id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002468-onpmkjaz	Roca-Ho, Heleia	Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse	2017-03-05		.txt	text/plain	5850	370	59	In this sense, since local RAS has been described, the aim of this study is to characterize angiotensin converting enzyme (ACE) and ACE2 activities, as well as protein expression, in several tissues of the non-obese diabetic (NOD) mice model. At cardiac level, there was a In serum samples, there was a significant increase of ACE2 activity in DB mice at early and late stages of diabetes as compared to CONT (p = 0.0003 and p = 0.0003, respectively) and insulin administration significantly decreased ACE2 activity in DB mice at early and late stages (p = 0.001 and p = 0.001, respectively) ( Figure 4a ). At cardiac level, there was a significant increase of ACE2 activity in DB mice in both early and late stages of DB as compared to CONT mice (p = 0.011 and p = 0.029, respectively), however, insulin administration did not modify this pattern (p = NS) (Figure 4b) .	./cache/cord-002468-onpmkjaz.txt	./txt/cord-002468-onpmkjaz.txt