id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290148-6cxndab8	Rossi, Gian Paolo	Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients	2020-04-06		.txt	text/plain	3145	156	46	The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARSCoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and respiratory failure in patients with coronavirus disease-19 (COVID-19). However, they differ markedly: ACE-1 cleaves the dipeptide His-Leu from angiotensin I, thus generating angiotensin (Ang) II, which causes vaso-and broncho-constriction, increases vascular permeability, inflammation, and fibrosis and thereby promotes the development of ARDS and lung failure in patients infected with the SARS-CoV and SARS-CoV-2 (Yang et al., 2015) (Figure 1, panel B) . In one commentary ACE-2 was suggested to be secreted at higher amounts in patients with cardiovascular disease than in healthy individuals, and in another, it was also stated that 'ACE-2 levels can be increased by the use of ACEIs' , albeit no evidence of this occurring in the lungs Mechanisms of COVID-19 by which the SARS-COV-2 virus infects the lower airway cells and modalities to increase circulating soluble ACE-2 for therapeutic use.	./cache/cord-290148-6cxndab8.txt	./txt/cord-290148-6cxndab8.txt