id	sid	tid	token	lemma	pos
cord-339752-o6atz33c	1	1	key	key	NN
cord-339752-o6atz33c	1	2	:	:	:
cord-339752-o6atz33c	2	1	cord-339752-o6atz33c	cord-339752-o6atz33c	NFP
cord-339752-o6atz33c	2	2	authors	author	NNS
cord-339752-o6atz33c	2	3	:	:	:
cord-339752-o6atz33c	2	4	Xiao	Xiao	NNP
cord-339752-o6atz33c	2	5	,	,	,
cord-339752-o6atz33c	2	6	Li	Li	NNP
cord-339752-o6atz33c	2	7	;	;	:
cord-339752-o6atz33c	2	8	Sakagami	Sakagami	NNP
cord-339752-o6atz33c	2	9	,	,	,
cord-339752-o6atz33c	2	10	Hiroshi	Hiroshi	NNP
cord-339752-o6atz33c	2	11	;	;	:
cord-339752-o6atz33c	2	12	Miwa	Miwa	NNP
cord-339752-o6atz33c	2	13	,	,	,
cord-339752-o6atz33c	3	1	Nobuhiko	Nobuhiko	NNP
cord-339752-o6atz33c	3	2	title	title	NN
cord-339752-o6atz33c	3	3	:	:	:
cord-339752-o6atz33c	4	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	4	2	:	:	:
cord-339752-o6atz33c	4	3	The	the	DT
cord-339752-o6atz33c	4	4	Key	Key	NNP
cord-339752-o6atz33c	4	5	Molecule	Molecule	NNP
cord-339752-o6atz33c	4	6	for	for	IN
cord-339752-o6atz33c	4	7	Understanding	understand	VBG
cord-339752-o6atz33c	4	8	the	the	DT
cord-339752-o6atz33c	4	9	Pathophysiology	Pathophysiology	NNP
cord-339752-o6atz33c	4	10	of	of	IN
cord-339752-o6atz33c	4	11	Severe	severe	JJ
cord-339752-o6atz33c	4	12	and	and	CC
cord-339752-o6atz33c	4	13	Critical	Critical	NNP
cord-339752-o6atz33c	4	14	Conditions	Conditions	NNPS
cord-339752-o6atz33c	4	15	of	of	IN
cord-339752-o6atz33c	4	16	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	4	17	:	:	:
cord-339752-o6atz33c	4	18	Demon	Demon	NNP
cord-339752-o6atz33c	4	19	or	or	CC
cord-339752-o6atz33c	4	20	Angel	Angel	NNP
cord-339752-o6atz33c	4	21	?	?	.
cord-339752-o6atz33c	5	1	date	date	NN
cord-339752-o6atz33c	5	2	:	:	:
cord-339752-o6atz33c	5	3	2020	2020	CD
cord-339752-o6atz33c	5	4	-	-	HYPH
cord-339752-o6atz33c	5	5	04	04	CD
cord-339752-o6atz33c	5	6	-	-	HYPH
cord-339752-o6atz33c	5	7	28	28	CD
cord-339752-o6atz33c	5	8	journal	journal	NN
cord-339752-o6atz33c	5	9	:	:	:
cord-339752-o6atz33c	6	1	Viruses	virus	NNS
cord-339752-o6atz33c	6	2	DOI	DOI	NNP
cord-339752-o6atz33c	6	3	:	:	:
cord-339752-o6atz33c	7	1	10.3390	10.3390	CD
cord-339752-o6atz33c	7	2	/	/	SYM
cord-339752-o6atz33c	7	3	v12050491	v12050491	NNP
cord-339752-o6atz33c	7	4	sha	sha	NNP
cord-339752-o6atz33c	7	5	:	:	:
cord-339752-o6atz33c	7	6	953b5dd4d4b0426d9920a754b5daa634eb45be9b	953b5dd4d4b0426d9920a754b5daa634eb45be9b	CD
cord-339752-o6atz33c	7	7	doc_id	doc_id	CD
cord-339752-o6atz33c	7	8	:	:	:
cord-339752-o6atz33c	7	9	339752	339752	CD
cord-339752-o6atz33c	7	10	cord_uid	cord_uid	NNS
cord-339752-o6atz33c	7	11	:	:	:
cord-339752-o6atz33c	7	12	o6atz33c	o6atz33c	NNP
cord-339752-o6atz33c	8	1	Recently	recently	RB
cord-339752-o6atz33c	8	2	,	,	,
cord-339752-o6atz33c	8	3	the	the	DT
cord-339752-o6atz33c	8	4	SARS	SARS	NNP
cord-339752-o6atz33c	8	5	-	-	HYPH
cord-339752-o6atz33c	8	6	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	8	7	induced	induce	VBN
cord-339752-o6atz33c	8	8	disease	disease	NN
cord-339752-o6atz33c	9	1	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	9	2	has	have	VBZ
cord-339752-o6atz33c	9	3	spread	spread	VBN
cord-339752-o6atz33c	9	4	all	all	RB
cord-339752-o6atz33c	9	5	over	over	IN
cord-339752-o6atz33c	9	6	the	the	DT
cord-339752-o6atz33c	9	7	world	world	NN
cord-339752-o6atz33c	9	8	.	.	.
cord-339752-o6atz33c	10	1	Nearly	nearly	RB
cord-339752-o6atz33c	10	2	20	20	CD
cord-339752-o6atz33c	10	3	%	%	NN
cord-339752-o6atz33c	10	4	of	of	IN
cord-339752-o6atz33c	10	5	the	the	DT
cord-339752-o6atz33c	10	6	patients	patient	NNS
cord-339752-o6atz33c	10	7	have	have	VBP
cord-339752-o6atz33c	10	8	severe	severe	JJ
cord-339752-o6atz33c	10	9	or	or	CC
cord-339752-o6atz33c	10	10	critical	critical	JJ
cord-339752-o6atz33c	10	11	conditions	condition	NNS
cord-339752-o6atz33c	10	12	.	.	.
cord-339752-o6atz33c	11	1	SARS	SARS	NNP
cord-339752-o6atz33c	11	2	-	-	HYPH
cord-339752-o6atz33c	11	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	11	4	exploits	exploit	VBZ
cord-339752-o6atz33c	11	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	11	6	for	for	IN
cord-339752-o6atz33c	11	7	host	host	NN
cord-339752-o6atz33c	11	8	cell	cell	NN
cord-339752-o6atz33c	11	9	entry	entry	NN
cord-339752-o6atz33c	11	10	.	.	.
cord-339752-o6atz33c	12	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	12	2	plays	play	VBZ
cord-339752-o6atz33c	12	3	an	an	DT
cord-339752-o6atz33c	12	4	essential	essential	JJ
cord-339752-o6atz33c	12	5	role	role	NN
cord-339752-o6atz33c	12	6	in	in	IN
cord-339752-o6atz33c	12	7	the	the	DT
cord-339752-o6atz33c	12	8	renin	renin	NN
cord-339752-o6atz33c	12	9	–	–	:
cord-339752-o6atz33c	12	10	angiotensin	angiotensin	NN
cord-339752-o6atz33c	12	11	–	–	:
cord-339752-o6atz33c	12	12	aldosterone	aldosterone	NN
cord-339752-o6atz33c	12	13	system	system	NN
cord-339752-o6atz33c	12	14	(	(	-LRB-
cord-339752-o6atz33c	12	15	RAAS	RAAS	NNP
cord-339752-o6atz33c	12	16	)	)	-RRB-
cord-339752-o6atz33c	12	17	,	,	,
cord-339752-o6atz33c	12	18	which	which	WDT
cord-339752-o6atz33c	12	19	regulates	regulate	VBZ
cord-339752-o6atz33c	12	20	blood	blood	NN
cord-339752-o6atz33c	12	21	pressure	pressure	NN
cord-339752-o6atz33c	12	22	and	and	CC
cord-339752-o6atz33c	12	23	fluid	fluid	JJ
cord-339752-o6atz33c	12	24	balance	balance	NN
cord-339752-o6atz33c	12	25	.	.	.
cord-339752-o6atz33c	13	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	13	2	also	also	RB
cord-339752-o6atz33c	13	3	protects	protect	VBZ
cord-339752-o6atz33c	13	4	organs	organ	NNS
cord-339752-o6atz33c	13	5	from	from	IN
cord-339752-o6atz33c	13	6	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	13	7	injuries	injury	NNS
cord-339752-o6atz33c	13	8	and	and	CC
cord-339752-o6atz33c	13	9	regulates	regulate	VBZ
cord-339752-o6atz33c	13	10	intestinal	intestinal	JJ
cord-339752-o6atz33c	13	11	functions	function	NNS
cord-339752-o6atz33c	13	12	.	.	.
cord-339752-o6atz33c	14	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	14	2	can	can	MD
cord-339752-o6atz33c	14	3	be	be	VB
cord-339752-o6atz33c	14	4	shed	shed	VBN
cord-339752-o6atz33c	14	5	by	by	IN
cord-339752-o6atz33c	14	6	two	two	CD
cord-339752-o6atz33c	14	7	proteases	protease	NNS
cord-339752-o6atz33c	14	8	,	,	,
cord-339752-o6atz33c	14	9	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	14	10	and	and	CC
cord-339752-o6atz33c	14	11	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	14	12	.	.	.
cord-339752-o6atz33c	15	1	TMPRSS2-cleaved	TMPRSS2-cleaved	NNP
cord-339752-o6atz33c	15	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	15	3	allows	allow	VBZ
cord-339752-o6atz33c	15	4	SARS	SARS	NNP
cord-339752-o6atz33c	15	5	-	-	HYPH
cord-339752-o6atz33c	15	6	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	15	7	cell	cell	NN
cord-339752-o6atz33c	15	8	entry	entry	NN
cord-339752-o6atz33c	15	9	,	,	,
cord-339752-o6atz33c	15	10	whereas	whereas	IN
cord-339752-o6atz33c	15	11	ADAM17-cleaved	ADAM17-cleaved	NNP
cord-339752-o6atz33c	15	12	ACE2	ACE2	NNP
cord-339752-o6atz33c	15	13	offers	offer	VBZ
cord-339752-o6atz33c	15	14	protection	protection	NN
cord-339752-o6atz33c	15	15	to	to	IN
cord-339752-o6atz33c	15	16	organs	organ	NNS
cord-339752-o6atz33c	15	17	.	.	.
cord-339752-o6atz33c	16	1	SARS	SARS	NNP
cord-339752-o6atz33c	16	2	-	-	HYPH
cord-339752-o6atz33c	16	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	16	4	infection	infection	NN
cord-339752-o6atz33c	16	5	-	-	HYPH
cord-339752-o6atz33c	16	6	caused	cause	VBN
cord-339752-o6atz33c	16	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	16	8	dysfunction	dysfunction	NN
cord-339752-o6atz33c	16	9	worsens	worsen	VBZ
cord-339752-o6atz33c	16	10	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	16	11	and	and	CC
cord-339752-o6atz33c	16	12	could	could	MD
cord-339752-o6atz33c	16	13	initiate	initiate	VB
cord-339752-o6atz33c	16	14	multi	multi	JJ
cord-339752-o6atz33c	16	15	-	-	JJ
cord-339752-o6atz33c	16	16	organ	organ	JJ
cord-339752-o6atz33c	16	17	failure	failure	NN
cord-339752-o6atz33c	16	18	.	.	.
cord-339752-o6atz33c	17	1	Here	here	RB
cord-339752-o6atz33c	17	2	,	,	,
cord-339752-o6atz33c	17	3	we	-PRON-	PRP
cord-339752-o6atz33c	17	4	will	will	MD
cord-339752-o6atz33c	17	5	explain	explain	VB
cord-339752-o6atz33c	17	6	the	the	DT
cord-339752-o6atz33c	17	7	role	role	NN
cord-339752-o6atz33c	17	8	of	of	IN
cord-339752-o6atz33c	17	9	ACE2	ACE2	NNP
cord-339752-o6atz33c	17	10	in	in	IN
cord-339752-o6atz33c	17	11	the	the	DT
cord-339752-o6atz33c	17	12	pathogenesis	pathogenesis	NN
cord-339752-o6atz33c	17	13	of	of	IN
cord-339752-o6atz33c	17	14	severe	severe	JJ
cord-339752-o6atz33c	17	15	and	and	CC
cord-339752-o6atz33c	17	16	critical	critical	JJ
cord-339752-o6atz33c	17	17	conditions	condition	NNS
cord-339752-o6atz33c	17	18	of	of	IN
cord-339752-o6atz33c	17	19	COVID-19	covid-19	VB
cord-339752-o6atz33c	17	20	and	and	CC
cord-339752-o6atz33c	17	21	discuss	discuss	VB
cord-339752-o6atz33c	17	22	auspicious	auspicious	JJ
cord-339752-o6atz33c	17	23	strategies	strategy	NNS
cord-339752-o6atz33c	17	24	for	for	IN
cord-339752-o6atz33c	17	25	controlling	control	VBG
cord-339752-o6atz33c	17	26	the	the	DT
cord-339752-o6atz33c	17	27	disease	disease	NN
cord-339752-o6atz33c	17	28	.	.	.
cord-339752-o6atz33c	18	1	Since	since	IN
cord-339752-o6atz33c	18	2	December	December	NNP
cord-339752-o6atz33c	18	3	2019	2019	CD
cord-339752-o6atz33c	18	4	,	,	,
cord-339752-o6atz33c	18	5	the	the	DT
cord-339752-o6atz33c	18	6	new	new	JJ
cord-339752-o6atz33c	18	7	coronavirus	coronavirus	NN
cord-339752-o6atz33c	18	8	(	(	-LRB-
cord-339752-o6atz33c	18	9	severe	severe	JJ
cord-339752-o6atz33c	18	10	acute	acute	JJ
cord-339752-o6atz33c	18	11	respiratory	respiratory	JJ
cord-339752-o6atz33c	18	12	syndrome	syndrome	NN
cord-339752-o6atz33c	18	13	coronavirus	coronavirus	NN
cord-339752-o6atz33c	18	14	2	2	CD
cord-339752-o6atz33c	18	15	,	,	,
cord-339752-o6atz33c	18	16	SARS	SARS	NNP
cord-339752-o6atz33c	18	17	-	-	HYPH
cord-339752-o6atz33c	18	18	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	18	19	)	)	-RRB-
cord-339752-o6atz33c	18	20	induced	induce	VBN
cord-339752-o6atz33c	18	21	disease	disease	NN
cord-339752-o6atz33c	18	22	,	,	,
cord-339752-o6atz33c	18	23	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	18	24	,	,	,
cord-339752-o6atz33c	18	25	has	have	VBZ
cord-339752-o6atz33c	18	26	spread	spread	VBN
cord-339752-o6atz33c	18	27	rapidly	rapidly	RB
cord-339752-o6atz33c	18	28	all	all	RB
cord-339752-o6atz33c	18	29	over	over	IN
cord-339752-o6atz33c	18	30	the	the	DT
cord-339752-o6atz33c	18	31	planet	planet	NN
cord-339752-o6atz33c	18	32	.	.	.
cord-339752-o6atz33c	19	1	As	as	IN
cord-339752-o6atz33c	19	2	shown	show	VBN
cord-339752-o6atz33c	19	3	in	in	IN
cord-339752-o6atz33c	19	4	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	19	5	Dashboard	Dashboard	NNP
cord-339752-o6atz33c	19	6	by	by	IN
cord-339752-o6atz33c	19	7	the	the	DT
cord-339752-o6atz33c	19	8	Center	Center	NNP
cord-339752-o6atz33c	19	9	for	for	IN
cord-339752-o6atz33c	19	10	Systems	Systems	NNP
cord-339752-o6atz33c	19	11	Science	Science	NNP
cord-339752-o6atz33c	19	12	and	and	CC
cord-339752-o6atz33c	19	13	Engineering	Engineering	NNP
cord-339752-o6atz33c	19	14	(	(	-LRB-
cord-339752-o6atz33c	19	15	CSSE	CSSE	NNP
cord-339752-o6atz33c	19	16	)	)	-RRB-
cord-339752-o6atz33c	19	17	at	at	IN
cord-339752-o6atz33c	19	18	Johns	Johns	NNP
cord-339752-o6atz33c	19	19	Hopkins	Hopkins	NNP
cord-339752-o6atz33c	19	20	University	University	NNP
cord-339752-o6atz33c	19	21	(	(	-LRB-
cord-339752-o6atz33c	19	22	JHU	JHU	NNP
cord-339752-o6atz33c	19	23	)	)	-RRB-
cord-339752-o6atz33c	19	24	,	,	,
cord-339752-o6atz33c	19	25	up	up	IN
cord-339752-o6atz33c	19	26	to	to	IN
cord-339752-o6atz33c	19	27	date	date	NN
cord-339752-o6atz33c	19	28	2,703,615	2,703,615	CD
cord-339752-o6atz33c	19	29	people	people	NNS
cord-339752-o6atz33c	19	30	have	have	VBP
cord-339752-o6atz33c	19	31	been	be	VBN
cord-339752-o6atz33c	19	32	infected	infect	VBN
cord-339752-o6atz33c	19	33	and	and	CC
cord-339752-o6atz33c	19	34	190,490	190,490	CD
cord-339752-o6atz33c	19	35	deaths	death	NNS
cord-339752-o6atz33c	19	36	have	have	VBP
cord-339752-o6atz33c	19	37	been	be	VBN
cord-339752-o6atz33c	19	38	confirmed	confirm	VBN
cord-339752-o6atz33c	19	39	worldwide	worldwide	RB
cord-339752-o6atz33c	19	40	[	[	-LRB-
cord-339752-o6atz33c	19	41	1	1	CD
cord-339752-o6atz33c	19	42	]	]	-RRB-
cord-339752-o6atz33c	19	43	.WHO	.WHO	NNP
cord-339752-o6atz33c	19	44	officially	officially	RB
cord-339752-o6atz33c	19	45	declared	declare	VBD
cord-339752-o6atz33c	19	46	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	19	47	a	a	DT
cord-339752-o6atz33c	19	48	pandemic	pandemic	NN
cord-339752-o6atz33c	19	49	on	on	IN
cord-339752-o6atz33c	19	50	March	March	NNP
cord-339752-o6atz33c	19	51	12th	12th	NN
cord-339752-o6atz33c	19	52	,	,	,
cord-339752-o6atz33c	19	53	2020	2020	CD
cord-339752-o6atz33c	19	54	.	.	.
cord-339752-o6atz33c	20	1	According	accord	VBG
cord-339752-o6atz33c	20	2	to	to	IN
cord-339752-o6atz33c	20	3	a	a	DT
cord-339752-o6atz33c	20	4	report	report	NN
cord-339752-o6atz33c	20	5	based	base	VBN
cord-339752-o6atz33c	20	6	on	on	IN
cord-339752-o6atz33c	20	7	72,314	72,314	CD
cord-339752-o6atz33c	20	8	cases	case	NNS
cord-339752-o6atz33c	20	9	(	(	-LRB-
cord-339752-o6atz33c	20	10	test	test	NN
cord-339752-o6atz33c	20	11	confirmed	confirm	VBD
cord-339752-o6atz33c	20	12	cases	case	NNS
cord-339752-o6atz33c	20	13	:	:	:
cord-339752-o6atz33c	20	14	44,672	44,672	CD
cord-339752-o6atz33c	20	15	(	(	-LRB-
cord-339752-o6atz33c	20	16	62	62	CD
cord-339752-o6atz33c	20	17	%	%	NN
cord-339752-o6atz33c	20	18	)	)	-RRB-
cord-339752-o6atz33c	20	19	from	from	IN
cord-339752-o6atz33c	20	20	the	the	DT
cord-339752-o6atz33c	20	21	Chinese	Chinese	NNP
cord-339752-o6atz33c	20	22	Center	Center	NNP
cord-339752-o6atz33c	20	23	for	for	IN
cord-339752-o6atz33c	20	24	Disease	Disease	NNP
cord-339752-o6atz33c	20	25	Control	Control	NNP
cord-339752-o6atz33c	20	26	and	and	CC
cord-339752-o6atz33c	20	27	Prevention	Prevention	NNP
cord-339752-o6atz33c	20	28	,	,	,
cord-339752-o6atz33c	20	29	81	81	CD
cord-339752-o6atz33c	20	30	%	%	NN
cord-339752-o6atz33c	20	31	of	of	IN
cord-339752-o6atz33c	20	32	COVID-19	covid-19	JJ
cord-339752-o6atz33c	20	33	patients	patient	NNS
cord-339752-o6atz33c	20	34	have	have	VBP
cord-339752-o6atz33c	20	35	cold	cold	JJ
cord-339752-o6atz33c	20	36	-	-	HYPH
cord-339752-o6atz33c	20	37	like	like	JJ
cord-339752-o6atz33c	20	38	symptoms	symptom	NNS
cord-339752-o6atz33c	20	39	and	and	CC
cord-339752-o6atz33c	20	40	mild	mild	JJ
cord-339752-o6atz33c	20	41	pneumonia	pneumonia	NN
cord-339752-o6atz33c	20	42	,	,	,
cord-339752-o6atz33c	20	43	14	14	CD
cord-339752-o6atz33c	20	44	%	%	NN
cord-339752-o6atz33c	20	45	have	have	VBP
cord-339752-o6atz33c	20	46	severe	severe	JJ
cord-339752-o6atz33c	20	47	respiratory	respiratory	JJ
cord-339752-o6atz33c	20	48	inflammation	inflammation	NN
cord-339752-o6atz33c	20	49	,	,	,
cord-339752-o6atz33c	20	50	and	and	CC
cord-339752-o6atz33c	20	51	5	5	CD
cord-339752-o6atz33c	20	52	%	%	NN
cord-339752-o6atz33c	20	53	have	have	VBP
cord-339752-o6atz33c	20	54	critical	critical	JJ
cord-339752-o6atz33c	20	55	conditions	condition	NNS
cord-339752-o6atz33c	20	56	including	include	VBG
cord-339752-o6atz33c	20	57	respiratory	respiratory	JJ
cord-339752-o6atz33c	20	58	failure	failure	NN
cord-339752-o6atz33c	20	59	,	,	,
cord-339752-o6atz33c	20	60	septic	septic	JJ
cord-339752-o6atz33c	20	61	shock	shock	NN
cord-339752-o6atz33c	20	62	,	,	,
cord-339752-o6atz33c	20	63	and/or	and/or	CC
cord-339752-o6atz33c	20	64	multiple	multiple	JJ
cord-339752-o6atz33c	20	65	organ	organ	NN
cord-339752-o6atz33c	20	66	dysfunction	dysfunction	NN
cord-339752-o6atz33c	20	67	or	or	CC
cord-339752-o6atz33c	20	68	failure	failure	NN
cord-339752-o6atz33c	20	69	.	.	.
cord-339752-o6atz33c	21	1	The	the	DT
cord-339752-o6atz33c	21	2	mortality	mortality	NN
cord-339752-o6atz33c	21	3	is	be	VBZ
cord-339752-o6atz33c	21	4	2.3	2.3	CD
cord-339752-o6atz33c	21	5	%	%	NN
cord-339752-o6atz33c	21	6	(	(	-LRB-
cord-339752-o6atz33c	21	7	49.0	49.0	CD
cord-339752-o6atz33c	21	8	%	%	NN
cord-339752-o6atz33c	21	9	in	in	IN
cord-339752-o6atz33c	21	10	critical	critical	JJ
cord-339752-o6atz33c	21	11	cases	case	NNS
cord-339752-o6atz33c	21	12	)	)	-RRB-
cord-339752-o6atz33c	21	13	[	[	-LRB-
cord-339752-o6atz33c	21	14	2	2	CD
cord-339752-o6atz33c	21	15	]	]	-RRB-
cord-339752-o6atz33c	21	16	.	.	.
cord-339752-o6atz33c	22	1	Since	since	IN
cord-339752-o6atz33c	22	2	the	the	DT
cord-339752-o6atz33c	22	3	rates	rate	NNS
cord-339752-o6atz33c	22	4	of	of	IN
cord-339752-o6atz33c	22	5	severe	severe	JJ
cord-339752-o6atz33c	22	6	and	and	CC
cord-339752-o6atz33c	22	7	critical	critical	JJ
cord-339752-o6atz33c	22	8	cases	case	NNS
cord-339752-o6atz33c	22	9	are	be	VBP
cord-339752-o6atz33c	22	10	much	much	RB
cord-339752-o6atz33c	22	11	higher	high	JJR
cord-339752-o6atz33c	22	12	than	than	IN
cord-339752-o6atz33c	22	13	seasonal	seasonal	JJ
cord-339752-o6atz33c	22	14	influenza	influenza	NN
cord-339752-o6atz33c	22	15	,	,	,
cord-339752-o6atz33c	22	16	it	-PRON-	PRP
cord-339752-o6atz33c	22	17	is	be	VBZ
cord-339752-o6atz33c	22	18	essential	essential	JJ
cord-339752-o6atz33c	22	19	to	to	TO
cord-339752-o6atz33c	22	20	understand	understand	VB
cord-339752-o6atz33c	22	21	the	the	DT
cord-339752-o6atz33c	22	22	pathophysiology	pathophysiology	NN
cord-339752-o6atz33c	22	23	and	and	CC
cord-339752-o6atz33c	22	24	then	then	RB
cord-339752-o6atz33c	22	25	devise	devise	VB
cord-339752-o6atz33c	22	26	strategies	strategy	NNS
cord-339752-o6atz33c	22	27	to	to	TO
cord-339752-o6atz33c	22	28	fight	fight	VB
cord-339752-o6atz33c	22	29	the	the	DT
cord-339752-o6atz33c	22	30	disease	disease	NN
cord-339752-o6atz33c	22	31	.	.	.
cord-339752-o6atz33c	23	1	SARS	SARS	NNP
cord-339752-o6atz33c	23	2	-	-	HYPH
cord-339752-o6atz33c	23	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	23	4	is	be	VBZ
cord-339752-o6atz33c	23	5	a	a	DT
cord-339752-o6atz33c	23	6	positive	positive	JJ
cord-339752-o6atz33c	23	7	-	-	HYPH
cord-339752-o6atz33c	23	8	sense	sense	NN
cord-339752-o6atz33c	23	9	single	single	JJ
cord-339752-o6atz33c	23	10	-	-	HYPH
cord-339752-o6atz33c	23	11	stranded	strand	VBN
cord-339752-o6atz33c	23	12	RNA	RNA	NNP
cord-339752-o6atz33c	23	13	virus	virus	NN
cord-339752-o6atz33c	23	14	with	with	IN
cord-339752-o6atz33c	23	15	a	a	DT
cord-339752-o6atz33c	23	16	crown	crown	NN
cord-339752-o6atz33c	23	17	-	-	HYPH
cord-339752-o6atz33c	23	18	like	like	JJ
cord-339752-o6atz33c	23	19	appearance	appearance	NN
cord-339752-o6atz33c	23	20	of	of	IN
cord-339752-o6atz33c	23	21	spike	spike	NN
cord-339752-o6atz33c	23	22	proteins	protein	NNS
cord-339752-o6atz33c	23	23	(	(	-LRB-
cord-339752-o6atz33c	23	24	S	s	NN
cord-339752-o6atz33c	23	25	proteins	protein	NNS
cord-339752-o6atz33c	23	26	)	)	-RRB-
cord-339752-o6atz33c	24	1	that	that	DT
cord-339752-o6atz33c	24	2	project	project	NN
cord-339752-o6atz33c	24	3	from	from	IN
cord-339752-o6atz33c	24	4	their	-PRON-	PRP$
cord-339752-o6atz33c	24	5	envelope	envelope	NN
cord-339752-o6atz33c	24	6	.	.	.
cord-339752-o6atz33c	25	1	Similar	similar	JJ
cord-339752-o6atz33c	25	2	to	to	IN
cord-339752-o6atz33c	25	3	SARS	SARS	NNP
cord-339752-o6atz33c	25	4	(	(	-LRB-
cord-339752-o6atz33c	25	5	severe	severe	JJ
cord-339752-o6atz33c	25	6	acute	acute	JJ
cord-339752-o6atz33c	25	7	respiratory	respiratory	JJ
cord-339752-o6atz33c	25	8	syndrome	syndrome	NN
cord-339752-o6atz33c	25	9	,	,	,
cord-339752-o6atz33c	25	10	[	[	-LRB-
cord-339752-o6atz33c	25	11	2002	2002	CD
cord-339752-o6atz33c	25	12	]	]	-RRB-
cord-339752-o6atz33c	26	1	[	[	-LRB-
cord-339752-o6atz33c	26	2	2003	2003	CD
cord-339752-o6atz33c	26	3	]	]	-RRB-
cord-339752-o6atz33c	26	4	coronavirus	coronavirus	NN
cord-339752-o6atz33c	26	5	(	(	-LRB-
cord-339752-o6atz33c	26	6	SARS	SARS	NNP
cord-339752-o6atz33c	26	7	-	-	HYPH
cord-339752-o6atz33c	26	8	CoV	CoV	NNP
cord-339752-o6atz33c	26	9	)	)	-RRB-
cord-339752-o6atz33c	27	1	[	[	-LRB-
cord-339752-o6atz33c	27	2	3	3	CD
cord-339752-o6atz33c	27	3	]	]	-RRB-
cord-339752-o6atz33c	27	4	,	,	,
cord-339752-o6atz33c	27	5	SARS	SARS	NNP
cord-339752-o6atz33c	27	6	-	-	HYPH
cord-339752-o6atz33c	27	7	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	27	8	primarily	primarily	RB
cord-339752-o6atz33c	27	9	uses	use	VBZ
cord-339752-o6atz33c	27	10	the	the	DT
cord-339752-o6atz33c	27	11	S	S	NNP
cord-339752-o6atz33c	27	12	protein	protein	NN
cord-339752-o6atz33c	27	13	to	to	TO
cord-339752-o6atz33c	27	14	invade	invade	VB
cord-339752-o6atz33c	27	15	host	host	NN
cord-339752-o6atz33c	27	16	cells	cell	NNS
cord-339752-o6atz33c	27	17	through	through	IN
cord-339752-o6atz33c	27	18	ACE2	ACE2	NNP
cord-339752-o6atz33c	27	19	,	,	,
cord-339752-o6atz33c	27	20	an	an	DT
cord-339752-o6atz33c	27	21	enzyme	enzyme	NN
cord-339752-o6atz33c	27	22	which	which	WDT
cord-339752-o6atz33c	27	23	is	be	VBZ
cord-339752-o6atz33c	27	24	known	know	VBN
cord-339752-o6atz33c	27	25	to	to	TO
cord-339752-o6atz33c	27	26	be	be	VB
cord-339752-o6atz33c	27	27	important	important	JJ
cord-339752-o6atz33c	27	28	in	in	IN
cord-339752-o6atz33c	27	29	the	the	DT
cord-339752-o6atz33c	27	30	renin	renin	NN
cord-339752-o6atz33c	27	31	-	-	HYPH
cord-339752-o6atz33c	27	32	angiotensin	angiotensin	NN
cord-339752-o6atz33c	27	33	-	-	HYPH
cord-339752-o6atz33c	27	34	aldosterone	aldosterone	NN
cord-339752-o6atz33c	27	35	system	system	NN
cord-339752-o6atz33c	27	36	(	(	-LRB-
cord-339752-o6atz33c	27	37	RAAS	RAAS	NNP
cord-339752-o6atz33c	27	38	)	)	-RRB-
cord-339752-o6atz33c	27	39	[	[	-LRB-
cord-339752-o6atz33c	27	40	4	4	CD
cord-339752-o6atz33c	27	41	,	,	,
cord-339752-o6atz33c	27	42	5	5	CD
cord-339752-o6atz33c	27	43	]	]	-RRB-
cord-339752-o6atz33c	27	44	.	.	.
cord-339752-o6atz33c	28	1	Cellular	Cellular	NNP
cord-339752-o6atz33c	28	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	28	3	,	,	,
cord-339752-o6atz33c	28	4	ADAM17	adam17	UH
cord-339752-o6atz33c	28	5	,	,	,
cord-339752-o6atz33c	28	6	and	and	CC
cord-339752-o6atz33c	28	7	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	28	8	are	be	VBP
cord-339752-o6atz33c	28	9	all	all	DT
cord-339752-o6atz33c	28	10	expressed	express	VBN
cord-339752-o6atz33c	28	11	on	on	IN
cord-339752-o6atz33c	28	12	the	the	DT
cord-339752-o6atz33c	28	13	cell	cell	NN
cord-339752-o6atz33c	28	14	membrane	membrane	NN
cord-339752-o6atz33c	28	15	.	.	.
cord-339752-o6atz33c	29	1	After	after	IN
cord-339752-o6atz33c	29	2	being	be	VBG
cord-339752-o6atz33c	29	3	shed	shed	VBN
cord-339752-o6atz33c	29	4	by	by	IN
cord-339752-o6atz33c	29	5	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	29	6	,	,	,
cord-339752-o6atz33c	29	7	soluble	soluble	JJ
cord-339752-o6atz33c	29	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	29	9	is	be	VBZ
cord-339752-o6atz33c	29	10	released	release	VBN
cord-339752-o6atz33c	29	11	from	from	IN
cord-339752-o6atz33c	29	12	its	-PRON-	PRP$
cord-339752-o6atz33c	29	13	full	full	JJ
cord-339752-o6atz33c	29	14	-	-	HYPH
cord-339752-o6atz33c	29	15	length	length	NN
cord-339752-o6atz33c	29	16	form	form	NN
cord-339752-o6atz33c	29	17	to	to	TO
cord-339752-o6atz33c	29	18	counteract	counteract	VB
cord-339752-o6atz33c	29	19	the	the	DT
cord-339752-o6atz33c	29	20	effects	effect	NNS
cord-339752-o6atz33c	29	21	of	of	IN
cord-339752-o6atz33c	29	22	Ang	Ang	NNP
cord-339752-o6atz33c	29	23	II	II	NNP
cord-339752-o6atz33c	29	24	signaling	signal	VBG
cord-339752-o6atz33c	29	25	.	.	.
cord-339752-o6atz33c	30	1	Alternatively	alternatively	RB
cord-339752-o6atz33c	30	2	,	,	,
cord-339752-o6atz33c	30	3	cellular	cellular	JJ
cord-339752-o6atz33c	30	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	30	5	is	be	VBZ
cord-339752-o6atz33c	30	6	also	also	RB
cord-339752-o6atz33c	30	7	shed	shed	VBN
cord-339752-o6atz33c	30	8	by	by	IN
cord-339752-o6atz33c	30	9	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	30	10	,	,	,
cord-339752-o6atz33c	30	11	which	which	WDT
cord-339752-o6atz33c	30	12	results	result	VBZ
cord-339752-o6atz33c	30	13	in	in	IN
cord-339752-o6atz33c	30	14	SARS	SARS	NNP
cord-339752-o6atz33c	30	15	-	-	HYPH
cord-339752-o6atz33c	30	16	CoV-2-cell	CoV-2-cell	NNP
cord-339752-o6atz33c	30	17	membrane	membrane	NN
cord-339752-o6atz33c	30	18	fusion	fusion	NN
cord-339752-o6atz33c	30	19	.	.	.
cord-339752-o6atz33c	31	1	SARS	SARS	NNP
cord-339752-o6atz33c	31	2	-	-	HYPH
cord-339752-o6atz33c	31	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	31	4	RNA	RNA	NNP
cord-339752-o6atz33c	31	5	is	be	VBZ
cord-339752-o6atz33c	31	6	then	then	RB
cord-339752-o6atz33c	31	7	released	release	VBN
cord-339752-o6atz33c	31	8	into	into	IN
cord-339752-o6atz33c	31	9	the	the	DT
cord-339752-o6atz33c	31	10	cytoplasm	cytoplasm	NN
cord-339752-o6atz33c	31	11	and	and	CC
cord-339752-o6atz33c	31	12	viral	viral	JJ
cord-339752-o6atz33c	31	13	replication	replication	NN
cord-339752-o6atz33c	31	14	is	be	VBZ
cord-339752-o6atz33c	31	15	efficiently	efficiently	RB
cord-339752-o6atz33c	31	16	processed	process	VBN
cord-339752-o6atz33c	31	17	.	.	.
cord-339752-o6atz33c	32	1	Because	because	IN
cord-339752-o6atz33c	32	2	soluble	soluble	JJ
cord-339752-o6atz33c	32	3	ACE2	ACE2	NNP
cord-339752-o6atz33c	32	4	contains	contain	VBZ
cord-339752-o6atz33c	32	5	the	the	DT
cord-339752-o6atz33c	32	6	virus	virus	NN
cord-339752-o6atz33c	32	7	binding	bind	VBG
cord-339752-o6atz33c	32	8	site	site	NN
cord-339752-o6atz33c	32	9	,	,	,
cord-339752-o6atz33c	32	10	it	-PRON-	PRP
cord-339752-o6atz33c	32	11	can	can	MD
cord-339752-o6atz33c	32	12	also	also	RB
cord-339752-o6atz33c	32	13	bind	bind	VB
cord-339752-o6atz33c	32	14	to	to	IN
cord-339752-o6atz33c	32	15	the	the	DT
cord-339752-o6atz33c	32	16	virus	virus	NN
cord-339752-o6atz33c	32	17	.	.	.
cord-339752-o6atz33c	33	1	However	however	RB
cord-339752-o6atz33c	33	2	,	,	,
cord-339752-o6atz33c	33	3	without	without	IN
cord-339752-o6atz33c	33	4	an	an	DT
cord-339752-o6atz33c	33	5	intracellular	intracellular	JJ
cord-339752-o6atz33c	33	6	environment	environment	NN
cord-339752-o6atz33c	33	7	,	,	,
cord-339752-o6atz33c	33	8	the	the	DT
cord-339752-o6atz33c	33	9	virus	virus	NN
cord-339752-o6atz33c	33	10	can	can	MD
cord-339752-o6atz33c	33	11	not	not	RB
cord-339752-o6atz33c	33	12	be	be	VB
cord-339752-o6atz33c	33	13	duplicated	duplicate	VBN
cord-339752-o6atz33c	33	14	.	.	.
cord-339752-o6atz33c	34	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	34	2	is	be	VBZ
cord-339752-o6atz33c	34	3	a	a	DT
cord-339752-o6atz33c	34	4	close	close	JJ
cord-339752-o6atz33c	34	5	homologue	homologue	NN
cord-339752-o6atz33c	34	6	of	of	IN
cord-339752-o6atz33c	34	7	human	human	JJ
cord-339752-o6atz33c	34	8	ACE	ace	NN
cord-339752-o6atz33c	34	9	[	[	-LRB-
cord-339752-o6atz33c	34	10	22	22	CD
cord-339752-o6atz33c	34	11	,	,	,
cord-339752-o6atz33c	34	12	23	23	CD
cord-339752-o6atz33c	34	13	]	]	-RRB-
cord-339752-o6atz33c	34	14	.	.	.
cord-339752-o6atz33c	35	1	As	as	IN
cord-339752-o6atz33c	35	2	is	be	VBZ
cord-339752-o6atz33c	35	3	well	well	RB
cord-339752-o6atz33c	35	4	-	-	HYPH
cord-339752-o6atz33c	35	5	known	know	VBN
cord-339752-o6atz33c	35	6	,	,	,
cord-339752-o6atz33c	35	7	ACE	ACE	NNP
cord-339752-o6atz33c	35	8	cleaves	cleave	VBZ
cord-339752-o6atz33c	35	9	angiotensin	angiotensin	NN
cord-339752-o6atz33c	35	10	I	-PRON-	PRP
cord-339752-o6atz33c	35	11	(	(	-LRB-
cord-339752-o6atz33c	35	12	Ang	Ang	NNP
cord-339752-o6atz33c	35	13	I	I	NNP
cord-339752-o6atz33c	35	14	)	)	-RRB-
cord-339752-o6atz33c	35	15	to	to	IN
cord-339752-o6atz33c	35	16	Ang	Ang	NNP
cord-339752-o6atz33c	35	17	II	II	NNP
cord-339752-o6atz33c	35	18	.	.	.
cord-339752-o6atz33c	36	1	Ang	Ang	NNP
cord-339752-o6atz33c	36	2	II	II	NNP
cord-339752-o6atz33c	36	3	binds	bind	VBZ
cord-339752-o6atz33c	36	4	to	to	IN
cord-339752-o6atz33c	36	5	Ang	Ang	NNP
cord-339752-o6atz33c	36	6	II	II	NNP
cord-339752-o6atz33c	36	7	receptor	receptor	NN
cord-339752-o6atz33c	36	8	1	1	CD
cord-339752-o6atz33c	36	9	(	(	-LRB-
cord-339752-o6atz33c	36	10	AT1	AT1	NNP
cord-339752-o6atz33c	36	11	)	)	-RRB-
cord-339752-o6atz33c	36	12	and	and	CC
cord-339752-o6atz33c	36	13	then	then	RB
cord-339752-o6atz33c	36	14	mediates	mediate	VBZ
cord-339752-o6atz33c	36	15	numerous	numerous	JJ
cord-339752-o6atz33c	36	16	systemic	systemic	JJ
cord-339752-o6atz33c	36	17	and	and	CC
cord-339752-o6atz33c	36	18	local	local	JJ
cord-339752-o6atz33c	36	19	effects	effect	NNS
cord-339752-o6atz33c	36	20	(	(	-LRB-
cord-339752-o6atz33c	36	21	such	such	JJ
cord-339752-o6atz33c	36	22	as	as	IN
cord-339752-o6atz33c	36	23	promoting	promote	VBG
cord-339752-o6atz33c	36	24	vasoconstriction	vasoconstriction	NN
cord-339752-o6atz33c	36	25	,	,	,
cord-339752-o6atz33c	36	26	fibrosis	fibrosis	NN
cord-339752-o6atz33c	36	27	,	,	,
cord-339752-o6atz33c	36	28	and	and	CC
cord-339752-o6atz33c	36	29	salt	salt	NN
cord-339752-o6atz33c	36	30	retention	retention	NN
cord-339752-o6atz33c	36	31	)	)	-RRB-
cord-339752-o6atz33c	36	32	in	in	IN
cord-339752-o6atz33c	36	33	the	the	DT
cord-339752-o6atz33c	36	34	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	36	35	system	system	NN
cord-339752-o6atz33c	37	1	(	(	-LRB-
cord-339752-o6atz33c	37	2	Figure	figure	NN
cord-339752-o6atz33c	37	3	2	2	CD
cord-339752-o6atz33c	37	4	)	)	-RRB-
cord-339752-o6atz33c	37	5	.	.	.
cord-339752-o6atz33c	38	1	In	in	IN
cord-339752-o6atz33c	38	2	the	the	DT
cord-339752-o6atz33c	38	3	RAAS	raa	NNS
cord-339752-o6atz33c	38	4	,	,	,
cord-339752-o6atz33c	38	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	38	6	exerts	exert	VBZ
cord-339752-o6atz33c	38	7	the	the	DT
cord-339752-o6atz33c	38	8	opposite	opposite	JJ
cord-339752-o6atz33c	38	9	role	role	NN
cord-339752-o6atz33c	38	10	of	of	IN
cord-339752-o6atz33c	38	11	ACE	ACE	NNP
cord-339752-o6atz33c	38	12	.	.	.
cord-339752-o6atz33c	39	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	39	2	catalyzes	catalyze	VBZ
cord-339752-o6atz33c	39	3	the	the	DT
cord-339752-o6atz33c	39	4	conversion	conversion	NN
cord-339752-o6atz33c	39	5	of	of	IN
cord-339752-o6atz33c	39	6	Ang	Ang	NNP
cord-339752-o6atz33c	39	7	I	I	NNP
cord-339752-o6atz33c	39	8	to	to	IN
cord-339752-o6atz33c	39	9	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	39	10	-	-	HYPH
cord-339752-o6atz33c	39	11	9	9	CD
cord-339752-o6atz33c	39	12	)	)	-RRB-
cord-339752-o6atz33c	39	13	and	and	CC
cord-339752-o6atz33c	39	14	Ang	Ang	NNP
cord-339752-o6atz33c	39	15	II	II	NNP
cord-339752-o6atz33c	39	16	to	to	IN
cord-339752-o6atz33c	39	17	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	39	18	-	-	HYPH
cord-339752-o6atz33c	39	19	7	7	CD
cord-339752-o6atz33c	39	20	)	)	-RRB-
cord-339752-o6atz33c	39	21	.	.	.
cord-339752-o6atz33c	40	1	The	the	DT
cord-339752-o6atz33c	40	2	converting	convert	VBG
cord-339752-o6atz33c	40	3	efficiency	efficiency	NN
cord-339752-o6atz33c	40	4	of	of	IN
cord-339752-o6atz33c	40	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	40	6	on	on	IN
cord-339752-o6atz33c	40	7	substrate	substrate	JJ
cord-339752-o6atz33c	40	8	Ang	Ang	NNP
cord-339752-o6atz33c	40	9	II	II	NNP
cord-339752-o6atz33c	40	10	is	be	VBZ
cord-339752-o6atz33c	40	11	400-fold	400-fold	CD
cord-339752-o6atz33c	40	12	higher	high	JJR
cord-339752-o6atz33c	40	13	than	than	IN
cord-339752-o6atz33c	40	14	that	that	DT
cord-339752-o6atz33c	40	15	on	on	IN
cord-339752-o6atz33c	40	16	Ang	Ang	NNP
cord-339752-o6atz33c	40	17	I	-PRON-	PRP
cord-339752-o6atz33c	40	18	[	[	-LRB-
cord-339752-o6atz33c	40	19	24	24	CD
cord-339752-o6atz33c	40	20	]	]	-RRB-
cord-339752-o6atz33c	40	21	.	.	.
cord-339752-o6atz33c	41	1	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	41	2	-	-	HYPH
cord-339752-o6atz33c	41	3	7	7	NNP
cord-339752-o6atz33c	41	4	)	)	-RRB-
cord-339752-o6atz33c	41	5	binds	bind	VBZ
cord-339752-o6atz33c	41	6	to	to	IN
cord-339752-o6atz33c	41	7	the	the	DT
cord-339752-o6atz33c	41	8	G	g	NN
cord-339752-o6atz33c	41	9	protein	protein	NN
cord-339752-o6atz33c	41	10	-	-	HYPH
cord-339752-o6atz33c	41	11	coupled	couple	VBN
cord-339752-o6atz33c	41	12	receptor	receptor	NN
cord-339752-o6atz33c	41	13	Mas	Mas	NNP
cord-339752-o6atz33c	41	14	to	to	TO
cord-339752-o6atz33c	41	15	mediate	mediate	VB
cord-339752-o6atz33c	41	16	various	various	JJ
cord-339752-o6atz33c	41	17	effects	effect	NNS
cord-339752-o6atz33c	41	18	including	include	VBG
cord-339752-o6atz33c	41	19	vasorelaxation	vasorelaxation	NN
cord-339752-o6atz33c	41	20	,	,	,
cord-339752-o6atz33c	41	21	cardioprotection	cardioprotection	NN
cord-339752-o6atz33c	41	22	,	,	,
cord-339752-o6atz33c	41	23	anti	anti	JJ
cord-339752-o6atz33c	41	24	-	-	JJ
cord-339752-o6atz33c	41	25	oxidative	oxidative	JJ
cord-339752-o6atz33c	41	26	action	action	NN
cord-339752-o6atz33c	41	27	[	[	-LRB-
cord-339752-o6atz33c	41	28	25	25	CD
cord-339752-o6atz33c	41	29	]	]	-RRB-
cord-339752-o6atz33c	41	30	,	,	,
cord-339752-o6atz33c	41	31	antiinflammation	antiinflammation	NN
cord-339752-o6atz33c	41	32	[	[	-LRB-
cord-339752-o6atz33c	41	33	26	26	CD
cord-339752-o6atz33c	41	34	]	]	-RRB-
cord-339752-o6atz33c	41	35	,	,	,
cord-339752-o6atz33c	41	36	and	and	CC
cord-339752-o6atz33c	41	37	the	the	DT
cord-339752-o6atz33c	41	38	inhibition	inhibition	NN
cord-339752-o6atz33c	41	39	of	of	IN
cord-339752-o6atz33c	41	40	Ang	Ang	NNP
cord-339752-o6atz33c	41	41	II	II	NNP
cord-339752-o6atz33c	41	42	-	-	HYPH
cord-339752-o6atz33c	41	43	induced	induce	VBN
cord-339752-o6atz33c	41	44	signaling	signal	VBG
cord-339752-o6atz33c	41	45	[	[	-LRB-
cord-339752-o6atz33c	41	46	27	27	CD
cord-339752-o6atz33c	41	47	,	,	,
cord-339752-o6atz33c	41	48	28	28	CD
cord-339752-o6atz33c	41	49	]	]	-RRB-
cord-339752-o6atz33c	41	50	.	.	.
cord-339752-o6atz33c	42	1	The	the	DT
cord-339752-o6atz33c	42	2	ACE2-Ang-(1	ACE2-Ang-(1	NNP
cord-339752-o6atz33c	42	3	-	-	HYPH
cord-339752-o6atz33c	42	4	7	7	CD
cord-339752-o6atz33c	42	5	)	)	-RRB-
cord-339752-o6atz33c	42	6	axis	axis	NN
cord-339752-o6atz33c	42	7	is	be	VBZ
cord-339752-o6atz33c	42	8	considered	consider	VBN
cord-339752-o6atz33c	42	9	an	an	DT
cord-339752-o6atz33c	42	10	important	important	JJ
cord-339752-o6atz33c	42	11	therapeutic	therapeutic	JJ
cord-339752-o6atz33c	42	12	target	target	NN
cord-339752-o6atz33c	42	13	in	in	IN
cord-339752-o6atz33c	42	14	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	42	15	disorders	disorder	NNS
cord-339752-o6atz33c	42	16	[	[	-LRB-
cord-339752-o6atz33c	42	17	29	29	CD
cord-339752-o6atz33c	42	18	]	]	-RRB-
cord-339752-o6atz33c	42	19	.	.	.
cord-339752-o6atz33c	43	1	A	a	DT
cord-339752-o6atz33c	43	2	large	large	JJ
cord-339752-o6atz33c	43	3	cohort	cohort	NN
cord-339752-o6atz33c	43	4	study	study	NN
cord-339752-o6atz33c	43	5	showed	show	VBD
cord-339752-o6atz33c	43	6	that	that	IN
cord-339752-o6atz33c	43	7	circulating	circulate	VBG
cord-339752-o6atz33c	43	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	43	9	was	be	VBD
cord-339752-o6atz33c	43	10	only	only	RB
cord-339752-o6atz33c	43	11	detectable	detectable	JJ
cord-339752-o6atz33c	43	12	in	in	IN
cord-339752-o6atz33c	43	13	the	the	DT
cord-339752-o6atz33c	43	14	serum	serum	NN
cord-339752-o6atz33c	43	15	of	of	IN
cord-339752-o6atz33c	43	16	40	40	CD
cord-339752-o6atz33c	43	17	among	among	IN
cord-339752-o6atz33c	43	18	534	534	CD
cord-339752-o6atz33c	43	19	test	test	NN
cord-339752-o6atz33c	43	20	subjects	subject	NNS
cord-339752-o6atz33c	43	21	,	,	,
cord-339752-o6atz33c	43	22	and	and	CC
cord-339752-o6atz33c	43	23	its	-PRON-	PRP$
cord-339752-o6atz33c	43	24	concentration	concentration	NN
cord-339752-o6atz33c	43	25	was	be	VBD
cord-339752-o6atz33c	43	26	approximately	approximately	RB
cord-339752-o6atz33c	43	27	100-fold	100-fold	CD
cord-339752-o6atz33c	43	28	lower	low	JJR
cord-339752-o6atz33c	43	29	than	than	IN
cord-339752-o6atz33c	43	30	that	that	DT
cord-339752-o6atz33c	43	31	of	of	IN
cord-339752-o6atz33c	43	32	circulating	circulate	VBG
cord-339752-o6atz33c	43	33	ACE	ace	NN
cord-339752-o6atz33c	43	34	[	[	-LRB-
cord-339752-o6atz33c	43	35	30	30	CD
cord-339752-o6atz33c	43	36	]	]	-RRB-
cord-339752-o6atz33c	43	37	.	.	.
cord-339752-o6atz33c	44	1	More	More	JJR
cord-339752-o6atz33c	44	2	evidence	evidence	NN
cord-339752-o6atz33c	44	3	showed	show	VBD
cord-339752-o6atz33c	44	4	that	that	IN
cord-339752-o6atz33c	44	5	circulating	circulate	VBG
cord-339752-o6atz33c	44	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	44	7	is	be	VBZ
cord-339752-o6atz33c	44	8	increased	increase	VBN
cord-339752-o6atz33c	44	9	in	in	IN
cord-339752-o6atz33c	44	10	patients	patient	NNS
cord-339752-o6atz33c	44	11	with	with	IN
cord-339752-o6atz33c	44	12	type	type	NN
cord-339752-o6atz33c	44	13	1	1	CD
cord-339752-o6atz33c	44	14	or	or	CC
cord-339752-o6atz33c	44	15	type	type	NN
cord-339752-o6atz33c	44	16	2	2	CD
cord-339752-o6atz33c	44	17	diabetes	diabetes	NN
cord-339752-o6atz33c	44	18	,	,	,
cord-339752-o6atz33c	44	19	hypertension	hypertension	NN
cord-339752-o6atz33c	44	20	,	,	,
cord-339752-o6atz33c	44	21	heart	heart	NN
cord-339752-o6atz33c	44	22	failure	failure	NN
cord-339752-o6atz33c	44	23	,	,	,
cord-339752-o6atz33c	44	24	and	and	CC
cord-339752-o6atz33c	44	25	chronic	chronic	JJ
cord-339752-o6atz33c	44	26	kidney	kidney	NN
cord-339752-o6atz33c	44	27	diseases	disease	NNS
cord-339752-o6atz33c	44	28	[	[	-LRB-
cord-339752-o6atz33c	44	29	31	31	CD
cord-339752-o6atz33c	44	30	]	]	-RRB-
cord-339752-o6atz33c	44	31	[	[	-LRB-
cord-339752-o6atz33c	44	32	32	32	CD
cord-339752-o6atz33c	44	33	]	]	-RRB-
cord-339752-o6atz33c	44	34	[	[	-LRB-
cord-339752-o6atz33c	44	35	33	33	CD
cord-339752-o6atz33c	44	36	]	]	-RRB-
cord-339752-o6atz33c	44	37	.	.	.
cord-339752-o6atz33c	45	1	The	the	DT
cord-339752-o6atz33c	45	2	reason	reason	NN
cord-339752-o6atz33c	45	3	for	for	IN
cord-339752-o6atz33c	45	4	high	high	JJ
cord-339752-o6atz33c	45	5	levels	level	NNS
cord-339752-o6atz33c	45	6	of	of	IN
cord-339752-o6atz33c	45	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	45	8	in	in	IN
cord-339752-o6atz33c	45	9	these	these	DT
cord-339752-o6atz33c	45	10	patients	patient	NNS
cord-339752-o6atz33c	45	11	is	be	VBZ
cord-339752-o6atz33c	45	12	that	that	DT
cord-339752-o6atz33c	45	13	increased	increase	VBN
cord-339752-o6atz33c	45	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	45	15	is	be	VBZ
cord-339752-o6atz33c	45	16	a	a	DT
cord-339752-o6atz33c	45	17	defensive	defensive	JJ
cord-339752-o6atz33c	45	18	response	response	NN
cord-339752-o6atz33c	45	19	to	to	TO
cord-339752-o6atz33c	45	20	counteract	counteract	VB
cord-339752-o6atz33c	45	21	the	the	DT
cord-339752-o6atz33c	45	22	adverse	adverse	JJ
cord-339752-o6atz33c	45	23	effect	effect	NN
cord-339752-o6atz33c	45	24	of	of	IN
cord-339752-o6atz33c	45	25	Ang	Ang	NNP
cord-339752-o6atz33c	45	26	II	II	NNP
cord-339752-o6atz33c	45	27	.	.	.
cord-339752-o6atz33c	46	1	Since	since	IN
cord-339752-o6atz33c	46	2	Ang	Ang	NNP
cord-339752-o6atz33c	46	3	II	II	NNP
cord-339752-o6atz33c	46	4	-	-	HYPH
cord-339752-o6atz33c	46	5	AT1	at1	NN
cord-339752-o6atz33c	46	6	receptor	receptor	NN
cord-339752-o6atz33c	46	7	signaling	signaling	NN
cord-339752-o6atz33c	46	8	also	also	RB
cord-339752-o6atz33c	46	9	promotes	promote	VBZ
cord-339752-o6atz33c	46	10	autoimmune	autoimmune	JJ
cord-339752-o6atz33c	46	11	response	response	NN
cord-339752-o6atz33c	46	12	,	,	,
cord-339752-o6atz33c	46	13	ACE2	ACE2	NNP
cord-339752-o6atz33c	46	14	may	may	MD
cord-339752-o6atz33c	46	15	control	control	VB
cord-339752-o6atz33c	46	16	immune	immune	JJ
cord-339752-o6atz33c	46	17	functions	function	NNS
cord-339752-o6atz33c	46	18	through	through	IN
cord-339752-o6atz33c	46	19	the	the	DT
cord-339752-o6atz33c	46	20	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	46	21	-	-	HYPH
cord-339752-o6atz33c	46	22	7)-Mas	7)-mas	CD
cord-339752-o6atz33c	46	23	axis	axis	NN
cord-339752-o6atz33c	46	24	[	[	-LRB-
cord-339752-o6atz33c	46	25	34	34	CD
cord-339752-o6atz33c	46	26	,	,	,
cord-339752-o6atz33c	46	27	35	35	CD
cord-339752-o6atz33c	46	28	]	]	-RRB-
cord-339752-o6atz33c	46	29	.	.	.
cord-339752-o6atz33c	47	1	Cellular	Cellular	NNP
cord-339752-o6atz33c	47	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	47	3	,	,	,
cord-339752-o6atz33c	47	4	ADAM17	adam17	UH
cord-339752-o6atz33c	47	5	,	,	,
cord-339752-o6atz33c	47	6	and	and	CC
cord-339752-o6atz33c	47	7	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	47	8	are	be	VBP
cord-339752-o6atz33c	47	9	all	all	DT
cord-339752-o6atz33c	47	10	expressed	express	VBN
cord-339752-o6atz33c	47	11	on	on	IN
cord-339752-o6atz33c	47	12	the	the	DT
cord-339752-o6atz33c	47	13	cell	cell	NN
cord-339752-o6atz33c	47	14	membrane	membrane	NN
cord-339752-o6atz33c	47	15	.	.	.
cord-339752-o6atz33c	48	1	After	after	IN
cord-339752-o6atz33c	48	2	being	be	VBG
cord-339752-o6atz33c	48	3	shed	shed	VBN
cord-339752-o6atz33c	48	4	by	by	IN
cord-339752-o6atz33c	48	5	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	48	6	,	,	,
cord-339752-o6atz33c	48	7	soluble	soluble	JJ
cord-339752-o6atz33c	48	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	48	9	is	be	VBZ
cord-339752-o6atz33c	48	10	released	release	VBN
cord-339752-o6atz33c	48	11	from	from	IN
cord-339752-o6atz33c	48	12	its	-PRON-	PRP$
cord-339752-o6atz33c	48	13	full	full	JJ
cord-339752-o6atz33c	48	14	-	-	HYPH
cord-339752-o6atz33c	48	15	length	length	NN
cord-339752-o6atz33c	48	16	form	form	NN
cord-339752-o6atz33c	48	17	to	to	TO
cord-339752-o6atz33c	48	18	counteract	counteract	VB
cord-339752-o6atz33c	48	19	the	the	DT
cord-339752-o6atz33c	48	20	effects	effect	NNS
cord-339752-o6atz33c	48	21	of	of	IN
cord-339752-o6atz33c	48	22	Ang	Ang	NNP
cord-339752-o6atz33c	48	23	II	II	NNP
cord-339752-o6atz33c	48	24	signaling	signal	VBG
cord-339752-o6atz33c	48	25	.	.	.
cord-339752-o6atz33c	49	1	Alternatively	alternatively	RB
cord-339752-o6atz33c	49	2	,	,	,
cord-339752-o6atz33c	49	3	cellular	cellular	JJ
cord-339752-o6atz33c	49	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	49	5	is	be	VBZ
cord-339752-o6atz33c	49	6	also	also	RB
cord-339752-o6atz33c	49	7	shed	shed	VBN
cord-339752-o6atz33c	49	8	by	by	IN
cord-339752-o6atz33c	49	9	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	49	10	,	,	,
cord-339752-o6atz33c	49	11	which	which	WDT
cord-339752-o6atz33c	49	12	results	result	VBZ
cord-339752-o6atz33c	49	13	in	in	IN
cord-339752-o6atz33c	49	14	SARS	SARS	NNP
cord-339752-o6atz33c	49	15	-	-	HYPH
cord-339752-o6atz33c	49	16	CoV-2-cell	CoV-2-cell	NNP
cord-339752-o6atz33c	49	17	membrane	membrane	NN
cord-339752-o6atz33c	49	18	fusion	fusion	NN
cord-339752-o6atz33c	49	19	.	.	.
cord-339752-o6atz33c	50	1	SARS	SARS	NNP
cord-339752-o6atz33c	50	2	-	-	HYPH
cord-339752-o6atz33c	50	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	50	4	RNA	RNA	NNP
cord-339752-o6atz33c	50	5	is	be	VBZ
cord-339752-o6atz33c	50	6	then	then	RB
cord-339752-o6atz33c	50	7	released	release	VBN
cord-339752-o6atz33c	50	8	into	into	IN
cord-339752-o6atz33c	50	9	the	the	DT
cord-339752-o6atz33c	50	10	cytoplasm	cytoplasm	NN
cord-339752-o6atz33c	50	11	and	and	CC
cord-339752-o6atz33c	50	12	viral	viral	JJ
cord-339752-o6atz33c	50	13	replication	replication	NN
cord-339752-o6atz33c	50	14	is	be	VBZ
cord-339752-o6atz33c	50	15	efficiently	efficiently	RB
cord-339752-o6atz33c	50	16	processed	process	VBN
cord-339752-o6atz33c	50	17	.	.	.
cord-339752-o6atz33c	51	1	Because	because	IN
cord-339752-o6atz33c	51	2	soluble	soluble	JJ
cord-339752-o6atz33c	51	3	ACE2	ACE2	NNP
cord-339752-o6atz33c	51	4	contains	contain	VBZ
cord-339752-o6atz33c	51	5	the	the	DT
cord-339752-o6atz33c	51	6	virus	virus	NN
cord-339752-o6atz33c	51	7	binding	bind	VBG
cord-339752-o6atz33c	51	8	site	site	NN
cord-339752-o6atz33c	51	9	,	,	,
cord-339752-o6atz33c	51	10	it	-PRON-	PRP
cord-339752-o6atz33c	51	11	can	can	MD
cord-339752-o6atz33c	51	12	also	also	RB
cord-339752-o6atz33c	51	13	bind	bind	VB
cord-339752-o6atz33c	51	14	to	to	IN
cord-339752-o6atz33c	51	15	the	the	DT
cord-339752-o6atz33c	51	16	virus	virus	NN
cord-339752-o6atz33c	51	17	.	.	.
cord-339752-o6atz33c	52	1	However	however	RB
cord-339752-o6atz33c	52	2	,	,	,
cord-339752-o6atz33c	52	3	without	without	IN
cord-339752-o6atz33c	52	4	an	an	DT
cord-339752-o6atz33c	52	5	intracellular	intracellular	JJ
cord-339752-o6atz33c	52	6	environment	environment	NN
cord-339752-o6atz33c	52	7	,	,	,
cord-339752-o6atz33c	52	8	the	the	DT
cord-339752-o6atz33c	52	9	virus	virus	NN
cord-339752-o6atz33c	52	10	can	can	MD
cord-339752-o6atz33c	52	11	not	not	RB
cord-339752-o6atz33c	52	12	be	be	VB
cord-339752-o6atz33c	52	13	duplicated	duplicate	VBN
cord-339752-o6atz33c	52	14	.	.	.
cord-339752-o6atz33c	53	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	53	2	is	be	VBZ
cord-339752-o6atz33c	53	3	a	a	DT
cord-339752-o6atz33c	53	4	close	close	JJ
cord-339752-o6atz33c	53	5	homologue	homologue	NN
cord-339752-o6atz33c	53	6	of	of	IN
cord-339752-o6atz33c	53	7	human	human	JJ
cord-339752-o6atz33c	53	8	ACE	ace	NN
cord-339752-o6atz33c	53	9	[	[	-LRB-
cord-339752-o6atz33c	53	10	22	22	CD
cord-339752-o6atz33c	53	11	,	,	,
cord-339752-o6atz33c	53	12	23	23	CD
cord-339752-o6atz33c	53	13	]	]	-RRB-
cord-339752-o6atz33c	53	14	.	.	.
cord-339752-o6atz33c	54	1	As	as	IN
cord-339752-o6atz33c	54	2	is	be	VBZ
cord-339752-o6atz33c	54	3	well	well	RB
cord-339752-o6atz33c	54	4	-	-	HYPH
cord-339752-o6atz33c	54	5	known	know	VBN
cord-339752-o6atz33c	54	6	,	,	,
cord-339752-o6atz33c	54	7	ACE	ACE	NNP
cord-339752-o6atz33c	54	8	cleaves	cleave	VBZ
cord-339752-o6atz33c	54	9	angiotensin	angiotensin	NN
cord-339752-o6atz33c	54	10	I	-PRON-	PRP
cord-339752-o6atz33c	54	11	(	(	-LRB-
cord-339752-o6atz33c	54	12	Ang	Ang	NNP
cord-339752-o6atz33c	54	13	I	I	NNP
cord-339752-o6atz33c	54	14	)	)	-RRB-
cord-339752-o6atz33c	54	15	to	to	IN
cord-339752-o6atz33c	54	16	Ang	Ang	NNP
cord-339752-o6atz33c	54	17	II	II	NNP
cord-339752-o6atz33c	54	18	.	.	.
cord-339752-o6atz33c	55	1	Ang	Ang	NNP
cord-339752-o6atz33c	55	2	II	II	NNP
cord-339752-o6atz33c	55	3	binds	bind	VBZ
cord-339752-o6atz33c	55	4	to	to	IN
cord-339752-o6atz33c	55	5	Ang	Ang	NNP
cord-339752-o6atz33c	55	6	II	II	NNP
cord-339752-o6atz33c	55	7	receptor	receptor	NN
cord-339752-o6atz33c	55	8	1	1	CD
cord-339752-o6atz33c	55	9	(	(	-LRB-
cord-339752-o6atz33c	56	1	AT	at	IN
cord-339752-o6atz33c	56	2	1	1	CD
cord-339752-o6atz33c	56	3	)	)	-RRB-
cord-339752-o6atz33c	56	4	and	and	CC
cord-339752-o6atz33c	56	5	then	then	RB
cord-339752-o6atz33c	56	6	mediates	mediate	VBZ
cord-339752-o6atz33c	56	7	numerous	numerous	JJ
cord-339752-o6atz33c	56	8	systemic	systemic	JJ
cord-339752-o6atz33c	56	9	and	and	CC
cord-339752-o6atz33c	56	10	local	local	JJ
cord-339752-o6atz33c	56	11	effects	effect	NNS
cord-339752-o6atz33c	56	12	(	(	-LRB-
cord-339752-o6atz33c	56	13	such	such	JJ
cord-339752-o6atz33c	56	14	as	as	IN
cord-339752-o6atz33c	56	15	promoting	promote	VBG
cord-339752-o6atz33c	56	16	vasoconstriction	vasoconstriction	NN
cord-339752-o6atz33c	56	17	,	,	,
cord-339752-o6atz33c	56	18	fibrosis	fibrosis	NN
cord-339752-o6atz33c	56	19	,	,	,
cord-339752-o6atz33c	56	20	and	and	CC
cord-339752-o6atz33c	56	21	salt	salt	NN
cord-339752-o6atz33c	56	22	retention	retention	NN
cord-339752-o6atz33c	56	23	)	)	-RRB-
cord-339752-o6atz33c	56	24	in	in	IN
cord-339752-o6atz33c	56	25	the	the	DT
cord-339752-o6atz33c	56	26	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	56	27	system	system	NN
cord-339752-o6atz33c	57	1	(	(	-LRB-
cord-339752-o6atz33c	57	2	Figure	figure	NN
cord-339752-o6atz33c	57	3	2	2	CD
cord-339752-o6atz33c	57	4	)	)	-RRB-
cord-339752-o6atz33c	57	5	.	.	.
cord-339752-o6atz33c	58	1	In	in	IN
cord-339752-o6atz33c	58	2	the	the	DT
cord-339752-o6atz33c	58	3	RAAS	raa	NNS
cord-339752-o6atz33c	58	4	,	,	,
cord-339752-o6atz33c	58	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	58	6	exerts	exert	VBZ
cord-339752-o6atz33c	58	7	the	the	DT
cord-339752-o6atz33c	58	8	opposite	opposite	JJ
cord-339752-o6atz33c	58	9	role	role	NN
cord-339752-o6atz33c	58	10	of	of	IN
cord-339752-o6atz33c	58	11	ACE	ACE	NNP
cord-339752-o6atz33c	58	12	.	.	.
cord-339752-o6atz33c	59	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	59	2	catalyzes	catalyze	VBZ
cord-339752-o6atz33c	59	3	the	the	DT
cord-339752-o6atz33c	59	4	conversion	conversion	NN
cord-339752-o6atz33c	59	5	of	of	IN
cord-339752-o6atz33c	59	6	Ang	Ang	NNP
cord-339752-o6atz33c	59	7	I	I	NNP
cord-339752-o6atz33c	59	8	to	to	IN
cord-339752-o6atz33c	59	9	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	59	10	-	-	HYPH
cord-339752-o6atz33c	59	11	9	9	CD
cord-339752-o6atz33c	59	12	)	)	-RRB-
cord-339752-o6atz33c	59	13	and	and	CC
cord-339752-o6atz33c	59	14	Ang	Ang	NNP
cord-339752-o6atz33c	59	15	II	II	NNP
cord-339752-o6atz33c	59	16	to	to	IN
cord-339752-o6atz33c	59	17	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	59	18	-	-	HYPH
cord-339752-o6atz33c	59	19	7	7	CD
cord-339752-o6atz33c	59	20	)	)	-RRB-
cord-339752-o6atz33c	59	21	.	.	.
cord-339752-o6atz33c	60	1	The	the	DT
cord-339752-o6atz33c	60	2	converting	convert	VBG
cord-339752-o6atz33c	60	3	efficiency	efficiency	NN
cord-339752-o6atz33c	60	4	of	of	IN
cord-339752-o6atz33c	60	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	60	6	on	on	IN
cord-339752-o6atz33c	60	7	substrate	substrate	JJ
cord-339752-o6atz33c	60	8	Ang	Ang	NNP
cord-339752-o6atz33c	60	9	II	II	NNP
cord-339752-o6atz33c	60	10	is	be	VBZ
cord-339752-o6atz33c	60	11	400-fold	400-fold	CD
cord-339752-o6atz33c	60	12	higher	high	JJR
cord-339752-o6atz33c	60	13	than	than	IN
cord-339752-o6atz33c	60	14	that	that	DT
cord-339752-o6atz33c	60	15	on	on	IN
cord-339752-o6atz33c	60	16	Ang	Ang	NNP
cord-339752-o6atz33c	60	17	I	-PRON-	PRP
cord-339752-o6atz33c	60	18	[	[	-LRB-
cord-339752-o6atz33c	60	19	24	24	CD
cord-339752-o6atz33c	60	20	]	]	-RRB-
cord-339752-o6atz33c	60	21	.	.	.
cord-339752-o6atz33c	61	1	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	61	2	-	-	HYPH
cord-339752-o6atz33c	61	3	7	7	NNP
cord-339752-o6atz33c	61	4	)	)	-RRB-
cord-339752-o6atz33c	61	5	binds	bind	VBZ
cord-339752-o6atz33c	61	6	to	to	IN
cord-339752-o6atz33c	61	7	the	the	DT
cord-339752-o6atz33c	61	8	G	g	NN
cord-339752-o6atz33c	61	9	protein	protein	NN
cord-339752-o6atz33c	61	10	-	-	HYPH
cord-339752-o6atz33c	61	11	coupled	couple	VBN
cord-339752-o6atz33c	61	12	receptor	receptor	NN
cord-339752-o6atz33c	61	13	Mas	Mas	NNP
cord-339752-o6atz33c	61	14	to	to	TO
cord-339752-o6atz33c	61	15	mediate	mediate	VB
cord-339752-o6atz33c	61	16	various	various	JJ
cord-339752-o6atz33c	61	17	effects	effect	NNS
cord-339752-o6atz33c	61	18	including	include	VBG
cord-339752-o6atz33c	61	19	vasorelaxation	vasorelaxation	NN
cord-339752-o6atz33c	61	20	,	,	,
cord-339752-o6atz33c	61	21	cardioprotection	cardioprotection	NN
cord-339752-o6atz33c	61	22	,	,	,
cord-339752-o6atz33c	61	23	anti	anti	JJ
cord-339752-o6atz33c	61	24	-	-	JJ
cord-339752-o6atz33c	61	25	oxidative	oxidative	JJ
cord-339752-o6atz33c	61	26	action	action	NN
cord-339752-o6atz33c	61	27	[	[	-LRB-
cord-339752-o6atz33c	61	28	25	25	CD
cord-339752-o6atz33c	61	29	]	]	-RRB-
cord-339752-o6atz33c	61	30	,	,	,
cord-339752-o6atz33c	61	31	anti	anti	JJ
cord-339752-o6atz33c	61	32	-	-	JJ
cord-339752-o6atz33c	61	33	inflammation	inflammation	JJ
cord-339752-o6atz33c	61	34	[	[	-LRB-
cord-339752-o6atz33c	61	35	26	26	CD
cord-339752-o6atz33c	61	36	]	]	-RRB-
cord-339752-o6atz33c	61	37	,	,	,
cord-339752-o6atz33c	61	38	and	and	CC
cord-339752-o6atz33c	61	39	the	the	DT
cord-339752-o6atz33c	61	40	inhibition	inhibition	NN
cord-339752-o6atz33c	61	41	of	of	IN
cord-339752-o6atz33c	61	42	Ang	Ang	NNP
cord-339752-o6atz33c	61	43	II	II	NNP
cord-339752-o6atz33c	61	44	-	-	HYPH
cord-339752-o6atz33c	61	45	induced	induce	VBN
cord-339752-o6atz33c	61	46	signaling	signal	VBG
cord-339752-o6atz33c	61	47	[	[	-LRB-
cord-339752-o6atz33c	61	48	27	27	CD
cord-339752-o6atz33c	61	49	,	,	,
cord-339752-o6atz33c	61	50	28	28	CD
cord-339752-o6atz33c	61	51	]	]	-RRB-
cord-339752-o6atz33c	61	52	.	.	.
cord-339752-o6atz33c	62	1	The	the	DT
cord-339752-o6atz33c	62	2	ACE2-Ang-(1	ACE2-Ang-(1	NNP
cord-339752-o6atz33c	62	3	-	-	HYPH
cord-339752-o6atz33c	62	4	7	7	CD
cord-339752-o6atz33c	62	5	)	)	-RRB-
cord-339752-o6atz33c	62	6	axis	axis	NN
cord-339752-o6atz33c	62	7	is	be	VBZ
cord-339752-o6atz33c	62	8	considered	consider	VBN
cord-339752-o6atz33c	62	9	an	an	DT
cord-339752-o6atz33c	62	10	important	important	JJ
cord-339752-o6atz33c	62	11	therapeutic	therapeutic	JJ
cord-339752-o6atz33c	62	12	target	target	NN
cord-339752-o6atz33c	62	13	in	in	IN
cord-339752-o6atz33c	62	14	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	62	15	disorders	disorder	NNS
cord-339752-o6atz33c	62	16	[	[	-LRB-
cord-339752-o6atz33c	62	17	29	29	CD
cord-339752-o6atz33c	62	18	]	]	-RRB-
cord-339752-o6atz33c	62	19	.	.	.
cord-339752-o6atz33c	63	1	A	a	DT
cord-339752-o6atz33c	63	2	large	large	JJ
cord-339752-o6atz33c	63	3	cohort	cohort	NN
cord-339752-o6atz33c	63	4	study	study	NN
cord-339752-o6atz33c	63	5	showed	show	VBD
cord-339752-o6atz33c	63	6	that	that	IN
cord-339752-o6atz33c	63	7	circulating	circulate	VBG
cord-339752-o6atz33c	63	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	63	9	was	be	VBD
cord-339752-o6atz33c	63	10	only	only	RB
cord-339752-o6atz33c	63	11	detectable	detectable	JJ
cord-339752-o6atz33c	63	12	in	in	IN
cord-339752-o6atz33c	63	13	the	the	DT
cord-339752-o6atz33c	63	14	serum	serum	NN
cord-339752-o6atz33c	63	15	of	of	IN
cord-339752-o6atz33c	63	16	40	40	CD
cord-339752-o6atz33c	63	17	among	among	IN
cord-339752-o6atz33c	63	18	534	534	CD
cord-339752-o6atz33c	63	19	test	test	NN
cord-339752-o6atz33c	63	20	subjects	subject	NNS
cord-339752-o6atz33c	63	21	,	,	,
cord-339752-o6atz33c	63	22	and	and	CC
cord-339752-o6atz33c	63	23	its	-PRON-	PRP$
cord-339752-o6atz33c	63	24	concentration	concentration	NN
cord-339752-o6atz33c	63	25	was	be	VBD
cord-339752-o6atz33c	63	26	approximately	approximately	RB
cord-339752-o6atz33c	63	27	100-fold	100-fold	CD
cord-339752-o6atz33c	63	28	lower	low	JJR
cord-339752-o6atz33c	63	29	than	than	IN
cord-339752-o6atz33c	63	30	that	that	DT
cord-339752-o6atz33c	63	31	of	of	IN
cord-339752-o6atz33c	63	32	circulating	circulate	VBG
cord-339752-o6atz33c	63	33	ACE	ace	NN
cord-339752-o6atz33c	63	34	[	[	-LRB-
cord-339752-o6atz33c	63	35	30	30	CD
cord-339752-o6atz33c	63	36	]	]	-RRB-
cord-339752-o6atz33c	63	37	.	.	.
cord-339752-o6atz33c	64	1	More	More	JJR
cord-339752-o6atz33c	64	2	evidence	evidence	NN
cord-339752-o6atz33c	64	3	showed	show	VBD
cord-339752-o6atz33c	64	4	that	that	IN
cord-339752-o6atz33c	64	5	circulating	circulate	VBG
cord-339752-o6atz33c	64	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	64	7	is	be	VBZ
cord-339752-o6atz33c	64	8	increased	increase	VBN
cord-339752-o6atz33c	64	9	in	in	IN
cord-339752-o6atz33c	64	10	patients	patient	NNS
cord-339752-o6atz33c	64	11	with	with	IN
cord-339752-o6atz33c	64	12	type	type	NN
cord-339752-o6atz33c	64	13	1	1	CD
cord-339752-o6atz33c	64	14	or	or	CC
cord-339752-o6atz33c	64	15	type	type	NN
cord-339752-o6atz33c	64	16	2	2	CD
cord-339752-o6atz33c	64	17	diabetes	diabetes	NN
cord-339752-o6atz33c	64	18	,	,	,
cord-339752-o6atz33c	64	19	hypertension	hypertension	NN
cord-339752-o6atz33c	64	20	,	,	,
cord-339752-o6atz33c	64	21	heart	heart	NN
cord-339752-o6atz33c	64	22	failure	failure	NN
cord-339752-o6atz33c	64	23	,	,	,
cord-339752-o6atz33c	64	24	and	and	CC
cord-339752-o6atz33c	64	25	chronic	chronic	JJ
cord-339752-o6atz33c	64	26	kidney	kidney	NN
cord-339752-o6atz33c	64	27	diseases	disease	NNS
cord-339752-o6atz33c	64	28	[	[	-LRB-
cord-339752-o6atz33c	64	29	31	31	CD
cord-339752-o6atz33c	64	30	]	]	-RRB-
cord-339752-o6atz33c	64	31	[	[	-LRB-
cord-339752-o6atz33c	64	32	32	32	CD
cord-339752-o6atz33c	64	33	]	]	-RRB-
cord-339752-o6atz33c	64	34	[	[	-LRB-
cord-339752-o6atz33c	64	35	33	33	CD
cord-339752-o6atz33c	64	36	]	]	-RRB-
cord-339752-o6atz33c	64	37	.	.	.
cord-339752-o6atz33c	65	1	The	the	DT
cord-339752-o6atz33c	65	2	reason	reason	NN
cord-339752-o6atz33c	65	3	for	for	IN
cord-339752-o6atz33c	65	4	high	high	JJ
cord-339752-o6atz33c	65	5	levels	level	NNS
cord-339752-o6atz33c	65	6	of	of	IN
cord-339752-o6atz33c	65	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	65	8	in	in	IN
cord-339752-o6atz33c	65	9	these	these	DT
cord-339752-o6atz33c	65	10	patients	patient	NNS
cord-339752-o6atz33c	65	11	is	be	VBZ
cord-339752-o6atz33c	65	12	that	that	DT
cord-339752-o6atz33c	65	13	increased	increase	VBN
cord-339752-o6atz33c	65	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	65	15	is	be	VBZ
cord-339752-o6atz33c	65	16	a	a	DT
cord-339752-o6atz33c	65	17	defensive	defensive	JJ
cord-339752-o6atz33c	65	18	response	response	NN
cord-339752-o6atz33c	65	19	to	to	TO
cord-339752-o6atz33c	65	20	counteract	counteract	VB
cord-339752-o6atz33c	65	21	the	the	DT
cord-339752-o6atz33c	65	22	adverse	adverse	JJ
cord-339752-o6atz33c	65	23	effect	effect	NN
cord-339752-o6atz33c	65	24	of	of	IN
cord-339752-o6atz33c	65	25	Ang	Ang	NNP
cord-339752-o6atz33c	65	26	II	II	NNP
cord-339752-o6atz33c	65	27	.	.	.
cord-339752-o6atz33c	66	1	Since	since	IN
cord-339752-o6atz33c	66	2	Ang	Ang	NNP
cord-339752-o6atz33c	66	3	II	II	NNP
cord-339752-o6atz33c	66	4	-	-	HYPH
cord-339752-o6atz33c	66	5	AT	at	NN
cord-339752-o6atz33c	66	6	1	1	CD
cord-339752-o6atz33c	66	7	receptor	receptor	NN
cord-339752-o6atz33c	66	8	signaling	signaling	NN
cord-339752-o6atz33c	66	9	also	also	RB
cord-339752-o6atz33c	66	10	promotes	promote	VBZ
cord-339752-o6atz33c	66	11	autoimmune	autoimmune	JJ
cord-339752-o6atz33c	66	12	response	response	NN
cord-339752-o6atz33c	66	13	,	,	,
cord-339752-o6atz33c	66	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	66	15	may	may	MD
cord-339752-o6atz33c	66	16	control	control	VB
cord-339752-o6atz33c	66	17	immune	immune	JJ
cord-339752-o6atz33c	66	18	functions	function	NNS
cord-339752-o6atz33c	66	19	through	through	IN
cord-339752-o6atz33c	66	20	the	the	DT
cord-339752-o6atz33c	66	21	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	66	22	-	-	HYPH
cord-339752-o6atz33c	66	23	7)-Mas	7)-mas	CD
cord-339752-o6atz33c	66	24	axis	axis	NN
cord-339752-o6atz33c	66	25	[	[	-LRB-
cord-339752-o6atz33c	66	26	34	34	CD
cord-339752-o6atz33c	66	27	,	,	,
cord-339752-o6atz33c	66	28	35	35	CD
cord-339752-o6atz33c	66	29	]	]	-RRB-
cord-339752-o6atz33c	66	30	.	.	.
cord-339752-o6atz33c	67	1	Angiotensinogen	Angiotensinogen	NNP
cord-339752-o6atz33c	67	2	is	be	VBZ
cord-339752-o6atz33c	67	3	produced	produce	VBN
cord-339752-o6atz33c	67	4	in	in	IN
cord-339752-o6atz33c	67	5	the	the	DT
cord-339752-o6atz33c	67	6	liver	liver	NN
cord-339752-o6atz33c	67	7	and	and	CC
cord-339752-o6atz33c	67	8	released	release	VBN
cord-339752-o6atz33c	67	9	into	into	IN
cord-339752-o6atz33c	67	10	the	the	DT
cord-339752-o6atz33c	67	11	blood	blood	NN
cord-339752-o6atz33c	67	12	stream	stream	NN
cord-339752-o6atz33c	67	13	.	.	.
cord-339752-o6atz33c	68	1	The	the	DT
cord-339752-o6atz33c	68	2	renal	renal	JJ
cord-339752-o6atz33c	68	3	juxtaglomerular	juxtaglomerular	JJ
cord-339752-o6atz33c	68	4	apparatus	apparatus	NN
cord-339752-o6atz33c	68	5	-	-	HYPH
cord-339752-o6atz33c	68	6	secreted	secrete	VBN
cord-339752-o6atz33c	68	7	renin	renin	NN
cord-339752-o6atz33c	68	8	cleaves	cleave	VBZ
cord-339752-o6atz33c	68	9	angiotensinogen	angiotensinogen	NNP
cord-339752-o6atz33c	68	10	to	to	IN
cord-339752-o6atz33c	68	11	Ang	Ang	NNP
cord-339752-o6atz33c	68	12	I.	I.	NNP
cord-339752-o6atz33c	68	13	Ang	Ang	NNP
cord-339752-o6atz33c	69	1	I	-PRON-	PRP
cord-339752-o6atz33c	69	2	is	be	VBZ
cord-339752-o6atz33c	69	3	further	further	RB
cord-339752-o6atz33c	69	4	converted	convert	VBN
cord-339752-o6atz33c	69	5	to	to	IN
cord-339752-o6atz33c	69	6	Ang	Ang	NNP
cord-339752-o6atz33c	69	7	II	II	NNP
cord-339752-o6atz33c	69	8	by	by	IN
cord-339752-o6atz33c	69	9	ACE	ACE	NNP
cord-339752-o6atz33c	69	10	which	which	WDT
cord-339752-o6atz33c	69	11	is	be	VBZ
cord-339752-o6atz33c	69	12	mostly	mostly	RB
cord-339752-o6atz33c	69	13	produced	produce	VBN
cord-339752-o6atz33c	69	14	in	in	IN
cord-339752-o6atz33c	69	15	the	the	DT
cord-339752-o6atz33c	69	16	lungs	lung	NNS
cord-339752-o6atz33c	69	17	.	.	.
cord-339752-o6atz33c	70	1	Ang	Ang	NNP
cord-339752-o6atz33c	70	2	II	II	NNP
cord-339752-o6atz33c	70	3	binds	bind	VBZ
cord-339752-o6atz33c	70	4	to	to	IN
cord-339752-o6atz33c	70	5	both	both	CC
cord-339752-o6atz33c	70	6	AT1	at1	NN
cord-339752-o6atz33c	70	7	and	and	CC
cord-339752-o6atz33c	70	8	AT2	at2	NN
cord-339752-o6atz33c	70	9	receptors	receptor	NNS
cord-339752-o6atz33c	70	10	to	to	TO
cord-339752-o6atz33c	70	11	regulate	regulate	VB
cord-339752-o6atz33c	70	12	the	the	DT
cord-339752-o6atz33c	70	13	blood	blood	NN
cord-339752-o6atz33c	70	14	pressure	pressure	NN
cord-339752-o6atz33c	70	15	and	and	CC
cord-339752-o6atz33c	70	16	inflammation	inflammation	NN
cord-339752-o6atz33c	70	17	.	.	.
cord-339752-o6atz33c	71	1	Most	Most	JJS
cord-339752-o6atz33c	71	2	actions	action	NNS
cord-339752-o6atz33c	71	3	of	of	IN
cord-339752-o6atz33c	71	4	Ang	Ang	NNP
cord-339752-o6atz33c	71	5	II	II	NNP
cord-339752-o6atz33c	71	6	occur	occur	VBP
cord-339752-o6atz33c	71	7	via	via	IN
cord-339752-o6atz33c	71	8	the	the	DT
cord-339752-o6atz33c	71	9	AT1	AT1	NNP
cord-339752-o6atz33c	71	10	receptor	receptor	NN
cord-339752-o6atz33c	71	11	.	.	.
cord-339752-o6atz33c	72	1	Meanwhile	meanwhile	RB
cord-339752-o6atz33c	72	2	,	,	,
cord-339752-o6atz33c	72	3	cellular	cellular	JJ
cord-339752-o6atz33c	72	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	72	5	is	be	VBZ
cord-339752-o6atz33c	72	6	cleaved	cleave	VBN
cord-339752-o6atz33c	72	7	by	by	IN
cord-339752-o6atz33c	72	8	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	72	9	.	.	.
cord-339752-o6atz33c	73	1	After	after	IN
cord-339752-o6atz33c	73	2	the	the	DT
cord-339752-o6atz33c	73	3	active	active	JJ
cord-339752-o6atz33c	73	4	form	form	NN
cord-339752-o6atz33c	73	5	of	of	IN
cord-339752-o6atz33c	73	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	73	7	being	be	VBG
cord-339752-o6atz33c	73	8	released	release	VBN
cord-339752-o6atz33c	73	9	into	into	IN
cord-339752-o6atz33c	73	10	the	the	DT
cord-339752-o6atz33c	73	11	extracellular	extracellular	JJ
cord-339752-o6atz33c	73	12	environment	environment	NN
cord-339752-o6atz33c	73	13	,	,	,
cord-339752-o6atz33c	73	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	73	15	converts	convert	VBZ
cord-339752-o6atz33c	73	16	Ang	Ang	NNP
cord-339752-o6atz33c	73	17	I	-PRON-	PRP
cord-339752-o6atz33c	73	18	to	to	IN
cord-339752-o6atz33c	73	19	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	73	20	-	-	HYPH
cord-339752-o6atz33c	73	21	9	9	CD
cord-339752-o6atz33c	73	22	)	)	-RRB-
cord-339752-o6atz33c	73	23	and	and	CC
cord-339752-o6atz33c	74	1	Ang	Ang	NNP
cord-339752-o6atz33c	74	2	II	II	NNP
cord-339752-o6atz33c	74	3	to	to	IN
cord-339752-o6atz33c	74	4	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	74	5	-	-	HYPH
cord-339752-o6atz33c	74	6	7	7	CD
cord-339752-o6atz33c	74	7	)	)	-RRB-
cord-339752-o6atz33c	74	8	.	.	.
cord-339752-o6atz33c	75	1	ACE	ACE	NNP
cord-339752-o6atz33c	75	2	also	also	RB
cord-339752-o6atz33c	75	3	converts	convert	VBZ
cord-339752-o6atz33c	75	4	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	75	5	-	-	HYPH
cord-339752-o6atz33c	75	6	9	9	CD
cord-339752-o6atz33c	75	7	)	)	-RRB-
cord-339752-o6atz33c	75	8	to	to	IN
cord-339752-o6atz33c	75	9	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	75	10	-	-	HYPH
cord-339752-o6atz33c	75	11	7	7	CD
cord-339752-o6atz33c	75	12	)	)	-RRB-
cord-339752-o6atz33c	75	13	.	.	.
cord-339752-o6atz33c	76	1	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	76	2	-	-	HYPH
cord-339752-o6atz33c	76	3	7	7	NNP
cord-339752-o6atz33c	76	4	)	)	-RRB-
cord-339752-o6atz33c	76	5	binds	bind	VBZ
cord-339752-o6atz33c	76	6	to	to	IN
cord-339752-o6atz33c	76	7	Mas	Mas	NNP
cord-339752-o6atz33c	76	8	receptor	receptor	NN
cord-339752-o6atz33c	76	9	to	to	TO
cord-339752-o6atz33c	76	10	mediate	mediate	VB
cord-339752-o6atz33c	76	11	the	the	DT
cord-339752-o6atz33c	76	12	opposite	opposite	JJ
cord-339752-o6atz33c	76	13	effects	effect	NNS
cord-339752-o6atz33c	76	14	of	of	IN
cord-339752-o6atz33c	76	15	Ang	Ang	NNP
cord-339752-o6atz33c	76	16	II	II	NNP
cord-339752-o6atz33c	76	17	.	.	.
cord-339752-o6atz33c	77	1	Genetic	genetic	JJ
cord-339752-o6atz33c	77	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	77	3	deficiency	deficiency	NN
cord-339752-o6atz33c	77	4	is	be	VBZ
cord-339752-o6atz33c	77	5	associated	associate	VBN
cord-339752-o6atz33c	77	6	with	with	IN
cord-339752-o6atz33c	77	7	upregulation	upregulation	NN
cord-339752-o6atz33c	77	8	of	of	IN
cord-339752-o6atz33c	77	9	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	77	10	mediators	mediator	NNS
cord-339752-o6atz33c	77	11	,	,	,
cord-339752-o6atz33c	77	12	elevated	elevate	VBD
cord-339752-o6atz33c	77	13	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	77	14	responsiveness	responsiveness	NN
cord-339752-o6atz33c	77	15	to	to	IN
cord-339752-o6atz33c	77	16	proinflammatory	proinflammatory	JJ
cord-339752-o6atz33c	77	17	stimuli	stimulus	NNS
cord-339752-o6atz33c	77	18	,	,	,
cord-339752-o6atz33c	77	19	and	and	CC
cord-339752-o6atz33c	77	20	enhanced	enhance	VBD
cord-339752-o6atz33c	77	21	Ang	Ang	NNP
cord-339752-o6atz33c	77	22	II	II	NNP
cord-339752-o6atz33c	77	23	-	-	HYPH
cord-339752-o6atz33c	77	24	induced	induce	VBN
cord-339752-o6atz33c	77	25	cardiac	cardiac	JJ
cord-339752-o6atz33c	77	26	and	and	CC
cord-339752-o6atz33c	77	27	aortic	aortic	JJ
cord-339752-o6atz33c	77	28	remodeling	remodeling	NN
cord-339752-o6atz33c	77	29	[	[	-LRB-
cord-339752-o6atz33c	77	30	36	36	CD
cord-339752-o6atz33c	77	31	,	,	,
cord-339752-o6atz33c	77	32	37	37	CD
cord-339752-o6atz33c	77	33	]	]	-RRB-
cord-339752-o6atz33c	77	34	.	.	.
cord-339752-o6atz33c	78	1	The	the	DT
cord-339752-o6atz33c	78	2	anti	anti	JJ
cord-339752-o6atz33c	78	3	-	-	JJ
cord-339752-o6atz33c	78	4	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	78	5	effects	effect	NNS
cord-339752-o6atz33c	78	6	of	of	IN
cord-339752-o6atz33c	78	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	78	8	are	be	VBP
cord-339752-o6atz33c	78	9	exerted	exert	VBN
cord-339752-o6atz33c	78	10	mostly	mostly	RB
cord-339752-o6atz33c	78	11	through	through	IN
cord-339752-o6atz33c	78	12	the	the	DT
cord-339752-o6atz33c	78	13	ACE2-Ang-(1	ACE2-Ang-(1	NNP
cord-339752-o6atz33c	78	14	-	-	HYPH
cord-339752-o6atz33c	78	15	7	7	CD
cord-339752-o6atz33c	78	16	)	)	-RRB-
cord-339752-o6atz33c	78	17	axis	axis	NN
cord-339752-o6atz33c	78	18	against	against	IN
cord-339752-o6atz33c	78	19	Ang	Ang	NNP
cord-339752-o6atz33c	78	20	II	II	NNP
cord-339752-o6atz33c	78	21	-	-	HYPH
cord-339752-o6atz33c	78	22	AT1	at1	NN
cord-339752-o6atz33c	78	23	activities	activity	NNS
cord-339752-o6atz33c	78	24	[	[	-LRB-
cord-339752-o6atz33c	78	25	38	38	CD
cord-339752-o6atz33c	78	26	]	]	-RRB-
cord-339752-o6atz33c	78	27	.	.	.
cord-339752-o6atz33c	79	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	79	2	also	also	RB
cord-339752-o6atz33c	79	3	has	have	VBZ
cord-339752-o6atz33c	79	4	a	a	DT
cord-339752-o6atz33c	79	5	RAAS	RAAS	NNP
cord-339752-o6atz33c	79	6	-	-	HYPH
cord-339752-o6atz33c	79	7	independent	independent	JJ
cord-339752-o6atz33c	79	8	function	function	NN
cord-339752-o6atz33c	79	9	.	.	.
cord-339752-o6atz33c	80	1	In	in	IN
cord-339752-o6atz33c	80	2	the	the	DT
cord-339752-o6atz33c	80	3	intestine	intestine	NN
cord-339752-o6atz33c	80	4	,	,	,
cord-339752-o6atz33c	80	5	cellular	cellular	JJ
cord-339752-o6atz33c	80	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	80	7	(	(	-LRB-
cord-339752-o6atz33c	80	8	not	not	RB
cord-339752-o6atz33c	80	9	circulating	circulate	VBG
cord-339752-o6atz33c	80	10	ACE2	ACE2	NNP
cord-339752-o6atz33c	80	11	)	)	-RRB-
cord-339752-o6atz33c	80	12	regulates	regulate	VBZ
cord-339752-o6atz33c	80	13	the	the	DT
cord-339752-o6atz33c	80	14	absorption	absorption	NN
cord-339752-o6atz33c	80	15	of	of	IN
cord-339752-o6atz33c	80	16	amino	amino	JJ
cord-339752-o6atz33c	80	17	acids	acid	NNS
cord-339752-o6atz33c	80	18	and	and	CC
cord-339752-o6atz33c	80	19	the	the	DT
cord-339752-o6atz33c	80	20	intestinal	intestinal	JJ
cord-339752-o6atz33c	80	21	bacterial	bacterial	JJ
cord-339752-o6atz33c	80	22	balance	balance	NN
cord-339752-o6atz33c	80	23	to	to	TO
cord-339752-o6atz33c	80	24	reduce	reduce	VB
cord-339752-o6atz33c	80	25	intestinal	intestinal	JJ
cord-339752-o6atz33c	80	26	inflammation	inflammation	NN
cord-339752-o6atz33c	80	27	[	[	-LRB-
cord-339752-o6atz33c	80	28	39	39	CD
cord-339752-o6atz33c	80	29	]	]	-RRB-
cord-339752-o6atz33c	80	30	.	.	.
cord-339752-o6atz33c	81	1	Cellular	cellular	JJ
cord-339752-o6atz33c	81	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	81	3	is	be	VBZ
cord-339752-o6atz33c	81	4	required	require	VBN
cord-339752-o6atz33c	81	5	for	for	IN
cord-339752-o6atz33c	81	6	expression	expression	NN
cord-339752-o6atz33c	81	7	of	of	IN
cord-339752-o6atz33c	81	8	the	the	DT
cord-339752-o6atz33c	81	9	neutral	neutral	JJ
cord-339752-o6atz33c	81	10	amino	amino	NN
cord-339752-o6atz33c	81	11	acid	acid	NN
cord-339752-o6atz33c	81	12	transporter	transporter	NN
cord-339752-o6atz33c	81	13	B	b	NN
cord-339752-o6atz33c	81	14	0	0	CD
cord-339752-o6atz33c	81	15	AT1	at1	NN
cord-339752-o6atz33c	81	16	in	in	IN
cord-339752-o6atz33c	81	17	intestinal	intestinal	JJ
cord-339752-o6atz33c	81	18	epithelial	epithelial	JJ
cord-339752-o6atz33c	81	19	cells	cell	NNS
cord-339752-o6atz33c	81	20	[	[	-LRB-
cord-339752-o6atz33c	81	21	40	40	CD
cord-339752-o6atz33c	81	22	]	]	-RRB-
cord-339752-o6atz33c	81	23	.	.	.
cord-339752-o6atz33c	82	1	Without	without	IN
cord-339752-o6atz33c	82	2	ACE2-B	ACE2-B	NNP
cord-339752-o6atz33c	82	3	0	0	CD
cord-339752-o6atz33c	82	4	AT1	at1	NN
cord-339752-o6atz33c	82	5	complex	complex	NN
cord-339752-o6atz33c	82	6	,	,	,
cord-339752-o6atz33c	82	7	serum	serum	NN
cord-339752-o6atz33c	82	8	levels	level	NNS
cord-339752-o6atz33c	82	9	of	of	IN
cord-339752-o6atz33c	82	10	the	the	DT
cord-339752-o6atz33c	82	11	neutral	neutral	JJ
cord-339752-o6atz33c	82	12	amino	amino	NN
cord-339752-o6atz33c	82	13	acids	acid	NNS
cord-339752-o6atz33c	82	14	valine	valine	JJ
cord-339752-o6atz33c	82	15	(	(	-LRB-
cord-339752-o6atz33c	82	16	Val	Val	NNP
cord-339752-o6atz33c	82	17	)	)	-RRB-
cord-339752-o6atz33c	82	18	,	,	,
cord-339752-o6atz33c	82	19	threonine	threonine	NN
cord-339752-o6atz33c	82	20	(	(	-LRB-
cord-339752-o6atz33c	82	21	Thr	Thr	NNP
cord-339752-o6atz33c	82	22	)	)	-RRB-
cord-339752-o6atz33c	82	23	,	,	,
cord-339752-o6atz33c	82	24	and	and	CC
cord-339752-o6atz33c	82	25	tyrosine	tyrosine	NN
cord-339752-o6atz33c	82	26	(	(	-LRB-
cord-339752-o6atz33c	82	27	Tyr	Tyr	NNP
cord-339752-o6atz33c	82	28	)	)	-RRB-
cord-339752-o6atz33c	82	29	,	,	,
cord-339752-o6atz33c	82	30	and	and	CC
cord-339752-o6atz33c	82	31	the	the	DT
cord-339752-o6atz33c	82	32	essential	essential	JJ
cord-339752-o6atz33c	82	33	amino	amino	NN
cord-339752-o6atz33c	82	34	acid	acid	NN
cord-339752-o6atz33c	82	35	tryptophan	tryptophan	NN
cord-339752-o6atz33c	82	36	(	(	-LRB-
cord-339752-o6atz33c	82	37	Trp	trp	NN
cord-339752-o6atz33c	82	38	)	)	-RRB-
cord-339752-o6atz33c	82	39	were	be	VBD
cord-339752-o6atz33c	82	40	markedly	markedly	RB
cord-339752-o6atz33c	82	41	reduced	reduce	VBN
cord-339752-o6atz33c	82	42	and	and	CC
cord-339752-o6atz33c	82	43	resulted	result	VBD
cord-339752-o6atz33c	82	44	in	in	IN
cord-339752-o6atz33c	82	45	severe	severe	JJ
cord-339752-o6atz33c	82	46	intestinal	intestinal	JJ
cord-339752-o6atz33c	82	47	inflammation	inflammation	NN
cord-339752-o6atz33c	82	48	and	and	CC
cord-339752-o6atz33c	82	49	microbial	microbial	JJ
cord-339752-o6atz33c	82	50	imbalance	imbalance	NN
cord-339752-o6atz33c	82	51	in	in	IN
cord-339752-o6atz33c	82	52	ACE2	ACE2	NNP
cord-339752-o6atz33c	82	53	knockout	knockout	NN
cord-339752-o6atz33c	82	54	mice	mouse	NNS
cord-339752-o6atz33c	82	55	.	.	.
cord-339752-o6atz33c	83	1	Administration	administration	NN
cord-339752-o6atz33c	83	2	with	with	IN
cord-339752-o6atz33c	83	3	Trp	Trp	NNP
cord-339752-o6atz33c	83	4	or	or	CC
cord-339752-o6atz33c	83	5	nicotinamide	nicotinamide	NN
cord-339752-o6atz33c	83	6	(	(	-LRB-
cord-339752-o6atz33c	83	7	the	the	DT
cord-339752-o6atz33c	83	8	metabolic	metabolic	JJ
cord-339752-o6atz33c	83	9	product	product	NN
cord-339752-o6atz33c	83	10	of	of	IN
cord-339752-o6atz33c	83	11	Trp	trp	NN
cord-339752-o6atz33c	83	12	)	)	-RRB-
cord-339752-o6atz33c	83	13	could	could	MD
cord-339752-o6atz33c	83	14	increase	increase	VB
cord-339752-o6atz33c	83	15	the	the	DT
cord-339752-o6atz33c	83	16	expression	expression	NN
cord-339752-o6atz33c	83	17	of	of	IN
cord-339752-o6atz33c	83	18	antimicrobial	antimicrobial	JJ
cord-339752-o6atz33c	83	19	peptide	peptide	NN
cord-339752-o6atz33c	83	20	α	α	NNP
cord-339752-o6atz33c	83	21	-	-	HYPH
cord-339752-o6atz33c	83	22	defensins	defensin	NNS
cord-339752-o6atz33c	83	23	and	and	CC
cord-339752-o6atz33c	83	24	reverse	reverse	VB
cord-339752-o6atz33c	83	25	the	the	DT
cord-339752-o6atz33c	83	26	above	above	RB
cord-339752-o6atz33c	83	27	-	-	HYPH
cord-339752-o6atz33c	83	28	mentioned	mention	VBN
cord-339752-o6atz33c	83	29	microbial	microbial	JJ
cord-339752-o6atz33c	83	30	imbalance	imbalance	NN
cord-339752-o6atz33c	83	31	and	and	CC
cord-339752-o6atz33c	83	32	inflammation	inflammation	NN
cord-339752-o6atz33c	83	33	in	in	IN
cord-339752-o6atz33c	83	34	the	the	DT
cord-339752-o6atz33c	83	35	gut	gut	NN
cord-339752-o6atz33c	83	36	.	.	.
cord-339752-o6atz33c	84	1	Structural	structural	JJ
cord-339752-o6atz33c	84	2	modelling	modelling	NN
cord-339752-o6atz33c	84	3	suggested	suggest	VBD
cord-339752-o6atz33c	84	4	that	that	IN
cord-339752-o6atz33c	84	5	the	the	DT
cord-339752-o6atz33c	84	6	ACE2-B	ACE2-B	NNP
cord-339752-o6atz33c	84	7	0	0	CD
cord-339752-o6atz33c	84	8	AT1	at1	NN
cord-339752-o6atz33c	84	9	complex	complex	NN
cord-339752-o6atz33c	84	10	could	could	MD
cord-339752-o6atz33c	84	11	bind	bind	VB
cord-339752-o6atz33c	84	12	to	to	IN
cord-339752-o6atz33c	84	13	the	the	DT
cord-339752-o6atz33c	84	14	S	s	NN
cord-339752-o6atz33c	84	15	-	-	HYPH
cord-339752-o6atz33c	84	16	protein	protein	NN
cord-339752-o6atz33c	84	17	of	of	IN
cord-339752-o6atz33c	84	18	SARS	SARS	NNP
cord-339752-o6atz33c	84	19	-	-	:
cord-339752-o6atz33c	84	20	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	84	21	simultaneously	simultaneously	RB
cord-339752-o6atz33c	84	22	[	[	-LRB-
cord-339752-o6atz33c	84	23	41	41	CD
cord-339752-o6atz33c	84	24	]	]	-RRB-
cord-339752-o6atz33c	84	25	.	.	.
cord-339752-o6atz33c	85	1	The	the	DT
cord-339752-o6atz33c	85	2	intestinal	intestinal	JJ
cord-339752-o6atz33c	85	3	cellular	cellular	JJ
cord-339752-o6atz33c	85	4	Angiotensinogen	Angiotensinogen	NNP
cord-339752-o6atz33c	85	5	is	be	VBZ
cord-339752-o6atz33c	85	6	produced	produce	VBN
cord-339752-o6atz33c	85	7	in	in	IN
cord-339752-o6atz33c	85	8	the	the	DT
cord-339752-o6atz33c	85	9	liver	liver	NN
cord-339752-o6atz33c	85	10	and	and	CC
cord-339752-o6atz33c	85	11	released	release	VBN
cord-339752-o6atz33c	85	12	into	into	IN
cord-339752-o6atz33c	85	13	the	the	DT
cord-339752-o6atz33c	85	14	blood	blood	NN
cord-339752-o6atz33c	85	15	stream	stream	NN
cord-339752-o6atz33c	85	16	.	.	.
cord-339752-o6atz33c	86	1	The	the	DT
cord-339752-o6atz33c	86	2	renal	renal	JJ
cord-339752-o6atz33c	86	3	juxtaglomerular	juxtaglomerular	JJ
cord-339752-o6atz33c	86	4	apparatus	apparatus	NN
cord-339752-o6atz33c	86	5	-	-	HYPH
cord-339752-o6atz33c	86	6	secreted	secrete	VBN
cord-339752-o6atz33c	86	7	renin	renin	NN
cord-339752-o6atz33c	86	8	cleaves	cleave	VBZ
cord-339752-o6atz33c	86	9	angiotensinogen	angiotensinogen	NNP
cord-339752-o6atz33c	86	10	to	to	IN
cord-339752-o6atz33c	86	11	Ang	Ang	NNP
cord-339752-o6atz33c	86	12	I.	I.	NNP
cord-339752-o6atz33c	86	13	Ang	Ang	NNP
cord-339752-o6atz33c	87	1	I	-PRON-	PRP
cord-339752-o6atz33c	87	2	is	be	VBZ
cord-339752-o6atz33c	87	3	further	further	RB
cord-339752-o6atz33c	87	4	converted	convert	VBN
cord-339752-o6atz33c	87	5	to	to	IN
cord-339752-o6atz33c	87	6	Ang	Ang	NNP
cord-339752-o6atz33c	87	7	II	II	NNP
cord-339752-o6atz33c	87	8	by	by	IN
cord-339752-o6atz33c	87	9	ACE	ACE	NNP
cord-339752-o6atz33c	87	10	which	which	WDT
cord-339752-o6atz33c	87	11	is	be	VBZ
cord-339752-o6atz33c	87	12	mostly	mostly	RB
cord-339752-o6atz33c	87	13	produced	produce	VBN
cord-339752-o6atz33c	87	14	in	in	IN
cord-339752-o6atz33c	87	15	the	the	DT
cord-339752-o6atz33c	87	16	lungs	lung	NNS
cord-339752-o6atz33c	87	17	.	.	.
cord-339752-o6atz33c	88	1	Ang	Ang	NNP
cord-339752-o6atz33c	88	2	II	II	NNP
cord-339752-o6atz33c	88	3	binds	bind	VBZ
cord-339752-o6atz33c	88	4	to	to	IN
cord-339752-o6atz33c	88	5	both	both	CC
cord-339752-o6atz33c	88	6	AT	at	IN
cord-339752-o6atz33c	88	7	1	1	CD
cord-339752-o6atz33c	88	8	and	and	CC
cord-339752-o6atz33c	88	9	AT	at	IN
cord-339752-o6atz33c	88	10	2	2	CD
cord-339752-o6atz33c	88	11	receptors	receptor	NNS
cord-339752-o6atz33c	88	12	to	to	TO
cord-339752-o6atz33c	88	13	regulate	regulate	VB
cord-339752-o6atz33c	88	14	the	the	DT
cord-339752-o6atz33c	88	15	blood	blood	NN
cord-339752-o6atz33c	88	16	pressure	pressure	NN
cord-339752-o6atz33c	88	17	and	and	CC
cord-339752-o6atz33c	88	18	inflammation	inflammation	NN
cord-339752-o6atz33c	88	19	.	.	.
cord-339752-o6atz33c	89	1	Most	Most	JJS
cord-339752-o6atz33c	89	2	actions	action	NNS
cord-339752-o6atz33c	89	3	of	of	IN
cord-339752-o6atz33c	89	4	Ang	Ang	NNP
cord-339752-o6atz33c	89	5	II	II	NNP
cord-339752-o6atz33c	89	6	occur	occur	VBP
cord-339752-o6atz33c	89	7	via	via	IN
cord-339752-o6atz33c	89	8	the	the	DT
cord-339752-o6atz33c	89	9	AT	AT	NNP
cord-339752-o6atz33c	89	10	1	1	CD
cord-339752-o6atz33c	89	11	receptor	receptor	NN
cord-339752-o6atz33c	89	12	.	.	.
cord-339752-o6atz33c	90	1	Meanwhile	meanwhile	RB
cord-339752-o6atz33c	90	2	,	,	,
cord-339752-o6atz33c	90	3	cellular	cellular	JJ
cord-339752-o6atz33c	90	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	90	5	is	be	VBZ
cord-339752-o6atz33c	90	6	cleaved	cleave	VBN
cord-339752-o6atz33c	90	7	by	by	IN
cord-339752-o6atz33c	90	8	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	90	9	.	.	.
cord-339752-o6atz33c	91	1	After	after	IN
cord-339752-o6atz33c	91	2	the	the	DT
cord-339752-o6atz33c	91	3	active	active	JJ
cord-339752-o6atz33c	91	4	form	form	NN
cord-339752-o6atz33c	91	5	of	of	IN
cord-339752-o6atz33c	91	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	91	7	being	be	VBG
cord-339752-o6atz33c	91	8	released	release	VBN
cord-339752-o6atz33c	91	9	into	into	IN
cord-339752-o6atz33c	91	10	the	the	DT
cord-339752-o6atz33c	91	11	extracellular	extracellular	JJ
cord-339752-o6atz33c	91	12	environment	environment	NN
cord-339752-o6atz33c	91	13	,	,	,
cord-339752-o6atz33c	91	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	91	15	converts	convert	VBZ
cord-339752-o6atz33c	91	16	Ang	Ang	NNP
cord-339752-o6atz33c	91	17	I	-PRON-	PRP
cord-339752-o6atz33c	91	18	to	to	IN
cord-339752-o6atz33c	91	19	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	91	20	-	-	HYPH
cord-339752-o6atz33c	91	21	9	9	CD
cord-339752-o6atz33c	91	22	)	)	-RRB-
cord-339752-o6atz33c	91	23	and	and	CC
cord-339752-o6atz33c	92	1	Ang	Ang	NNP
cord-339752-o6atz33c	92	2	II	II	NNP
cord-339752-o6atz33c	92	3	to	to	IN
cord-339752-o6atz33c	92	4	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	92	5	-	-	HYPH
cord-339752-o6atz33c	92	6	7	7	CD
cord-339752-o6atz33c	92	7	)	)	-RRB-
cord-339752-o6atz33c	92	8	.	.	.
cord-339752-o6atz33c	93	1	ACE	ACE	NNP
cord-339752-o6atz33c	93	2	also	also	RB
cord-339752-o6atz33c	93	3	converts	convert	VBZ
cord-339752-o6atz33c	93	4	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	93	5	-	-	HYPH
cord-339752-o6atz33c	93	6	9	9	CD
cord-339752-o6atz33c	93	7	)	)	-RRB-
cord-339752-o6atz33c	93	8	to	to	IN
cord-339752-o6atz33c	93	9	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	93	10	-	-	HYPH
cord-339752-o6atz33c	93	11	7	7	CD
cord-339752-o6atz33c	93	12	)	)	-RRB-
cord-339752-o6atz33c	93	13	.	.	.
cord-339752-o6atz33c	94	1	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	94	2	-	-	HYPH
cord-339752-o6atz33c	94	3	7	7	NNP
cord-339752-o6atz33c	94	4	)	)	-RRB-
cord-339752-o6atz33c	94	5	binds	bind	VBZ
cord-339752-o6atz33c	94	6	to	to	IN
cord-339752-o6atz33c	94	7	Mas	Mas	NNP
cord-339752-o6atz33c	94	8	receptor	receptor	NN
cord-339752-o6atz33c	94	9	to	to	TO
cord-339752-o6atz33c	94	10	mediate	mediate	VB
cord-339752-o6atz33c	94	11	the	the	DT
cord-339752-o6atz33c	94	12	opposite	opposite	JJ
cord-339752-o6atz33c	94	13	effects	effect	NNS
cord-339752-o6atz33c	94	14	of	of	IN
cord-339752-o6atz33c	94	15	Ang	Ang	NNP
cord-339752-o6atz33c	94	16	II	II	NNP
cord-339752-o6atz33c	94	17	.	.	.
cord-339752-o6atz33c	95	1	Genetic	genetic	JJ
cord-339752-o6atz33c	95	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	95	3	deficiency	deficiency	NN
cord-339752-o6atz33c	95	4	is	be	VBZ
cord-339752-o6atz33c	95	5	associated	associate	VBN
cord-339752-o6atz33c	95	6	with	with	IN
cord-339752-o6atz33c	95	7	upregulation	upregulation	NN
cord-339752-o6atz33c	95	8	of	of	IN
cord-339752-o6atz33c	95	9	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	95	10	mediators	mediator	NNS
cord-339752-o6atz33c	95	11	,	,	,
cord-339752-o6atz33c	95	12	elevated	elevate	VBD
cord-339752-o6atz33c	95	13	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	95	14	responsiveness	responsiveness	NN
cord-339752-o6atz33c	95	15	to	to	IN
cord-339752-o6atz33c	95	16	proinflammatory	proinflammatory	JJ
cord-339752-o6atz33c	95	17	stimuli	stimulus	NNS
cord-339752-o6atz33c	95	18	,	,	,
cord-339752-o6atz33c	95	19	and	and	CC
cord-339752-o6atz33c	95	20	enhanced	enhance	VBD
cord-339752-o6atz33c	95	21	Ang	Ang	NNP
cord-339752-o6atz33c	95	22	II	II	NNP
cord-339752-o6atz33c	95	23	-	-	HYPH
cord-339752-o6atz33c	95	24	induced	induce	VBN
cord-339752-o6atz33c	95	25	cardiac	cardiac	JJ
cord-339752-o6atz33c	95	26	and	and	CC
cord-339752-o6atz33c	95	27	aortic	aortic	JJ
cord-339752-o6atz33c	95	28	remodeling	remodeling	NN
cord-339752-o6atz33c	95	29	[	[	-LRB-
cord-339752-o6atz33c	95	30	36	36	CD
cord-339752-o6atz33c	95	31	,	,	,
cord-339752-o6atz33c	95	32	37	37	CD
cord-339752-o6atz33c	95	33	]	]	-RRB-
cord-339752-o6atz33c	95	34	.	.	.
cord-339752-o6atz33c	96	1	The	the	DT
cord-339752-o6atz33c	96	2	anti	anti	JJ
cord-339752-o6atz33c	96	3	-	-	JJ
cord-339752-o6atz33c	96	4	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	96	5	effects	effect	NNS
cord-339752-o6atz33c	96	6	of	of	IN
cord-339752-o6atz33c	96	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	96	8	are	be	VBP
cord-339752-o6atz33c	96	9	exerted	exert	VBN
cord-339752-o6atz33c	96	10	mostly	mostly	RB
cord-339752-o6atz33c	96	11	through	through	IN
cord-339752-o6atz33c	96	12	the	the	DT
cord-339752-o6atz33c	96	13	ACE2-Ang-(1	ACE2-Ang-(1	NNP
cord-339752-o6atz33c	96	14	-	-	HYPH
cord-339752-o6atz33c	96	15	7	7	CD
cord-339752-o6atz33c	96	16	)	)	-RRB-
cord-339752-o6atz33c	96	17	axis	axis	NN
cord-339752-o6atz33c	96	18	against	against	IN
cord-339752-o6atz33c	96	19	Ang	Ang	NNP
cord-339752-o6atz33c	96	20	II-	II-	NNP
cord-339752-o6atz33c	97	1	AT	at	IN
cord-339752-o6atz33c	97	2	1	1	CD
cord-339752-o6atz33c	97	3	activities	activity	NNS
cord-339752-o6atz33c	97	4	[	[	-LRB-
cord-339752-o6atz33c	97	5	38	38	CD
cord-339752-o6atz33c	97	6	]	]	-RRB-
cord-339752-o6atz33c	97	7	.	.	.
cord-339752-o6atz33c	98	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	98	2	also	also	RB
cord-339752-o6atz33c	98	3	has	have	VBZ
cord-339752-o6atz33c	98	4	a	a	DT
cord-339752-o6atz33c	98	5	RAAS	RAAS	NNP
cord-339752-o6atz33c	98	6	-	-	HYPH
cord-339752-o6atz33c	98	7	independent	independent	JJ
cord-339752-o6atz33c	98	8	function	function	NN
cord-339752-o6atz33c	98	9	.	.	.
cord-339752-o6atz33c	99	1	In	in	IN
cord-339752-o6atz33c	99	2	the	the	DT
cord-339752-o6atz33c	99	3	intestine	intestine	NN
cord-339752-o6atz33c	99	4	,	,	,
cord-339752-o6atz33c	99	5	cellular	cellular	JJ
cord-339752-o6atz33c	99	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	99	7	(	(	-LRB-
cord-339752-o6atz33c	99	8	not	not	RB
cord-339752-o6atz33c	99	9	circulating	circulate	VBG
cord-339752-o6atz33c	99	10	ACE2	ACE2	NNP
cord-339752-o6atz33c	99	11	)	)	-RRB-
cord-339752-o6atz33c	99	12	regulates	regulate	VBZ
cord-339752-o6atz33c	99	13	the	the	DT
cord-339752-o6atz33c	99	14	absorption	absorption	NN
cord-339752-o6atz33c	99	15	of	of	IN
cord-339752-o6atz33c	99	16	amino	amino	JJ
cord-339752-o6atz33c	99	17	acids	acid	NNS
cord-339752-o6atz33c	99	18	and	and	CC
cord-339752-o6atz33c	99	19	the	the	DT
cord-339752-o6atz33c	99	20	intestinal	intestinal	JJ
cord-339752-o6atz33c	99	21	bacterial	bacterial	JJ
cord-339752-o6atz33c	99	22	balance	balance	NN
cord-339752-o6atz33c	99	23	to	to	TO
cord-339752-o6atz33c	99	24	reduce	reduce	VB
cord-339752-o6atz33c	99	25	intestinal	intestinal	JJ
cord-339752-o6atz33c	99	26	inflammation	inflammation	NN
cord-339752-o6atz33c	99	27	[	[	-LRB-
cord-339752-o6atz33c	99	28	39	39	CD
cord-339752-o6atz33c	99	29	]	]	-RRB-
cord-339752-o6atz33c	99	30	.	.	.
cord-339752-o6atz33c	100	1	Cellular	cellular	JJ
cord-339752-o6atz33c	100	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	100	3	is	be	VBZ
cord-339752-o6atz33c	100	4	required	require	VBN
cord-339752-o6atz33c	100	5	for	for	IN
cord-339752-o6atz33c	100	6	expression	expression	NN
cord-339752-o6atz33c	100	7	of	of	IN
cord-339752-o6atz33c	100	8	the	the	DT
cord-339752-o6atz33c	100	9	neutral	neutral	JJ
cord-339752-o6atz33c	100	10	amino	amino	NN
cord-339752-o6atz33c	100	11	acid	acid	NN
cord-339752-o6atz33c	100	12	transporter	transporter	NN
cord-339752-o6atz33c	100	13	B	b	NN
cord-339752-o6atz33c	100	14	0	0	CD
cord-339752-o6atz33c	100	15	AT1	at1	NN
cord-339752-o6atz33c	100	16	in	in	IN
cord-339752-o6atz33c	100	17	intestinal	intestinal	JJ
cord-339752-o6atz33c	100	18	epithelial	epithelial	JJ
cord-339752-o6atz33c	100	19	cells	cell	NNS
cord-339752-o6atz33c	100	20	[	[	-LRB-
cord-339752-o6atz33c	100	21	40	40	CD
cord-339752-o6atz33c	100	22	]	]	-RRB-
cord-339752-o6atz33c	100	23	.	.	.
cord-339752-o6atz33c	101	1	Without	without	IN
cord-339752-o6atz33c	101	2	ACE2-B	ACE2-B	NNP
cord-339752-o6atz33c	101	3	0	0	CD
cord-339752-o6atz33c	101	4	AT1	at1	NN
cord-339752-o6atz33c	101	5	complex	complex	NN
cord-339752-o6atz33c	101	6	,	,	,
cord-339752-o6atz33c	101	7	serum	serum	NN
cord-339752-o6atz33c	101	8	levels	level	NNS
cord-339752-o6atz33c	101	9	of	of	IN
cord-339752-o6atz33c	101	10	the	the	DT
cord-339752-o6atz33c	101	11	neutral	neutral	JJ
cord-339752-o6atz33c	101	12	amino	amino	NN
cord-339752-o6atz33c	101	13	acids	acid	NNS
cord-339752-o6atz33c	101	14	valine	valine	JJ
cord-339752-o6atz33c	101	15	(	(	-LRB-
cord-339752-o6atz33c	101	16	Val	Val	NNP
cord-339752-o6atz33c	101	17	)	)	-RRB-
cord-339752-o6atz33c	101	18	,	,	,
cord-339752-o6atz33c	101	19	threonine	threonine	NN
cord-339752-o6atz33c	101	20	(	(	-LRB-
cord-339752-o6atz33c	101	21	Thr	Thr	NNP
cord-339752-o6atz33c	101	22	)	)	-RRB-
cord-339752-o6atz33c	101	23	,	,	,
cord-339752-o6atz33c	101	24	and	and	CC
cord-339752-o6atz33c	101	25	tyrosine	tyrosine	NN
cord-339752-o6atz33c	101	26	(	(	-LRB-
cord-339752-o6atz33c	101	27	Tyr	Tyr	NNP
cord-339752-o6atz33c	101	28	)	)	-RRB-
cord-339752-o6atz33c	101	29	,	,	,
cord-339752-o6atz33c	101	30	and	and	CC
cord-339752-o6atz33c	101	31	the	the	DT
cord-339752-o6atz33c	101	32	essential	essential	JJ
cord-339752-o6atz33c	101	33	amino	amino	NN
cord-339752-o6atz33c	101	34	acid	acid	NN
cord-339752-o6atz33c	101	35	tryptophan	tryptophan	NN
cord-339752-o6atz33c	101	36	(	(	-LRB-
cord-339752-o6atz33c	101	37	Trp	trp	NN
cord-339752-o6atz33c	101	38	)	)	-RRB-
cord-339752-o6atz33c	101	39	were	be	VBD
cord-339752-o6atz33c	101	40	markedly	markedly	RB
cord-339752-o6atz33c	101	41	reduced	reduce	VBN
cord-339752-o6atz33c	101	42	and	and	CC
cord-339752-o6atz33c	101	43	resulted	result	VBD
cord-339752-o6atz33c	101	44	in	in	IN
cord-339752-o6atz33c	101	45	severe	severe	JJ
cord-339752-o6atz33c	101	46	intestinal	intestinal	JJ
cord-339752-o6atz33c	101	47	inflammation	inflammation	NN
cord-339752-o6atz33c	101	48	and	and	CC
cord-339752-o6atz33c	101	49	microbial	microbial	JJ
cord-339752-o6atz33c	101	50	imbalance	imbalance	NN
cord-339752-o6atz33c	101	51	in	in	IN
cord-339752-o6atz33c	101	52	ACE2	ACE2	NNP
cord-339752-o6atz33c	101	53	knockout	knockout	NN
cord-339752-o6atz33c	101	54	mice	mouse	NNS
cord-339752-o6atz33c	101	55	.	.	.
cord-339752-o6atz33c	102	1	Administration	administration	NN
cord-339752-o6atz33c	102	2	with	with	IN
cord-339752-o6atz33c	102	3	Trp	Trp	NNP
cord-339752-o6atz33c	102	4	or	or	CC
cord-339752-o6atz33c	102	5	nicotinamide	nicotinamide	NN
cord-339752-o6atz33c	102	6	(	(	-LRB-
cord-339752-o6atz33c	102	7	the	the	DT
cord-339752-o6atz33c	102	8	metabolic	metabolic	JJ
cord-339752-o6atz33c	102	9	product	product	NN
cord-339752-o6atz33c	102	10	of	of	IN
cord-339752-o6atz33c	102	11	Trp	trp	NN
cord-339752-o6atz33c	102	12	)	)	-RRB-
cord-339752-o6atz33c	102	13	could	could	MD
cord-339752-o6atz33c	102	14	increase	increase	VB
cord-339752-o6atz33c	102	15	the	the	DT
cord-339752-o6atz33c	102	16	expression	expression	NN
cord-339752-o6atz33c	102	17	of	of	IN
cord-339752-o6atz33c	102	18	antimicrobial	antimicrobial	JJ
cord-339752-o6atz33c	102	19	peptide	peptide	NN
cord-339752-o6atz33c	102	20	α	α	NNP
cord-339752-o6atz33c	102	21	-	-	HYPH
cord-339752-o6atz33c	102	22	defensins	defensin	NNS
cord-339752-o6atz33c	102	23	and	and	CC
cord-339752-o6atz33c	102	24	reverse	reverse	VB
cord-339752-o6atz33c	102	25	the	the	DT
cord-339752-o6atz33c	102	26	above	above	RB
cord-339752-o6atz33c	102	27	-	-	HYPH
cord-339752-o6atz33c	102	28	mentioned	mention	VBN
cord-339752-o6atz33c	102	29	microbial	microbial	JJ
cord-339752-o6atz33c	102	30	imbalance	imbalance	NN
cord-339752-o6atz33c	102	31	and	and	CC
cord-339752-o6atz33c	102	32	inflammation	inflammation	NN
cord-339752-o6atz33c	102	33	in	in	IN
cord-339752-o6atz33c	102	34	the	the	DT
cord-339752-o6atz33c	102	35	gut	gut	NN
cord-339752-o6atz33c	102	36	.	.	.
cord-339752-o6atz33c	103	1	Structural	structural	JJ
cord-339752-o6atz33c	103	2	modelling	modelling	NN
cord-339752-o6atz33c	103	3	suggested	suggest	VBD
cord-339752-o6atz33c	103	4	that	that	IN
cord-339752-o6atz33c	103	5	the	the	DT
cord-339752-o6atz33c	103	6	ACE2-B	ACE2-B	NNP
cord-339752-o6atz33c	103	7	0	0	CD
cord-339752-o6atz33c	103	8	AT1	at1	NN
cord-339752-o6atz33c	103	9	complex	complex	NN
cord-339752-o6atz33c	103	10	could	could	MD
cord-339752-o6atz33c	103	11	bind	bind	VB
cord-339752-o6atz33c	103	12	to	to	IN
cord-339752-o6atz33c	103	13	the	the	DT
cord-339752-o6atz33c	103	14	S	s	NN
cord-339752-o6atz33c	103	15	-	-	HYPH
cord-339752-o6atz33c	103	16	protein	protein	NN
cord-339752-o6atz33c	103	17	of	of	IN
cord-339752-o6atz33c	103	18	SARS	SARS	NNP
cord-339752-o6atz33c	103	19	-	-	:
cord-339752-o6atz33c	103	20	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	103	21	simultaneously	simultaneously	RB
cord-339752-o6atz33c	103	22	[	[	-LRB-
cord-339752-o6atz33c	103	23	41	41	CD
cord-339752-o6atz33c	103	24	]	]	-RRB-
cord-339752-o6atz33c	103	25	.	.	.
cord-339752-o6atz33c	104	1	The	the	DT
cord-339752-o6atz33c	104	2	intestinal	intestinal	JJ
cord-339752-o6atz33c	104	3	cellular	cellular	JJ
cord-339752-o6atz33c	104	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	104	5	might	may	MD
cord-339752-o6atz33c	104	6	be	be	VB
cord-339752-o6atz33c	104	7	another	another	DT
cord-339752-o6atz33c	104	8	viral	viral	JJ
cord-339752-o6atz33c	104	9	entry	entry	NN
cord-339752-o6atz33c	104	10	point	point	NN
cord-339752-o6atz33c	104	11	for	for	IN
cord-339752-o6atz33c	104	12	SARS	SARS	NNP
cord-339752-o6atz33c	104	13	-	-	HYPH
cord-339752-o6atz33c	104	14	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	104	15	as	as	RB
cord-339752-o6atz33c	104	16	well	well	RB
cord-339752-o6atz33c	104	17	as	as	IN
cord-339752-o6atz33c	104	18	TMPRSS2-sheded	TMPRSS2-sheded	NNP
cord-339752-o6atz33c	104	19	ACE2	ACE2	NNP
cord-339752-o6atz33c	104	20	in	in	IN
cord-339752-o6atz33c	104	21	the	the	DT
cord-339752-o6atz33c	104	22	lungs	lung	NNS
cord-339752-o6atz33c	104	23	.	.	.
cord-339752-o6atz33c	105	1	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	105	2	is	be	VBZ
cord-339752-o6atz33c	105	3	a	a	DT
cord-339752-o6atz33c	105	4	lower	low	JJR
cord-339752-o6atz33c	105	5	respiratory	respiratory	JJ
cord-339752-o6atz33c	105	6	tract	tract	NN
cord-339752-o6atz33c	105	7	disease	disease	NN
cord-339752-o6atz33c	105	8	.	.	.
cord-339752-o6atz33c	106	1	The	the	DT
cord-339752-o6atz33c	106	2	first	first	JJ
cord-339752-o6atz33c	106	3	anatomic	anatomic	JJ
cord-339752-o6atz33c	106	4	pathology	pathology	NN
cord-339752-o6atz33c	106	5	report	report	NN
cord-339752-o6atz33c	106	6	of	of	IN
cord-339752-o6atz33c	106	7	a	a	DT
cord-339752-o6atz33c	106	8	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	106	9	death	death	NN
cord-339752-o6atz33c	106	10	indicated	indicate	VBD
cord-339752-o6atz33c	106	11	that	that	IN
cord-339752-o6atz33c	106	12	the	the	DT
cord-339752-o6atz33c	106	13	most	most	RBS
cord-339752-o6atz33c	106	14	seriously	seriously	RB
cord-339752-o6atz33c	106	15	injured	injure	VBN
cord-339752-o6atz33c	106	16	organs	organ	NNS
cord-339752-o6atz33c	106	17	were	be	VBD
cord-339752-o6atz33c	106	18	the	the	DT
cord-339752-o6atz33c	106	19	lungs	lung	NNS
cord-339752-o6atz33c	106	20	.	.	.
cord-339752-o6atz33c	107	1	Exudative	Exudative	NNP
cord-339752-o6atz33c	107	2	lesions	lesion	NNS
cord-339752-o6atz33c	107	3	and	and	CC
cord-339752-o6atz33c	107	4	fibrosis	fibrosis	NN
cord-339752-o6atz33c	107	5	were	be	VBD
cord-339752-o6atz33c	107	6	observed	observe	VBN
cord-339752-o6atz33c	107	7	in	in	IN
cord-339752-o6atz33c	107	8	the	the	DT
cord-339752-o6atz33c	107	9	lungs	lung	NNS
cord-339752-o6atz33c	107	10	.	.	.
cord-339752-o6atz33c	108	1	Phlegm	phlegm	NN
cord-339752-o6atz33c	108	2	and	and	CC
cord-339752-o6atz33c	108	3	exudates	exudate	NNS
cord-339752-o6atz33c	108	4	filled	fill	VBN
cord-339752-o6atz33c	108	5	up	up	RP
cord-339752-o6atz33c	108	6	the	the	DT
cord-339752-o6atz33c	108	7	lower	low	JJR
cord-339752-o6atz33c	108	8	respiratory	respiratory	JJ
cord-339752-o6atz33c	108	9	tract	tract	NN
cord-339752-o6atz33c	108	10	and	and	CC
cord-339752-o6atz33c	108	11	pulmonary	pulmonary	JJ
cord-339752-o6atz33c	108	12	alveolus	alveolus	NN
cord-339752-o6atz33c	108	13	.	.	.
cord-339752-o6atz33c	109	1	Compared	compare	VBN
cord-339752-o6atz33c	109	2	to	to	IN
cord-339752-o6atz33c	109	3	SARS	SARS	NNP
cord-339752-o6atz33c	109	4	,	,	,
cord-339752-o6atz33c	109	5	the	the	DT
cord-339752-o6atz33c	109	6	exudative	exudative	JJ
cord-339752-o6atz33c	109	7	lesions	lesion	NNS
cord-339752-o6atz33c	109	8	were	be	VBD
cord-339752-o6atz33c	109	9	far	far	RB
cord-339752-o6atz33c	109	10	worse	bad	JJR
cord-339752-o6atz33c	109	11	but	but	CC
cord-339752-o6atz33c	109	12	the	the	DT
cord-339752-o6atz33c	109	13	fibrosis	fibrosis	NN
cord-339752-o6atz33c	109	14	was	be	VBD
cord-339752-o6atz33c	109	15	much	much	RB
cord-339752-o6atz33c	109	16	lighter	light	JJR
cord-339752-o6atz33c	109	17	.	.	.
cord-339752-o6atz33c	110	1	Notably	notably	RB
cord-339752-o6atz33c	110	2	,	,	,
cord-339752-o6atz33c	110	3	segmental	segmental	JJ
cord-339752-o6atz33c	110	4	dilatation	dilatation	NN
cord-339752-o6atz33c	110	5	and	and	CC
cord-339752-o6atz33c	110	6	stenosis	stenosis	NN
cord-339752-o6atz33c	110	7	of	of	IN
cord-339752-o6atz33c	110	8	the	the	DT
cord-339752-o6atz33c	110	9	small	small	JJ
cord-339752-o6atz33c	110	10	intestine	intestine	NN
cord-339752-o6atz33c	110	11	were	be	VBD
cord-339752-o6atz33c	110	12	observed	observe	VBN
cord-339752-o6atz33c	110	13	in	in	IN
cord-339752-o6atz33c	110	14	the	the	DT
cord-339752-o6atz33c	110	15	cadaver	cadaver	NN
cord-339752-o6atz33c	110	16	suggesting	suggest	VBG
cord-339752-o6atz33c	110	17	that	that	IN
cord-339752-o6atz33c	110	18	the	the	DT
cord-339752-o6atz33c	110	19	small	small	JJ
cord-339752-o6atz33c	110	20	intestine	intestine	NN
cord-339752-o6atz33c	110	21	was	be	VBD
cord-339752-o6atz33c	110	22	also	also	RB
cord-339752-o6atz33c	110	23	severely	severely	RB
cord-339752-o6atz33c	110	24	injured	injure	VBN
cord-339752-o6atz33c	110	25	by	by	IN
cord-339752-o6atz33c	110	26	SARS	SARS	NNP
cord-339752-o6atz33c	110	27	-	-	HYPH
cord-339752-o6atz33c	110	28	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	110	29	infection	infection	NN
cord-339752-o6atz33c	110	30	.	.	.
cord-339752-o6atz33c	111	1	Lesions	lesion	NNS
cord-339752-o6atz33c	111	2	on	on	IN
cord-339752-o6atz33c	111	3	other	other	JJ
cord-339752-o6atz33c	111	4	organs	organ	NNS
cord-339752-o6atz33c	111	5	were	be	VBD
cord-339752-o6atz33c	111	6	not	not	RB
cord-339752-o6atz33c	111	7	obvious	obvious	JJ
cord-339752-o6atz33c	111	8	[	[	-LRB-
cord-339752-o6atz33c	111	9	42	42	CD
cord-339752-o6atz33c	111	10	]	]	-RRB-
cord-339752-o6atz33c	111	11	.	.	.
cord-339752-o6atz33c	112	1	The	the	DT
cord-339752-o6atz33c	112	2	pathological	pathological	JJ
cord-339752-o6atz33c	112	3	findings	finding	NNS
cord-339752-o6atz33c	112	4	of	of	IN
cord-339752-o6atz33c	112	5	another	another	DT
cord-339752-o6atz33c	112	6	COVID-19	covid-19	JJ
cord-339752-o6atz33c	112	7	victim	victim	NN
cord-339752-o6atz33c	112	8	showed	show	VBD
cord-339752-o6atz33c	112	9	that	that	IN
cord-339752-o6atz33c	112	10	the	the	DT
cord-339752-o6atz33c	112	11	bilateral	bilateral	JJ
cord-339752-o6atz33c	112	12	diffuse	diffuse	JJ
cord-339752-o6atz33c	112	13	alveolar	alveolar	NN
cord-339752-o6atz33c	112	14	damage	damage	NN
cord-339752-o6atz33c	112	15	with	with	IN
cord-339752-o6atz33c	112	16	cellular	cellular	JJ
cord-339752-o6atz33c	112	17	fibromyxoid	fibromyxoid	NN
cord-339752-o6atz33c	112	18	exudates	exudate	NNS
cord-339752-o6atz33c	112	19	,	,	,
cord-339752-o6atz33c	112	20	desquamation	desquamation	NN
cord-339752-o6atz33c	112	21	of	of	IN
cord-339752-o6atz33c	112	22	pneumocytes	pneumocyte	NNS
cord-339752-o6atz33c	112	23	,	,	,
cord-339752-o6atz33c	112	24	and	and	CC
cord-339752-o6atz33c	112	25	hyaline	hyaline	JJ
cord-339752-o6atz33c	112	26	membrane	membrane	NN
cord-339752-o6atz33c	112	27	formation	formation	NN
cord-339752-o6atz33c	112	28	occurred	occur	VBD
cord-339752-o6atz33c	112	29	in	in	IN
cord-339752-o6atz33c	112	30	the	the	DT
cord-339752-o6atz33c	112	31	lungs	lung	NNS
cord-339752-o6atz33c	112	32	[	[	-LRB-
cord-339752-o6atz33c	112	33	43	43	CD
cord-339752-o6atz33c	112	34	]	]	-RRB-
cord-339752-o6atz33c	112	35	.	.	.
cord-339752-o6atz33c	113	1	This	this	DT
cord-339752-o6atz33c	113	2	evidence	evidence	NN
cord-339752-o6atz33c	113	3	suggests	suggest	VBZ
cord-339752-o6atz33c	113	4	that	that	IN
cord-339752-o6atz33c	113	5	SARS	SARS	NNP
cord-339752-o6atz33c	113	6	-	-	HYPH
cord-339752-o6atz33c	113	7	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	113	8	invades	invade	VBZ
cord-339752-o6atz33c	113	9	the	the	DT
cord-339752-o6atz33c	113	10	human	human	JJ
cord-339752-o6atz33c	113	11	body	body	NN
cord-339752-o6atz33c	113	12	mostly	mostly	RB
cord-339752-o6atz33c	113	13	through	through	IN
cord-339752-o6atz33c	113	14	the	the	DT
cord-339752-o6atz33c	113	15	respiration	respiration	NN
cord-339752-o6atz33c	113	16	system	system	NN
cord-339752-o6atz33c	113	17	,	,	,
cord-339752-o6atz33c	113	18	and	and	CC
cord-339752-o6atz33c	113	19	possibly	possibly	RB
cord-339752-o6atz33c	113	20	also	also	RB
cord-339752-o6atz33c	113	21	through	through	IN
cord-339752-o6atz33c	113	22	the	the	DT
cord-339752-o6atz33c	113	23	intestine	intestine	NN
cord-339752-o6atz33c	113	24	and	and	CC
cord-339752-o6atz33c	113	25	other	other	JJ
cord-339752-o6atz33c	113	26	tissues	tissue	NNS
cord-339752-o6atz33c	113	27	.	.	.
cord-339752-o6atz33c	114	1	In	in	IN
cord-339752-o6atz33c	114	2	2004	2004	CD
cord-339752-o6atz33c	114	3	,	,	,
cord-339752-o6atz33c	114	4	Ding	Ding	NNP
cord-339752-o6atz33c	114	5	et	et	FW
cord-339752-o6atz33c	114	6	al	al	NNP
cord-339752-o6atz33c	114	7	.	.	NNP
cord-339752-o6atz33c	114	8	detected	detect	VBD
cord-339752-o6atz33c	114	9	organ	organ	NN
cord-339752-o6atz33c	114	10	distribution	distribution	NN
cord-339752-o6atz33c	114	11	of	of	IN
cord-339752-o6atz33c	114	12	SARS	SARS	NNP
cord-339752-o6atz33c	114	13	-	-	HYPH
cord-339752-o6atz33c	114	14	CoV	CoV	NNP
cord-339752-o6atz33c	114	15	by	by	IN
cord-339752-o6atz33c	114	16	immunohistochemistry	immunohistochemistry	NN
cord-339752-o6atz33c	114	17	and	and	CC
cord-339752-o6atz33c	114	18	in	in	IN
cord-339752-o6atz33c	114	19	situ	situ	JJ
cord-339752-o6atz33c	114	20	hybridization	hybridization	NN
cord-339752-o6atz33c	114	21	.	.	.
cord-339752-o6atz33c	115	1	SARS	SARS	NNP
cord-339752-o6atz33c	115	2	-	-	HYPH
cord-339752-o6atz33c	115	3	CoV	CoV	NNP
cord-339752-o6atz33c	115	4	was	be	VBD
cord-339752-o6atz33c	115	5	mainly	mainly	RB
cord-339752-o6atz33c	115	6	found	find	VBN
cord-339752-o6atz33c	115	7	in	in	IN
cord-339752-o6atz33c	115	8	the	the	DT
cord-339752-o6atz33c	115	9	respiratory	respiratory	JJ
cord-339752-o6atz33c	115	10	system	system	NN
cord-339752-o6atz33c	115	11	,	,	,
cord-339752-o6atz33c	115	12	stomach	stomach	NN
cord-339752-o6atz33c	115	13	,	,	,
cord-339752-o6atz33c	115	14	small	small	JJ
cord-339752-o6atz33c	115	15	intestine	intestine	NN
cord-339752-o6atz33c	115	16	,	,	,
cord-339752-o6atz33c	115	17	kidneys	kidney	NNS
cord-339752-o6atz33c	115	18	,	,	,
cord-339752-o6atz33c	115	19	and	and	CC
cord-339752-o6atz33c	115	20	sweat	sweat	NN
cord-339752-o6atz33c	115	21	glands	gland	NNS
cord-339752-o6atz33c	115	22	[	[	-LRB-
cord-339752-o6atz33c	115	23	44	44	CD
cord-339752-o6atz33c	115	24	]	]	-RRB-
cord-339752-o6atz33c	115	25	.	.	.
cord-339752-o6atz33c	116	1	The	the	DT
cord-339752-o6atz33c	116	2	organ	organ	NN
cord-339752-o6atz33c	116	3	distribution	distribution	NN
cord-339752-o6atz33c	116	4	of	of	IN
cord-339752-o6atz33c	116	5	SARS	SARS	NNP
cord-339752-o6atz33c	116	6	-	-	HYPH
cord-339752-o6atz33c	116	7	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	116	8	is	be	VBZ
cord-339752-o6atz33c	116	9	probably	probably	RB
cord-339752-o6atz33c	116	10	similar	similar	JJ
cord-339752-o6atz33c	116	11	to	to	IN
cord-339752-o6atz33c	116	12	SARS	SARS	NNP
cord-339752-o6atz33c	116	13	-	-	HYPH
cord-339752-o6atz33c	116	14	CoV.	CoV.	NNP
cord-339752-o6atz33c	117	1	Based	base	VBN
cord-339752-o6atz33c	117	2	on	on	IN
cord-339752-o6atz33c	117	3	the	the	DT
cord-339752-o6atz33c	117	4	evidence	evidence	NN
cord-339752-o6atz33c	117	5	described	describe	VBN
cord-339752-o6atz33c	117	6	above	above	RB
cord-339752-o6atz33c	117	7	,	,	,
cord-339752-o6atz33c	117	8	we	-PRON-	PRP
cord-339752-o6atz33c	117	9	hypothesize	hypothesize	VBP
cord-339752-o6atz33c	117	10	that	that	IN
cord-339752-o6atz33c	117	11	SARS	SARS	NNP
cord-339752-o6atz33c	117	12	-	-	HYPH
cord-339752-o6atz33c	117	13	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	117	14	invades	invade	VBZ
cord-339752-o6atz33c	117	15	the	the	DT
cord-339752-o6atz33c	117	16	lungs	lung	NNS
cord-339752-o6atz33c	117	17	and	and	CC
cord-339752-o6atz33c	117	18	intestine	intestine	NN
cord-339752-o6atz33c	117	19	through	through	IN
cord-339752-o6atz33c	117	20	TMPRSS2-cleaved	TMPRSS2-cleaved	NNP
cord-339752-o6atz33c	117	21	ACE2	ACE2	NNP
cord-339752-o6atz33c	117	22	.	.	.
cord-339752-o6atz33c	118	1	If	if	IN
cord-339752-o6atz33c	118	2	the	the	DT
cord-339752-o6atz33c	118	3	immune	immune	JJ
cord-339752-o6atz33c	118	4	system	system	NN
cord-339752-o6atz33c	118	5	is	be	VBZ
cord-339752-o6atz33c	118	6	not	not	RB
cord-339752-o6atz33c	118	7	able	able	JJ
cord-339752-o6atz33c	118	8	to	to	TO
cord-339752-o6atz33c	118	9	defeat	defeat	VB
cord-339752-o6atz33c	118	10	the	the	DT
cord-339752-o6atz33c	118	11	infection	infection	NN
cord-339752-o6atz33c	118	12	,	,	,
cord-339752-o6atz33c	118	13	SARS	SARS	NNP
cord-339752-o6atz33c	118	14	-	-	HYPH
cord-339752-o6atz33c	118	15	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	118	16	will	will	MD
cord-339752-o6atz33c	118	17	be	be	VB
cord-339752-o6atz33c	118	18	massively	massively	RB
cord-339752-o6atz33c	118	19	replicated	replicate	VBN
cord-339752-o6atz33c	118	20	,	,	,
cord-339752-o6atz33c	118	21	occupy	occupy	VB
cord-339752-o6atz33c	118	22	cellular	cellular	JJ
cord-339752-o6atz33c	118	23	ACE2	ACE2	NNP
cord-339752-o6atz33c	118	24	,	,	,
cord-339752-o6atz33c	118	25	and	and	CC
cord-339752-o6atz33c	118	26	destroy	destroy	VB
cord-339752-o6atz33c	118	27	the	the	DT
cord-339752-o6atz33c	118	28	host	host	NN
cord-339752-o6atz33c	118	29	's	's	POS
cord-339752-o6atz33c	118	30	cells	cell	NNS
cord-339752-o6atz33c	118	31	.	.	.
cord-339752-o6atz33c	119	1	As	as	IN
cord-339752-o6atz33c	119	2	a	a	DT
cord-339752-o6atz33c	119	3	consequence	consequence	NN
cord-339752-o6atz33c	119	4	,	,	,
cord-339752-o6atz33c	119	5	the	the	DT
cord-339752-o6atz33c	119	6	Ang	Ang	NNP
cord-339752-o6atz33c	119	7	II	II	NNP
cord-339752-o6atz33c	119	8	-	-	HYPH
cord-339752-o6atz33c	119	9	AT	AT	NNP
cord-339752-o6atz33c	119	10	1	1	CD
cord-339752-o6atz33c	119	11	signaling	signaling	NN
cord-339752-o6atz33c	119	12	can	can	MD
cord-339752-o6atz33c	119	13	not	not	RB
cord-339752-o6atz33c	119	14	be	be	VB
cord-339752-o6atz33c	119	15	inactive	inactive	JJ
cord-339752-o6atz33c	119	16	.	.	.
cord-339752-o6atz33c	120	1	Together	together	RB
cord-339752-o6atz33c	120	2	,	,	,
cord-339752-o6atz33c	120	3	the	the	DT
cord-339752-o6atz33c	120	4	intestinal	intestinal	JJ
cord-339752-o6atz33c	120	5	function	function	NN
cord-339752-o6atz33c	120	6	is	be	VBZ
cord-339752-o6atz33c	120	7	ruined	ruin	VBN
cord-339752-o6atz33c	120	8	and	and	CC
cord-339752-o6atz33c	120	9	the	the	DT
cord-339752-o6atz33c	120	10	inflammation	inflammation	NN
cord-339752-o6atz33c	120	11	exacerbated	exacerbate	VBD
cord-339752-o6atz33c	120	12	.	.	.
cord-339752-o6atz33c	121	1	As	as	IN
cord-339752-o6atz33c	121	2	a	a	DT
cord-339752-o6atz33c	121	3	result	result	NN
cord-339752-o6atz33c	121	4	,	,	,
cord-339752-o6atz33c	121	5	a	a	DT
cord-339752-o6atz33c	121	6	cytokine	cytokine	NN
cord-339752-o6atz33c	121	7	storm	storm	NN
cord-339752-o6atz33c	121	8	occurs	occur	VBZ
cord-339752-o6atz33c	121	9	and	and	CC
cord-339752-o6atz33c	121	10	eventually	eventually	RB
cord-339752-o6atz33c	121	11	the	the	DT
cord-339752-o6atz33c	121	12	respiration	respiration	NN
cord-339752-o6atz33c	121	13	system	system	NN
cord-339752-o6atz33c	121	14	,	,	,
cord-339752-o6atz33c	121	15	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	121	16	system	system	NN
cord-339752-o6atz33c	121	17	and	and	CC
cord-339752-o6atz33c	121	18	other	other	JJ
cord-339752-o6atz33c	121	19	organs	organ	NNS
cord-339752-o6atz33c	121	20	lose	lose	VBP
cord-339752-o6atz33c	121	21	function	function	NN
cord-339752-o6atz33c	121	22	(	(	-LRB-
cord-339752-o6atz33c	121	23	Figure	figure	NN
cord-339752-o6atz33c	121	24	3	3	CD
cord-339752-o6atz33c	121	25	)	)	-RRB-
cord-339752-o6atz33c	121	26	.	.	.
cord-339752-o6atz33c	122	1	Clinical	clinical	JJ
cord-339752-o6atz33c	122	2	data	datum	NNS
cord-339752-o6atz33c	122	3	showed	show	VBD
cord-339752-o6atz33c	122	4	that	that	IN
cord-339752-o6atz33c	122	5	among	among	IN
cord-339752-o6atz33c	122	6	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	122	7	inpatients	inpatient	NNS
cord-339752-o6atz33c	122	8	,	,	,
cord-339752-o6atz33c	122	9	about	about	RB
cord-339752-o6atz33c	122	10	30	30	CD
cord-339752-o6atz33c	122	11	%	%	NN
cord-339752-o6atz33c	122	12	have	have	VBP
cord-339752-o6atz33c	122	13	underlying	underlie	VBG
cord-339752-o6atz33c	122	14	diseases	disease	NNS
cord-339752-o6atz33c	122	15	.	.	.
cord-339752-o6atz33c	123	1	These	these	DT
cord-339752-o6atz33c	123	2	patients	patient	NNS
cord-339752-o6atz33c	123	3	have	have	VBP
cord-339752-o6atz33c	123	4	an	an	DT
cord-339752-o6atz33c	123	5	increased	increase	VBN
cord-339752-o6atz33c	123	6	risk	risk	NN
cord-339752-o6atz33c	123	7	of	of	IN
cord-339752-o6atz33c	123	8	death	death	NN
cord-339752-o6atz33c	123	9	.	.	.
cord-339752-o6atz33c	124	1	Hypertension	hypertension	NN
cord-339752-o6atz33c	124	2	was	be	VBD
cord-339752-o6atz33c	124	3	the	the	DT
cord-339752-o6atz33c	124	4	most	most	RBS
cord-339752-o6atz33c	124	5	common	common	JJ
cord-339752-o6atz33c	124	6	,	,	,
cord-339752-o6atz33c	124	7	followed	follow	VBN
cord-339752-o6atz33c	124	8	by	by	IN
cord-339752-o6atz33c	124	9	diabetes	diabetes	NN
cord-339752-o6atz33c	124	10	and	and	CC
cord-339752-o6atz33c	124	11	coronary	coronary	JJ
cord-339752-o6atz33c	124	12	heart	heart	NN
cord-339752-o6atz33c	124	13	disease	disease	NN
cord-339752-o6atz33c	124	14	[	[	-LRB-
cord-339752-o6atz33c	124	15	21	21	CD
cord-339752-o6atz33c	124	16	,	,	,
cord-339752-o6atz33c	124	17	45	45	CD
cord-339752-o6atz33c	124	18	]	]	-RRB-
cord-339752-o6atz33c	124	19	.	.	.
cord-339752-o6atz33c	125	1	Since	since	IN
cord-339752-o6atz33c	125	2	the	the	DT
cord-339752-o6atz33c	125	3	Ang	Ang	NNP
cord-339752-o6atz33c	125	4	II	II	NNP
cord-339752-o6atz33c	125	5	-	-	HYPH
cord-339752-o6atz33c	125	6	AT	AT	NNP
cord-339752-o6atz33c	125	7	1	1	CD
cord-339752-o6atz33c	125	8	axis	axis	NN
cord-339752-o6atz33c	125	9	is	be	VBZ
cord-339752-o6atz33c	125	10	hyperactive	hyperactive	JJ
cord-339752-o6atz33c	125	11	in	in	IN
cord-339752-o6atz33c	125	12	these	these	DT
cord-339752-o6atz33c	125	13	diseases	disease	NNS
cord-339752-o6atz33c	125	14	already	already	RB
cord-339752-o6atz33c	125	15	[	[	-LRB-
cord-339752-o6atz33c	125	16	46	46	CD
cord-339752-o6atz33c	125	17	,	,	,
cord-339752-o6atz33c	125	18	47	47	CD
cord-339752-o6atz33c	125	19	]	]	-RRB-
cord-339752-o6atz33c	125	20	,	,	,
cord-339752-o6atz33c	125	21	SARS	SARS	NNP
cord-339752-o6atz33c	125	22	-	-	HYPH
cord-339752-o6atz33c	125	23	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	125	24	further	further	RB
cord-339752-o6atz33c	125	25	decreases	decrease	VBZ
cord-339752-o6atz33c	125	26	the	the	DT
cord-339752-o6atz33c	125	27	production	production	NN
cord-339752-o6atz33c	125	28	of	of	IN
cord-339752-o6atz33c	125	29	functional	functional	JJ
cord-339752-o6atz33c	125	30	ACE2	ACE2	NNP
cord-339752-o6atz33c	125	31	.	.	.
cord-339752-o6atz33c	126	1	Therefore	therefore	RB
cord-339752-o6atz33c	126	2	,	,	,
cord-339752-o6atz33c	126	3	in	in	IN
cord-339752-o6atz33c	126	4	patients	patient	NNS
cord-339752-o6atz33c	126	5	with	with	IN
cord-339752-o6atz33c	126	6	those	those	DT
cord-339752-o6atz33c	126	7	underlying	underlie	VBG
cord-339752-o6atz33c	126	8	diseases	disease	NNS
cord-339752-o6atz33c	126	9	it	-PRON-	PRP
cord-339752-o6atz33c	126	10	is	be	VBZ
cord-339752-o6atz33c	126	11	much	much	RB
cord-339752-o6atz33c	126	12	easier	easy	JJR
cord-339752-o6atz33c	126	13	to	to	TO
cord-339752-o6atz33c	126	14	develop	develop	VB
cord-339752-o6atz33c	126	15	severe	severe	JJ
cord-339752-o6atz33c	126	16	and	and	CC
cord-339752-o6atz33c	126	17	critical	critical	JJ
cord-339752-o6atz33c	126	18	conditions	condition	NNS
cord-339752-o6atz33c	126	19	.	.	.
cord-339752-o6atz33c	127	1	Cellular	cellular	JJ
cord-339752-o6atz33c	127	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	127	3	can	can	MD
cord-339752-o6atz33c	127	4	be	be	VB
cord-339752-o6atz33c	127	5	shed	shed	VBN
cord-339752-o6atz33c	127	6	by	by	IN
cord-339752-o6atz33c	127	7	both	both	DT
cord-339752-o6atz33c	127	8	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	127	9	and	and	CC
cord-339752-o6atz33c	127	10	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	127	11	.	.	.
cord-339752-o6atz33c	128	1	The	the	DT
cord-339752-o6atz33c	128	2	ADAM17-cleavage	adam17-cleavage	NN
cord-339752-o6atz33c	128	3	is	be	VBZ
cord-339752-o6atz33c	128	4	a	a	DT
cord-339752-o6atz33c	128	5	normal	normal	JJ
cord-339752-o6atz33c	128	6	path	path	NN
cord-339752-o6atz33c	128	7	which	which	WDT
cord-339752-o6atz33c	128	8	results	result	VBZ
cord-339752-o6atz33c	128	9	in	in	IN
cord-339752-o6atz33c	128	10	the	the	DT
cord-339752-o6atz33c	128	11	production	production	NN
cord-339752-o6atz33c	128	12	of	of	IN
cord-339752-o6atz33c	128	13	circulating	circulate	VBG
cord-339752-o6atz33c	128	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	128	15	.	.	.
cord-339752-o6atz33c	129	1	Circulating	circulate	VBG
cord-339752-o6atz33c	129	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	129	3	can	can	MD
cord-339752-o6atz33c	129	4	prevent	prevent	VB
cord-339752-o6atz33c	129	5	severe	severe	JJ
cord-339752-o6atz33c	129	6	pathological	pathological	JJ
cord-339752-o6atz33c	129	7	conditions	condition	NNS
cord-339752-o6atz33c	129	8	and	and	CC
cord-339752-o6atz33c	129	9	protect	protect	VB
cord-339752-o6atz33c	129	10	organs	organ	NNS
cord-339752-o6atz33c	129	11	during	during	IN
cord-339752-o6atz33c	129	12	SARS	SARS	NNP
cord-339752-o6atz33c	129	13	-	-	HYPH
cord-339752-o6atz33c	129	14	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	129	15	infection	infection	NN
cord-339752-o6atz33c	129	16	.	.	.
cord-339752-o6atz33c	130	1	In	in	IN
cord-339752-o6atz33c	130	2	contrast	contrast	NN
cord-339752-o6atz33c	130	3	,	,	,
cord-339752-o6atz33c	130	4	TMPRSS2-shed	TMPRSS2-shed	NNP
cord-339752-o6atz33c	130	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	130	6	allows	allow	VBZ
cord-339752-o6atz33c	130	7	the	the	DT
cord-339752-o6atz33c	130	8	SARS	SARS	NNP
cord-339752-o6atz33c	130	9	-	-	HYPH
cord-339752-o6atz33c	130	10	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	130	11	to	to	TO
cord-339752-o6atz33c	130	12	invade	invade	VB
cord-339752-o6atz33c	130	13	cells	cell	NNS
cord-339752-o6atz33c	130	14	in	in	IN
cord-339752-o6atz33c	130	15	the	the	DT
cord-339752-o6atz33c	130	16	lungs	lung	NNS
cord-339752-o6atz33c	130	17	and	and	CC
cord-339752-o6atz33c	130	18	intestine	intestine	NN
cord-339752-o6atz33c	130	19	.	.	.
cord-339752-o6atz33c	131	1	TMPRSS2-cleavage	tmprss2-cleavage	CD
cord-339752-o6atz33c	131	2	path	path	NN
cord-339752-o6atz33c	131	3	might	may	MD
cord-339752-o6atz33c	131	4	inhibit	inhibit	VB
cord-339752-o6atz33c	131	5	ADAM17-cleavage	adam17-cleavage	NN
cord-339752-o6atz33c	131	6	path	path	NN
cord-339752-o6atz33c	131	7	.	.	.
cord-339752-o6atz33c	132	1	If	if	IN
cord-339752-o6atz33c	132	2	the	the	DT
cord-339752-o6atz33c	132	3	immune	immune	JJ
cord-339752-o6atz33c	132	4	system	system	NN
cord-339752-o6atz33c	132	5	is	be	VBZ
cord-339752-o6atz33c	132	6	not	not	RB
cord-339752-o6atz33c	132	7	able	able	JJ
cord-339752-o6atz33c	132	8	to	to	TO
cord-339752-o6atz33c	132	9	defeat	defeat	VB
cord-339752-o6atz33c	132	10	the	the	DT
cord-339752-o6atz33c	132	11	virus	virus	NN
cord-339752-o6atz33c	132	12	,	,	,
cord-339752-o6atz33c	132	13	SARS	SARS	NNP
cord-339752-o6atz33c	132	14	-	-	HYPH
cord-339752-o6atz33c	132	15	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	132	16	will	will	MD
cord-339752-o6atz33c	132	17	be	be	VB
cord-339752-o6atz33c	132	18	massively	massively	RB
cord-339752-o6atz33c	132	19	reproduced	reproduce	VBN
cord-339752-o6atz33c	132	20	,	,	,
cord-339752-o6atz33c	132	21	occupy	occupy	VB
cord-339752-o6atz33c	132	22	cellular	cellular	JJ
cord-339752-o6atz33c	132	23	ACE2	ACE2	NNP
cord-339752-o6atz33c	132	24	,	,	,
cord-339752-o6atz33c	132	25	and	and	CC
cord-339752-o6atz33c	132	26	destroy	destroy	VB
cord-339752-o6atz33c	132	27	the	the	DT
cord-339752-o6atz33c	132	28	host	host	NN
cord-339752-o6atz33c	132	29	's	's	POS
cord-339752-o6atz33c	132	30	cells	cell	NNS
cord-339752-o6atz33c	132	31	in	in	IN
cord-339752-o6atz33c	132	32	the	the	DT
cord-339752-o6atz33c	132	33	lungs	lung	NNS
cord-339752-o6atz33c	132	34	and	and	CC
cord-339752-o6atz33c	132	35	intestine	intestine	NN
cord-339752-o6atz33c	132	36	.	.	.
cord-339752-o6atz33c	133	1	As	as	IN
cord-339752-o6atz33c	133	2	SARS	SARS	NNP
cord-339752-o6atz33c	133	3	-	-	HYPH
cord-339752-o6atz33c	133	4	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	133	5	reduces	reduce	VBZ
cord-339752-o6atz33c	133	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	133	7	expression	expression	NN
cord-339752-o6atz33c	133	8	,	,	,
cord-339752-o6atz33c	133	9	there	there	EX
cord-339752-o6atz33c	133	10	is	be	VBZ
cord-339752-o6atz33c	133	11	not	not	RB
cord-339752-o6atz33c	133	12	enough	enough	JJ
cord-339752-o6atz33c	133	13	ADAM17-shed	adam17-shed	NN
cord-339752-o6atz33c	133	14	circulating	circulate	VBG
cord-339752-o6atz33c	133	15	ACE2	ACE2	NNP
cord-339752-o6atz33c	133	16	against	against	IN
cord-339752-o6atz33c	133	17	the	the	DT
cord-339752-o6atz33c	133	18	Ang	Ang	NNP
cord-339752-o6atz33c	133	19	II	II	NNP
cord-339752-o6atz33c	133	20	signaling	signal	VBG
cord-339752-o6atz33c	133	21	-	-	HYPH
cord-339752-o6atz33c	133	22	induced	induce	VBN
cord-339752-o6atz33c	133	23	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	133	24	injuries	injury	NNS
cord-339752-o6atz33c	133	25	,	,	,
cord-339752-o6atz33c	133	26	and	and	CC
cord-339752-o6atz33c	133	27	inflammation	inflammation	NN
cord-339752-o6atz33c	133	28	is	be	VBZ
cord-339752-o6atz33c	133	29	accelerated	accelerate	VBN
cord-339752-o6atz33c	133	30	until	until	IN
cord-339752-o6atz33c	133	31	the	the	DT
cord-339752-o6atz33c	133	32	immune	immune	JJ
cord-339752-o6atz33c	133	33	system	system	NN
cord-339752-o6atz33c	133	34	is	be	VBZ
cord-339752-o6atz33c	133	35	overwhelmed	overwhelmed	JJ
cord-339752-o6atz33c	133	36	.	.	.
cord-339752-o6atz33c	134	1	Meanwhile	meanwhile	RB
cord-339752-o6atz33c	134	2	,	,	,
cord-339752-o6atz33c	134	3	cellular	cellular	JJ
cord-339752-o6atz33c	134	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	134	5	/	/	SYM
cord-339752-o6atz33c	134	6	B	b	NN
cord-339752-o6atz33c	134	7	0	0	CD
cord-339752-o6atz33c	134	8	AT1	at1	NN
cord-339752-o6atz33c	134	9	in	in	IN
cord-339752-o6atz33c	134	10	the	the	DT
cord-339752-o6atz33c	134	11	intestine	intestine	NN
cord-339752-o6atz33c	134	12	is	be	VBZ
cord-339752-o6atz33c	134	13	ruined	ruin	VBN
cord-339752-o6atz33c	134	14	by	by	IN
cord-339752-o6atz33c	134	15	the	the	DT
cord-339752-o6atz33c	134	16	virus	virus	NN
cord-339752-o6atz33c	134	17	.	.	.
cord-339752-o6atz33c	135	1	Essential	essential	JJ
cord-339752-o6atz33c	135	2	amino	amino	NN
cord-339752-o6atz33c	135	3	acids	acid	NNS
cord-339752-o6atz33c	135	4	can	can	MD
cord-339752-o6atz33c	135	5	not	not	RB
cord-339752-o6atz33c	135	6	be	be	VB
cord-339752-o6atz33c	135	7	absorbed	absorb	VBN
cord-339752-o6atz33c	135	8	,	,	,
cord-339752-o6atz33c	135	9	the	the	DT
cord-339752-o6atz33c	135	10	antimicrobial	antimicrobial	JJ
cord-339752-o6atz33c	135	11	peptides	peptide	NNS
cord-339752-o6atz33c	135	12	are	be	VBP
cord-339752-o6atz33c	135	13	reduced	reduce	VBN
cord-339752-o6atz33c	135	14	,	,	,
cord-339752-o6atz33c	135	15	and	and	CC
cord-339752-o6atz33c	135	16	the	the	DT
cord-339752-o6atz33c	135	17	ecology	ecology	NN
cord-339752-o6atz33c	135	18	of	of	IN
cord-339752-o6atz33c	135	19	the	the	DT
cord-339752-o6atz33c	135	20	gut	gut	NN
cord-339752-o6atz33c	135	21	microbiome	microbiome	NN
cord-339752-o6atz33c	135	22	is	be	VBZ
cord-339752-o6atz33c	135	23	damaged	damage	VBN
cord-339752-o6atz33c	135	24	.	.	.
cord-339752-o6atz33c	136	1	These	these	DT
cord-339752-o6atz33c	136	2	intestinal	intestinal	JJ
cord-339752-o6atz33c	136	3	changes	change	NNS
cord-339752-o6atz33c	136	4	will	will	MD
cord-339752-o6atz33c	136	5	precipitate	precipitate	VB
cord-339752-o6atz33c	136	6	inflammation	inflammation	NN
cord-339752-o6atz33c	136	7	.	.	.
cord-339752-o6atz33c	137	1	As	as	IN
cord-339752-o6atz33c	137	2	a	a	DT
cord-339752-o6atz33c	137	3	result	result	NN
cord-339752-o6atz33c	137	4	,	,	,
cord-339752-o6atz33c	137	5	a	a	DT
cord-339752-o6atz33c	137	6	cytokine	cytokine	NN
cord-339752-o6atz33c	137	7	storm	storm	NN
cord-339752-o6atz33c	137	8	occurs	occur	VBZ
cord-339752-o6atz33c	137	9	and	and	CC
cord-339752-o6atz33c	137	10	eventually	eventually	RB
cord-339752-o6atz33c	137	11	induces	induce	VBZ
cord-339752-o6atz33c	137	12	multiple	multiple	JJ
cord-339752-o6atz33c	137	13	organ	organ	NN
cord-339752-o6atz33c	137	14	dysfunction	dysfunction	NN
cord-339752-o6atz33c	137	15	or	or	CC
cord-339752-o6atz33c	137	16	failure	failure	NN
cord-339752-o6atz33c	137	17	.	.	.
cord-339752-o6atz33c	138	1	Cellular	cellular	JJ
cord-339752-o6atz33c	138	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	138	3	can	can	MD
cord-339752-o6atz33c	138	4	be	be	VB
cord-339752-o6atz33c	138	5	shed	shed	VBN
cord-339752-o6atz33c	138	6	by	by	IN
cord-339752-o6atz33c	138	7	both	both	DT
cord-339752-o6atz33c	138	8	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	138	9	and	and	CC
cord-339752-o6atz33c	138	10	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	138	11	.	.	.
cord-339752-o6atz33c	139	1	The	the	DT
cord-339752-o6atz33c	139	2	ADAM17-cleavage	adam17-cleavage	NN
cord-339752-o6atz33c	139	3	is	be	VBZ
cord-339752-o6atz33c	139	4	a	a	DT
cord-339752-o6atz33c	139	5	normal	normal	JJ
cord-339752-o6atz33c	139	6	path	path	NN
cord-339752-o6atz33c	139	7	which	which	WDT
cord-339752-o6atz33c	139	8	results	result	VBZ
cord-339752-o6atz33c	139	9	in	in	IN
cord-339752-o6atz33c	139	10	the	the	DT
cord-339752-o6atz33c	139	11	production	production	NN
cord-339752-o6atz33c	139	12	of	of	IN
cord-339752-o6atz33c	139	13	circulating	circulate	VBG
cord-339752-o6atz33c	139	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	139	15	.	.	.
cord-339752-o6atz33c	140	1	Circulating	circulate	VBG
cord-339752-o6atz33c	140	2	ACE2	ACE2	NNP
cord-339752-o6atz33c	140	3	can	can	MD
cord-339752-o6atz33c	140	4	prevent	prevent	VB
cord-339752-o6atz33c	140	5	severe	severe	JJ
cord-339752-o6atz33c	140	6	pathological	pathological	JJ
cord-339752-o6atz33c	140	7	conditions	condition	NNS
cord-339752-o6atz33c	140	8	and	and	CC
cord-339752-o6atz33c	140	9	protect	protect	VB
cord-339752-o6atz33c	140	10	organs	organ	NNS
cord-339752-o6atz33c	140	11	during	during	IN
cord-339752-o6atz33c	140	12	SARS	SARS	NNP
cord-339752-o6atz33c	140	13	-	-	HYPH
cord-339752-o6atz33c	140	14	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	140	15	infection	infection	NN
cord-339752-o6atz33c	140	16	.	.	.
cord-339752-o6atz33c	141	1	In	in	IN
cord-339752-o6atz33c	141	2	contrast	contrast	NN
cord-339752-o6atz33c	141	3	,	,	,
cord-339752-o6atz33c	141	4	TMPRSS2-shed	TMPRSS2-shed	NNP
cord-339752-o6atz33c	141	5	ACE2	ACE2	NNP
cord-339752-o6atz33c	141	6	allows	allow	VBZ
cord-339752-o6atz33c	141	7	the	the	DT
cord-339752-o6atz33c	141	8	SARS	SARS	NNP
cord-339752-o6atz33c	141	9	-	-	HYPH
cord-339752-o6atz33c	141	10	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	141	11	to	to	TO
cord-339752-o6atz33c	141	12	invade	invade	VB
cord-339752-o6atz33c	141	13	cells	cell	NNS
cord-339752-o6atz33c	141	14	in	in	IN
cord-339752-o6atz33c	141	15	the	the	DT
cord-339752-o6atz33c	141	16	lungs	lung	NNS
cord-339752-o6atz33c	141	17	and	and	CC
cord-339752-o6atz33c	141	18	intestine	intestine	NN
cord-339752-o6atz33c	141	19	.	.	.
cord-339752-o6atz33c	142	1	TMPRSS2-cleavage	tmprss2-cleavage	CD
cord-339752-o6atz33c	142	2	path	path	NN
cord-339752-o6atz33c	142	3	might	may	MD
cord-339752-o6atz33c	142	4	inhibit	inhibit	VB
cord-339752-o6atz33c	142	5	ADAM17-cleavage	adam17-cleavage	NN
cord-339752-o6atz33c	142	6	path	path	NN
cord-339752-o6atz33c	142	7	.	.	.
cord-339752-o6atz33c	143	1	If	if	IN
cord-339752-o6atz33c	143	2	the	the	DT
cord-339752-o6atz33c	143	3	immune	immune	JJ
cord-339752-o6atz33c	143	4	system	system	NN
cord-339752-o6atz33c	143	5	is	be	VBZ
cord-339752-o6atz33c	143	6	not	not	RB
cord-339752-o6atz33c	143	7	able	able	JJ
cord-339752-o6atz33c	143	8	to	to	TO
cord-339752-o6atz33c	143	9	defeat	defeat	VB
cord-339752-o6atz33c	143	10	the	the	DT
cord-339752-o6atz33c	143	11	virus	virus	NN
cord-339752-o6atz33c	143	12	,	,	,
cord-339752-o6atz33c	143	13	SARS	SARS	NNP
cord-339752-o6atz33c	143	14	-	-	HYPH
cord-339752-o6atz33c	143	15	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	143	16	will	will	MD
cord-339752-o6atz33c	143	17	be	be	VB
cord-339752-o6atz33c	143	18	massively	massively	RB
cord-339752-o6atz33c	143	19	reproduced	reproduce	VBN
cord-339752-o6atz33c	143	20	,	,	,
cord-339752-o6atz33c	143	21	occupy	occupy	VB
cord-339752-o6atz33c	143	22	cellular	cellular	JJ
cord-339752-o6atz33c	143	23	ACE2	ACE2	NNP
cord-339752-o6atz33c	143	24	,	,	,
cord-339752-o6atz33c	143	25	and	and	CC
cord-339752-o6atz33c	143	26	destroy	destroy	VB
cord-339752-o6atz33c	143	27	the	the	DT
cord-339752-o6atz33c	143	28	host	host	NN
cord-339752-o6atz33c	143	29	's	's	POS
cord-339752-o6atz33c	143	30	cells	cell	NNS
cord-339752-o6atz33c	143	31	in	in	IN
cord-339752-o6atz33c	143	32	the	the	DT
cord-339752-o6atz33c	143	33	lungs	lung	NNS
cord-339752-o6atz33c	143	34	and	and	CC
cord-339752-o6atz33c	143	35	intestine	intestine	NN
cord-339752-o6atz33c	143	36	.	.	.
cord-339752-o6atz33c	144	1	As	as	IN
cord-339752-o6atz33c	144	2	SARS	SARS	NNP
cord-339752-o6atz33c	144	3	-	-	HYPH
cord-339752-o6atz33c	144	4	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	144	5	reduces	reduce	VBZ
cord-339752-o6atz33c	144	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	144	7	expression	expression	NN
cord-339752-o6atz33c	144	8	,	,	,
cord-339752-o6atz33c	144	9	there	there	EX
cord-339752-o6atz33c	144	10	is	be	VBZ
cord-339752-o6atz33c	144	11	not	not	RB
cord-339752-o6atz33c	144	12	enough	enough	JJ
cord-339752-o6atz33c	144	13	ADAM17-shed	adam17-shed	NN
cord-339752-o6atz33c	144	14	circulating	circulate	VBG
cord-339752-o6atz33c	144	15	ACE2	ACE2	NNP
cord-339752-o6atz33c	144	16	against	against	IN
cord-339752-o6atz33c	144	17	the	the	DT
cord-339752-o6atz33c	144	18	Ang	Ang	NNP
cord-339752-o6atz33c	144	19	II	II	NNP
cord-339752-o6atz33c	144	20	signaling	signal	VBG
cord-339752-o6atz33c	144	21	-	-	HYPH
cord-339752-o6atz33c	144	22	induced	induce	VBN
cord-339752-o6atz33c	144	23	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	144	24	injuries	injury	NNS
cord-339752-o6atz33c	144	25	,	,	,
cord-339752-o6atz33c	144	26	and	and	CC
cord-339752-o6atz33c	144	27	inflammation	inflammation	NN
cord-339752-o6atz33c	144	28	is	be	VBZ
cord-339752-o6atz33c	144	29	accelerated	accelerate	VBN
cord-339752-o6atz33c	144	30	until	until	IN
cord-339752-o6atz33c	144	31	the	the	DT
cord-339752-o6atz33c	144	32	immune	immune	JJ
cord-339752-o6atz33c	144	33	system	system	NN
cord-339752-o6atz33c	144	34	is	be	VBZ
cord-339752-o6atz33c	144	35	overwhelmed	overwhelmed	JJ
cord-339752-o6atz33c	144	36	.	.	.
cord-339752-o6atz33c	145	1	Meanwhile	meanwhile	RB
cord-339752-o6atz33c	145	2	,	,	,
cord-339752-o6atz33c	145	3	cellular	cellular	JJ
cord-339752-o6atz33c	145	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	145	5	/	/	SYM
cord-339752-o6atz33c	145	6	B	b	NN
cord-339752-o6atz33c	145	7	0	0	CD
cord-339752-o6atz33c	145	8	AT1	at1	NN
cord-339752-o6atz33c	145	9	in	in	IN
cord-339752-o6atz33c	145	10	the	the	DT
cord-339752-o6atz33c	145	11	intestine	intestine	NN
cord-339752-o6atz33c	145	12	is	be	VBZ
cord-339752-o6atz33c	145	13	ruined	ruin	VBN
cord-339752-o6atz33c	145	14	by	by	IN
cord-339752-o6atz33c	145	15	the	the	DT
cord-339752-o6atz33c	145	16	virus	virus	NN
cord-339752-o6atz33c	145	17	.	.	.
cord-339752-o6atz33c	146	1	Essential	essential	JJ
cord-339752-o6atz33c	146	2	amino	amino	NN
cord-339752-o6atz33c	146	3	acids	acid	NNS
cord-339752-o6atz33c	146	4	can	can	MD
cord-339752-o6atz33c	146	5	not	not	RB
cord-339752-o6atz33c	146	6	be	be	VB
cord-339752-o6atz33c	146	7	absorbed	absorb	VBN
cord-339752-o6atz33c	146	8	,	,	,
cord-339752-o6atz33c	146	9	the	the	DT
cord-339752-o6atz33c	146	10	antimicrobial	antimicrobial	JJ
cord-339752-o6atz33c	146	11	peptides	peptide	NNS
cord-339752-o6atz33c	146	12	are	be	VBP
cord-339752-o6atz33c	146	13	reduced	reduce	VBN
cord-339752-o6atz33c	146	14	,	,	,
cord-339752-o6atz33c	146	15	and	and	CC
cord-339752-o6atz33c	146	16	the	the	DT
cord-339752-o6atz33c	146	17	ecology	ecology	NN
cord-339752-o6atz33c	146	18	of	of	IN
cord-339752-o6atz33c	146	19	the	the	DT
cord-339752-o6atz33c	146	20	gut	gut	NN
cord-339752-o6atz33c	146	21	microbiome	microbiome	NN
cord-339752-o6atz33c	146	22	is	be	VBZ
cord-339752-o6atz33c	146	23	damaged	damage	VBN
cord-339752-o6atz33c	146	24	.	.	.
cord-339752-o6atz33c	147	1	These	these	DT
cord-339752-o6atz33c	147	2	intestinal	intestinal	JJ
cord-339752-o6atz33c	147	3	changes	change	NNS
cord-339752-o6atz33c	147	4	will	will	MD
cord-339752-o6atz33c	147	5	precipitate	precipitate	VB
cord-339752-o6atz33c	147	6	inflammation	inflammation	NN
cord-339752-o6atz33c	147	7	.	.	.
cord-339752-o6atz33c	148	1	As	as	IN
cord-339752-o6atz33c	148	2	a	a	DT
cord-339752-o6atz33c	148	3	result	result	NN
cord-339752-o6atz33c	148	4	,	,	,
cord-339752-o6atz33c	148	5	a	a	DT
cord-339752-o6atz33c	148	6	cytokine	cytokine	NN
cord-339752-o6atz33c	148	7	storm	storm	NN
cord-339752-o6atz33c	148	8	occurs	occur	VBZ
cord-339752-o6atz33c	148	9	and	and	CC
cord-339752-o6atz33c	148	10	eventually	eventually	RB
cord-339752-o6atz33c	148	11	induces	induce	VBZ
cord-339752-o6atz33c	148	12	multiple	multiple	JJ
cord-339752-o6atz33c	148	13	organ	organ	NN
cord-339752-o6atz33c	148	14	dysfunction	dysfunction	NN
cord-339752-o6atz33c	148	15	or	or	CC
cord-339752-o6atz33c	148	16	failure	failure	NN
cord-339752-o6atz33c	148	17	.	.	.
cord-339752-o6atz33c	148	18	 	 	_SP
cord-339752-o6atz33c	149	1	As	as	IN
cord-339752-o6atz33c	149	2	addressed	address	VBN
cord-339752-o6atz33c	149	3	above	above	RB
cord-339752-o6atz33c	149	4	,	,	,
cord-339752-o6atz33c	149	5	the	the	DT
cord-339752-o6atz33c	149	6	strategies	strategy	NNS
cord-339752-o6atz33c	149	7	for	for	IN
cord-339752-o6atz33c	149	8	preventing	prevent	VBG
cord-339752-o6atz33c	149	9	and	and	CC
cord-339752-o6atz33c	149	10	reversing	reverse	VBG
cord-339752-o6atz33c	149	11	severe	severe	JJ
cord-339752-o6atz33c	149	12	and	and	CC
cord-339752-o6atz33c	149	13	critical	critical	JJ
cord-339752-o6atz33c	149	14	COVID-19	covid-19	NN
cord-339752-o6atz33c	149	15	should	should	MD
cord-339752-o6atz33c	149	16	include	include	VB
cord-339752-o6atz33c	149	17	:	:	:
cord-339752-o6atz33c	149	18	Since	since	IN
cord-339752-o6atz33c	149	19	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	149	20	plays	play	VBZ
cord-339752-o6atz33c	149	21	a	a	DT
cord-339752-o6atz33c	149	22	very	very	RB
cord-339752-o6atz33c	149	23	important	important	JJ
cord-339752-o6atz33c	149	24	role	role	NN
cord-339752-o6atz33c	149	25	in	in	IN
cord-339752-o6atz33c	149	26	SARS	SARS	NNP
cord-339752-o6atz33c	149	27	-	-	HYPH
cord-339752-o6atz33c	149	28	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	149	29	cell	cell	NN
cord-339752-o6atz33c	149	30	entry	entry	NN
cord-339752-o6atz33c	149	31	and	and	CC
cord-339752-o6atz33c	149	32	ACE2	ACE2	NNP
cord-339752-o6atz33c	149	33	dysfunction	dysfunction	NN
cord-339752-o6atz33c	149	34	,	,	,
cord-339752-o6atz33c	149	35	blocking	block	VBG
cord-339752-o6atz33c	149	36	the	the	DT
cord-339752-o6atz33c	149	37	activity	activity	NN
cord-339752-o6atz33c	149	38	of	of	IN
cord-339752-o6atz33c	149	39	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	149	40	should	should	MD
cord-339752-o6atz33c	149	41	be	be	VB
cord-339752-o6atz33c	149	42	the	the	DT
cord-339752-o6atz33c	149	43	primary	primary	JJ
cord-339752-o6atz33c	149	44	strategy	strategy	NN
cord-339752-o6atz33c	149	45	for	for	IN
cord-339752-o6atz33c	149	46	preventing	prevent	VBG
cord-339752-o6atz33c	149	47	severe	severe	JJ
cord-339752-o6atz33c	149	48	and	and	CC
cord-339752-o6atz33c	149	49	critical	critical	JJ
cord-339752-o6atz33c	149	50	conditions	condition	NNS
cord-339752-o6atz33c	149	51	of	of	IN
cord-339752-o6atz33c	149	52	COVID-19	covid-19	NN
cord-339752-o6atz33c	149	53	.	.	.
cord-339752-o6atz33c	150	1	Hoffmann	Hoffmann	NNP
cord-339752-o6atz33c	150	2	et	et	NNP
cord-339752-o6atz33c	150	3	al	al	NNP
cord-339752-o6atz33c	150	4	.	.	NNP
cord-339752-o6atz33c	150	5	discovered	discover	VBD
cord-339752-o6atz33c	150	6	that	that	IN
cord-339752-o6atz33c	150	7	a	a	DT
cord-339752-o6atz33c	150	8	serine	serine	JJ
cord-339752-o6atz33c	150	9	protease	protease	NN
cord-339752-o6atz33c	150	10	inhibitor	inhibitor	NN
cord-339752-o6atz33c	150	11	,	,	,
cord-339752-o6atz33c	150	12	camostat	camostat	NNP
cord-339752-o6atz33c	150	13	mesylate	mesylate	NNP
cord-339752-o6atz33c	150	14	,	,	,
cord-339752-o6atz33c	150	15	partially	partially	RB
cord-339752-o6atz33c	150	16	blocked	block	VBN
cord-339752-o6atz33c	150	17	TMPRSS2-ACE2-mediated	TMPRSS2-ACE2-mediated	NNP
cord-339752-o6atz33c	150	18	SARS	SARS	NNP
cord-339752-o6atz33c	150	19	-	-	HYPH
cord-339752-o6atz33c	150	20	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	150	21	entry	entry	NN
cord-339752-o6atz33c	150	22	[	[	-LRB-
cord-339752-o6atz33c	150	23	3	3	CD
cord-339752-o6atz33c	150	24	]	]	-RRB-
cord-339752-o6atz33c	150	25	.	.	.
cord-339752-o6atz33c	151	1	Similarly	similarly	RB
cord-339752-o6atz33c	151	2	,	,	,
cord-339752-o6atz33c	151	3	nafamostat	nafamostat	NNP
cord-339752-o6atz33c	151	4	mesylate	mesylate	NNP
cord-339752-o6atz33c	151	5	inhibited	inhibit	VBD
cord-339752-o6atz33c	151	6	the	the	DT
cord-339752-o6atz33c	151	7	TMPRSS2-ACE2-mediated	TMPRSS2-ACE2-mediated	NNP
cord-339752-o6atz33c	151	8	SARS	SARS	NNP
cord-339752-o6atz33c	151	9	-	-	HYPH
cord-339752-o6atz33c	151	10	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	151	11	envelope	envelope	NN
cord-339752-o6atz33c	151	12	-	-	HYPH
cord-339752-o6atz33c	151	13	plasma	plasma	NN
cord-339752-o6atz33c	151	14	membrane	membrane	NN
cord-339752-o6atz33c	151	15	fusion	fusion	NN
cord-339752-o6atz33c	151	16	,	,	,
cord-339752-o6atz33c	151	17	and	and	CC
cord-339752-o6atz33c	151	18	then	then	RB
cord-339752-o6atz33c	151	19	showed	show	VBD
cord-339752-o6atz33c	151	20	10	10	CD
cord-339752-o6atz33c	151	21	times	time	NNS
cord-339752-o6atz33c	151	22	higher	high	JJR
cord-339752-o6atz33c	151	23	efficiency	efficiency	NN
cord-339752-o6atz33c	151	24	than	than	IN
cord-339752-o6atz33c	151	25	camostat	camostat	NNP
cord-339752-o6atz33c	151	26	mesylate	mesylate	NNP
cord-339752-o6atz33c	151	27	in	in	IN
cord-339752-o6atz33c	151	28	preventing	prevent	VBG
cord-339752-o6atz33c	151	29	SARS	SARS	NNP
cord-339752-o6atz33c	151	30	-	-	HYPH
cord-339752-o6atz33c	151	31	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	151	32	cell	cell	NN
cord-339752-o6atz33c	151	33	entry	entry	NN
cord-339752-o6atz33c	151	34	[	[	-LRB-
cord-339752-o6atz33c	151	35	48	48	CD
cord-339752-o6atz33c	151	36	]	]	-RRB-
cord-339752-o6atz33c	151	37	.	.	.
cord-339752-o6atz33c	152	1	Both	both	DT
cord-339752-o6atz33c	152	2	camostat	camostat	NNP
cord-339752-o6atz33c	152	3	mesylate	mesylate	NNP
cord-339752-o6atz33c	152	4	and	and	CC
cord-339752-o6atz33c	152	5	nagamostat	nagamostat	NNP
cord-339752-o6atz33c	152	6	mesylate	mesylate	NNP
cord-339752-o6atz33c	152	7	are	be	VBP
cord-339752-o6atz33c	152	8	clinically	clinically	RB
cord-339752-o6atz33c	152	9	approved	approve	VBN
cord-339752-o6atz33c	152	10	medicines	medicine	NNS
cord-339752-o6atz33c	152	11	with	with	IN
cord-339752-o6atz33c	152	12	verified	verify	VBN
cord-339752-o6atz33c	152	13	safety	safety	NN
cord-339752-o6atz33c	152	14	,	,	,
cord-339752-o6atz33c	152	15	and	and	CC
cord-339752-o6atz33c	152	16	thus	thus	RB
cord-339752-o6atz33c	152	17	can	can	MD
cord-339752-o6atz33c	152	18	be	be	VB
cord-339752-o6atz33c	152	19	applied	apply	VBN
cord-339752-o6atz33c	152	20	for	for	IN
cord-339752-o6atz33c	152	21	COVID-19	covid-19	JJ
cord-339752-o6atz33c	152	22	treatment	treatment	NN
cord-339752-o6atz33c	152	23	in	in	IN
cord-339752-o6atz33c	152	24	clinical	clinical	JJ
cord-339752-o6atz33c	152	25	practices	practice	NNS
cord-339752-o6atz33c	152	26	immediately	immediately	RB
cord-339752-o6atz33c	152	27	.	.	.
cord-339752-o6atz33c	153	1	Nafamostat	Nafamostat	NNP
cord-339752-o6atz33c	153	2	mesylate	mesylate	NNP
cord-339752-o6atz33c	153	3	also	also	RB
cord-339752-o6atz33c	153	4	has	have	VBZ
cord-339752-o6atz33c	153	5	been	be	VBN
cord-339752-o6atz33c	153	6	used	use	VBN
cord-339752-o6atz33c	153	7	as	as	IN
cord-339752-o6atz33c	153	8	a	a	DT
cord-339752-o6atz33c	153	9	short	short	RB
cord-339752-o6atz33c	153	10	-	-	HYPH
cord-339752-o6atz33c	153	11	acting	act	VBG
cord-339752-o6atz33c	153	12	anticoagulant	anticoagulant	NN
cord-339752-o6atz33c	153	13	due	due	IN
cord-339752-o6atz33c	153	14	to	to	IN
cord-339752-o6atz33c	153	15	its	-PRON-	PRP$
cord-339752-o6atz33c	153	16	ability	ability	NN
cord-339752-o6atz33c	153	17	to	to	TO
cord-339752-o6atz33c	153	18	prevent	prevent	VB
cord-339752-o6atz33c	153	19	the	the	DT
cord-339752-o6atz33c	153	20	proteolysis	proteolysis	NN
cord-339752-o6atz33c	153	21	of	of	IN
cord-339752-o6atz33c	153	22	fibrinogen	fibrinogen	NN
cord-339752-o6atz33c	153	23	into	into	IN
cord-339752-o6atz33c	153	24	fibrin	fibrin	NN
cord-339752-o6atz33c	153	25	.	.	.
cord-339752-o6atz33c	154	1	Clinical	clinical	JJ
cord-339752-o6atz33c	154	2	reports	report	NNS
cord-339752-o6atz33c	154	3	of	of	IN
cord-339752-o6atz33c	154	4	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	154	5	showed	show	VBD
cord-339752-o6atz33c	154	6	that	that	IN
cord-339752-o6atz33c	154	7	increased	increase	VBN
cord-339752-o6atz33c	154	8	D	d	NN
cord-339752-o6atz33c	154	9	-	-	HYPH
cord-339752-o6atz33c	154	10	dimer	dimer	NN
cord-339752-o6atz33c	154	11	(	(	-LRB-
cord-339752-o6atz33c	154	12	a	a	DT
cord-339752-o6atz33c	154	13	fibrin	fibrin	NN
cord-339752-o6atz33c	154	14	degradation	degradation	NN
cord-339752-o6atz33c	154	15	product	product	NN
cord-339752-o6atz33c	154	16	)	)	-RRB-
cord-339752-o6atz33c	154	17	levels	level	NNS
cord-339752-o6atz33c	154	18	in	in	IN
cord-339752-o6atz33c	154	19	severe	severe	JJ
cord-339752-o6atz33c	154	20	and	and	CC
cord-339752-o6atz33c	154	21	critical	critical	JJ
cord-339752-o6atz33c	154	22	patients	patient	NNS
cord-339752-o6atz33c	154	23	were	be	VBD
cord-339752-o6atz33c	154	24	often	often	RB
cord-339752-o6atz33c	154	25	observed	observe	VBN
cord-339752-o6atz33c	154	26	[	[	-LRB-
cord-339752-o6atz33c	154	27	21	21	CD
cord-339752-o6atz33c	154	28	,	,	,
cord-339752-o6atz33c	154	29	49	49	CD
cord-339752-o6atz33c	154	30	,	,	,
cord-339752-o6atz33c	154	31	50	50	CD
cord-339752-o6atz33c	154	32	]	]	-RRB-
cord-339752-o6atz33c	154	33	.	.	.
cord-339752-o6atz33c	155	1	High	high	JJ
cord-339752-o6atz33c	155	2	levels	level	NNS
cord-339752-o6atz33c	155	3	of	of	IN
cord-339752-o6atz33c	155	4	D	d	NN
cord-339752-o6atz33c	155	5	-	-	HYPH
cord-339752-o6atz33c	155	6	dimer	dimer	NN
cord-339752-o6atz33c	155	7	(	(	-LRB-
cord-339752-o6atz33c	155	8	>	>	NFP
cord-339752-o6atz33c	155	9	1	1	CD
cord-339752-o6atz33c	155	10	µg	µg	NN
cord-339752-o6atz33c	155	11	/	/	SYM
cord-339752-o6atz33c	155	12	mL	ml	NN
cord-339752-o6atz33c	155	13	)	)	-RRB-
cord-339752-o6atz33c	155	14	are	be	VBP
cord-339752-o6atz33c	155	15	related	relate	VBN
cord-339752-o6atz33c	155	16	to	to	IN
cord-339752-o6atz33c	155	17	higher	high	JJR
cord-339752-o6atz33c	155	18	risk	risk	NN
cord-339752-o6atz33c	155	19	of	of	IN
cord-339752-o6atz33c	155	20	mortality	mortality	NN
cord-339752-o6atz33c	155	21	[	[	-LRB-
cord-339752-o6atz33c	155	22	19	19	CD
cord-339752-o6atz33c	155	23	]	]	-RRB-
cord-339752-o6atz33c	155	24	.	.	.
cord-339752-o6atz33c	156	1	Thus	thus	RB
cord-339752-o6atz33c	156	2	,	,	,
cord-339752-o6atz33c	156	3	nafamostat	nafamostat	NNP
cord-339752-o6atz33c	156	4	mesylate	mesylate	NNP
cord-339752-o6atz33c	156	5	not	not	RB
cord-339752-o6atz33c	156	6	only	only	RB
cord-339752-o6atz33c	156	7	can	can	MD
cord-339752-o6atz33c	156	8	block	block	VB
cord-339752-o6atz33c	156	9	the	the	DT
cord-339752-o6atz33c	156	10	viral	viral	JJ
cord-339752-o6atz33c	156	11	entry	entry	NN
cord-339752-o6atz33c	156	12	,	,	,
cord-339752-o6atz33c	156	13	but	but	CC
cord-339752-o6atz33c	156	14	also	also	RB
cord-339752-o6atz33c	156	15	prevent	prevent	VBP
cord-339752-o6atz33c	156	16	thrombosis	thrombosis	NN
cord-339752-o6atz33c	156	17	and	and	CC
cord-339752-o6atz33c	156	18	disseminated	disseminate	VBN
cord-339752-o6atz33c	156	19	intravascular	intravascular	JJ
cord-339752-o6atz33c	156	20	coagulation	coagulation	NN
cord-339752-o6atz33c	156	21	(	(	-LRB-
cord-339752-o6atz33c	156	22	DIC	DIC	NNP
cord-339752-o6atz33c	156	23	)	)	-RRB-
cord-339752-o6atz33c	156	24	in	in	IN
cord-339752-o6atz33c	156	25	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	156	26	patients	patient	NNS
cord-339752-o6atz33c	156	27	.	.	.
cord-339752-o6atz33c	157	1	A	a	DT
cord-339752-o6atz33c	157	2	clinical	clinical	JJ
cord-339752-o6atz33c	157	3	trial	trial	NN
cord-339752-o6atz33c	157	4	of	of	IN
cord-339752-o6atz33c	157	5	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	157	6	with	with	IN
cord-339752-o6atz33c	157	7	nafamostat	nafamostat	NNP
cord-339752-o6atz33c	157	8	mesylate	mesylate	NNP
cord-339752-o6atz33c	157	9	treatment	treatment	NN
cord-339752-o6atz33c	157	10	in	in	IN
cord-339752-o6atz33c	157	11	Japan	Japan	NNP
cord-339752-o6atz33c	157	12	started	start	VBD
cord-339752-o6atz33c	157	13	in	in	IN
cord-339752-o6atz33c	157	14	March	March	NNP
cord-339752-o6atz33c	157	15	2020	2020	CD
cord-339752-o6atz33c	157	16	.	.	.
cord-339752-o6atz33c	158	1	Because	because	IN
cord-339752-o6atz33c	158	2	SARS	SARS	NNP
cord-339752-o6atz33c	158	3	-	-	HYPH
cord-339752-o6atz33c	158	4	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	158	5	exploits	exploit	VBZ
cord-339752-o6atz33c	158	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	158	7	for	for	IN
cord-339752-o6atz33c	158	8	entry	entry	NN
cord-339752-o6atz33c	158	9	,	,	,
cord-339752-o6atz33c	158	10	some	some	DT
cord-339752-o6atz33c	158	11	scientists	scientist	NNS
cord-339752-o6atz33c	158	12	are	be	VBP
cord-339752-o6atz33c	158	13	concerned	concerned	JJ
cord-339752-o6atz33c	158	14	that	that	IN
cord-339752-o6atz33c	158	15	the	the	DT
cord-339752-o6atz33c	158	16	expression	expression	NN
cord-339752-o6atz33c	158	17	of	of	IN
cord-339752-o6atz33c	158	18	ACE2	ACE2	NNP
cord-339752-o6atz33c	158	19	might	may	MD
cord-339752-o6atz33c	158	20	provide	provide	VB
cord-339752-o6atz33c	158	21	possible	possible	JJ
cord-339752-o6atz33c	158	22	advantageous	advantageous	JJ
cord-339752-o6atz33c	158	23	routes	route	NNS
cord-339752-o6atz33c	158	24	for	for	IN
cord-339752-o6atz33c	158	25	virus	virus	NN
cord-339752-o6atz33c	158	26	entry	entry	NN
cord-339752-o6atz33c	158	27	.	.	.
cord-339752-o6atz33c	159	1	They	-PRON-	PRP
cord-339752-o6atz33c	159	2	suggest	suggest	VBP
cord-339752-o6atz33c	159	3	that	that	IN
cord-339752-o6atz33c	159	4	patients	patient	NNS
cord-339752-o6atz33c	159	5	with	with	IN
cord-339752-o6atz33c	159	6	hypertension	hypertension	NN
cord-339752-o6atz33c	159	7	,	,	,
cord-339752-o6atz33c	159	8	diabetes	diabetes	NN
cord-339752-o6atz33c	159	9	,	,	,
cord-339752-o6atz33c	159	10	and	and	CC
cord-339752-o6atz33c	159	11	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	159	12	diseases	disease	NNS
cord-339752-o6atz33c	159	13	should	should	MD
cord-339752-o6atz33c	159	14	reduce	reduce	VB
cord-339752-o6atz33c	159	15	the	the	DT
cord-339752-o6atz33c	159	16	use	use	NN
cord-339752-o6atz33c	159	17	of	of	IN
cord-339752-o6atz33c	159	18	ACE	ace	NN
cord-339752-o6atz33c	159	19	inhibitors	inhibitor	NNS
cord-339752-o6atz33c	159	20	and	and	CC
cord-339752-o6atz33c	159	21	Ang	Ang	NNP
cord-339752-o6atz33c	159	22	II	II	NNP
cord-339752-o6atz33c	159	23	-	-	HYPH
cord-339752-o6atz33c	159	24	AT1	AT1	NNP
cord-339752-o6atz33c	159	25	blockers	blocker	NNS
cord-339752-o6atz33c	159	26	because	because	IN
cord-339752-o6atz33c	159	27	these	these	DT
cord-339752-o6atz33c	159	28	medicines	medicine	NNS
cord-339752-o6atz33c	159	29	can	can	MD
cord-339752-o6atz33c	159	30	increase	increase	VB
cord-339752-o6atz33c	159	31	the	the	DT
cord-339752-o6atz33c	159	32	expression	expression	NN
cord-339752-o6atz33c	159	33	of	of	IN
cord-339752-o6atz33c	159	34	ACE2	ACE2	NNP
cord-339752-o6atz33c	159	35	[	[	-LRB-
cord-339752-o6atz33c	159	36	51	51	CD
cord-339752-o6atz33c	159	37	]	]	-RRB-
cord-339752-o6atz33c	159	38	.	.	.
cord-339752-o6atz33c	160	1	Ibuprofen	ibuprofen	NN
cord-339752-o6atz33c	160	2	and	and	CC
cord-339752-o6atz33c	160	3	thiazolidinediones	thiazolidinedione	NNS
cord-339752-o6atz33c	160	4	were	be	VBD
cord-339752-o6atz33c	160	5	also	also	RB
cord-339752-o6atz33c	160	6	suspected	suspect	VBN
cord-339752-o6atz33c	160	7	of	of	IN
cord-339752-o6atz33c	160	8	increasing	increase	VBG
cord-339752-o6atz33c	160	9	the	the	DT
cord-339752-o6atz33c	160	10	risk	risk	NN
cord-339752-o6atz33c	160	11	of	of	IN
cord-339752-o6atz33c	160	12	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	160	13	for	for	IN
cord-339752-o6atz33c	160	14	the	the	DT
cord-339752-o6atz33c	160	15	same	same	JJ
cord-339752-o6atz33c	160	16	reason	reason	NN
cord-339752-o6atz33c	160	17	[	[	-LRB-
cord-339752-o6atz33c	160	18	52	52	CD
cord-339752-o6atz33c	160	19	]	]	-RRB-
cord-339752-o6atz33c	160	20	.	.	.
cord-339752-o6atz33c	161	1	However	however	RB
cord-339752-o6atz33c	161	2	,	,	,
cord-339752-o6atz33c	161	3	there	there	EX
cord-339752-o6atz33c	161	4	is	be	VBZ
cord-339752-o6atz33c	161	5	no	no	DT
cord-339752-o6atz33c	161	6	evidence	evidence	NN
cord-339752-o6atz33c	161	7	that	that	IN
cord-339752-o6atz33c	161	8	those	those	DT
cord-339752-o6atz33c	161	9	medicines	medicine	NNS
cord-339752-o6atz33c	161	10	can	can	MD
cord-339752-o6atz33c	161	11	facilitate	facilitate	VB
cord-339752-o6atz33c	161	12	SARS	SARS	NNP
cord-339752-o6atz33c	161	13	-	-	HYPH
cord-339752-o6atz33c	161	14	CoV	CoV	NNP
cord-339752-o6atz33c	161	15	or	or	CC
cord-339752-o6atz33c	161	16	SARS	SARS	NNP
cord-339752-o6atz33c	161	17	-	-	HYPH
cord-339752-o6atz33c	161	18	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	161	19	infection	infection	NN
cord-339752-o6atz33c	161	20	.	.	.
cord-339752-o6atz33c	162	1	On	on	IN
cord-339752-o6atz33c	162	2	the	the	DT
cord-339752-o6atz33c	162	3	contrary	contrary	NN
cord-339752-o6atz33c	162	4	,	,	,
cord-339752-o6atz33c	162	5	SARS	SARS	NNP
cord-339752-o6atz33c	162	6	-	-	HYPH
cord-339752-o6atz33c	162	7	CoV	CoV	NNP
cord-339752-o6atz33c	162	8	infection	infection	NN
cord-339752-o6atz33c	162	9	could	could	MD
cord-339752-o6atz33c	162	10	reduce	reduce	VB
cord-339752-o6atz33c	162	11	ACE2	ACE2	NNP
cord-339752-o6atz33c	162	12	expression	expression	NN
cord-339752-o6atz33c	162	13	and	and	CC
cord-339752-o6atz33c	162	14	worsen	worsen	VB
cord-339752-o6atz33c	162	15	acute	acute	JJ
cord-339752-o6atz33c	162	16	lung	lung	NN
cord-339752-o6atz33c	162	17	failure	failure	NN
cord-339752-o6atz33c	162	18	,	,	,
cord-339752-o6atz33c	162	19	which	which	WDT
cord-339752-o6atz33c	162	20	could	could	MD
cord-339752-o6atz33c	162	21	be	be	VB
cord-339752-o6atz33c	162	22	attenuated	attenuate	VBN
cord-339752-o6atz33c	162	23	by	by	IN
cord-339752-o6atz33c	162	24	blocking	block	VBG
cord-339752-o6atz33c	162	25	the	the	DT
cord-339752-o6atz33c	162	26	RAAS	RAAS	NNP
cord-339752-o6atz33c	162	27	pathway	pathway	NN
cord-339752-o6atz33c	162	28	[	[	-LRB-
cord-339752-o6atz33c	162	29	53	53	CD
cord-339752-o6atz33c	162	30	]	]	-RRB-
cord-339752-o6atz33c	162	31	.	.	.
cord-339752-o6atz33c	163	1	ACE2	ace2	JJ
cord-339752-o6atz33c	163	2	expression	expression	NN
cord-339752-o6atz33c	163	3	was	be	VBD
cord-339752-o6atz33c	163	4	also	also	RB
cord-339752-o6atz33c	163	5	shown	show	VBN
cord-339752-o6atz33c	163	6	to	to	TO
cord-339752-o6atz33c	163	7	protect	protect	VB
cord-339752-o6atz33c	163	8	against	against	IN
cord-339752-o6atz33c	163	9	severe	severe	JJ
cord-339752-o6atz33c	163	10	acute	acute	JJ
cord-339752-o6atz33c	163	11	lung	lung	NN
cord-339752-o6atz33c	163	12	failure	failure	NN
cord-339752-o6atz33c	163	13	in	in	IN
cord-339752-o6atz33c	163	14	a	a	DT
cord-339752-o6atz33c	163	15	mouse	mouse	NN
cord-339752-o6atz33c	163	16	model	model	NN
cord-339752-o6atz33c	163	17	[	[	-LRB-
cord-339752-o6atz33c	163	18	54	54	CD
cord-339752-o6atz33c	163	19	]	]	-RRB-
cord-339752-o6atz33c	163	20	.	.	.
cord-339752-o6atz33c	164	1	In	in	IN
cord-339752-o6atz33c	164	2	addition	addition	NN
cord-339752-o6atz33c	164	3	,	,	,
cord-339752-o6atz33c	164	4	cell	cell	NN
cord-339752-o6atz33c	164	5	tropism	tropism	NN
cord-339752-o6atz33c	164	6	of	of	IN
cord-339752-o6atz33c	164	7	SARS	SARS	NNP
cord-339752-o6atz33c	164	8	-	-	HYPH
cord-339752-o6atz33c	164	9	CoV12	CoV12	NNP
cord-339752-o6atz33c	164	10	and	and	CC
cord-339752-o6atz33c	164	11	SARS	SARS	NNP
cord-339752-o6atz33c	164	12	-	-	HYPH
cord-339752-o6atz33c	164	13	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	164	14	did	do	VBD
cord-339752-o6atz33c	164	15	not	not	RB
cord-339752-o6atz33c	164	16	firmly	firmly	RB
cord-339752-o6atz33c	164	17	associate	associate	VB
cord-339752-o6atz33c	164	18	with	with	IN
cord-339752-o6atz33c	164	19	ACE2	ACE2	NNP
cord-339752-o6atz33c	164	20	expression	expression	NN
cord-339752-o6atz33c	164	21	.	.	.
cord-339752-o6atz33c	165	1	ACE2	ACE2	NNP
cord-339752-o6atz33c	165	2	is	be	VBZ
cord-339752-o6atz33c	165	3	expressed	express	VBN
cord-339752-o6atz33c	165	4	on	on	IN
cord-339752-o6atz33c	165	5	both	both	DT
cord-339752-o6atz33c	165	6	type	type	NN
cord-339752-o6atz33c	165	7	I	-PRON-	PRP
cord-339752-o6atz33c	165	8	and	and	CC
cord-339752-o6atz33c	165	9	type	type	NN
cord-339752-o6atz33c	165	10	II	ii	CD
cord-339752-o6atz33c	165	11	pneumocytes	pneumocyte	NNS
cord-339752-o6atz33c	165	12	,	,	,
cord-339752-o6atz33c	165	13	whereas	whereas	IN
cord-339752-o6atz33c	165	14	SARS	SARS	NNP
cord-339752-o6atz33c	165	15	-	-	HYPH
cord-339752-o6atz33c	165	16	CoV	CoV	NNP
cord-339752-o6atz33c	165	17	and	and	CC
cord-339752-o6atz33c	165	18	SARS	SARS	NNP
cord-339752-o6atz33c	165	19	-	-	HYPH
cord-339752-o6atz33c	165	20	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	165	21	only	only	RB
cord-339752-o6atz33c	165	22	make	make	VBP
cord-339752-o6atz33c	165	23	use	use	NN
cord-339752-o6atz33c	165	24	of	of	IN
cord-339752-o6atz33c	165	25	type	type	NN
cord-339752-o6atz33c	165	26	II	ii	NN
cord-339752-o6atz33c	165	27	pneumocytes	pneumocyte	NNS
cord-339752-o6atz33c	165	28	because	because	IN
cord-339752-o6atz33c	165	29	the	the	DT
cord-339752-o6atz33c	165	30	infection	infection	NN
cord-339752-o6atz33c	165	31	requires	require	VBZ
cord-339752-o6atz33c	165	32	co	co	NN
cord-339752-o6atz33c	165	33	-	-	NN
cord-339752-o6atz33c	165	34	expression	expression	NN
cord-339752-o6atz33c	165	35	of	of	IN
cord-339752-o6atz33c	165	36	ACE2	ACE2	NNP
cord-339752-o6atz33c	165	37	and	and	CC
cord-339752-o6atz33c	165	38	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	165	39	as	as	IN
cord-339752-o6atz33c	165	40	we	-PRON-	PRP
cord-339752-o6atz33c	165	41	described	describe	VBD
cord-339752-o6atz33c	165	42	before	before	IN
cord-339752-o6atz33c	165	43	[	[	-LRB-
cord-339752-o6atz33c	165	44	20	20	CD
cord-339752-o6atz33c	165	45	,	,	,
cord-339752-o6atz33c	165	46	55	55	CD
cord-339752-o6atz33c	165	47	,	,	,
cord-339752-o6atz33c	165	48	56	56	CD
cord-339752-o6atz33c	165	49	]	]	-RRB-
cord-339752-o6atz33c	165	50	.	.	.
cord-339752-o6atz33c	166	1	Therefore	therefore	RB
cord-339752-o6atz33c	166	2	,	,	,
cord-339752-o6atz33c	166	3	increasing	increase	VBG
cord-339752-o6atz33c	166	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	166	5	(	(	-LRB-
cord-339752-o6atz33c	166	6	especially	especially	RB
cord-339752-o6atz33c	166	7	circulating	circulate	VBG
cord-339752-o6atz33c	166	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	166	9	)	)	-RRB-
cord-339752-o6atz33c	166	10	or	or	CC
cord-339752-o6atz33c	166	11	Ang-(1	Ang-(1	NNP
cord-339752-o6atz33c	166	12	-	-	HYPH
cord-339752-o6atz33c	166	13	7	7	NNP
cord-339752-o6atz33c	166	14	)	)	-RRB-
cord-339752-o6atz33c	166	15	is	be	VBZ
cord-339752-o6atz33c	166	16	a	a	DT
cord-339752-o6atz33c	166	17	potential	potential	JJ
cord-339752-o6atz33c	166	18	approach	approach	NN
cord-339752-o6atz33c	166	19	to	to	TO
cord-339752-o6atz33c	166	20	reduce	reduce	VB
cord-339752-o6atz33c	166	21	SARS	SARS	NNP
cord-339752-o6atz33c	166	22	-	-	HYPH
cord-339752-o6atz33c	166	23	CoV-2-induced	cov-2-induce	VBN
cord-339752-o6atz33c	166	24	severe	severe	JJ
cord-339752-o6atz33c	166	25	damage	damage	NN
cord-339752-o6atz33c	166	26	and	and	CC
cord-339752-o6atz33c	166	27	to	to	TO
cord-339752-o6atz33c	166	28	protect	protect	VB
cord-339752-o6atz33c	166	29	organs	organ	NNS
cord-339752-o6atz33c	166	30	.	.	.
cord-339752-o6atz33c	167	1	Recently	recently	RB
cord-339752-o6atz33c	167	2	,	,	,
cord-339752-o6atz33c	167	3	an	an	DT
cord-339752-o6atz33c	167	4	international	international	JJ
cord-339752-o6atz33c	167	5	research	research	NN
cord-339752-o6atz33c	167	6	team	team	NN
cord-339752-o6atz33c	167	7	showed	show	VBD
cord-339752-o6atz33c	167	8	that	that	IN
cord-339752-o6atz33c	167	9	clinical	clinical	JJ
cord-339752-o6atz33c	167	10	-	-	HYPH
cord-339752-o6atz33c	167	11	grade	grade	NN
cord-339752-o6atz33c	167	12	human	human	NN
cord-339752-o6atz33c	167	13	soluble	soluble	JJ
cord-339752-o6atz33c	167	14	ACE2	ACE2	NNP
cord-339752-o6atz33c	167	15	could	could	MD
cord-339752-o6atz33c	167	16	combine	combine	VB
cord-339752-o6atz33c	167	17	with	with	IN
cord-339752-o6atz33c	167	18	SARS	SARS	NNP
cord-339752-o6atz33c	167	19	-	-	HYPH
cord-339752-o6atz33c	167	20	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	167	21	and	and	CC
cord-339752-o6atz33c	167	22	decrease	decrease	VB
cord-339752-o6atz33c	167	23	its	-PRON-	PRP$
cord-339752-o6atz33c	167	24	infection	infection	NN
cord-339752-o6atz33c	167	25	rate	rate	NN
cord-339752-o6atz33c	167	26	to	to	IN
cord-339752-o6atz33c	167	27	10005000-times	10005000-times	CD
cord-339752-o6atz33c	167	28	in	in	IN
cord-339752-o6atz33c	167	29	engineered	engineer	VBN
cord-339752-o6atz33c	167	30	human	human	JJ
cord-339752-o6atz33c	167	31	blood	blood	NN
cord-339752-o6atz33c	167	32	vessel	vessel	NN
cord-339752-o6atz33c	167	33	organoids	organoid	NNS
cord-339752-o6atz33c	167	34	and	and	CC
cord-339752-o6atz33c	167	35	human	human	JJ
cord-339752-o6atz33c	167	36	kidney	kidney	NN
cord-339752-o6atz33c	167	37	organoids	organoid	NNS
cord-339752-o6atz33c	167	38	[	[	-LRB-
cord-339752-o6atz33c	167	39	57	57	CD
cord-339752-o6atz33c	167	40	]	]	-RRB-
cord-339752-o6atz33c	167	41	.	.	.
cord-339752-o6atz33c	168	1	Evidence	evidence	NN
cord-339752-o6atz33c	168	2	showed	show	VBD
cord-339752-o6atz33c	168	3	that	that	IN
cord-339752-o6atz33c	168	4	administration	administration	NN
cord-339752-o6atz33c	168	5	with	with	IN
cord-339752-o6atz33c	168	6	Trp	Trp	NNP
cord-339752-o6atz33c	168	7	or	or	CC
cord-339752-o6atz33c	168	8	nicotinamide	nicotinamide	NN
cord-339752-o6atz33c	168	9	could	could	MD
cord-339752-o6atz33c	168	10	reverse	reverse	VB
cord-339752-o6atz33c	168	11	severe	severe	JJ
cord-339752-o6atz33c	168	12	intestinal	intestinal	JJ
cord-339752-o6atz33c	168	13	inflammation	inflammation	NN
cord-339752-o6atz33c	168	14	in	in	IN
cord-339752-o6atz33c	168	15	ACE2	ACE2	NNP
cord-339752-o6atz33c	168	16	knockout	knockout	NN
cord-339752-o6atz33c	168	17	mice	mouse	NNS
cord-339752-o6atz33c	168	18	[	[	-LRB-
cord-339752-o6atz33c	168	19	39	39	CD
cord-339752-o6atz33c	168	20	]	]	-RRB-
cord-339752-o6atz33c	168	21	.	.	.
cord-339752-o6atz33c	169	1	As	as	IN
cord-339752-o6atz33c	169	2	a	a	DT
cord-339752-o6atz33c	169	3	nutrient	nutrient	NN
cord-339752-o6atz33c	169	4	enhancer	enhancer	NN
cord-339752-o6atz33c	169	5	,	,	,
cord-339752-o6atz33c	169	6	Trp	trp	NN
cord-339752-o6atz33c	169	7	and	and	CC
cord-339752-o6atz33c	169	8	its	-PRON-	PRP$
cord-339752-o6atz33c	169	9	metabolites	metabolite	NNS
cord-339752-o6atz33c	169	10	play	play	VBP
cord-339752-o6atz33c	169	11	crucial	crucial	JJ
cord-339752-o6atz33c	169	12	roles	role	NNS
cord-339752-o6atz33c	169	13	in	in	IN
cord-339752-o6atz33c	169	14	gut	gut	NN
cord-339752-o6atz33c	169	15	microbiota	microbiota	NN
cord-339752-o6atz33c	169	16	maintenance	maintenance	NN
cord-339752-o6atz33c	169	17	,	,	,
cord-339752-o6atz33c	169	18	microbial	microbial	JJ
cord-339752-o6atz33c	169	19	metabolism	metabolism	NN
cord-339752-o6atz33c	169	20	,	,	,
cord-339752-o6atz33c	169	21	the	the	DT
cord-339752-o6atz33c	169	22	host	host	NN
cord-339752-o6atz33c	169	23	's	's	POS
cord-339752-o6atz33c	169	24	immune	immune	JJ
cord-339752-o6atz33c	169	25	system	system	NN
cord-339752-o6atz33c	169	26	,	,	,
cord-339752-o6atz33c	169	27	the	the	DT
cord-339752-o6atz33c	169	28	host	host	NN
cord-339752-o6atz33c	169	29	-	-	HYPH
cord-339752-o6atz33c	169	30	microbiome	microbiome	NN
cord-339752-o6atz33c	169	31	interface	interface	NN
cord-339752-o6atz33c	169	32	,	,	,
cord-339752-o6atz33c	169	33	and	and	CC
cord-339752-o6atz33c	169	34	host	host	NN
cord-339752-o6atz33c	169	35	immune	immune	JJ
cord-339752-o6atz33c	169	36	system	system	NN
cord-339752-o6atz33c	169	37	-	-	HYPH
cord-339752-o6atz33c	169	38	intestinal	intestinal	JJ
cord-339752-o6atz33c	169	39	microbiota	microbiota	NN
cord-339752-o6atz33c	169	40	interactions	interaction	NNS
cord-339752-o6atz33c	169	41	.	.	.
cord-339752-o6atz33c	170	1	[	[	-LRB-
cord-339752-o6atz33c	170	2	58	58	CD
cord-339752-o6atz33c	170	3	]	]	-RRB-
cord-339752-o6atz33c	170	4	.	.	.
cord-339752-o6atz33c	171	1	Thus	thus	RB
cord-339752-o6atz33c	171	2	,	,	,
cord-339752-o6atz33c	171	3	supplementation	supplementation	NN
cord-339752-o6atz33c	171	4	with	with	IN
cord-339752-o6atz33c	171	5	Trp	trp	NN
cord-339752-o6atz33c	171	6	or	or	CC
cord-339752-o6atz33c	171	7	nicotinamide	nicotinamide	NN
cord-339752-o6atz33c	171	8	may	may	MD
cord-339752-o6atz33c	171	9	regulate	regulate	VB
cord-339752-o6atz33c	171	10	the	the	DT
cord-339752-o6atz33c	171	11	gut	gut	NN
cord-339752-o6atz33c	171	12	microbiome	microbiome	NN
cord-339752-o6atz33c	171	13	and	and	CC
cord-339752-o6atz33c	171	14	increase	increase	VB
cord-339752-o6atz33c	171	15	antimicrobial	antimicrobial	JJ
cord-339752-o6atz33c	171	16	peptides	peptide	NNS
cord-339752-o6atz33c	171	17	to	to	TO
cord-339752-o6atz33c	171	18	convert	convert	VB
cord-339752-o6atz33c	171	19	SARS	SARS	NNP
cord-339752-o6atz33c	171	20	-	-	HYPH
cord-339752-o6atz33c	171	21	CoV-2-induced	cov-2-induce	VBN
cord-339752-o6atz33c	171	22	lesions	lesion	NNS
cord-339752-o6atz33c	171	23	in	in	IN
cord-339752-o6atz33c	171	24	the	the	DT
cord-339752-o6atz33c	171	25	intestine	intestine	NN
cord-339752-o6atz33c	171	26	and	and	CC
cord-339752-o6atz33c	171	27	further	further	RB
cord-339752-o6atz33c	171	28	improve	improve	VB
cord-339752-o6atz33c	171	29	systemic	systemic	JJ
cord-339752-o6atz33c	171	30	conditions	condition	NNS
cord-339752-o6atz33c	171	31	.	.	.
cord-339752-o6atz33c	172	1	In	in	IN
cord-339752-o6atz33c	172	2	summary	summary	NN
cord-339752-o6atz33c	172	3	,	,	,
cord-339752-o6atz33c	172	4	ACE2	ACE2	NNP
cord-339752-o6atz33c	172	5	plays	play	VBZ
cord-339752-o6atz33c	172	6	essential	essential	JJ
cord-339752-o6atz33c	172	7	roles	role	NNS
cord-339752-o6atz33c	172	8	in	in	IN
cord-339752-o6atz33c	172	9	SARS	SARS	NNP
cord-339752-o6atz33c	172	10	-	-	HYPH
cord-339752-o6atz33c	172	11	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	172	12	cell	cell	NN
cord-339752-o6atz33c	172	13	entry	entry	NN
cord-339752-o6atz33c	172	14	and	and	CC
cord-339752-o6atz33c	172	15	makes	make	VBZ
cord-339752-o6atz33c	172	16	an	an	DT
cord-339752-o6atz33c	172	17	impact	impact	NN
cord-339752-o6atz33c	172	18	on	on	IN
cord-339752-o6atz33c	172	19	the	the	DT
cord-339752-o6atz33c	172	20	progress	progress	NN
cord-339752-o6atz33c	172	21	and	and	CC
cord-339752-o6atz33c	172	22	prognosis	prognosis	NN
cord-339752-o6atz33c	172	23	of	of	IN
cord-339752-o6atz33c	172	24	severe	severe	JJ
cord-339752-o6atz33c	172	25	and	and	CC
cord-339752-o6atz33c	172	26	critical	critical	JJ
cord-339752-o6atz33c	172	27	conditions	condition	NNS
cord-339752-o6atz33c	172	28	of	of	IN
cord-339752-o6atz33c	172	29	COVID-19	covid-19	NN
cord-339752-o6atz33c	172	30	.	.	.
cord-339752-o6atz33c	173	1	Regulating	regulate	VBG
cord-339752-o6atz33c	173	2	ACE2-related	ace2-related	JJ
cord-339752-o6atz33c	173	3	enzymes	enzyme	NNS
cord-339752-o6atz33c	173	4	and	and	CC
cord-339752-o6atz33c	173	5	amino	amino	NN
cord-339752-o6atz33c	173	6	acid	acid	NN
cord-339752-o6atz33c	173	7	intake	intake	NN
cord-339752-o6atz33c	173	8	would	would	MD
cord-339752-o6atz33c	173	9	be	be	VB
cord-339752-o6atz33c	173	10	desirable	desirable	JJ
cord-339752-o6atz33c	173	11	for	for	IN
cord-339752-o6atz33c	173	12	disease	disease	NN
cord-339752-o6atz33c	173	13	control	control	NN
cord-339752-o6atz33c	173	14	.	.	.
cord-339752-o6atz33c	174	1	However	however	RB
cord-339752-o6atz33c	174	2	,	,	,
cord-339752-o6atz33c	174	3	more	more	RBR
cord-339752-o6atz33c	174	4	experimental	experimental	JJ
cord-339752-o6atz33c	174	5	and	and	CC
cord-339752-o6atz33c	174	6	clinical	clinical	JJ
cord-339752-o6atz33c	174	7	studies	study	NNS
cord-339752-o6atz33c	174	8	are	be	VBP
cord-339752-o6atz33c	174	9	required	require	VBN
cord-339752-o6atz33c	174	10	.	.	.
cord-339752-o6atz33c	175	1	Moreover	moreover	RB
cord-339752-o6atz33c	175	2	,	,	,
cord-339752-o6atz33c	175	3	pathogenesis	pathogenesis	NN
cord-339752-o6atz33c	175	4	of	of	IN
cord-339752-o6atz33c	175	5	severe	severe	JJ
cord-339752-o6atz33c	175	6	and	and	CC
cord-339752-o6atz33c	175	7	critical	critical	JJ
cord-339752-o6atz33c	175	8	conditions	condition	NNS
cord-339752-o6atz33c	175	9	of	of	IN
cord-339752-o6atz33c	175	10	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	175	11	is	be	VBZ
cord-339752-o6atz33c	175	12	very	very	RB
cord-339752-o6atz33c	175	13	complicated	complicated	JJ
cord-339752-o6atz33c	175	14	.	.	.
cord-339752-o6atz33c	176	1	Other	other	JJ
cord-339752-o6atz33c	176	2	molecules	molecule	NNS
cord-339752-o6atz33c	176	3	,	,	,
cord-339752-o6atz33c	176	4	such	such	JJ
cord-339752-o6atz33c	176	5	as	as	IN
cord-339752-o6atz33c	176	6	IL-6	IL-6	NNP
cord-339752-o6atz33c	176	7	,	,	,
cord-339752-o6atz33c	176	8	also	also	RB
cord-339752-o6atz33c	176	9	play	play	VB
cord-339752-o6atz33c	176	10	important	important	JJ
cord-339752-o6atz33c	176	11	roles	role	NNS
cord-339752-o6atz33c	176	12	in	in	IN
cord-339752-o6atz33c	176	13	the	the	DT
cord-339752-o6atz33c	176	14	disease	disease	NN
cord-339752-o6atz33c	176	15	.	.	.
cord-339752-o6atz33c	177	1	Therefore	therefore	RB
cord-339752-o6atz33c	177	2	,	,	,
cord-339752-o6atz33c	177	3	therapeutic	therapeutic	JJ
cord-339752-o6atz33c	177	4	strategies	strategy	NNS
cord-339752-o6atz33c	177	5	should	should	MD
cord-339752-o6atz33c	177	6	be	be	VB
cord-339752-o6atz33c	177	7	flexibly	flexibly	RB
cord-339752-o6atz33c	177	8	changed	change	VBN
cord-339752-o6atz33c	177	9	according	accord	VBG
cord-339752-o6atz33c	177	10	to	to	IN
cord-339752-o6atz33c	177	11	the	the	DT
cord-339752-o6atz33c	177	12	patient	patient	NN
cord-339752-o6atz33c	177	13	's	's	POS
cord-339752-o6atz33c	177	14	clinical	clinical	JJ
cord-339752-o6atz33c	177	15	inspection	inspection	NN
cord-339752-o6atz33c	177	16	results	result	NNS
cord-339752-o6atz33c	177	17	.	.	.
cord-339752-o6atz33c	178	1	Funding	funding	NN
cord-339752-o6atz33c	178	2	:	:	:
cord-339752-o6atz33c	179	1	This	this	DT
cord-339752-o6atz33c	179	2	research	research	NN
cord-339752-o6atz33c	179	3	received	receive	VBD
cord-339752-o6atz33c	179	4	no	no	DT
cord-339752-o6atz33c	179	5	external	external	JJ
cord-339752-o6atz33c	179	6	funding	funding	NN
cord-339752-o6atz33c	179	7	.	.	.
cord-339752-o6atz33c	180	1	Characteristics	characteristic	NNS
cord-339752-o6atz33c	180	2	of	of	IN
cord-339752-o6atz33c	180	3	and	and	CC
cord-339752-o6atz33c	180	4	Important	Important	NNP
cord-339752-o6atz33c	180	5	Lessons	lesson	NNS
cord-339752-o6atz33c	180	6	from	from	IN
cord-339752-o6atz33c	180	7	the	the	DT
cord-339752-o6atz33c	180	8	Coronavirus	Coronavirus	NNP
cord-339752-o6atz33c	180	9	Disease	Disease	NNP
cord-339752-o6atz33c	180	10	2019	2019	CD
cord-339752-o6atz33c	180	11	(	(	-LRB-
cord-339752-o6atz33c	180	12	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	180	13	)	)	-RRB-
cord-339752-o6atz33c	180	14	Outbreak	outbreak	NN
cord-339752-o6atz33c	180	15	in	in	IN
cord-339752-o6atz33c	180	16	China	China	NNP
cord-339752-o6atz33c	180	17	:	:	:
cord-339752-o6atz33c	180	18	Summary	Summary	NNP
cord-339752-o6atz33c	180	19	of	of	IN
cord-339752-o6atz33c	180	20	a	a	DT
cord-339752-o6atz33c	180	21	Report	Report	NNP
cord-339752-o6atz33c	180	22	of	of	IN
cord-339752-o6atz33c	180	23	72	72	CD
cord-339752-o6atz33c	180	24	314	314	CD
cord-339752-o6atz33c	180	25	Cases	case	NNS
cord-339752-o6atz33c	180	26	from	from	IN
cord-339752-o6atz33c	180	27	the	the	DT
cord-339752-o6atz33c	180	28	Chinese	Chinese	NNP
cord-339752-o6atz33c	180	29	Center	Center	NNP
cord-339752-o6atz33c	180	30	for	for	IN
cord-339752-o6atz33c	180	31	Disease	Disease	NNP
cord-339752-o6atz33c	180	32	Control	Control	NNP
cord-339752-o6atz33c	180	33	and	and	CC
cord-339752-o6atz33c	180	34	Prevention	Prevention	NNP
cord-339752-o6atz33c	180	35	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	180	36	-	-	HYPH
cord-339752-o6atz33c	180	37	converting	convert	VBG
cord-339752-o6atz33c	180	38	enzyme	enzyme	NN
cord-339752-o6atz33c	180	39	2	2	CD
cord-339752-o6atz33c	180	40	is	be	VBZ
cord-339752-o6atz33c	180	41	a	a	DT
cord-339752-o6atz33c	180	42	functional	functional	JJ
cord-339752-o6atz33c	180	43	receptor	receptor	NN
cord-339752-o6atz33c	180	44	for	for	IN
cord-339752-o6atz33c	180	45	the	the	DT
cord-339752-o6atz33c	180	46	SARS	SARS	NNP
cord-339752-o6atz33c	180	47	coronavirus	coronavirus	NN
cord-339752-o6atz33c	181	1	SARS	SARS	NNP
cord-339752-o6atz33c	181	2	-	-	HYPH
cord-339752-o6atz33c	181	3	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	181	4	Cell	Cell	NNP
cord-339752-o6atz33c	181	5	Entry	entry	NN
cord-339752-o6atz33c	181	6	Depends	depend	VBZ
cord-339752-o6atz33c	181	7	on	on	IN
cord-339752-o6atz33c	181	8	ACE2	ACE2	NNP
cord-339752-o6atz33c	181	9	and	and	CC
cord-339752-o6atz33c	181	10	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	181	11	and	and	CC
cord-339752-o6atz33c	181	12	Is	be	VBZ
cord-339752-o6atz33c	181	13	Blocked	block	VBN
cord-339752-o6atz33c	181	14	by	by	IN
cord-339752-o6atz33c	181	15	a	a	DT
cord-339752-o6atz33c	181	16	Clinically	clinically	RB
cord-339752-o6atz33c	181	17	Proven	prove	VBN
cord-339752-o6atz33c	181	18	Protease	protease	NN
cord-339752-o6atz33c	181	19	Inhibitor	inhibitor	NN
cord-339752-o6atz33c	181	20	Enhanced	enhance	VBN
cord-339752-o6atz33c	181	21	isolation	isolation	NN
cord-339752-o6atz33c	181	22	of	of	IN
cord-339752-o6atz33c	181	23	SARS	SARS	NNP
cord-339752-o6atz33c	181	24	-	-	HYPH
cord-339752-o6atz33c	181	25	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	181	26	by	by	IN
cord-339752-o6atz33c	181	27	TMPRSS2-expressing	tmprss2-expresse	VBG
cord-339752-o6atz33c	181	28	cells	cell	NNS
cord-339752-o6atz33c	182	1	A	a	DT
cord-339752-o6atz33c	182	2	human	human	JJ
cord-339752-o6atz33c	182	3	homolog	homolog	NN
cord-339752-o6atz33c	182	4	of	of	IN
cord-339752-o6atz33c	182	5	angiotensin	angiotensin	NN
cord-339752-o6atz33c	182	6	-	-	HYPH
cord-339752-o6atz33c	182	7	converting	convert	VBG
cord-339752-o6atz33c	182	8	enzyme	enzyme	NN
cord-339752-o6atz33c	182	9	.	.	.
cord-339752-o6atz33c	183	1	Cloning	clone	VBG
cord-339752-o6atz33c	183	2	and	and	CC
cord-339752-o6atz33c	183	3	functional	functional	JJ
cord-339752-o6atz33c	183	4	expression	expression	NN
cord-339752-o6atz33c	183	5	as	as	IN
cord-339752-o6atz33c	183	6	a	a	DT
cord-339752-o6atz33c	183	7	captopril	captopril	NN
cord-339752-o6atz33c	183	8	-	-	HYPH
cord-339752-o6atz33c	183	9	insensitive	insensitive	JJ
cord-339752-o6atz33c	183	10	carboxypeptidase	carboxypeptidase	NN
cord-339752-o6atz33c	183	11	Tumor	tumor	NN
cord-339752-o6atz33c	183	12	necrosis	necrosis	NN
cord-339752-o6atz33c	183	13	factor	factor	NN
cord-339752-o6atz33c	183	14	-	-	HYPH
cord-339752-o6atz33c	183	15	alpha	alpha	NN
cord-339752-o6atz33c	183	16	convertase	convertase	NN
cord-339752-o6atz33c	183	17	(	(	-LRB-
cord-339752-o6atz33c	183	18	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	183	19	)	)	-RRB-
cord-339752-o6atz33c	183	20	mediates	mediate	VBZ
cord-339752-o6atz33c	183	21	regulated	regulate	VBN
cord-339752-o6atz33c	183	22	ectodomain	ectodomain	NN
cord-339752-o6atz33c	183	23	shedding	shedding	NN
cord-339752-o6atz33c	183	24	of	of	IN
cord-339752-o6atz33c	183	25	the	the	DT
cord-339752-o6atz33c	183	26	severe	severe	JJ
cord-339752-o6atz33c	183	27	-	-	HYPH
cord-339752-o6atz33c	183	28	acute	acute	JJ
cord-339752-o6atz33c	183	29	respiratory	respiratory	JJ
cord-339752-o6atz33c	183	30	syndrome	syndrome	NN
cord-339752-o6atz33c	183	31	-	-	HYPH
cord-339752-o6atz33c	183	32	coronavirus	coronavirus	NN
cord-339752-o6atz33c	183	33	(	(	-LRB-
cord-339752-o6atz33c	183	34	SARS	SARS	NNP
cord-339752-o6atz33c	183	35	-	-	HYPH
cord-339752-o6atz33c	183	36	CoV	CoV	NNP
cord-339752-o6atz33c	183	37	)	)	-RRB-
cord-339752-o6atz33c	183	38	receptor	receptor	NN
cord-339752-o6atz33c	183	39	,	,	,
cord-339752-o6atz33c	183	40	angiotensin	angiotensin	NN
cord-339752-o6atz33c	183	41	-	-	HYPH
cord-339752-o6atz33c	183	42	converting	convert	VBG
cord-339752-o6atz33c	183	43	enzyme-2	enzyme-2	NNP
cord-339752-o6atz33c	183	44	(	(	-LRB-
cord-339752-o6atz33c	183	45	ACE2	ACE2	NNP
cord-339752-o6atz33c	183	46	)	)	-RRB-
cord-339752-o6atz33c	183	47	Receptor	receptor	NN
cord-339752-o6atz33c	183	48	and	and	CC
cord-339752-o6atz33c	183	49	viral	viral	JJ
cord-339752-o6atz33c	183	50	determinants	determinant	NNS
cord-339752-o6atz33c	183	51	of	of	IN
cord-339752-o6atz33c	183	52	SARS	SARS	NNP
cord-339752-o6atz33c	183	53	-	-	HYPH
cord-339752-o6atz33c	183	54	coronavirus	coronavirus	NN
cord-339752-o6atz33c	183	55	adaptation	adaptation	NN
cord-339752-o6atz33c	183	56	to	to	IN
cord-339752-o6atz33c	183	57	human	human	JJ
cord-339752-o6atz33c	183	58	ACE2	ACE2	NNP
cord-339752-o6atz33c	183	59	Tissue	tissue	NN
cord-339752-o6atz33c	183	60	distribution	distribution	NN
cord-339752-o6atz33c	183	61	of	of	IN
cord-339752-o6atz33c	183	62	ACE2	ACE2	NNP
cord-339752-o6atz33c	183	63	protein	protein	NN
cord-339752-o6atz33c	183	64	,	,	,
cord-339752-o6atz33c	183	65	the	the	DT
cord-339752-o6atz33c	183	66	functional	functional	JJ
cord-339752-o6atz33c	183	67	receptor	receptor	NN
cord-339752-o6atz33c	183	68	for	for	IN
cord-339752-o6atz33c	183	69	SARS	SARS	NNP
cord-339752-o6atz33c	183	70	coronavirus	coronavirus	NN
cord-339752-o6atz33c	183	71	.	.	.
cord-339752-o6atz33c	184	1	A	a	DT
cord-339752-o6atz33c	184	2	first	first	JJ
cord-339752-o6atz33c	184	3	step	step	NN
cord-339752-o6atz33c	184	4	in	in	IN
cord-339752-o6atz33c	184	5	understanding	understand	VBG
cord-339752-o6atz33c	184	6	SARS	SARS	NNP
cord-339752-o6atz33c	184	7	pathogenesis	pathogenesis	NN
cord-339752-o6atz33c	184	8	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	184	9	-	-	HYPH
cord-339752-o6atz33c	184	10	converting	convert	VBG
cord-339752-o6atz33c	184	11	enzyme	enzyme	NN
cord-339752-o6atz33c	184	12	2	2	CD
cord-339752-o6atz33c	184	13	is	be	VBZ
cord-339752-o6atz33c	184	14	an	an	DT
cord-339752-o6atz33c	184	15	essential	essential	JJ
cord-339752-o6atz33c	184	16	regulator	regulator	NN
cord-339752-o6atz33c	184	17	of	of	IN
cord-339752-o6atz33c	184	18	heart	heart	NN
cord-339752-o6atz33c	184	19	function	function	NN
cord-339752-o6atz33c	184	20	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	184	21	-	-	HYPH
cord-339752-o6atz33c	184	22	converting	convert	VBG
cord-339752-o6atz33c	184	23	enzyme	enzyme	NN
cord-339752-o6atz33c	184	24	2	2	CD
cord-339752-o6atz33c	184	25	overexpression	overexpression	NN
cord-339752-o6atz33c	184	26	in	in	IN
cord-339752-o6atz33c	184	27	the	the	DT
cord-339752-o6atz33c	184	28	subfornical	subfornical	JJ
cord-339752-o6atz33c	184	29	organ	organ	NN
cord-339752-o6atz33c	184	30	prevents	prevent	VBZ
cord-339752-o6atz33c	184	31	the	the	DT
cord-339752-o6atz33c	184	32	angiotensin	angiotensin	NN
cord-339752-o6atz33c	184	33	II	II	NNP
cord-339752-o6atz33c	184	34	-	-	HYPH
cord-339752-o6atz33c	184	35	mediated	mediate	VBN
cord-339752-o6atz33c	184	36	pressor	pressor	NN
cord-339752-o6atz33c	184	37	and	and	CC
cord-339752-o6atz33c	184	38	drinking	drink	VBG
cord-339752-o6atz33c	184	39	responses	response	NNS
cord-339752-o6atz33c	184	40	and	and	CC
cord-339752-o6atz33c	184	41	is	be	VBZ
cord-339752-o6atz33c	184	42	associated	associate	VBN
cord-339752-o6atz33c	184	43	with	with	IN
cord-339752-o6atz33c	184	44	angiotensin	angiotensin	NN
cord-339752-o6atz33c	184	45	II	II	NNP
cord-339752-o6atz33c	184	46	type	type	NN
cord-339752-o6atz33c	184	47	1	1	CD
cord-339752-o6atz33c	184	48	receptor	receptor	NN
cord-339752-o6atz33c	184	49	downregulation	downregulation	NN
cord-339752-o6atz33c	184	50	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	184	51	and	and	CC
cord-339752-o6atz33c	184	52	ADAM17	ADAM17	NNP
cord-339752-o6atz33c	184	53	cleave	cleave	VB
cord-339752-o6atz33c	184	54	ACE2	ACE2	NNP
cord-339752-o6atz33c	184	55	differentially	differentially	RB
cord-339752-o6atz33c	185	1	and	and	CC
cord-339752-o6atz33c	185	2	only	only	JJ
cord-339752-o6atz33c	185	3	proteolysis	proteolysis	NN
cord-339752-o6atz33c	185	4	by	by	IN
cord-339752-o6atz33c	185	5	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	185	6	augments	augment	VBZ
cord-339752-o6atz33c	185	7	entry	entry	NN
cord-339752-o6atz33c	185	8	driven	drive	VBN
cord-339752-o6atz33c	185	9	by	by	IN
cord-339752-o6atz33c	185	10	the	the	DT
cord-339752-o6atz33c	185	11	severe	severe	JJ
cord-339752-o6atz33c	185	12	acute	acute	JJ
cord-339752-o6atz33c	185	13	respiratory	respiratory	JJ
cord-339752-o6atz33c	185	14	syndrome	syndrome	NN
cord-339752-o6atz33c	185	15	coronavirus	coronavirus	NN
cord-339752-o6atz33c	185	16	spike	spike	NN
cord-339752-o6atz33c	185	17	protein	protein	NN
cord-339752-o6atz33c	185	18	Efficient	efficient	JJ
cord-339752-o6atz33c	185	19	activation	activation	NN
cord-339752-o6atz33c	185	20	of	of	IN
cord-339752-o6atz33c	185	21	the	the	DT
cord-339752-o6atz33c	185	22	severe	severe	JJ
cord-339752-o6atz33c	185	23	acute	acute	JJ
cord-339752-o6atz33c	185	24	respiratory	respiratory	JJ
cord-339752-o6atz33c	185	25	syndrome	syndrome	NN
cord-339752-o6atz33c	185	26	coronavirus	coronavirus	NN
cord-339752-o6atz33c	185	27	spike	spike	NN
cord-339752-o6atz33c	185	28	protein	protein	NN
cord-339752-o6atz33c	185	29	by	by	IN
cord-339752-o6atz33c	185	30	the	the	DT
cord-339752-o6atz33c	185	31	transmembrane	transmembrane	NNP
cord-339752-o6atz33c	185	32	protease	protease	NN
cord-339752-o6atz33c	185	33	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	186	1	A	a	DT
cord-339752-o6atz33c	186	2	transmembrane	transmembrane	NN
cord-339752-o6atz33c	186	3	serine	serine	NN
cord-339752-o6atz33c	186	4	protease	protease	NN
cord-339752-o6atz33c	186	5	is	be	VBZ
cord-339752-o6atz33c	186	6	linked	link	VBN
cord-339752-o6atz33c	186	7	to	to	IN
cord-339752-o6atz33c	186	8	the	the	DT
cord-339752-o6atz33c	186	9	severe	severe	JJ
cord-339752-o6atz33c	186	10	acute	acute	JJ
cord-339752-o6atz33c	186	11	respiratory	respiratory	JJ
cord-339752-o6atz33c	186	12	syndrome	syndrome	NN
cord-339752-o6atz33c	186	13	coronavirus	coronavirus	NN
cord-339752-o6atz33c	186	14	receptor	receptor	NN
cord-339752-o6atz33c	186	15	and	and	CC
cord-339752-o6atz33c	186	16	activates	activate	VBZ
cord-339752-o6atz33c	186	17	virus	virus	NN
cord-339752-o6atz33c	186	18	entry	entry	NN
cord-339752-o6atz33c	186	19	Differential	differential	JJ
cord-339752-o6atz33c	186	20	downregulation	downregulation	NN
cord-339752-o6atz33c	186	21	of	of	IN
cord-339752-o6atz33c	186	22	ACE2	ACE2	NNP
cord-339752-o6atz33c	186	23	by	by	IN
cord-339752-o6atz33c	186	24	the	the	DT
cord-339752-o6atz33c	186	25	spike	spike	NN
cord-339752-o6atz33c	186	26	proteins	protein	NNS
cord-339752-o6atz33c	186	27	of	of	IN
cord-339752-o6atz33c	186	28	severe	severe	JJ
cord-339752-o6atz33c	186	29	acute	acute	JJ
cord-339752-o6atz33c	186	30	respiratory	respiratory	JJ
cord-339752-o6atz33c	186	31	syndrome	syndrome	NN
cord-339752-o6atz33c	186	32	coronavirus	coronavirus	NN
cord-339752-o6atz33c	186	33	and	and	CC
cord-339752-o6atz33c	186	34	human	human	JJ
cord-339752-o6atz33c	186	35	coronavirus	coronavirus	NN
cord-339752-o6atz33c	187	1	NL63	NL63	NNP
cord-339752-o6atz33c	187	2	Protease	Protease	NNP
cord-339752-o6atz33c	187	3	-	-	HYPH
cord-339752-o6atz33c	187	4	mediated	mediate	VBN
cord-339752-o6atz33c	187	5	enhancement	enhancement	NN
cord-339752-o6atz33c	187	6	of	of	IN
cord-339752-o6atz33c	187	7	severe	severe	JJ
cord-339752-o6atz33c	187	8	acute	acute	JJ
cord-339752-o6atz33c	187	9	respiratory	respiratory	JJ
cord-339752-o6atz33c	187	10	syndrome	syndrome	NN
cord-339752-o6atz33c	187	11	coronavirus	coronavirus	NN
cord-339752-o6atz33c	187	12	infection	infection	NN
cord-339752-o6atz33c	187	13	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	187	14	Contributes	contribute	VBZ
cord-339752-o6atz33c	187	15	to	to	IN
cord-339752-o6atz33c	187	16	Virus	Virus	NNP
cord-339752-o6atz33c	187	17	Spread	Spread	NNP
cord-339752-o6atz33c	187	18	and	and	CC
cord-339752-o6atz33c	187	19	Immunopathology	immunopathology	NN
cord-339752-o6atz33c	187	20	in	in	IN
cord-339752-o6atz33c	187	21	the	the	DT
cord-339752-o6atz33c	187	22	Airways	Airways	NNPS
cord-339752-o6atz33c	187	23	of	of	IN
cord-339752-o6atz33c	187	24	Murine	Murine	NNP
cord-339752-o6atz33c	187	25	Models	Models	NNPS
cord-339752-o6atz33c	187	26	after	after	IN
cord-339752-o6atz33c	187	27	Coronavirus	Coronavirus	NNP
cord-339752-o6atz33c	187	28	Infection	Infection	NNP
cord-339752-o6atz33c	187	29	Cloning	cloning	NN
cord-339752-o6atz33c	187	30	and	and	CC
cord-339752-o6atz33c	187	31	characterization	characterization	NN
cord-339752-o6atz33c	187	32	of	of	IN
cord-339752-o6atz33c	187	33	the	the	DT
cord-339752-o6atz33c	187	34	cDNA	cdna	NN
cord-339752-o6atz33c	187	35	and	and	CC
cord-339752-o6atz33c	187	36	gene	gene	NN
cord-339752-o6atz33c	187	37	for	for	IN
cord-339752-o6atz33c	187	38	human	human	JJ
cord-339752-o6atz33c	187	39	epitheliasin	epitheliasin	NNP
cord-339752-o6atz33c	187	40	Prostate	Prostate	NNP
cord-339752-o6atz33c	187	41	-	-	HYPH
cord-339752-o6atz33c	187	42	localized	localize	VBN
cord-339752-o6atz33c	187	43	and	and	CC
cord-339752-o6atz33c	187	44	androgen	androgen	NN
cord-339752-o6atz33c	187	45	-	-	HYPH
cord-339752-o6atz33c	187	46	regulated	regulate	VBN
cord-339752-o6atz33c	187	47	expression	expression	NN
cord-339752-o6atz33c	187	48	of	of	IN
cord-339752-o6atz33c	187	49	the	the	DT
cord-339752-o6atz33c	187	50	membrane	membrane	NN
cord-339752-o6atz33c	187	51	-	-	HYPH
cord-339752-o6atz33c	187	52	bound	bind	VBN
cord-339752-o6atz33c	187	53	serine	serine	NN
cord-339752-o6atz33c	187	54	protease	protease	NN
cord-339752-o6atz33c	188	1	TMPRSS2	TMPRSS2	NNP
cord-339752-o6atz33c	188	2	SARS	SARS	NNP
cord-339752-o6atz33c	188	3	-	-	HYPH
cord-339752-o6atz33c	188	4	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	188	5	receptor	receptor	NN
cord-339752-o6atz33c	188	6	ACE2	ACE2	NNP
cord-339752-o6atz33c	188	7	is	be	VBZ
cord-339752-o6atz33c	188	8	an	an	DT
cord-339752-o6atz33c	188	9	interferon	interferon	NN
cord-339752-o6atz33c	188	10	-	-	HYPH
cord-339752-o6atz33c	188	11	stimulated	stimulate	VBN
cord-339752-o6atz33c	188	12	gene	gene	NN
cord-339752-o6atz33c	188	13	in	in	IN
cord-339752-o6atz33c	188	14	human	human	JJ
cord-339752-o6atz33c	188	15	airway	airway	NN
cord-339752-o6atz33c	188	16	epithelial	epithelial	JJ
cord-339752-o6atz33c	188	17	cells	cell	NNS
cord-339752-o6atz33c	188	18	and	and	CC
cord-339752-o6atz33c	188	19	is	be	VBZ
cord-339752-o6atz33c	188	20	detected	detect	VBN
cord-339752-o6atz33c	188	21	in	in	IN
cord-339752-o6atz33c	188	22	specific	specific	JJ
cord-339752-o6atz33c	188	23	cell	cell	NN
cord-339752-o6atz33c	188	24	subsets	subset	NNS
cord-339752-o6atz33c	188	25	across	across	IN
cord-339752-o6atz33c	188	26	tissues	tissue	NNS
cord-339752-o6atz33c	188	27	Clinical	clinical	JJ
cord-339752-o6atz33c	188	28	course	course	NN
cord-339752-o6atz33c	188	29	and	and	CC
cord-339752-o6atz33c	188	30	risk	risk	NN
cord-339752-o6atz33c	188	31	factors	factor	NNS
cord-339752-o6atz33c	188	32	for	for	IN
cord-339752-o6atz33c	188	33	mortality	mortality	NN
cord-339752-o6atz33c	188	34	of	of	IN
cord-339752-o6atz33c	188	35	adult	adult	NN
cord-339752-o6atz33c	188	36	inpatients	inpatient	NNS
cord-339752-o6atz33c	188	37	with	with	IN
cord-339752-o6atz33c	188	38	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	188	39	in	in	IN
cord-339752-o6atz33c	188	40	Wuhan	Wuhan	NNP
cord-339752-o6atz33c	188	41	,	,	,
cord-339752-o6atz33c	188	42	China	China	NNP
cord-339752-o6atz33c	188	43	:	:	:
cord-339752-o6atz33c	189	1	A	a	DT
cord-339752-o6atz33c	189	2	retrospective	retrospective	JJ
cord-339752-o6atz33c	189	3	cohort	cohort	NN
cord-339752-o6atz33c	189	4	study	study	NN
cord-339752-o6atz33c	190	1	A	a	DT
cord-339752-o6atz33c	190	2	novel	novel	JJ
cord-339752-o6atz33c	190	3	angiotensin	angiotensin	NN
cord-339752-o6atz33c	190	4	-	-	HYPH
cord-339752-o6atz33c	190	5	converting	convert	VBG
cord-339752-o6atz33c	190	6	enzyme	enzyme	NN
cord-339752-o6atz33c	190	7	-	-	HYPH
cord-339752-o6atz33c	190	8	related	relate	VBN
cord-339752-o6atz33c	190	9	carboxypeptidase	carboxypeptidase	NN
cord-339752-o6atz33c	190	10	(	(	-LRB-
cord-339752-o6atz33c	190	11	ACE2	ACE2	NNP
cord-339752-o6atz33c	190	12	)	)	-RRB-
cord-339752-o6atz33c	190	13	converts	convert	VBZ
cord-339752-o6atz33c	191	1	angiotensin	angiotensin	NN
cord-339752-o6atz33c	191	2	I	-PRON-	PRP
cord-339752-o6atz33c	191	3	to	to	IN
cord-339752-o6atz33c	192	1	angiotensin	angiotensin	NNP
cord-339752-o6atz33c	192	2	1	1	CD
cord-339752-o6atz33c	192	3	-	-	SYM
cord-339752-o6atz33c	192	4	9	9	CD
cord-339752-o6atz33c	192	5	ACEH	ACEH	NNP
cord-339752-o6atz33c	192	6	/	/	SYM
cord-339752-o6atz33c	192	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	192	8	is	be	VBZ
cord-339752-o6atz33c	192	9	a	a	DT
cord-339752-o6atz33c	192	10	novel	novel	JJ
cord-339752-o6atz33c	192	11	mammalian	mammalian	JJ
cord-339752-o6atz33c	192	12	metallocarboxypeptidase	metallocarboxypeptidase	NN
cord-339752-o6atz33c	192	13	and	and	CC
cord-339752-o6atz33c	192	14	a	a	DT
cord-339752-o6atz33c	192	15	homologue	homologue	NN
cord-339752-o6atz33c	192	16	of	of	IN
cord-339752-o6atz33c	192	17	angiotensin	angiotensin	NN
cord-339752-o6atz33c	192	18	-	-	HYPH
cord-339752-o6atz33c	192	19	converting	convert	VBG
cord-339752-o6atz33c	192	20	enzyme	enzyme	NN
cord-339752-o6atz33c	192	21	insensitive	insensitive	JJ
cord-339752-o6atz33c	192	22	to	to	IN
cord-339752-o6atz33c	192	23	ACE	ace	NN
cord-339752-o6atz33c	192	24	inhibitors	inhibitor	NNS
cord-339752-o6atz33c	192	25	.	.	.
cord-339752-o6atz33c	193	1	Can	Can	MD
cord-339752-o6atz33c	193	2	Hydrolysis	hydrolysis	NN
cord-339752-o6atz33c	193	3	of	of	IN
cord-339752-o6atz33c	193	4	biological	biological	JJ
cord-339752-o6atz33c	193	5	peptides	peptide	NNS
cord-339752-o6atz33c	193	6	by	by	IN
cord-339752-o6atz33c	193	7	human	human	JJ
cord-339752-o6atz33c	193	8	angiotensin	angiotensin	NN
cord-339752-o6atz33c	193	9	-	-	HYPH
cord-339752-o6atz33c	193	10	converting	convert	VBG
cord-339752-o6atz33c	193	11	enzyme	enzyme	NN
cord-339752-o6atz33c	193	12	-	-	HYPH
cord-339752-o6atz33c	193	13	related	relate	VBN
cord-339752-o6atz33c	193	14	carboxypeptidase	carboxypeptidase	NN
cord-339752-o6atz33c	193	15	Angiotensin-(1	Angiotensin-(1	NNP
cord-339752-o6atz33c	193	16	-	-	HYPH
cord-339752-o6atz33c	193	17	7	7	CD
cord-339752-o6atz33c	193	18	)	)	-RRB-
cord-339752-o6atz33c	193	19	prevents	prevent	VBZ
cord-339752-o6atz33c	193	20	activation	activation	NN
cord-339752-o6atz33c	193	21	of	of	IN
cord-339752-o6atz33c	193	22	NADPH	NADPH	NNP
cord-339752-o6atz33c	193	23	oxidase	oxidase	NN
cord-339752-o6atz33c	193	24	and	and	CC
cord-339752-o6atz33c	193	25	renal	renal	JJ
cord-339752-o6atz33c	193	26	vascular	vascular	JJ
cord-339752-o6atz33c	193	27	dysfunction	dysfunction	NN
cord-339752-o6atz33c	193	28	in	in	IN
cord-339752-o6atz33c	193	29	diabetic	diabetic	JJ
cord-339752-o6atz33c	193	30	hypertensive	hypertensive	JJ
cord-339752-o6atz33c	193	31	rats	rat	NNS
cord-339752-o6atz33c	194	1	Angiotensin-(1	angiotensin-(1	JJ
cord-339752-o6atz33c	194	2	-	-	HYPH
cord-339752-o6atz33c	194	3	7	7	CD
cord-339752-o6atz33c	194	4	)	)	-RRB-
cord-339752-o6atz33c	194	5	inhibits	inhibit	VBZ
cord-339752-o6atz33c	194	6	allergic	allergic	JJ
cord-339752-o6atz33c	194	7	inflammation	inflammation	NN
cord-339752-o6atz33c	194	8	,	,	,
cord-339752-o6atz33c	194	9	via	via	IN
cord-339752-o6atz33c	194	10	the	the	DT
cord-339752-o6atz33c	194	11	MAS1	MAS1	NNP
cord-339752-o6atz33c	194	12	receptor	receptor	NN
cord-339752-o6atz33c	194	13	,	,	,
cord-339752-o6atz33c	194	14	through	through	IN
cord-339752-o6atz33c	194	15	suppression	suppression	NN
cord-339752-o6atz33c	194	16	of	of	IN
cord-339752-o6atz33c	194	17	ERK1/2-and	ERK1/2-and	NNP
cord-339752-o6atz33c	194	18	NF	NF	NNP
cord-339752-o6atz33c	194	19	-	-	HYPH
cord-339752-o6atz33c	194	20	κB	κB	NNP
cord-339752-o6atz33c	194	21	-	-	HYPH
cord-339752-o6atz33c	194	22	dependent	dependent	JJ
cord-339752-o6atz33c	194	23	pathways	pathway	NNS
cord-339752-o6atz33c	195	1	Angiotensin-(1	angiotensin-(1	JJ
cord-339752-o6atz33c	195	2	-	-	HYPH
cord-339752-o6atz33c	195	3	7	7	CD
cord-339752-o6atz33c	195	4	)	)	-RRB-
cord-339752-o6atz33c	195	5	-7	-7	.
cord-339752-o6atz33c	195	6	)	)	-RRB-
cord-339752-o6atz33c	195	7	is	be	VBZ
cord-339752-o6atz33c	195	8	an	an	DT
cord-339752-o6atz33c	195	9	endogenous	endogenous	JJ
cord-339752-o6atz33c	195	10	ligand	ligand	NN
cord-339752-o6atz33c	195	11	for	for	IN
cord-339752-o6atz33c	195	12	the	the	DT
cord-339752-o6atz33c	195	13	G	G	NNP
cord-339752-o6atz33c	195	14	protein	protein	NN
cord-339752-o6atz33c	195	15	-	-	HYPH
cord-339752-o6atz33c	195	16	coupled	couple	VBN
cord-339752-o6atz33c	195	17	receptor	receptor	NN
cord-339752-o6atz33c	195	18	Mas	Mas	NNP
cord-339752-o6atz33c	195	19	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	195	20	-	-	HYPH
cord-339752-o6atz33c	195	21	converting	convert	VBG
cord-339752-o6atz33c	195	22	enzyme	enzyme	NN
cord-339752-o6atz33c	195	23	2	2	CD
cord-339752-o6atz33c	195	24	as	as	IN
cord-339752-o6atz33c	195	25	a	a	DT
cord-339752-o6atz33c	195	26	therapeutic	therapeutic	JJ
cord-339752-o6atz33c	195	27	target	target	NN
cord-339752-o6atz33c	195	28	for	for	IN
cord-339752-o6atz33c	195	29	heart	heart	NN
cord-339752-o6atz33c	195	30	failure	failure	NN
cord-339752-o6atz33c	196	1	Circulating	circulate	VBG
cord-339752-o6atz33c	196	2	activities	activity	NNS
cord-339752-o6atz33c	196	3	of	of	IN
cord-339752-o6atz33c	196	4	angiotensin	angiotensin	NN
cord-339752-o6atz33c	196	5	-	-	HYPH
cord-339752-o6atz33c	196	6	converting	convert	VBG
cord-339752-o6atz33c	196	7	enzyme	enzyme	NN
cord-339752-o6atz33c	196	8	,	,	,
cord-339752-o6atz33c	196	9	its	-PRON-	PRP$
cord-339752-o6atz33c	196	10	homolog	homolog	NN
cord-339752-o6atz33c	196	11	,	,	,
cord-339752-o6atz33c	196	12	angiotensin	angiotensin	NN
cord-339752-o6atz33c	196	13	-	-	HYPH
cord-339752-o6atz33c	196	14	converting	convert	VBG
cord-339752-o6atz33c	196	15	enzyme	enzyme	NN
cord-339752-o6atz33c	196	16	2	2	CD
cord-339752-o6atz33c	196	17	,	,	,
cord-339752-o6atz33c	196	18	and	and	CC
cord-339752-o6atz33c	196	19	neprilysin	neprilysin	NNP
cord-339752-o6atz33c	196	20	in	in	IN
cord-339752-o6atz33c	196	21	a	a	DT
cord-339752-o6atz33c	196	22	family	family	NN
cord-339752-o6atz33c	196	23	study	study	NN
cord-339752-o6atz33c	197	1	Circulating	circulate	VBG
cord-339752-o6atz33c	197	2	angiotensin	angiotensin	NN
cord-339752-o6atz33c	197	3	-	-	HYPH
cord-339752-o6atz33c	197	4	converting	convert	VBG
cord-339752-o6atz33c	197	5	enzyme	enzyme	NN
cord-339752-o6atz33c	197	6	2	2	CD
cord-339752-o6atz33c	197	7	activity	activity	NN
cord-339752-o6atz33c	197	8	in	in	IN
cord-339752-o6atz33c	197	9	patients	patient	NNS
cord-339752-o6atz33c	197	10	with	with	IN
cord-339752-o6atz33c	197	11	chronic	chronic	JJ
cord-339752-o6atz33c	197	12	kidney	kidney	NN
cord-339752-o6atz33c	197	13	disease	disease	NN
cord-339752-o6atz33c	197	14	without	without	IN
cord-339752-o6atz33c	197	15	previous	previous	JJ
cord-339752-o6atz33c	197	16	history	history	NN
cord-339752-o6atz33c	197	17	of	of	IN
cord-339752-o6atz33c	197	18	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	197	19	disease	disease	NN
cord-339752-o6atz33c	197	20	Expression	expression	NN
cord-339752-o6atz33c	197	21	of	of	IN
cord-339752-o6atz33c	197	22	ACE	ACE	NNP
cord-339752-o6atz33c	197	23	and	and	CC
cord-339752-o6atz33c	197	24	ACE2	ACE2	NNP
cord-339752-o6atz33c	197	25	in	in	IN
cord-339752-o6atz33c	197	26	patients	patient	NNS
cord-339752-o6atz33c	197	27	with	with	IN
cord-339752-o6atz33c	197	28	hypertensive	hypertensive	JJ
cord-339752-o6atz33c	197	29	nephrosclerosis	nephrosclerosis	NN
cord-339752-o6atz33c	198	1	A	a	DT
cord-339752-o6atz33c	198	2	review	review	NN
cord-339752-o6atz33c	198	3	of	of	IN
cord-339752-o6atz33c	198	4	urinary	urinary	JJ
cord-339752-o6atz33c	198	5	angiotensin	angiotensin	NNP
cord-339752-o6atz33c	198	6	converting	convert	VBG
cord-339752-o6atz33c	198	7	enzyme	enzyme	NN
cord-339752-o6atz33c	198	8	2	2	CD
cord-339752-o6atz33c	198	9	in	in	IN
cord-339752-o6atz33c	198	10	diabetes	diabetes	NN
cord-339752-o6atz33c	198	11	and	and	CC
cord-339752-o6atz33c	198	12	diabetic	diabetic	JJ
cord-339752-o6atz33c	198	13	nephropathy	nephropathy	NN
cord-339752-o6atz33c	198	14	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	198	15	II	II	NNP
cord-339752-o6atz33c	198	16	revisited	revisit	VBD
cord-339752-o6atz33c	198	17	:	:	:
cord-339752-o6atz33c	198	18	New	new	JJ
cord-339752-o6atz33c	198	19	roles	role	NNS
cord-339752-o6atz33c	198	20	in	in	IN
cord-339752-o6atz33c	198	21	inflammation	inflammation	NN
cord-339752-o6atz33c	198	22	,	,	,
cord-339752-o6atz33c	198	23	immunology	immunology	NN
cord-339752-o6atz33c	198	24	and	and	CC
cord-339752-o6atz33c	198	25	aging	age	VBG
cord-339752-o6atz33c	198	26	Identification	identification	NN
cord-339752-o6atz33c	198	27	of	of	IN
cord-339752-o6atz33c	198	28	splenic	splenic	JJ
cord-339752-o6atz33c	198	29	reservoir	reservoir	NN
cord-339752-o6atz33c	198	30	monocytes	monocyte	NNS
cord-339752-o6atz33c	198	31	and	and	CC
cord-339752-o6atz33c	198	32	their	-PRON-	PRP$
cord-339752-o6atz33c	198	33	deployment	deployment	NN
cord-339752-o6atz33c	198	34	to	to	IN
cord-339752-o6atz33c	198	35	inflammatory	inflammatory	JJ
cord-339752-o6atz33c	198	36	sites	site	NNS
cord-339752-o6atz33c	199	1	Genetic	Genetic	NNP
cord-339752-o6atz33c	199	2	Ace2	Ace2	NNP
cord-339752-o6atz33c	199	3	deficiency	deficiency	NN
cord-339752-o6atz33c	199	4	accentuates	accentuate	VBZ
cord-339752-o6atz33c	199	5	vascular	vascular	JJ
cord-339752-o6atz33c	199	6	inflammation	inflammation	NN
cord-339752-o6atz33c	199	7	and	and	CC
cord-339752-o6atz33c	199	8	atherosclerosis	atherosclerosis	NN
cord-339752-o6atz33c	199	9	in	in	IN
cord-339752-o6atz33c	199	10	the	the	DT
cord-339752-o6atz33c	199	11	ApoE	ApoE	NNPS
cord-339752-o6atz33c	199	12	knockout	knockout	NN
cord-339752-o6atz33c	199	13	mouse	mouse	NN
cord-339752-o6atz33c	199	14	Enhanced	Enhanced	NNP
cord-339752-o6atz33c	199	15	angiotensin	angiotensin	NN
cord-339752-o6atz33c	199	16	II	II	NNP
cord-339752-o6atz33c	199	17	-	-	HYPH
cord-339752-o6atz33c	199	18	induced	induce	VBN
cord-339752-o6atz33c	199	19	cardiac	cardiac	JJ
cord-339752-o6atz33c	199	20	and	and	CC
cord-339752-o6atz33c	199	21	aortic	aortic	JJ
cord-339752-o6atz33c	199	22	remodeling	remodeling	NN
cord-339752-o6atz33c	199	23	in	in	IN
cord-339752-o6atz33c	199	24	ACE2	ACE2	NNP
cord-339752-o6atz33c	199	25	knockout	knockout	NN
cord-339752-o6atz33c	199	26	mice	mouse	NNS
cord-339752-o6atz33c	200	1	The	the	DT
cord-339752-o6atz33c	200	2	Anti	anti	JJ
cord-339752-o6atz33c	200	3	-	-	JJ
cord-339752-o6atz33c	200	4	Inflammatory	inflammatory	JJ
cord-339752-o6atz33c	200	5	Potential	potential	NN
cord-339752-o6atz33c	200	6	of	of	IN
cord-339752-o6atz33c	200	7	ACE2	ACE2	NNP
cord-339752-o6atz33c	200	8	/	/	SYM
cord-339752-o6atz33c	200	9	Angiotensin-(1	Angiotensin-(1	NNP
cord-339752-o6atz33c	200	10	-	-	HYPH
cord-339752-o6atz33c	200	11	7)/Mas	7)/Mas	NNP
cord-339752-o6atz33c	200	12	Receptor	Receptor	NNP
cord-339752-o6atz33c	200	13	Axis	Axis	NNP
cord-339752-o6atz33c	200	14	:	:	:
cord-339752-o6atz33c	200	15	Evidence	evidence	NN
cord-339752-o6atz33c	200	16	from	from	IN
cord-339752-o6atz33c	200	17	Basic	basic	JJ
cord-339752-o6atz33c	200	18	and	and	CC
cord-339752-o6atz33c	200	19	Clinical	Clinical	NNP
cord-339752-o6atz33c	200	20	Research	Research	NNP
cord-339752-o6atz33c	200	21	ACE2	ACE2	NNP
cord-339752-o6atz33c	200	22	links	link	NNS
cord-339752-o6atz33c	200	23	amino	amino	NN
cord-339752-o6atz33c	200	24	acid	acid	NN
cord-339752-o6atz33c	200	25	malnutrition	malnutrition	NN
cord-339752-o6atz33c	200	26	to	to	IN
cord-339752-o6atz33c	200	27	microbial	microbial	JJ
cord-339752-o6atz33c	200	28	ecology	ecology	NN
cord-339752-o6atz33c	200	29	and	and	CC
cord-339752-o6atz33c	200	30	intestinal	intestinal	JJ
cord-339752-o6atz33c	200	31	inflammation	inflammation	NN
cord-339752-o6atz33c	200	32	Expression	expression	NN
cord-339752-o6atz33c	200	33	and	and	CC
cord-339752-o6atz33c	200	34	regulation	regulation	NN
cord-339752-o6atz33c	200	35	of	of	IN
cord-339752-o6atz33c	200	36	the	the	DT
cord-339752-o6atz33c	200	37	neutral	neutral	JJ
cord-339752-o6atz33c	200	38	amino	amino	NN
cord-339752-o6atz33c	200	39	acid	acid	NN
cord-339752-o6atz33c	200	40	transporter	transporter	NN
cord-339752-o6atz33c	200	41	B0AT1	B0AT1	NNP
cord-339752-o6atz33c	200	42	in	in	IN
cord-339752-o6atz33c	200	43	rat	rat	NN
cord-339752-o6atz33c	200	44	small	small	JJ
cord-339752-o6atz33c	200	45	intestine	intestine	NN
cord-339752-o6atz33c	200	46	Structure	Structure	NNP
cord-339752-o6atz33c	200	47	of	of	IN
cord-339752-o6atz33c	200	48	dimeric	dimeric	JJ
cord-339752-o6atz33c	200	49	full	full	JJ
cord-339752-o6atz33c	200	50	-	-	HYPH
cord-339752-o6atz33c	200	51	length	length	NN
cord-339752-o6atz33c	200	52	human	human	JJ
cord-339752-o6atz33c	200	53	ACE2	ACE2	NNP
cord-339752-o6atz33c	200	54	in	in	IN
cord-339752-o6atz33c	200	55	complex	complex	NN
cord-339752-o6atz33c	200	56	with	with	IN
cord-339752-o6atz33c	200	57	B	b	NN
cord-339752-o6atz33c	200	58	0	0	CD
cord-339752-o6atz33c	200	59	AT1	at1	NN
cord-339752-o6atz33c	200	60	.	.	.
cord-339752-o6atz33c	201	1	bioRxiv	biorxiv	DT
cord-339752-o6atz33c	201	2	2020	2020	CD
cord-339752-o6atz33c	201	3	Gross	gross	JJ
cord-339752-o6atz33c	201	4	examination	examination	NN
cord-339752-o6atz33c	201	5	report	report	NN
cord-339752-o6atz33c	201	6	of	of	IN
cord-339752-o6atz33c	201	7	a	a	DT
cord-339752-o6atz33c	201	8	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	201	9	death	death	NN
cord-339752-o6atz33c	201	10	autopsy	autopsy	JJ
cord-339752-o6atz33c	201	11	Pathological	pathological	JJ
cord-339752-o6atz33c	201	12	findings	finding	NNS
cord-339752-o6atz33c	201	13	of	of	IN
cord-339752-o6atz33c	201	14	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	201	15	associated	associate	VBN
cord-339752-o6atz33c	201	16	with	with	IN
cord-339752-o6atz33c	201	17	acute	acute	JJ
cord-339752-o6atz33c	201	18	respiratory	respiratory	JJ
cord-339752-o6atz33c	201	19	distress	distress	NN
cord-339752-o6atz33c	201	20	syndrome	syndrome	NN
cord-339752-o6atz33c	201	21	Organ	Organ	NNP
cord-339752-o6atz33c	201	22	distribution	distribution	NN
cord-339752-o6atz33c	201	23	of	of	IN
cord-339752-o6atz33c	201	24	severe	severe	JJ
cord-339752-o6atz33c	201	25	acute	acute	JJ
cord-339752-o6atz33c	201	26	respiratory	respiratory	JJ
cord-339752-o6atz33c	201	27	syndrome	syndrome	NN
cord-339752-o6atz33c	201	28	(	(	-LRB-
cord-339752-o6atz33c	201	29	SARS	SARS	NNP
cord-339752-o6atz33c	201	30	)	)	-RRB-
cord-339752-o6atz33c	201	31	associated	associate	VBD
cord-339752-o6atz33c	201	32	coronavirus	coronavirus	NN
cord-339752-o6atz33c	201	33	(	(	-LRB-
cord-339752-o6atz33c	201	34	SARS	SARS	NNP
cord-339752-o6atz33c	201	35	-	-	HYPH
cord-339752-o6atz33c	201	36	CoV	CoV	NNP
cord-339752-o6atz33c	201	37	)	)	-RRB-
cord-339752-o6atz33c	201	38	in	in	IN
cord-339752-o6atz33c	201	39	SARS	SARS	NNP
cord-339752-o6atz33c	201	40	patients	patient	NNS
cord-339752-o6atz33c	201	41	:	:	:
cord-339752-o6atz33c	201	42	Implications	implication	NNS
cord-339752-o6atz33c	201	43	for	for	IN
cord-339752-o6atz33c	201	44	pathogenesis	pathogenesis	NN
cord-339752-o6atz33c	201	45	and	and	CC
cord-339752-o6atz33c	201	46	virus	virus	NN
cord-339752-o6atz33c	201	47	transmission	transmission	NN
cord-339752-o6atz33c	201	48	pathways	pathway	NNS
cord-339752-o6atz33c	201	49	Renin	Renin	NNP
cord-339752-o6atz33c	201	50	-	-	HYPH
cord-339752-o6atz33c	201	51	Angiotensin	angiotensin	NN
cord-339752-o6atz33c	201	52	-	-	HYPH
cord-339752-o6atz33c	201	53	aldosterone	aldosterone	NN
cord-339752-o6atz33c	201	54	system	system	NN
cord-339752-o6atz33c	201	55	in	in	IN
cord-339752-o6atz33c	201	56	diabetes	diabetes	NN
cord-339752-o6atz33c	201	57	and	and	CC
cord-339752-o6atz33c	201	58	hypertension	hypertension	NN
cord-339752-o6atz33c	201	59	Use	Use	NNP
cord-339752-o6atz33c	201	60	of	of	IN
cord-339752-o6atz33c	201	61	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	201	62	receptor	receptor	NN
cord-339752-o6atz33c	201	63	blockers	blocker	NNS
cord-339752-o6atz33c	201	64	in	in	IN
cord-339752-o6atz33c	201	65	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	201	66	protection	protection	NN
cord-339752-o6atz33c	201	67	:	:	:
cord-339752-o6atz33c	202	1	Current	current	JJ
cord-339752-o6atz33c	202	2	evidence	evidence	NN
cord-339752-o6atz33c	202	3	and	and	CC
cord-339752-o6atz33c	202	4	future	future	JJ
cord-339752-o6atz33c	202	5	directions	direction	NNS
cord-339752-o6atz33c	202	6	2020	2020	CD
cord-339752-o6atz33c	202	7	,	,	,
cord-339752-o6atz33c	202	8	NEJMoa2002032	NEJMoa2002032	NNP
cord-339752-o6atz33c	202	9	.	.	.
cord-339752-o6atz33c	203	1	[	[	-LRB-
cord-339752-o6atz33c	203	2	CrossRef	CrossRef	NNP
cord-339752-o6atz33c	203	3	]	]	-RRB-
cord-339752-o6atz33c	203	4	48	48	CD
cord-339752-o6atz33c	203	5	.	.	.
cord-339752-o6atz33c	204	1	Identification	identification	NN
cord-339752-o6atz33c	204	2	of	of	IN
cord-339752-o6atz33c	204	3	an	an	DT
cord-339752-o6atz33c	204	4	Existing	exist	VBG
cord-339752-o6atz33c	204	5	Japanese	japanese	JJ
cord-339752-o6atz33c	204	6	Pancreatitis	Pancreatitis	NNP
cord-339752-o6atz33c	204	7	Drug	Drug	NNP
cord-339752-o6atz33c	204	8	,	,	,
cord-339752-o6atz33c	204	9	Nafamostat	Nafamostat	NNP
cord-339752-o6atz33c	204	10	,	,	,
cord-339752-o6atz33c	204	11	Which	which	WDT
cord-339752-o6atz33c	204	12	is	be	VBZ
cord-339752-o6atz33c	204	13	Expected	expect	VBN
cord-339752-o6atz33c	204	14	to	to	TO
cord-339752-o6atz33c	204	15	Prevent	prevent	VB
cord-339752-o6atz33c	204	16	the	the	DT
cord-339752-o6atz33c	204	17	Transmission	Transmission	NNP
cord-339752-o6atz33c	204	18	of	of	IN
cord-339752-o6atz33c	204	19	New	New	NNP
cord-339752-o6atz33c	204	20	Coronavirus	Coronavirus	NNP
cord-339752-o6atz33c	204	21	Infection	Infection	NNP
cord-339752-o6atz33c	204	22	(	(	-LRB-
cord-339752-o6atz33c	204	23	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	204	24	)	)	-RRB-
cord-339752-o6atz33c	204	25	Diagnostic	Diagnostic	NNP
cord-339752-o6atz33c	204	26	Utility	Utility	NNP
cord-339752-o6atz33c	204	27	of	of	IN
cord-339752-o6atz33c	204	28	Clinical	Clinical	NNP
cord-339752-o6atz33c	204	29	Laboratory	Laboratory	NNP
cord-339752-o6atz33c	204	30	Data	Data	NNP
cord-339752-o6atz33c	204	31	Determinations	Determinations	NNPS
cord-339752-o6atz33c	204	32	for	for	IN
cord-339752-o6atz33c	204	33	Patients	patient	NNS
cord-339752-o6atz33c	204	34	with	with	IN
cord-339752-o6atz33c	204	35	the	the	DT
cord-339752-o6atz33c	204	36	Severe	severe	JJ
cord-339752-o6atz33c	204	37	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	204	38	Clinical	Clinical	NNP
cord-339752-o6atz33c	204	39	Features	Features	NNPS
cord-339752-o6atz33c	204	40	and	and	CC
cord-339752-o6atz33c	204	41	Treatment	Treatment	NNP
cord-339752-o6atz33c	204	42	of	of	IN
cord-339752-o6atz33c	204	43	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	204	44	Patients	Patients	NNPS
cord-339752-o6atz33c	204	45	in	in	IN
cord-339752-o6atz33c	204	46	Northeast	Northeast	NNP
cord-339752-o6atz33c	204	47	Chongqing	Chongqing	NNP
cord-339752-o6atz33c	205	1	COVID-19	covid-19	VB
cord-339752-o6atz33c	205	2	and	and	CC
cord-339752-o6atz33c	205	3	the	the	DT
cord-339752-o6atz33c	205	4	cardiovascular	cardiovascular	JJ
cord-339752-o6atz33c	205	5	system	system	NN
cord-339752-o6atz33c	205	6	Are	be	VBP
cord-339752-o6atz33c	205	7	patients	patient	NNS
cord-339752-o6atz33c	205	8	with	with	IN
cord-339752-o6atz33c	205	9	hypertension	hypertension	NN
cord-339752-o6atz33c	205	10	and	and	CC
cord-339752-o6atz33c	205	11	diabetes	diabetes	NN
cord-339752-o6atz33c	205	12	mellitus	mellitus	NN
cord-339752-o6atz33c	205	13	at	at	IN
cord-339752-o6atz33c	205	14	increased	increase	VBN
cord-339752-o6atz33c	205	15	risk	risk	NN
cord-339752-o6atz33c	205	16	for	for	IN
cord-339752-o6atz33c	205	17	COVID-19	covid-19	JJ
cord-339752-o6atz33c	205	18	infection	infection	NN
cord-339752-o6atz33c	205	19	?	?	.
cord-339752-o6atz33c	206	1	A	a	DT
cord-339752-o6atz33c	206	2	crucial	crucial	JJ
cord-339752-o6atz33c	206	3	role	role	NN
cord-339752-o6atz33c	206	4	of	of	IN
cord-339752-o6atz33c	206	5	angiotensin	angiotensin	NN
cord-339752-o6atz33c	206	6	converting	convert	VBG
cord-339752-o6atz33c	206	7	enzyme	enzyme	NN
cord-339752-o6atz33c	206	8	2	2	CD
cord-339752-o6atz33c	206	9	(	(	-LRB-
cord-339752-o6atz33c	206	10	ACE2	ACE2	NNP
cord-339752-o6atz33c	206	11	)	)	-RRB-
cord-339752-o6atz33c	206	12	in	in	IN
cord-339752-o6atz33c	206	13	SARS	SARS	NNP
cord-339752-o6atz33c	206	14	coronavirus	coronavirus	NN
cord-339752-o6atz33c	206	15	-	-	HYPH
cord-339752-o6atz33c	206	16	induced	induce	VBN
cord-339752-o6atz33c	206	17	lung	lung	NN
cord-339752-o6atz33c	206	18	injury	injury	NN
cord-339752-o6atz33c	206	19	Angiotensin	Angiotensin	NNP
cord-339752-o6atz33c	206	20	-	-	HYPH
cord-339752-o6atz33c	206	21	converting	convert	VBG
cord-339752-o6atz33c	206	22	enzyme	enzyme	NN
cord-339752-o6atz33c	206	23	2	2	CD
cord-339752-o6atz33c	206	24	protects	protect	VBZ
cord-339752-o6atz33c	206	25	from	from	IN
cord-339752-o6atz33c	206	26	severe	severe	JJ
cord-339752-o6atz33c	206	27	acute	acute	JJ
cord-339752-o6atz33c	206	28	lung	lung	NN
cord-339752-o6atz33c	206	29	failure	failure	NN
cord-339752-o6atz33c	207	1	SARS	SARS	NNP
cord-339752-o6atz33c	207	2	-	-	HYPH
cord-339752-o6atz33c	207	3	CoV	CoV	NNP
cord-339752-o6atz33c	207	4	replicates	replicate	NNS
cord-339752-o6atz33c	207	5	in	in	IN
cord-339752-o6atz33c	207	6	primary	primary	JJ
cord-339752-o6atz33c	207	7	human	human	JJ
cord-339752-o6atz33c	207	8	alveolar	alveolar	NN
cord-339752-o6atz33c	207	9	type	type	NN
cord-339752-o6atz33c	207	10	II	II	NNP
cord-339752-o6atz33c	207	11	cell	cell	NN
cord-339752-o6atz33c	207	12	cultures	culture	NNS
cord-339752-o6atz33c	207	13	but	but	CC
cord-339752-o6atz33c	207	14	not	not	RB
cord-339752-o6atz33c	207	15	in	in	IN
cord-339752-o6atz33c	207	16	type	type	NN
cord-339752-o6atz33c	207	17	I	i	NN
cord-339752-o6atz33c	207	18	-	-	HYPH
cord-339752-o6atz33c	207	19	like	like	JJ
cord-339752-o6atz33c	207	20	cells	cell	NNS
cord-339752-o6atz33c	207	21	Histopathologic	Histopathologic	NNP
cord-339752-o6atz33c	207	22	Changes	Changes	NNPS
cord-339752-o6atz33c	207	23	and	and	CC
cord-339752-o6atz33c	207	24	SARS	SARS	NNP
cord-339752-o6atz33c	207	25	-	-	HYPH
cord-339752-o6atz33c	207	26	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	208	1	Immunostaining	immunostaine	VBG
cord-339752-o6atz33c	208	2	in	in	IN
cord-339752-o6atz33c	208	3	the	the	DT
cord-339752-o6atz33c	208	4	Lung	Lung	NNP
cord-339752-o6atz33c	208	5	of	of	IN
cord-339752-o6atz33c	208	6	a	a	DT
cord-339752-o6atz33c	208	7	Patient	Patient	NNP
cord-339752-o6atz33c	208	8	With	with	IN
cord-339752-o6atz33c	208	9	COVID-19	COVID-19	NNP
cord-339752-o6atz33c	208	10	Inhibition	Inhibition	NNP
cord-339752-o6atz33c	208	11	of	of	IN
cord-339752-o6atz33c	208	12	SARS	SARS	NNP
cord-339752-o6atz33c	208	13	-	-	HYPH
cord-339752-o6atz33c	208	14	CoV-2	CoV-2	NNP
cord-339752-o6atz33c	208	15	infections	infection	NNS
cord-339752-o6atz33c	208	16	in	in	IN
cord-339752-o6atz33c	208	17	engineered	engineer	VBN
cord-339752-o6atz33c	208	18	human	human	JJ
cord-339752-o6atz33c	208	19	tissues	tissue	NNS
cord-339752-o6atz33c	208	20	using	use	VBG
cord-339752-o6atz33c	208	21	clinical	clinical	JJ
cord-339752-o6atz33c	208	22	-	-	HYPH
cord-339752-o6atz33c	208	23	grade	grade	NN
cord-339752-o6atz33c	208	24	soluble	soluble	JJ
cord-339752-o6atz33c	208	25	human	human	JJ
cord-339752-o6atz33c	208	26	ACE2	ace2	NN
cord-339752-o6atz33c	209	1	This	this	DT
cord-339752-o6atz33c	209	2	article	article	NN
cord-339752-o6atz33c	209	3	is	be	VBZ
cord-339752-o6atz33c	209	4	an	an	DT
cord-339752-o6atz33c	209	5	open	open	JJ
cord-339752-o6atz33c	209	6	access	access	NN
cord-339752-o6atz33c	209	7	article	article	NN
cord-339752-o6atz33c	209	8	distributed	distribute	VBN
cord-339752-o6atz33c	209	9	under	under	IN
cord-339752-o6atz33c	209	10	the	the	DT
cord-339752-o6atz33c	209	11	terms	term	NNS
cord-339752-o6atz33c	209	12	and	and	CC
cord-339752-o6atz33c	209	13	conditions	condition	NNS
cord-339752-o6atz33c	209	14	of	of	IN
cord-339752-o6atz33c	209	15	the	the	DT
cord-339752-o6atz33c	209	16	Creative	Creative	NNP
cord-339752-o6atz33c	209	17	Commons	Commons	NNP
cord-339752-o6atz33c	209	18	Attribution	Attribution	NNP
cord-339752-o6atz33c	209	19	(	(	-LRB-
cord-339752-o6atz33c	209	20	CC	CC	NNP
cord-339752-o6atz33c	209	21	BY	by	IN
cord-339752-o6atz33c	209	22	)	)	-RRB-
cord-339752-o6atz33c	209	23	license	license	NN
cord-339752-o6atz33c	209	24	The	the	DT
cord-339752-o6atz33c	209	25	authors	author	NNS
cord-339752-o6atz33c	209	26	would	would	MD
cord-339752-o6atz33c	209	27	like	like	VB
cord-339752-o6atz33c	209	28	to	to	IN
cord-339752-o6atz33c	209	29	Nathaniel	Nathaniel	NNP
cord-339752-o6atz33c	209	30	Green	Green	NNP
cord-339752-o6atz33c	209	31	's	's	POS
cord-339752-o6atz33c	209	32	proofreading	proofreading	NN
cord-339752-o6atz33c	209	33	.	.	.
cord-339752-o6atz33c	210	1	The	the	DT
cord-339752-o6atz33c	210	2	authors	author	NNS
cord-339752-o6atz33c	210	3	declare	declare	VBP
cord-339752-o6atz33c	210	4	no	no	DT
cord-339752-o6atz33c	210	5	conflict	conflict	NN
cord-339752-o6atz33c	210	6	of	of	IN
cord-339752-o6atz33c	210	7	interest	interest	NN
cord-339752-o6atz33c	210	8	.	.	.