id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318327-9sh2eksm	Garg, M.	Review article: the pathophysiological roles of the renin–angiotensin system in the gastrointestinal tract	2012-01-05		.txt	text/plain	7219	425	42	Animal studies investigating the effects of RAS blockade in a range of conditions including inflammatory bowel disease, functional gut disorders, gastrointestinal malignancy and even intestinal ischaemia have been encouraging to date. Animal studies investigating the effects of RAS blockade in a range of conditions including inflammatory bowel disease, functional gut disorders, gastrointestinal malignancy and even intestinal ischaemia have been encouraging to date. The contemporary view of the RAS has evolved from that of a simple linear pathway involving the conversion of angiotensinogen to angiotensin II (Ang II) via a two-step process facilitated by renin and angiotensin converting enzyme (ACE), to a much more complex system involving homologues of ACE and multiple angiotensin peptides which play supplementary and counter-regulatory roles ( Figure 1 ). Angiotensin converting enzyme inhibition or angiotensin receptor antagonism have been shown to produce a number of beneficial anti-inflammatory effects in rodent models of intestinal inflammation.	./cache/cord-318327-9sh2eksm.txt	./txt/cord-318327-9sh2eksm.txt