id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259933-ggx4v0bz	Dalan, Rinkoo	The ACE-2 in COVID-19: Foe or Friend?	2020-04-27		.txt	text/plain	4187	225	44	The SARS-CoV-2, a positive strand RNA virus, has been seen to infect humans through the angiotensin converting enzyme -2 (ACE-2) receptor [9] . In individuals with hypertension, diabetes, and other cardiovascular disorders with vascular complications, the renin angiotensin system (RAS) is known to be activated with an increase in ACE activity and a downregulation of ACE-2. Therefore, it may be assumed that the inherent downregulation of the ACE-2-Ang-(1-7)-Mas axis (as seen in metabolic conditions) is exacerbated in the COVID-19 state because (i) the virus uses the peptidase domain of the enzyme for entry into the cells and (ii) there is a decrease in ACE-2 with an increase in ACE [9] . Individuals with underlying hypertension, type 2 diabetes, or cardiovascular disease are at higher risk for respiratory failure and mortality in COVID-19.	./cache/cord-259933-ggx4v0bz.txt	./txt/cord-259933-ggx4v0bz.txt