id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315754-dq2empne	Hasan, Anwarul	A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin	2020-04-22		.txt	text/plain	4662	272	50	Angiotensin-converting enzyme-2 (ACE-2) is one of the most important receptors on the cell membrane of the host cells (HCs) which its interaction with spike protein (SP) with a furin-cleavage site results in the SARS-CoV-2 invasion. Genomic analysis of the new CoV has shown that its SP differs from that of other viruses (Du et al., 2017; Li, 2016) , indicating that the protein has a site activated by a HC enzyme called furin (Millet & Whittaker, 2015) (Figure 1 ). The furin activation site (FAS) makes the new CoV much different in cell entry than SARS, and probably affects the stability of the virus and, consequently, the transmission process (Li et al., 2015; Millet & Whittaker, 2014; Yamada & Liu, 2009) . A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2	./cache/cord-315754-dq2empne.txt	./txt/cord-315754-dq2empne.txt