id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005386-p37rw8dh	Szolnoki, Zoltán	Coexistence of angiotensin II type-1 receptor A1166C and angiotensin-converting enzyme D/D polymorphism suggests susceptibility for small-vessel-associated ischemic stroke	2006		.txt	text/plain	3058	168	49	title: Coexistence of angiotensin II type-1 receptor A1166C and angiotensin-converting enzyme D/D polymorphism suggests susceptibility for small-vessel-associated ischemic stroke Our results demonstrate that ACE D/D and AT1R 1166C polymorphism were associated with the development of small-vessel ischemic stroke through a mutually facilitatory interplay between them. As both polymorphisms are associated with an enhanced activity of the angiotensin II-AT1R axis, we postulated at a clinical level, a synergistic effect between them as regards the evolution of ischemic stroke. A synergistic effect was found between the AT1R 1166C allele and the homozygous ACE D/D genotype in the small-vessel stroke subgroup (adjusted OR, 3.54; 95% CI, 1.88-7.16; p < 0.0005), the mixed vascular type (adjusted OR, 2.41; 95% CI, 1.2-5.1; p < 0.05), and the overall ischemic stroke group (adjusted OR, 2.42; 95% CI, 1.51-3.82; p < 0.005) ( Table 3 ).	./cache/cord-005386-p37rw8dh.txt	./txt/cord-005386-p37rw8dh.txt