id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326405-3446eyi3	Wysocki, Jan	Angiotensin-converting enzyme 2: Possible role in hypertension and kidney disease	2008-02-07		.txt	text/plain	5654	298	48	The high catalytic efficiency of ACE2 for the generation of angiotensin (ANG)-1-7 from ANG II suggests an important role of ACE2 in preventing ANG II accumulation, while at the same time enhancing ANG-1-7 formation. [41] , primarily describing an Ace2 knockout and its associated cardiac pathology, also reported that ACE2 was reduced at the gene and protein level in kidneys from three separate rat models of spontaneous and diet-induced hypertension. Investigating the role of ACE2 in those two prevalent diseases and whether its effects are mediated by ANG II or ANG-(1-7) and other biologically active peptides, which are also substrates of ACE2, opens the way for developing new therapeutic targets in hypertension. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice Also, pharmacologic ACE2 inhibition was associated with increased albuminuria, suggesting a role of glomerular ACE2 in diabetic kidney injury	./cache/cord-326405-3446eyi3.txt	./txt/cord-326405-3446eyi3.txt