id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314868-ei2b8oqn	Leung, J. M.	ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19	2020-03-23		.txt	text/plain	2712	190	58	Because individuals with chronic obstructive pulmonary disease (COPD) are at increased risk of severe COVID19, we determined whether ACE2 expression in the lower airways was related to COPD and cigarette smoking. Results: In the discovery cohort (n=42 participants), we found that ACE2 expression levels were increased by 48% in the airways of COPD compared with non-COPD subjects (COPD=2.52 (0.66) log2 counts per million reads (CPM) versus non-COPD= 1.70 (0.51) CPM , p=.000762). In summary, active cigarette smoking and COPD up-regulate ACE-2 expression in lower airways, which in part may explain the increased risk of severe COVID-19 in these sub-populations. The P-value was obtained from the robust linear model Abbreviations: ACE-2, angiotensin converting enzyme II; COPD, chronic obstructive pulmonary disease; CPM, counts per million reads . 18.20038455 doi: medRxiv preprint Abbreviations: ACE-2, angiotensin converting enzyme II; COPD, chronic obstructive pulmonary disease; CPM, counts per million reads ACE-2 gene expression in airway epithelia is inversely related to FEV1% predicted (p=0.0348)	./cache/cord-314868-ei2b8oqn.txt	./txt/cord-314868-ei2b8oqn.txt