id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311099-59pnm4fn	Lubel, John S	Liver disease and the renin–angiotensin system: Recent discoveries and clinical implications	2008-06-28		.txt	text/plain	7730	401	44	Drug therapies targeting the RAS by inhibiting Ang II formation (ACE inhibitors) or binding to its receptor (angiotensin receptor blockers) are now in widespread clinical use and have been shown to reduce tissue injury and fibrosis in cardiac and renal disease independently of their effects on blood pressure. Interestingly, ACE inhibitors and angiotensin receptor blockers increase Ang‐(1–7) production and it has been proposed that some of the beneficial effects of these drugs are mediated through upregulation of Ang‐(1–7) rather than inhibition of Ang II production or receptor binding. 42 A great deal of evidence supporting the role of the RAS in hepatic fibrosis has come from animal studies using ACE inhibitors and angiotensin receptor blockers (ARB). A pilot study examining the effects of 6 months of losartan treatment on liver fibrosis in chronic hepatitis C demonstrated a significant decrease in fibrosis stage in the treated group compared to control patients.	./cache/cord-311099-59pnm4fn.txt	./txt/cord-311099-59pnm4fn.txt