-0llgr357	253	34	)	)	-RRB-
cord-017585-0llgr357	253	35	.	.	.
cord-017585-0llgr357	254	1	These	these	DT
cord-017585-0llgr357	254	2	data	datum	NNS
cord-017585-0llgr357	254	3	suggest	suggest	VBP
cord-017585-0llgr357	254	4	that	that	IN
cord-017585-0llgr357	254	5	following	follow	VBG
cord-017585-0llgr357	254	6	formation	formation	NN
cord-017585-0llgr357	254	7	of	of	IN
cord-017585-0llgr357	254	8	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	254	9	-	-	HYPH
cord-017585-0llgr357	254	10	12	12	CD
cord-017585-0llgr357	254	11	)	)	-RRB-
cord-017585-0llgr357	254	12	,	,	,
cord-017585-0llgr357	254	13	the	the	DT
cord-017585-0llgr357	254	14	peptide	peptide	NN
cord-017585-0llgr357	254	15	or	or	CC
cord-017585-0llgr357	254	16	its	-PRON-	PRP$
cord-017585-0llgr357	254	17	intermediate	intermediate	NN
cord-017585-0llgr357	254	18	is	be	VBZ
cord-017585-0llgr357	254	19	converted	convert	VBN
cord-017585-0llgr357	254	20	to	to	IN
cord-017585-0llgr357	254	21	Ang	Ang	NNP
cord-017585-0llgr357	254	22	II	II	NNP
cord-017585-0llgr357	254	23	by	by	IN
cord-017585-0llgr357	254	24	ACE	ACE	NNP
cord-017585-0llgr357	254	25	.	.	.
cord-017585-0llgr357	255	1	The	the	DT
cord-017585-0llgr357	255	2	elucidation	elucidation	NN
cord-017585-0llgr357	255	3	of	of	IN
cord-017585-0llgr357	255	4	the	the	DT
cord-017585-0llgr357	255	5	enzyme(s	enzyme(s	NNP
cord-017585-0llgr357	255	6	)	)	-RRB-
cord-017585-0llgr357	255	7	responsible	responsible	JJ
cord-017585-0llgr357	255	8	for	for	IN
cord-017585-0llgr357	255	9	the	the	DT
cord-017585-0llgr357	255	10	formation	formation	NN
cord-017585-0llgr357	255	11	of	of	IN
cord-017585-0llgr357	255	12	Ang-(1	Ang-(1	NNP
cord-017585-0llgr357	255	13	-	-	HYPH
cord-017585-0llgr357	255	14	12	12	CD
cord-017585-0llgr357	255	15	)	)	-RRB-
cord-017585-0llgr357	255	16	and	and	CC
cord-017585-0llgr357	255	17	the	the	DT
cord-017585-0llgr357	255	18	factors	factor	NNS
cord-017585-0llgr357	255	19	that	that	WDT
cord-017585-0llgr357	255	20	influence	influence	VBP
cord-017585-0llgr357	255	21	its	-PRON-	PRP$
cord-017585-0llgr357	255	22	expression	expression	NN
cord-017585-0llgr357	255	23	may	may	MD
cord-017585-0llgr357	255	24	greatly	greatly	RB
cord-017585-0llgr357	255	25	contribute	contribute	VB
cord-017585-0llgr357	255	26	to	to	IN
cord-017585-0llgr357	255	27	our	-PRON-	PRP$
cord-017585-0llgr357	255	28	understanding	understanding	NN
cord-017585-0llgr357	255	29	the	the	DT
cord-017585-0llgr357	255	30	regulation	regulation	NN
cord-017585-0llgr357	255	31	of	of	IN
cord-017585-0llgr357	255	32	the	the	DT
cord-017585-0llgr357	255	33	intrarenal	intrarenal	JJ
cord-017585-0llgr357	255	34	RAAS	RAAS	NNP
cord-017585-0llgr357	255	35	,	,	,
cord-017585-0llgr357	255	36	particularly	particularly	RB
cord-017585-0llgr357	255	37	under	under	IN
cord-017585-0llgr357	255	38	pathophysiological	pathophysiological	JJ
cord-017585-0llgr357	255	39	conditions	condition	NNS
cord-017585-0llgr357	255	40	.	.	.
cord-017585-0llgr357	256	1	The	the	DT
cord-017585-0llgr357	256	2	majority	majority	NN
cord-017585-0llgr357	256	3	of	of	IN
cord-017585-0llgr357	256	4	experimental	experimental	JJ
cord-017585-0llgr357	256	5	studies	study	NNS
cord-017585-0llgr357	256	6	on	on	IN
cord-017585-0llgr357	256	7	the	the	DT
cord-017585-0llgr357	256	8	RAAS	raa	NNS
cord-017585-0llgr357	256	9	and	and	CC
cord-017585-0llgr357	256	10	the	the	DT
cord-017585-0llgr357	256	11	regulation	regulation	NN
cord-017585-0llgr357	256	12	of	of	IN
cord-017585-0llgr357	256	13	blood	blood	NN
cord-017585-0llgr357	256	14	pressure	pressure	NN
cord-017585-0llgr357	256	15	have	have	VBP
cord-017585-0llgr357	256	16	utilized	utilize	VBN
cord-017585-0llgr357	256	17	male	male	JJ
cord-017585-0llgr357	256	18	animals	animal	NNS
cord-017585-0llgr357	256	19	.	.	.
cord-017585-0llgr357	257	1	As	as	IN
cord-017585-0llgr357	257	2	there	there	EX
cord-017585-0llgr357	257	3	is	be	VBZ
cord-017585-0llgr357	257	4	overwhelming	overwhelming	JJ
cord-017585-0llgr357	257	5	evidence	evidence	NN
cord-017585-0llgr357	257	6	for	for	IN
cord-017585-0llgr357	257	7	sex	sex	NN
cord-017585-0llgr357	257	8	differences	difference	NNS
cord-017585-0llgr357	257	9	in	in	IN
cord-017585-0llgr357	257	10	the	the	DT
cord-017585-0llgr357	257	11	extent	extent	NN
cord-017585-0llgr357	257	12	of	of	IN
cord-017585-0llgr357	257	13	hypertension	hypertension	NN
cord-017585-0llgr357	257	14	and	and	CC
cord-017585-0llgr357	257	15	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	257	16	injury	injury	NN
cord-017585-0llgr357	257	17	,	,	,
cord-017585-0llgr357	257	18	the	the	DT
cord-017585-0llgr357	257	19	consideration	consideration	NN
cord-017585-0llgr357	257	20	of	of	IN
cord-017585-0llgr357	257	21	gender	gender	NN
cord-017585-0llgr357	257	22	in	in	IN
cord-017585-0llgr357	257	23	the	the	DT
cord-017585-0llgr357	257	24	regulation	regulation	NN
cord-017585-0llgr357	257	25	of	of	IN
cord-017585-0llgr357	257	26	the	the	DT
cord-017585-0llgr357	257	27	renal	renal	JJ
cord-017585-0llgr357	257	28	RAAS	RAAS	NNP
cord-017585-0llgr357	257	29	enzyme	enzyme	NN
cord-017585-0llgr357	257	30	cascade	cascade	NN
cord-017585-0llgr357	257	31	should	should	MD
cord-017585-0llgr357	257	32	be	be	VB
cord-017585-0llgr357	257	33	carefully	carefully	RB
cord-017585-0llgr357	257	34	considered	consider	VBN
cord-017585-0llgr357	257	35	(	(	-LRB-
cord-017585-0llgr357	257	36	Bachmann	Bachmann	NNP
cord-017585-0llgr357	257	37	et	et	NNP
cord-017585-0llgr357	257	38	al	al	NNP
cord-017585-0llgr357	257	39	1991	1991	CD
cord-017585-0llgr357	257	40	;	;	:
cord-017585-0llgr357	258	1	Brosnihan	Brosnihan	NNP
cord-017585-0llgr357	258	2	et	et	NNP
cord-017585-0llgr357	258	3	al	al	NNP
cord-017585-0llgr357	258	4	1999	1999	CD
cord-017585-0llgr357	258	5	;	;	:
cord-017585-0llgr357	258	6	Reckelhoff	Reckelhoff	NNP
cord-017585-0llgr357	258	7	et	et	NNP
cord-017585-0llgr357	258	8	al	al	NNP
cord-017585-0llgr357	258	9	2000	2000	CD
cord-017585-0llgr357	258	10	)	)	-RRB-
cord-017585-0llgr357	258	11	.	.	.
cord-017585-0llgr357	259	1	For	for	IN
cord-017585-0llgr357	259	2	example	example	NN
cord-017585-0llgr357	259	3	,	,	,
cord-017585-0llgr357	259	4	the	the	DT
cord-017585-0llgr357	259	5	presence	presence	NN
cord-017585-0llgr357	259	6	of	of	IN
cord-017585-0llgr357	259	7	renal	renal	JJ
cord-017585-0llgr357	259	8	damage	damage	NN
cord-017585-0llgr357	259	9	in	in	IN
cord-017585-0llgr357	259	10	the	the	DT
cord-017585-0llgr357	259	11	male	male	JJ
cord-017585-0llgr357	259	12	ACE2	ACE2	NNP
cord-017585-0llgr357	259	13	knockout	knockout	NN
cord-017585-0llgr357	259	14	mice	mouse	NNS
cord-017585-0llgr357	259	15	was	be	VBD
cord-017585-0llgr357	259	16	not	not	RB
cord-017585-0llgr357	259	17	evident	evident	JJ
cord-017585-0llgr357	259	18	in	in	IN
cord-017585-0llgr357	259	19	the	the	DT
cord-017585-0llgr357	259	20	estrogen	estrogen	NN
cord-017585-0llgr357	259	21	replete	replete	JJ
cord-017585-0llgr357	259	22	female	female	JJ
cord-017585-0llgr357	259	23	littermates	littermate	NNS
cord-017585-0llgr357	259	24	and	and	CC
cord-017585-0llgr357	259	25	possibly	possibly	RB
cord-017585-0llgr357	259	26	there	there	EX
cord-017585-0llgr357	259	27	is	be	VBZ
cord-017585-0llgr357	259	28	greater	great	JJR
cord-017585-0llgr357	259	29	expression	expression	NN
cord-017585-0llgr357	259	30	of	of	IN
cord-017585-0llgr357	259	31	RAAS	RAAS	NNP
cord-017585-0llgr357	259	32	components	component	NNS
cord-017585-0llgr357	259	33	in	in	IN
cord-017585-0llgr357	259	34	the	the	DT
cord-017585-0llgr357	259	35	males	male	NNS
cord-017585-0llgr357	259	36	with	with	IN
cord-017585-0llgr357	259	37	the	the	DT
cord-017585-0llgr357	259	38	loss	loss	NN
cord-017585-0llgr357	259	39	of	of	IN
cord-017585-0llgr357	259	40	ACE2	ACE2	NNP
cord-017585-0llgr357	259	41	(	(	-LRB-
cord-017585-0llgr357	259	42	Oudit	Oudit	NNP
cord-017585-0llgr357	259	43	et	et	NNP
cord-017585-0llgr357	259	44	al	al	NNP
cord-017585-0llgr357	259	45	2006	2006	CD
cord-017585-0llgr357	259	46	)	)	-RRB-
cord-017585-0llgr357	259	47	.	.	.
cord-017585-0llgr357	260	1	We	-PRON-	PRP
cord-017585-0llgr357	260	2	and	and	CC
cord-017585-0llgr357	260	3	others	other	NNS
cord-017585-0llgr357	260	4	have	have	VBP
cord-017585-0llgr357	260	5	shown	show	VBN
cord-017585-0llgr357	260	6	that	that	IN
cord-017585-0llgr357	260	7	estrogen	estrogen	NN
cord-017585-0llgr357	260	8	depletion	depletion	NN
cord-017585-0llgr357	260	9	is	be	VBZ
cord-017585-0llgr357	260	10	associated	associate	VBN
cord-017585-0llgr357	260	11	with	with	IN
cord-017585-0llgr357	260	12	altered	altered	JJ
cord-017585-0llgr357	260	13	expression	expression	NN
cord-017585-0llgr357	260	14	of	of	IN
cord-017585-0llgr357	260	15	renin	renin	NN
cord-017585-0llgr357	260	16	,	,	,
cord-017585-0llgr357	260	17	AT	at	IN
cord-017585-0llgr357	260	18	1	1	CD
cord-017585-0llgr357	260	19	receptors	receptor	NNS
cord-017585-0llgr357	260	20	,	,	,
cord-017585-0llgr357	260	21	ACE	ACE	NNP
cord-017585-0llgr357	260	22	and	and	CC
cord-017585-0llgr357	260	23	NOS	NOS	NNP
cord-017585-0llgr357	260	24	isoforms	isoform	NNS
cord-017585-0llgr357	260	25	,	,	,
cord-017585-0llgr357	260	26	as	as	RB
cord-017585-0llgr357	260	27	well	well	RB
cord-017585-0llgr357	260	28	as	as	IN
cord-017585-0llgr357	260	29	exacerbates	exacerbate	VBZ
cord-017585-0llgr357	260	30	hypertension	hypertension	NN
cord-017585-0llgr357	260	31	and	and	CC
cord-017585-0llgr357	260	32	salt	salt	NN
cord-017585-0llgr357	260	33	-	-	HYPH
cord-017585-0llgr357	260	34	sensitive	sensitive	JJ
cord-017585-0llgr357	260	35	renal	renal	JJ
cord-017585-0llgr357	260	36	injury	injury	NN
cord-017585-0llgr357	261	1	(	(	-LRB-
cord-017585-0llgr357	261	2	Bayorh	Bayorh	NNP
cord-017585-0llgr357	261	3	et	et	NNP
cord-017585-0llgr357	261	4	al	al	NNP
cord-017585-0llgr357	261	5	2001	2001	CD
cord-017585-0llgr357	261	6	;	;	:
cord-017585-0llgr357	261	7	Brosnihan	Brosnihan	NNP
cord-017585-0llgr357	261	8	et	et	NNP
cord-017585-0llgr357	261	9	al	al	NNP
cord-017585-0llgr357	261	10	1997	1997	CD
cord-017585-0llgr357	261	11	;	;	:
cord-017585-0llgr357	261	12	Chappell	Chappell	NNP
cord-017585-0llgr357	261	13	et	et	NNP
cord-017585-0llgr357	261	14	al	al	NNP
cord-017585-0llgr357	261	15	2003	2003	CD
cord-017585-0llgr357	261	16	;	;	:
cord-017585-0llgr357	261	17	Chappell	Chappell	NNP
cord-017585-0llgr357	261	18	et	et	NNP
cord-017585-0llgr357	261	19	al	al	NNP
cord-017585-0llgr357	261	20	2006	2006	CD
cord-017585-0llgr357	261	21	;	;	:
cord-017585-0llgr357	261	22	Harrison	Harrison	NNP
cord-017585-0llgr357	261	23	-	-	HYPH
cord-017585-0llgr357	261	24	Bernard	Bernard	NNP
cord-017585-0llgr357	261	25	et	et	NNP
cord-017585-0llgr357	261	26	al	al	NNP
cord-017585-0llgr357	261	27	2003	2003	CD
cord-017585-0llgr357	262	1	;	;	:
cord-017585-0llgr357	262	2	Roesch	Roesch	NNP
cord-017585-0llgr357	262	3	et	et	NNP
cord-017585-0llgr357	262	4	al	al	NNP
cord-017585-0llgr357	262	5	2000	2000	CD
cord-017585-0llgr357	262	6	;	;	:
cord-017585-0llgr357	263	1	Yamaleyeva	Yamaleyeva	NNP
cord-017585-0llgr357	263	2	et	et	NNP
cord-017585-0llgr357	263	3	al	al	NNP
cord-017585-0llgr357	263	4	2007	2007	CD
cord-017585-0llgr357	263	5	)	)	-RRB-
cord-017585-0llgr357	263	6	.	.	.
cord-017585-0llgr357	264	1	Moreover	moreover	RB
cord-017585-0llgr357	264	2	,	,	,
cord-017585-0llgr357	264	3	in	in	IN
cord-017585-0llgr357	264	4	lieu	lieu	NN
cord-017585-0llgr357	264	5	of	of	IN
cord-017585-0llgr357	264	6	the	the	DT
cord-017585-0llgr357	264	7	negative	negative	JJ
cord-017585-0llgr357	264	8	outcomes	outcome	NNS
cord-017585-0llgr357	264	9	for	for	IN
cord-017585-0llgr357	264	10	estrogen	estrogen	NN
cord-017585-0llgr357	264	11	or	or	CC
cord-017585-0llgr357	264	12	combined	combine	VBN
cord-017585-0llgr357	264	13	hormone	hormone	NN
cord-017585-0llgr357	264	14	replacement	replacement	NN
cord-017585-0llgr357	264	15	in	in	IN
cord-017585-0llgr357	264	16	older	old	JJR
cord-017585-0llgr357	264	17	women	woman	NNS
cord-017585-0llgr357	264	18	(	(	-LRB-
cord-017585-0llgr357	264	19	HERS	hers	RB
cord-017585-0llgr357	264	20	,	,	,
cord-017585-0llgr357	264	21	WHI	WHI	NNP
cord-017585-0llgr357	264	22	)	)	-RRB-
cord-017585-0llgr357	264	23	,	,	,
cord-017585-0llgr357	264	24	the	the	DT
cord-017585-0llgr357	264	25	influence	influence	NN
cord-017585-0llgr357	264	26	of	of	IN
cord-017585-0llgr357	264	27	aging	age	VBG
cord-017585-0llgr357	264	28	on	on	IN
cord-017585-0llgr357	264	29	the	the	DT
cord-017585-0llgr357	264	30	response	response	NN
cord-017585-0llgr357	264	31	of	of	IN
cord-017585-0llgr357	264	32	the	the	DT
cord-017585-0llgr357	264	33	intrarenal	intrarenal	JJ
cord-017585-0llgr357	264	34	RAAS	RAAS	NNP
cord-017585-0llgr357	264	35	and	and	CC
cord-017585-0llgr357	264	36	other	other	JJ
cord-017585-0llgr357	264	37	systems	system	NNS
cord-017585-0llgr357	264	38	may	may	MD
cord-017585-0llgr357	264	39	be	be	VB
cord-017585-0llgr357	264	40	of	of	IN
cord-017585-0llgr357	264	41	equal	equal	JJ
cord-017585-0llgr357	264	42	importance	importance	NN
cord-017585-0llgr357	264	43	.	.	.
cord-017585-0llgr357	265	1	Clearly	clearly	RB
cord-017585-0llgr357	265	2	,	,	,
cord-017585-0llgr357	265	3	understanding	understand	VBG
cord-017585-0llgr357	265	4	the	the	DT
cord-017585-0llgr357	265	5	regulation	regulation	NN
cord-017585-0llgr357	265	6	and	and	CC
cord-017585-0llgr357	265	7	interplay	interplay	NN
cord-017585-0llgr357	265	8	of	of	IN
cord-017585-0llgr357	265	9	ACE	ace	NN
cord-017585-0llgr357	265	10	,	,	,
cord-017585-0llgr357	265	11	ACE2	ACE2	NNP
cord-017585-0llgr357	265	12	and	and	CC
cord-017585-0llgr357	265	13	neprilysin	neprilysin	NNP
cord-017585-0llgr357	265	14	within	within	IN
cord-017585-0llgr357	265	15	the	the	DT
cord-017585-0llgr357	265	16	kidney	kidney	NN
cord-017585-0llgr357	265	17	,	,	,
cord-017585-0llgr357	265	18	as	as	RB
cord-017585-0llgr357	265	19	well	well	RB
cord-017585-0llgr357	265	20	as	as	IN
cord-017585-0llgr357	265	21	other	other	JJ
cord-017585-0llgr357	265	22	areas	area	NNS
cord-017585-0llgr357	265	23	including	include	VBG
cord-017585-0llgr357	265	24	the	the	DT
cord-017585-0llgr357	265	25	heart	heart	NN
cord-017585-0llgr357	265	26	,	,	,
cord-017585-0llgr357	265	27	brain	brain	NN
cord-017585-0llgr357	265	28	and	and	CC
cord-017585-0llgr357	265	29	vascular	vascular	JJ
cord-017585-0llgr357	265	30	beds	bed	NNS
cord-017585-0llgr357	265	31	are	be	VBP
cord-017585-0llgr357	265	32	critical	critical	JJ
cord-017585-0llgr357	265	33	to	to	IN
cord-017585-0llgr357	265	34	treating	treat	VBG
cord-017585-0llgr357	265	35	the	the	DT
cord-017585-0llgr357	265	36	burgeoning	burgeon	VBG
cord-017585-0llgr357	265	37	problem	problem	NN
cord-017585-0llgr357	265	38	of	of	IN
cord-017585-0llgr357	265	39	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	265	40	disease	disease	NN
cord-017585-0llgr357	265	41	.	.	.
cord-017585-0llgr357	266	1	-7	-7	LS
cord-017585-0llgr357	266	2	)	)	-RRB-
cord-017585-0llgr357	266	3	metabolism	metabolism	NN
cord-017585-0llgr357	266	4	in	in	IN
cord-017585-0llgr357	266	5	pulmonary	pulmonary	JJ
cord-017585-0llgr357	266	6	and	and	CC
cord-017585-0llgr357	266	7	renal	renal	JJ
cord-017585-0llgr357	266	8	tissues	tissue	NNS
cord-017585-0llgr357	266	9	High	high	JJ
cord-017585-0llgr357	266	10	plasma	plasma	NN
cord-017585-0llgr357	266	11	level	level	NN
cord-017585-0llgr357	266	12	of	of	IN
cord-017585-0llgr357	266	13	N	N	NNP
cord-017585-0llgr357	266	14	-	-	HYPH
cord-017585-0llgr357	266	15	Acetyl	Acetyl	NNP
cord-017585-0llgr357	266	16	-	-	HYPH
cord-017585-0llgr357	266	17	Seryl	Seryl	NNP
cord-017585-0llgr357	266	18	-	-	HYPH
cord-017585-0llgr357	266	19	Aspartyl	Aspartyl	NNP
cord-017585-0llgr357	266	20	-	-	HYPH
cord-017585-0llgr357	266	21	Lysyl	Lysyl	NNP
cord-017585-0llgr357	266	22	-	-	HYPH
cord-017585-0llgr357	266	23	Proline	Proline	NNP
cord-017585-0llgr357	266	24	:	:	:
cord-017585-0llgr357	266	25	A	a	DT
cord-017585-0llgr357	266	26	new	new	JJ
cord-017585-0llgr357	266	27	marker	marker	NN
cord-017585-0llgr357	266	28	of	of	IN
cord-017585-0llgr357	266	29	chronic	chronic	JJ
cord-017585-0llgr357	266	30	angiotensin	angiotensin	NN
cord-017585-0llgr357	266	31	-	-	HYPH
cord-017585-0llgr357	266	32	converting	convert	VBG
cord-017585-0llgr357	266	33	enzyme	enzyme	NN
cord-017585-0llgr357	266	34	inhibition	inhibition	NN
cord-017585-0llgr357	266	35	Sexual	sexual	JJ
cord-017585-0llgr357	266	36	dimorphism	dimorphism	NN
cord-017585-0llgr357	266	37	of	of	IN
cord-017585-0llgr357	266	38	blood	blood	NN
cord-017585-0llgr357	266	39	pressure	pressure	NN
cord-017585-0llgr357	266	40	:	:	:
cord-017585-0llgr357	266	41	Possible	possible	JJ
cord-017585-0llgr357	266	42	role	role	NN
cord-017585-0llgr357	266	43	of	of	IN
cord-017585-0llgr357	266	44	the	the	DT
cord-017585-0llgr357	266	45	renin	renin	NN
cord-017585-0llgr357	266	46	-	-	HYPH
cord-017585-0llgr357	266	47	angiotensin	angiotensin	NN
cord-017585-0llgr357	266	48	system	system	NN
cord-017585-0llgr357	266	49	Effects	effect	NNS
cord-017585-0llgr357	266	50	of	of	IN
cord-017585-0llgr357	266	51	enalapril	enalapril	NNP
cord-017585-0llgr357	266	52	,	,	,
cord-017585-0llgr357	266	53	tempol	tempol	NNP
cord-017585-0llgr357	266	54	,	,	,
cord-017585-0llgr357	266	55	and	and	CC
cord-017585-0llgr357	266	56	eplerenone	eplerenone	NN
cord-017585-0llgr357	266	57	on	on	IN
cord-017585-0llgr357	266	58	salt	salt	NN
cord-017585-0llgr357	266	59	-	-	HYPH
cord-017585-0llgr357	266	60	induced	induce	VBN
cord-017585-0llgr357	266	61	hypertension	hypertension	NN
cord-017585-0llgr357	266	62	in	in	IN
cord-017585-0llgr357	266	63	Dahl	Dahl	NNP
cord-017585-0llgr357	266	64	salt	salt	NN
cord-017585-0llgr357	266	65	-	-	HYPH
cord-017585-0llgr357	266	66	sensitive	sensitive	JJ
cord-017585-0llgr357	266	67	rats	rat	NNS
cord-017585-0llgr357	267	1	The	the	DT
cord-017585-0llgr357	267	2	role	role	NN
cord-017585-0llgr357	267	3	of	of	IN
cord-017585-0llgr357	267	4	gender	gender	NN
cord-017585-0llgr357	267	5	in	in	IN
cord-017585-0llgr357	267	6	salt	salt	NN
cord-017585-0llgr357	267	7	-	-	HYPH
cord-017585-0llgr357	267	8	induced	induce	VBN
cord-017585-0llgr357	267	9	hypertension	hypertension	NN
cord-017585-0llgr357	267	10	Proteolytic	Proteolytic	NNP
cord-017585-0llgr357	267	11	release	release	NN
cord-017585-0llgr357	267	12	of	of	IN
cord-017585-0llgr357	267	13	human	human	JJ
cord-017585-0llgr357	267	14	angiotensinconverting	angiotensinconverting	NN
cord-017585-0llgr357	267	15	enzyme	enzyme	NN
cord-017585-0llgr357	267	16	:	:	:
cord-017585-0llgr357	267	17	localization	localization	NN
cord-017585-0llgr357	267	18	of	of	IN
cord-017585-0llgr357	267	19	the	the	DT
cord-017585-0llgr357	267	20	cleavage	cleavage	NN
cord-017585-0llgr357	267	21	site	site	NN
cord-017585-0llgr357	267	22	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	267	23	-	-	HYPH
cord-017585-0llgr357	267	24	7	7	CD
cord-017585-0llgr357	267	25	)	)	-RRB-
cord-017585-0llgr357	267	26	prevents	prevent	VBZ
cord-017585-0llgr357	267	27	development	development	NN
cord-017585-0llgr357	267	28	of	of	IN
cord-017585-0llgr357	267	29	severe	severe	JJ
cord-017585-0llgr357	267	30	hypertension	hypertension	NN
cord-017585-0llgr357	267	31	and	and	CC
cord-017585-0llgr357	267	32	end	end	NN
cord-017585-0llgr357	267	33	-	-	HYPH
cord-017585-0llgr357	267	34	organ	organ	NN
cord-017585-0llgr357	267	35	damage	damage	NN
cord-017585-0llgr357	267	36	in	in	IN
cord-017585-0llgr357	267	37	spontaneously	spontaneously	RB
cord-017585-0llgr357	267	38	hypertensive	hypertensive	JJ
cord-017585-0llgr357	267	39	rats	rat	NNS
cord-017585-0llgr357	267	40	treated	treat	VBN
cord-017585-0llgr357	267	41	with	with	IN
cord-017585-0llgr357	267	42	L	L	NNP
cord-017585-0llgr357	267	43	-	-	HYPH
cord-017585-0llgr357	267	44	NAME	NAME	NNP
cord-017585-0llgr357	267	45	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	267	46	-	-	HYPH
cord-017585-0llgr357	267	47	7	7	CD
cord-017585-0llgr357	267	48	)	)	-RRB-
cord-017585-0llgr357	267	49	prevents	prevent	VBZ
cord-017585-0llgr357	267	50	diabetesinduced	diabetesinduced	JJ
cord-017585-0llgr357	267	51	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	267	52	dysfunction	dysfunction	NN
cord-017585-0llgr357	268	1	Angiotensin	angiotensin	NN
cord-017585-0llgr357	268	2	-	-	HYPH
cord-017585-0llgr357	268	3	converting	convert	VBG
cord-017585-0llgr357	268	4	enzyme	enzyme	NN
cord-017585-0llgr357	268	5	inhibitor	inhibitor	NN
cord-017585-0llgr357	268	6	ramiprilat	ramiprilat	NNP
cord-017585-0llgr357	268	7	interferes	interfere	VBZ
cord-017585-0llgr357	268	8	with	with	IN
cord-017585-0llgr357	268	9	the	the	DT
cord-017585-0llgr357	268	10	sequestration	sequestration	NN
cord-017585-0llgr357	268	11	of	of	IN
cord-017585-0llgr357	268	12	the	the	DT
cord-017585-0llgr357	268	13	B2	b2	NN
cord-017585-0llgr357	268	14	kinin	kinin	NNP
cord-017585-0llgr357	268	15	receptor	receptor	NN
cord-017585-0llgr357	268	16	within	within	IN
cord-017585-0llgr357	268	17	the	the	DT
cord-017585-0llgr357	268	18	plasma	plasma	NN
cord-017585-0llgr357	268	19	membrane	membrane	NN
cord-017585-0llgr357	268	20	of	of	IN
cord-017585-0llgr357	268	21	native	native	JJ
cord-017585-0llgr357	268	22	endothelial	endothelial	JJ
cord-017585-0llgr357	268	23	cells	cell	NNS
cord-017585-0llgr357	269	1	Estrogen	estrogen	NN
cord-017585-0llgr357	269	2	protects	protect	VBZ
cord-017585-0llgr357	269	3	transgenic	transgenic	JJ
cord-017585-0llgr357	269	4	hypertensive	hypertensive	JJ
cord-017585-0llgr357	269	5	rats	rat	NNS
cord-017585-0llgr357	269	6	by	by	IN
cord-017585-0llgr357	269	7	shifting	shift	VBG
cord-017585-0llgr357	269	8	the	the	DT
cord-017585-0llgr357	269	9	vasoconstrictor	vasoconstrictor	NN
cord-017585-0llgr357	269	10	-	-	HYPH
cord-017585-0llgr357	269	11	vasodilator	vasodilator	NN
cord-017585-0llgr357	269	12	balance	balance	NN
cord-017585-0llgr357	269	13	of	of	IN
cord-017585-0llgr357	269	14	RAS	RAS	NNP
cord-017585-0llgr357	269	15	Bi	Bi	NNP
cord-017585-0llgr357	269	16	-	-	HYPH
cord-017585-0llgr357	269	17	directional	directional	JJ
cord-017585-0llgr357	269	18	actions	action	NNS
cord-017585-0llgr357	269	19	of	of	IN
cord-017585-0llgr357	269	20	estrogen	estrogen	NN
cord-017585-0llgr357	269	21	on	on	IN
cord-017585-0llgr357	269	22	the	the	DT
cord-017585-0llgr357	269	23	renin	renin	NN
cord-017585-0llgr357	269	24	-	-	HYPH
cord-017585-0llgr357	269	25	angiotensin	angiotensin	NN
cord-017585-0llgr357	269	26	system	system	NN
cord-017585-0llgr357	269	27	.	.	.
cord-017585-0llgr357	270	1	Braz	Braz	NNP
cord-017585-0llgr357	270	2	Enhanced	Enhanced	NNP
cord-017585-0llgr357	270	3	renal	renal	JJ
cord-017585-0llgr357	270	4	immunocytochemical	immunocytochemical	JJ
cord-017585-0llgr357	270	5	expression	expression	NN
cord-017585-0llgr357	270	6	of	of	IN
cord-017585-0llgr357	270	7	ANG-(1	ANG-(1	NNP
cord-017585-0llgr357	270	8	-	-	SYM
cord-017585-0llgr357	270	9	7	7	CD
cord-017585-0llgr357	270	10	)	)	-RRB-
cord-017585-0llgr357	270	11	and	and	CC
cord-017585-0llgr357	270	12	ACE2	ACE2	NNP
cord-017585-0llgr357	270	13	during	during	IN
cord-017585-0llgr357	270	14	pregnancy	pregnancy	NN
cord-017585-0llgr357	270	15	Elevated	elevated	JJ
cord-017585-0llgr357	270	16	blood	blood	NN
cord-017585-0llgr357	270	17	pressure	pressure	NN
cord-017585-0llgr357	270	18	and	and	CC
cord-017585-0llgr357	270	19	heart	heart	NN
cord-017585-0llgr357	270	20	rate	rate	NN
cord-017585-0llgr357	270	21	in	in	IN
cord-017585-0llgr357	270	22	human	human	JJ
cord-017585-0llgr357	270	23	renin	renin	NN
cord-017585-0llgr357	270	24	receptor	receptor	NN
cord-017585-0llgr357	270	25	transgenic	transgenic	JJ
cord-017585-0llgr357	270	26	rats	rat	NNS
cord-017585-0llgr357	270	27	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	270	28	II	II	NNP
cord-017585-0llgr357	270	29	and	and	CC
cord-017585-0llgr357	270	30	its	-PRON-	PRP$
cord-017585-0llgr357	270	31	receptors	receptor	NNS
cord-017585-0llgr357	270	32	in	in	IN
cord-017585-0llgr357	270	33	the	the	DT
cord-017585-0llgr357	270	34	diabetic	diabetic	JJ
cord-017585-0llgr357	270	35	kidney	kidney	NN
cord-017585-0llgr357	270	36	Effect	effect	NN
cord-017585-0llgr357	270	37	of	of	IN
cord-017585-0llgr357	270	38	reduced	reduce	VBN
cord-017585-0llgr357	270	39	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	40	-	-	HYPH
cord-017585-0llgr357	270	41	converting	convert	VBG
cord-017585-0llgr357	270	42	enzyme	enzyme	NN
cord-017585-0llgr357	270	43	gene	gene	NN
cord-017585-0llgr357	270	44	expression	expression	NN
cord-017585-0llgr357	270	45	and	and	CC
cord-017585-0llgr357	270	46	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	47	-	-	HYPH
cord-017585-0llgr357	270	48	converting	convert	VBG
cord-017585-0llgr357	270	49	enzyme	enzyme	NN
cord-017585-0llgr357	270	50	inhibition	inhibition	NN
cord-017585-0llgr357	270	51	on	on	IN
cord-017585-0llgr357	270	52	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	53	and	and	CC
cord-017585-0llgr357	270	54	bradykinin	bradykinin	NN
cord-017585-0llgr357	270	55	peptide	peptide	NN
cord-017585-0llgr357	270	56	levels	level	NNS
cord-017585-0llgr357	270	57	in	in	IN
cord-017585-0llgr357	270	58	mice	mouse	NNS
cord-017585-0llgr357	270	59	Effects	effect	NNS
cord-017585-0llgr357	270	60	of	of	IN
cord-017585-0llgr357	270	61	neutral	neutral	JJ
cord-017585-0llgr357	270	62	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	270	63	inhibition	inhibition	NN
cord-017585-0llgr357	270	64	and	and	CC
cord-017585-0llgr357	270	65	combined	combine	VBN
cord-017585-0llgr357	270	66	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	67	converting	convert	VBG
cord-017585-0llgr357	270	68	enzyme	enzyme	NN
cord-017585-0llgr357	270	69	and	and	CC
cord-017585-0llgr357	270	70	neutral	neutral	JJ
cord-017585-0llgr357	270	71	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	270	72	inhibition	inhibition	NN
cord-017585-0llgr357	270	73	on	on	IN
cord-017585-0llgr357	270	74	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	75	and	and	CC
cord-017585-0llgr357	270	76	bradykinin	bradykinin	NN
cord-017585-0llgr357	270	77	peptides	peptide	NNS
cord-017585-0llgr357	270	78	in	in	IN
cord-017585-0llgr357	270	79	rats	rat	NNS
cord-017585-0llgr357	270	80	Differential	differential	JJ
cord-017585-0llgr357	270	81	regulation	regulation	NN
cord-017585-0llgr357	270	82	of	of	IN
cord-017585-0llgr357	270	83	angiotensin	angiotensin	NN
cord-017585-0llgr357	270	84	peptide	peptide	NN
cord-017585-0llgr357	270	85	levels	level	NNS
cord-017585-0llgr357	270	86	in	in	IN
cord-017585-0llgr357	270	87	plasma	plasma	NN
cord-017585-0llgr357	270	88	and	and	CC
cord-017585-0llgr357	270	89	kidney	kidney	NN
cord-017585-0llgr357	270	90	of	of	IN
cord-017585-0llgr357	270	91	the	the	DT
cord-017585-0llgr357	270	92	rat	rat	NN
cord-017585-0llgr357	270	93	Newly	newly	RB
cord-017585-0llgr357	270	94	recognized	recognize	VBD
cord-017585-0llgr357	270	95	components	component	NNS
cord-017585-0llgr357	270	96	of	of	IN
cord-017585-0llgr357	270	97	the	the	DT
cord-017585-0llgr357	270	98	Renin	Renin	NNP
cord-017585-0llgr357	270	99	-	-	HYPH
cord-017585-0llgr357	270	100	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	270	101	system	system	NN
cord-017585-0llgr357	270	102	:	:	:
cord-017585-0llgr357	270	103	potential	potential	JJ
cord-017585-0llgr357	270	104	roles	role	NNS
cord-017585-0llgr357	270	105	in	in	IN
cord-017585-0llgr357	270	106	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	270	107	and	and	CC
cord-017585-0llgr357	270	108	renal	renal	JJ
cord-017585-0llgr357	270	109	regulation	regulation	NN
cord-017585-0llgr357	271	1	Prolyl	Prolyl	NNP
cord-017585-0llgr357	271	2	oligopeptidase	oligopeptidase	NNP
cord-017585-0llgr357	271	3	is	be	VBZ
cord-017585-0llgr357	271	4	involved	involve	VBN
cord-017585-0llgr357	271	5	in	in	IN
cord-017585-0llgr357	271	6	release	release	NN
cord-017585-0llgr357	271	7	of	of	IN
cord-017585-0llgr357	271	8	the	the	DT
cord-017585-0llgr357	271	9	antifibrotic	antifibrotic	JJ
cord-017585-0llgr357	271	10	peptide	peptide	NNP
cord-017585-0llgr357	272	1	Ac	Ac	NNP
cord-017585-0llgr357	272	2	-	-	HYPH
cord-017585-0llgr357	272	3	SDKP	SDKP	NNP
cord-017585-0llgr357	272	4	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	272	5	-	-	HYPH
cord-017585-0llgr357	272	6	7	7	CD
cord-017585-0llgr357	272	7	)	)	-RRB-
cord-017585-0llgr357	272	8	is	be	VBZ
cord-017585-0llgr357	272	9	an	an	DT
cord-017585-0llgr357	272	10	endogenous	endogenous	JJ
cord-017585-0llgr357	272	11	peptide	peptide	NN
cord-017585-0llgr357	272	12	in	in	IN
cord-017585-0llgr357	272	13	the	the	DT
cord-017585-0llgr357	272	14	rat	rat	NN
cord-017585-0llgr357	272	15	brain	brain	NN
cord-017585-0llgr357	272	16	:	:	:
cord-017585-0llgr357	272	17	evidence	evidence	NN
cord-017585-0llgr357	272	18	for	for	IN
cord-017585-0llgr357	272	19	differential	differential	JJ
cord-017585-0llgr357	272	20	processing	processing	NN
cord-017585-0llgr357	272	21	of	of	IN
cord-017585-0llgr357	272	22	angiotensin	angiotensin	NN
cord-017585-0llgr357	272	23	peptides	peptide	NNS
cord-017585-0llgr357	272	24	Processing	Processing	NNP
cord-017585-0llgr357	272	25	of	of	IN
cord-017585-0llgr357	272	26	angiotensin	angiotensin	NN
cord-017585-0llgr357	272	27	peptides	peptide	NNS
cord-017585-0llgr357	272	28	by	by	IN
cord-017585-0llgr357	272	29	NG108	ng108	NN
cord-017585-0llgr357	272	30	-	-	HYPH
cord-017585-0llgr357	272	31	15	15	CD
cord-017585-0llgr357	272	32	neuroblastoma	neuroblastoma	NN
cord-017585-0llgr357	272	33	X	x	NN
cord-017585-0llgr357	272	34	glioma	glioma	NN
cord-017585-0llgr357	272	35	hybrid	hybrid	JJ
cord-017585-0llgr357	272	36	cell	cell	NN
cord-017585-0llgr357	272	37	line	line	NN
cord-017585-0llgr357	272	38	Metabolism	metabolism	NN
cord-017585-0llgr357	272	39	of	of	IN
cord-017585-0llgr357	272	40	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	272	41	-	-	SYM
cord-017585-0llgr357	272	42	7	7	CD
cord-017585-0llgr357	272	43	)	)	-RRB-
cord-017585-0llgr357	272	44	by	by	IN
cord-017585-0llgr357	272	45	angiotensin	angiotensin	NN
cord-017585-0llgr357	272	46	converting	convert	VBG
cord-017585-0llgr357	272	47	enzyme	enzyme	NN
cord-017585-0llgr357	272	48	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	272	49	-	-	HYPH
cord-017585-0llgr357	272	50	7	7	CD
cord-017585-0llgr357	272	51	)	)	-RRB-
cord-017585-0llgr357	272	52	in	in	IN
cord-017585-0llgr357	272	53	hypertension	hypertension	NN
cord-017585-0llgr357	272	54	Release	Release	NNP
cord-017585-0llgr357	272	55	of	of	IN
cord-017585-0llgr357	272	56	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	272	57	-	-	SYM
cord-017585-0llgr357	272	58	7	7	CD
cord-017585-0llgr357	272	59	)	)	-RRB-
cord-017585-0llgr357	272	60	from	from	IN
cord-017585-0llgr357	272	61	the	the	DT
cord-017585-0llgr357	272	62	rat	rat	NN
cord-017585-0llgr357	272	63	hindlimb	hindlimb	NN
cord-017585-0llgr357	272	64	:	:	:
cord-017585-0llgr357	272	65	influence	influence	NN
cord-017585-0llgr357	272	66	of	of	IN
cord-017585-0llgr357	272	67	angiotensin	angiotensin	NN
cord-017585-0llgr357	272	68	-	-	HYPH
cord-017585-0llgr357	272	69	converting	convert	VBG
cord-017585-0llgr357	272	70	enzyme	enzyme	NN
cord-017585-0llgr357	272	71	inhibition	inhibition	NN
cord-017585-0llgr357	272	72	Pathways	pathway	NNS
cord-017585-0llgr357	272	73	of	of	IN
cord-017585-0llgr357	272	74	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	272	75	-	-	SYM
cord-017585-0llgr357	272	76	7	7	CD
cord-017585-0llgr357	272	77	)	)	-RRB-
cord-017585-0llgr357	272	78	metabolism	metabolism	NN
cord-017585-0llgr357	272	79	in	in	IN
cord-017585-0llgr357	272	80	the	the	DT
cord-017585-0llgr357	272	81	kidney	kidney	NN
cord-017585-0llgr357	272	82	Omapatrilat	Omapatrilat	NNP
cord-017585-0llgr357	272	83	treatment	treatment	NN
cord-017585-0llgr357	272	84	is	be	VBZ
cord-017585-0llgr357	272	85	associated	associate	VBN
cord-017585-0llgr357	272	86	with	with	IN
cord-017585-0llgr357	272	87	increased	increase	VBN
cord-017585-0llgr357	272	88	ACE-2	ACE-2	NNP
cord-017585-0llgr357	272	89	and	and	CC
cord-017585-0llgr357	272	90	angiotensin-(1	angiotensin-(1	NN
cord-017585-0llgr357	272	91	-	-	SYM
cord-017585-0llgr357	272	92	7	7	CD
cord-017585-0llgr357	272	93	)	)	-RRB-
cord-017585-0llgr357	272	94	in	in	IN
cord-017585-0llgr357	273	1	spontaneously	spontaneously	RB
cord-017585-0llgr357	273	2	hypertensive	hypertensive	JJ
cord-017585-0llgr357	273	3	rats	rat	NNS
cord-017585-0llgr357	273	4	Estrogen	Estrogen	NNP
cord-017585-0llgr357	273	5	or	or	CC
cord-017585-0llgr357	273	6	the	the	DT
cord-017585-0llgr357	273	7	AT1	AT1	NNP
cord-017585-0llgr357	273	8	antagonist	antagonist	NN
cord-017585-0llgr357	273	9	olmesartan	olmesartan	NNP
cord-017585-0llgr357	273	10	reverses	reverse	VBZ
cord-017585-0llgr357	273	11	the	the	DT
cord-017585-0llgr357	273	12	development	development	NN
cord-017585-0llgr357	273	13	of	of	IN
cord-017585-0llgr357	273	14	profound	profound	JJ
cord-017585-0llgr357	273	15	hypertension	hypertension	NN
cord-017585-0llgr357	273	16	in	in	IN
cord-017585-0llgr357	273	17	the	the	DT
cord-017585-0llgr357	273	18	congenic	congenic	NNP
cord-017585-0llgr357	273	19	mRen2.Lewis	mren2.lewis	CD
cord-017585-0llgr357	273	20	rat	rat	NN
cord-017585-0llgr357	273	21	Novel	novel	JJ
cord-017585-0llgr357	273	22	aspects	aspect	NNS
cord-017585-0llgr357	273	23	of	of	IN
cord-017585-0llgr357	273	24	the	the	DT
cord-017585-0llgr357	273	25	renal	renal	JJ
cord-017585-0llgr357	273	26	renin	renin	NN
cord-017585-0llgr357	273	27	-	-	HYPH
cord-017585-0llgr357	273	28	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	29	system	system	NN
cord-017585-0llgr357	273	30	:	:	:
cord-017585-0llgr357	273	31	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	273	32	-	-	SYM
cord-017585-0llgr357	273	33	7	7	CD
cord-017585-0llgr357	273	34	)	)	-RRB-
cord-017585-0llgr357	273	35	,	,	,
cord-017585-0llgr357	273	36	ACE2	ACE2	NNP
cord-017585-0llgr357	273	37	and	and	CC
cord-017585-0llgr357	273	38	blood	blood	NN
cord-017585-0llgr357	273	39	pressure	pressure	NN
cord-017585-0llgr357	273	40	regulation	regulation	NN
cord-017585-0llgr357	273	41	Estrogen	estrogen	NN
cord-017585-0llgr357	273	42	and	and	CC
cord-017585-0llgr357	273	43	salt	salt	NN
cord-017585-0llgr357	273	44	sensitivity	sensitivity	NN
cord-017585-0llgr357	273	45	in	in	IN
cord-017585-0llgr357	273	46	the	the	DT
cord-017585-0llgr357	273	47	female	female	JJ
cord-017585-0llgr357	273	48	mRen(2).Lewis	mRen(2).Lewis	NNP
cord-017585-0llgr357	273	49	rat	rat	NN
cord-017585-0llgr357	273	50	Hydrolysis	hydrolysis	NN
cord-017585-0llgr357	273	51	of	of	IN
cord-017585-0llgr357	273	52	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	53	peptides	peptide	NNS
cord-017585-0llgr357	273	54	by	by	IN
cord-017585-0llgr357	273	55	human	human	JJ
cord-017585-0llgr357	273	56	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	57	I	I	NNP
cord-017585-0llgr357	273	58	-	-	HYPH
cord-017585-0llgr357	273	59	converting	convert	VBG
cord-017585-0llgr357	273	60	enzyme	enzyme	NN
cord-017585-0llgr357	273	61	and	and	CC
cord-017585-0llgr357	273	62	the	the	DT
cord-017585-0llgr357	273	63	resensitization	resensitization	NN
cord-017585-0llgr357	273	64	of	of	IN
cord-017585-0llgr357	273	65	B	B	NNP
cord-017585-0llgr357	273	66	2	2	CD
cord-017585-0llgr357	273	67	kinin	kinin	NNS
cord-017585-0llgr357	273	68	receptors	receptor	NNS
cord-017585-0llgr357	273	69	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	273	70	-	-	HYPH
cord-017585-0llgr357	273	71	7	7	NNP
cord-017585-0llgr357	273	72	)	)	-RRB-
cord-017585-0llgr357	273	73	downregulates	downregulate	VBZ
cord-017585-0llgr357	273	74	the	the	DT
cord-017585-0llgr357	273	75	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	76	II	II	NNP
cord-017585-0llgr357	273	77	type	type	NN
cord-017585-0llgr357	273	78	1	1	CD
cord-017585-0llgr357	273	79	receptor	receptor	NN
cord-017585-0llgr357	273	80	in	in	IN
cord-017585-0llgr357	273	81	vascular	vascular	JJ
cord-017585-0llgr357	273	82	smooth	smooth	JJ
cord-017585-0llgr357	273	83	muscle	muscle	NN
cord-017585-0llgr357	273	84	cells	cell	NNS
cord-017585-0llgr357	273	85	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	273	86	-	-	HYPH
cord-017585-0llgr357	273	87	7	7	CD
cord-017585-0llgr357	273	88	)	)	-RRB-
cord-017585-0llgr357	273	89	reduces	reduce	VBZ
cord-017585-0llgr357	273	90	renal	renal	JJ
cord-017585-0llgr357	273	91	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	92	II	II	NNP
cord-017585-0llgr357	273	93	receptors	receptor	NNS
cord-017585-0llgr357	273	94	through	through	IN
cord-017585-0llgr357	273	95	a	a	DT
cord-017585-0llgr357	273	96	cylocoxygenase	cylocoxygenase	JJ
cord-017585-0llgr357	273	97	dependent	dependent	JJ
cord-017585-0llgr357	273	98	pathway	pathway	NN
cord-017585-0llgr357	273	99	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	273	100	-	-	HYPH
cord-017585-0llgr357	273	101	converting	convert	VBG
cord-017585-0llgr357	273	102	enzyme	enzyme	NN
cord-017585-0llgr357	273	103	2	2	CD
cord-017585-0llgr357	273	104	is	be	VBZ
cord-017585-0llgr357	273	105	an	an	DT
cord-017585-0llgr357	273	106	essential	essential	JJ
cord-017585-0llgr357	273	107	regulator	regulator	NN
cord-017585-0llgr357	273	108	of	of	IN
cord-017585-0llgr357	273	109	heart	heart	NN
cord-017585-0llgr357	273	110	function	function	NN
cord-017585-0llgr357	273	111	N	n	CD
cord-017585-0llgr357	273	112	-	-	HYPH
cord-017585-0llgr357	273	113	domain	domain	NN
cord-017585-0llgr357	273	114	specific	specific	JJ
cord-017585-0llgr357	273	115	substrate	substrate	NN
cord-017585-0llgr357	273	116	and	and	CC
cord-017585-0llgr357	273	117	C	c	NN
cord-017585-0llgr357	273	118	-	-	HYPH
cord-017585-0llgr357	273	119	domain	domain	NN
cord-017585-0llgr357	273	120	inhibitors	inhibitor	NNS
cord-017585-0llgr357	273	121	of	of	IN
cord-017585-0llgr357	273	122	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	123	converting	convert	VBG
cord-017585-0llgr357	273	124	enzyme	enzyme	NN
cord-017585-0llgr357	273	125	ACE2	ACE2	NNP
cord-017585-0llgr357	273	126	gene	gene	NN
cord-017585-0llgr357	273	127	transfer	transfer	NN
cord-017585-0llgr357	273	128	attenuates	attenuate	VBZ
cord-017585-0llgr357	273	129	hypertension	hypertension	NN
cord-017585-0llgr357	273	130	-	-	HYPH
cord-017585-0llgr357	273	131	linked	link	VBN
cord-017585-0llgr357	273	132	pathophysiological	pathophysiological	JJ
cord-017585-0llgr357	273	133	changes	change	NNS
cord-017585-0llgr357	273	134	in	in	IN
cord-017585-0llgr357	273	135	the	the	DT
cord-017585-0llgr357	273	136	SHR	SHR	NNP
cord-017585-0llgr357	273	137	RXP	RXP	NNP
cord-017585-0llgr357	273	138	407	407	CD
cord-017585-0llgr357	273	139	,	,	,
cord-017585-0llgr357	273	140	a	a	DT
cord-017585-0llgr357	273	141	phosphinic	phosphinic	JJ
cord-017585-0llgr357	273	142	peptide	peptide	NN
cord-017585-0llgr357	273	143	,	,	,
cord-017585-0llgr357	273	144	is	be	VBZ
cord-017585-0llgr357	273	145	a	a	DT
cord-017585-0llgr357	273	146	potent	potent	JJ
cord-017585-0llgr357	273	147	inhibitor	inhibitor	NN
cord-017585-0llgr357	273	148	of	of	IN
cord-017585-0llgr357	273	149	angiotensin	angiotensin	NN
cord-017585-0llgr357	273	150	I	-PRON-	PRP
cord-017585-0llgr357	273	151	converting	convert	VBG
cord-017585-0llgr357	273	152	enzyme	enzyme	NN
cord-017585-0llgr357	273	153	able	able	JJ
cord-017585-0llgr357	273	154	to	to	TO
cord-017585-0llgr357	273	155	differentiate	differentiate	VB
cord-017585-0llgr357	273	156	between	between	IN
cord-017585-0llgr357	273	157	its	-PRON-	PRP$
cord-017585-0llgr357	273	158	two	two	CD
cord-017585-0llgr357	273	159	active	active	JJ
cord-017585-0llgr357	273	160	sites	site	NNS
cord-017585-0llgr357	274	1	A	a	DT
cord-017585-0llgr357	274	2	novel	novel	JJ
cord-017585-0llgr357	274	3	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	4	-	-	HYPH
cord-017585-0llgr357	274	5	converting	convert	VBG
cord-017585-0llgr357	274	6	enzymerelated	enzymerelated	JJ
cord-017585-0llgr357	274	7	carboxypeptidase	carboxypeptidase	NN
cord-017585-0llgr357	274	8	(	(	-LRB-
cord-017585-0llgr357	274	9	ACE2	ACE2	NNP
cord-017585-0llgr357	274	10	)	)	-RRB-
cord-017585-0llgr357	274	11	converts	convert	VBZ
cord-017585-0llgr357	274	12	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	13	I	-PRON-	PRP
cord-017585-0llgr357	274	14	to	to	IN
cord-017585-0llgr357	274	15	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	16	1	1	CD
cord-017585-0llgr357	274	17	-	-	SYM
cord-017585-0llgr357	274	18	9	9	CD
cord-017585-0llgr357	274	19	New	New	NNP
cord-017585-0llgr357	274	20	mass	mass	JJ
cord-017585-0llgr357	274	21	spectrometric	spectrometric	JJ
cord-017585-0llgr357	274	22	assay	assay	NN
cord-017585-0llgr357	274	23	for	for	IN
cord-017585-0llgr357	274	24	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	25	-	-	HYPH
cord-017585-0llgr357	274	26	converting	convert	VBG
cord-017585-0llgr357	274	27	enzyme	enzyme	NN
cord-017585-0llgr357	274	28	2	2	CD
cord-017585-0llgr357	274	29	activity	activity	NN
cord-017585-0llgr357	274	30	Potentiation	Potentiation	NNP
cord-017585-0llgr357	274	31	of	of	IN
cord-017585-0llgr357	274	32	bradykinin	bradykinin	NN
cord-017585-0llgr357	274	33	by	by	IN
cord-017585-0llgr357	274	34	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	274	35	-	-	SYM
cord-017585-0llgr357	274	36	7	7	CD
cord-017585-0llgr357	274	37	)	)	-RRB-
cord-017585-0llgr357	274	38	on	on	IN
cord-017585-0llgr357	274	39	arterioles	arteriole	NNS
cord-017585-0llgr357	274	40	of	of	IN
cord-017585-0llgr357	274	41	spontaneously	spontaneously	RB
cord-017585-0llgr357	274	42	hypertensive	hypertensive	JJ
cord-017585-0llgr357	274	43	rats	rat	NNS
cord-017585-0llgr357	274	44	studied	study	VBD
cord-017585-0llgr357	274	45	in	in	IN
cord-017585-0llgr357	274	46	vivo	vivo	NN
cord-017585-0llgr357	274	47	Characterization	characterization	NN
cord-017585-0llgr357	274	48	of	of	IN
cord-017585-0llgr357	274	49	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	274	50	-	-	SYM
cord-017585-0llgr357	274	51	7	7	CD
cord-017585-0llgr357	274	52	)	)	-RRB-
cord-017585-0llgr357	274	53	in	in	IN
cord-017585-0llgr357	274	54	the	the	DT
cord-017585-0llgr357	274	55	urine	urine	NN
cord-017585-0llgr357	274	56	of	of	IN
cord-017585-0llgr357	274	57	normal	normal	JJ
cord-017585-0llgr357	274	58	and	and	CC
cord-017585-0llgr357	274	59	essential	essential	JJ
cord-017585-0llgr357	274	60	hypertensive	hypertensive	JJ
cord-017585-0llgr357	274	61	subjects	subject	NNS
cord-017585-0llgr357	274	62	Effects	effect	NNS
cord-017585-0llgr357	274	63	of	of	IN
cord-017585-0llgr357	274	64	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	274	65	on	on	IN
cord-017585-0llgr357	274	66	the	the	DT
cord-017585-0llgr357	274	67	renin	renin	NN
cord-017585-0llgr357	274	68	angiotensin	angiotensin	NNP
cord-017585-0llgr357	274	69	system	system	NN
cord-017585-0llgr357	274	70	in	in	IN
cord-017585-0llgr357	274	71	salt	salt	NN
cord-017585-0llgr357	274	72	sensitive	sensitive	JJ
cord-017585-0llgr357	274	73	hypertension	hypertension	NN
cord-017585-0llgr357	274	74	Vasopeptidase	Vasopeptidase	NNP
cord-017585-0llgr357	274	75	inhibition	inhibition	NN
cord-017585-0llgr357	274	76	and	and	CC
cord-017585-0llgr357	274	77	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	274	78	-	-	SYM
cord-017585-0llgr357	274	79	7	7	CD
cord-017585-0llgr357	274	80	)	)	-RRB-
cord-017585-0llgr357	274	81	in	in	IN
cord-017585-0llgr357	274	82	the	the	DT
cord-017585-0llgr357	274	83	spontaneously	spontaneously	RB
cord-017585-0llgr357	274	84	hypertensive	hypertensive	JJ
cord-017585-0llgr357	274	85	rat	rat	NN
cord-017585-0llgr357	274	86	Effect	effect	NN
cord-017585-0llgr357	274	87	of	of	IN
cord-017585-0llgr357	274	88	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	89	converting	convert	VBG
cord-017585-0llgr357	274	90	enzyme	enzyme	NN
cord-017585-0llgr357	274	91	inhibition	inhibition	NN
cord-017585-0llgr357	274	92	and	and	CC
cord-017585-0llgr357	274	93	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	94	II	ii	CD
cord-017585-0llgr357	274	95	receptor	receptor	NN
cord-017585-0llgr357	274	96	blockers	blocker	NNS
cord-017585-0llgr357	274	97	on	on	IN
cord-017585-0llgr357	274	98	cardiac	cardiac	JJ
cord-017585-0llgr357	274	99	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	100	converting	convert	VBG
cord-017585-0llgr357	274	101	enzyme	enzyme	NN
cord-017585-0llgr357	274	102	2	2	CD
cord-017585-0llgr357	274	103	-7	-7	CD
cord-017585-0llgr357	274	104	)	)	-RRB-
cord-017585-0llgr357	274	105	forming	form	VBG
cord-017585-0llgr357	274	106	enzymes	enzyme	NNS
cord-017585-0llgr357	274	107	and	and	CC
cord-017585-0llgr357	274	108	receptors	receptor	NNS
cord-017585-0llgr357	274	109	Advances	advance	NNS
cord-017585-0llgr357	274	110	in	in	IN
cord-017585-0llgr357	274	111	biochemical	biochemical	JJ
cord-017585-0llgr357	274	112	and	and	CC
cord-017585-0llgr357	274	113	functional	functional	JJ
cord-017585-0llgr357	274	114	roles	role	NNS
cord-017585-0llgr357	274	115	of	of	IN
cord-017585-0llgr357	274	116	angiotensin	angiotensin	NN
cord-017585-0llgr357	274	117	converting	convert	VBG
cord-017585-0llgr357	274	118	enzyme	enzyme	NN
cord-017585-0llgr357	274	119	2	2	CD
cord-017585-0llgr357	274	120	and	and	CC
cord-017585-0llgr357	274	121	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	274	122	-	-	SYM
cord-017585-0llgr357	274	123	7	7	CD
cord-017585-0llgr357	274	124	)	)	-RRB-
cord-017585-0llgr357	274	125	in	in	IN
cord-017585-0llgr357	274	126	the	the	DT
cord-017585-0llgr357	274	127	regulation	regulation	NN
cord-017585-0llgr357	274	128	of	of	IN
cord-017585-0llgr357	274	129	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	274	130	function	function	NN
cord-017585-0llgr357	275	1	Distinct	distinct	JJ
cord-017585-0llgr357	275	2	roles	role	NNS
cord-017585-0llgr357	275	3	for	for	IN
cord-017585-0llgr357	275	4	Ang	Ang	NNP
cord-017585-0llgr357	275	5	II	II	NNP
cord-017585-0llgr357	275	6	and	and	CC
cord-017585-0llgr357	275	7	ANG-(1	ANG-(1	NNP
cord-017585-0llgr357	275	8	-	-	SYM
cord-017585-0llgr357	275	9	7	7	CD
cord-017585-0llgr357	275	10	)	)	-RRB-
cord-017585-0llgr357	275	11	in	in	IN
cord-017585-0llgr357	275	12	the	the	DT
cord-017585-0llgr357	275	13	regulation	regulation	NN
cord-017585-0llgr357	275	14	of	of	IN
cord-017585-0llgr357	275	15	angiotensin	angiotensin	NN
cord-017585-0llgr357	275	16	-	-	HYPH
cord-017585-0llgr357	275	17	converting	convert	VBG
cord-017585-0llgr357	275	18	enzyme	enzyme	NN
cord-017585-0llgr357	275	19	2	2	CD
cord-017585-0llgr357	275	20	in	in	IN
cord-017585-0llgr357	275	21	rat	rat	NN
cord-017585-0llgr357	275	22	astrocytes	astrocyte	NNS
cord-017585-0llgr357	275	23	Roles	role	NNS
cord-017585-0llgr357	275	24	of	of	IN
cord-017585-0llgr357	275	25	the	the	DT
cord-017585-0llgr357	275	26	two	two	CD
cord-017585-0llgr357	275	27	active	active	JJ
cord-017585-0llgr357	275	28	sites	site	NNS
cord-017585-0llgr357	275	29	of	of	IN
cord-017585-0llgr357	275	30	somatic	somatic	JJ
cord-017585-0llgr357	275	31	angiotensin	angiotensin	NN
cord-017585-0llgr357	275	32	-	-	HYPH
cord-017585-0llgr357	275	33	converting	convert	VBG
cord-017585-0llgr357	275	34	enzyme	enzyme	NN
cord-017585-0llgr357	275	35	in	in	IN
cord-017585-0llgr357	275	36	the	the	DT
cord-017585-0llgr357	275	37	cleavage	cleavage	NN
cord-017585-0llgr357	275	38	of	of	IN
cord-017585-0llgr357	275	39	angiotensin	angiotensin	NN
cord-017585-0llgr357	275	40	I	-PRON-	PRP
cord-017585-0llgr357	275	41	and	and	CC
cord-017585-0llgr357	275	42	bradykinin	bradykinin	NN
cord-017585-0llgr357	275	43	:	:	:
cord-017585-0llgr357	276	1	insights	insight	NNS
cord-017585-0llgr357	276	2	from	from	IN
cord-017585-0llgr357	276	3	selective	selective	JJ
cord-017585-0llgr357	276	4	inhibitors	inhibitor	NNS
cord-017585-0llgr357	277	1	Membrane	membrane	NN
cord-017585-0llgr357	277	2	-	-	HYPH
cord-017585-0llgr357	277	3	associated	associate	VBN
cord-017585-0llgr357	277	4	zinc	zinc	NN
cord-017585-0llgr357	277	5	peptidase	peptidase	NN
cord-017585-0llgr357	277	6	families	family	NNS
cord-017585-0llgr357	277	7	:	:	:
cord-017585-0llgr357	278	1	comparing	compare	VBG
cord-017585-0llgr357	278	2	ACE	ACE	NNP
cord-017585-0llgr357	278	3	and	and	CC
cord-017585-0llgr357	278	4	ACE2	ACE2	NNP
cord-017585-0llgr357	279	1	Quantitative	quantitative	JJ
cord-017585-0llgr357	279	2	mRNA	mRNA	NNP
cord-017585-0llgr357	279	3	expression	expression	NN
cord-017585-0llgr357	279	4	profiling	profiling	NN
cord-017585-0llgr357	279	5	of	of	IN
cord-017585-0llgr357	279	6	ACE	ace	NN
cord-017585-0llgr357	279	7	2	2	CD
cord-017585-0llgr357	279	8	,	,	,
cord-017585-0llgr357	279	9	a	a	DT
cord-017585-0llgr357	279	10	novel	novel	JJ
cord-017585-0llgr357	279	11	homologue	homologue	NN
cord-017585-0llgr357	279	12	of	of	IN
cord-017585-0llgr357	279	13	angiotensin	angiotensin	NN
cord-017585-0llgr357	279	14	converting	convert	VBG
cord-017585-0llgr357	279	15	enzyme	enzyme	NN
cord-017585-0llgr357	279	16	Potential	potential	JJ
cord-017585-0llgr357	279	17	mechanisms	mechanism	NNS
cord-017585-0llgr357	279	18	and	and	CC
cord-017585-0llgr357	279	19	physiologic	physiologic	JJ
cord-017585-0llgr357	279	20	actions	action	NNS
cord-017585-0llgr357	279	21	of	of	IN
cord-017585-0llgr357	279	22	intracellular	intracellular	JJ
cord-017585-0llgr357	279	23	angiotensin	angiotensin	NN
cord-017585-0llgr357	279	24	II	II	NNP
cord-017585-0llgr357	279	25	Intrarenal	Intrarenal	NNP
cord-017585-0llgr357	280	1	AT	at	IN
cord-017585-0llgr357	280	2	1	1	CD
cord-017585-0llgr357	280	3	receptor	receptor	NN
cord-017585-0llgr357	280	4	and	and	CC
cord-017585-0llgr357	280	5	ACE	ace	NN
cord-017585-0llgr357	280	6	binding	bind	VBG
cord-017585-0llgr357	280	7	in	in	IN
cord-017585-0llgr357	280	8	ANG	ANG	NNP
cord-017585-0llgr357	280	9	II	II	NNP
cord-017585-0llgr357	280	10	-	-	HYPH
cord-017585-0llgr357	280	11	induced	induce	VBN
cord-017585-0llgr357	280	12	hypertensive	hypertensive	JJ
cord-017585-0llgr357	280	13	rats	rat	NNS
cord-017585-0llgr357	280	14	Postovariectomy	Postovariectomy	NNP
cord-017585-0llgr357	280	15	hypertension	hypertension	NN
cord-017585-0llgr357	280	16	is	be	VBZ
cord-017585-0llgr357	280	17	linked	link	VBN
cord-017585-0llgr357	280	18	to	to	IN
cord-017585-0llgr357	280	19	increased	increase	VBN
cord-017585-0llgr357	280	20	renal	renal	JJ
cord-017585-0llgr357	280	21	AT1	at1	NN
cord-017585-0llgr357	280	22	receptor	receptor	NN
cord-017585-0llgr357	280	23	and	and	CC
cord-017585-0llgr357	280	24	salt	salt	NN
cord-017585-0llgr357	280	25	sensitivity	sensitivity	NN
cord-017585-0llgr357	280	26	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	280	27	I	I	NNP
cord-017585-0llgr357	280	28	-	-	HYPH
cord-017585-0llgr357	280	29	converting	convert	VBG
cord-017585-0llgr357	280	30	enzyme	enzyme	NN
cord-017585-0llgr357	280	31	isoforms	isoform	NNS
cord-017585-0llgr357	280	32	(	(	-LRB-
cord-017585-0llgr357	280	33	high	high	JJ
cord-017585-0llgr357	280	34	and	and	CC
cord-017585-0llgr357	280	35	low	low	JJ
cord-017585-0llgr357	280	36	molecular	molecular	JJ
cord-017585-0llgr357	280	37	weight	weight	NN
cord-017585-0llgr357	280	38	)	)	-RRB-
cord-017585-0llgr357	280	39	in	in	IN
cord-017585-0llgr357	280	40	urine	urine	NN
cord-017585-0llgr357	280	41	of	of	IN
cord-017585-0llgr357	280	42	premature	premature	JJ
cord-017585-0llgr357	280	43	and	and	CC
cord-017585-0llgr357	280	44	full	full	JJ
cord-017585-0llgr357	280	45	-	-	HYPH
cord-017585-0llgr357	280	46	term	term	NN
cord-017585-0llgr357	280	47	infants	infant	NNS
cord-017585-0llgr357	281	1	Renin	renin	NN
cord-017585-0llgr357	281	2	increases	increase	VBZ
cord-017585-0llgr357	281	3	mesangial	mesangial	JJ
cord-017585-0llgr357	281	4	cell	cell	NN
cord-017585-0llgr357	281	5	transforming	transform	VBG
cord-017585-0llgr357	281	6	growth	growth	NN
cord-017585-0llgr357	281	7	factor	factor	NN
cord-017585-0llgr357	281	8	-	-	HYPH
cord-017585-0llgr357	281	9	B1	b1	NN
cord-017585-0llgr357	281	10	matrix	matrix	NN
cord-017585-0llgr357	281	11	proteins	protein	NNS
cord-017585-0llgr357	281	12	through	through	IN
cord-017585-0llgr357	281	13	receptormediated	receptormediate	VBN
cord-017585-0llgr357	281	14	,	,	,
cord-017585-0llgr357	281	15	angiotensin	angiotensin	NN
cord-017585-0llgr357	281	16	II	II	NNP
cord-017585-0llgr357	281	17	-	-	HYPH
cord-017585-0llgr357	281	18	independent	independent	JJ
cord-017585-0llgr357	281	19	mechanisms	mechanism	NNS
cord-017585-0llgr357	282	1	Angiotensin	angiotensin	NN
cord-017585-0llgr357	282	2	II	II	NNP
cord-017585-0llgr357	282	3	AT1	AT1	NNP
cord-017585-0llgr357	282	4	receptors	receptor	NNS
cord-017585-0llgr357	282	5	regulate	regulate	VBP
cord-017585-0llgr357	282	6	ace2	ace2	NN
cord-017585-0llgr357	282	7	and	and	CC
cord-017585-0llgr357	282	8	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	282	9	-	-	SYM
cord-017585-0llgr357	282	10	7	7	CD
cord-017585-0llgr357	282	11	)	)	-RRB-
cord-017585-0llgr357	282	12	expression	expression	NN
cord-017585-0llgr357	282	13	in	in	IN
cord-017585-0llgr357	282	14	aorta	aorta	NN
cord-017585-0llgr357	282	15	of	of	IN
cord-017585-0llgr357	282	16	spontaneously	spontaneously	RB
cord-017585-0llgr357	282	17	hypertensive	hypertensive	JJ
cord-017585-0llgr357	282	18	rats	rat	NNS
cord-017585-0llgr357	283	1	Contribution	Contribution	NNP
cord-017585-0llgr357	283	2	of	of	IN
cord-017585-0llgr357	283	3	angiotensin	angiotensin	NN
cord-017585-0llgr357	283	4	II	ii	CD
cord-017585-0llgr357	283	5	internalization	internalization	NN
cord-017585-0llgr357	283	6	to	to	IN
cord-017585-0llgr357	283	7	intrarenal	intrarenal	NNP
cord-017585-0llgr357	283	8	angiotensin	angiotensin	NNP
cord-017585-0llgr357	283	9	II	II	NNP
cord-017585-0llgr357	283	10	levels	level	NNS
cord-017585-0llgr357	283	11	in	in	IN
cord-017585-0llgr357	283	12	rats	rat	NNS
cord-017585-0llgr357	283	13	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	283	14	-	-	HYPH
cord-017585-0llgr357	283	15	7	7	CD
cord-017585-0llgr357	283	16	)	)	-RRB-
cord-017585-0llgr357	283	17	contributes	contribute	VBZ
cord-017585-0llgr357	283	18	to	to	IN
cord-017585-0llgr357	283	19	the	the	DT
cord-017585-0llgr357	283	20	antihypertensive	antihypertensive	JJ
cord-017585-0llgr357	283	21	effects	effect	NNS
cord-017585-0llgr357	283	22	of	of	IN
cord-017585-0llgr357	283	23	blockade	blockade	NN
cord-017585-0llgr357	283	24	of	of	IN
cord-017585-0llgr357	283	25	the	the	DT
cord-017585-0llgr357	283	26	renin	renin	NN
cord-017585-0llgr357	283	27	-	-	HYPH
cord-017585-0llgr357	283	28	angiotensin	angiotensin	NN
cord-017585-0llgr357	283	29	system	system	NN
cord-017585-0llgr357	283	30	Evidence	evidence	NN
cord-017585-0llgr357	283	31	that	that	IN
cord-017585-0llgr357	283	32	prostaglandins	prostaglandin	NNS
cord-017585-0llgr357	283	33	mediate	mediate	VBP
cord-017585-0llgr357	283	34	the	the	DT
cord-017585-0llgr357	283	35	antihypertensive	antihypertensive	JJ
cord-017585-0llgr357	283	36	actions	action	NNS
cord-017585-0llgr357	283	37	of	of	IN
cord-017585-0llgr357	283	38	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	283	39	-	-	SYM
cord-017585-0llgr357	283	40	7	7	CD
cord-017585-0llgr357	283	41	)	)	-RRB-
cord-017585-0llgr357	283	42	during	during	IN
cord-017585-0llgr357	283	43	chronic	chronic	JJ
cord-017585-0llgr357	283	44	blockade	blockade	NN
cord-017585-0llgr357	283	45	of	of	IN
cord-017585-0llgr357	283	46	the	the	DT
cord-017585-0llgr357	283	47	renin	renin	NN
cord-017585-0llgr357	283	48	-	-	HYPH
cord-017585-0llgr357	283	49	angiotensin	angiotensin	NN
cord-017585-0llgr357	283	50	system	system	NN
cord-017585-0llgr357	283	51	Effect	Effect	NNP
cord-017585-0llgr357	283	52	of	of	IN
cord-017585-0llgr357	283	53	angiotensin	angiotensin	NN
cord-017585-0llgr357	283	54	II	ii	CD
cord-017585-0llgr357	283	55	blockade	blockade	NN
cord-017585-0llgr357	283	56	on	on	IN
cord-017585-0llgr357	283	57	a	a	DT
cord-017585-0llgr357	283	58	new	new	JJ
cord-017585-0llgr357	283	59	congenic	congenic	JJ
cord-017585-0llgr357	283	60	model	model	NN
cord-017585-0llgr357	283	61	of	of	IN
cord-017585-0llgr357	283	62	hypertension	hypertension	NN
cord-017585-0llgr357	283	63	derived	derive	VBN
cord-017585-0llgr357	283	64	from	from	IN
cord-017585-0llgr357	283	65	transgenic	transgenic	JJ
cord-017585-0llgr357	283	66	Ren-2	Ren-2	NNP
cord-017585-0llgr357	283	67	rats	rat	NNS
cord-017585-0llgr357	283	68	Mineralocorticoid	Mineralocorticoid	NNP
cord-017585-0llgr357	283	69	receptor	receptor	NN
cord-017585-0llgr357	283	70	blocker	blocker	NN
cord-017585-0llgr357	283	71	increases	increase	VBZ
cord-017585-0llgr357	284	1	angiotensin	angiotensin	NN
cord-017585-0llgr357	284	2	-	-	HYPH
cord-017585-0llgr357	284	3	converting	convert	VBG
cord-017585-0llgr357	284	4	enzyme	enzyme	NN
cord-017585-0llgr357	284	5	2	2	CD
cord-017585-0llgr357	284	6	activity	activity	NN
cord-017585-0llgr357	284	7	in	in	IN
cord-017585-0llgr357	284	8	congestive	congestive	JJ
cord-017585-0llgr357	284	9	heart	heart	NN
cord-017585-0llgr357	284	10	failure	failure	NN
cord-017585-0llgr357	284	11	patients	patient	NNS
cord-017585-0llgr357	284	12	ACE2	ACE2	NNP
cord-017585-0llgr357	284	13	activity	activity	NN
cord-017585-0llgr357	284	14	is	be	VBZ
cord-017585-0llgr357	284	15	increased	increase	VBN
cord-017585-0llgr357	284	16	in	in	IN
cord-017585-0llgr357	284	17	monocytederived	monocytederived	JJ
cord-017585-0llgr357	284	18	macrophages	macrophage	NNS
cord-017585-0llgr357	284	19	from	from	IN
cord-017585-0llgr357	284	20	prehypertensive	prehypertensive	JJ
cord-017585-0llgr357	284	21	subjects	subject	NNS
cord-017585-0llgr357	285	1	Aldosterone	Aldosterone	NNP
cord-017585-0llgr357	285	2	enhances	enhance	VBZ
cord-017585-0llgr357	285	3	renin	renin	NN
cord-017585-0llgr357	285	4	expression	expression	NN
cord-017585-0llgr357	285	5	in	in	IN
cord-017585-0llgr357	285	6	juxtaglomerular	juxtaglomerular	NNP
cord-017585-0llgr357	285	7	cells	cell	NNS
cord-017585-0llgr357	285	8	Expression	expression	NN
cord-017585-0llgr357	285	9	of	of	IN
cord-017585-0llgr357	285	10	angiotensinogen	angiotensinogen	NNP
cord-017585-0llgr357	285	11	mRNA	mRNA	NNP
cord-017585-0llgr357	285	12	and	and	CC
cord-017585-0llgr357	285	13	protein	protein	NN
cord-017585-0llgr357	285	14	in	in	IN
cord-017585-0llgr357	286	1	angiotensin	angiotensin	NNP
cord-017585-0llgr357	286	2	II	II	NNP
cord-017585-0llgr357	286	3	-	-	HYPH
cord-017585-0llgr357	286	4	dependent	dependent	JJ
cord-017585-0llgr357	286	5	hypertension	hypertension	NN
cord-017585-0llgr357	286	6	CK2	CK2	NNP
cord-017585-0llgr357	286	7	phosphorylates	phosphorylate	VBZ
cord-017585-0llgr357	286	8	the	the	DT
cord-017585-0llgr357	286	9	angiotensinconverting	angiotensinconverting	NN
cord-017585-0llgr357	286	10	enzyme	enzyme	NN
cord-017585-0llgr357	286	11	and	and	CC
cord-017585-0llgr357	286	12	regulates	regulate	VBZ
cord-017585-0llgr357	286	13	its	-PRON-	PRP$
cord-017585-0llgr357	286	14	retention	retention	NN
cord-017585-0llgr357	286	15	in	in	IN
cord-017585-0llgr357	286	16	the	the	DT
cord-017585-0llgr357	286	17	endothelial	endothelial	JJ
cord-017585-0llgr357	286	18	cell	cell	NN
cord-017585-0llgr357	286	19	plasma	plasma	NN
cord-017585-0llgr357	286	20	membrane	membrane	NN
cord-017585-0llgr357	286	21	Omapatrilat	Omapatrilat	NNP
cord-017585-0llgr357	286	22	and	and	CC
cord-017585-0llgr357	286	23	Enalapril	Enalapril	NNP
cord-017585-0llgr357	286	24	in	in	IN
cord-017585-0llgr357	286	25	Patients	Patients	NNP
cord-017585-0llgr357	286	26	With	with	IN
cord-017585-0llgr357	286	27	Hypertension	hypertension	NN
cord-017585-0llgr357	286	28	:	:	:
cord-017585-0llgr357	287	1	The	the	DT
cord-017585-0llgr357	287	2	Omapatrilat	Omapatrilat	NNP
cord-017585-0llgr357	287	3	Cardiovascular	Cardiovascular	NNP
cord-017585-0llgr357	287	4	Treatment	Treatment	NNP
cord-017585-0llgr357	287	5	vs.	vs.	FW
cord-017585-0llgr357	287	6	Enalapril	Enalapril	NNP
cord-017585-0llgr357	287	7	(	(	-LRB-
cord-017585-0llgr357	287	8	OCTAVE	octave	NN
cord-017585-0llgr357	287	9	)	)	-RRB-
cord-017585-0llgr357	288	1	Trial	trial	NN
cord-017585-0llgr357	288	2	Differential	differential	JJ
cord-017585-0llgr357	288	3	tissue	tissue	NN
cord-017585-0llgr357	288	4	and	and	CC
cord-017585-0llgr357	288	5	enzyme	enzyme	NN
cord-017585-0llgr357	288	6	inhibitory	inhibitory	JJ
cord-017585-0llgr357	288	7	effects	effect	NNS
cord-017585-0llgr357	288	8	of	of	IN
cord-017585-0llgr357	288	9	the	the	DT
cord-017585-0llgr357	288	10	vasopeptidase	vasopeptidase	NNP
cord-017585-0llgr357	288	11	inhibitor	inhibitor	NN
cord-017585-0llgr357	288	12	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	288	13	in	in	IN
cord-017585-0llgr357	288	14	the	the	DT
cord-017585-0llgr357	288	15	rat	rat	NN
cord-017585-0llgr357	288	16	Tumor	Tumor	NNP
cord-017585-0llgr357	288	17	necrosis	necrosis	NN
cord-017585-0llgr357	288	18	factor	factor	NN
cord-017585-0llgr357	288	19	-	-	:
cord-017585-0llgr357	288	20	a	a	DT
cord-017585-0llgr357	288	21	convertase	convertase	NN
cord-017585-0llgr357	288	22	(	(	-LRB-
cord-017585-0llgr357	288	23	ADAM17	adam17	NN
cord-017585-0llgr357	288	24	)	)	-RRB-
cord-017585-0llgr357	288	25	mediates	mediate	VBZ
cord-017585-0llgr357	288	26	regulated	regulate	VBN
cord-017585-0llgr357	288	27	ectodomain	ectodomain	NN
cord-017585-0llgr357	288	28	shedding	shedding	NN
cord-017585-0llgr357	288	29	of	of	IN
cord-017585-0llgr357	288	30	the	the	DT
cord-017585-0llgr357	288	31	severe	severe	JJ
cord-017585-0llgr357	288	32	-	-	HYPH
cord-017585-0llgr357	288	33	acute	acute	JJ
cord-017585-0llgr357	288	34	respiratory	respiratory	JJ
cord-017585-0llgr357	288	35	syndrome	syndrome	NN
cord-017585-0llgr357	288	36	-	-	HYPH
cord-017585-0llgr357	288	37	coronavirus	coronavirus	NN
cord-017585-0llgr357	288	38	(	(	-LRB-
cord-017585-0llgr357	288	39	SARS	SARS	NNP
cord-017585-0llgr357	288	40	-	-	HYPH
cord-017585-0llgr357	288	41	Co	Co	NNP
cord-017585-0llgr357	288	42	-	-	HYPH
cord-017585-0llgr357	288	43	V	v	NN
cord-017585-0llgr357	288	44	)	)	-RRB-
cord-017585-0llgr357	288	45	receptor	receptor	NN
cord-017585-0llgr357	288	46	,	,	,
cord-017585-0llgr357	288	47	angiotensin	angiotensin	NN
cord-017585-0llgr357	288	48	-	-	HYPH
cord-017585-0llgr357	288	49	converting	convert	VBG
cord-017585-0llgr357	288	50	enzyme-2	enzyme-2	NNP
cord-017585-0llgr357	289	1	(	(	-LRB-
cord-017585-0llgr357	289	2	ACE2	ACE2	NNP
cord-017585-0llgr357	289	3	)	)	-RRB-
cord-017585-0llgr357	290	1	The	the	DT
cord-017585-0llgr357	290	2	role	role	NN
cord-017585-0llgr357	290	3	of	of	IN
cord-017585-0llgr357	290	4	angiotensin	angiotensin	NN
cord-017585-0llgr357	290	5	converting	convert	VBG
cord-017585-0llgr357	290	6	enzyme	enzyme	NN
cord-017585-0llgr357	290	7	2	2	CD
cord-017585-0llgr357	290	8	in	in	IN
cord-017585-0llgr357	290	9	the	the	DT
cord-017585-0llgr357	290	10	generation	generation	NN
cord-017585-0llgr357	290	11	of	of	IN
cord-017585-0llgr357	290	12	angiotensin	angiotensin	NN
cord-017585-0llgr357	290	13	1	1	CD
cord-017585-0llgr357	290	14	-	-	SYM
cord-017585-0llgr357	290	15	7	7	CD
cord-017585-0llgr357	290	16	by	by	IN
cord-017585-0llgr357	290	17	rat	rat	NN
cord-017585-0llgr357	290	18	proximal	proximal	JJ
cord-017585-0llgr357	290	19	tubules	tubule	NNS
cord-017585-0llgr357	290	20	Functional	functional	JJ
cord-017585-0llgr357	290	21	expression	expression	NN
cord-017585-0llgr357	290	22	of	of	IN
cord-017585-0llgr357	290	23	the	the	DT
cord-017585-0llgr357	290	24	renin	renin	NN
cord-017585-0llgr357	290	25	-	-	HYPH
cord-017585-0llgr357	290	26	angiotensin	angiotensin	NN
cord-017585-0llgr357	290	27	system	system	NN
cord-017585-0llgr357	290	28	in	in	IN
cord-017585-0llgr357	290	29	human	human	JJ
cord-017585-0llgr357	290	30	podocytes	podocyte	NNS
cord-017585-0llgr357	290	31	Identification	identification	NN
cord-017585-0llgr357	290	32	and	and	CC
cord-017585-0llgr357	290	33	characterization	characterization	NN
cord-017585-0llgr357	290	34	of	of	IN
cord-017585-0llgr357	290	35	neutral	neutral	JJ
cord-017585-0llgr357	290	36	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	290	37	in	in	IN
cord-017585-0llgr357	290	38	endothelial	endothelial	JJ
cord-017585-0llgr357	290	39	cells	cell	NNS
cord-017585-0llgr357	290	40	from	from	IN
cord-017585-0llgr357	290	41	venous	venous	JJ
cord-017585-0llgr357	290	42	or	or	CC
cord-017585-0llgr357	290	43	arterial	arterial	JJ
cord-017585-0llgr357	290	44	origins	origin	NNS
cord-017585-0llgr357	290	45	N	n	CD
cord-017585-0llgr357	290	46	-	-	HYPH
cord-017585-0llgr357	290	47	domain	domain	NN
cord-017585-0llgr357	290	48	angiotensin	angiotensin	NN
cord-017585-0llgr357	290	49	-	-	HYPH
cord-017585-0llgr357	290	50	I	i	NN
cord-017585-0llgr357	290	51	-	-	HYPH
cord-017585-0llgr357	290	52	converting	convert	VBG
cord-017585-0llgr357	290	53	enzyme	enzyme	NN
cord-017585-0llgr357	290	54	with	with	IN
cord-017585-0llgr357	290	55	80	80	CD
cord-017585-0llgr357	290	56	kDa	kDa	NNS
cord-017585-0llgr357	290	57	as	as	IN
cord-017585-0llgr357	290	58	a	a	DT
cord-017585-0llgr357	290	59	possible	possible	JJ
cord-017585-0llgr357	290	60	genetic	genetic	JJ
cord-017585-0llgr357	290	61	marker	marker	NN
cord-017585-0llgr357	290	62	of	of	IN
cord-017585-0llgr357	290	63	hypertension	hypertension	NN
cord-017585-0llgr357	290	64	Depletion	depletion	NN
cord-017585-0llgr357	290	65	of	of	IN
cord-017585-0llgr357	290	66	tissue	tissue	NN
cord-017585-0llgr357	290	67	ace	ace	NN
cord-017585-0llgr357	290	68	differentially	differentially	RB
cord-017585-0llgr357	290	69	influences	influence	VBZ
cord-017585-0llgr357	290	70	the	the	DT
cord-017585-0llgr357	290	71	intrarenal	intrarenal	JJ
cord-017585-0llgr357	290	72	and	and	CC
cord-017585-0llgr357	290	73	urinary	urinary	JJ
cord-017585-0llgr357	290	74	expression	expression	NN
cord-017585-0llgr357	290	75	of	of	IN
cord-017585-0llgr357	290	76	angiotensins	angiotensin	NNS
cord-017585-0llgr357	290	77	Isolation	isolation	NN
cord-017585-0llgr357	290	78	and	and	CC
cord-017585-0llgr357	290	79	identification	identification	NN
cord-017585-0llgr357	290	80	of	of	IN
cord-017585-0llgr357	290	81	proangiotensin-12	proangiotensin-12	NNP
cord-017585-0llgr357	290	82	,	,	,
cord-017585-0llgr357	290	83	a	a	DT
cord-017585-0llgr357	290	84	possible	possible	JJ
cord-017585-0llgr357	290	85	component	component	NN
cord-017585-0llgr357	290	86	of	of	IN
cord-017585-0llgr357	290	87	the	the	DT
cord-017585-0llgr357	290	88	renin	renin	NN
cord-017585-0llgr357	290	89	-	-	HYPH
cord-017585-0llgr357	290	90	angiotensin	angiotensin	NN
cord-017585-0llgr357	290	91	system	system	NN
cord-017585-0llgr357	290	92	Regulation	regulation	NN
cord-017585-0llgr357	290	93	of	of	IN
cord-017585-0llgr357	290	94	intrarenal	intrarenal	NNP
cord-017585-0llgr357	290	95	angiotensin	angiotensin	NNP
cord-017585-0llgr357	290	96	II	II	NNP
cord-017585-0llgr357	290	97	in	in	IN
cord-017585-0llgr357	290	98	hypertension	hypertension	NN
cord-017585-0llgr357	291	1	Pivotal	pivotal	JJ
cord-017585-0llgr357	291	2	role	role	NN
cord-017585-0llgr357	291	3	of	of	IN
cord-017585-0llgr357	291	4	the	the	DT
cord-017585-0llgr357	291	5	renin	renin	NN
cord-017585-0llgr357	291	6	/	/	SYM
cord-017585-0llgr357	291	7	prorenin	prorenin	NN
cord-017585-0llgr357	291	8	receptor	receptor	NN
cord-017585-0llgr357	291	9	in	in	IN
cord-017585-0llgr357	291	10	angiotensin	angiotensin	NN
cord-017585-0llgr357	291	11	II	ii	CD
cord-017585-0llgr357	291	12	production	production	NN
cord-017585-0llgr357	291	13	and	and	CC
cord-017585-0llgr357	291	14	cellular	cellular	JJ
cord-017585-0llgr357	291	15	responses	response	NNS
cord-017585-0llgr357	291	16	to	to	IN
cord-017585-0llgr357	291	17	renin	renin	NN
cord-017585-0llgr357	291	18	N	N	NNP
cord-017585-0llgr357	291	19	-	-	HYPH
cord-017585-0llgr357	291	20	Acetyl	Acetyl	NNP
cord-017585-0llgr357	291	21	-	-	HYPH
cord-017585-0llgr357	291	22	Seryl	Seryl	NNP
cord-017585-0llgr357	291	23	-	-	HYPH
cord-017585-0llgr357	291	24	Aspartyl	Aspartyl	NNP
cord-017585-0llgr357	291	25	-	-	HYPH
cord-017585-0llgr357	291	26	Lysyl	Lysyl	NNP
cord-017585-0llgr357	291	27	-	-	HYPH
cord-017585-0llgr357	291	28	Proline	Proline	NNP
cord-017585-0llgr357	291	29	ameliorates	ameliorate	VBZ
cord-017585-0llgr357	291	30	the	the	DT
cord-017585-0llgr357	291	31	progression	progression	NN
cord-017585-0llgr357	291	32	of	of	IN
cord-017585-0llgr357	291	33	renal	renal	JJ
cord-017585-0llgr357	291	34	dysfunction	dysfunction	NN
cord-017585-0llgr357	291	35	and	and	CC
cord-017585-0llgr357	291	36	fibrosis	fibrosis	NN
cord-017585-0llgr357	291	37	and	and	CC
cord-017585-0llgr357	291	38	WKY	WKY	NNP
cord-017585-0llgr357	291	39	rats	rat	NNS
cord-017585-0llgr357	291	40	with	with	IN
cord-017585-0llgr357	291	41	established	establish	VBN
cord-017585-0llgr357	291	42	anti	anti	JJ
cord-017585-0llgr357	291	43	-	-	JJ
cord-017585-0llgr357	291	44	glomerular	glomerular	JJ
cord-017585-0llgr357	291	45	basement	basement	NN
cord-017585-0llgr357	291	46	membrane	membrane	NN
cord-017585-0llgr357	291	47	nephritis	nephritis	NN
cord-017585-0llgr357	291	48	Loss	loss	NN
cord-017585-0llgr357	291	49	of	of	IN
cord-017585-0llgr357	291	50	angiotensin	angiotensin	NN
cord-017585-0llgr357	291	51	-	-	HYPH
cord-017585-0llgr357	291	52	converting	convert	VBG
cord-017585-0llgr357	291	53	enzyme-2	enzyme-2	NNP
cord-017585-0llgr357	291	54	leads	lead	VBZ
cord-017585-0llgr357	291	55	to	to	IN
cord-017585-0llgr357	291	56	the	the	DT
cord-017585-0llgr357	291	57	late	late	JJ
cord-017585-0llgr357	291	58	development	development	NN
cord-017585-0llgr357	291	59	of	of	IN
cord-017585-0llgr357	291	60	angiotensin	angiotensin	NN
cord-017585-0llgr357	291	61	II	II	NNP
cord-017585-0llgr357	291	62	-	-	HYPH
cord-017585-0llgr357	291	63	dependent	dependent	JJ
cord-017585-0llgr357	291	64	glomerulosclerosis	glomerulosclerosis	NN
cord-017585-0llgr357	291	65	Comparison	comparison	NN
cord-017585-0llgr357	291	66	of	of	IN
cord-017585-0llgr357	291	67	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	291	68	and	and	CC
cord-017585-0llgr357	291	69	enalapril	enalapril	NN
cord-017585-0llgr357	291	70	in	in	IN
cord-017585-0llgr357	291	71	patients	patient	NNS
cord-017585-0llgr357	291	72	with	with	IN
cord-017585-0llgr357	291	73	chronic	chronic	JJ
cord-017585-0llgr357	291	74	heart	heart	NN
cord-017585-0llgr357	291	75	failure	failure	NN
cord-017585-0llgr357	291	76	.	.	.
cord-017585-0llgr357	292	1	The	the	DT
cord-017585-0llgr357	292	2	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	292	3	versus	versus	IN
cord-017585-0llgr357	292	4	enalapril	enalapril	NNP
cord-017585-0llgr357	292	5	randomized	randomize	VBD
cord-017585-0llgr357	292	6	trial	trial	NN
cord-017585-0llgr357	292	7	of	of	IN
cord-017585-0llgr357	292	8	utility	utility	NN
cord-017585-0llgr357	292	9	in	in	IN
cord-017585-0llgr357	292	10	reducing	reduce	VBG
cord-017585-0llgr357	292	11	events	event	NNS
cord-017585-0llgr357	292	12	(	(	-LRB-
cord-017585-0llgr357	292	13	OVERTURE	overture	NN
cord-017585-0llgr357	292	14	)	)	-RRB-
cord-017585-0llgr357	292	15	Physiology	physiology	NN
cord-017585-0llgr357	292	16	of	of	IN
cord-017585-0llgr357	292	17	local	local	JJ
cord-017585-0llgr357	292	18	renin	renin	NN
cord-017585-0llgr357	292	19	-	-	HYPH
cord-017585-0llgr357	292	20	angiotensin	angiotensin	NN
cord-017585-0llgr357	292	21	systems	system	NNS
cord-017585-0llgr357	292	22	Differential	differential	JJ
cord-017585-0llgr357	292	23	expression	expression	NN
cord-017585-0llgr357	292	24	of	of	IN
cord-017585-0llgr357	292	25	nuclear	nuclear	JJ
cord-017585-0llgr357	292	26	AT1	at1	NN
cord-017585-0llgr357	292	27	receptors	receptor	NNS
cord-017585-0llgr357	292	28	and	and	CC
cord-017585-0llgr357	292	29	angiotensin	angiotensin	NN
cord-017585-0llgr357	292	30	II	II	NNP
cord-017585-0llgr357	292	31	within	within	IN
cord-017585-0llgr357	292	32	the	the	DT
cord-017585-0llgr357	292	33	kidney	kidney	NN
cord-017585-0llgr357	292	34	of	of	IN
cord-017585-0llgr357	292	35	the	the	DT
cord-017585-0llgr357	292	36	male	male	JJ
cord-017585-0llgr357	292	37	congenic	congenic	NN
cord-017585-0llgr357	293	1	mRen2.Lewis	mren2.lewis	IN
cord-017585-0llgr357	293	2	rat	rat	NN
cord-017585-0llgr357	293	3	Ac	Ac	NNP
cord-017585-0llgr357	293	4	-	-	HYPH
cord-017585-0llgr357	293	5	SDKP	SDKP	NNP
cord-017585-0llgr357	293	6	reverses	reverse	VBZ
cord-017585-0llgr357	293	7	cardiac	cardiac	JJ
cord-017585-0llgr357	293	8	fibrosis	fibrosis	NN
cord-017585-0llgr357	293	9	in	in	IN
cord-017585-0llgr357	293	10	rats	rat	NNS
cord-017585-0llgr357	293	11	with	with	IN
cord-017585-0llgr357	293	12	renovascular	renovascular	JJ
cord-017585-0llgr357	293	13	hypertension	hypertension	NN
cord-017585-0llgr357	293	14	Enhancement	Enhancement	NNP
cord-017585-0llgr357	293	15	of	of	IN
cord-017585-0llgr357	293	16	collecting	collect	VBG
cord-017585-0llgr357	293	17	duct	duct	NN
cord-017585-0llgr357	293	18	renin	renin	NN
cord-017585-0llgr357	293	19	in	in	IN
cord-017585-0llgr357	293	20	angiotensin	angiotensin	NN
cord-017585-0llgr357	293	21	II	II	NNP
cord-017585-0llgr357	293	22	-	-	HYPH
cord-017585-0llgr357	293	23	dependent	dependent	JJ
cord-017585-0llgr357	293	24	hypertensive	hypertensive	JJ
cord-017585-0llgr357	293	25	rats	rat	NNS
cord-017585-0llgr357	294	1	The	the	DT
cord-017585-0llgr357	294	2	hemoregulatory	hemoregulatory	NN
cord-017585-0llgr357	294	3	peptide	peptide	NN
cord-017585-0llgr357	294	4	N	N	NNP
cord-017585-0llgr357	294	5	-	-	HYPH
cord-017585-0llgr357	294	6	acetyl	acetyl	NNP
cord-017585-0llgr357	294	7	-	-	HYPH
cord-017585-0llgr357	294	8	Ser	Ser	NNP
cord-017585-0llgr357	294	9	-	-	HYPH
cord-017585-0llgr357	294	10	Asp	Asp	NNP
cord-017585-0llgr357	294	11	-	-	HYPH
cord-017585-0llgr357	294	12	Lys	Lys	NNP
cord-017585-0llgr357	294	13	-	-	HYPH
cord-017585-0llgr357	294	14	Pro	Pro	NNP
cord-017585-0llgr357	294	15	is	be	VBZ
cord-017585-0llgr357	294	16	a	a	DT
cord-017585-0llgr357	294	17	natural	natural	JJ
cord-017585-0llgr357	294	18	and	and	CC
cord-017585-0llgr357	294	19	specific	specific	JJ
cord-017585-0llgr357	294	20	substrate	substrate	NN
cord-017585-0llgr357	294	21	of	of	IN
cord-017585-0llgr357	294	22	the	the	DT
cord-017585-0llgr357	294	23	N	n	CD
cord-017585-0llgr357	294	24	-	-	HYPH
cord-017585-0llgr357	294	25	terminal	terminal	JJ
cord-017585-0llgr357	294	26	active	active	JJ
cord-017585-0llgr357	294	27	site	site	NN
cord-017585-0llgr357	294	28	of	of	IN
cord-017585-0llgr357	294	29	human	human	JJ
cord-017585-0llgr357	294	30	angiotensin	angiotensin	NN
cord-017585-0llgr357	294	31	-	-	HYPH
cord-017585-0llgr357	294	32	converting	convert	VBG
cord-017585-0llgr357	294	33	enzyme	enzyme	NN
cord-017585-0llgr357	294	34	Gender	gender	NN
cord-017585-0llgr357	294	35	differences	difference	NNS
cord-017585-0llgr357	294	36	in	in	IN
cord-017585-0llgr357	294	37	development	development	NN
cord-017585-0llgr357	294	38	of	of	IN
cord-017585-0llgr357	294	39	hypertension	hypertension	NN
cord-017585-0llgr357	294	40	in	in	IN
cord-017585-0llgr357	294	41	spontaneously	spontaneously	RB
cord-017585-0llgr357	294	42	hypertensive	hypertensive	JJ
cord-017585-0llgr357	294	43	rats	rat	NNS
cord-017585-0llgr357	294	44	:	:	:
cord-017585-0llgr357	294	45	role	role	NN
cord-017585-0llgr357	294	46	of	of	IN
cord-017585-0llgr357	294	47	the	the	DT
cord-017585-0llgr357	294	48	renin	renin	NN
cord-017585-0llgr357	294	49	-	-	HYPH
cord-017585-0llgr357	294	50	angiotensin	angiotensin	NN
cord-017585-0llgr357	294	51	system	system	NN
cord-017585-0llgr357	295	1	Circulating	circulate	VBG
cord-017585-0llgr357	295	2	activities	activity	NNS
cord-017585-0llgr357	295	3	of	of	IN
cord-017585-0llgr357	295	4	angiotensin	angiotensin	NN
cord-017585-0llgr357	295	5	-	-	HYPH
cord-017585-0llgr357	295	6	converting	convert	VBG
cord-017585-0llgr357	295	7	enzyme	enzyme	NN
cord-017585-0llgr357	295	8	,	,	,
cord-017585-0llgr357	295	9	its	-PRON-	PRP$
cord-017585-0llgr357	295	10	homolog	homolog	NN
cord-017585-0llgr357	295	11	,	,	,
cord-017585-0llgr357	295	12	angiotensin	angiotensin	NN
cord-017585-0llgr357	295	13	-	-	HYPH
cord-017585-0llgr357	295	14	converting	convert	VBG
cord-017585-0llgr357	295	15	enzyme	enzyme	NN
cord-017585-0llgr357	295	16	2	2	CD
cord-017585-0llgr357	295	17	,	,	,
cord-017585-0llgr357	295	18	and	and	CC
cord-017585-0llgr357	295	19	neprilysin	neprilysin	NNP
cord-017585-0llgr357	295	20	in	in	IN
cord-017585-0llgr357	295	21	a	a	DT
cord-017585-0llgr357	295	22	family	family	NN
cord-017585-0llgr357	295	23	study	study	NN
cord-017585-0llgr357	295	24	Evaluation	Evaluation	NNP
cord-017585-0llgr357	295	25	of	of	IN
cord-017585-0llgr357	295	26	angiotensin	angiotensin	NN
cord-017585-0llgr357	295	27	-	-	HYPH
cord-017585-0llgr357	295	28	converting	convert	VBG
cord-017585-0llgr357	295	29	enzyme	enzyme	NN
cord-017585-0llgr357	295	30	(	(	-LRB-
cord-017585-0llgr357	295	31	ACE	ACE	NNP
cord-017585-0llgr357	295	32	)	)	-RRB-
cord-017585-0llgr357	295	33	,	,	,
cord-017585-0llgr357	295	34	its	-PRON-	PRP$
cord-017585-0llgr357	295	35	homologue	homologue	NN
cord-017585-0llgr357	295	36	ACE2	ACE2	NNP
cord-017585-0llgr357	295	37	and	and	CC
cord-017585-0llgr357	295	38	neprilysin	neprilysin	NNP
cord-017585-0llgr357	295	39	in	in	IN
cord-017585-0llgr357	295	40	angiotensin	angiotensin	NN
cord-017585-0llgr357	295	41	peptide	peptide	NN
cord-017585-0llgr357	295	42	metabolism	metabolism	NN
cord-017585-0llgr357	296	1	Estradiol	Estradiol	NNP
cord-017585-0llgr357	296	2	attenuates	attenuate	VBZ
cord-017585-0llgr357	296	3	angiotensininduced	angiotensininduced	JJ
cord-017585-0llgr357	296	4	aldosterone	aldosterone	NN
cord-017585-0llgr357	296	5	secretion	secretion	NN
cord-017585-0llgr357	296	6	in	in	IN
cord-017585-0llgr357	296	7	ovariectomized	ovariectomize	VBN
cord-017585-0llgr357	296	8	rats	rat	NNS
cord-017585-0llgr357	297	1	Angiotensin	angiotensin	NN
cord-017585-0llgr357	297	2	converting	convert	VBG
cord-017585-0llgr357	297	3	enzyme	enzyme	NN
cord-017585-0llgr357	297	4	-	-	HYPH
cord-017585-0llgr357	297	5	independent	independent	JJ
cord-017585-0llgr357	297	6	angiotensin	angiotensin	NN
cord-017585-0llgr357	297	7	II	ii	CD
cord-017585-0llgr357	297	8	production	production	NN
cord-017585-0llgr357	297	9	by	by	IN
cord-017585-0llgr357	297	10	chymase	chymase	NNP
cord-017585-0llgr357	297	11	is	be	VBZ
cord-017585-0llgr357	297	12	up	up	RB
cord-017585-0llgr357	297	13	-	-	HYPH
cord-017585-0llgr357	297	14	regulated	regulate	VBN
cord-017585-0llgr357	297	15	in	in	IN
cord-017585-0llgr357	297	16	the	the	DT
cord-017585-0llgr357	297	17	ischemic	ischemic	JJ
cord-017585-0llgr357	297	18	kidney	kidney	NN
cord-017585-0llgr357	297	19	in	in	IN
cord-017585-0llgr357	297	20	renovascular	renovascular	JJ
cord-017585-0llgr357	297	21	hypertension	hypertension	NN
cord-017585-0llgr357	298	1	Angiotensin	angiotensin	NN
cord-017585-0llgr357	298	2	II	II	NNP
cord-017585-0llgr357	298	3	exerts	exert	VBZ
cord-017585-0llgr357	298	4	positive	positive	JJ
cord-017585-0llgr357	298	5	feedback	feedback	NN
cord-017585-0llgr357	298	6	on	on	IN
cord-017585-0llgr357	298	7	the	the	DT
cord-017585-0llgr357	298	8	intrarenal	intrarenal	JJ
cord-017585-0llgr357	298	9	renin	renin	NN
cord-017585-0llgr357	298	10	-	-	HYPH
cord-017585-0llgr357	298	11	angiotensin	angiotensin	NN
cord-017585-0llgr357	298	12	system	system	NN
cord-017585-0llgr357	298	13	by	by	IN
cord-017585-0llgr357	298	14	an	an	DT
cord-017585-0llgr357	298	15	angiotensin	angiotensin	NN
cord-017585-0llgr357	298	16	converting	convert	VBG
cord-017585-0llgr357	298	17	enzyme	enzyme	NN
cord-017585-0llgr357	298	18	-	-	HYPH
cord-017585-0llgr357	298	19	dependent	dependent	JJ
cord-017585-0llgr357	298	20	mechanism	mechanism	NN
cord-017585-0llgr357	298	21	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	298	22	-	-	HYPH
cord-017585-0llgr357	298	23	7	7	CD
cord-017585-0llgr357	298	24	)	)	-RRB-
cord-017585-0llgr357	298	25	through	through	IN
cord-017585-0llgr357	299	1	receptor	receptor	NNP
cord-017585-0llgr357	299	2	mas	mas	NNP
cord-017585-0llgr357	299	3	mediates	mediate	VBZ
cord-017585-0llgr357	299	4	endothelial	endothelial	JJ
cord-017585-0llgr357	299	5	nitric	nitric	NN
cord-017585-0llgr357	299	6	oxide	oxide	NN
cord-017585-0llgr357	299	7	synthase	synthase	NN
cord-017585-0llgr357	299	8	activation	activation	NN
cord-017585-0llgr357	299	9	via	via	IN
cord-017585-0llgr357	299	10	Akt	Akt	NNP
cord-017585-0llgr357	299	11	-	-	HYPH
cord-017585-0llgr357	299	12	dependent	dependent	JJ
cord-017585-0llgr357	299	13	pathways	pathway	NNS
cord-017585-0llgr357	299	14	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	299	15	-	-	HYPH
cord-017585-0llgr357	299	16	7	7	CD
cord-017585-0llgr357	299	17	)	)	-RRB-
cord-017585-0llgr357	299	18	is	be	VBZ
cord-017585-0llgr357	299	19	an	an	DT
cord-017585-0llgr357	299	20	endogenous	endogenous	JJ
cord-017585-0llgr357	299	21	ligand	ligand	NN
cord-017585-0llgr357	299	22	for	for	IN
cord-017585-0llgr357	299	23	the	the	DT
cord-017585-0llgr357	299	24	G	G	NNP
cord-017585-0llgr357	299	25	protein	protein	NN
cord-017585-0llgr357	299	26	-	-	HYPH
cord-017585-0llgr357	299	27	coupled	couple	VBN
cord-017585-0llgr357	299	28	receptor	receptor	NN
cord-017585-0llgr357	299	29	Mas	Mas	NNP
cord-017585-0llgr357	299	30	Production	Production	NNP
cord-017585-0llgr357	299	31	of	of	IN
cord-017585-0llgr357	299	32	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	299	33	-	-	SYM
cord-017585-0llgr357	299	34	7	7	CD
cord-017585-0llgr357	299	35	)	)	-RRB-
cord-017585-0llgr357	299	36	by	by	IN
cord-017585-0llgr357	299	37	human	human	JJ
cord-017585-0llgr357	299	38	vascular	vascular	JJ
cord-017585-0llgr357	299	39	endothelium	endothelium	NN
cord-017585-0llgr357	299	40	Role	role	NN
cord-017585-0llgr357	299	41	of	of	IN
cord-017585-0llgr357	299	42	endothelin-1	endothelin-1	NNP
cord-017585-0llgr357	299	43	in	in	IN
cord-017585-0llgr357	299	44	hypertension	hypertension	NN
cord-017585-0llgr357	299	45	Effects	effect	NNS
cord-017585-0llgr357	299	46	of	of	IN
cord-017585-0llgr357	299	47	aldosterone	aldosterone	NN
cord-017585-0llgr357	299	48	on	on	IN
cord-017585-0llgr357	299	49	the	the	DT
cord-017585-0llgr357	299	50	vasculature	vasculature	NN
cord-017585-0llgr357	300	1	Renal	Renal	NNP
cord-017585-0llgr357	300	2	kallikrein	kallikrein	NNP
cord-017585-0llgr357	300	3	-	-	HYPH
cord-017585-0llgr357	300	4	kinin	kinin	NNP
cord-017585-0llgr357	300	5	system	system	NN
cord-017585-0llgr357	300	6	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	300	7	Metabolism	metabolism	NN
cord-017585-0llgr357	300	8	in	in	IN
cord-017585-0llgr357	300	9	Renal	Renal	NNP
cord-017585-0llgr357	300	10	Proximal	Proximal	NNP
cord-017585-0llgr357	300	11	Tubules	Tubules	NNP
cord-017585-0llgr357	300	12	,	,	,
cord-017585-0llgr357	300	13	Urine	urine	NN
cord-017585-0llgr357	300	14	and	and	CC
cord-017585-0llgr357	300	15	Serum	serum	NN
cord-017585-0llgr357	300	16	of	of	IN
cord-017585-0llgr357	300	17	Sheep	Sheep	NNP
cord-017585-0llgr357	300	18	:	:	:
cord-017585-0llgr357	300	19	Evidence	evidence	NN
cord-017585-0llgr357	300	20	for	for	IN
cord-017585-0llgr357	300	21	ACE2-Dependent	ACE2-Dependent	NNP
cord-017585-0llgr357	300	22	Processing	processing	NN
cord-017585-0llgr357	300	23	of	of	IN
cord-017585-0llgr357	301	1	Angiotensin	angiotensin	NN
cord-017585-0llgr357	301	2	II	II	NNP
cord-017585-0llgr357	301	3	A	a	DT
cord-017585-0llgr357	301	4	novel	novel	NN
cord-017585-0llgr357	301	5	mechanism	mechanism	NN
cord-017585-0llgr357	301	6	for	for	IN
cord-017585-0llgr357	301	7	angiotensin	angiotensin	NN
cord-017585-0llgr357	301	8	II	ii	CD
cord-017585-0llgr357	301	9	formation	formation	NN
cord-017585-0llgr357	301	10	in	in	IN
cord-017585-0llgr357	301	11	streptozoticindiabetic	streptozoticindiabetic	JJ
cord-017585-0llgr357	301	12	rat	rat	NN
cord-017585-0llgr357	301	13	glomeruli	glomeruli	NNP
cord-017585-0llgr357	301	14	Angiotensin	Angiotensin	NNP
cord-017585-0llgr357	301	15	converting	convert	VBG
cord-017585-0llgr357	301	16	enzyme	enzyme	NN
cord-017585-0llgr357	301	17	(	(	-LRB-
cord-017585-0llgr357	301	18	ACE	ACE	NNP
cord-017585-0llgr357	301	19	)	)	-RRB-
cord-017585-0llgr357	301	20	and	and	CC
cord-017585-0llgr357	301	21	neprilysin	neprilysin	NNP
cord-017585-0llgr357	301	22	hydrolyze	hydrolyze	VBP
cord-017585-0llgr357	301	23	neuropeptides	neuropeptide	NNS
cord-017585-0llgr357	301	24	:	:	:
cord-017585-0llgr357	301	25	a	a	DT
cord-017585-0llgr357	301	26	brief	brief	JJ
cord-017585-0llgr357	301	27	history	history	NN
cord-017585-0llgr357	301	28	,	,	,
cord-017585-0llgr357	301	29	the	the	DT
cord-017585-0llgr357	301	30	beginning	beginning	NN
cord-017585-0llgr357	301	31	and	and	CC
cord-017585-0llgr357	301	32	follow	follow	NN
cord-017585-0llgr357	301	33	-	-	HYPH
cord-017585-0llgr357	301	34	ups	up	NNS
cord-017585-0llgr357	301	35	to	to	IN
cord-017585-0llgr357	301	36	early	early	JJ
cord-017585-0llgr357	301	37	studies	study	NNS
cord-017585-0llgr357	302	1	Angiotensin-(1	angiotensin-(1	JJ
cord-017585-0llgr357	302	2	-	-	HYPH
cord-017585-0llgr357	302	3	7	7	CD
cord-017585-0llgr357	302	4	)	)	-RRB-
cord-017585-0llgr357	302	5	inhibits	inhibit	VBZ
cord-017585-0llgr357	302	6	angiotensin	angiotensin	NN
cord-017585-0llgr357	302	7	II	ii	NN
cord-017585-0llgr357	302	8	-	-	HYPH
cord-017585-0llgr357	302	9	stimulated	stimulate	VBN
cord-017585-0llgr357	302	10	phosphorylation	phosphorylation	NN
cord-017585-0llgr357	302	11	of	of	IN
cord-017585-0llgr357	302	12	MAP	MAP	NNP
cord-017585-0llgr357	302	13	kinases	kinase	NNS
cord-017585-0llgr357	302	14	in	in	IN
cord-017585-0llgr357	302	15	proximal	proximal	JJ
cord-017585-0llgr357	302	16	tubular	tubular	JJ
cord-017585-0llgr357	302	17	cells	cell	NNS
cord-017585-0llgr357	302	18	Mechanism	Mechanism	NNP
cord-017585-0llgr357	302	19	of	of	IN
cord-017585-0llgr357	302	20	vasopeptidase	vasopeptidase	NNP
cord-017585-0llgr357	302	21	inhibitor	inhibitor	NN
cord-017585-0llgr357	302	22	-	-	HYPH
cord-017585-0llgr357	302	23	induced	induce	VBN
cord-017585-0llgr357	302	24	plasma	plasma	NN
cord-017585-0llgr357	302	25	extravasation	extravasation	NN
cord-017585-0llgr357	302	26	:	:	:
cord-017585-0llgr357	303	1	Comparison	comparison	NN
cord-017585-0llgr357	303	2	of	of	IN
cord-017585-0llgr357	303	3	omapatrilat	omapatrilat	NNP
cord-017585-0llgr357	303	4	and	and	CC
cord-017585-0llgr357	303	5	the	the	DT
cord-017585-0llgr357	303	6	novel	novel	JJ
cord-017585-0llgr357	303	7	neutral	neutral	JJ
cord-017585-0llgr357	303	8	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	303	9	24.11	24.11	CD
cord-017585-0llgr357	303	10	/	/	SYM
cord-017585-0llgr357	303	11	angiotensin	angiotensin	NN
cord-017585-0llgr357	303	12	-	-	HYPH
cord-017585-0llgr357	303	13	converting	convert	VBG
cord-017585-0llgr357	303	14	enzyme	enzyme	NN
cord-017585-0llgr357	303	15	inhibitor	inhibitor	NN
cord-017585-0llgr357	303	16	GW796406	gw796406	CC
cord-017585-0llgr357	303	17	NF	NF	NNP
cord-017585-0llgr357	303	18	-	-	HYPH
cord-017585-0llgr357	303	19	kappaB	kappaB	NNP
cord-017585-0llgr357	303	20	-	-	HYPH
cord-017585-0llgr357	303	21	dependent	dependent	JJ
cord-017585-0llgr357	303	22	increase	increase	NN
cord-017585-0llgr357	303	23	in	in	IN
cord-017585-0llgr357	303	24	intrarenal	intrarenal	JJ
cord-017585-0llgr357	303	25	angiotensin	angiotensin	NNP
cord-017585-0llgr357	303	26	II	II	NNP
cord-017585-0llgr357	303	27	induced	induce	VBN
cord-017585-0llgr357	303	28	by	by	IN
cord-017585-0llgr357	303	29	proteinuria	proteinuria	NN
cord-017585-0llgr357	303	30	Angiotensin-(1	Angiotensin-(1	NNP
cord-017585-0llgr357	303	31	-	-	HYPH
cord-017585-0llgr357	303	32	7	7	CD
cord-017585-0llgr357	303	33	)	)	-RRB-
cord-017585-0llgr357	303	34	inhibits	inhibit	VBZ
cord-017585-0llgr357	303	35	growth	growth	NN
cord-017585-0llgr357	303	36	of	of	IN
cord-017585-0llgr357	303	37	cardiac	cardiac	JJ
cord-017585-0llgr357	303	38	myocytes	myocyte	NNS
cord-017585-0llgr357	303	39	through	through	IN
cord-017585-0llgr357	303	40	activation	activation	NN
cord-017585-0llgr357	303	41	of	of	IN
cord-017585-0llgr357	303	42	the	the	DT
cord-017585-0llgr357	303	43	mas	mas	NNP
cord-017585-0llgr357	303	44	receptor	receptor	NN
cord-017585-0llgr357	303	45	Differential	Differential	NNP
cord-017585-0llgr357	303	46	regulation	regulation	NN
cord-017585-0llgr357	303	47	of	of	IN
cord-017585-0llgr357	303	48	cardiac	cardiac	JJ
cord-017585-0llgr357	303	49	angiotensin	angiotensin	NN
cord-017585-0llgr357	303	50	converting	convert	VBG
cord-017585-0llgr357	303	51	enzyme	enzyme	NN
cord-017585-0llgr357	303	52	2	2	CD
cord-017585-0llgr357	303	53	(	(	-LRB-
cord-017585-0llgr357	303	54	ACE2	ACE2	NNP
cord-017585-0llgr357	303	55	)	)	-RRB-
cord-017585-0llgr357	303	56	and	and	CC
cord-017585-0llgr357	303	57	ACE	ace	NN
cord-017585-0llgr357	303	58	by	by	IN
cord-017585-0llgr357	303	59	aldosterone	aldosterone	NN
cord-017585-0llgr357	303	60	Characterization	characterization	NN
cord-017585-0llgr357	303	61	of	of	IN
cord-017585-0llgr357	303	62	renal	renal	JJ
cord-017585-0llgr357	303	63	Angiotensin	angiotensin	NN
cord-017585-0llgr357	303	64	-	-	HYPH
cord-017585-0llgr357	303	65	converting	convert	VBG
cord-017585-0llgr357	303	66	enzyme	enzyme	NN
cord-017585-0llgr357	303	67	2	2	CD
cord-017585-0llgr357	303	68	in	in	IN
cord-017585-0llgr357	303	69	diabetic	diabetic	JJ
cord-017585-0llgr357	303	70	nephropathy	nephropathy	NN
cord-017585-0llgr357	303	71	Developmental	developmental	JJ
cord-017585-0llgr357	303	72	expression	expression	NN
cord-017585-0llgr357	303	73	of	of	IN
cord-017585-0llgr357	303	74	ACE2	ACE2	NNP
cord-017585-0llgr357	303	75	in	in	IN
cord-017585-0llgr357	303	76	the	the	DT
cord-017585-0llgr357	303	77	SHR	SHR	NNP
cord-017585-0llgr357	303	78	kidney	kidney	NN
cord-017585-0llgr357	303	79	:	:	:
cord-017585-0llgr357	303	80	A	a	DT
cord-017585-0llgr357	303	81	role	role	NN
cord-017585-0llgr357	303	82	in	in	IN
cord-017585-0llgr357	303	83	hypertension	hypertension	NN
cord-017585-0llgr357	303	84	?	?	.
cord-017585-0llgr357	304	1	Combined	combined	JJ
cord-017585-0llgr357	304	2	inhibition	inhibition	NN
cord-017585-0llgr357	304	3	of	of	IN
cord-017585-0llgr357	304	4	neutral	neutral	JJ
cord-017585-0llgr357	304	5	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	304	6	with	with	IN
cord-017585-0llgr357	304	7	angiotensin	angiotensin	NN
cord-017585-0llgr357	304	8	converting	convert	VBG
cord-017585-0llgr357	304	9	enzyme	enzyme	NN
cord-017585-0llgr357	304	10	or	or	CC
cord-017585-0llgr357	304	11	endothelin	endothelin	NN
cord-017585-0llgr357	304	12	converting	converting	NN
cord-017585-0llgr357	304	13	enzyme	enzyme	NN
cord-017585-0llgr357	304	14	in	in	IN
cord-017585-0llgr357	304	15	experimental	experimental	JJ
cord-017585-0llgr357	304	16	diabetes	diabete	NNS
cord-017585-0llgr357	305	1	A	a	DT
cord-017585-0llgr357	305	2	human	human	JJ
cord-017585-0llgr357	305	3	homolog	homolog	NN
cord-017585-0llgr357	305	4	of	of	IN
cord-017585-0llgr357	305	5	angiotensin	angiotensin	NN
cord-017585-0llgr357	305	6	-	-	HYPH
cord-017585-0llgr357	305	7	converting	convert	VBG
cord-017585-0llgr357	305	8	enzyme	enzyme	NN
cord-017585-0llgr357	305	9	.	.	.
cord-017585-0llgr357	306	1	Cloning	clone	VBG
cord-017585-0llgr357	306	2	and	and	CC
cord-017585-0llgr357	306	3	functional	functional	JJ
cord-017585-0llgr357	306	4	expression	expression	NN
cord-017585-0llgr357	306	5	as	as	IN
cord-017585-0llgr357	306	6	a	a	DT
cord-017585-0llgr357	306	7	captopril	captopril	NN
cord-017585-0llgr357	306	8	-	-	HYPH
cord-017585-0llgr357	306	9	insensitive	insensitive	JJ
cord-017585-0llgr357	306	10	carboxypeptidase	carboxypeptidase	NN
cord-017585-0llgr357	306	11	Differential	differential	JJ
cord-017585-0llgr357	306	12	regulation	regulation	NN
cord-017585-0llgr357	306	13	of	of	IN
cord-017585-0llgr357	306	14	elevated	elevated	JJ
cord-017585-0llgr357	306	15	renal	renal	JJ
cord-017585-0llgr357	306	16	angiotensin	angiotensin	NN
cord-017585-0llgr357	306	17	II	II	NNP
cord-017585-0llgr357	306	18	in	in	IN
cord-017585-0llgr357	306	19	chronic	chronic	JJ
cord-017585-0llgr357	306	20	renal	renal	JJ
cord-017585-0llgr357	306	21	ischemia	ischemia	NN
cord-017585-0llgr357	306	22	Neutral	neutral	JJ
cord-017585-0llgr357	306	23	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	306	24	inhibition	inhibition	NN
cord-017585-0llgr357	306	25	:	:	:
cord-017585-0llgr357	306	26	the	the	DT
cord-017585-0llgr357	306	27	potential	potential	NN
cord-017585-0llgr357	306	28	of	of	IN
cord-017585-0llgr357	306	29	the	the	DT
cord-017585-0llgr357	306	30	new	new	JJ
cord-017585-0llgr357	306	31	therapeutic	therapeutic	JJ
cord-017585-0llgr357	306	32	approach	approach	NN
cord-017585-0llgr357	306	33	in	in	IN
cord-017585-0llgr357	306	34	cardiovascular	cardiovascular	JJ
cord-017585-0llgr357	306	35	disease	disease	NN
cord-017585-0llgr357	306	36	evolves	evolve	VBZ
cord-017585-0llgr357	306	37	Hydrolysis	hydrolysis	NN
cord-017585-0llgr357	306	38	of	of	IN
cord-017585-0llgr357	306	39	biological	biological	JJ
cord-017585-0llgr357	306	40	peptides	peptide	NNS
cord-017585-0llgr357	306	41	by	by	IN
cord-017585-0llgr357	306	42	human	human	JJ
cord-017585-0llgr357	306	43	angiotensin	angiotensin	NN
cord-017585-0llgr357	306	44	-	-	HYPH
cord-017585-0llgr357	306	45	converting	convert	VBG
cord-017585-0llgr357	306	46	enzyme	enzyme	NN
cord-017585-0llgr357	306	47	-	-	HYPH
cord-017585-0llgr357	306	48	related	relate	VBN
cord-017585-0llgr357	306	49	carboxypeptidase	carboxypeptidase	NN
cord-017585-0llgr357	306	50	A	a	DT
cord-017585-0llgr357	306	51	comparison	comparison	NN
cord-017585-0llgr357	306	52	of	of	IN
cord-017585-0llgr357	306	53	the	the	DT
cord-017585-0llgr357	306	54	properties	property	NNS
cord-017585-0llgr357	306	55	,	,	,
cord-017585-0llgr357	306	56	and	and	CC
cord-017585-0llgr357	306	57	enzymatic	enzymatic	JJ
cord-017585-0llgr357	306	58	activity	activity	NN
cord-017585-0llgr357	306	59	of	of	IN
cord-017585-0llgr357	306	60	three	three	CD
cord-017585-0llgr357	306	61	angiotensin	angiotensin	NN
cord-017585-0llgr357	306	62	processing	processing	NN
cord-017585-0llgr357	306	63	enzymes	enzyme	NNS
cord-017585-0llgr357	306	64	:	:	:
cord-017585-0llgr357	306	65	angiotensin	angiotensin	NN
cord-017585-0llgr357	306	66	converting	convert	VBG
cord-017585-0llgr357	306	67	enzyme	enzyme	NN
cord-017585-0llgr357	306	68	,	,	,
cord-017585-0llgr357	306	69	prolyl	prolyl	JJ
cord-017585-0llgr357	306	70	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	306	71	and	and	CC
cord-017585-0llgr357	306	72	neutral	neutral	JJ
cord-017585-0llgr357	306	73	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	306	74	24.11	24.11	CD
cord-017585-0llgr357	306	75	Distinct	distinct	JJ
cord-017585-0llgr357	306	76	gender	gender	NN
cord-017585-0llgr357	306	77	differences	difference	NNS
cord-017585-0llgr357	306	78	in	in	IN
cord-017585-0llgr357	306	79	the	the	DT
cord-017585-0llgr357	306	80	ACE2-dependent	ACE2-dependent	NNP
cord-017585-0llgr357	306	81	metabolism	metabolism	NN
cord-017585-0llgr357	306	82	of	of	IN
cord-017585-0llgr357	306	83	angiotensin	angiotensin	NN
cord-017585-0llgr357	306	84	II	II	NNP
cord-017585-0llgr357	306	85	in	in	IN
cord-017585-0llgr357	306	86	the	the	DT
cord-017585-0llgr357	306	87	serum	serum	NN
cord-017585-0llgr357	306	88	of	of	IN
cord-017585-0llgr357	306	89	sheep	sheep	NNP
cord-017585-0llgr357	306	90	AVE	AVE	NNP
cord-017585-0llgr357	306	91	0991	0991	CD
cord-017585-0llgr357	306	92	,	,	,
cord-017585-0llgr357	306	93	a	a	DT
cord-017585-0llgr357	306	94	nonpeptide	nonpeptide	NN
cord-017585-0llgr357	306	95	mimic	mimic	NN
cord-017585-0llgr357	306	96	of	of	IN
cord-017585-0llgr357	306	97	the	the	DT
cord-017585-0llgr357	306	98	effects	effect	NNS
cord-017585-0llgr357	306	99	of	of	IN
cord-017585-0llgr357	306	100	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	306	101	-	-	SYM
cord-017585-0llgr357	306	102	7	7	CD
cord-017585-0llgr357	306	103	)	)	-RRB-
cord-017585-0llgr357	306	104	on	on	IN
cord-017585-0llgr357	306	105	the	the	DT
cord-017585-0llgr357	306	106	endothelium	endothelium	NN
cord-017585-0llgr357	306	107	ACE	ace	NN
cord-017585-0llgr357	306	108	and	and	CC
cord-017585-0llgr357	306	109	ACE2	ACE2	NNP
cord-017585-0llgr357	306	110	activity	activity	NN
cord-017585-0llgr357	306	111	in	in	IN
cord-017585-0llgr357	306	112	diabetic	diabetic	JJ
cord-017585-0llgr357	306	113	mice	mouse	NNS
cord-017585-0llgr357	306	114	Converting	convert	VBG
cord-017585-0llgr357	306	115	enzyme	enzyme	NN
cord-017585-0llgr357	306	116	determines	determine	VBZ
cord-017585-0llgr357	306	117	the	the	DT
cord-017585-0llgr357	306	118	plasma	plasma	NN
cord-017585-0llgr357	306	119	clearance	clearance	NN
cord-017585-0llgr357	306	120	of	of	IN
cord-017585-0llgr357	306	121	angiotensin-(1	angiotensin-(1	CD
cord-017585-0llgr357	306	122	-	-	SYM
cord-017585-0llgr357	306	123	7	7	CD
cord-017585-0llgr357	306	124	)	)	-RRB-
cord-017585-0llgr357	307	1	Differential	differential	JJ
cord-017585-0llgr357	307	2	response	response	NN
cord-017585-0llgr357	307	3	of	of	IN
cord-017585-0llgr357	307	4	angiotensin	angiotensin	NN
cord-017585-0llgr357	307	5	peptides	peptide	NNS
cord-017585-0llgr357	307	6	in	in	IN
cord-017585-0llgr357	307	7	the	the	DT
cord-017585-0llgr357	307	8	urine	urine	NN
cord-017585-0llgr357	307	9	of	of	IN
cord-017585-0llgr357	307	10	hypertensive	hypertensive	JJ
cord-017585-0llgr357	307	11	animals	animal	NNS
cord-017585-0llgr357	307	12	Discoordinate	discoordinate	JJ
cord-017585-0llgr357	307	13	regulation	regulation	NN
cord-017585-0llgr357	307	14	of	of	IN
cord-017585-0llgr357	307	15	renal	renal	JJ
cord-017585-0llgr357	307	16	nitric	nitric	NN
cord-017585-0llgr357	307	17	oxide	oxide	NN
cord-017585-0llgr357	307	18	synthase	synthase	NN
cord-017585-0llgr357	307	19	isoforms	isoform	NNS
cord-017585-0llgr357	307	20	in	in	IN
cord-017585-0llgr357	307	21	ovariectomized	ovariectomize	VBN
cord-017585-0llgr357	307	22	mREN2.Lewis	mren2.lewis	$
cord-017585-0llgr357	307	23	rats	rat	NNS
cord-017585-0llgr357	307	24	In	in	IN
cord-017585-0llgr357	307	25	vivo	vivo	NN
cord-017585-0llgr357	307	26	metabolism	metabolism	NN
cord-017585-0llgr357	307	27	of	of	IN
cord-017585-0llgr357	307	28	angiotensin	angiotensin	NN
cord-017585-0llgr357	308	1	I	-PRON-	PRP
cord-017585-0llgr357	308	2	by	by	IN
cord-017585-0llgr357	308	3	neutral	neutral	JJ
cord-017585-0llgr357	308	4	endopeptidase	endopeptidase	NN
cord-017585-0llgr357	308	5	(	(	-LRB-
cord-017585-0llgr357	308	6	EC	EC	NNP
cord-017585-0llgr357	308	7	3.4.24.11	3.4.24.11	CD
cord-017585-0llgr357	308	8	)	)	-RRB-
cord-017585-0llgr357	308	9	in	in	IN
cord-017585-0llgr357	308	10	spontaneously	spontaneously	RB
cord-017585-0llgr357	308	11	hypertensive	hypertensive	JJ
cord-017585-0llgr357	308	12	rats	rat	NNS
cord-017585-0llgr357	309	1	Glomerular	glomerular	JJ
cord-017585-0llgr357	309	2	localization	localization	NN
cord-017585-0llgr357	309	3	and	and	CC
cord-017585-0llgr357	309	4	expression	expression	NN
cord-017585-0llgr357	309	5	of	of	IN
cord-017585-0llgr357	309	6	angiotensin	angiotensin	NN
cord-017585-0llgr357	309	7	-	-	HYPH
cord-017585-0llgr357	309	8	converting	convert	VBG
cord-017585-0llgr357	309	9	enzyme	enzyme	NN
cord-017585-0llgr357	309	10	2	2	CD
cord-017585-0llgr357	309	11	and	and	CC
cord-017585-0llgr357	309	12	angiotensin	angiotensin	NN
cord-017585-0llgr357	309	13	-	-	HYPH
cord-017585-0llgr357	309	14	converting	convert	VBG
cord-017585-0llgr357	309	15	enzyme	enzyme	NN
cord-017585-0llgr357	309	16	:	:	:
cord-017585-0llgr357	310	1	Implications	implication	NNS
cord-017585-0llgr357	310	2	for	for	IN
cord-017585-0llgr357	310	3	albuminemia	albuminemia	NN
cord-017585-0llgr357	310	4	in	in	IN
cord-017585-0llgr357	310	5	diabetes	diabetes	NN
cord-017585-0llgr357	310	6	Essential	Essential	NNP
cord-017585-0llgr357	310	7	role(s	role(s	NNP
cord-017585-0llgr357	310	8	)	)	-RRB-
cord-017585-0llgr357	310	9	of	of	IN
cord-017585-0llgr357	310	10	the	the	DT
cord-017585-0llgr357	310	11	intrarenal	intrarenal	JJ
cord-017585-0llgr357	310	12	renin	renin	NN
cord-017585-0llgr357	310	13	-	-	HYPH
cord-017585-0llgr357	310	14	angiotensin	angiotensin	NN
cord-017585-0llgr357	310	15	system	system	NN
cord-017585-0llgr357	310	16	in	in	IN
cord-017585-0llgr357	310	17	transforming	transform	VBG
cord-017585-0llgr357	310	18	growth	growth	NN
cord-017585-0llgr357	310	19	factor	factor	NN
cord-017585-0llgr357	310	20	-	-	HYPH
cord-017585-0llgr357	310	21	beta1	beta1	NN
cord-017585-0llgr357	310	22	gene	gene	NN
cord-017585-0llgr357	310	23	expression	expression	NN
cord-017585-0llgr357	310	24	and	and	CC
cord-017585-0llgr357	310	25	induction	induction	NN
cord-017585-0llgr357	310	26	of	of	IN
cord-017585-0llgr357	310	27	hypertrophy	hypertrophy	NN
cord-017585-0llgr357	310	28	of	of	IN
cord-017585-0llgr357	310	29	rat	rat	NN
cord-017585-0llgr357	310	30	kidney	kidney	NN
cord-017585-0llgr357	310	31	proximal	proximal	VBG
cord-017585-0llgr357	310	32	tubular	tubular	JJ
cord-017585-0llgr357	310	33	cells	cell	NNS
cord-017585-0llgr357	310	34	in	in	IN
cord-017585-0llgr357	310	35	high	high	JJ
cord-017585-0llgr357	310	36	glucose	glucose	NN
cord-017585-0llgr357	310	37	Upregulation	Upregulation	NNP
cord-017585-0llgr357	310	38	of	of	IN
cord-017585-0llgr357	310	39	angiotensinconverting	angiotensinconverte	VBG
cord-017585-0llgr357	310	40	enzyme	enzyme	NN
cord-017585-0llgr357	310	41	2	2	CD
cord-017585-0llgr357	310	42	by	by	IN
cord-017585-0llgr357	310	43	all	all	RB
cord-017585-0llgr357	310	44	-	-	HYPH
cord-017585-0llgr357	310	45	trans	trans	NNP
cord-017585-0llgr357	310	46	retinoic	retinoic	JJ
cord-017585-0llgr357	310	47	acid	acid	NN
cord-017585-0llgr357	310	48	in	in	IN
cord-017585-0llgr357	310	49	spontaneously	spontaneously	RB
cord-017585-0llgr357	310	50	hypertensive	hypertensive	JJ
cord-017585-0llgr357	310	51	rats	rat	NNS
cord-017585-0llgr357	311	1	These	these	DT
cord-017585-0llgr357	311	2	studies	study	NNS
cord-017585-0llgr357	311	3	were	be	VBD
cord-017585-0llgr357	311	4	supported	support	VBN
cord-017585-0llgr357	311	5	in	in	IN
cord-017585-0llgr357	311	6	part	part	NN
cord-017585-0llgr357	311	7	by	by	IN
cord-017585-0llgr357	311	8	grants	grant	NNS
cord-017585-0llgr357	311	9	from	from	IN
cord-017585-0llgr357	311	10	the	the	DT
cord-017585-0llgr357	311	11	National	National	NNP
cord-017585-0llgr357	311	12	Institute	Institute	NNP
cord-017585-0llgr357	311	13	of	of	IN
cord-017585-0llgr357	311	14	Health	Health	NNP
cord-017585-0llgr357	311	15	grants	grant	NNS
cord-017585-0llgr357	311	16	(	(	-LRB-
cord-017585-0llgr357	311	17	HL-56973	hl-56973	RB
cord-017585-0llgr357	311	18	and	and	CC
cord-017585-0llgr357	311	19	HL-51952	HL-51952	NNP
cord-017585-0llgr357	311	20	)	)	-RRB-
cord-017585-0llgr357	311	21	and	and	CC
cord-017585-0llgr357	311	22	the	the	DT
cord-017585-0llgr357	311	23	American	American	NNP
cord-017585-0llgr357	311	24	Heart	Heart	NNP
cord-017585-0llgr357	311	25	Association	Association	NNP
cord-017585-0llgr357	311	26	(	(	-LRB-
cord-017585-0llgr357	311	27	AHA-151521	AHA-151521	NNP
cord-017585-0llgr357	311	28	and	and	CC
cord-017585-0llgr357	311	29	AHA-355741	AHA-355741	NNP
cord-017585-0llgr357	311	30	)	)	-RRB-
cord-017585-0llgr357	311	31	.	.	.
cord-017585-0llgr357	312	1	An	an	DT
cord-017585-0llgr357	312	2	unrestricted	unrestricted	JJ
cord-017585-0llgr357	312	3	grant	grant	NN
cord-017585-0llgr357	312	4	from	from	IN
cord-017585-0llgr357	312	5	the	the	DT
cord-017585-0llgr357	312	6	Unifi	Unifi	NNP
cord-017585-0llgr357	312	7	Corporation	Corporation	NNP
cord-017585-0llgr357	312	8	(	(	-LRB-
cord-017585-0llgr357	312	9	Greensboro	Greensboro	NNP
cord-017585-0llgr357	312	10	,	,	,
cord-017585-0llgr357	312	11	NC	NC	NNP
cord-017585-0llgr357	312	12	)	)	-RRB-
cord-017585-0llgr357	312	13	and	and	CC
cord-017585-0llgr357	312	14	the	the	DT
cord-017585-0llgr357	312	15	Farley	Farley	NNP
cord-017585-0llgr357	312	16	-	-	HYPH
cord-017585-0llgr357	312	17	Hudson	Hudson	NNP
cord-017585-0llgr357	312	18	Foundation	Foundation	NNP
cord-017585-0llgr357	312	19	(	(	-LRB-
cord-017585-0llgr357	312	20	Jacksonville	Jacksonville	NNP
cord-017585-0llgr357	312	21	,	,	,
cord-017585-0llgr357	312	22	NC	NC	NNP
cord-017585-0llgr357	312	23	)	)	-RRB-
cord-017585-0llgr357	312	24	is	be	VBZ
cord-017585-0llgr357	312	25	also	also	RB
cord-017585-0llgr357	312	26	acknowledged	acknowledge	VBN
cord-017585-0llgr357	312	27	.	.	.