id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005931-iggkxbbf	Phillips, M. Ian	Brain renin angiotensin in disease	2008-04-02		.txt	text/plain	4345	257	47	Transgenic mice and rats bearing renin and extra copies of angiotensinogen genes revealed the importance of brain RAS. Taking the concept a step further, it was reasoned that if ANG II, formed by brain renin, was involved in hypertension, then inhibiting brain RAS would lower blood pressure. Minute injections of ANG II into key brain nuclei showed that ANG II could differentially produce pressor effects, elicit drinking, release vasopressin, inhibit the baroreflex, and increase sympathetic nervous system activity [20, 21] . In the double transgenic mice developed by Sigmund and colleagues [35] , to overexpress both human renin and human AGT so that they constantly have high ANG II levels, antisense to AT1R mRNA dramatically reduced the blood pressure. ACE-2, ANG (1-7), and Mas receptors are all localized in brain areas related to the control of cardiovascular function.	./cache/cord-005931-iggkxbbf.txt	./txt/cord-005931-iggkxbbf.txt