id	sid	tid	token	lemma	pos
cord-332165-31tbc31x	1	1	key	key	JJ
cord-332165-31tbc31x	1	2	:	:	:
cord-332165-31tbc31x	1	3	cord-332165	cord-332165	NNP
cord-332165-31tbc31x	1	4	-	-	HYPH
cord-332165-31tbc31x	1	5	31tbc31x	31tbc31x	CD
cord-332165-31tbc31x	1	6	authors	author	NNS
cord-332165-31tbc31x	1	7	:	:	:
cord-332165-31tbc31x	1	8	Rustmeier	Rustmeier	NNP
cord-332165-31tbc31x	1	9	,	,	,
cord-332165-31tbc31x	1	10	Nils	Nils	NNP
cord-332165-31tbc31x	1	11	H.	H.	NNP
cord-332165-31tbc31x	1	12	;	;	:
cord-332165-31tbc31x	1	13	Strebl	Strebl	NNP
cord-332165-31tbc31x	1	14	,	,	,
cord-332165-31tbc31x	1	15	Michael	Michael	NNP
cord-332165-31tbc31x	1	16	;	;	:
cord-332165-31tbc31x	1	17	Stehle	Stehle	NNP
cord-332165-31tbc31x	1	18	,	,	,
cord-332165-31tbc31x	1	19	Thilo	Thilo	NNP
cord-332165-31tbc31x	2	1	title	title	NN
cord-332165-31tbc31x	2	2	:	:	:
cord-332165-31tbc31x	3	1	The	the	DT
cord-332165-31tbc31x	3	2	Symmetry	Symmetry	NNP
cord-332165-31tbc31x	3	3	of	of	IN
cord-332165-31tbc31x	3	4	Viral	Viral	NNP
cord-332165-31tbc31x	3	5	Sialic	Sialic	NNP
cord-332165-31tbc31x	3	6	Acid	acid	NN
cord-332165-31tbc31x	3	7	Binding	Binding	NNP
cord-332165-31tbc31x	3	8	Sites	site	NNS
cord-332165-31tbc31x	3	9	—	—	:
cord-332165-31tbc31x	3	10	Implications	implication	NNS
cord-332165-31tbc31x	3	11	for	for	IN
cord-332165-31tbc31x	3	12	Antiviral	Antiviral	NNP
cord-332165-31tbc31x	3	13	Strategies	Strategies	NNPS
cord-332165-31tbc31x	3	14	date	date	NN
cord-332165-31tbc31x	3	15	:	:	:
cord-332165-31tbc31x	3	16	2019	2019	CD
cord-332165-31tbc31x	3	17	-	-	SYM
cord-332165-31tbc31x	3	18	10	10	CD
cord-332165-31tbc31x	3	19	-	-	SYM
cord-332165-31tbc31x	3	20	14	14	CD
cord-332165-31tbc31x	3	21	journal	journal	NN
cord-332165-31tbc31x	3	22	:	:	:
cord-332165-31tbc31x	4	1	Viruses	virus	NNS
cord-332165-31tbc31x	4	2	DOI	DOI	NNP
cord-332165-31tbc31x	4	3	:	:	:
cord-332165-31tbc31x	5	1	10.3390	10.3390	CD
cord-332165-31tbc31x	5	2	/	/	SYM
cord-332165-31tbc31x	5	3	v11100947	v11100947	NNP
cord-332165-31tbc31x	5	4	sha	sha	NNP
cord-332165-31tbc31x	5	5	:	:	:
cord-332165-31tbc31x	6	1	ab6ea04273419326cd53f7e41f36e6120a63f18b	ab6ea04273419326cd53f7e41f36e6120a63f18b	NNP
cord-332165-31tbc31x	6	2	doc_id	doc_id	CD
cord-332165-31tbc31x	6	3	:	:	:
cord-332165-31tbc31x	6	4	332165	332165	CD
cord-332165-31tbc31x	6	5	cord_uid	cord_uid	NNS
cord-332165-31tbc31x	6	6	:	:	:
cord-332165-31tbc31x	7	1	31tbc31x	31tbc31x	NNP
cord-332165-31tbc31x	7	2	Virus	virus	NN
cord-332165-31tbc31x	7	3	infections	infection	NNS
cord-332165-31tbc31x	7	4	are	be	VBP
cord-332165-31tbc31x	7	5	initiated	initiate	VBN
cord-332165-31tbc31x	7	6	by	by	IN
cord-332165-31tbc31x	7	7	the	the	DT
cord-332165-31tbc31x	7	8	attachment	attachment	NN
cord-332165-31tbc31x	7	9	of	of	IN
cord-332165-31tbc31x	7	10	the	the	DT
cord-332165-31tbc31x	7	11	viral	viral	JJ
cord-332165-31tbc31x	7	12	particle	particle	NN
cord-332165-31tbc31x	7	13	to	to	IN
cord-332165-31tbc31x	7	14	protein	protein	NN
cord-332165-31tbc31x	7	15	or	or	CC
cord-332165-31tbc31x	7	16	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	7	17	receptors	receptor	NNS
cord-332165-31tbc31x	7	18	on	on	IN
cord-332165-31tbc31x	7	19	the	the	DT
cord-332165-31tbc31x	7	20	host	host	NN
cord-332165-31tbc31x	7	21	cell	cell	NN
cord-332165-31tbc31x	7	22	.	.	.
cord-332165-31tbc31x	8	1	Sialic	Sialic	NNP
cord-332165-31tbc31x	8	2	acid	acid	NN
cord-332165-31tbc31x	8	3	-	-	HYPH
cord-332165-31tbc31x	8	4	bearing	bear	VBG
cord-332165-31tbc31x	8	5	glycan	glycan	NN
cord-332165-31tbc31x	8	6	structures	structure	NNS
cord-332165-31tbc31x	8	7	are	be	VBP
cord-332165-31tbc31x	8	8	prominently	prominently	RB
cord-332165-31tbc31x	8	9	displayed	display	VBN
cord-332165-31tbc31x	8	10	at	at	IN
cord-332165-31tbc31x	8	11	the	the	DT
cord-332165-31tbc31x	8	12	cell	cell	NN
cord-332165-31tbc31x	8	13	surface	surface	NN
cord-332165-31tbc31x	8	14	,	,	,
cord-332165-31tbc31x	8	15	and	and	CC
cord-332165-31tbc31x	8	16	,	,	,
cord-332165-31tbc31x	8	17	consequently	consequently	RB
cord-332165-31tbc31x	8	18	,	,	,
cord-332165-31tbc31x	8	19	these	these	DT
cord-332165-31tbc31x	8	20	structures	structure	NNS
cord-332165-31tbc31x	8	21	can	can	MD
cord-332165-31tbc31x	8	22	function	function	VB
cord-332165-31tbc31x	8	23	as	as	IN
cord-332165-31tbc31x	8	24	receptors	receptor	NNS
cord-332165-31tbc31x	8	25	for	for	IN
cord-332165-31tbc31x	8	26	a	a	DT
cord-332165-31tbc31x	8	27	large	large	JJ
cord-332165-31tbc31x	8	28	number	number	NN
cord-332165-31tbc31x	8	29	of	of	IN
cord-332165-31tbc31x	8	30	diverse	diverse	JJ
cord-332165-31tbc31x	8	31	viruses	virus	NNS
cord-332165-31tbc31x	8	32	.	.	.
cord-332165-31tbc31x	9	1	Structural	structural	JJ
cord-332165-31tbc31x	9	2	biology	biology	NN
cord-332165-31tbc31x	9	3	research	research	NN
cord-332165-31tbc31x	9	4	has	have	VBZ
cord-332165-31tbc31x	9	5	helped	help	VBN
cord-332165-31tbc31x	9	6	to	to	TO
cord-332165-31tbc31x	9	7	establish	establish	VB
cord-332165-31tbc31x	9	8	the	the	DT
cord-332165-31tbc31x	9	9	molecular	molecular	JJ
cord-332165-31tbc31x	9	10	bases	basis	NNS
cord-332165-31tbc31x	9	11	for	for	IN
cord-332165-31tbc31x	9	12	many	many	JJ
cord-332165-31tbc31x	9	13	virus	virus	NN
cord-332165-31tbc31x	9	14	–	–	:
cord-332165-31tbc31x	9	15	sialic	sialic	JJ
cord-332165-31tbc31x	9	16	acid	acid	NN
cord-332165-31tbc31x	9	17	interactions	interaction	NNS
cord-332165-31tbc31x	9	18	.	.	.
cord-332165-31tbc31x	10	1	Due	due	IN
cord-332165-31tbc31x	10	2	to	to	IN
cord-332165-31tbc31x	10	3	the	the	DT
cord-332165-31tbc31x	10	4	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	10	5	532	532	CD
cord-332165-31tbc31x	10	6	point	point	NN
cord-332165-31tbc31x	10	7	group	group	NN
cord-332165-31tbc31x	10	8	symmetry	symmetry	NN
cord-332165-31tbc31x	10	9	that	that	WDT
cord-332165-31tbc31x	10	10	underlies	underlie	VBZ
cord-332165-31tbc31x	10	11	many	many	JJ
cord-332165-31tbc31x	10	12	viral	viral	JJ
cord-332165-31tbc31x	10	13	capsids	capsid	NNS
cord-332165-31tbc31x	10	14	,	,	,
cord-332165-31tbc31x	10	15	the	the	DT
cord-332165-31tbc31x	10	16	receptor	receptor	NN
cord-332165-31tbc31x	10	17	binding	bind	VBG
cord-332165-31tbc31x	10	18	sites	site	NNS
cord-332165-31tbc31x	10	19	are	be	VBP
cord-332165-31tbc31x	10	20	frequently	frequently	RB
cord-332165-31tbc31x	10	21	arranged	arrange	VBN
cord-332165-31tbc31x	10	22	in	in	IN
cord-332165-31tbc31x	10	23	a	a	DT
cord-332165-31tbc31x	10	24	highly	highly	RB
cord-332165-31tbc31x	10	25	symmetric	symmetric	JJ
cord-332165-31tbc31x	10	26	fashion	fashion	NN
cord-332165-31tbc31x	10	27	and	and	CC
cord-332165-31tbc31x	10	28	linked	link	VBN
cord-332165-31tbc31x	10	29	by	by	IN
cord-332165-31tbc31x	10	30	five	five	CD
cord-332165-31tbc31x	10	31	-	-	RB
cord-332165-31tbc31x	10	32	fold	fold	JJ
cord-332165-31tbc31x	10	33	,	,	,
cord-332165-31tbc31x	10	34	three	three	CD
cord-332165-31tbc31x	10	35	-	-	HYPH
cord-332165-31tbc31x	10	36	fold	fold	NN
cord-332165-31tbc31x	10	37	,	,	,
cord-332165-31tbc31x	10	38	or	or	CC
cord-332165-31tbc31x	10	39	two	two	CD
cord-332165-31tbc31x	10	40	-	-	HYPH
cord-332165-31tbc31x	10	41	fold	fold	JJ
cord-332165-31tbc31x	10	42	rotation	rotation	NN
cord-332165-31tbc31x	10	43	axes	axis	NNS
cord-332165-31tbc31x	10	44	.	.	.
cord-332165-31tbc31x	11	1	For	for	IN
cord-332165-31tbc31x	11	2	the	the	DT
cord-332165-31tbc31x	11	3	inhibition	inhibition	NN
cord-332165-31tbc31x	11	4	of	of	IN
cord-332165-31tbc31x	11	5	viral	viral	JJ
cord-332165-31tbc31x	11	6	attachment	attachment	NN
cord-332165-31tbc31x	11	7	,	,	,
cord-332165-31tbc31x	11	8	one	one	CD
cord-332165-31tbc31x	11	9	emerging	emerge	VBG
cord-332165-31tbc31x	11	10	strategy	strategy	NN
cord-332165-31tbc31x	11	11	is	be	VBZ
cord-332165-31tbc31x	11	12	based	base	VBN
cord-332165-31tbc31x	11	13	on	on	IN
cord-332165-31tbc31x	11	14	developing	develop	VBG
cord-332165-31tbc31x	11	15	multivalent	multivalent	JJ
cord-332165-31tbc31x	11	16	sialic	sialic	JJ
cord-332165-31tbc31x	11	17	acid	acid	NN
cord-332165-31tbc31x	11	18	-	-	HYPH
cord-332165-31tbc31x	11	19	based	base	VBN
cord-332165-31tbc31x	11	20	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	11	21	that	that	WDT
cord-332165-31tbc31x	11	22	can	can	MD
cord-332165-31tbc31x	11	23	simultaneously	simultaneously	RB
cord-332165-31tbc31x	11	24	engage	engage	VB
cord-332165-31tbc31x	11	25	several	several	JJ
cord-332165-31tbc31x	11	26	of	of	IN
cord-332165-31tbc31x	11	27	these	these	DT
cord-332165-31tbc31x	11	28	binding	bind	VBG
cord-332165-31tbc31x	11	29	sites	site	NNS
cord-332165-31tbc31x	11	30	,	,	,
cord-332165-31tbc31x	11	31	thus	thus	RB
cord-332165-31tbc31x	11	32	binding	bind	VBG
cord-332165-31tbc31x	11	33	viral	viral	JJ
cord-332165-31tbc31x	11	34	capsids	capsid	NNS
cord-332165-31tbc31x	11	35	with	with	IN
cord-332165-31tbc31x	11	36	high	high	JJ
cord-332165-31tbc31x	11	37	avidity	avidity	NN
cord-332165-31tbc31x	11	38	.	.	.
cord-332165-31tbc31x	12	1	In	in	IN
cord-332165-31tbc31x	12	2	this	this	DT
cord-332165-31tbc31x	12	3	review	review	NN
cord-332165-31tbc31x	12	4	,	,	,
cord-332165-31tbc31x	12	5	we	-PRON-	PRP
cord-332165-31tbc31x	12	6	will	will	MD
cord-332165-31tbc31x	12	7	evaluate	evaluate	VB
cord-332165-31tbc31x	12	8	the	the	DT
cord-332165-31tbc31x	12	9	structures	structure	NNS
cord-332165-31tbc31x	12	10	of	of	IN
cord-332165-31tbc31x	12	11	non	non	JJ
cord-332165-31tbc31x	12	12	-	-	JJ
cord-332165-31tbc31x	12	13	enveloped	enveloped	JJ
cord-332165-31tbc31x	12	14	virus	virus	NN
cord-332165-31tbc31x	12	15	capsid	capsid	NN
cord-332165-31tbc31x	12	16	proteins	protein	NNS
cord-332165-31tbc31x	12	17	bound	bind	VBN
cord-332165-31tbc31x	12	18	to	to	IN
cord-332165-31tbc31x	12	19	sialylated	sialylate	VBN
cord-332165-31tbc31x	12	20	glycan	glycan	NN
cord-332165-31tbc31x	12	21	receptors	receptor	NNS
cord-332165-31tbc31x	12	22	and	and	CC
cord-332165-31tbc31x	12	23	discuss	discuss	VB
cord-332165-31tbc31x	12	24	the	the	DT
cord-332165-31tbc31x	12	25	potential	potential	NN
cord-332165-31tbc31x	12	26	of	of	IN
cord-332165-31tbc31x	12	27	these	these	DT
cord-332165-31tbc31x	12	28	structures	structure	NNS
cord-332165-31tbc31x	12	29	for	for	IN
cord-332165-31tbc31x	12	30	the	the	DT
cord-332165-31tbc31x	12	31	development	development	NN
cord-332165-31tbc31x	12	32	of	of	IN
cord-332165-31tbc31x	12	33	potent	potent	JJ
cord-332165-31tbc31x	12	34	antiviral	antiviral	JJ
cord-332165-31tbc31x	12	35	attachment	attachment	NN
cord-332165-31tbc31x	12	36	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	12	37	.	.	.
cord-332165-31tbc31x	13	1	The	the	DT
cord-332165-31tbc31x	13	2	cell	cell	NN
cord-332165-31tbc31x	13	3	membranes	membrane	NNS
cord-332165-31tbc31x	13	4	of	of	IN
cord-332165-31tbc31x	13	5	eukaryotes	eukaryote	NNS
cord-332165-31tbc31x	13	6	are	be	VBP
cord-332165-31tbc31x	13	7	decorated	decorate	VBN
cord-332165-31tbc31x	13	8	with	with	IN
cord-332165-31tbc31x	13	9	a	a	DT
cord-332165-31tbc31x	13	10	large	large	JJ
cord-332165-31tbc31x	13	11	number	number	NN
cord-332165-31tbc31x	13	12	of	of	IN
cord-332165-31tbc31x	13	13	chemically	chemically	RB
cord-332165-31tbc31x	13	14	and	and	CC
cord-332165-31tbc31x	13	15	structurally	structurally	RB
cord-332165-31tbc31x	13	16	diverse	diverse	JJ
cord-332165-31tbc31x	13	17	carbohydrates	carbohydrate	NNS
cord-332165-31tbc31x	13	18	.	.	.
cord-332165-31tbc31x	14	1	These	these	DT
cord-332165-31tbc31x	14	2	so	so	RB
cord-332165-31tbc31x	14	3	-	-	HYPH
cord-332165-31tbc31x	14	4	called	call	VBN
cord-332165-31tbc31x	14	5	glycans	glycan	NNS
cord-332165-31tbc31x	14	6	form	form	VBP
cord-332165-31tbc31x	14	7	a	a	DT
cord-332165-31tbc31x	14	8	protective	protective	JJ
cord-332165-31tbc31x	14	9	layer	layer	NN
cord-332165-31tbc31x	14	10	at	at	IN
cord-332165-31tbc31x	14	11	the	the	DT
cord-332165-31tbc31x	14	12	interface	interface	NN
cord-332165-31tbc31x	14	13	between	between	IN
cord-332165-31tbc31x	14	14	a	a	DT
cord-332165-31tbc31x	14	15	cell	cell	NN
cord-332165-31tbc31x	14	16	and	and	CC
cord-332165-31tbc31x	14	17	its	-PRON-	PRP$
cord-332165-31tbc31x	14	18	environment	environment	NN
cord-332165-31tbc31x	14	19	.	.	.
cord-332165-31tbc31x	15	1	Components	component	NNS
cord-332165-31tbc31x	15	2	of	of	IN
cord-332165-31tbc31x	15	3	this	this	DT
cord-332165-31tbc31x	15	4	layer	layer	NN
cord-332165-31tbc31x	15	5	are	be	VBP
cord-332165-31tbc31x	15	6	synthesized	synthesize	VBN
cord-332165-31tbc31x	15	7	and	and	CC
cord-332165-31tbc31x	15	8	assembled	assemble	VBN
cord-332165-31tbc31x	15	9	by	by	IN
cord-332165-31tbc31x	15	10	a	a	DT
cord-332165-31tbc31x	15	11	large	large	JJ
cord-332165-31tbc31x	15	12	set	set	NN
cord-332165-31tbc31x	15	13	of	of	IN
cord-332165-31tbc31x	15	14	enzymes	enzyme	NNS
cord-332165-31tbc31x	15	15	that	that	WDT
cord-332165-31tbc31x	15	16	differ	differ	VBP
cord-332165-31tbc31x	15	17	among	among	IN
cord-332165-31tbc31x	15	18	species	specie	NNS
cord-332165-31tbc31x	15	19	,	,	,
cord-332165-31tbc31x	15	20	thus	thus	RB
cord-332165-31tbc31x	15	21	helping	help	VBG
cord-332165-31tbc31x	15	22	to	to	TO
cord-332165-31tbc31x	15	23	provide	provide	VB
cord-332165-31tbc31x	15	24	host	host	NN
cord-332165-31tbc31x	15	25	-	-	HYPH
cord-332165-31tbc31x	15	26	specific	specific	JJ
cord-332165-31tbc31x	15	27	glycan	glycan	NN
cord-332165-31tbc31x	15	28	structures	structure	NNS
cord-332165-31tbc31x	15	29	.	.	.
cord-332165-31tbc31x	16	1	Despite	despite	IN
cord-332165-31tbc31x	16	2	some	some	DT
cord-332165-31tbc31x	16	3	differences	difference	NNS
cord-332165-31tbc31x	16	4	,	,	,
cord-332165-31tbc31x	16	5	the	the	DT
cord-332165-31tbc31x	16	6	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	16	7	building	building	NN
cord-332165-31tbc31x	16	8	blocks	block	NNS
cord-332165-31tbc31x	16	9	of	of	IN
cord-332165-31tbc31x	16	10	the	the	DT
cord-332165-31tbc31x	16	11	glycan	glycan	NN
cord-332165-31tbc31x	16	12	layer	layer	NN
cord-332165-31tbc31x	16	13	(	(	-LRB-
cord-332165-31tbc31x	16	14	monosaccharides	monosaccharide	NNS
cord-332165-31tbc31x	16	15	)	)	-RRB-
cord-332165-31tbc31x	16	16	are	be	VBP
cord-332165-31tbc31x	16	17	largely	largely	RB
cord-332165-31tbc31x	16	18	identical	identical	JJ
cord-332165-31tbc31x	16	19	in	in	IN
cord-332165-31tbc31x	16	20	all	all	DT
cord-332165-31tbc31x	16	21	cases	case	NNS
cord-332165-31tbc31x	16	22	.	.	.
cord-332165-31tbc31x	17	1	Commonly	commonly	RB
cord-332165-31tbc31x	17	2	found	find	VBN
cord-332165-31tbc31x	17	3	monosaccharides	monosaccharide	NNS
cord-332165-31tbc31x	17	4	in	in	IN
cord-332165-31tbc31x	17	5	glycan	glycan	NN
cord-332165-31tbc31x	17	6	structures	structure	NNS
cord-332165-31tbc31x	17	7	are	be	VBP
cord-332165-31tbc31x	17	8	glucose	glucose	NN
cord-332165-31tbc31x	17	9	(	(	-LRB-
cord-332165-31tbc31x	17	10	Glc	Glc	NNP
cord-332165-31tbc31x	17	11	)	)	-RRB-
cord-332165-31tbc31x	17	12	,	,	,
cord-332165-31tbc31x	17	13	galactose	galactose	NN
cord-332165-31tbc31x	17	14	(	(	-LRB-
cord-332165-31tbc31x	17	15	Gal	Gal	NNP
cord-332165-31tbc31x	17	16	)	)	-RRB-
cord-332165-31tbc31x	17	17	,	,	,
cord-332165-31tbc31x	17	18	their	-PRON-	PRP$
cord-332165-31tbc31x	17	19	N	n	CD
cord-332165-31tbc31x	17	20	-	-	HYPH
cord-332165-31tbc31x	17	21	acetylated	acetylate	VBN
cord-332165-31tbc31x	17	22	forms	form	NNS
cord-332165-31tbc31x	17	23	N	N	NNP
cord-332165-31tbc31x	17	24	-	-	HYPH
cord-332165-31tbc31x	17	25	acetylglucosamine	acetylglucosamine	NNP
cord-332165-31tbc31x	17	26	(	(	-LRB-
cord-332165-31tbc31x	17	27	GlcNAc	GlcNAc	NNP
cord-332165-31tbc31x	17	28	)	)	-RRB-
cord-332165-31tbc31x	17	29	and	and	CC
cord-332165-31tbc31x	17	30	N	n	CD
cord-332165-31tbc31x	17	31	-	-	HYPH
cord-332165-31tbc31x	17	32	acetylgalactosamine	acetylgalactosamine	NNP
cord-332165-31tbc31x	17	33	(	(	-LRB-
cord-332165-31tbc31x	17	34	GalNAc	GalNAc	NNP
cord-332165-31tbc31x	17	35	)	)	-RRB-
cord-332165-31tbc31x	17	36	,	,	,
cord-332165-31tbc31x	17	37	and	and	CC
cord-332165-31tbc31x	17	38	mannose	mannose	NN
cord-332165-31tbc31x	17	39	(	(	-LRB-
cord-332165-31tbc31x	17	40	Man	man	NN
cord-332165-31tbc31x	17	41	)	)	-RRB-
cord-332165-31tbc31x	17	42	.	.	.
cord-332165-31tbc31x	18	1	These	these	DT
cord-332165-31tbc31x	18	2	building	building	NN
cord-332165-31tbc31x	18	3	blocks	block	NNS
cord-332165-31tbc31x	18	4	constitute	constitute	VBP
cord-332165-31tbc31x	18	5	the	the	DT
cord-332165-31tbc31x	18	6	bulk	bulk	NN
cord-332165-31tbc31x	18	7	of	of	IN
cord-332165-31tbc31x	18	8	most	most	JJS
cord-332165-31tbc31x	18	9	glycans	glycan	NNS
cord-332165-31tbc31x	18	10	.	.	.
cord-332165-31tbc31x	19	1	However	however	RB
cord-332165-31tbc31x	19	2	,	,	,
cord-332165-31tbc31x	19	3	two	two	CD
cord-332165-31tbc31x	19	4	particularly	particularly	RB
cord-332165-31tbc31x	19	5	important	important	JJ
cord-332165-31tbc31x	19	6	sugar	sugar	NN
cord-332165-31tbc31x	19	7	classes	class	NNS
cord-332165-31tbc31x	19	8	are	be	VBP
cord-332165-31tbc31x	19	9	missing	miss	VBG
cord-332165-31tbc31x	19	10	here	here	RB
cord-332165-31tbc31x	19	11	:	:	:
cord-332165-31tbc31x	19	12	fucoses	fucose	NNS
cord-332165-31tbc31x	19	13	and	and	CC
cord-332165-31tbc31x	19	14	sialic	sialic	JJ
cord-332165-31tbc31x	19	15	acids	acid	NNS
cord-332165-31tbc31x	19	16	.	.	.
cord-332165-31tbc31x	20	1	While	while	IN
cord-332165-31tbc31x	20	2	Glc(-NAc	glc(-nac	NN
cord-332165-31tbc31x	20	3	)	)	-RRB-
cord-332165-31tbc31x	20	4	and	and	CC
cord-332165-31tbc31x	20	5	Gal(-NAc	Gal(-NAc	NNP
cord-332165-31tbc31x	20	6	)	)	-RRB-
cord-332165-31tbc31x	20	7	are	be	VBP
cord-332165-31tbc31x	20	8	usually	usually	RB
cord-332165-31tbc31x	20	9	components	component	NNS
cord-332165-31tbc31x	20	10	of	of	IN
cord-332165-31tbc31x	20	11	the	the	DT
cord-332165-31tbc31x	20	12	scaffold	scaffold	NN
cord-332165-31tbc31x	20	13	,	,	,
cord-332165-31tbc31x	20	14	fucose	fucose	NNP
cord-332165-31tbc31x	20	15	(	(	-LRB-
cord-332165-31tbc31x	20	16	Fuc	Fuc	NNP
cord-332165-31tbc31x	20	17	)	)	-RRB-
cord-332165-31tbc31x	20	18	and	and	CC
cord-332165-31tbc31x	20	19	sialic	sialic	JJ
cord-332165-31tbc31x	20	20	acids	acid	NNS
cord-332165-31tbc31x	20	21	are	be	VBP
cord-332165-31tbc31x	20	22	often	often	RB
cord-332165-31tbc31x	20	23	added	add	VBN
cord-332165-31tbc31x	20	24	as	as	IN
cord-332165-31tbc31x	20	25	head	head	NN
cord-332165-31tbc31x	20	26	groups	group	NNS
cord-332165-31tbc31x	20	27	to	to	IN
cord-332165-31tbc31x	20	28	a	a	DT
cord-332165-31tbc31x	20	29	glycan	glycan	NN
cord-332165-31tbc31x	20	30	.	.	.
cord-332165-31tbc31x	21	1	While	while	IN
cord-332165-31tbc31x	21	2	fucose	fucose	NNP
cord-332165-31tbc31x	21	3	is	be	VBZ
cord-332165-31tbc31x	21	4	,	,	,
cord-332165-31tbc31x	21	5	for	for	IN
cord-332165-31tbc31x	21	6	example	example	NN
cord-332165-31tbc31x	21	7	,	,	,
cord-332165-31tbc31x	21	8	an	an	DT
cord-332165-31tbc31x	21	9	important	important	JJ
cord-332165-31tbc31x	21	10	determinant	determinant	NN
cord-332165-31tbc31x	21	11	in	in	IN
cord-332165-31tbc31x	21	12	histo	histo	JJ
cord-332165-31tbc31x	21	13	-	-	HYPH
cord-332165-31tbc31x	21	14	blood	blood	NN
cord-332165-31tbc31x	21	15	group	group	NN
cord-332165-31tbc31x	21	16	antigens	antigen	NNS
cord-332165-31tbc31x	21	17	(	(	-LRB-
cord-332165-31tbc31x	21	18	HBGA	HBGA	NNP
cord-332165-31tbc31x	21	19	)	)	-RRB-
cord-332165-31tbc31x	21	20	,	,	,
cord-332165-31tbc31x	21	21	sialic	sialic	JJ
cord-332165-31tbc31x	21	22	acids	acid	NNS
cord-332165-31tbc31x	21	23	are	be	VBP
cord-332165-31tbc31x	21	24	major	major	JJ
cord-332165-31tbc31x	21	25	components	component	NNS
cord-332165-31tbc31x	21	26	of	of	IN
cord-332165-31tbc31x	21	27	the	the	DT
cord-332165-31tbc31x	21	28	glycan	glycan	NN
cord-332165-31tbc31x	21	29	portions	portion	NNS
cord-332165-31tbc31x	21	30	of	of	IN
cord-332165-31tbc31x	21	31	gangliosides	ganglioside	NNS
cord-332165-31tbc31x	21	32	and	and	CC
cord-332165-31tbc31x	21	33	the	the	DT
cord-332165-31tbc31x	21	34	glycan	glycan	NN
cord-332165-31tbc31x	21	35	structures	structure	NNS
cord-332165-31tbc31x	21	36	of	of	IN
cord-332165-31tbc31x	21	37	many	many	JJ
cord-332165-31tbc31x	21	38	membranous	membranous	JJ
cord-332165-31tbc31x	21	39	proteins	protein	NNS
cord-332165-31tbc31x	21	40	in	in	IN
cord-332165-31tbc31x	21	41	eukaryotes	eukaryote	NNS
cord-332165-31tbc31x	21	42	.	.	.
cord-332165-31tbc31x	22	1	Sialic	Sialic	NNP
cord-332165-31tbc31x	22	2	acids	acid	NNS
cord-332165-31tbc31x	22	3	are	be	VBP
cord-332165-31tbc31x	22	4	based	base	VBN
cord-332165-31tbc31x	22	5	on	on	IN
cord-332165-31tbc31x	22	6	a	a	DT
cord-332165-31tbc31x	22	7	nine	nine	CD
cord-332165-31tbc31x	22	8	-	-	HYPH
cord-332165-31tbc31x	22	9	carbon	carbon	NN
cord-332165-31tbc31x	22	10	acidic	acidic	JJ
cord-332165-31tbc31x	22	11	α	α	NN
cord-332165-31tbc31x	22	12	-	-	HYPH
cord-332165-31tbc31x	22	13	keto	keto	NNP
cord-332165-31tbc31x	22	14	sugar	sugar	NN
cord-332165-31tbc31x	22	15	framework	framework	NN
cord-332165-31tbc31x	22	16	(	(	-LRB-
cord-332165-31tbc31x	22	17	Figure	figure	NN
cord-332165-31tbc31x	22	18	1	1	CD
cord-332165-31tbc31x	22	19	)	)	-RRB-
cord-332165-31tbc31x	22	20	.	.	.
cord-332165-31tbc31x	23	1	Due	due	IN
cord-332165-31tbc31x	23	2	to	to	IN
cord-332165-31tbc31x	23	3	their	-PRON-	PRP$
cord-332165-31tbc31x	23	4	anionic	anionic	JJ
cord-332165-31tbc31x	23	5	nature	nature	NN
cord-332165-31tbc31x	23	6	,	,	,
cord-332165-31tbc31x	23	7	sialic	sialic	JJ
cord-332165-31tbc31x	23	8	acids	acid	NNS
cord-332165-31tbc31x	23	9	contribute	contribute	VBP
cord-332165-31tbc31x	23	10	to	to	IN
cord-332165-31tbc31x	23	11	the	the	DT
cord-332165-31tbc31x	23	12	negative	negative	JJ
cord-332165-31tbc31x	23	13	net	net	JJ
cord-332165-31tbc31x	23	14	charge	charge	NN
cord-332165-31tbc31x	23	15	of	of	IN
cord-332165-31tbc31x	23	16	the	the	DT
cord-332165-31tbc31x	23	17	cell	cell	NN
cord-332165-31tbc31x	23	18	surface	surface	NN
cord-332165-31tbc31x	23	19	.	.	.
cord-332165-31tbc31x	24	1	Sialic	Sialic	NNP
cord-332165-31tbc31x	24	2	acids	acid	NNS
cord-332165-31tbc31x	24	3	are	be	VBP
cord-332165-31tbc31x	24	4	abundant	abundant	JJ
cord-332165-31tbc31x	24	5	in	in	IN
cord-332165-31tbc31x	24	6	the	the	DT
cord-332165-31tbc31x	24	7	animal	animal	NN
cord-332165-31tbc31x	24	8	kingdom	kingdom	NN
cord-332165-31tbc31x	24	9	and	and	CC
cord-332165-31tbc31x	24	10	are	be	VBP
cord-332165-31tbc31x	24	11	found	find	VBN
cord-332165-31tbc31x	24	12	in	in	IN
cord-332165-31tbc31x	24	13	different	different	JJ
cord-332165-31tbc31x	24	14	forms	form	NNS
cord-332165-31tbc31x	24	15	.	.	.
cord-332165-31tbc31x	25	1	Their	-PRON-	PRP$
cord-332165-31tbc31x	25	2	most	most	RBS
cord-332165-31tbc31x	25	3	common	common	JJ
cord-332165-31tbc31x	25	4	form	form	NN
cord-332165-31tbc31x	25	5	is	be	VBZ
cord-332165-31tbc31x	25	6	N	n	CD
cord-332165-31tbc31x	25	7	-	-	HYPH
cord-332165-31tbc31x	25	8	acetylneuraminic	acetylneuraminic	JJ
cord-332165-31tbc31x	25	9	acid	acid	NN
cord-332165-31tbc31x	25	10	(	(	-LRB-
cord-332165-31tbc31x	25	11	Neu5Ac	Neu5Ac	NNP
cord-332165-31tbc31x	25	12	)	)	-RRB-
cord-332165-31tbc31x	25	13	,	,	,
cord-332165-31tbc31x	25	14	which	which	WDT
cord-332165-31tbc31x	25	15	also	also	RB
cord-332165-31tbc31x	25	16	constitutes	constitute	VBZ
cord-332165-31tbc31x	25	17	the	the	DT
cord-332165-31tbc31x	25	18	chemical	chemical	JJ
cord-332165-31tbc31x	25	19	basis	basis	NN
cord-332165-31tbc31x	25	20	for	for	IN
cord-332165-31tbc31x	25	21	other	other	JJ
cord-332165-31tbc31x	25	22	sialic	sialic	JJ
cord-332165-31tbc31x	25	23	acids	acid	NNS
cord-332165-31tbc31x	25	24	.	.	.
cord-332165-31tbc31x	26	1	The	the	DT
cord-332165-31tbc31x	26	2	hydroxylation	hydroxylation	NN
cord-332165-31tbc31x	26	3	of	of	IN
cord-332165-31tbc31x	26	4	the	the	DT
cord-332165-31tbc31x	26	5	N	N	NNP
cord-332165-31tbc31x	26	6	-	-	HYPH
cord-332165-31tbc31x	26	7	acetyl	acetyl	NNP
cord-332165-31tbc31x	26	8	group	group	NN
cord-332165-31tbc31x	26	9	of	of	IN
cord-332165-31tbc31x	26	10	Neu5Ac	Neu5Ac	NNP
cord-332165-31tbc31x	26	11	gives	give	VBZ
cord-332165-31tbc31x	26	12	rise	rise	NN
cord-332165-31tbc31x	26	13	to	to	IN
cord-332165-31tbc31x	26	14	N	n	CD
cord-332165-31tbc31x	26	15	-	-	HYPH
cord-332165-31tbc31x	26	16	glycolylneuraminic	glycolylneuraminic	NN
cord-332165-31tbc31x	26	17	acid	acid	NN
cord-332165-31tbc31x	26	18	(	(	-LRB-
cord-332165-31tbc31x	26	19	Neu5Gc	Neu5Gc	NNP
cord-332165-31tbc31x	26	20	)	)	-RRB-
cord-332165-31tbc31x	26	21	,	,	,
cord-332165-31tbc31x	26	22	another	another	DT
cord-332165-31tbc31x	26	23	commonly	commonly	RB
cord-332165-31tbc31x	26	24	found	find	VBD
cord-332165-31tbc31x	26	25	sialic	sialic	JJ
cord-332165-31tbc31x	26	26	acid	acid	NN
cord-332165-31tbc31x	26	27	in	in	IN
cord-332165-31tbc31x	26	28	animals	animal	NNS
cord-332165-31tbc31x	26	29	.	.	.
cord-332165-31tbc31x	27	1	While	while	IN
cord-332165-31tbc31x	27	2	Neu5Gc	Neu5Gc	NNP
cord-332165-31tbc31x	27	3	can	can	MD
cord-332165-31tbc31x	27	4	not	not	RB
cord-332165-31tbc31x	27	5	be	be	VB
cord-332165-31tbc31x	27	6	synthesized	synthesize	VBN
cord-332165-31tbc31x	27	7	in	in	IN
cord-332165-31tbc31x	27	8	humans	human	NNS
cord-332165-31tbc31x	27	9	due	due	JJ
cord-332165-31tbc31x	27	10	to	to	IN
cord-332165-31tbc31x	27	11	a	a	DT
cord-332165-31tbc31x	27	12	gene	gene	NN
cord-332165-31tbc31x	27	13	defect	defect	NN
cord-332165-31tbc31x	27	14	,	,	,
cord-332165-31tbc31x	27	15	humans	human	NNS
cord-332165-31tbc31x	27	16	Glycans	Glycans	NNPS
cord-332165-31tbc31x	27	17	terminating	terminate	VBG
cord-332165-31tbc31x	27	18	in	in	IN
cord-332165-31tbc31x	27	19	sialic	sialic	JJ
cord-332165-31tbc31x	27	20	acid	acid	NN
cord-332165-31tbc31x	27	21	are	be	VBP
cord-332165-31tbc31x	27	22	prominently	prominently	RB
cord-332165-31tbc31x	27	23	expressed	express	VBN
cord-332165-31tbc31x	27	24	at	at	IN
cord-332165-31tbc31x	27	25	the	the	DT
cord-332165-31tbc31x	27	26	cell	cell	NN
cord-332165-31tbc31x	27	27	surface	surface	NN
cord-332165-31tbc31x	27	28	.	.	.
cord-332165-31tbc31x	28	1	They	-PRON-	PRP
cord-332165-31tbc31x	28	2	are	be	VBP
cord-332165-31tbc31x	28	3	,	,	,
cord-332165-31tbc31x	28	4	therefore	therefore	RB
cord-332165-31tbc31x	28	5	,	,	,
cord-332165-31tbc31x	28	6	often	often	RB
cord-332165-31tbc31x	28	7	easily	easily	RB
cord-332165-31tbc31x	28	8	accessible	accessible	JJ
cord-332165-31tbc31x	28	9	and	and	CC
cord-332165-31tbc31x	28	10	serve	serve	VB
cord-332165-31tbc31x	28	11	as	as	IN
cord-332165-31tbc31x	28	12	the	the	DT
cord-332165-31tbc31x	28	13	initial	initial	JJ
cord-332165-31tbc31x	28	14	contact	contact	NN
cord-332165-31tbc31x	28	15	points	point	NNS
cord-332165-31tbc31x	28	16	for	for	IN
cord-332165-31tbc31x	28	17	many	many	JJ
cord-332165-31tbc31x	28	18	viruses	virus	NNS
cord-332165-31tbc31x	28	19	in	in	IN
cord-332165-31tbc31x	28	20	different	different	JJ
cord-332165-31tbc31x	28	21	families	family	NNS
cord-332165-31tbc31x	28	22	[	[	-LRB-
cord-332165-31tbc31x	28	23	6	6	CD
cord-332165-31tbc31x	28	24	,	,	,
cord-332165-31tbc31x	28	25	7	7	CD
cord-332165-31tbc31x	28	26	]	]	-RRB-
cord-332165-31tbc31x	28	27	.	.	.
cord-332165-31tbc31x	29	1	While	while	IN
cord-332165-31tbc31x	29	2	some	some	DT
cord-332165-31tbc31x	29	3	of	of	IN
cord-332165-31tbc31x	29	4	these	these	DT
cord-332165-31tbc31x	29	5	glycans	glycan	NNS
cord-332165-31tbc31x	29	6	function	function	VBP
cord-332165-31tbc31x	29	7	as	as	IN
cord-332165-31tbc31x	29	8	attachment	attachment	NN
cord-332165-31tbc31x	29	9	receptors	receptor	NNS
cord-332165-31tbc31x	29	10	to	to	TO
cord-332165-31tbc31x	29	11	simply	simply	RB
cord-332165-31tbc31x	29	12	tether	tether	VB
cord-332165-31tbc31x	29	13	a	a	DT
cord-332165-31tbc31x	29	14	virus	virus	NN
cord-332165-31tbc31x	29	15	to	to	IN
cord-332165-31tbc31x	29	16	the	the	DT
cord-332165-31tbc31x	29	17	target	target	NN
cord-332165-31tbc31x	29	18	cell	cell	NN
cord-332165-31tbc31x	29	19	membrane	membrane	NN
cord-332165-31tbc31x	29	20	,	,	,
cord-332165-31tbc31x	29	21	others	other	NNS
cord-332165-31tbc31x	29	22	act	act	VBP
cord-332165-31tbc31x	29	23	as	as	IN
cord-332165-31tbc31x	29	24	entry	entry	NN
cord-332165-31tbc31x	29	25	receptors	receptor	NNS
cord-332165-31tbc31x	29	26	and	and	CC
cord-332165-31tbc31x	29	27	mediate	mediate	VB
cord-332165-31tbc31x	29	28	binding	binding	NN
cord-332165-31tbc31x	29	29	of	of	IN
cord-332165-31tbc31x	29	30	the	the	DT
cord-332165-31tbc31x	29	31	virus	virus	NN
cord-332165-31tbc31x	29	32	,	,	,
cord-332165-31tbc31x	29	33	as	as	RB
cord-332165-31tbc31x	29	34	well	well	RB
cord-332165-31tbc31x	29	35	as	as	IN
cord-332165-31tbc31x	29	36	the	the	DT
cord-332165-31tbc31x	29	37	delivery	delivery	NN
cord-332165-31tbc31x	29	38	of	of	IN
cord-332165-31tbc31x	29	39	the	the	DT
cord-332165-31tbc31x	29	40	viral	viral	JJ
cord-332165-31tbc31x	29	41	genome	genome	NN
cord-332165-31tbc31x	29	42	into	into	IN
cord-332165-31tbc31x	29	43	the	the	DT
cord-332165-31tbc31x	29	44	cytoplasm	cytoplasm	NN
cord-332165-31tbc31x	29	45	.	.	.
cord-332165-31tbc31x	30	1	In	in	IN
cord-332165-31tbc31x	30	2	the	the	DT
cord-332165-31tbc31x	30	3	latter	latter	JJ
cord-332165-31tbc31x	30	4	case	case	NN
cord-332165-31tbc31x	30	5	,	,	,
cord-332165-31tbc31x	30	6	the	the	DT
cord-332165-31tbc31x	30	7	attachment	attachment	NN
cord-332165-31tbc31x	30	8	step	step	NN
cord-332165-31tbc31x	30	9	is	be	VBZ
cord-332165-31tbc31x	30	10	often	often	RB
cord-332165-31tbc31x	30	11	followed	follow	VBN
cord-332165-31tbc31x	30	12	by	by	IN
cord-332165-31tbc31x	30	13	the	the	DT
cord-332165-31tbc31x	30	14	recruitment	recruitment	NN
cord-332165-31tbc31x	30	15	of	of	IN
cord-332165-31tbc31x	30	16	secondary	secondary	JJ
cord-332165-31tbc31x	30	17	(	(	-LRB-
cord-332165-31tbc31x	30	18	co-)receptors	co-)receptor	NNS
cord-332165-31tbc31x	30	19	and	and	CC
cord-332165-31tbc31x	30	20	endocytosis	endocytosis	NN
cord-332165-31tbc31x	30	21	factors	factor	NNS
cord-332165-31tbc31x	30	22	,	,	,
cord-332165-31tbc31x	30	23	eventually	eventually	RB
cord-332165-31tbc31x	30	24	leading	lead	VBG
cord-332165-31tbc31x	30	25	to	to	IN
cord-332165-31tbc31x	30	26	cell	cell	NN
cord-332165-31tbc31x	30	27	entry	entry	NN
cord-332165-31tbc31x	30	28	of	of	IN
cord-332165-31tbc31x	30	29	the	the	DT
cord-332165-31tbc31x	30	30	virus	virus	NN
cord-332165-31tbc31x	30	31	particle	particle	NN
cord-332165-31tbc31x	30	32	or	or	CC
cord-332165-31tbc31x	30	33	its	-PRON-	PRP$
cord-332165-31tbc31x	30	34	components	component	NNS
cord-332165-31tbc31x	30	35	and	and	CC
cord-332165-31tbc31x	30	36	infection	infection	NN
cord-332165-31tbc31x	30	37	of	of	IN
cord-332165-31tbc31x	30	38	the	the	DT
cord-332165-31tbc31x	30	39	cell	cell	NN
cord-332165-31tbc31x	30	40	.	.	.
cord-332165-31tbc31x	31	1	Among	among	IN
cord-332165-31tbc31x	31	2	the	the	DT
cord-332165-31tbc31x	31	3	enveloped	envelop	VBN
cord-332165-31tbc31x	31	4	viruses	virus	NNS
cord-332165-31tbc31x	31	5	that	that	WDT
cord-332165-31tbc31x	31	6	recognize	recognize	VBP
cord-332165-31tbc31x	31	7	sialic	sialic	JJ
cord-332165-31tbc31x	31	8	acid	acid	NN
cord-332165-31tbc31x	31	9	-	-	HYPH
cord-332165-31tbc31x	31	10	containing	contain	VBG
cord-332165-31tbc31x	31	11	receptors	receptor	NNS
cord-332165-31tbc31x	31	12	are	be	VBP
cord-332165-31tbc31x	31	13	members	member	NNS
cord-332165-31tbc31x	31	14	of	of	IN
cord-332165-31tbc31x	31	15	the	the	DT
cord-332165-31tbc31x	31	16	families	family	NNS
cord-332165-31tbc31x	31	17	Coronaviridae	Coronaviridae	NNP
cord-332165-31tbc31x	31	18	,	,	,
cord-332165-31tbc31x	31	19	Paramyxoviridae	Paramyxoviridae	NNP
cord-332165-31tbc31x	31	20	and	and	CC
cord-332165-31tbc31x	31	21	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-332165-31tbc31x	31	22	[	[	-LRB-
cord-332165-31tbc31x	31	23	8	8	CD
cord-332165-31tbc31x	31	24	]	]	-RRB-
cord-332165-31tbc31x	31	25	[	[	-LRB-
cord-332165-31tbc31x	31	26	9	9	CD
cord-332165-31tbc31x	31	27	]	]	-RRB-
cord-332165-31tbc31x	31	28	[	[	-LRB-
cord-332165-31tbc31x	31	29	10	10	CD
cord-332165-31tbc31x	31	30	]	]	-RRB-
cord-332165-31tbc31x	31	31	[	[	-LRB-
cord-332165-31tbc31x	31	32	11	11	CD
cord-332165-31tbc31x	31	33	]	]	-RRB-
cord-332165-31tbc31x	31	34	[	[	-LRB-
cord-332165-31tbc31x	31	35	12	12	CD
cord-332165-31tbc31x	31	36	]	]	-RRB-
cord-332165-31tbc31x	31	37	.	.	.
cord-332165-31tbc31x	32	1	In	in	IN
cord-332165-31tbc31x	32	2	non	non	JJ
cord-332165-31tbc31x	32	3	-	-	JJ
cord-332165-31tbc31x	32	4	enveloped	enveloped	JJ
cord-332165-31tbc31x	32	5	viruses	virus	NNS
cord-332165-31tbc31x	32	6	,	,	,
cord-332165-31tbc31x	32	7	sialic	sialic	JJ
cord-332165-31tbc31x	32	8	acid	acid	NN
cord-332165-31tbc31x	32	9	-	-	HYPH
cord-332165-31tbc31x	32	10	containing	contain	VBG
cord-332165-31tbc31x	32	11	glycans	glycan	NNS
cord-332165-31tbc31x	32	12	serve	serve	VBP
cord-332165-31tbc31x	32	13	as	as	IN
cord-332165-31tbc31x	32	14	attachment	attachment	NN
cord-332165-31tbc31x	32	15	receptors	receptor	NNS
cord-332165-31tbc31x	32	16	for	for	IN
cord-332165-31tbc31x	32	17	members	member	NNS
cord-332165-31tbc31x	32	18	of	of	IN
cord-332165-31tbc31x	32	19	the	the	DT
cord-332165-31tbc31x	32	20	Parvoviridae	Parvoviridae	NNP
cord-332165-31tbc31x	32	21	,	,	,
cord-332165-31tbc31x	32	22	Picornaviridae	Picornaviridae	NNP
cord-332165-31tbc31x	32	23	,	,	,
cord-332165-31tbc31x	32	24	Caliciviridae	Caliciviridae	NNP
cord-332165-31tbc31x	32	25	,	,	,
cord-332165-31tbc31x	32	26	Polyomaviridae	Polyomaviridae	NNP
cord-332165-31tbc31x	32	27	,	,	,
cord-332165-31tbc31x	32	28	Reoviridiae	Reoviridiae	NNP
cord-332165-31tbc31x	32	29	,	,	,
cord-332165-31tbc31x	32	30	and	and	CC
cord-332165-31tbc31x	32	31	Adenoviridae	Adenoviridae	NNP
cord-332165-31tbc31x	32	32	[	[	-LRB-
cord-332165-31tbc31x	32	33	13	13	CD
cord-332165-31tbc31x	32	34	]	]	-RRB-
cord-332165-31tbc31x	33	1	[	[	-LRB-
cord-332165-31tbc31x	33	2	14	14	CD
cord-332165-31tbc31x	33	3	]	]	-RRB-
cord-332165-31tbc31x	34	1	[	[	-LRB-
cord-332165-31tbc31x	34	2	15	15	CD
cord-332165-31tbc31x	34	3	]	]	-RRB-
cord-332165-31tbc31x	34	4	[	[	-LRB-
cord-332165-31tbc31x	34	5	16	16	CD
cord-332165-31tbc31x	34	6	]	]	-RRB-
cord-332165-31tbc31x	34	7	[	[	-LRB-
cord-332165-31tbc31x	34	8	17	17	CD
cord-332165-31tbc31x	34	9	]	]	-RRB-
cord-332165-31tbc31x	34	10	[	[	-LRB-
cord-332165-31tbc31x	34	11	18	18	CD
cord-332165-31tbc31x	34	12	]	]	-RRB-
cord-332165-31tbc31x	34	13	[	[	-LRB-
cord-332165-31tbc31x	34	14	19	19	CD
cord-332165-31tbc31x	34	15	]	]	-RRB-
cord-332165-31tbc31x	35	1	[	[	-LRB-
cord-332165-31tbc31x	35	2	20	20	CD
cord-332165-31tbc31x	35	3	]	]	-RRB-
cord-332165-31tbc31x	35	4	[	[	-LRB-
cord-332165-31tbc31x	35	5	21	21	CD
cord-332165-31tbc31x	35	6	]	]	-RRB-
cord-332165-31tbc31x	36	1	[	[	-LRB-
cord-332165-31tbc31x	36	2	22	22	CD
cord-332165-31tbc31x	36	3	]	]	-RRB-
cord-332165-31tbc31x	36	4	[	[	-LRB-
cord-332165-31tbc31x	36	5	23	23	CD
cord-332165-31tbc31x	36	6	]	]	-RRB-
cord-332165-31tbc31x	37	1	[	[	-LRB-
cord-332165-31tbc31x	37	2	24	24	CD
cord-332165-31tbc31x	37	3	]	]	-RRB-
cord-332165-31tbc31x	37	4	[	[	-LRB-
cord-332165-31tbc31x	37	5	25	25	CD
cord-332165-31tbc31x	37	6	]	]	-RRB-
cord-332165-31tbc31x	37	7	[	[	-LRB-
cord-332165-31tbc31x	37	8	26	26	CD
cord-332165-31tbc31x	37	9	]	]	-RRB-
cord-332165-31tbc31x	37	10	.	.	.
cord-332165-31tbc31x	38	1	Structural	structural	JJ
cord-332165-31tbc31x	38	2	biology	biology	NN
cord-332165-31tbc31x	38	3	has	have	VBZ
cord-332165-31tbc31x	38	4	provided	provide	VBN
cord-332165-31tbc31x	38	5	precise	precise	JJ
cord-332165-31tbc31x	38	6	views	view	NNS
cord-332165-31tbc31x	38	7	of	of	IN
cord-332165-31tbc31x	38	8	how	how	WRB
cord-332165-31tbc31x	38	9	these	these	DT
cord-332165-31tbc31x	38	10	pathogens	pathogen	NNS
cord-332165-31tbc31x	38	11	interact	interact	VBP
cord-332165-31tbc31x	38	12	with	with	IN
cord-332165-31tbc31x	38	13	sialylated	sialylated	JJ
cord-332165-31tbc31x	38	14	glycans	glycan	NNS
cord-332165-31tbc31x	38	15	,	,	,
cord-332165-31tbc31x	38	16	and	and	CC
cord-332165-31tbc31x	38	17	although	although	IN
cord-332165-31tbc31x	38	18	the	the	DT
cord-332165-31tbc31x	38	19	binding	bind	VBG
cord-332165-31tbc31x	38	20	modes	mode	NNS
cord-332165-31tbc31x	38	21	differ	differ	VBP
cord-332165-31tbc31x	38	22	among	among	IN
cord-332165-31tbc31x	38	23	the	the	DT
cord-332165-31tbc31x	38	24	viruses	virus	NNS
cord-332165-31tbc31x	38	25	listed	list	VBN
cord-332165-31tbc31x	38	26	above	above	RB
cord-332165-31tbc31x	38	27	,	,	,
cord-332165-31tbc31x	38	28	several	several	JJ
cord-332165-31tbc31x	38	29	common	common	JJ
cord-332165-31tbc31x	38	30	principles	principle	NNS
cord-332165-31tbc31x	38	31	have	have	VBP
cord-332165-31tbc31x	38	32	emerged	emerge	VBN
cord-332165-31tbc31x	38	33	.	.	.
cord-332165-31tbc31x	39	1	(	(	-LRB-
cord-332165-31tbc31x	39	2	i	i	NN
cord-332165-31tbc31x	39	3	)	)	-RRB-
cord-332165-31tbc31x	40	1	The	the	DT
cord-332165-31tbc31x	40	2	viral	viral	JJ
cord-332165-31tbc31x	40	3	binding	bind	VBG
cord-332165-31tbc31x	40	4	sites	site	NNS
cord-332165-31tbc31x	40	5	for	for	IN
cord-332165-31tbc31x	40	6	sialylated	sialylated	JJ
cord-332165-31tbc31x	40	7	glycans	glycan	NNS
cord-332165-31tbc31x	40	8	are	be	VBP
cord-332165-31tbc31x	40	9	typically	typically	RB
cord-332165-31tbc31x	40	10	surface	surface	NN
cord-332165-31tbc31x	40	11	-	-	HYPH
cord-332165-31tbc31x	40	12	exposed	expose	VBN
cord-332165-31tbc31x	40	13	and	and	CC
cord-332165-31tbc31x	40	14	feature	feature	VBP
cord-332165-31tbc31x	40	15	a	a	DT
cord-332165-31tbc31x	40	16	small	small	JJ
cord-332165-31tbc31x	40	17	number	number	NN
cord-332165-31tbc31x	40	18	of	of	IN
cord-332165-31tbc31x	40	19	contacts	contact	NNS
cord-332165-31tbc31x	40	20	.	.	.
cord-332165-31tbc31x	41	1	The	the	DT
cord-332165-31tbc31x	41	2	affinities	affinity	NNS
cord-332165-31tbc31x	41	3	of	of	IN
cord-332165-31tbc31x	41	4	the	the	DT
cord-332165-31tbc31x	41	5	interactions	interaction	NNS
cord-332165-31tbc31x	41	6	are	be	VBP
cord-332165-31tbc31x	41	7	,	,	,
cord-332165-31tbc31x	41	8	therefore	therefore	RB
cord-332165-31tbc31x	41	9	,	,	,
cord-332165-31tbc31x	41	10	quite	quite	RB
cord-332165-31tbc31x	41	11	low	low	JJ
cord-332165-31tbc31x	41	12	(	(	-LRB-
cord-332165-31tbc31x	41	13	in	in	IN
cord-332165-31tbc31x	41	14	the	the	DT
cord-332165-31tbc31x	41	15	millimolar	millimolar	JJ
cord-332165-31tbc31x	41	16	range	range	NN
cord-332165-31tbc31x	41	17	)	)	-RRB-
cord-332165-31tbc31x	41	18	[	[	-LRB-
cord-332165-31tbc31x	41	19	27	27	CD
cord-332165-31tbc31x	41	20	]	]	-RRB-
cord-332165-31tbc31x	42	1	[	[	-LRB-
cord-332165-31tbc31x	42	2	28	28	CD
cord-332165-31tbc31x	42	3	]	]	-RRB-
cord-332165-31tbc31x	43	1	[	[	-LRB-
cord-332165-31tbc31x	43	2	29	29	CD
cord-332165-31tbc31x	43	3	]	]	-RRB-
cord-332165-31tbc31x	43	4	[	[	-LRB-
cord-332165-31tbc31x	43	5	30	30	CD
cord-332165-31tbc31x	43	6	]	]	-RRB-
cord-332165-31tbc31x	43	7	.	.	.
cord-332165-31tbc31x	44	1	Firm	firm	JJ
cord-332165-31tbc31x	44	2	adhesion	adhesion	NN
cord-332165-31tbc31x	44	3	of	of	IN
cord-332165-31tbc31x	44	4	the	the	DT
cord-332165-31tbc31x	44	5	virus	virus	NN
cord-332165-31tbc31x	44	6	to	to	IN
cord-332165-31tbc31x	44	7	the	the	DT
cord-332165-31tbc31x	44	8	cell	cell	NN
cord-332165-31tbc31x	44	9	surface	surface	NN
cord-332165-31tbc31x	44	10	is	be	VBZ
cord-332165-31tbc31x	44	11	achieved	achieve	VBN
cord-332165-31tbc31x	44	12	through	through	IN
cord-332165-31tbc31x	44	13	the	the	DT
cord-332165-31tbc31x	44	14	engagement	engagement	NN
cord-332165-31tbc31x	44	15	of	of	IN
cord-332165-31tbc31x	44	16	multiple	multiple	JJ
cord-332165-31tbc31x	44	17	receptors	receptor	NNS
cord-332165-31tbc31x	44	18	via	via	IN
cord-332165-31tbc31x	44	19	identical	identical	JJ
cord-332165-31tbc31x	44	20	binding	bind	VBG
cord-332165-31tbc31x	44	21	sites	site	NNS
cord-332165-31tbc31x	44	22	,	,	,
cord-332165-31tbc31x	44	23	which	which	WDT
cord-332165-31tbc31x	44	24	is	be	VBZ
cord-332165-31tbc31x	44	25	known	know	VBN
cord-332165-31tbc31x	44	26	as	as	IN
cord-332165-31tbc31x	44	27	avidity	avidity	NN
cord-332165-31tbc31x	44	28	.	.	.
cord-332165-31tbc31x	45	1	(	(	-LRB-
cord-332165-31tbc31x	45	2	ii	ii	NN
cord-332165-31tbc31x	45	3	)	)	-RRB-
cord-332165-31tbc31x	46	1	In	in	IN
cord-332165-31tbc31x	46	2	all	all	DT
cord-332165-31tbc31x	46	3	cases	case	NNS
cord-332165-31tbc31x	46	4	investigated	investigate	VBN
cord-332165-31tbc31x	46	5	to	to	IN
cord-332165-31tbc31x	46	6	date	date	NN
cord-332165-31tbc31x	46	7	,	,	,
cord-332165-31tbc31x	46	8	the	the	DT
cord-332165-31tbc31x	46	9	sialic	sialic	NN
cord-332165-31tbc31x	46	10	acid	acid	NN
cord-332165-31tbc31x	46	11	itself	-PRON-	PRP
cord-332165-31tbc31x	46	12	mediates	mediate	VBZ
cord-332165-31tbc31x	46	13	the	the	DT
cord-332165-31tbc31x	46	14	majority	majority	NN
cord-332165-31tbc31x	46	15	of	of	IN
cord-332165-31tbc31x	46	16	contacts	contact	NNS
cord-332165-31tbc31x	46	17	with	with	IN
cord-332165-31tbc31x	46	18	the	the	DT
cord-332165-31tbc31x	46	19	viral	viral	JJ
cord-332165-31tbc31x	46	20	capsid	capsid	NN
cord-332165-31tbc31x	46	21	,	,	,
cord-332165-31tbc31x	46	22	with	with	IN
cord-332165-31tbc31x	46	23	a	a	DT
cord-332165-31tbc31x	46	24	smaller	small	JJR
cord-332165-31tbc31x	46	25	number	number	NN
cord-332165-31tbc31x	46	26	of	of	IN
cord-332165-31tbc31x	46	27	additional	additional	JJ
cord-332165-31tbc31x	46	28	contacts	contact	NNS
cord-332165-31tbc31x	46	29	formed	form	VBN
cord-332165-31tbc31x	46	30	to	to	IN
cord-332165-31tbc31x	46	31	neighboring	neighboring	NN
cord-332165-31tbc31x	46	32	monosaccharides	monosaccharide	NNS
cord-332165-31tbc31x	46	33	.	.	.
cord-332165-31tbc31x	47	1	(	(	-LRB-
cord-332165-31tbc31x	47	2	iii	iii	NN
cord-332165-31tbc31x	47	3	)	)	-RRB-
cord-332165-31tbc31x	48	1	Most	Most	JJS
cord-332165-31tbc31x	48	2	viruses	virus	NNS
cord-332165-31tbc31x	48	3	are	be	VBP
cord-332165-31tbc31x	48	4	highly	highly	RB
cord-332165-31tbc31x	48	5	specific	specific	JJ
cord-332165-31tbc31x	48	6	in	in	IN
cord-332165-31tbc31x	48	7	the	the	DT
cord-332165-31tbc31x	48	8	context	context	NN
cord-332165-31tbc31x	48	9	in	in	IN
cord-332165-31tbc31x	48	10	which	which	WDT
cord-332165-31tbc31x	48	11	sialic	sialic	JJ
cord-332165-31tbc31x	48	12	acid	acid	NN
cord-332165-31tbc31x	48	13	is	be	VBZ
cord-332165-31tbc31x	48	14	presented	present	VBN
cord-332165-31tbc31x	48	15	;	;	:
cord-332165-31tbc31x	48	16	that	that	RB
cord-332165-31tbc31x	48	17	is	is	RB
cord-332165-31tbc31x	48	18	,	,	,
cord-332165-31tbc31x	48	19	they	-PRON-	PRP
cord-332165-31tbc31x	48	20	only	only	RB
cord-332165-31tbc31x	48	21	recognize	recognize	VBP
cord-332165-31tbc31x	48	22	sialylated	sialylated	JJ
cord-332165-31tbc31x	48	23	glycans	glycan	NNS
cord-332165-31tbc31x	48	24	featuring	feature	VBG
cord-332165-31tbc31x	48	25	,	,	,
cord-332165-31tbc31x	48	26	for	for	IN
cord-332165-31tbc31x	48	27	example	example	NN
cord-332165-31tbc31x	48	28	,	,	,
cord-332165-31tbc31x	48	29	α-2,3-linked	α-2,3-linked	JJ
cord-332165-31tbc31x	48	30	sialic	sialic	NN
cord-332165-31tbc31x	48	31	acid	acid	NN
cord-332165-31tbc31x	48	32	but	but	CC
cord-332165-31tbc31x	48	33	do	do	VBP
cord-332165-31tbc31x	48	34	not	not	RB
cord-332165-31tbc31x	48	35	engage	engage	VB
cord-332165-31tbc31x	48	36	sialylated	sialylated	JJ
cord-332165-31tbc31x	48	37	glycans	glycan	NNS
cord-332165-31tbc31x	48	38	carrying	carry	VBG
cord-332165-31tbc31x	48	39	α-2,6-linked	α-2,6-linke	VBN
cord-332165-31tbc31x	48	40	or	or	CC
cord-332165-31tbc31x	48	41	α-2,8-linked	α-2,8-linke	VBN
cord-332165-31tbc31x	48	42	sialic	sialic	NN
cord-332165-31tbc31x	48	43	acid	acid	NN
cord-332165-31tbc31x	48	44	.	.	.
cord-332165-31tbc31x	49	1	(	(	-LRB-
cord-332165-31tbc31x	49	2	iv	iv	LS
cord-332165-31tbc31x	49	3	)	)	-RRB-
cord-332165-31tbc31x	50	1	Although	although	IN
cord-332165-31tbc31x	50	2	the	the	DT
cord-332165-31tbc31x	50	3	database	database	NN
cord-332165-31tbc31x	50	4	remains	remain	VBZ
cord-332165-31tbc31x	50	5	small	small	JJ
cord-332165-31tbc31x	50	6	,	,	,
cord-332165-31tbc31x	50	7	some	some	DT
cord-332165-31tbc31x	50	8	viruses	virus	NNS
cord-332165-31tbc31x	50	9	can	can	MD
cord-332165-31tbc31x	50	10	discriminate	discriminate	VB
cord-332165-31tbc31x	50	11	between	between	IN
cord-332165-31tbc31x	50	12	the	the	DT
cord-332165-31tbc31x	50	13	many	many	JJ
cord-332165-31tbc31x	50	14	different	different	JJ
cord-332165-31tbc31x	50	15	modifications	modification	NNS
cord-332165-31tbc31x	50	16	of	of	IN
cord-332165-31tbc31x	50	17	sialic	sialic	JJ
cord-332165-31tbc31x	50	18	acids	acid	NNS
cord-332165-31tbc31x	50	19	,	,	,
cord-332165-31tbc31x	50	20	and	and	CC
cord-332165-31tbc31x	50	21	,	,	,
cord-332165-31tbc31x	50	22	as	as	IN
cord-332165-31tbc31x	50	23	some	some	DT
cord-332165-31tbc31x	50	24	of	of	IN
cord-332165-31tbc31x	50	25	these	these	DT
cord-332165-31tbc31x	50	26	modifications	modification	NNS
cord-332165-31tbc31x	50	27	,	,	,
cord-332165-31tbc31x	50	28	are	be	VBP
cord-332165-31tbc31x	50	29	species	species	NN
cord-332165-31tbc31x	50	30	-	-	HYPH
cord-332165-31tbc31x	50	31	specific	specific	JJ
cord-332165-31tbc31x	50	32	,	,	,
cord-332165-31tbc31x	50	33	this	this	DT
cord-332165-31tbc31x	50	34	phenomenon	phenomenon	NN
cord-332165-31tbc31x	50	35	can	can	MD
cord-332165-31tbc31x	50	36	contribute	contribute	VB
cord-332165-31tbc31x	50	37	to	to	IN
cord-332165-31tbc31x	50	38	the	the	DT
cord-332165-31tbc31x	50	39	ability	ability	NN
cord-332165-31tbc31x	50	40	of	of	IN
cord-332165-31tbc31x	50	41	a	a	DT
cord-332165-31tbc31x	50	42	virus	virus	NN
cord-332165-31tbc31x	50	43	to	to	TO
cord-332165-31tbc31x	50	44	only	only	RB
cord-332165-31tbc31x	50	45	infect	infect	VB
cord-332165-31tbc31x	50	46	species	specie	NNS
cord-332165-31tbc31x	50	47	that	that	WDT
cord-332165-31tbc31x	50	48	express	express	VBP
cord-332165-31tbc31x	50	49	a	a	DT
cord-332165-31tbc31x	50	50	particular	particular	JJ
cord-332165-31tbc31x	50	51	sialic	sialic	JJ
cord-332165-31tbc31x	50	52	acid	acid	NN
cord-332165-31tbc31x	50	53	modification	modification	NN
cord-332165-31tbc31x	50	54	.	.	.
cord-332165-31tbc31x	51	1	The	the	DT
cord-332165-31tbc31x	51	2	available	available	JJ
cord-332165-31tbc31x	51	3	structural	structural	JJ
cord-332165-31tbc31x	51	4	information	information	NN
cord-332165-31tbc31x	51	5	on	on	IN
cord-332165-31tbc31x	51	6	virus	virus	NN
cord-332165-31tbc31x	51	7	-	-	HYPH
cord-332165-31tbc31x	51	8	receptor	receptor	NN
cord-332165-31tbc31x	51	9	interactions	interaction	NNS
cord-332165-31tbc31x	51	10	is	be	VBZ
cord-332165-31tbc31x	51	11	crucial	crucial	JJ
cord-332165-31tbc31x	51	12	to	to	TO
cord-332165-31tbc31x	51	13	enable	enable	VB
cord-332165-31tbc31x	51	14	the	the	DT
cord-332165-31tbc31x	51	15	rational	rational	JJ
cord-332165-31tbc31x	51	16	design	design	NN
cord-332165-31tbc31x	51	17	of	of	IN
cord-332165-31tbc31x	51	18	therapeutic	therapeutic	JJ
cord-332165-31tbc31x	51	19	compounds	compound	NNS
cord-332165-31tbc31x	51	20	.	.	.
cord-332165-31tbc31x	52	1	Due	due	IN
cord-332165-31tbc31x	52	2	to	to	IN
cord-332165-31tbc31x	52	3	the	the	DT
cord-332165-31tbc31x	52	4	surface	surface	NN
cord-332165-31tbc31x	52	5	-	-	HYPH
cord-332165-31tbc31x	52	6	exposed	expose	VBN
cord-332165-31tbc31x	52	7	binding	binding	NN
cord-332165-31tbc31x	52	8	mode	mode	NN
cord-332165-31tbc31x	52	9	and	and	CC
cord-332165-31tbc31x	52	10	the	the	DT
cord-332165-31tbc31x	52	11	weak	weak	JJ
cord-332165-31tbc31x	52	12	individual	individual	JJ
cord-332165-31tbc31x	52	13	interactions	interaction	NNS
cord-332165-31tbc31x	52	14	between	between	IN
cord-332165-31tbc31x	52	15	sialic	sialic	JJ
cord-332165-31tbc31x	52	16	acids	acid	NNS
cord-332165-31tbc31x	52	17	and	and	CC
cord-332165-31tbc31x	52	18	their	-PRON-	PRP$
cord-332165-31tbc31x	52	19	cognate	cognate	JJ
cord-332165-31tbc31x	52	20	virus	virus	NN
cord-332165-31tbc31x	52	21	proteins	protein	NNS
cord-332165-31tbc31x	52	22	,	,	,
cord-332165-31tbc31x	52	23	modifying	modify	VBG
cord-332165-31tbc31x	52	24	sialic	sialic	JJ
cord-332165-31tbc31x	52	25	acid	acid	NN
cord-332165-31tbc31x	52	26	to	to	TO
cord-332165-31tbc31x	52	27	achieve	achieve	VB
cord-332165-31tbc31x	52	28	high	high	JJ
cord-332165-31tbc31x	52	29	-	-	HYPH
cord-332165-31tbc31x	52	30	affinity	affinity	NN
cord-332165-31tbc31x	52	31	binding	binding	NN
cord-332165-31tbc31x	52	32	is	be	VBZ
cord-332165-31tbc31x	52	33	challenging	challenging	JJ
cord-332165-31tbc31x	52	34	.	.	.
cord-332165-31tbc31x	53	1	However	however	RB
cord-332165-31tbc31x	53	2	,	,	,
cord-332165-31tbc31x	53	3	viruses	virus	NNS
cord-332165-31tbc31x	53	4	possess	possess	VBP
cord-332165-31tbc31x	53	5	many	many	JJ
cord-332165-31tbc31x	53	6	identical	identical	JJ
cord-332165-31tbc31x	53	7	binding	bind	VBG
cord-332165-31tbc31x	53	8	sites	site	NNS
cord-332165-31tbc31x	53	9	that	that	WDT
cord-332165-31tbc31x	53	10	are	be	VBP
cord-332165-31tbc31x	53	11	often	often	RB
cord-332165-31tbc31x	53	12	linked	link	VBN
cord-332165-31tbc31x	53	13	by	by	IN
cord-332165-31tbc31x	53	14	symmetry	symmetry	NN
cord-332165-31tbc31x	53	15	operators	operator	NNS
cord-332165-31tbc31x	53	16	,	,	,
cord-332165-31tbc31x	53	17	and	and	CC
cord-332165-31tbc31x	54	1	thus	thus	RB
cord-332165-31tbc31x	54	2	multivalent	multivalent	JJ
cord-332165-31tbc31x	54	3	and	and	CC
cord-332165-31tbc31x	54	4	symmetric	symmetric	JJ
cord-332165-31tbc31x	54	5	ligands	ligand	NNS
cord-332165-31tbc31x	54	6	that	that	WDT
cord-332165-31tbc31x	54	7	target	target	VBP
cord-332165-31tbc31x	54	8	several	several	JJ
cord-332165-31tbc31x	54	9	binding	bind	VBG
cord-332165-31tbc31x	54	10	sites	site	NNS
cord-332165-31tbc31x	54	11	could	could	MD
cord-332165-31tbc31x	54	12	result	result	VB
cord-332165-31tbc31x	54	13	in	in	IN
cord-332165-31tbc31x	54	14	high	high	JJ
cord-332165-31tbc31x	54	15	-	-	HYPH
cord-332165-31tbc31x	54	16	affinity	affinity	NN
cord-332165-31tbc31x	54	17	interactions	interaction	NNS
cord-332165-31tbc31x	54	18	.	.	.
cord-332165-31tbc31x	55	1	The	the	DT
cord-332165-31tbc31x	55	2	strategy	strategy	NN
cord-332165-31tbc31x	55	3	of	of	IN
cord-332165-31tbc31x	55	4	employing	employ	VBG
cord-332165-31tbc31x	55	5	a	a	DT
cord-332165-31tbc31x	55	6	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	55	7	-	-	HYPH
cord-332165-31tbc31x	55	8	based	base	VBN
cord-332165-31tbc31x	55	9	,	,	,
cord-332165-31tbc31x	55	10	multivalent	multivalent	JJ
cord-332165-31tbc31x	55	11	,	,	,
cord-332165-31tbc31x	55	12	and	and	CC
cord-332165-31tbc31x	55	13	symmetric	symmetric	JJ
cord-332165-31tbc31x	55	14	inhibitor	inhibitor	NN
cord-332165-31tbc31x	55	15	that	that	WDT
cord-332165-31tbc31x	55	16	matches	match	VBZ
cord-332165-31tbc31x	55	17	the	the	DT
cord-332165-31tbc31x	55	18	symmetry	symmetry	NN
cord-332165-31tbc31x	55	19	of	of	IN
cord-332165-31tbc31x	55	20	the	the	DT
cord-332165-31tbc31x	55	21	binding	bind	VBG
cord-332165-31tbc31x	55	22	sites	site	NNS
cord-332165-31tbc31x	55	23	in	in	IN
cord-332165-31tbc31x	55	24	a	a	DT
cord-332165-31tbc31x	55	25	multimeric	multimeric	JJ
cord-332165-31tbc31x	55	26	target	target	NN
cord-332165-31tbc31x	55	27	protein	protein	NN
cord-332165-31tbc31x	55	28	was	be	VBD
cord-332165-31tbc31x	55	29	first	first	RB
cord-332165-31tbc31x	55	30	applied	apply	VBN
cord-332165-31tbc31x	55	31	in	in	IN
cord-332165-31tbc31x	55	32	the	the	DT
cord-332165-31tbc31x	55	33	context	context	NN
cord-332165-31tbc31x	55	34	of	of	IN
cord-332165-31tbc31x	55	35	the	the	DT
cord-332165-31tbc31x	55	36	bacterial	bacterial	JJ
cord-332165-31tbc31x	55	37	Shiga	Shiga	NNP
cord-332165-31tbc31x	55	38	-	-	HYPH
cord-332165-31tbc31x	55	39	like	like	JJ
cord-332165-31tbc31x	55	40	toxin	toxin	NN
cord-332165-31tbc31x	55	41	(	(	-LRB-
cord-332165-31tbc31x	55	42	SLT	SLT	NNP
cord-332165-31tbc31x	55	43	)	)	-RRB-
cord-332165-31tbc31x	55	44	.	.	.
cord-332165-31tbc31x	56	1	SLT	SLT	NNP
cord-332165-31tbc31x	56	2	consists	consist	VBZ
cord-332165-31tbc31x	56	3	of	of	IN
cord-332165-31tbc31x	56	4	an	an	DT
cord-332165-31tbc31x	56	5	enzymatic	enzymatic	JJ
cord-332165-31tbc31x	56	6	domain	domain	NN
cord-332165-31tbc31x	56	7	A	a	NN
cord-332165-31tbc31x	56	8	and	and	CC
cord-332165-31tbc31x	56	9	a	a	DT
cord-332165-31tbc31x	56	10	pentameric	pentameric	NN
cord-332165-31tbc31x	56	11	,	,	,
cord-332165-31tbc31x	56	12	cell	cell	NN
cord-332165-31tbc31x	56	13	-	-	HYPH
cord-332165-31tbc31x	56	14	binding	bind	VBG
cord-332165-31tbc31x	56	15	domain	domain	NN
cord-332165-31tbc31x	56	16	B	B	NNP
cord-332165-31tbc31x	56	17	[	[	-LRB-
cord-332165-31tbc31x	56	18	31	31	CD
cord-332165-31tbc31x	56	19	]	]	-RRB-
cord-332165-31tbc31x	56	20	.	.	.
cord-332165-31tbc31x	57	1	The	the	DT
cord-332165-31tbc31x	57	2	crystal	crystal	NN
cord-332165-31tbc31x	57	3	structures	structure	NNS
cord-332165-31tbc31x	57	4	revealed	reveal	VBD
cord-332165-31tbc31x	57	5	that	that	IN
cord-332165-31tbc31x	57	6	the	the	DT
cord-332165-31tbc31x	57	7	B	B	NNP
cord-332165-31tbc31x	57	8	domain	domain	NN
cord-332165-31tbc31x	57	9	pentamer	pentamer	NNP
cord-332165-31tbc31x	57	10	recognizes	recognize	VBZ
cord-332165-31tbc31x	57	11	the	the	DT
cord-332165-31tbc31x	57	12	p	p	NNP
cord-332165-31tbc31x	57	13	k	k	NNP
cord-332165-31tbc31x	57	14	trisaccharide	trisaccharide	NN
cord-332165-31tbc31x	57	15	portion	portion	NN
cord-332165-31tbc31x	57	16	(	(	-LRB-
cord-332165-31tbc31x	57	17	αGal1	αGal1	NNP
cord-332165-31tbc31x	57	18	-	-	HYPH
cord-332165-31tbc31x	57	19	4βGal1	4βgal1	CD
cord-332165-31tbc31x	57	20	-	-	HYPH
cord-332165-31tbc31x	57	21	4βGlc	4βglc	CD
cord-332165-31tbc31x	57	22	)	)	-RRB-
cord-332165-31tbc31x	57	23	of	of	IN
cord-332165-31tbc31x	57	24	its	-PRON-	PRP$
cord-332165-31tbc31x	57	25	physiologic	physiologic	JJ
cord-332165-31tbc31x	57	26	ganglioside	ganglioside	NN
cord-332165-31tbc31x	57	27	receptor	receptor	NN
cord-332165-31tbc31x	57	28	,	,	,
cord-332165-31tbc31x	57	29	globotriaosylceramide	globotriaosylceramide	NNP
cord-332165-31tbc31x	57	30	(	(	-LRB-
cord-332165-31tbc31x	57	31	Gb	Gb	NNP
cord-332165-31tbc31x	57	32	3	3	CD
cord-332165-31tbc31x	57	33	)	)	-RRB-
cord-332165-31tbc31x	57	34	[	[	-LRB-
cord-332165-31tbc31x	57	35	32	32	CD
cord-332165-31tbc31x	57	36	,	,	,
cord-332165-31tbc31x	57	37	33	33	CD
cord-332165-31tbc31x	57	38	]	]	-RRB-
cord-332165-31tbc31x	57	39	.	.	.
cord-332165-31tbc31x	58	1	In	in	IN
cord-332165-31tbc31x	58	2	order	order	NN
cord-332165-31tbc31x	58	3	to	to	TO
cord-332165-31tbc31x	58	4	achieve	achieve	VB
cord-332165-31tbc31x	58	5	high	high	JJ
cord-332165-31tbc31x	58	6	affinity	affinity	NN
cord-332165-31tbc31x	58	7	binding	binding	NN
cord-332165-31tbc31x	58	8	,	,	,
cord-332165-31tbc31x	58	9	Kitov	Kitov	NNP
cord-332165-31tbc31x	58	10	et	et	NNP
cord-332165-31tbc31x	58	11	al	al	NNP
cord-332165-31tbc31x	58	12	.	.	.
cord-332165-31tbc31x	59	1	[	[	-LRB-
cord-332165-31tbc31x	59	2	34	34	CD
cord-332165-31tbc31x	59	3	]	]	-RRB-
cord-332165-31tbc31x	59	4	designed	design	VBN
cord-332165-31tbc31x	59	5	the	the	DT
cord-332165-31tbc31x	59	6	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	59	7	compound	compound	NN
cord-332165-31tbc31x	59	8	,	,	,
cord-332165-31tbc31x	59	9	a	a	DT
cord-332165-31tbc31x	59	10	quasi	quasi	JJ
cord-332165-31tbc31x	59	11	-	-	JJ
cord-332165-31tbc31x	59	12	symmetric	symmetric	JJ
cord-332165-31tbc31x	59	13	,	,	,
cord-332165-31tbc31x	59	14	pentavalent	pentavalent	JJ
cord-332165-31tbc31x	59	15	molecule	molecule	NN
cord-332165-31tbc31x	59	16	with	with	IN
cord-332165-31tbc31x	59	17	a	a	DT
cord-332165-31tbc31x	59	18	central	central	JJ
cord-332165-31tbc31x	59	19	glucose	glucose	NN
cord-332165-31tbc31x	59	20	motive	motive	NN
cord-332165-31tbc31x	59	21	carrying	carry	VBG
cord-332165-31tbc31x	59	22	five	five	CD
cord-332165-31tbc31x	59	23	linkers	linker	NNS
cord-332165-31tbc31x	59	24	that	that	WDT
cord-332165-31tbc31x	59	25	terminate	terminate	VBP
cord-332165-31tbc31x	59	26	in	in	IN
cord-332165-31tbc31x	59	27	dimeric	dimeric	JJ
cord-332165-31tbc31x	59	28	p	p	NN
cord-332165-31tbc31x	59	29	k	k	NN
cord-332165-31tbc31x	59	30	trisaccharides	trisaccharides	NNP
cord-332165-31tbc31x	59	31	(	(	-LRB-
cord-332165-31tbc31x	59	32	Figure	figure	NN
cord-332165-31tbc31x	59	33	2	2	CD
cord-332165-31tbc31x	59	34	)	)	-RRB-
cord-332165-31tbc31x	59	35	.	.	.
cord-332165-31tbc31x	60	1	X	x	NN
cord-332165-31tbc31x	60	2	-	-	NN
cord-332165-31tbc31x	60	3	ray	ray	JJ
cord-332165-31tbc31x	60	4	crystallography	crystallography	NN
cord-332165-31tbc31x	60	5	of	of	IN
cord-332165-31tbc31x	60	6	the	the	DT
cord-332165-31tbc31x	60	7	toxin	toxin	NN
cord-332165-31tbc31x	60	8	-	-	HYPH
cord-332165-31tbc31x	60	9	inhibitor	inhibitor	NN
cord-332165-31tbc31x	60	10	complex	complex	NN
cord-332165-31tbc31x	60	11	revealed	reveal	VBD
cord-332165-31tbc31x	60	12	a	a	DT
cord-332165-31tbc31x	60	13	sandwich	sandwich	NN
cord-332165-31tbc31x	60	14	-	-	HYPH
cord-332165-31tbc31x	60	15	like	like	JJ
cord-332165-31tbc31x	60	16	arrangement	arrangement	NN
cord-332165-31tbc31x	60	17	of	of	IN
cord-332165-31tbc31x	60	18	two	two	CD
cord-332165-31tbc31x	60	19	SLT	SLT	NNP
cord-332165-31tbc31x	60	20	B	B	NNP
cord-332165-31tbc31x	60	21	-	-	HYPH
cord-332165-31tbc31x	60	22	pentamers	pentamer	NNS
cord-332165-31tbc31x	60	23	intercepted	intercept	VBN
cord-332165-31tbc31x	60	24	by	by	IN
cord-332165-31tbc31x	60	25	one	one	CD
cord-332165-31tbc31x	60	26	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	60	27	molecule	molecule	NN
cord-332165-31tbc31x	60	28	.	.	.
cord-332165-31tbc31x	61	1	All	all	DT
cord-332165-31tbc31x	61	2	five	five	CD
cord-332165-31tbc31x	61	3	B	b	NN
cord-332165-31tbc31x	61	4	-	-	HYPH
cord-332165-31tbc31x	61	5	pentamer	pentamer	NN
cord-332165-31tbc31x	61	6	binding	binding	NN
cord-332165-31tbc31x	61	7	sites	site	NNS
cord-332165-31tbc31x	61	8	were	be	VBD
cord-332165-31tbc31x	61	9	simultaneously	simultaneously	RB
cord-332165-31tbc31x	61	10	occupied	occupy	VBN
cord-332165-31tbc31x	61	11	by	by	IN
cord-332165-31tbc31x	61	12	the	the	DT
cord-332165-31tbc31x	61	13	inhibitor	inhibitor	NN
cord-332165-31tbc31x	61	14	.	.	.
cord-332165-31tbc31x	62	1	In	in	IN
cord-332165-31tbc31x	62	2	line	line	NN
cord-332165-31tbc31x	62	3	with	with	IN
cord-332165-31tbc31x	62	4	this	this	DT
cord-332165-31tbc31x	62	5	,	,	,
cord-332165-31tbc31x	62	6	affinity	affinity	NN
cord-332165-31tbc31x	62	7	measurements	measurement	NNS
cord-332165-31tbc31x	62	8	showed	show	VBD
cord-332165-31tbc31x	62	9	an	an	DT
cord-332165-31tbc31x	62	10	increase	increase	NN
cord-332165-31tbc31x	62	11	in	in	IN
cord-332165-31tbc31x	62	12	the	the	DT
cord-332165-31tbc31x	62	13	inhibition	inhibition	NN
cord-332165-31tbc31x	62	14	potency	potency	NN
cord-332165-31tbc31x	62	15	from	from	IN
cord-332165-31tbc31x	62	16	a	a	DT
cord-332165-31tbc31x	62	17	millimolar	millimolar	JJ
cord-332165-31tbc31x	62	18	affinity	affinity	NN
cord-332165-31tbc31x	62	19	for	for	IN
cord-332165-31tbc31x	62	20	the	the	DT
cord-332165-31tbc31x	62	21	monovalent	monovalent	JJ
cord-332165-31tbc31x	62	22	receptor	receptor	NN
cord-332165-31tbc31x	62	23	(	(	-LRB-
cord-332165-31tbc31x	62	24	p	p	NN
cord-332165-31tbc31x	62	25	k	k	NNP
cord-332165-31tbc31x	62	26	trisaccharide	trisaccharide	NNP
cord-332165-31tbc31x	62	27	)	)	-RRB-
cord-332165-31tbc31x	62	28	to	to	IN
cord-332165-31tbc31x	62	29	a	a	DT
cord-332165-31tbc31x	62	30	subnanomolar	subnanomolar	JJ
cord-332165-31tbc31x	62	31	affinity	affinity	NN
cord-332165-31tbc31x	62	32	for	for	IN
cord-332165-31tbc31x	62	33	the	the	DT
cord-332165-31tbc31x	62	34	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	62	35	compound	compound	NN
cord-332165-31tbc31x	62	36	.	.	.
cord-332165-31tbc31x	63	1	This	this	DT
cord-332165-31tbc31x	63	2	concept	concept	NN
cord-332165-31tbc31x	63	3	of	of	IN
cord-332165-31tbc31x	63	4	targeting	target	VBG
cord-332165-31tbc31x	63	5	multiple	multiple	JJ
cord-332165-31tbc31x	63	6	,	,	,
cord-332165-31tbc31x	63	7	symmetric	symmetric	JJ
cord-332165-31tbc31x	63	8	receptor	receptor	NN
cord-332165-31tbc31x	63	9	binding	bind	VBG
cord-332165-31tbc31x	63	10	sites	site	NNS
cord-332165-31tbc31x	63	11	by	by	IN
cord-332165-31tbc31x	63	12	multivalent	multivalent	JJ
cord-332165-31tbc31x	63	13	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	63	14	is	be	VBZ
cord-332165-31tbc31x	63	15	also	also	RB
cord-332165-31tbc31x	63	16	applicable	applicable	JJ
cord-332165-31tbc31x	63	17	for	for	IN
cord-332165-31tbc31x	63	18	many	many	JJ
cord-332165-31tbc31x	63	19	viruses	virus	NNS
cord-332165-31tbc31x	63	20	,	,	,
cord-332165-31tbc31x	63	21	since	since	IN
cord-332165-31tbc31x	63	22	viral	viral	JJ
cord-332165-31tbc31x	63	23	capsids	capsid	NNS
cord-332165-31tbc31x	63	24	are	be	VBP
cord-332165-31tbc31x	63	25	often	often	RB
cord-332165-31tbc31x	63	26	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	63	27	and	and	CC
cord-332165-31tbc31x	63	28	,	,	,
cord-332165-31tbc31x	63	29	therefore	therefore	RB
cord-332165-31tbc31x	63	30	,	,	,
cord-332165-31tbc31x	63	31	highly	highly	RB
cord-332165-31tbc31x	63	32	symmetric	symmetric	JJ
cord-332165-31tbc31x	63	33	structures	structure	NNS
cord-332165-31tbc31x	63	34	.	.	.
cord-332165-31tbc31x	64	1	Figure	figure	NN
cord-332165-31tbc31x	64	2	2	2	CD
cord-332165-31tbc31x	64	3	.	.	.
cord-332165-31tbc31x	65	1	An	an	DT
cord-332165-31tbc31x	65	2	example	example	NN
cord-332165-31tbc31x	65	3	of	of	IN
cord-332165-31tbc31x	65	4	a	a	DT
cord-332165-31tbc31x	65	5	tailored	tailor	VBN
cord-332165-31tbc31x	65	6	multivalent	multivalent	JJ
cord-332165-31tbc31x	65	7	inhibitor	inhibitor	NN
cord-332165-31tbc31x	65	8	.	.	.
cord-332165-31tbc31x	66	1	The	the	DT
cord-332165-31tbc31x	66	2	globotriaosylceramide	globotriaosylceramide	RB
cord-332165-31tbc31x	66	3	-	-	HYPH
cord-332165-31tbc31x	66	4	binding	bind	VBG
cord-332165-31tbc31x	66	5	B	b	NN
cord-332165-31tbc31x	66	6	-	-	HYPH
cord-332165-31tbc31x	66	7	subunit	subunit	NN
cord-332165-31tbc31x	66	8	of	of	IN
cord-332165-31tbc31x	66	9	Shiga	Shiga	NNP
cord-332165-31tbc31x	66	10	-	-	HYPH
cord-332165-31tbc31x	66	11	like	like	JJ
cord-332165-31tbc31x	66	12	toxin	toxin	NN
cord-332165-31tbc31x	67	1	(	(	-LRB-
cord-332165-31tbc31x	67	2	SLT	SLT	NNP
cord-332165-31tbc31x	67	3	)	)	-RRB-
cord-332165-31tbc31x	67	4	forms	form	VBZ
cord-332165-31tbc31x	67	5	pentamers	pentamer	NNS
cord-332165-31tbc31x	67	6	and	and	CC
cord-332165-31tbc31x	67	7	serves	serve	VBZ
cord-332165-31tbc31x	67	8	as	as	IN
cord-332165-31tbc31x	67	9	target	target	NN
cord-332165-31tbc31x	67	10	for	for	IN
cord-332165-31tbc31x	67	11	the	the	DT
cord-332165-31tbc31x	67	12	pentavalent	pentavalent	JJ
cord-332165-31tbc31x	67	13	inhibitory	inhibitory	JJ
cord-332165-31tbc31x	67	14	compound	compound	NN
cord-332165-31tbc31x	67	15	STARFISH	starfish	NN
cord-332165-31tbc31x	67	16	,	,	,
cord-332165-31tbc31x	67	17	which	which	WDT
cord-332165-31tbc31x	67	18	has	have	VBZ
cord-332165-31tbc31x	67	19	been	be	VBN
cord-332165-31tbc31x	67	20	functionalized	functionalize	VBN
cord-332165-31tbc31x	67	21	with	with	IN
cord-332165-31tbc31x	67	22	the	the	DT
cord-332165-31tbc31x	67	23	p	p	NN
cord-332165-31tbc31x	67	24	k	k	NNP
cord-332165-31tbc31x	67	25	trisaccharide	trisaccharide	NNP
cord-332165-31tbc31x	67	26	.	.	.
cord-332165-31tbc31x	68	1	The	the	DT
cord-332165-31tbc31x	68	2	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	68	3	compound	compound	NN
cord-332165-31tbc31x	68	4	exploits	exploit	VBZ
cord-332165-31tbc31x	68	5	the	the	DT
cord-332165-31tbc31x	68	6	symmetric	symmetric	JJ
cord-332165-31tbc31x	68	7	structure	structure	NN
cord-332165-31tbc31x	68	8	of	of	IN
cord-332165-31tbc31x	68	9	its	-PRON-	PRP$
cord-332165-31tbc31x	68	10	target	target	NN
cord-332165-31tbc31x	68	11	and	and	CC
cord-332165-31tbc31x	68	12	binds	bind	VBZ
cord-332165-31tbc31x	68	13	to	to	IN
cord-332165-31tbc31x	68	14	SLT	SLT	NNP
cord-332165-31tbc31x	68	15	with	with	IN
cord-332165-31tbc31x	68	16	a	a	DT
cord-332165-31tbc31x	68	17	subnanomolar	subnanomolar	JJ
cord-332165-31tbc31x	68	18	affinity	affinity	NN
cord-332165-31tbc31x	68	19	[	[	-LRB-
cord-332165-31tbc31x	68	20	34	34	CD
cord-332165-31tbc31x	68	21	]	]	-RRB-
cord-332165-31tbc31x	68	22	.	.	.
cord-332165-31tbc31x	69	1	The	the	DT
cord-332165-31tbc31x	69	2	SLT	SLT	NNP
cord-332165-31tbc31x	69	3	pentamer	pentamer	NN
cord-332165-31tbc31x	69	4	is	be	VBZ
cord-332165-31tbc31x	69	5	shown	show	VBN
cord-332165-31tbc31x	69	6	as	as	IN
cord-332165-31tbc31x	69	7	a	a	DT
cord-332165-31tbc31x	69	8	protein	protein	NN
cord-332165-31tbc31x	69	9	surface	surface	NN
cord-332165-31tbc31x	69	10	with	with	IN
cord-332165-31tbc31x	69	11	single	single	JJ
cord-332165-31tbc31x	69	12	protomers	protomer	NNS
cord-332165-31tbc31x	69	13	colored	color	VBN
cord-332165-31tbc31x	69	14	in	in	IN
cord-332165-31tbc31x	69	15	grey	grey	JJ
cord-332165-31tbc31x	69	16	,	,	,
cord-332165-31tbc31x	69	17	yellow	yellow	JJ
cord-332165-31tbc31x	69	18	,	,	,
cord-332165-31tbc31x	69	19	pink	pink	JJ
cord-332165-31tbc31x	69	20	,	,	,
cord-332165-31tbc31x	69	21	green	green	JJ
cord-332165-31tbc31x	69	22	,	,	,
cord-332165-31tbc31x	69	23	and	and	CC
cord-332165-31tbc31x	69	24	light	light	JJ
cord-332165-31tbc31x	69	25	blue	blue	NN
cord-332165-31tbc31x	69	26	,	,	,
cord-332165-31tbc31x	69	27	respectively	respectively	RB
cord-332165-31tbc31x	69	28	.	.	.
cord-332165-31tbc31x	70	1	The	the	DT
cord-332165-31tbc31x	70	2	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	70	3	compound	compound	NN
cord-332165-31tbc31x	70	4	is	be	VBZ
cord-332165-31tbc31x	70	5	shown	show	VBN
cord-332165-31tbc31x	70	6	in	in	IN
cord-332165-31tbc31x	70	7	stick	stick	NN
cord-332165-31tbc31x	70	8	representation	representation	NN
cord-332165-31tbc31x	70	9	with	with	IN
cord-332165-31tbc31x	70	10	carbon	carbon	NN
cord-332165-31tbc31x	70	11	,	,	,
cord-332165-31tbc31x	70	12	nitrogen	nitrogen	NN
cord-332165-31tbc31x	70	13	and	and	CC
cord-332165-31tbc31x	70	14	oxygen	oxygen	NN
cord-332165-31tbc31x	70	15	atoms	atom	NNS
cord-332165-31tbc31x	70	16	colored	color	VBN
cord-332165-31tbc31x	70	17	in	in	IN
cord-332165-31tbc31x	70	18	orange	orange	JJ
cord-332165-31tbc31x	70	19	,	,	,
cord-332165-31tbc31x	70	20	dark	dark	JJ
cord-332165-31tbc31x	70	21	blue	blue	JJ
cord-332165-31tbc31x	70	22	and	and	CC
cord-332165-31tbc31x	70	23	red	red	JJ
cord-332165-31tbc31x	70	24	,	,	,
cord-332165-31tbc31x	70	25	respectively	respectively	RB
cord-332165-31tbc31x	70	26	.	.	.
cord-332165-31tbc31x	71	1	Missing	miss	VBG
cord-332165-31tbc31x	71	2	parts	part	NNS
cord-332165-31tbc31x	71	3	of	of	IN
cord-332165-31tbc31x	71	4	the	the	DT
cord-332165-31tbc31x	71	5	scaffold	scaffold	NN
cord-332165-31tbc31x	71	6	structure	structure	NN
cord-332165-31tbc31x	71	7	are	be	VBP
cord-332165-31tbc31x	71	8	schematically	schematically	RB
cord-332165-31tbc31x	71	9	indicated	indicate	VBN
cord-332165-31tbc31x	71	10	as	as	IN
cord-332165-31tbc31x	71	11	orange	orange	JJ
cord-332165-31tbc31x	71	12	lines	line	NNS
cord-332165-31tbc31x	71	13	(	(	-LRB-
cord-332165-31tbc31x	71	14	PDB	PDB	NNP
cord-332165-31tbc31x	71	15	ID	ID	NNP
cord-332165-31tbc31x	71	16	1qnu	1qnu	CD
cord-332165-31tbc31x	71	17	)	)	-RRB-
cord-332165-31tbc31x	71	18	.	.	.
cord-332165-31tbc31x	72	1	All	all	DT
cord-332165-31tbc31x	72	2	protein	protein	NN
cord-332165-31tbc31x	72	3	representations	representation	NNS
cord-332165-31tbc31x	72	4	in	in	IN
cord-332165-31tbc31x	72	5	the	the	DT
cord-332165-31tbc31x	72	6	figures	figure	NNS
cord-332165-31tbc31x	72	7	of	of	IN
cord-332165-31tbc31x	72	8	this	this	DT
cord-332165-31tbc31x	72	9	review	review	NN
cord-332165-31tbc31x	72	10	were	be	VBD
cord-332165-31tbc31x	72	11	generated	generate	VBN
cord-332165-31tbc31x	72	12	using	use	VBG
cord-332165-31tbc31x	72	13	PyMOL	PyMOL	NNP
cord-332165-31tbc31x	73	1	(	(	-LRB-
cord-332165-31tbc31x	73	2	Schrödinger	Schrödinger	NNP
cord-332165-31tbc31x	73	3	Inc.	Inc.	NNP
cord-332165-31tbc31x	73	4	)	)	-RRB-
cord-332165-31tbc31x	73	5	.	.	.
cord-332165-31tbc31x	74	1	In	in	IN
cord-332165-31tbc31x	74	2	this	this	DT
cord-332165-31tbc31x	74	3	chapter	chapter	NN
cord-332165-31tbc31x	74	4	,	,	,
cord-332165-31tbc31x	74	5	we	-PRON-	PRP
cord-332165-31tbc31x	74	6	will	will	MD
cord-332165-31tbc31x	74	7	introduce	introduce	VB
cord-332165-31tbc31x	74	8	some	some	DT
cord-332165-31tbc31x	74	9	universal	universal	JJ
cord-332165-31tbc31x	74	10	concepts	concept	NNS
cord-332165-31tbc31x	74	11	of	of	IN
cord-332165-31tbc31x	74	12	virus	virus	NN
cord-332165-31tbc31x	74	13	capsid	capsid	NN
cord-332165-31tbc31x	74	14	geometry	geometry	NN
cord-332165-31tbc31x	74	15	and	and	CC
cord-332165-31tbc31x	74	16	architecture	architecture	NN
cord-332165-31tbc31x	74	17	,	,	,
cord-332165-31tbc31x	74	18	focusing	focus	VBG
cord-332165-31tbc31x	74	19	in	in	IN
cord-332165-31tbc31x	74	20	particular	particular	JJ
cord-332165-31tbc31x	74	21	on	on	IN
cord-332165-31tbc31x	74	22	non	non	JJ
cord-332165-31tbc31x	74	23	-	-	JJ
cord-332165-31tbc31x	74	24	enveloped	enveloped	JJ
cord-332165-31tbc31x	74	25	viruses	virus	NNS
cord-332165-31tbc31x	74	26	that	that	WDT
cord-332165-31tbc31x	74	27	bind	bind	VBP
cord-332165-31tbc31x	74	28	sialic	sialic	NN
cord-332165-31tbc31x	74	29	acid	acid	NN
cord-332165-31tbc31x	74	30	-	-	HYPH
cord-332165-31tbc31x	74	31	based	base	VBN
cord-332165-31tbc31x	74	32	receptors	receptor	NNS
cord-332165-31tbc31x	74	33	.	.	.
cord-332165-31tbc31x	75	1	We	-PRON-	PRP
cord-332165-31tbc31x	75	2	will	will	MD
cord-332165-31tbc31x	75	3	highlight	highlight	VB
cord-332165-31tbc31x	75	4	the	the	DT
cord-332165-31tbc31x	75	5	local	local	JJ
cord-332165-31tbc31x	75	6	symmetries	symmetry	NNS
cord-332165-31tbc31x	75	7	that	that	WDT
cord-332165-31tbc31x	75	8	relate	relate	VBP
cord-332165-31tbc31x	75	9	the	the	DT
cord-332165-31tbc31x	75	10	sialic	sialic	JJ
cord-332165-31tbc31x	75	11	acid	acid	NN
cord-332165-31tbc31x	75	12	binding	bind	VBG
cord-332165-31tbc31x	75	13	sites	site	NNS
cord-332165-31tbc31x	75	14	in	in	IN
cord-332165-31tbc31x	75	15	different	different	JJ
cord-332165-31tbc31x	75	16	viral	viral	JJ
cord-332165-31tbc31x	75	17	attachment	attachment	NN
cord-332165-31tbc31x	75	18	proteins	protein	NNS
cord-332165-31tbc31x	75	19	to	to	IN
cord-332165-31tbc31x	75	20	each	each	DT
cord-332165-31tbc31x	75	21	other	other	JJ
cord-332165-31tbc31x	75	22	.	.	.
cord-332165-31tbc31x	76	1	These	these	DT
cord-332165-31tbc31x	76	2	local	local	JJ
cord-332165-31tbc31x	76	3	symmetries	symmetry	NNS
cord-332165-31tbc31x	76	4	can	can	MD
cord-332165-31tbc31x	76	5	serve	serve	VB
cord-332165-31tbc31x	76	6	as	as	IN
cord-332165-31tbc31x	76	7	a	a	DT
cord-332165-31tbc31x	76	8	useful	useful	JJ
cord-332165-31tbc31x	76	9	framework	framework	NN
cord-332165-31tbc31x	76	10	for	for	IN
cord-332165-31tbc31x	76	11	the	the	DT
cord-332165-31tbc31x	76	12	rational	rational	JJ
cord-332165-31tbc31x	76	13	design	design	NN
cord-332165-31tbc31x	76	14	of	of	IN
cord-332165-31tbc31x	76	15	multivalent	multivalent	JJ
cord-332165-31tbc31x	76	16	virus	virus	NN
cord-332165-31tbc31x	76	17	-	-	HYPH
cord-332165-31tbc31x	76	18	targeting	target	VBG
cord-332165-31tbc31x	76	19	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	76	20	,	,	,
cord-332165-31tbc31x	76	21	similar	similar	JJ
cord-332165-31tbc31x	76	22	to	to	IN
cord-332165-31tbc31x	76	23	the	the	DT
cord-332165-31tbc31x	76	24	approach	approach	NN
cord-332165-31tbc31x	76	25	used	use	VBN
cord-332165-31tbc31x	76	26	to	to	TO
cord-332165-31tbc31x	76	27	develop	develop	VB
cord-332165-31tbc31x	76	28	the	the	DT
cord-332165-31tbc31x	76	29	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	76	30	compound	compound	NN
cord-332165-31tbc31x	76	31	.	.	.
cord-332165-31tbc31x	77	1	This	this	DT
cord-332165-31tbc31x	77	2	strategy	strategy	NN
cord-332165-31tbc31x	77	3	has	have	VBZ
cord-332165-31tbc31x	77	4	been	be	VBN
cord-332165-31tbc31x	77	5	successfully	successfully	RB
cord-332165-31tbc31x	77	6	applied	apply	VBN
cord-332165-31tbc31x	77	7	to	to	IN
cord-332165-31tbc31x	77	8	several	several	JJ
cord-332165-31tbc31x	77	9	viruses	virus	NNS
cord-332165-31tbc31x	77	10	,	,	,
cord-332165-31tbc31x	77	11	as	as	IN
cord-332165-31tbc31x	77	12	we	-PRON-	PRP
cord-332165-31tbc31x	77	13	will	will	MD
cord-332165-31tbc31x	77	14	show	show	VB
cord-332165-31tbc31x	77	15	in	in	IN
cord-332165-31tbc31x	77	16	chapter	chapter	NN
cord-332165-31tbc31x	77	17	3	3	CD
cord-332165-31tbc31x	77	18	.	.	.
cord-332165-31tbc31x	78	1	However	however	RB
cord-332165-31tbc31x	78	2	,	,	,
cord-332165-31tbc31x	78	3	in	in	IN
cord-332165-31tbc31x	78	4	order	order	NN
cord-332165-31tbc31x	78	5	to	to	TO
cord-332165-31tbc31x	78	6	evaluate	evaluate	VB
cord-332165-31tbc31x	78	7	this	this	DT
cord-332165-31tbc31x	78	8	approach	approach	NN
cord-332165-31tbc31x	78	9	,	,	,
cord-332165-31tbc31x	78	10	we	-PRON-	PRP
cord-332165-31tbc31x	78	11	first	first	RB
cord-332165-31tbc31x	78	12	need	need	VBP
cord-332165-31tbc31x	78	13	to	to	TO
cord-332165-31tbc31x	78	14	introduce	introduce	VB
cord-332165-31tbc31x	78	15	the	the	DT
cord-332165-31tbc31x	78	16	symmetry	symmetry	NN
cord-332165-31tbc31x	78	17	elements	element	NNS
cord-332165-31tbc31x	78	18	that	that	WDT
cord-332165-31tbc31x	78	19	guide	guide	VBP
cord-332165-31tbc31x	78	20	viral	viral	JJ
cord-332165-31tbc31x	78	21	capsid	capsid	NN
cord-332165-31tbc31x	78	22	assembly	assembly	NN
cord-332165-31tbc31x	78	23	.	.	.
cord-332165-31tbc31x	79	1	Typically	typically	RB
cord-332165-31tbc31x	79	2	,	,	,
cord-332165-31tbc31x	79	3	small	small	JJ
cord-332165-31tbc31x	79	4	viral	viral	JJ
cord-332165-31tbc31x	79	5	genomes	genome	NNS
cord-332165-31tbc31x	79	6	can	can	MD
cord-332165-31tbc31x	79	7	only	only	RB
cord-332165-31tbc31x	79	8	encode	encode	VB
cord-332165-31tbc31x	79	9	a	a	DT
cord-332165-31tbc31x	79	10	low	low	JJ
cord-332165-31tbc31x	79	11	number	number	NN
cord-332165-31tbc31x	79	12	of	of	IN
cord-332165-31tbc31x	79	13	structural	structural	JJ
cord-332165-31tbc31x	79	14	capsid	capsid	NN
cord-332165-31tbc31x	79	15	proteins	protein	NNS
cord-332165-31tbc31x	79	16	.	.	.
cord-332165-31tbc31x	80	1	These	these	DT
cord-332165-31tbc31x	80	2	capsid	capsid	NN
cord-332165-31tbc31x	80	3	proteins	protein	NNS
cord-332165-31tbc31x	80	4	often	often	RB
cord-332165-31tbc31x	80	5	form	form	VBP
cord-332165-31tbc31x	80	6	multimers	multimer	NNS
cord-332165-31tbc31x	80	7	(	(	-LRB-
cord-332165-31tbc31x	80	8	capsomers	capsomers	NNP
cord-332165-31tbc31x	80	9	)	)	-RRB-
cord-332165-31tbc31x	80	10	,	,	,
cord-332165-31tbc31x	80	11	which	which	WDT
cord-332165-31tbc31x	80	12	,	,	,
cord-332165-31tbc31x	80	13	again	again	RB
cord-332165-31tbc31x	80	14	,	,	,
cord-332165-31tbc31x	80	15	assemble	assemble	VB
cord-332165-31tbc31x	80	16	into	into	IN
cord-332165-31tbc31x	80	17	a	a	DT
cord-332165-31tbc31x	80	18	stable	stable	JJ
cord-332165-31tbc31x	80	19	virus	virus	NN
cord-332165-31tbc31x	80	20	capsid	capsid	NN
cord-332165-31tbc31x	80	21	that	that	WDT
cord-332165-31tbc31x	80	22	can	can	MD
cord-332165-31tbc31x	80	23	house	house	VB
cord-332165-31tbc31x	80	24	the	the	DT
cord-332165-31tbc31x	80	25	viral	viral	JJ
cord-332165-31tbc31x	80	26	genome	genome	NN
cord-332165-31tbc31x	80	27	and	and	CC
cord-332165-31tbc31x	80	28	associated	associate	VBN
cord-332165-31tbc31x	80	29	components	component	NNS
cord-332165-31tbc31x	80	30	(	(	-LRB-
cord-332165-31tbc31x	80	31	e.g.	e.g.	RB
cord-332165-31tbc31x	80	32	,	,	,
cord-332165-31tbc31x	80	33	nucleoproteins	nucleoprotein	NNS
cord-332165-31tbc31x	80	34	or	or	CC
cord-332165-31tbc31x	80	35	enzymes	enzyme	NNS
cord-332165-31tbc31x	80	36	)	)	-RRB-
cord-332165-31tbc31x	80	37	.	.	.
cord-332165-31tbc31x	81	1	Thus	thus	RB
cord-332165-31tbc31x	81	2	,	,	,
cord-332165-31tbc31x	81	3	the	the	DT
cord-332165-31tbc31x	81	4	assembled	assemble	VBN
cord-332165-31tbc31x	81	5	virus	virus	NN
cord-332165-31tbc31x	81	6	particles	particle	NNS
cord-332165-31tbc31x	81	7	comprise	comprise	VBP
cord-332165-31tbc31x	81	8	many	many	JJ
cord-332165-31tbc31x	81	9	copies	copy	NNS
cord-332165-31tbc31x	81	10	of	of	IN
cord-332165-31tbc31x	81	11	capsid	capsid	NN
cord-332165-31tbc31x	81	12	proteins	protein	NNS
cord-332165-31tbc31x	81	13	and	and	CC
cord-332165-31tbc31x	81	14	display	display	VBP
cord-332165-31tbc31x	81	15	a	a	DT
cord-332165-31tbc31x	81	16	high	high	JJ
cord-332165-31tbc31x	81	17	(	(	-LRB-
cord-332165-31tbc31x	81	18	quasi-	quasi-	NN
cord-332165-31tbc31x	81	19	)	)	-RRB-
cord-332165-31tbc31x	81	20	symmetry	symmetry	NN
cord-332165-31tbc31x	81	21	that	that	WDT
cord-332165-31tbc31x	81	22	is	be	VBZ
cord-332165-31tbc31x	81	23	often	often	RB
cord-332165-31tbc31x	81	24	based	base	VBN
cord-332165-31tbc31x	81	25	on	on	IN
cord-332165-31tbc31x	81	26	an	an	DT
cord-332165-31tbc31x	81	27	icosahedron	icosahedron	NN
cord-332165-31tbc31x	81	28	[	[	-LRB-
cord-332165-31tbc31x	81	29	35	35	CD
cord-332165-31tbc31x	81	30	]	]	-RRB-
cord-332165-31tbc31x	81	31	.	.	.
cord-332165-31tbc31x	82	1	In	in	IN
cord-332165-31tbc31x	82	2	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	82	3	capsids	capsid	NNS
cord-332165-31tbc31x	82	4	,	,	,
cord-332165-31tbc31x	82	5	the	the	DT
cord-332165-31tbc31x	82	6	particle	particle	NN
cord-332165-31tbc31x	82	7	architecture	architecture	NN
cord-332165-31tbc31x	82	8	can	can	MD
cord-332165-31tbc31x	82	9	be	be	VB
cord-332165-31tbc31x	82	10	expressed	express	VBN
cord-332165-31tbc31x	82	11	in	in	IN
cord-332165-31tbc31x	82	12	terms	term	NNS
cord-332165-31tbc31x	82	13	of	of	IN
cord-332165-31tbc31x	82	14	the	the	DT
cord-332165-31tbc31x	82	15	triangulation	triangulation	NN
cord-332165-31tbc31x	82	16	number	number	NN
cord-332165-31tbc31x	82	17	.	.	.
cord-332165-31tbc31x	83	1	An	an	DT
cord-332165-31tbc31x	83	2	icosahedron	icosahedron	NN
cord-332165-31tbc31x	83	3	is	be	VBZ
cord-332165-31tbc31x	83	4	a	a	DT
cord-332165-31tbc31x	83	5	polyhedron	polyhedron	NN
cord-332165-31tbc31x	83	6	consisting	consist	VBG
cord-332165-31tbc31x	83	7	of	of	IN
cord-332165-31tbc31x	83	8	20	20	CD
cord-332165-31tbc31x	83	9	identical	identical	JJ
cord-332165-31tbc31x	83	10	triangular	triangular	JJ
cord-332165-31tbc31x	83	11	faces	face	NNS
cord-332165-31tbc31x	83	12	that	that	WDT
cord-332165-31tbc31x	83	13	intersect	intersect	VBP
cord-332165-31tbc31x	83	14	at	at	IN
cord-332165-31tbc31x	83	15	twelve	twelve	CD
cord-332165-31tbc31x	83	16	vertices	vertex	NNS
cord-332165-31tbc31x	83	17	with	with	IN
cord-332165-31tbc31x	83	18	five	five	CD
cord-332165-31tbc31x	83	19	-	-	HYPH
cord-332165-31tbc31x	83	20	fold	fold	JJ
cord-332165-31tbc31x	83	21	rotational	rotational	JJ
cord-332165-31tbc31x	83	22	symmetry	symmetry	NN
cord-332165-31tbc31x	83	23	.	.	.
cord-332165-31tbc31x	84	1	Three	three	CD
cord-332165-31tbc31x	84	2	-	-	HYPH
cord-332165-31tbc31x	84	3	fold	fold	JJ
cord-332165-31tbc31x	84	4	rotational	rotational	JJ
cord-332165-31tbc31x	84	5	axes	axis	NNS
cord-332165-31tbc31x	84	6	are	be	VBP
cord-332165-31tbc31x	84	7	located	locate	VBN
cord-332165-31tbc31x	84	8	in	in	IN
cord-332165-31tbc31x	84	9	the	the	DT
cord-332165-31tbc31x	84	10	center	center	NN
cord-332165-31tbc31x	84	11	of	of	IN
cord-332165-31tbc31x	84	12	each	each	DT
cord-332165-31tbc31x	84	13	triangular	triangular	JJ
cord-332165-31tbc31x	84	14	face	face	NN
cord-332165-31tbc31x	84	15	.	.	.
cord-332165-31tbc31x	85	1	The	the	DT
cord-332165-31tbc31x	85	2	edges	edge	NNS
cord-332165-31tbc31x	85	3	between	between	IN
cord-332165-31tbc31x	85	4	the	the	DT
cord-332165-31tbc31x	85	5	faces	face	NNS
cord-332165-31tbc31x	85	6	are	be	VBP
cord-332165-31tbc31x	85	7	intersected	intersect	VBN
cord-332165-31tbc31x	85	8	by	by	IN
cord-332165-31tbc31x	85	9	two	two	CD
cord-332165-31tbc31x	85	10	-	-	HYPH
cord-332165-31tbc31x	85	11	fold	fold	JJ
cord-332165-31tbc31x	85	12	rotational	rotational	JJ
cord-332165-31tbc31x	85	13	axes	axis	NNS
cord-332165-31tbc31x	85	14	.	.	.
cord-332165-31tbc31x	86	1	The	the	DT
cord-332165-31tbc31x	86	2	combination	combination	NN
cord-332165-31tbc31x	86	3	of	of	IN
cord-332165-31tbc31x	86	4	these	these	DT
cord-332165-31tbc31x	86	5	symmetry	symmetry	NN
cord-332165-31tbc31x	86	6	operations	operation	NNS
cord-332165-31tbc31x	86	7	gives	give	VBZ
cord-332165-31tbc31x	86	8	rise	rise	NN
cord-332165-31tbc31x	86	9	to	to	IN
cord-332165-31tbc31x	86	10	the	the	DT
cord-332165-31tbc31x	86	11	532	532	CD
cord-332165-31tbc31x	86	12	point	point	NN
cord-332165-31tbc31x	86	13	group	group	NN
cord-332165-31tbc31x	86	14	of	of	IN
cord-332165-31tbc31x	86	15	an	an	DT
cord-332165-31tbc31x	86	16	icosahedron	icosahedron	NN
cord-332165-31tbc31x	86	17	(	(	-LRB-
cord-332165-31tbc31x	86	18	Figure	figure	NN
cord-332165-31tbc31x	86	19	3	3	CD
cord-332165-31tbc31x	86	20	,	,	,
cord-332165-31tbc31x	86	21	lower	low	JJR
cord-332165-31tbc31x	86	22	right	right	NN
cord-332165-31tbc31x	86	23	)	)	-RRB-
cord-332165-31tbc31x	86	24	.	.	.
cord-332165-31tbc31x	87	1	In	in	IN
cord-332165-31tbc31x	87	2	the	the	DT
cord-332165-31tbc31x	87	3	context	context	NN
cord-332165-31tbc31x	87	4	of	of	IN
cord-332165-31tbc31x	87	5	an	an	DT
cord-332165-31tbc31x	87	6	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	87	7	virus	virus	NN
cord-332165-31tbc31x	87	8	particle	particle	NN
cord-332165-31tbc31x	87	9	,	,	,
cord-332165-31tbc31x	87	10	the	the	DT
cord-332165-31tbc31x	87	11	triangulation	triangulation	NN
cord-332165-31tbc31x	87	12	number	number	NN
cord-332165-31tbc31x	87	13	(	(	-LRB-
cord-332165-31tbc31x	87	14	T	t	NN
cord-332165-31tbc31x	87	15	=	=	SYM
cord-332165-31tbc31x	87	16	h	h	NN
cord-332165-31tbc31x	87	17	2	2	CD
cord-332165-31tbc31x	87	18	+	+	SYM
cord-332165-31tbc31x	87	19	hk	hk	NNP
cord-332165-31tbc31x	87	20	+	+	CC
cord-332165-31tbc31x	87	21	k	k	NNP
cord-332165-31tbc31x	87	22	2	2	CD
cord-332165-31tbc31x	87	23	)	)	-RRB-
cord-332165-31tbc31x	87	24	can	can	MD
cord-332165-31tbc31x	87	25	be	be	VB
cord-332165-31tbc31x	87	26	interpreted	interpret	VBN
cord-332165-31tbc31x	87	27	as	as	IN
cord-332165-31tbc31x	87	28	a	a	DT
cord-332165-31tbc31x	87	29	measure	measure	NN
cord-332165-31tbc31x	87	30	of	of	IN
cord-332165-31tbc31x	87	31	capsid	capsid	NN
cord-332165-31tbc31x	87	32	size	size	NN
cord-332165-31tbc31x	87	33	.	.	.
cord-332165-31tbc31x	88	1	It	-PRON-	PRP
cord-332165-31tbc31x	88	2	is	be	VBZ
cord-332165-31tbc31x	88	3	calculated	calculate	VBN
cord-332165-31tbc31x	88	4	by	by	IN
cord-332165-31tbc31x	88	5	the	the	DT
cord-332165-31tbc31x	88	6	numbers	number	NNS
cord-332165-31tbc31x	88	7	of	of	IN
cord-332165-31tbc31x	88	8	inter	inter	JJ
cord-332165-31tbc31x	88	9	-	-	JJ
cord-332165-31tbc31x	88	10	capsomeric	capsomeric	JJ
cord-332165-31tbc31x	88	11	steps	step	NNS
cord-332165-31tbc31x	88	12	(	(	-LRB-
cord-332165-31tbc31x	88	13	iterated	iterate	VBN
cord-332165-31tbc31x	88	14	in	in	IN
cord-332165-31tbc31x	88	15	h	h	NNP
cord-332165-31tbc31x	88	16	and	and	CC
cord-332165-31tbc31x	88	17	k	k	NNP
cord-332165-31tbc31x	88	18	)	)	-RRB-
cord-332165-31tbc31x	88	19	that	that	IN
cord-332165-31tbc31x	88	20	one	one	NN
cord-332165-31tbc31x	88	21	has	have	VBZ
cord-332165-31tbc31x	88	22	to	to	TO
cord-332165-31tbc31x	88	23	traverse	traverse	VB
cord-332165-31tbc31x	88	24	via	via	IN
cord-332165-31tbc31x	88	25	(	(	-LRB-
cord-332165-31tbc31x	88	26	quasi-	quasi-	NN
cord-332165-31tbc31x	88	27	)	)	-RRB-
cord-332165-31tbc31x	88	28	six	six	CD
cord-332165-31tbc31x	88	29	-	-	HYPH
cord-332165-31tbc31x	88	30	fold	fold	JJ
cord-332165-31tbc31x	88	31	symmetric	symmetric	JJ
cord-332165-31tbc31x	88	32	capsomers	capsomer	NNS
cord-332165-31tbc31x	88	33	,	,	,
cord-332165-31tbc31x	88	34	from	from	IN
cord-332165-31tbc31x	88	35	one	one	CD
cord-332165-31tbc31x	88	36	five	five	CD
cord-332165-31tbc31x	88	37	-	-	HYPH
cord-332165-31tbc31x	88	38	fold	fold	JJ
cord-332165-31tbc31x	88	39	vertex	vertex	NN
cord-332165-31tbc31x	88	40	to	to	IN
cord-332165-31tbc31x	88	41	another	another	DT
cord-332165-31tbc31x	88	42	.	.	.
cord-332165-31tbc31x	89	1	Five	five	CD
cord-332165-31tbc31x	89	2	-	-	JJ
cord-332165-31tbc31x	89	3	fold	fold	JJ
cord-332165-31tbc31x	89	4	vertices	vertex	NNS
cord-332165-31tbc31x	89	5	and	and	CC
cord-332165-31tbc31x	89	6	the	the	DT
cord-332165-31tbc31x	89	7	associated	associate	VBN
cord-332165-31tbc31x	89	8	capsid	capsid	NN
cord-332165-31tbc31x	89	9	proteins	protein	NNS
cord-332165-31tbc31x	89	10	are	be	VBP
cord-332165-31tbc31x	89	11	highlighted	highlight	VBN
cord-332165-31tbc31x	89	12	in	in	IN
cord-332165-31tbc31x	89	13	blue	blue	NN
cord-332165-31tbc31x	89	14	.	.	.
cord-332165-31tbc31x	90	1	A	a	DT
cord-332165-31tbc31x	90	2	schematic	schematic	JJ
cord-332165-31tbc31x	90	3	view	view	NN
cord-332165-31tbc31x	90	4	of	of	IN
cord-332165-31tbc31x	90	5	an	an	DT
cord-332165-31tbc31x	90	6	icosahedron	icosahedron	NN
cord-332165-31tbc31x	90	7	in	in	IN
cord-332165-31tbc31x	90	8	the	the	DT
cord-332165-31tbc31x	90	9	same	same	JJ
cord-332165-31tbc31x	90	10	orientation	orientation	NN
cord-332165-31tbc31x	90	11	is	be	VBZ
cord-332165-31tbc31x	90	12	shown	show	VBN
cord-332165-31tbc31x	90	13	on	on	IN
cord-332165-31tbc31x	90	14	the	the	DT
cord-332165-31tbc31x	90	15	lower	low	JJR
cord-332165-31tbc31x	90	16	right	right	NN
cord-332165-31tbc31x	90	17	,	,	,
cord-332165-31tbc31x	90	18	with	with	IN
cord-332165-31tbc31x	90	19	two	two	CD
cord-332165-31tbc31x	90	20	-	-	RB
cord-332165-31tbc31x	90	21	fold	fold	JJ
cord-332165-31tbc31x	90	22	,	,	,
cord-332165-31tbc31x	90	23	three	three	CD
cord-332165-31tbc31x	90	24	-	-	HYPH
cord-332165-31tbc31x	90	25	fold	fold	NN
cord-332165-31tbc31x	90	26	and	and	CC
cord-332165-31tbc31x	90	27	five	five	CD
cord-332165-31tbc31x	90	28	-	-	HYPH
cord-332165-31tbc31x	90	29	fold	fold	JJ
cord-332165-31tbc31x	90	30	axes	axis	NNS
cord-332165-31tbc31x	90	31	indicated	indicate	VBN
cord-332165-31tbc31x	90	32	as	as	IN
cord-332165-31tbc31x	90	33	ellipse	ellipse	NN
cord-332165-31tbc31x	90	34	,	,	,
cord-332165-31tbc31x	90	35	triangle	triangle	NNP
cord-332165-31tbc31x	90	36	and	and	CC
cord-332165-31tbc31x	90	37	pentagon	pentagon	NNP
cord-332165-31tbc31x	90	38	,	,	,
cord-332165-31tbc31x	90	39	respectively	respectively	RB
cord-332165-31tbc31x	90	40	.	.	.
cord-332165-31tbc31x	91	1	PDB	PDB	NNP
cord-332165-31tbc31x	91	2	IDs	id	NNS
cord-332165-31tbc31x	91	3	6b1	6b1	CD
cord-332165-31tbc31x	91	4	t	t	NN
cord-332165-31tbc31x	91	5	(	(	-LRB-
cord-332165-31tbc31x	91	6	adenovirus	adenovirus	NN
cord-332165-31tbc31x	91	7	)	)	-RRB-
cord-332165-31tbc31x	91	8	,	,	,
cord-332165-31tbc31x	91	9	2cse	2cse	CD
cord-332165-31tbc31x	91	10	(	(	-LRB-
cord-332165-31tbc31x	91	11	orthoreovirus	orthoreovirus	NNP
cord-332165-31tbc31x	91	12	)	)	-RRB-
cord-332165-31tbc31x	91	13	,	,	,
cord-332165-31tbc31x	91	14	3kz4	3kz4	NNP
cord-332165-31tbc31x	91	15	(	(	-LRB-
cord-332165-31tbc31x	91	16	rotavirus	rotavirus	NN
cord-332165-31tbc31x	91	17	)	)	-RRB-
cord-332165-31tbc31x	91	18	,	,	.
cord-332165-31tbc31x	92	1	1sid	1sid	NNP
cord-332165-31tbc31x	92	2	(	(	-LRB-
cord-332165-31tbc31x	92	3	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	92	4	)	)	-RRB-
cord-332165-31tbc31x	92	5	,	,	,
cord-332165-31tbc31x	92	6	and	and	CC
cord-332165-31tbc31x	92	7	4q4w	4q4w	NNP
cord-332165-31tbc31x	92	8	(	(	-LRB-
cord-332165-31tbc31x	92	9	coxsackievirus	coxsackievirus	NNP
cord-332165-31tbc31x	92	10	)	)	-RRB-
cord-332165-31tbc31x	92	11	.	.	.
cord-332165-31tbc31x	93	1	The	the	DT
cord-332165-31tbc31x	93	2	smallest	small	JJS
cord-332165-31tbc31x	93	3	and	and	CC
cord-332165-31tbc31x	93	4	simplest	simplest	JJ
cord-332165-31tbc31x	93	5	virus	virus	NN
cord-332165-31tbc31x	93	6	capsids	capsid	NNS
cord-332165-31tbc31x	93	7	have	have	VBP
cord-332165-31tbc31x	93	8	an	an	DT
cord-332165-31tbc31x	93	9	architecture	architecture	NN
cord-332165-31tbc31x	93	10	corresponding	correspond	VBG
cord-332165-31tbc31x	93	11	to	to	IN
cord-332165-31tbc31x	93	12	a	a	DT
cord-332165-31tbc31x	93	13	triangulation	triangulation	NN
cord-332165-31tbc31x	93	14	number	number	NN
cord-332165-31tbc31x	93	15	of	of	IN
cord-332165-31tbc31x	93	16	T=1	T=1	NNP
cord-332165-31tbc31x	93	17	.	.	.
cord-332165-31tbc31x	94	1	In	in	IN
cord-332165-31tbc31x	94	2	a	a	DT
cord-332165-31tbc31x	94	3	T=1	T=1	NNP
cord-332165-31tbc31x	94	4	capsid	capsid	NN
cord-332165-31tbc31x	94	5	,	,	,
cord-332165-31tbc31x	94	6	each	each	DT
cord-332165-31tbc31x	94	7	of	of	IN
cord-332165-31tbc31x	94	8	the	the	DT
cord-332165-31tbc31x	94	9	twelve	twelve	CD
cord-332165-31tbc31x	94	10	five	five	CD
cord-332165-31tbc31x	94	11	-	-	RB
cord-332165-31tbc31x	94	12	fold	fold	JJ
cord-332165-31tbc31x	94	13	symmetric	symmetric	JJ
cord-332165-31tbc31x	94	14	vertices	vertex	NNS
cord-332165-31tbc31x	94	15	are	be	VBP
cord-332165-31tbc31x	94	16	occupied	occupy	VBN
cord-332165-31tbc31x	94	17	by	by	IN
cord-332165-31tbc31x	94	18	a	a	DT
cord-332165-31tbc31x	94	19	single	single	JJ
cord-332165-31tbc31x	94	20	capsid	capsid	NN
cord-332165-31tbc31x	94	21	protein	protein	NN
cord-332165-31tbc31x	94	22	pentamer	pentamer	NNP
cord-332165-31tbc31x	94	23	.	.	.
cord-332165-31tbc31x	95	1	Neighboring	neighboring	NN
cord-332165-31tbc31x	95	2	capsomers	capsomer	NNS
cord-332165-31tbc31x	95	3	are	be	VBP
cord-332165-31tbc31x	95	4	pentamers	pentamer	NNS
cord-332165-31tbc31x	95	5	that	that	WDT
cord-332165-31tbc31x	95	6	are	be	VBP
cord-332165-31tbc31x	95	7	also	also	RB
cord-332165-31tbc31x	95	8	associated	associate	VBN
cord-332165-31tbc31x	95	9	with	with	IN
cord-332165-31tbc31x	95	10	the	the	DT
cord-332165-31tbc31x	95	11	five	five	CD
cord-332165-31tbc31x	95	12	-	-	JJ
cord-332165-31tbc31x	95	13	fold	fold	JJ
cord-332165-31tbc31x	95	14	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	95	15	vertices	vertex	NNS
cord-332165-31tbc31x	95	16	.	.	.
cord-332165-31tbc31x	96	1	No	no	DT
cord-332165-31tbc31x	96	2	additional	additional	JJ
cord-332165-31tbc31x	96	3	capsomers	capsomer	NNS
cord-332165-31tbc31x	96	4	are	be	VBP
cord-332165-31tbc31x	96	5	present	present	JJ
cord-332165-31tbc31x	96	6	,	,	,
cord-332165-31tbc31x	96	7	which	which	WDT
cord-332165-31tbc31x	96	8	gives	give	VBZ
cord-332165-31tbc31x	96	9	rise	rise	NN
cord-332165-31tbc31x	96	10	to	to	IN
cord-332165-31tbc31x	96	11	a	a	DT
cord-332165-31tbc31x	96	12	total	total	JJ
cord-332165-31tbc31x	96	13	number	number	NN
cord-332165-31tbc31x	96	14	of	of	IN
cord-332165-31tbc31x	96	15	12	12	CD
cord-332165-31tbc31x	96	16	×	×	NN
cord-332165-31tbc31x	96	17	5	5	CD
cord-332165-31tbc31x	96	18	=	=	SYM
cord-332165-31tbc31x	96	19	60	60	CD
cord-332165-31tbc31x	96	20	capsid	capsid	NN
cord-332165-31tbc31x	96	21	proteins	protein	NNS
cord-332165-31tbc31x	96	22	in	in	IN
cord-332165-31tbc31x	96	23	the	the	DT
cord-332165-31tbc31x	96	24	particle	particle	NN
cord-332165-31tbc31x	96	25	.	.	.
cord-332165-31tbc31x	97	1	To	to	IN
cord-332165-31tbc31x	97	2	our	-PRON-	PRP$
cord-332165-31tbc31x	97	3	knowledge	knowledge	NN
cord-332165-31tbc31x	97	4	,	,	,
cord-332165-31tbc31x	97	5	the	the	DT
cord-332165-31tbc31x	97	6	only	only	JJ
cord-332165-31tbc31x	97	7	example	example	NN
cord-332165-31tbc31x	97	8	of	of	IN
cord-332165-31tbc31x	97	9	a	a	DT
cord-332165-31tbc31x	97	10	T=1	T=1	NNP
cord-332165-31tbc31x	97	11	sialic	sialic	NN
cord-332165-31tbc31x	97	12	acid	acid	NN
cord-332165-31tbc31x	97	13	binding	bind	VBG
cord-332165-31tbc31x	97	14	capsid	capsid	NN
cord-332165-31tbc31x	97	15	is	be	VBZ
cord-332165-31tbc31x	97	16	found	find	VBN
cord-332165-31tbc31x	97	17	in	in	IN
cord-332165-31tbc31x	97	18	the	the	DT
cord-332165-31tbc31x	97	19	Adeno	Adeno	NNP
cord-332165-31tbc31x	97	20	-	-	HYPH
cord-332165-31tbc31x	97	21	associated	associate	VBN
cord-332165-31tbc31x	97	22	virus	virus	NN
cord-332165-31tbc31x	97	23	(	(	-LRB-
cord-332165-31tbc31x	97	24	AAV	AAV	NNP
cord-332165-31tbc31x	97	25	)	)	-RRB-
cord-332165-31tbc31x	97	26	of	of	IN
cord-332165-31tbc31x	97	27	the	the	DT
cord-332165-31tbc31x	97	28	Parvoviridae	Parvoviridae	NNP
cord-332165-31tbc31x	97	29	family	family	NN
cord-332165-31tbc31x	97	30	.	.	.
cord-332165-31tbc31x	98	1	Sialic	sialic	NN
cord-332165-31tbc31x	98	2	acid	acid	NN
cord-332165-31tbc31x	98	3	binding	binding	NN
cord-332165-31tbc31x	98	4	in	in	IN
cord-332165-31tbc31x	98	5	AAV	AAV	NNP
cord-332165-31tbc31x	98	6	was	be	VBD
cord-332165-31tbc31x	98	7	reported	report	VBN
cord-332165-31tbc31x	98	8	to	to	TO
cord-332165-31tbc31x	98	9	occur	occur	VB
cord-332165-31tbc31x	98	10	at	at	IN
cord-332165-31tbc31x	98	11	the	the	DT
cord-332165-31tbc31x	98	12	interface	interface	NN
cord-332165-31tbc31x	98	13	between	between	IN
cord-332165-31tbc31x	98	14	two	two	CD
cord-332165-31tbc31x	98	15	single	single	JJ
cord-332165-31tbc31x	98	16	capsid	capsid	NN
cord-332165-31tbc31x	98	17	protein	protein	NN
cord-332165-31tbc31x	98	18	monomer	monomer	NN
cord-332165-31tbc31x	98	19	chains	chain	NNS
cord-332165-31tbc31x	98	20	,	,	,
cord-332165-31tbc31x	98	21	resulting	result	VBG
cord-332165-31tbc31x	98	22	in	in	IN
cord-332165-31tbc31x	98	23	a	a	DT
cord-332165-31tbc31x	98	24	total	total	JJ
cord-332165-31tbc31x	98	25	number	number	NN
cord-332165-31tbc31x	98	26	of	of	IN
cord-332165-31tbc31x	98	27	60	60	CD
cord-332165-31tbc31x	98	28	binding	bind	VBG
cord-332165-31tbc31x	98	29	sites	site	NNS
cord-332165-31tbc31x	98	30	in	in	IN
cord-332165-31tbc31x	98	31	the	the	DT
cord-332165-31tbc31x	98	32	capsid	capsid	NN
cord-332165-31tbc31x	98	33	.	.	.
cord-332165-31tbc31x	99	1	The	the	DT
cord-332165-31tbc31x	99	2	symmetry	symmetry	NN
cord-332165-31tbc31x	99	3	of	of	IN
cord-332165-31tbc31x	99	4	the	the	DT
cord-332165-31tbc31x	99	5	local	local	JJ
cord-332165-31tbc31x	99	6	binding	binding	NN
cord-332165-31tbc31x	99	7	site	site	NN
cord-332165-31tbc31x	99	8	is	be	VBZ
cord-332165-31tbc31x	99	9	defined	define	VBN
cord-332165-31tbc31x	99	10	by	by	IN
cord-332165-31tbc31x	99	11	the	the	DT
cord-332165-31tbc31x	99	12	shortest	short	JJS
cord-332165-31tbc31x	99	13	distance	distance	NN
cord-332165-31tbc31x	99	14	of	of	IN
cord-332165-31tbc31x	99	15	a	a	DT
cord-332165-31tbc31x	99	16	single	single	JJ
cord-332165-31tbc31x	99	17	binding	binding	NN
cord-332165-31tbc31x	99	18	site	site	NN
cord-332165-31tbc31x	99	19	towards	towards	IN
cord-332165-31tbc31x	99	20	the	the	DT
cord-332165-31tbc31x	99	21	rotational	rotational	JJ
cord-332165-31tbc31x	99	22	axis	axis	NN
cord-332165-31tbc31x	99	23	.	.	.
cord-332165-31tbc31x	100	1	The	the	DT
cord-332165-31tbc31x	100	2	AAV	AAV	NNP
cord-332165-31tbc31x	100	3	capsid	capsid	NN
cord-332165-31tbc31x	100	4	proteins	protein	NNS
cord-332165-31tbc31x	100	5	that	that	WDT
cord-332165-31tbc31x	100	6	are	be	VBP
cord-332165-31tbc31x	100	7	responsible	responsible	JJ
cord-332165-31tbc31x	100	8	for	for	IN
cord-332165-31tbc31x	100	9	sialic	sialic	JJ
cord-332165-31tbc31x	100	10	acid	acid	NN
cord-332165-31tbc31x	100	11	binding	bind	VBG
cord-332165-31tbc31x	100	12	form	form	NN
cord-332165-31tbc31x	100	13	pentamers	pentamer	NNS
cord-332165-31tbc31x	100	14	.	.	.
cord-332165-31tbc31x	101	1	However	however	RB
cord-332165-31tbc31x	101	2	,	,	,
cord-332165-31tbc31x	101	3	the	the	DT
cord-332165-31tbc31x	101	4	binding	bind	VBG
cord-332165-31tbc31x	101	5	sites	site	NNS
cord-332165-31tbc31x	101	6	themselves	-PRON-	PRP
cord-332165-31tbc31x	101	7	locate	locate	VBP
cord-332165-31tbc31x	101	8	closer	close	RBR
cord-332165-31tbc31x	101	9	to	to	IN
cord-332165-31tbc31x	101	10	the	the	DT
cord-332165-31tbc31x	101	11	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	101	12	three	three	CD
cord-332165-31tbc31x	101	13	-	-	HYPH
cord-332165-31tbc31x	101	14	fold	fold	NN
cord-332165-31tbc31x	101	15	symmetry	symmetry	NN
cord-332165-31tbc31x	101	16	axis	axis	NN
cord-332165-31tbc31x	101	17	than	than	IN
cord-332165-31tbc31x	101	18	the	the	DT
cord-332165-31tbc31x	101	19	five	five	CD
cord-332165-31tbc31x	101	20	-	-	HYPH
cord-332165-31tbc31x	101	21	fold	fold	JJ
cord-332165-31tbc31x	101	22	capsomer	capsomer	NN
cord-332165-31tbc31x	101	23	/	/	SYM
cord-332165-31tbc31x	101	24	vertex	vertex	NN
cord-332165-31tbc31x	101	25	axis	axis	NN
cord-332165-31tbc31x	101	26	.	.	.
cord-332165-31tbc31x	102	1	This	this	DT
cord-332165-31tbc31x	102	2	implies	imply	VBZ
cord-332165-31tbc31x	102	3	that	that	IN
cord-332165-31tbc31x	102	4	the	the	DT
cord-332165-31tbc31x	102	5	60	60	CD
cord-332165-31tbc31x	102	6	sialic	sialic	NN
cord-332165-31tbc31x	102	7	acid	acid	NN
cord-332165-31tbc31x	102	8	binding	bind	VBG
cord-332165-31tbc31x	102	9	sites	site	NNS
cord-332165-31tbc31x	102	10	of	of	IN
cord-332165-31tbc31x	102	11	the	the	DT
cord-332165-31tbc31x	102	12	AAV	AAV	NNP
cord-332165-31tbc31x	102	13	capsid	capsid	NN
cord-332165-31tbc31x	102	14	are	be	VBP
cord-332165-31tbc31x	102	15	arranged	arrange	VBN
cord-332165-31tbc31x	102	16	in	in	IN
cord-332165-31tbc31x	102	17	twenty	twenty	CD
cord-332165-31tbc31x	102	18	local	local	JJ
cord-332165-31tbc31x	102	19	three	three	CD
cord-332165-31tbc31x	102	20	-	-	:
cord-332165-31tbc31x	102	21	fold	fold	NN
cord-332165-31tbc31x	102	22	rather	rather	RB
cord-332165-31tbc31x	102	23	than	than	IN
cord-332165-31tbc31x	102	24	twelve	twelve	CD
cord-332165-31tbc31x	102	25	local	local	JJ
cord-332165-31tbc31x	102	26	five	five	CD
cord-332165-31tbc31x	102	27	-	-	HYPH
cord-332165-31tbc31x	102	28	fold	fold	JJ
cord-332165-31tbc31x	102	29	symmetries	symmetry	NNS
cord-332165-31tbc31x	102	30	[	[	-LRB-
cord-332165-31tbc31x	102	31	36	36	CD
cord-332165-31tbc31x	102	32	]	]	-RRB-
cord-332165-31tbc31x	102	33	.	.	.
cord-332165-31tbc31x	103	1	Virus	virus	NN
cord-332165-31tbc31x	103	2	particles	particle	NNS
cord-332165-31tbc31x	103	3	comprising	comprise	VBG
cord-332165-31tbc31x	103	4	more	more	JJR
cord-332165-31tbc31x	103	5	than	than	IN
cord-332165-31tbc31x	103	6	twelve	twelve	CD
cord-332165-31tbc31x	103	7	capsomers	capsomer	NNS
cord-332165-31tbc31x	103	8	must	must	MD
cord-332165-31tbc31x	103	9	,	,	,
cord-332165-31tbc31x	103	10	by	by	IN
cord-332165-31tbc31x	103	11	definition	definition	NN
cord-332165-31tbc31x	103	12	,	,	,
cord-332165-31tbc31x	103	13	have	have	VBP
cord-332165-31tbc31x	103	14	a	a	DT
cord-332165-31tbc31x	103	15	higher	high	JJR
cord-332165-31tbc31x	103	16	triangulation	triangulation	NN
cord-332165-31tbc31x	103	17	number	number	NN
cord-332165-31tbc31x	103	18	than	than	IN
cord-332165-31tbc31x	103	19	T=1	T=1	NNP
cord-332165-31tbc31x	103	20	.	.	.
cord-332165-31tbc31x	104	1	Picornaviridae	Picornaviridae	NNP
cord-332165-31tbc31x	104	2	family	family	NN
cord-332165-31tbc31x	104	3	members	member	NNS
cord-332165-31tbc31x	104	4	(	(	-LRB-
cord-332165-31tbc31x	104	5	such	such	JJ
cord-332165-31tbc31x	104	6	as	as	IN
cord-332165-31tbc31x	104	7	coxsackieviruses	coxsackievirus	NNS
cord-332165-31tbc31x	104	8	,	,	,
cord-332165-31tbc31x	104	9	rhinoviruses	rhinovirus	NNS
cord-332165-31tbc31x	104	10	,	,	,
cord-332165-31tbc31x	104	11	polioviruses	poliovirus	NNS
cord-332165-31tbc31x	104	12	,	,	,
cord-332165-31tbc31x	104	13	or	or	CC
cord-332165-31tbc31x	104	14	enteroviruses	enteroviruses	NNP
cord-332165-31tbc31x	104	15	)	)	-RRB-
cord-332165-31tbc31x	104	16	are	be	VBP
cord-332165-31tbc31x	104	17	viruses	virus	NNS
cord-332165-31tbc31x	104	18	possessing	possess	VBG
cord-332165-31tbc31x	104	19	three	three	CD
cord-332165-31tbc31x	104	20	surface	surface	NN
cord-332165-31tbc31x	104	21	-	-	HYPH
cord-332165-31tbc31x	104	22	exposed	expose	VBN
cord-332165-31tbc31x	104	23	capsid	capsid	NN
cord-332165-31tbc31x	104	24	proteins	protein	NNS
cord-332165-31tbc31x	104	25	.	.	.
cord-332165-31tbc31x	105	1	The	the	DT
cord-332165-31tbc31x	105	2	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	105	3	five	five	CD
cord-332165-31tbc31x	105	4	-	-	HYPH
cord-332165-31tbc31x	105	5	fold	fold	JJ
cord-332165-31tbc31x	105	6	penton	penton	NNP
cord-332165-31tbc31x	105	7	positions	position	NNS
cord-332165-31tbc31x	105	8	are	be	VBP
cord-332165-31tbc31x	105	9	occupied	occupy	VBN
cord-332165-31tbc31x	105	10	by	by	IN
cord-332165-31tbc31x	105	11	VP1	VP1	NNP
cord-332165-31tbc31x	105	12	pentamers	pentamer	NNS
cord-332165-31tbc31x	105	13	,	,	,
cord-332165-31tbc31x	105	14	which	which	WDT
cord-332165-31tbc31x	105	15	are	be	VBP
cord-332165-31tbc31x	105	16	bridged	bridge	VBN
cord-332165-31tbc31x	105	17	by	by	IN
cord-332165-31tbc31x	105	18	one	one	CD
cord-332165-31tbc31x	105	19	pseudo	pseudo	JJ
cord-332165-31tbc31x	105	20	-	-	JJ
cord-332165-31tbc31x	105	21	hexon	hexon	JJ
cord-332165-31tbc31x	105	22	capsomer	capsomer	NNP
cord-332165-31tbc31x	105	23	(	(	-LRB-
cord-332165-31tbc31x	105	24	VP2-VP3	VP2-VP3	NNP
cord-332165-31tbc31x	105	25	heterohexamer	heterohexamer	NNP
cord-332165-31tbc31x	105	26	)	)	-RRB-
cord-332165-31tbc31x	105	27	,	,	,
cord-332165-31tbc31x	105	28	giving	give	VBG
cord-332165-31tbc31x	105	29	rise	rise	NN
cord-332165-31tbc31x	105	30	to	to	IN
cord-332165-31tbc31x	105	31	pseudo	pseudo	JJ
cord-332165-31tbc31x	105	32	-	-	HYPH
cord-332165-31tbc31x	105	33	T=3	T=3	NNP
cord-332165-31tbc31x	105	34	geometry	geometry	NN
cord-332165-31tbc31x	105	35	(	(	-LRB-
cord-332165-31tbc31x	105	36	Figure	figure	NN
cord-332165-31tbc31x	105	37	3	3	CD
cord-332165-31tbc31x	105	38	)	)	-RRB-
cord-332165-31tbc31x	105	39	.	.	.
cord-332165-31tbc31x	106	1	In	in	IN
cord-332165-31tbc31x	106	2	the	the	DT
cord-332165-31tbc31x	106	3	sialic	sialic	JJ
cord-332165-31tbc31x	106	4	acid	acid	NN
cord-332165-31tbc31x	106	5	-	-	HYPH
cord-332165-31tbc31x	106	6	binding	bind	VBG
cord-332165-31tbc31x	106	7	human	human	JJ
cord-332165-31tbc31x	106	8	coxsackievirus	coxsackievirus	NN
cord-332165-31tbc31x	106	9	,	,	,
cord-332165-31tbc31x	106	10	A	a	DT
cord-332165-31tbc31x	106	11	variant	variant	JJ
cord-332165-31tbc31x	106	12	24	24	CD
cord-332165-31tbc31x	106	13	(	(	-LRB-
cord-332165-31tbc31x	106	14	CVA24v	CVA24v	VBG
cord-332165-31tbc31x	106	15	)	)	-RRB-
cord-332165-31tbc31x	106	16	,	,	,
cord-332165-31tbc31x	106	17	the	the	DT
cord-332165-31tbc31x	106	18	binding	binding	NN
cord-332165-31tbc31x	106	19	site	site	NN
cord-332165-31tbc31x	106	20	is	be	VBZ
cord-332165-31tbc31x	106	21	located	locate	VBN
cord-332165-31tbc31x	106	22	at	at	IN
cord-332165-31tbc31x	106	23	the	the	DT
cord-332165-31tbc31x	106	24	interface	interface	NN
cord-332165-31tbc31x	106	25	of	of	IN
cord-332165-31tbc31x	106	26	two	two	CD
cord-332165-31tbc31x	106	27	VP1	VP1	NNP
cord-332165-31tbc31x	106	28	protomers	protomer	NNS
cord-332165-31tbc31x	106	29	,	,	,
cord-332165-31tbc31x	106	30	close	close	JJ
cord-332165-31tbc31x	106	31	to	to	IN
cord-332165-31tbc31x	106	32	the	the	DT
cord-332165-31tbc31x	106	33	five	five	CD
cord-332165-31tbc31x	106	34	-	-	HYPH
cord-332165-31tbc31x	106	35	fold	fold	JJ
cord-332165-31tbc31x	106	36	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	106	37	axis	axis	NN
cord-332165-31tbc31x	106	38	.	.	.
cord-332165-31tbc31x	107	1	VP2	VP2	NNP
cord-332165-31tbc31x	107	2	and	and	CC
cord-332165-31tbc31x	107	3	VP3	VP3	NNP
cord-332165-31tbc31x	107	4	do	do	VBP
cord-332165-31tbc31x	107	5	not	not	RB
cord-332165-31tbc31x	107	6	bind	bind	VB
cord-332165-31tbc31x	107	7	sialic	sialic	NN
cord-332165-31tbc31x	107	8	acid	acid	NN
cord-332165-31tbc31x	107	9	,	,	,
cord-332165-31tbc31x	107	10	which	which	WDT
cord-332165-31tbc31x	107	11	results	result	VBZ
cord-332165-31tbc31x	107	12	in	in	IN
cord-332165-31tbc31x	107	13	a	a	DT
cord-332165-31tbc31x	107	14	total	total	NN
cord-332165-31tbc31x	107	15	of	of	IN
cord-332165-31tbc31x	107	16	60	60	CD
cord-332165-31tbc31x	107	17	binding	bind	VBG
cord-332165-31tbc31x	107	18	sites	site	NNS
cord-332165-31tbc31x	107	19	,	,	,
cord-332165-31tbc31x	107	20	arranged	arrange	VBN
cord-332165-31tbc31x	107	21	in	in	IN
cord-332165-31tbc31x	107	22	twelve	twelve	CD
cord-332165-31tbc31x	107	23	local	local	JJ
cord-332165-31tbc31x	107	24	five	five	CD
cord-332165-31tbc31x	107	25	-	-	HYPH
cord-332165-31tbc31x	107	26	fold	fold	JJ
cord-332165-31tbc31x	107	27	symmetries	symmetry	NNS
cord-332165-31tbc31x	107	28	(	(	-LRB-
cord-332165-31tbc31x	107	29	Figure	figure	NN
cord-332165-31tbc31x	107	30	4a	4a	CD
cord-332165-31tbc31x	107	31	)	)	-RRB-
cord-332165-31tbc31x	108	1	[	[	-LRB-
cord-332165-31tbc31x	108	2	37	37	CD
cord-332165-31tbc31x	108	3	]	]	-RRB-
cord-332165-31tbc31x	108	4	.	.	.
cord-332165-31tbc31x	109	1	The	the	DT
cord-332165-31tbc31x	109	2	distance	distance	NN
cord-332165-31tbc31x	109	3	between	between	IN
cord-332165-31tbc31x	109	4	an	an	DT
cord-332165-31tbc31x	109	5	individual	individual	JJ
cord-332165-31tbc31x	109	6	sialic	sialic	NN
cord-332165-31tbc31x	109	7	acid	acid	NN
cord-332165-31tbc31x	109	8	binding	bind	VBG
cord-332165-31tbc31x	109	9	site	site	NN
cord-332165-31tbc31x	109	10	and	and	CC
cord-332165-31tbc31x	109	11	the	the	DT
cord-332165-31tbc31x	109	12	local	local	JJ
cord-332165-31tbc31x	109	13	five	five	CD
cord-332165-31tbc31x	109	14	-	-	HYPH
cord-332165-31tbc31x	109	15	fold	fold	JJ
cord-332165-31tbc31x	109	16	rotation	rotation	NN
cord-332165-31tbc31x	109	17	axis	axis	NN
cord-332165-31tbc31x	109	18	of	of	IN
cord-332165-31tbc31x	109	19	the	the	DT
cord-332165-31tbc31x	109	20	VP1	VP1	NNP
cord-332165-31tbc31x	109	21	pentamer	pentamer	NNP
cord-332165-31tbc31x	109	22	amounts	amount	VBZ
cord-332165-31tbc31x	109	23	to	to	IN
cord-332165-31tbc31x	109	24	ca	ca	NNP
cord-332165-31tbc31x	109	25	.	.	.
cord-332165-31tbc31x	110	1	1.6	1.6	CD
cord-332165-31tbc31x	110	2	nm	nm	NN
cord-332165-31tbc31x	110	3	.	.	.
cord-332165-31tbc31x	111	1	In	in	IN
cord-332165-31tbc31x	111	2	the	the	DT
cord-332165-31tbc31x	111	3	members	member	NNS
cord-332165-31tbc31x	111	4	of	of	IN
cord-332165-31tbc31x	111	5	both	both	CC
cord-332165-31tbc31x	111	6	Papillomaviridae	Papillomaviridae	NNP
cord-332165-31tbc31x	111	7	and	and	CC
cord-332165-31tbc31x	111	8	Polyomaviridae	Polyomaviridae	NNP
cord-332165-31tbc31x	111	9	,	,	,
cord-332165-31tbc31x	111	10	single	single	JJ
cord-332165-31tbc31x	111	11	capsid	capsid	NN
cord-332165-31tbc31x	111	12	proteins	protein	NNS
cord-332165-31tbc31x	111	13	named	name	VBN
cord-332165-31tbc31x	111	14	L1	L1	NNP
cord-332165-31tbc31x	111	15	and	and	CC
cord-332165-31tbc31x	111	16	VP1	vp1	NN
cord-332165-31tbc31x	111	17	,	,	,
cord-332165-31tbc31x	111	18	respectively	respectively	RB
cord-332165-31tbc31x	111	19	,	,	,
cord-332165-31tbc31x	111	20	constitute	constitute	VBP
cord-332165-31tbc31x	111	21	the	the	DT
cord-332165-31tbc31x	111	22	outer	outer	JJ
cord-332165-31tbc31x	111	23	capsid	capsid	NN
cord-332165-31tbc31x	111	24	.	.	.
cord-332165-31tbc31x	112	1	Both	both	DT
cord-332165-31tbc31x	112	2	proteins	protein	NNS
cord-332165-31tbc31x	112	3	exclusively	exclusively	RB
cord-332165-31tbc31x	112	4	form	form	VBP
cord-332165-31tbc31x	112	5	pentamers	pentamer	NNS
cord-332165-31tbc31x	112	6	,	,	,
cord-332165-31tbc31x	112	7	which	which	WDT
cord-332165-31tbc31x	112	8	can	can	MD
cord-332165-31tbc31x	112	9	occupy	occupy	VB
cord-332165-31tbc31x	112	10	pentavalent	pentavalent	NN
cord-332165-31tbc31x	112	11	and	and	CC
cord-332165-31tbc31x	112	12	hexavalent	hexavalent	NN
cord-332165-31tbc31x	112	13	positions	position	NNS
cord-332165-31tbc31x	112	14	in	in	IN
cord-332165-31tbc31x	112	15	the	the	DT
cord-332165-31tbc31x	112	16	mature	mature	JJ
cord-332165-31tbc31x	112	17	particle	particle	NN
cord-332165-31tbc31x	112	18	,	,	,
cord-332165-31tbc31x	112	19	thus	thus	RB
cord-332165-31tbc31x	112	20	deviating	deviate	VBG
cord-332165-31tbc31x	112	21	from	from	IN
cord-332165-31tbc31x	112	22	the	the	DT
cord-332165-31tbc31x	112	23	quasi	quasi	JJ
cord-332165-31tbc31x	112	24	-	-	JJ
cord-332165-31tbc31x	112	25	equivalence	equivalence	JJ
cord-332165-31tbc31x	112	26	principle	principle	NN
cord-332165-31tbc31x	112	27	proposed	propose	VBN
cord-332165-31tbc31x	112	28	by	by	IN
cord-332165-31tbc31x	112	29	Caspar	Caspar	NNP
cord-332165-31tbc31x	112	30	and	and	CC
cord-332165-31tbc31x	112	31	Klug	Klug	NNP
cord-332165-31tbc31x	112	32	in	in	IN
cord-332165-31tbc31x	112	33	1962	1962	CD
cord-332165-31tbc31x	112	34	[	[	-LRB-
cord-332165-31tbc31x	112	35	35	35	CD
cord-332165-31tbc31x	112	36	]	]	-RRB-
cord-332165-31tbc31x	112	37	.	.	.
cord-332165-31tbc31x	113	1	Here	here	RB
cord-332165-31tbc31x	113	2	,	,	,
cord-332165-31tbc31x	113	3	a	a	DT
cord-332165-31tbc31x	113	4	total	total	JJ
cord-332165-31tbc31x	113	5	number	number	NN
cord-332165-31tbc31x	113	6	of	of	IN
cord-332165-31tbc31x	113	7	72	72	CD
cord-332165-31tbc31x	113	8	pentameric	pentameric	NN
cord-332165-31tbc31x	113	9	capsomers	capsomer	NNS
cord-332165-31tbc31x	113	10	are	be	VBP
cord-332165-31tbc31x	113	11	arranged	arrange	VBN
cord-332165-31tbc31x	113	12	in	in	IN
cord-332165-31tbc31x	113	13	a	a	DT
cord-332165-31tbc31x	113	14	T=7d	t=7d	CD
cord-332165-31tbc31x	113	15	fashion	fashion	NN
cord-332165-31tbc31x	113	16	,	,	,
cord-332165-31tbc31x	113	17	with	with	IN
cord-332165-31tbc31x	113	18	a	a	DT
cord-332165-31tbc31x	113	19	diameter	diameter	NN
cord-332165-31tbc31x	113	20	of	of	IN
cord-332165-31tbc31x	113	21	ca	ca	NNP
cord-332165-31tbc31x	113	22	.	.	.
cord-332165-31tbc31x	114	1	50	50	CD
cord-332165-31tbc31x	114	2	nm	nm	CD
cord-332165-31tbc31x	114	3	in	in	IN
cord-332165-31tbc31x	114	4	the	the	DT
cord-332165-31tbc31x	114	5	mature	mature	JJ
cord-332165-31tbc31x	114	6	particles	particle	NNS
cord-332165-31tbc31x	114	7	(	(	-LRB-
cord-332165-31tbc31x	114	8	Figure	figure	NN
cord-332165-31tbc31x	114	9	3	3	CD
cord-332165-31tbc31x	114	10	)	)	-RRB-
cord-332165-31tbc31x	115	1	[	[	-LRB-
cord-332165-31tbc31x	115	2	38	38	CD
cord-332165-31tbc31x	115	3	]	]	-RRB-
cord-332165-31tbc31x	116	1	[	[	-LRB-
cord-332165-31tbc31x	116	2	39	39	CD
cord-332165-31tbc31x	116	3	]	]	-RRB-
cord-332165-31tbc31x	116	4	[	[	-LRB-
cord-332165-31tbc31x	116	5	40	40	CD
cord-332165-31tbc31x	116	6	]	]	-RRB-
cord-332165-31tbc31x	116	7	.	.	.
cord-332165-31tbc31x	117	1	The	the	DT
cord-332165-31tbc31x	117	2	formation	formation	NN
cord-332165-31tbc31x	117	3	of	of	IN
cord-332165-31tbc31x	117	4	smaller	small	JJR
cord-332165-31tbc31x	117	5	,	,	,
cord-332165-31tbc31x	117	6	non	non	JJ
cord-332165-31tbc31x	117	7	-	-	JJ
cord-332165-31tbc31x	117	8	viable	viable	JJ
cord-332165-31tbc31x	117	9	lower	low	JJR
cord-332165-31tbc31x	117	10	-	-	HYPH
cord-332165-31tbc31x	117	11	symmetry	symmetry	NN
cord-332165-31tbc31x	117	12	T=1	T=1	NNP
cord-332165-31tbc31x	117	13	virus	virus	NN
cord-332165-31tbc31x	117	14	-	-	HYPH
cord-332165-31tbc31x	117	15	like	like	JJ
cord-332165-31tbc31x	117	16	particles	particle	NNS
cord-332165-31tbc31x	117	17	(	(	-LRB-
cord-332165-31tbc31x	117	18	VLPs	VLPs	NNP
cord-332165-31tbc31x	117	19	)	)	-RRB-
cord-332165-31tbc31x	117	20	has	have	VBZ
cord-332165-31tbc31x	117	21	also	also	RB
cord-332165-31tbc31x	117	22	been	be	VBN
cord-332165-31tbc31x	117	23	described	describe	VBN
cord-332165-31tbc31x	117	24	for	for	IN
cord-332165-31tbc31x	117	25	both	both	DT
cord-332165-31tbc31x	117	26	papillomaviruses	papillomaviruse	NNS
cord-332165-31tbc31x	117	27	and	and	CC
cord-332165-31tbc31x	117	28	polyomaviruses	polyomaviruse	NNS
cord-332165-31tbc31x	117	29	[	[	-LRB-
cord-332165-31tbc31x	117	30	41	41	CD
cord-332165-31tbc31x	117	31	]	]	-RRB-
cord-332165-31tbc31x	117	32	[	[	-LRB-
cord-332165-31tbc31x	117	33	42	42	CD
cord-332165-31tbc31x	117	34	]	]	-RRB-
cord-332165-31tbc31x	117	35	[	[	-LRB-
cord-332165-31tbc31x	117	36	43	43	CD
cord-332165-31tbc31x	117	37	]	]	-RRB-
cord-332165-31tbc31x	117	38	.	.	.
cord-332165-31tbc31x	118	1	Many	many	JJ
cord-332165-31tbc31x	118	2	members	member	NNS
cord-332165-31tbc31x	118	3	of	of	IN
cord-332165-31tbc31x	118	4	the	the	DT
cord-332165-31tbc31x	118	5	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	118	6	family	family	NN
cord-332165-31tbc31x	118	7	bind	bind	VB
cord-332165-31tbc31x	118	8	sialic	sialic	NN
cord-332165-31tbc31x	118	9	acid	acid	NN
cord-332165-31tbc31x	118	10	-	-	HYPH
cord-332165-31tbc31x	118	11	based	base	VBN
cord-332165-31tbc31x	118	12	glycans	glycan	NNS
cord-332165-31tbc31x	118	13	using	use	VBG
cord-332165-31tbc31x	118	14	their	-PRON-	PRP$
cord-332165-31tbc31x	118	15	VP1	vp1	NN
cord-332165-31tbc31x	118	16	proteins	protein	NNS
cord-332165-31tbc31x	118	17	,	,	,
cord-332165-31tbc31x	118	18	so	so	IN
cord-332165-31tbc31x	118	19	the	the	DT
cord-332165-31tbc31x	118	20	binding	bind	VBG
cord-332165-31tbc31x	118	21	sites	site	NNS
cord-332165-31tbc31x	118	22	on	on	IN
cord-332165-31tbc31x	118	23	individual	individual	JJ
cord-332165-31tbc31x	118	24	pentamers	pentamer	NNS
cord-332165-31tbc31x	118	25	are	be	VBP
cord-332165-31tbc31x	118	26	always	always	RB
cord-332165-31tbc31x	118	27	linked	link	VBN
cord-332165-31tbc31x	118	28	by	by	IN
cord-332165-31tbc31x	118	29	local	local	JJ
cord-332165-31tbc31x	118	30	five	five	CD
cord-332165-31tbc31x	118	31	-	-	HYPH
cord-332165-31tbc31x	118	32	fold	fold	JJ
cord-332165-31tbc31x	118	33	symmetry	symmetry	NN
cord-332165-31tbc31x	118	34	(	(	-LRB-
cord-332165-31tbc31x	118	35	Figure	figure	NN
cord-332165-31tbc31x	118	36	4a	4a	CD
cord-332165-31tbc31x	118	37	,	,	,
cord-332165-31tbc31x	118	38	TSPyV	tspyv	NN
cord-332165-31tbc31x	118	39	)	)	-RRB-
cord-332165-31tbc31x	118	40	.	.	.
cord-332165-31tbc31x	119	1	In	in	IN
cord-332165-31tbc31x	119	2	all	all	DT
cord-332165-31tbc31x	119	3	structures	structure	NNS
cord-332165-31tbc31x	119	4	of	of	IN
cord-332165-31tbc31x	119	5	polyomavirus	polyomavirus	JJ
cord-332165-31tbc31x	119	6	-	-	HYPH
cord-332165-31tbc31x	119	7	sialyl	sialyl	JJ
cord-332165-31tbc31x	119	8	-	-	HYPH
cord-332165-31tbc31x	119	9	oligosaccharide	oligosaccharide	NN
cord-332165-31tbc31x	119	10	complexes	complex	NNS
cord-332165-31tbc31x	119	11	,	,	,
cord-332165-31tbc31x	119	12	the	the	DT
cord-332165-31tbc31x	119	13	majority	majority	NN
cord-332165-31tbc31x	119	14	of	of	IN
cord-332165-31tbc31x	119	15	contacts	contact	NNS
cord-332165-31tbc31x	119	16	between	between	IN
cord-332165-31tbc31x	119	17	the	the	DT
cord-332165-31tbc31x	119	18	protein	protein	NN
cord-332165-31tbc31x	119	19	and	and	CC
cord-332165-31tbc31x	119	20	receptor	receptor	NN
cord-332165-31tbc31x	119	21	can	can	MD
cord-332165-31tbc31x	119	22	be	be	VB
cord-332165-31tbc31x	119	23	attributed	attribute	VBN
cord-332165-31tbc31x	119	24	to	to	IN
cord-332165-31tbc31x	119	25	sialic	sialic	JJ
cord-332165-31tbc31x	119	26	acid	acid	NN
cord-332165-31tbc31x	119	27	,	,	,
cord-332165-31tbc31x	119	28	with	with	IN
cord-332165-31tbc31x	119	29	a	a	DT
cord-332165-31tbc31x	119	30	small	small	JJ
cord-332165-31tbc31x	119	31	number	number	NN
cord-332165-31tbc31x	119	32	of	of	IN
cord-332165-31tbc31x	119	33	augmenting	augment	VBG
cord-332165-31tbc31x	119	34	contacts	contact	NNS
cord-332165-31tbc31x	119	35	to	to	IN
cord-332165-31tbc31x	119	36	other	other	JJ
cord-332165-31tbc31x	119	37	saccharides	saccharide	NNS
cord-332165-31tbc31x	119	38	providing	provide	VBG
cord-332165-31tbc31x	119	39	specificity	specificity	NN
cord-332165-31tbc31x	119	40	for	for	IN
cord-332165-31tbc31x	119	41	a	a	DT
cord-332165-31tbc31x	119	42	given	give	VBN
cord-332165-31tbc31x	119	43	glycan	glycan	NN
cord-332165-31tbc31x	119	44	structure	structure	NN
cord-332165-31tbc31x	119	45	[	[	-LRB-
cord-332165-31tbc31x	119	46	27	27	CD
cord-332165-31tbc31x	119	47	,	,	,
cord-332165-31tbc31x	119	48	[	[	-LRB-
cord-332165-31tbc31x	119	49	44	44	CD
cord-332165-31tbc31x	119	50	]	]	-RRB-
cord-332165-31tbc31x	119	51	[	[	-LRB-
cord-332165-31tbc31x	119	52	45	45	CD
cord-332165-31tbc31x	119	53	]	]	-RRB-
cord-332165-31tbc31x	119	54	[	[	-LRB-
cord-332165-31tbc31x	119	55	46	46	CD
cord-332165-31tbc31x	119	56	]	]	-RRB-
cord-332165-31tbc31x	119	57	[	[	-LRB-
cord-332165-31tbc31x	119	58	47	47	CD
cord-332165-31tbc31x	119	59	]	]	-RRB-
cord-332165-31tbc31x	119	60	[	[	-LRB-
cord-332165-31tbc31x	119	61	48	48	CD
cord-332165-31tbc31x	119	62	]	]	-RRB-
cord-332165-31tbc31x	119	63	[	[	-LRB-
cord-332165-31tbc31x	119	64	49	49	CD
cord-332165-31tbc31x	119	65	]	]	-RRB-
cord-332165-31tbc31x	119	66	[	[	-LRB-
cord-332165-31tbc31x	119	67	50	50	CD
cord-332165-31tbc31x	119	68	]	]	-RRB-
cord-332165-31tbc31x	119	69	.	.	.
cord-332165-31tbc31x	120	1	In	in	IN
cord-332165-31tbc31x	120	2	contrast	contrast	NN
cord-332165-31tbc31x	120	3	,	,	,
cord-332165-31tbc31x	120	4	papillomaviruses	papillomaviruse	NNS
cord-332165-31tbc31x	120	5	do	do	VBP
cord-332165-31tbc31x	120	6	not	not	RB
cord-332165-31tbc31x	120	7	bind	bind	VB
cord-332165-31tbc31x	120	8	sialylated	sialylated	JJ
cord-332165-31tbc31x	120	9	receptors	receptor	NNS
cord-332165-31tbc31x	120	10	,	,	,
cord-332165-31tbc31x	120	11	but	but	CC
cord-332165-31tbc31x	120	12	instead	instead	RB
cord-332165-31tbc31x	120	13	interact	interact	VB
cord-332165-31tbc31x	120	14	with	with	IN
cord-332165-31tbc31x	120	15	glycosaminoglycans	glycosaminoglycan	NNS
cord-332165-31tbc31x	120	16	to	to	TO
cord-332165-31tbc31x	120	17	adhere	adhere	VB
cord-332165-31tbc31x	120	18	to	to	IN
cord-332165-31tbc31x	120	19	cells	cell	NNS
cord-332165-31tbc31x	120	20	[	[	-LRB-
cord-332165-31tbc31x	120	21	51	51	CD
cord-332165-31tbc31x	120	22	]	]	-RRB-
cord-332165-31tbc31x	121	1	[	[	-LRB-
cord-332165-31tbc31x	121	2	52	52	CD
cord-332165-31tbc31x	121	3	]	]	-RRB-
cord-332165-31tbc31x	122	1	[	[	-LRB-
cord-332165-31tbc31x	122	2	53	53	CD
cord-332165-31tbc31x	122	3	]	]	-RRB-
cord-332165-31tbc31x	122	4	.	.	.
cord-332165-31tbc31x	123	1	Reoviridae	Reoviridae	NNP
cord-332165-31tbc31x	123	2	are	be	VBP
cord-332165-31tbc31x	123	3	a	a	DT
cord-332165-31tbc31x	123	4	large	large	JJ
cord-332165-31tbc31x	123	5	family	family	NN
cord-332165-31tbc31x	123	6	including	include	VBG
cord-332165-31tbc31x	123	7	,	,	,
cord-332165-31tbc31x	123	8	among	among	IN
cord-332165-31tbc31x	123	9	others	other	NNS
cord-332165-31tbc31x	123	10	,	,	,
cord-332165-31tbc31x	123	11	the	the	DT
cord-332165-31tbc31x	123	12	genera	genus	NNS
cord-332165-31tbc31x	123	13	of	of	IN
cord-332165-31tbc31x	123	14	orthoreoviruses	orthoreoviruse	NNS
cord-332165-31tbc31x	123	15	and	and	CC
cord-332165-31tbc31x	123	16	rotaviruses	rotaviruses	NNP
cord-332165-31tbc31x	123	17	.	.	.
cord-332165-31tbc31x	124	1	Members	member	NNS
cord-332165-31tbc31x	124	2	of	of	IN
cord-332165-31tbc31x	124	3	the	the	DT
cord-332165-31tbc31x	124	4	Reoviridae	Reoviridae	NNP
cord-332165-31tbc31x	124	5	family	family	NN
cord-332165-31tbc31x	124	6	are	be	VBP
cord-332165-31tbc31x	124	7	double	double	RB
cord-332165-31tbc31x	124	8	-	-	HYPH
cord-332165-31tbc31x	124	9	shelled	shell	VBN
cord-332165-31tbc31x	124	10	particles	particle	NNS
cord-332165-31tbc31x	124	11	,	,	,
cord-332165-31tbc31x	124	12	in	in	IN
cord-332165-31tbc31x	124	13	which	which	WDT
cord-332165-31tbc31x	124	14	the	the	DT
cord-332165-31tbc31x	124	15	inner	inner	JJ
cord-332165-31tbc31x	124	16	core	core	NN
cord-332165-31tbc31x	124	17	layer	layer	NN
cord-332165-31tbc31x	124	18	consists	consist	VBZ
cord-332165-31tbc31x	124	19	of	of	IN
cord-332165-31tbc31x	124	20	two	two	CD
cord-332165-31tbc31x	124	21	core	core	NN
cord-332165-31tbc31x	124	22	proteins	protein	NNS
cord-332165-31tbc31x	124	23	arranged	arrange	VBN
cord-332165-31tbc31x	124	24	in	in	IN
cord-332165-31tbc31x	124	25	a	a	DT
cord-332165-31tbc31x	124	26	T=2	t=2	CD
cord-332165-31tbc31x	124	27	*	*	NFP
cord-332165-31tbc31x	124	28	order	order	NN
cord-332165-31tbc31x	124	29	and	and	CC
cord-332165-31tbc31x	124	30	the	the	DT
cord-332165-31tbc31x	124	31	outer	outer	JJ
cord-332165-31tbc31x	124	32	capsid	capsid	NN
cord-332165-31tbc31x	124	33	possesses	possess	VBZ
cord-332165-31tbc31x	124	34	T=13	t=13	JJ
cord-332165-31tbc31x	124	35	geometry	geometry	NN
cord-332165-31tbc31x	124	36	[	[	-LRB-
cord-332165-31tbc31x	124	37	54	54	CD
cord-332165-31tbc31x	124	38	]	]	-RRB-
cord-332165-31tbc31x	125	1	[	[	-LRB-
cord-332165-31tbc31x	125	2	55	55	CD
cord-332165-31tbc31x	125	3	]	]	-RRB-
cord-332165-31tbc31x	125	4	[	[	-LRB-
cord-332165-31tbc31x	125	5	56	56	CD
cord-332165-31tbc31x	125	6	]	]	-RRB-
cord-332165-31tbc31x	125	7	.	.	.
cord-332165-31tbc31x	126	1	The	the	DT
cord-332165-31tbc31x	126	2	diameter	diameter	NN
cord-332165-31tbc31x	126	3	of	of	IN
cord-332165-31tbc31x	126	4	mature	mature	JJ
cord-332165-31tbc31x	126	5	virions	virion	NNS
cord-332165-31tbc31x	126	6	is	be	VBZ
cord-332165-31tbc31x	126	7	about	about	RB
cord-332165-31tbc31x	126	8	60	60	CD
cord-332165-31tbc31x	126	9	-	-	SYM
cord-332165-31tbc31x	126	10	80	80	CD
cord-332165-31tbc31x	126	11	nm	nm	NN
cord-332165-31tbc31x	126	12	(	(	-LRB-
cord-332165-31tbc31x	126	13	Figure	figure	NN
cord-332165-31tbc31x	126	14	3	3	CD
cord-332165-31tbc31x	126	15	)	)	-RRB-
cord-332165-31tbc31x	126	16	.	.	.
cord-332165-31tbc31x	127	1	In	in	IN
cord-332165-31tbc31x	127	2	the	the	DT
cord-332165-31tbc31x	127	3	case	case	NN
cord-332165-31tbc31x	127	4	of	of	IN
cord-332165-31tbc31x	127	5	mammalian	mammalian	JJ
cord-332165-31tbc31x	127	6	reoviruses	reovirus	NNS
cord-332165-31tbc31x	127	7	,	,	,
cord-332165-31tbc31x	127	8	the	the	DT
cord-332165-31tbc31x	127	9	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	127	10	vertex	vertex	NN
cord-332165-31tbc31x	127	11	positions	position	NNS
cord-332165-31tbc31x	127	12	are	be	VBP
cord-332165-31tbc31x	127	13	occupied	occupy	VBN
cord-332165-31tbc31x	127	14	by	by	IN
cord-332165-31tbc31x	127	15	the	the	DT
cord-332165-31tbc31x	127	16	trimeric	trimeric	NNP
cord-332165-31tbc31x	127	17	attachment	attachment	NN
cord-332165-31tbc31x	127	18	protein	protein	NNP
cord-332165-31tbc31x	127	19	sigma1	sigma1	NNP
cord-332165-31tbc31x	127	20	,	,	,
cord-332165-31tbc31x	127	21	which	which	WDT
cord-332165-31tbc31x	127	22	markedly	markedly	RB
cord-332165-31tbc31x	127	23	protrudes	protrude	VBZ
cord-332165-31tbc31x	127	24	as	as	IN
cord-332165-31tbc31x	127	25	a	a	DT
cord-332165-31tbc31x	127	26	thin	thin	JJ
cord-332165-31tbc31x	127	27	fiber	fiber	NN
cord-332165-31tbc31x	127	28	from	from	IN
cord-332165-31tbc31x	127	29	the	the	DT
cord-332165-31tbc31x	127	30	virion	virion	NN
cord-332165-31tbc31x	127	31	surface	surface	NN
cord-332165-31tbc31x	127	32	.	.	.
cord-332165-31tbc31x	128	1	The	the	DT
cord-332165-31tbc31x	128	2	sigma1	sigma1	NN
cord-332165-31tbc31x	128	3	protein	protein	NN
cord-332165-31tbc31x	128	4	is	be	VBZ
cord-332165-31tbc31x	128	5	about	about	RB
cord-332165-31tbc31x	128	6	50	50	CD
cord-332165-31tbc31x	128	7	nm	nm	RB
cord-332165-31tbc31x	128	8	long	long	RB
cord-332165-31tbc31x	128	9	and	and	CC
cord-332165-31tbc31x	128	10	has	have	VBZ
cord-332165-31tbc31x	128	11	a	a	DT
cord-332165-31tbc31x	128	12	head	head	NN
cord-332165-31tbc31x	128	13	-	-	HYPH
cord-332165-31tbc31x	128	14	and	and	CC
cord-332165-31tbc31x	128	15	-	-	HYPH
cord-332165-31tbc31x	128	16	tail	tail	NN
cord-332165-31tbc31x	128	17	morphology	morphology	NN
cord-332165-31tbc31x	128	18	,	,	,
cord-332165-31tbc31x	128	19	with	with	IN
cord-332165-31tbc31x	128	20	a	a	DT
cord-332165-31tbc31x	128	21	globular	globular	JJ
cord-332165-31tbc31x	128	22	head	head	NN
cord-332165-31tbc31x	128	23	domain	domain	NN
cord-332165-31tbc31x	128	24	and	and	CC
cord-332165-31tbc31x	128	25	an	an	DT
cord-332165-31tbc31x	128	26	elongated	elongated	JJ
cord-332165-31tbc31x	128	27	tail	tail	NN
cord-332165-31tbc31x	128	28	that	that	WDT
cord-332165-31tbc31x	128	29	has	have	VBZ
cord-332165-31tbc31x	128	30	flexible	flexible	JJ
cord-332165-31tbc31x	128	31	regions	region	NNS
cord-332165-31tbc31x	128	32	and	and	CC
cord-332165-31tbc31x	128	33	partially	partially	RB
cord-332165-31tbc31x	128	34	inserts	insert	VBZ
cord-332165-31tbc31x	128	35	into	into	IN
cord-332165-31tbc31x	128	36	the	the	DT
cord-332165-31tbc31x	128	37	virion	virion	NN
cord-332165-31tbc31x	128	38	[	[	-LRB-
cord-332165-31tbc31x	128	39	57	57	CD
cord-332165-31tbc31x	128	40	]	]	-RRB-
cord-332165-31tbc31x	128	41	.	.	.
cord-332165-31tbc31x	129	1	The	the	DT
cord-332165-31tbc31x	129	2	location	location	NN
cord-332165-31tbc31x	129	3	of	of	IN
cord-332165-31tbc31x	129	4	sialic	sialic	JJ
cord-332165-31tbc31x	129	5	acid	acid	NN
cord-332165-31tbc31x	129	6	binding	binding	NN
cord-332165-31tbc31x	129	7	is	be	VBZ
cord-332165-31tbc31x	129	8	type	type	NN
cord-332165-31tbc31x	129	9	dependent	dependent	JJ
cord-332165-31tbc31x	129	10	.	.	.
cord-332165-31tbc31x	130	1	Type	type	NN
cord-332165-31tbc31x	130	2	1	1	CD
cord-332165-31tbc31x	130	3	reoviruses	reovirus	NNS
cord-332165-31tbc31x	130	4	bind	bind	VBP
cord-332165-31tbc31x	130	5	sialylated	sialylated	JJ
cord-332165-31tbc31x	130	6	receptors	receptor	NNS
cord-332165-31tbc31x	130	7	in	in	IN
cord-332165-31tbc31x	130	8	the	the	DT
cord-332165-31tbc31x	130	9	protruding	protruding	JJ
cord-332165-31tbc31x	130	10	head	head	NN
cord-332165-31tbc31x	130	11	domain	domain	NN
cord-332165-31tbc31x	130	12	while	while	IN
cord-332165-31tbc31x	130	13	type	type	NN
cord-332165-31tbc31x	130	14	3	3	CD
cord-332165-31tbc31x	130	15	reoviruses	reovirus	NNS
cord-332165-31tbc31x	130	16	use	use	VBP
cord-332165-31tbc31x	130	17	a	a	DT
cord-332165-31tbc31x	130	18	binding	binding	JJ
cord-332165-31tbc31x	130	19	site	site	NN
cord-332165-31tbc31x	130	20	in	in	IN
cord-332165-31tbc31x	130	21	a	a	DT
cord-332165-31tbc31x	130	22	region	region	NN
cord-332165-31tbc31x	130	23	near	near	IN
cord-332165-31tbc31x	130	24	the	the	DT
cord-332165-31tbc31x	130	25	mid	mid	JJ
cord-332165-31tbc31x	130	26	-	-	NN
cord-332165-31tbc31x	130	27	point	point	NN
cord-332165-31tbc31x	130	28	of	of	IN
cord-332165-31tbc31x	130	29	the	the	DT
cord-332165-31tbc31x	130	30	tail	tail	NN
cord-332165-31tbc31x	130	31	(	(	-LRB-
cord-332165-31tbc31x	130	32	Figure	figure	NN
cord-332165-31tbc31x	130	33	4b	4b	NNS
cord-332165-31tbc31x	130	34	,	,	,
cord-332165-31tbc31x	130	35	ReoV	ReoV	NNP
cord-332165-31tbc31x	130	36	T3D	T3D	NNP
cord-332165-31tbc31x	130	37	and	and	CC
cord-332165-31tbc31x	130	38	T1L	T1L	NNS
cord-332165-31tbc31x	130	39	)	)	-RRB-
cord-332165-31tbc31x	130	40	[	[	-LRB-
cord-332165-31tbc31x	130	41	58	58	CD
cord-332165-31tbc31x	130	42	,	,	,
cord-332165-31tbc31x	130	43	59	59	CD
cord-332165-31tbc31x	130	44	]	]	-RRB-
cord-332165-31tbc31x	130	45	.	.	.
cord-332165-31tbc31x	131	1	Both	both	DT
cord-332165-31tbc31x	131	2	sites	site	NNS
cord-332165-31tbc31x	131	3	primarily	primarily	RB
cord-332165-31tbc31x	131	4	engage	engage	VBP
cord-332165-31tbc31x	131	5	sialic	sialic	JJ
cord-332165-31tbc31x	131	6	acid	acid	NN
cord-332165-31tbc31x	131	7	with	with	IN
cord-332165-31tbc31x	131	8	a	a	DT
cord-332165-31tbc31x	131	9	small	small	JJ
cord-332165-31tbc31x	131	10	number	number	NN
cord-332165-31tbc31x	131	11	of	of	IN
cord-332165-31tbc31x	131	12	contacts	contact	NNS
cord-332165-31tbc31x	131	13	,	,	,
cord-332165-31tbc31x	131	14	and	and	CC
cord-332165-31tbc31x	131	15	in	in	IN
cord-332165-31tbc31x	131	16	both	both	DT
cord-332165-31tbc31x	131	17	cases	case	NNS
cord-332165-31tbc31x	131	18	,	,	,
cord-332165-31tbc31x	131	19	three	three	CD
cord-332165-31tbc31x	131	20	-	-	HYPH
cord-332165-31tbc31x	131	21	fold	fold	JJ
cord-332165-31tbc31x	131	22	rotational	rotational	JJ
cord-332165-31tbc31x	131	23	symmetry	symmetry	NN
cord-332165-31tbc31x	131	24	is	be	VBZ
cord-332165-31tbc31x	131	25	found	find	VBN
cord-332165-31tbc31x	131	26	between	between	IN
cord-332165-31tbc31x	131	27	the	the	DT
cord-332165-31tbc31x	131	28	binding	bind	VBG
cord-332165-31tbc31x	131	29	sites	site	NNS
cord-332165-31tbc31x	131	30	within	within	IN
cord-332165-31tbc31x	131	31	a	a	DT
cord-332165-31tbc31x	131	32	single	single	JJ
cord-332165-31tbc31x	131	33	sigma1	sigma1	NN
cord-332165-31tbc31x	131	34	trimer	trimer	NN
cord-332165-31tbc31x	131	35	.	.	.
cord-332165-31tbc31x	132	1	Thus	thus	RB
cord-332165-31tbc31x	132	2	,	,	,
cord-332165-31tbc31x	132	3	12	12	CD
cord-332165-31tbc31x	132	4	sigma1	sigma1	NN
cord-332165-31tbc31x	132	5	trimers	trimer	NNS
cord-332165-31tbc31x	132	6	give	give	VBP
cord-332165-31tbc31x	132	7	rise	rise	NN
cord-332165-31tbc31x	132	8	to	to	IN
cord-332165-31tbc31x	132	9	36	36	CD
cord-332165-31tbc31x	132	10	sialic	sialic	NN
cord-332165-31tbc31x	132	11	acid	acid	NN
cord-332165-31tbc31x	132	12	binding	bind	VBG
cord-332165-31tbc31x	132	13	sites	site	NNS
cord-332165-31tbc31x	132	14	in	in	IN
cord-332165-31tbc31x	132	15	orthoreoviruses	orthoreoviruse	NNS
cord-332165-31tbc31x	132	16	.	.	.
cord-332165-31tbc31x	133	1	Rotaviruses	Rotaviruses	NNP
cord-332165-31tbc31x	133	2	also	also	RB
cord-332165-31tbc31x	133	3	have	have	VBP
cord-332165-31tbc31x	133	4	protruding	protruding	JJ
cord-332165-31tbc31x	133	5	domains	domain	NNS
cord-332165-31tbc31x	133	6	that	that	WDT
cord-332165-31tbc31x	133	7	recognize	recognize	VBP
cord-332165-31tbc31x	133	8	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	133	9	receptors	receptor	NNS
cord-332165-31tbc31x	133	10	,	,	,
cord-332165-31tbc31x	133	11	which	which	WDT
cord-332165-31tbc31x	133	12	are	be	VBP
cord-332165-31tbc31x	133	13	also	also	RB
cord-332165-31tbc31x	133	14	dimers	dimer	NNS
cord-332165-31tbc31x	133	15	of	of	IN
cord-332165-31tbc31x	133	16	the	the	DT
cord-332165-31tbc31x	133	17	virus	virus	NN
cord-332165-31tbc31x	133	18	protein	protein	NN
cord-332165-31tbc31x	133	19	4	4	CD
cord-332165-31tbc31x	133	20	(	(	-LRB-
cord-332165-31tbc31x	133	21	VP4	VP4	NNP
cord-332165-31tbc31x	133	22	)	)	-RRB-
cord-332165-31tbc31x	133	23	[	[	-LRB-
cord-332165-31tbc31x	133	24	60	60	CD
cord-332165-31tbc31x	133	25	]	]	-RRB-
cord-332165-31tbc31x	133	26	.	.	.
cord-332165-31tbc31x	134	1	While	while	IN
cord-332165-31tbc31x	134	2	some	some	DT
cord-332165-31tbc31x	134	3	of	of	IN
cord-332165-31tbc31x	134	4	the	the	DT
cord-332165-31tbc31x	134	5	more	more	RBR
cord-332165-31tbc31x	134	6	pathogenic	pathogenic	JJ
cord-332165-31tbc31x	134	7	human	human	JJ
cord-332165-31tbc31x	134	8	viruses	virus	NNS
cord-332165-31tbc31x	134	9	bind	bind	VBP
cord-332165-31tbc31x	134	10	HBGAs	hbga	NNS
cord-332165-31tbc31x	134	11	,	,	,
cord-332165-31tbc31x	134	12	animal	animal	NN
cord-332165-31tbc31x	134	13	rotaviruses	rotavirus	NNS
cord-332165-31tbc31x	134	14	primarily	primarily	RB
cord-332165-31tbc31x	134	15	engage	engage	VB
cord-332165-31tbc31x	134	16	sialic	sialic	JJ
cord-332165-31tbc31x	134	17	acid	acid	NN
cord-332165-31tbc31x	134	18	-	-	HYPH
cord-332165-31tbc31x	134	19	based	base	VBN
cord-332165-31tbc31x	134	20	receptors	receptor	NNS
cord-332165-31tbc31x	134	21	[	[	-LRB-
cord-332165-31tbc31x	134	22	61	61	CD
cord-332165-31tbc31x	134	23	]	]	-RRB-
cord-332165-31tbc31x	135	1	[	[	-LRB-
cord-332165-31tbc31x	135	2	62	62	CD
cord-332165-31tbc31x	135	3	]	]	-RRB-
cord-332165-31tbc31x	135	4	[	[	-LRB-
cord-332165-31tbc31x	135	5	63	63	CD
cord-332165-31tbc31x	135	6	]	]	-RRB-
cord-332165-31tbc31x	135	7	.	.	.
cord-332165-31tbc31x	136	1	Each	each	DT
cord-332165-31tbc31x	136	2	rotavirus	rotavirus	JJ
cord-332165-31tbc31x	136	3	VP4	vp4	JJ
cord-332165-31tbc31x	136	4	subunit	subunit	NN
cord-332165-31tbc31x	136	5	carries	carry	VBZ
cord-332165-31tbc31x	136	6	a	a	DT
cord-332165-31tbc31x	136	7	single	single	JJ
cord-332165-31tbc31x	136	8	sialic	sialic	NN
cord-332165-31tbc31x	136	9	acid	acid	NN
cord-332165-31tbc31x	136	10	binding	binding	NN
cord-332165-31tbc31x	136	11	site	site	NN
cord-332165-31tbc31x	136	12	,	,	,
cord-332165-31tbc31x	136	13	which	which	WDT
cord-332165-31tbc31x	136	14	is	be	VBZ
cord-332165-31tbc31x	136	15	related	relate	VBN
cord-332165-31tbc31x	136	16	to	to	IN
cord-332165-31tbc31x	136	17	the	the	DT
cord-332165-31tbc31x	136	18	two	two	CD
cord-332165-31tbc31x	136	19	-	-	HYPH
cord-332165-31tbc31x	136	20	fold	fold	JJ
cord-332165-31tbc31x	136	21	rotational	rotational	JJ
cord-332165-31tbc31x	136	22	symmetry	symmetry	NN
cord-332165-31tbc31x	136	23	in	in	IN
cord-332165-31tbc31x	136	24	the	the	DT
cord-332165-31tbc31x	136	25	dimer	dimer	NN
cord-332165-31tbc31x	136	26	(	(	-LRB-
cord-332165-31tbc31x	136	27	Figure	figure	NN
cord-332165-31tbc31x	136	28	4a	4a	CD
cord-332165-31tbc31x	136	29	,	,	,
cord-332165-31tbc31x	136	30	RRV	RRV	NNP
cord-332165-31tbc31x	136	31	)	)	-RRB-
cord-332165-31tbc31x	136	32	[	[	-LRB-
cord-332165-31tbc31x	136	33	64	64	CD
cord-332165-31tbc31x	136	34	]	]	-RRB-
cord-332165-31tbc31x	136	35	.	.	.
cord-332165-31tbc31x	137	1	In	in	IN
cord-332165-31tbc31x	137	2	further	further	JJ
cord-332165-31tbc31x	137	3	contrast	contrast	NN
cord-332165-31tbc31x	137	4	to	to	IN
cord-332165-31tbc31x	137	5	orthoreoviruses	orthoreoviruse	NNS
cord-332165-31tbc31x	137	6	,	,	,
cord-332165-31tbc31x	137	7	these	these	DT
cord-332165-31tbc31x	137	8	fibers	fiber	NNS
cord-332165-31tbc31x	137	9	do	do	VBP
cord-332165-31tbc31x	137	10	not	not	RB
cord-332165-31tbc31x	137	11	coincide	coincide	VB
cord-332165-31tbc31x	137	12	with	with	IN
cord-332165-31tbc31x	137	13	the	the	DT
cord-332165-31tbc31x	137	14	five	five	CD
cord-332165-31tbc31x	137	15	-	-	JJ
cord-332165-31tbc31x	137	16	fold	fold	JJ
cord-332165-31tbc31x	137	17	vertices	vertex	NNS
cord-332165-31tbc31x	137	18	but	but	CC
cord-332165-31tbc31x	138	1	rather	rather	RB
cord-332165-31tbc31x	138	2	associate	associate	VB
cord-332165-31tbc31x	138	3	at	at	IN
cord-332165-31tbc31x	138	4	the	the	DT
cord-332165-31tbc31x	138	5	margins	margin	NNS
cord-332165-31tbc31x	138	6	of	of	IN
cord-332165-31tbc31x	138	7	the	the	DT
cord-332165-31tbc31x	138	8	five	five	CD
cord-332165-31tbc31x	138	9	capsomers	capsomer	NNS
cord-332165-31tbc31x	138	10	around	around	IN
cord-332165-31tbc31x	138	11	the	the	DT
cord-332165-31tbc31x	138	12	five	five	CD
cord-332165-31tbc31x	138	13	-	-	JJ
cord-332165-31tbc31x	138	14	fold	fold	JJ
cord-332165-31tbc31x	138	15	vertices	vertex	NNS
cord-332165-31tbc31x	138	16	,	,	,
cord-332165-31tbc31x	138	17	resulting	result	VBG
cord-332165-31tbc31x	138	18	in	in	IN
cord-332165-31tbc31x	138	19	a	a	DT
cord-332165-31tbc31x	138	20	total	total	JJ
cord-332165-31tbc31x	138	21	number	number	NN
cord-332165-31tbc31x	138	22	of	of	IN
cord-332165-31tbc31x	138	23	60	60	CD
cord-332165-31tbc31x	138	24	VP4	vp4	JJ
cord-332165-31tbc31x	138	25	dimers	dimer	NNS
cord-332165-31tbc31x	138	26	and	and	CC
cord-332165-31tbc31x	138	27	120	120	CD
cord-332165-31tbc31x	138	28	sialic	sialic	JJ
cord-332165-31tbc31x	138	29	acid	acid	NN
cord-332165-31tbc31x	138	30	binding	bind	VBG
cord-332165-31tbc31x	138	31	sites	site	NNS
cord-332165-31tbc31x	138	32	[	[	-LRB-
cord-332165-31tbc31x	138	33	65	65	CD
cord-332165-31tbc31x	138	34	]	]	-RRB-
cord-332165-31tbc31x	138	35	.	.	.
cord-332165-31tbc31x	139	1	Adenoviridae	Adenoviridae	NNP
cord-332165-31tbc31x	139	2	members	member	NNS
cord-332165-31tbc31x	139	3	are	be	VBP
cord-332165-31tbc31x	139	4	large	large	JJ
cord-332165-31tbc31x	139	5	viruses	virus	NNS
cord-332165-31tbc31x	139	6	with	with	IN
cord-332165-31tbc31x	139	7	a	a	DT
cord-332165-31tbc31x	139	8	diameter	diameter	NN
cord-332165-31tbc31x	139	9	of	of	IN
cord-332165-31tbc31x	139	10	about	about	RB
cord-332165-31tbc31x	139	11	90	90	CD
cord-332165-31tbc31x	139	12	nm	nm	NN
cord-332165-31tbc31x	139	13	and	and	CC
cord-332165-31tbc31x	139	14	a	a	DT
cord-332165-31tbc31x	139	15	T=25	T=25	NNP
cord-332165-31tbc31x	139	16	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	139	17	capsid	capsid	NN
cord-332165-31tbc31x	139	18	(	(	-LRB-
cord-332165-31tbc31x	139	19	Figure	figure	NN
cord-332165-31tbc31x	139	20	3	3	CD
cord-332165-31tbc31x	139	21	)	)	-RRB-
cord-332165-31tbc31x	139	22	[	[	-LRB-
cord-332165-31tbc31x	139	23	66	66	CD
cord-332165-31tbc31x	139	24	,	,	,
cord-332165-31tbc31x	139	25	67	67	CD
cord-332165-31tbc31x	139	26	]	]	-RRB-
cord-332165-31tbc31x	139	27	.	.	.
cord-332165-31tbc31x	140	1	They	-PRON-	PRP
cord-332165-31tbc31x	140	2	display	display	VBP
cord-332165-31tbc31x	140	3	trimeric	trimeric	JJ
cord-332165-31tbc31x	140	4	fibrous	fibrous	JJ
cord-332165-31tbc31x	140	5	attachment	attachment	NN
cord-332165-31tbc31x	140	6	proteins	protein	NNS
cord-332165-31tbc31x	140	7	,	,	,
cord-332165-31tbc31x	140	8	known	know	VBN
cord-332165-31tbc31x	140	9	as	as	IN
cord-332165-31tbc31x	140	10	the	the	DT
cord-332165-31tbc31x	140	11	fiber	fiber	NN
cord-332165-31tbc31x	140	12	,	,	,
cord-332165-31tbc31x	140	13	at	at	IN
cord-332165-31tbc31x	140	14	their	-PRON-	PRP$
cord-332165-31tbc31x	140	15	icosahedral	icosahedral	JJ
cord-332165-31tbc31x	140	16	vertices	vertex	NNS
cord-332165-31tbc31x	140	17	.	.	.
cord-332165-31tbc31x	141	1	Similar	similar	JJ
cord-332165-31tbc31x	141	2	to	to	IN
cord-332165-31tbc31x	141	3	the	the	DT
cord-332165-31tbc31x	141	4	reovirus	reovirus	NNP
cord-332165-31tbc31x	141	5	sigma1	sigma1	NNP
cord-332165-31tbc31x	141	6	,	,	,
cord-332165-31tbc31x	141	7	the	the	DT
cord-332165-31tbc31x	141	8	adenovirus	adenovirus	NN
cord-332165-31tbc31x	141	9	fiber	fiber	NN
cord-332165-31tbc31x	141	10	has	have	VBZ
cord-332165-31tbc31x	141	11	a	a	DT
cord-332165-31tbc31x	141	12	head	head	NN
cord-332165-31tbc31x	141	13	-	-	HYPH
cord-332165-31tbc31x	141	14	and	and	CC
cord-332165-31tbc31x	141	15	-	-	HYPH
cord-332165-31tbc31x	141	16	tail	tail	NN
cord-332165-31tbc31x	141	17	morphology	morphology	NN
cord-332165-31tbc31x	141	18	and	and	CC
cord-332165-31tbc31x	141	19	features	feature	VBZ
cord-332165-31tbc31x	141	20	a	a	DT
cord-332165-31tbc31x	141	21	globular	globular	JJ
cord-332165-31tbc31x	141	22	head	head	NN
cord-332165-31tbc31x	141	23	domain	domain	NN
cord-332165-31tbc31x	141	24	(	(	-LRB-
cord-332165-31tbc31x	141	25	the	the	DT
cord-332165-31tbc31x	141	26	knob	knob	NN
cord-332165-31tbc31x	141	27	)	)	-RRB-
cord-332165-31tbc31x	141	28	that	that	IN
cord-332165-31tbc31x	141	29	projects	project	VBZ
cord-332165-31tbc31x	141	30	from	from	IN
cord-332165-31tbc31x	141	31	the	the	DT
cord-332165-31tbc31x	141	32	virus	virus	NN
cord-332165-31tbc31x	141	33	surface	surface	NN
cord-332165-31tbc31x	141	34	,	,	,
cord-332165-31tbc31x	141	35	and	and	CC
cord-332165-31tbc31x	141	36	a	a	DT
cord-332165-31tbc31x	141	37	tail	tail	NN
cord-332165-31tbc31x	141	38	(	(	-LRB-
cord-332165-31tbc31x	141	39	the	the	DT
cord-332165-31tbc31x	141	40	shaft	shaft	NN
cord-332165-31tbc31x	141	41	)	)	-RRB-
cord-332165-31tbc31x	141	42	that	that	WDT
cord-332165-31tbc31x	141	43	inserts	insert	VBZ
cord-332165-31tbc31x	141	44	into	into	IN
cord-332165-31tbc31x	141	45	the	the	DT
cord-332165-31tbc31x	141	46	virus	virus	NN
cord-332165-31tbc31x	141	47	particle	particle	NN
cord-332165-31tbc31x	141	48	[	[	-LRB-
cord-332165-31tbc31x	141	49	67	67	CD
cord-332165-31tbc31x	141	50	]	]	-RRB-
cord-332165-31tbc31x	141	51	.	.	.
cord-332165-31tbc31x	142	1	The	the	DT
cord-332165-31tbc31x	142	2	sialic	sialic	JJ
cord-332165-31tbc31x	142	3	acid	acid	NN
cord-332165-31tbc31x	142	4	binding	bind	VBG
cord-332165-31tbc31x	142	5	sites	site	NNS
cord-332165-31tbc31x	142	6	of	of	IN
cord-332165-31tbc31x	142	7	the	the	DT
cord-332165-31tbc31x	142	8	different	different	JJ
cord-332165-31tbc31x	142	9	structurally	structurally	RB
cord-332165-31tbc31x	142	10	characterized	characterize	VBN
cord-332165-31tbc31x	142	11	adenovirus	adenovirus	NN
cord-332165-31tbc31x	142	12	types	type	NNS
cord-332165-31tbc31x	142	13	are	be	VBP
cord-332165-31tbc31x	142	14	located	locate	VBN
cord-332165-31tbc31x	142	15	in	in	IN
cord-332165-31tbc31x	142	16	the	the	DT
cord-332165-31tbc31x	142	17	fiber	fiber	NN
cord-332165-31tbc31x	142	18	knob	knob	NN
cord-332165-31tbc31x	142	19	domain	domain	NN
cord-332165-31tbc31x	142	20	[	[	-LRB-
cord-332165-31tbc31x	142	21	26	26	CD
cord-332165-31tbc31x	142	22	,	,	,
cord-332165-31tbc31x	142	23	68	68	CD
cord-332165-31tbc31x	142	24	]	]	-RRB-
cord-332165-31tbc31x	142	25	.	.	.
cord-332165-31tbc31x	143	1	While	while	IN
cord-332165-31tbc31x	143	2	these	these	DT
cord-332165-31tbc31x	143	3	sites	site	NNS
cord-332165-31tbc31x	143	4	differ	differ	VBP
cord-332165-31tbc31x	143	5	in	in	IN
cord-332165-31tbc31x	143	6	location	location	NN
cord-332165-31tbc31x	143	7	in	in	IN
cord-332165-31tbc31x	143	8	different	different	JJ
cord-332165-31tbc31x	143	9	adenoviruses	adenovirus	NNS
cord-332165-31tbc31x	143	10	,	,	,
cord-332165-31tbc31x	143	11	they	-PRON-	PRP
cord-332165-31tbc31x	143	12	are	be	VBP
cord-332165-31tbc31x	143	13	all	all	RB
cord-332165-31tbc31x	143	14	linked	link	VBN
cord-332165-31tbc31x	143	15	by	by	IN
cord-332165-31tbc31x	143	16	three	three	CD
cord-332165-31tbc31x	143	17	-	-	HYPH
cord-332165-31tbc31x	143	18	fold	fold	NN
cord-332165-31tbc31x	143	19	symmetry	symmetry	NN
cord-332165-31tbc31x	143	20	and	and	CC
cord-332165-31tbc31x	143	21	lie	lie	NN
cord-332165-31tbc31x	143	22	in	in	IN
cord-332165-31tbc31x	143	23	close	close	JJ
cord-332165-31tbc31x	143	24	proximity	proximity	NN
cord-332165-31tbc31x	143	25	to	to	IN
cord-332165-31tbc31x	143	26	each	each	DT
cord-332165-31tbc31x	143	27	other	other	JJ
cord-332165-31tbc31x	143	28	(	(	-LRB-
cord-332165-31tbc31x	143	29	Figure	figure	NN
cord-332165-31tbc31x	143	30	4a	4a	CD
cord-332165-31tbc31x	143	31	,	,	,
cord-332165-31tbc31x	143	32	HAdV37	HAdV37	NNP
cord-332165-31tbc31x	143	33	and	and	CC
cord-332165-31tbc31x	143	34	HAdV52	HAdV52	NNP
cord-332165-31tbc31x	143	35	)	)	-RRB-
cord-332165-31tbc31x	143	36	.	.	.
cord-332165-31tbc31x	144	1	Although	although	IN
cord-332165-31tbc31x	144	2	this	this	DT
cord-332165-31tbc31x	144	3	review	review	NN
cord-332165-31tbc31x	144	4	focuses	focus	VBZ
cord-332165-31tbc31x	144	5	on	on	IN
cord-332165-31tbc31x	144	6	non	non	JJ
cord-332165-31tbc31x	144	7	-	-	JJ
cord-332165-31tbc31x	144	8	enveloped	enveloped	JJ
cord-332165-31tbc31x	144	9	viruses	virus	NNS
cord-332165-31tbc31x	144	10	,	,	,
cord-332165-31tbc31x	144	11	it	-PRON-	PRP
cord-332165-31tbc31x	144	12	should	should	MD
cord-332165-31tbc31x	144	13	still	still	RB
cord-332165-31tbc31x	144	14	be	be	VB
cord-332165-31tbc31x	144	15	mentioned	mention	VBN
cord-332165-31tbc31x	144	16	that	that	IN
cord-332165-31tbc31x	144	17	some	some	DT
cord-332165-31tbc31x	144	18	of	of	IN
cord-332165-31tbc31x	144	19	the	the	DT
cord-332165-31tbc31x	144	20	concepts	concept	NNS
cord-332165-31tbc31x	144	21	described	describe	VBN
cord-332165-31tbc31x	144	22	above	above	RB
cord-332165-31tbc31x	144	23	also	also	RB
cord-332165-31tbc31x	144	24	apply	apply	VBP
cord-332165-31tbc31x	144	25	to	to	IN
cord-332165-31tbc31x	144	26	enveloped	envelop	VBN
cord-332165-31tbc31x	144	27	viruses	virus	NNS
cord-332165-31tbc31x	144	28	,	,	,
cord-332165-31tbc31x	144	29	such	such	JJ
cord-332165-31tbc31x	144	30	as	as	IN
cord-332165-31tbc31x	144	31	coronaviruses	coronaviruse	NNS
cord-332165-31tbc31x	144	32	,	,	,
cord-332165-31tbc31x	144	33	paramyxoviruses	paramyxovirus	NNS
cord-332165-31tbc31x	144	34	,	,	,
cord-332165-31tbc31x	144	35	and	and	CC
cord-332165-31tbc31x	144	36	orthomyxoviruses	orthomyxovirus	NNS
cord-332165-31tbc31x	144	37	.	.	.
cord-332165-31tbc31x	145	1	While	while	IN
cord-332165-31tbc31x	145	2	global	global	JJ
cord-332165-31tbc31x	145	3	symmetry	symmetry	NN
cord-332165-31tbc31x	145	4	measures	measure	NNS
cord-332165-31tbc31x	145	5	for	for	IN
cord-332165-31tbc31x	145	6	these	these	DT
cord-332165-31tbc31x	145	7	viruses	virus	NNS
cord-332165-31tbc31x	145	8	are	be	VBP
cord-332165-31tbc31x	145	9	elusive	elusive	JJ
cord-332165-31tbc31x	145	10	(	(	-LRB-
cord-332165-31tbc31x	145	11	since	since	IN
cord-332165-31tbc31x	145	12	their	-PRON-	PRP$
cord-332165-31tbc31x	145	13	attachment	attachment	NN
cord-332165-31tbc31x	145	14	proteins	protein	NNS
cord-332165-31tbc31x	145	15	are	be	VBP
cord-332165-31tbc31x	145	16	membrane	membrane	NN
cord-332165-31tbc31x	145	17	-	-	HYPH
cord-332165-31tbc31x	145	18	bound	bind	VBN
cord-332165-31tbc31x	145	19	,	,	,
cord-332165-31tbc31x	145	20	somewhat	somewhat	RB
cord-332165-31tbc31x	145	21	mobile	mobile	JJ
cord-332165-31tbc31x	145	22	,	,	,
cord-332165-31tbc31x	145	23	and	and	CC
cord-332165-31tbc31x	145	24	do	do	VBP
cord-332165-31tbc31x	145	25	not	not	RB
cord-332165-31tbc31x	145	26	follow	follow	VB
cord-332165-31tbc31x	145	27	easily	easily	RB
cord-332165-31tbc31x	145	28	-	-	HYPH
cord-332165-31tbc31x	145	29	appreciated	appreciate	VBN
cord-332165-31tbc31x	145	30	assembly	assembly	NN
cord-332165-31tbc31x	145	31	rules	rule	NNS
cord-332165-31tbc31x	145	32	)	)	-RRB-
cord-332165-31tbc31x	145	33	,	,	,
cord-332165-31tbc31x	145	34	the	the	DT
cord-332165-31tbc31x	145	35	existing	exist	VBG
cord-332165-31tbc31x	145	36	local	local	JJ
cord-332165-31tbc31x	145	37	binding	binding	NN
cord-332165-31tbc31x	145	38	site	site	NN
cord-332165-31tbc31x	145	39	symmetries	symmetry	NNS
cord-332165-31tbc31x	145	40	within	within	IN
cord-332165-31tbc31x	145	41	multimeric	multimeric	JJ
cord-332165-31tbc31x	145	42	attachment	attachment	NN
cord-332165-31tbc31x	145	43	proteins	protein	NNS
cord-332165-31tbc31x	145	44	can	can	MD
cord-332165-31tbc31x	145	45	still	still	RB
cord-332165-31tbc31x	145	46	be	be	VB
cord-332165-31tbc31x	145	47	exploited	exploit	VBN
cord-332165-31tbc31x	145	48	for	for	IN
cord-332165-31tbc31x	145	49	rational	rational	JJ
cord-332165-31tbc31x	145	50	multivalent	multivalent	JJ
cord-332165-31tbc31x	145	51	inhibitor	inhibitor	NN
cord-332165-31tbc31x	145	52	design	design	NN
cord-332165-31tbc31x	145	53	.	.	.
cord-332165-31tbc31x	146	1	A	a	DT
cord-332165-31tbc31x	146	2	prominent	prominent	JJ
cord-332165-31tbc31x	146	3	example	example	NN
cord-332165-31tbc31x	146	4	is	be	VBZ
cord-332165-31tbc31x	146	5	the	the	DT
cord-332165-31tbc31x	146	6	influenza	influenza	NN
cord-332165-31tbc31x	146	7	A	a	DT
cord-332165-31tbc31x	146	8	virus	virus	NN
cord-332165-31tbc31x	146	9	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	146	10	,	,	,
cord-332165-31tbc31x	146	11	which	which	WDT
cord-332165-31tbc31x	146	12	is	be	VBZ
cord-332165-31tbc31x	146	13	a	a	DT
cord-332165-31tbc31x	146	14	homotrimeric	homotrimeric	JJ
cord-332165-31tbc31x	146	15	protein	protein	NN
cord-332165-31tbc31x	146	16	bearing	bear	VBG
cord-332165-31tbc31x	146	17	three	three	CD
cord-332165-31tbc31x	146	18	individual	individual	JJ
cord-332165-31tbc31x	146	19	sialic	sialic	NN
cord-332165-31tbc31x	146	20	acid	acid	NN
cord-332165-31tbc31x	146	21	binding	bind	VBG
cord-332165-31tbc31x	146	22	sites	site	NNS
cord-332165-31tbc31x	146	23	[	[	-LRB-
cord-332165-31tbc31x	146	24	69	69	CD
cord-332165-31tbc31x	146	25	]	]	-RRB-
cord-332165-31tbc31x	146	26	.	.	.
cord-332165-31tbc31x	147	1	These	these	DT
cord-332165-31tbc31x	147	2	binding	bind	VBG
cord-332165-31tbc31x	147	3	sites	site	NNS
cord-332165-31tbc31x	147	4	are	be	VBP
cord-332165-31tbc31x	147	5	related	relate	VBN
cord-332165-31tbc31x	147	6	by	by	IN
cord-332165-31tbc31x	147	7	local	local	JJ
cord-332165-31tbc31x	147	8	three	three	CD
cord-332165-31tbc31x	147	9	-	-	HYPH
cord-332165-31tbc31x	147	10	fold	fold	JJ
cord-332165-31tbc31x	147	11	rotational	rotational	JJ
cord-332165-31tbc31x	147	12	symmetry	symmetry	NN
cord-332165-31tbc31x	147	13	,	,	,
cord-332165-31tbc31x	147	14	with	with	IN
cord-332165-31tbc31x	147	15	a	a	DT
cord-332165-31tbc31x	147	16	distance	distance	NN
cord-332165-31tbc31x	147	17	of	of	IN
cord-332165-31tbc31x	147	18	2.5	2.5	CD
cord-332165-31tbc31x	147	19	nm	nm	NN
cord-332165-31tbc31x	147	20	from	from	IN
cord-332165-31tbc31x	147	21	the	the	DT
cord-332165-31tbc31x	147	22	three	three	CD
cord-332165-31tbc31x	147	23	-	-	HYPH
cord-332165-31tbc31x	147	24	fold	fold	NN
cord-332165-31tbc31x	147	25	axis	axis	NN
cord-332165-31tbc31x	147	26	(	(	-LRB-
cord-332165-31tbc31x	147	27	Figure	figure	NN
cord-332165-31tbc31x	147	28	4a	4a	CD
cord-332165-31tbc31x	147	29	,	,	,
cord-332165-31tbc31x	147	30	IAV	IAV	NNP
cord-332165-31tbc31x	147	31	)	)	-RRB-
cord-332165-31tbc31x	147	32	.	.	.
cord-332165-31tbc31x	148	1	The	the	DT
cord-332165-31tbc31x	148	2	sialic	sialic	JJ
cord-332165-31tbc31x	148	3	acid	acid	NN
cord-332165-31tbc31x	148	4	moieties	moiety	NNS
cord-332165-31tbc31x	148	5	of	of	IN
cord-332165-31tbc31x	148	6	glycosylated	glycosylated	JJ
cord-332165-31tbc31x	148	7	proteins	protein	NNS
cord-332165-31tbc31x	148	8	and/or	and/or	CC
cord-332165-31tbc31x	148	9	glycolipids	glycolipid	NNS
cord-332165-31tbc31x	148	10	are	be	VBP
cord-332165-31tbc31x	148	11	required	require	VBN
cord-332165-31tbc31x	148	12	for	for	IN
cord-332165-31tbc31x	148	13	the	the	DT
cord-332165-31tbc31x	148	14	attachment	attachment	NN
cord-332165-31tbc31x	148	15	,	,	,
cord-332165-31tbc31x	148	16	entry	entry	NN
cord-332165-31tbc31x	148	17	,	,	,
cord-332165-31tbc31x	148	18	and	and	CC
cord-332165-31tbc31x	148	19	productive	productive	JJ
cord-332165-31tbc31x	148	20	infection	infection	NN
cord-332165-31tbc31x	148	21	of	of	IN
cord-332165-31tbc31x	148	22	many	many	JJ
cord-332165-31tbc31x	148	23	viruses	virus	NNS
cord-332165-31tbc31x	148	24	.	.	.
cord-332165-31tbc31x	149	1	In	in	IN
cord-332165-31tbc31x	149	2	the	the	DT
cord-332165-31tbc31x	149	3	majority	majority	NN
cord-332165-31tbc31x	149	4	of	of	IN
cord-332165-31tbc31x	149	5	cases	case	NNS
cord-332165-31tbc31x	149	6	,	,	,
cord-332165-31tbc31x	149	7	the	the	DT
cord-332165-31tbc31x	149	8	viral	viral	JJ
cord-332165-31tbc31x	149	9	binding	binding	NN
cord-332165-31tbc31x	149	10	sites	site	NNS
cord-332165-31tbc31x	149	11	are	be	VBP
cord-332165-31tbc31x	149	12	surface	surface	NN
cord-332165-31tbc31x	149	13	-	-	HYPH
cord-332165-31tbc31x	149	14	exposed	expose	VBN
cord-332165-31tbc31x	149	15	and	and	CC
cord-332165-31tbc31x	149	16	engage	engage	VB
cord-332165-31tbc31x	149	17	terminal	terminal	JJ
cord-332165-31tbc31x	149	18	sialic	sialic	JJ
cord-332165-31tbc31x	149	19	acid	acid	NN
cord-332165-31tbc31x	149	20	residues	residue	NNS
cord-332165-31tbc31x	149	21	with	with	IN
cord-332165-31tbc31x	149	22	a	a	DT
cord-332165-31tbc31x	149	23	range	range	NN
cord-332165-31tbc31x	149	24	of	of	IN
cord-332165-31tbc31x	149	25	hydrophilic	hydrophilic	JJ
cord-332165-31tbc31x	149	26	and	and	CC
cord-332165-31tbc31x	149	27	hydrophobic	hydrophobic	JJ
cord-332165-31tbc31x	149	28	contacts	contact	NNS
cord-332165-31tbc31x	149	29	.	.	.
cord-332165-31tbc31x	150	1	The	the	DT
cord-332165-31tbc31x	150	2	available	available	JJ
cord-332165-31tbc31x	150	3	structural	structural	JJ
cord-332165-31tbc31x	150	4	data	datum	NNS
cord-332165-31tbc31x	150	5	for	for	IN
cord-332165-31tbc31x	150	6	receptor	receptor	NN
cord-332165-31tbc31x	150	7	-	-	HYPH
cord-332165-31tbc31x	150	8	ligand	ligand	NN
cord-332165-31tbc31x	150	9	interactions	interaction	NNS
cord-332165-31tbc31x	150	10	at	at	IN
cord-332165-31tbc31x	150	11	an	an	DT
cord-332165-31tbc31x	150	12	atomic	atomic	JJ
cord-332165-31tbc31x	150	13	resolution	resolution	NN
cord-332165-31tbc31x	150	14	can	can	MD
cord-332165-31tbc31x	150	15	inform	inform	VB
cord-332165-31tbc31x	150	16	the	the	DT
cord-332165-31tbc31x	150	17	synthesis	synthesis	NN
cord-332165-31tbc31x	150	18	of	of	IN
cord-332165-31tbc31x	150	19	high	high	JJ
cord-332165-31tbc31x	150	20	affinity	affinity	NN
cord-332165-31tbc31x	150	21	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	150	22	via	via	IN
cord-332165-31tbc31x	150	23	the	the	DT
cord-332165-31tbc31x	150	24	chemical	chemical	JJ
cord-332165-31tbc31x	150	25	modifications	modification	NNS
cord-332165-31tbc31x	150	26	of	of	IN
cord-332165-31tbc31x	150	27	sialic	sialic	JJ
cord-332165-31tbc31x	150	28	acids	acid	NNS
cord-332165-31tbc31x	150	29	.	.	.
cord-332165-31tbc31x	151	1	A	a	DT
cord-332165-31tbc31x	151	2	prominent	prominent	JJ
cord-332165-31tbc31x	151	3	example	example	NN
cord-332165-31tbc31x	151	4	of	of	IN
cord-332165-31tbc31x	151	5	this	this	DT
cord-332165-31tbc31x	151	6	approach	approach	NN
cord-332165-31tbc31x	151	7	is	be	VBZ
cord-332165-31tbc31x	151	8	the	the	DT
cord-332165-31tbc31x	151	9	inhibition	inhibition	NN
cord-332165-31tbc31x	151	10	of	of	IN
cord-332165-31tbc31x	151	11	influenza	influenza	NN
cord-332165-31tbc31x	151	12	virus	virus	NN
cord-332165-31tbc31x	151	13	neuraminidases	neuraminidases	NNP
cord-332165-31tbc31x	151	14	.	.	.
cord-332165-31tbc31x	152	1	These	these	DT
cord-332165-31tbc31x	152	2	enzymes	enzyme	NNS
cord-332165-31tbc31x	152	3	recognize	recognize	VBP
cord-332165-31tbc31x	152	4	and	and	CC
cord-332165-31tbc31x	152	5	hydrolyze	hydrolyze	VB
cord-332165-31tbc31x	152	6	terminal	terminal	JJ
cord-332165-31tbc31x	152	7	sialic	sialic	JJ
cord-332165-31tbc31x	152	8	acids	acid	NNS
cord-332165-31tbc31x	152	9	of	of	IN
cord-332165-31tbc31x	152	10	cell	cell	NN
cord-332165-31tbc31x	152	11	surface	surface	NN
cord-332165-31tbc31x	152	12	glycans	glycan	NNS
cord-332165-31tbc31x	152	13	and	and	CC
cord-332165-31tbc31x	152	14	are	be	VBP
cord-332165-31tbc31x	152	15	vital	vital	JJ
cord-332165-31tbc31x	152	16	for	for	IN
cord-332165-31tbc31x	152	17	the	the	DT
cord-332165-31tbc31x	152	18	release	release	NN
cord-332165-31tbc31x	152	19	of	of	IN
cord-332165-31tbc31x	152	20	viral	viral	JJ
cord-332165-31tbc31x	152	21	progeny	progeny	NN
cord-332165-31tbc31x	152	22	[	[	-LRB-
cord-332165-31tbc31x	152	23	70	70	CD
cord-332165-31tbc31x	152	24	,	,	,
cord-332165-31tbc31x	152	25	71	71	CD
cord-332165-31tbc31x	152	26	]	]	-RRB-
cord-332165-31tbc31x	152	27	.	.	.
cord-332165-31tbc31x	153	1	An	an	DT
cord-332165-31tbc31x	153	2	early	early	JJ
cord-332165-31tbc31x	153	3	non	non	JJ
cord-332165-31tbc31x	153	4	-	-	JJ
cord-332165-31tbc31x	153	5	selective	selective	JJ
cord-332165-31tbc31x	153	6	prototype	prototype	NN
cord-332165-31tbc31x	153	7	inhibitor	inhibitor	NN
cord-332165-31tbc31x	153	8	of	of	IN
cord-332165-31tbc31x	153	9	neuraminidases	neuraminidases	NNP
cord-332165-31tbc31x	153	10	was	be	VBD
cord-332165-31tbc31x	153	11	the	the	DT
cord-332165-31tbc31x	153	12	sialic	sialic	JJ
cord-332165-31tbc31x	153	13	acid	acid	NN
cord-332165-31tbc31x	153	14	derivate	derivate	NN
cord-332165-31tbc31x	153	15	2-deoxy-2,3-didehydro	2-deoxy-2,3-didehydro	NNP
cord-332165-31tbc31x	153	16	-	-	HYPH
cord-332165-31tbc31x	153	17	N	N	NNP
cord-332165-31tbc31x	153	18	-	-	HYPH
cord-332165-31tbc31x	153	19	acetylneuraminic	acetylneuraminic	NNP
cord-332165-31tbc31x	153	20	acid	acid	NN
cord-332165-31tbc31x	153	21	(	(	-LRB-
cord-332165-31tbc31x	153	22	Neu5Ac2en	Neu5Ac2en	NNP
cord-332165-31tbc31x	153	23	,	,	,
cord-332165-31tbc31x	153	24	DANA	DANA	NNP
cord-332165-31tbc31x	153	25	)	)	-RRB-
cord-332165-31tbc31x	153	26	[	[	-LRB-
cord-332165-31tbc31x	153	27	72	72	CD
cord-332165-31tbc31x	153	28	,	,	,
cord-332165-31tbc31x	153	29	73	73	CD
cord-332165-31tbc31x	153	30	]	]	-RRB-
cord-332165-31tbc31x	153	31	.	.	.
cord-332165-31tbc31x	154	1	DANA	DANA	NNP
cord-332165-31tbc31x	154	2	can	can	MD
cord-332165-31tbc31x	154	3	engage	engage	VB
cord-332165-31tbc31x	154	4	and	and	CC
cord-332165-31tbc31x	154	5	block	block	VB
cord-332165-31tbc31x	154	6	the	the	DT
cord-332165-31tbc31x	154	7	binding	bind	VBG
cord-332165-31tbc31x	154	8	sites	site	NNS
cord-332165-31tbc31x	154	9	of	of	IN
cord-332165-31tbc31x	154	10	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	154	11	of	of	IN
cord-332165-31tbc31x	154	12	both	both	DT
cord-332165-31tbc31x	154	13	ortho	ortho	NNP
cord-332165-31tbc31x	154	14	-	-	HYPH
cord-332165-31tbc31x	154	15	and	and	CC
cord-332165-31tbc31x	154	16	paramyxoviruses	paramyxovirus	NNS
cord-332165-31tbc31x	154	17	,	,	,
cord-332165-31tbc31x	154	18	thereby	thereby	RB
cord-332165-31tbc31x	154	19	suppressing	suppress	VBG
cord-332165-31tbc31x	154	20	the	the	DT
cord-332165-31tbc31x	154	21	activity	activity	NN
cord-332165-31tbc31x	154	22	of	of	IN
cord-332165-31tbc31x	154	23	these	these	DT
cord-332165-31tbc31x	154	24	enzymes	enzyme	NNS
cord-332165-31tbc31x	154	25	.	.	.
cord-332165-31tbc31x	155	1	In	in	IN
cord-332165-31tbc31x	155	2	the	the	DT
cord-332165-31tbc31x	155	3	early	early	JJ
cord-332165-31tbc31x	155	4	1990s	1990	NNS
cord-332165-31tbc31x	155	5	,	,	,
cord-332165-31tbc31x	155	6	Mark	Mark	NNP
cord-332165-31tbc31x	155	7	von	von	NNP
cord-332165-31tbc31x	155	8	Itzstein	Itzstein	NNP
cord-332165-31tbc31x	155	9	and	and	CC
cord-332165-31tbc31x	155	10	colleagues	colleague	NNS
cord-332165-31tbc31x	155	11	made	make	VBD
cord-332165-31tbc31x	155	12	substantial	substantial	JJ
cord-332165-31tbc31x	155	13	advances	advance	NNS
cord-332165-31tbc31x	155	14	towards	towards	IN
cord-332165-31tbc31x	155	15	selective	selective	JJ
cord-332165-31tbc31x	155	16	and	and	CC
cord-332165-31tbc31x	155	17	highly	highly	RB
cord-332165-31tbc31x	155	18	affine	affine	JJ
cord-332165-31tbc31x	156	1	influenza	influenza	NN
cord-332165-31tbc31x	156	2	A	a	DT
cord-332165-31tbc31x	156	3	virus	virus	NN
cord-332165-31tbc31x	156	4	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	156	5	.	.	.
cord-332165-31tbc31x	157	1	They	-PRON-	PRP
cord-332165-31tbc31x	157	2	discovered	discover	VBD
cord-332165-31tbc31x	157	3	that	that	IN
cord-332165-31tbc31x	157	4	the	the	DT
cord-332165-31tbc31x	157	5	derivatization	derivatization	NN
cord-332165-31tbc31x	157	6	of	of	IN
cord-332165-31tbc31x	157	7	the	the	DT
cord-332165-31tbc31x	157	8	4-O	4-o	CD
cord-332165-31tbc31x	157	9	-	-	HYPH
cord-332165-31tbc31x	157	10	hydroxyl	hydroxyl	NN
cord-332165-31tbc31x	157	11	group	group	NN
cord-332165-31tbc31x	157	12	of	of	IN
cord-332165-31tbc31x	157	13	DANA	DANA	NNP
cord-332165-31tbc31x	157	14	with	with	IN
cord-332165-31tbc31x	157	15	a	a	DT
cord-332165-31tbc31x	157	16	guanidine	guanidine	NN
cord-332165-31tbc31x	157	17	moiety	moiety	NN
cord-332165-31tbc31x	157	18	drastically	drastically	RB
cord-332165-31tbc31x	157	19	increases	increase	VBZ
cord-332165-31tbc31x	157	20	affinity	affinity	NN
cord-332165-31tbc31x	157	21	to	to	IN
cord-332165-31tbc31x	157	22	the	the	DT
cord-332165-31tbc31x	157	23	influenza	influenza	NN
cord-332165-31tbc31x	157	24	A	a	DT
cord-332165-31tbc31x	157	25	virus	virus	NN
cord-332165-31tbc31x	157	26	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	157	27	,	,	,
cord-332165-31tbc31x	157	28	which	which	WDT
cord-332165-31tbc31x	157	29	resulted	result	VBD
cord-332165-31tbc31x	157	30	in	in	IN
cord-332165-31tbc31x	157	31	the	the	DT
cord-332165-31tbc31x	157	32	anti	anti	JJ
cord-332165-31tbc31x	157	33	-	-	JJ
cord-332165-31tbc31x	157	34	influenza	influenza	JJ
cord-332165-31tbc31x	157	35	drug	drug	NN
cord-332165-31tbc31x	157	36	Zanamivir	Zanamivir	NNP
cord-332165-31tbc31x	157	37	[	[	-LRB-
cord-332165-31tbc31x	157	38	74	74	CD
cord-332165-31tbc31x	157	39	,	,	,
cord-332165-31tbc31x	157	40	75	75	CD
cord-332165-31tbc31x	157	41	]	]	-RRB-
cord-332165-31tbc31x	157	42	.	.	.
cord-332165-31tbc31x	158	1	Subsequently	subsequently	RB
cord-332165-31tbc31x	158	2	,	,	,
cord-332165-31tbc31x	158	3	the	the	DT
cord-332165-31tbc31x	158	4	structures	structure	NNS
cord-332165-31tbc31x	158	5	of	of	IN
cord-332165-31tbc31x	158	6	the	the	DT
cord-332165-31tbc31x	158	7	planar	planar	JJ
cord-332165-31tbc31x	158	8	sialic	sialic	JJ
cord-332165-31tbc31x	158	9	acid	acid	NN
cord-332165-31tbc31x	158	10	transition	transition	NN
cord-332165-31tbc31x	158	11	state	state	NN
cord-332165-31tbc31x	158	12	during	during	IN
cord-332165-31tbc31x	158	13	the	the	DT
cord-332165-31tbc31x	158	14	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	158	15	reaction	reaction	NN
cord-332165-31tbc31x	158	16	became	become	VBD
cord-332165-31tbc31x	158	17	available	available	JJ
cord-332165-31tbc31x	158	18	.	.	.
cord-332165-31tbc31x	159	1	The	the	DT
cord-332165-31tbc31x	159	2	analogous	analogous	JJ
cord-332165-31tbc31x	159	3	compounds	compound	NNS
cord-332165-31tbc31x	159	4	of	of	IN
cord-332165-31tbc31x	159	5	sialic	sialic	JJ
cord-332165-31tbc31x	159	6	acid	acid	NN
cord-332165-31tbc31x	159	7	's	's	POS
cord-332165-31tbc31x	159	8	transition	transition	NN
cord-332165-31tbc31x	159	9	state	state	NN
cord-332165-31tbc31x	159	10	based	base	VBN
cord-332165-31tbc31x	159	11	on	on	IN
cord-332165-31tbc31x	159	12	benzoic	benzoic	NNP
cord-332165-31tbc31x	159	13	and	and	CC
cord-332165-31tbc31x	159	14	shikimic	shikimic	JJ
cord-332165-31tbc31x	159	15	acids	acid	NNS
cord-332165-31tbc31x	159	16	,	,	,
cord-332165-31tbc31x	159	17	and	and	CC
cord-332165-31tbc31x	159	18	subsequently	subsequently	RB
cord-332165-31tbc31x	159	19	the	the	DT
cord-332165-31tbc31x	159	20	drug	drug	NN
cord-332165-31tbc31x	159	21	Oseltamivir	Oseltamivir	NNP
cord-332165-31tbc31x	159	22	[	[	-LRB-
cord-332165-31tbc31x	159	23	76	76	CD
cord-332165-31tbc31x	159	24	]	]	-RRB-
cord-332165-31tbc31x	159	25	[	[	-LRB-
cord-332165-31tbc31x	159	26	77	77	CD
cord-332165-31tbc31x	159	27	]	]	-RRB-
cord-332165-31tbc31x	159	28	[	[	-LRB-
cord-332165-31tbc31x	159	29	78	78	CD
cord-332165-31tbc31x	159	30	]	]	-RRB-
cord-332165-31tbc31x	159	31	[	[	-LRB-
cord-332165-31tbc31x	159	32	79	79	CD
cord-332165-31tbc31x	159	33	]	]	-RRB-
cord-332165-31tbc31x	159	34	,	,	,
cord-332165-31tbc31x	159	35	benefit	benefit	VBP
cord-332165-31tbc31x	159	36	from	from	IN
cord-332165-31tbc31x	159	37	the	the	DT
cord-332165-31tbc31x	159	38	increased	increase	VBN
cord-332165-31tbc31x	159	39	affinity	affinity	NN
cord-332165-31tbc31x	159	40	to	to	IN
cord-332165-31tbc31x	159	41	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	159	42	compared	compare	VBN
cord-332165-31tbc31x	159	43	to	to	IN
cord-332165-31tbc31x	159	44	the	the	DT
cord-332165-31tbc31x	159	45	native	native	JJ
cord-332165-31tbc31x	159	46	Neu5Ac	Neu5Ac	NNP
cord-332165-31tbc31x	159	47	structure	structure	NN
cord-332165-31tbc31x	159	48	[	[	-LRB-
cord-332165-31tbc31x	159	49	80	80	CD
cord-332165-31tbc31x	159	50	,	,	,
cord-332165-31tbc31x	159	51	81	81	CD
cord-332165-31tbc31x	159	52	]	]	-RRB-
cord-332165-31tbc31x	159	53	.	.	.
cord-332165-31tbc31x	160	1	Unfortunately	unfortunately	RB
cord-332165-31tbc31x	160	2	,	,	,
cord-332165-31tbc31x	160	3	the	the	DT
cord-332165-31tbc31x	160	4	family	family	NN
cord-332165-31tbc31x	160	5	of	of	IN
cord-332165-31tbc31x	160	6	compounds	compound	NNS
cord-332165-31tbc31x	160	7	related	relate	VBN
cord-332165-31tbc31x	160	8	to	to	IN
cord-332165-31tbc31x	160	9	Zanamivir	Zanamivir	NNP
cord-332165-31tbc31x	160	10	or	or	CC
cord-332165-31tbc31x	160	11	Oseltamivir	Oseltamivir	NNP
cord-332165-31tbc31x	160	12	do	do	VBP
cord-332165-31tbc31x	160	13	not	not	RB
cord-332165-31tbc31x	160	14	act	act	VB
cord-332165-31tbc31x	160	15	against	against	IN
cord-332165-31tbc31x	160	16	viruses	virus	NNS
cord-332165-31tbc31x	160	17	that	that	WDT
cord-332165-31tbc31x	160	18	do	do	VBP
cord-332165-31tbc31x	160	19	not	not	RB
cord-332165-31tbc31x	160	20	possess	possess	VB
cord-332165-31tbc31x	160	21	neuraminidase	neuraminidase	JJ
cord-332165-31tbc31x	160	22	activity	activity	NN
cord-332165-31tbc31x	160	23	but	but	CC
cord-332165-31tbc31x	160	24	instead	instead	RB
cord-332165-31tbc31x	160	25	engage	engage	VB
cord-332165-31tbc31x	160	26	undistorted	undistorted	JJ
cord-332165-31tbc31x	160	27	sialic	sialic	JJ
cord-332165-31tbc31x	160	28	acids	acid	NNS
cord-332165-31tbc31x	160	29	via	via	IN
cord-332165-31tbc31x	160	30	a	a	DT
cord-332165-31tbc31x	160	31	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	160	32	(	(	-LRB-
cord-332165-31tbc31x	160	33	e.g.	e.g.	RB
cord-332165-31tbc31x	160	34	,	,	,
cord-332165-31tbc31x	160	35	many	many	JJ
cord-332165-31tbc31x	160	36	non	non	AFX
cord-332165-31tbc31x	160	37	-	-	JJ
cord-332165-31tbc31x	160	38	enveloped	enveloped	JJ
cord-332165-31tbc31x	160	39	viruses	virus	NNS
cord-332165-31tbc31x	160	40	discussed	discuss	VBN
cord-332165-31tbc31x	160	41	in	in	IN
cord-332165-31tbc31x	160	42	chapter	chapter	NN
cord-332165-31tbc31x	160	43	2	2	CD
cord-332165-31tbc31x	160	44	of	of	IN
cord-332165-31tbc31x	160	45	this	this	DT
cord-332165-31tbc31x	160	46	review	review	NN
cord-332165-31tbc31x	160	47	)	)	-RRB-
cord-332165-31tbc31x	160	48	.	.	.
cord-332165-31tbc31x	161	1	In	in	IN
cord-332165-31tbc31x	161	2	cases	case	NNS
cord-332165-31tbc31x	161	3	where	where	WRB
cord-332165-31tbc31x	161	4	affinities	affinity	NNS
cord-332165-31tbc31x	161	5	between	between	IN
cord-332165-31tbc31x	161	6	sialylated	sialylated	JJ
cord-332165-31tbc31x	161	7	glycans	glycan	NNS
cord-332165-31tbc31x	161	8	and	and	CC
cord-332165-31tbc31x	161	9	hemagglutinins	hemagglutinin	NNS
cord-332165-31tbc31x	161	10	have	have	VBP
cord-332165-31tbc31x	161	11	been	be	VBN
cord-332165-31tbc31x	161	12	measured	measure	VBN
cord-332165-31tbc31x	161	13	,	,	,
cord-332165-31tbc31x	161	14	the	the	DT
cord-332165-31tbc31x	161	15	interactions	interaction	NNS
cord-332165-31tbc31x	161	16	were	be	VBD
cord-332165-31tbc31x	161	17	shown	show	VBN
cord-332165-31tbc31x	161	18	to	to	TO
cord-332165-31tbc31x	161	19	have	have	VB
cord-332165-31tbc31x	161	20	dissociation	dissociation	NN
cord-332165-31tbc31x	161	21	constants	constant	NNS
cord-332165-31tbc31x	161	22	in	in	IN
cord-332165-31tbc31x	161	23	the	the	DT
cord-332165-31tbc31x	161	24	millimolar	millimolar	JJ
cord-332165-31tbc31x	161	25	range	range	NN
cord-332165-31tbc31x	161	26	[	[	-LRB-
cord-332165-31tbc31x	161	27	27	27	CD
cord-332165-31tbc31x	161	28	]	]	-RRB-
cord-332165-31tbc31x	162	1	[	[	-LRB-
cord-332165-31tbc31x	162	2	28	28	CD
cord-332165-31tbc31x	162	3	]	]	-RRB-
cord-332165-31tbc31x	163	1	[	[	-LRB-
cord-332165-31tbc31x	163	2	29	29	CD
cord-332165-31tbc31x	163	3	]	]	-RRB-
cord-332165-31tbc31x	163	4	[	[	-LRB-
cord-332165-31tbc31x	163	5	30	30	CD
cord-332165-31tbc31x	163	6	]	]	-RRB-
cord-332165-31tbc31x	163	7	.	.	.
cord-332165-31tbc31x	164	1	The	the	DT
cord-332165-31tbc31x	164	2	firm	firm	JJ
cord-332165-31tbc31x	164	3	cell	cell	NN
cord-332165-31tbc31x	164	4	attachment	attachment	NN
cord-332165-31tbc31x	164	5	of	of	IN
cord-332165-31tbc31x	164	6	these	these	DT
cord-332165-31tbc31x	164	7	viruses	virus	NNS
cord-332165-31tbc31x	164	8	is	be	VBZ
cord-332165-31tbc31x	164	9	usually	usually	RB
cord-332165-31tbc31x	164	10	driven	drive	VBN
cord-332165-31tbc31x	164	11	by	by	IN
cord-332165-31tbc31x	164	12	high	high	JJ
cord-332165-31tbc31x	164	13	avidity	avidity	NN
cord-332165-31tbc31x	164	14	,	,	,
cord-332165-31tbc31x	164	15	relying	rely	VBG
cord-332165-31tbc31x	164	16	on	on	IN
cord-332165-31tbc31x	164	17	a	a	DT
cord-332165-31tbc31x	164	18	large	large	JJ
cord-332165-31tbc31x	164	19	number	number	NN
cord-332165-31tbc31x	164	20	of	of	IN
cord-332165-31tbc31x	164	21	identical	identical	JJ
cord-332165-31tbc31x	164	22	binding	bind	VBG
cord-332165-31tbc31x	164	23	sites	site	NNS
cord-332165-31tbc31x	164	24	that	that	WDT
cord-332165-31tbc31x	164	25	can	can	MD
cord-332165-31tbc31x	164	26	engage	engage	VB
cord-332165-31tbc31x	164	27	receptors	receptor	NNS
cord-332165-31tbc31x	164	28	.	.	.
cord-332165-31tbc31x	165	1	In	in	IN
cord-332165-31tbc31x	165	2	terms	term	NNS
cord-332165-31tbc31x	165	3	of	of	IN
cord-332165-31tbc31x	165	4	the	the	DT
cord-332165-31tbc31x	165	5	inhibition	inhibition	NN
cord-332165-31tbc31x	165	6	of	of	IN
cord-332165-31tbc31x	165	7	attachment	attachment	NN
cord-332165-31tbc31x	165	8	,	,	,
cord-332165-31tbc31x	165	9	monovalent	monovalent	JJ
cord-332165-31tbc31x	165	10	sialic	sialic	NN
cord-332165-31tbc31x	165	11	acid	acid	NN
cord-332165-31tbc31x	165	12	analogues	analogue	NNS
cord-332165-31tbc31x	165	13	are	be	VBP
cord-332165-31tbc31x	165	14	generally	generally	RB
cord-332165-31tbc31x	165	15	poor	poor	JJ
cord-332165-31tbc31x	165	16	choices	choice	NNS
cord-332165-31tbc31x	165	17	,	,	,
cord-332165-31tbc31x	165	18	as	as	IN
cord-332165-31tbc31x	165	19	they	-PRON-	PRP
cord-332165-31tbc31x	165	20	are	be	VBP
cord-332165-31tbc31x	165	21	not	not	RB
cord-332165-31tbc31x	165	22	able	able	JJ
cord-332165-31tbc31x	165	23	to	to	TO
cord-332165-31tbc31x	165	24	engage	engage	VB
cord-332165-31tbc31x	165	25	a	a	DT
cord-332165-31tbc31x	165	26	single	single	JJ
cord-332165-31tbc31x	165	27	binding	binding	NN
cord-332165-31tbc31x	165	28	site	site	NN
cord-332165-31tbc31x	165	29	in	in	IN
cord-332165-31tbc31x	165	30	a	a	DT
cord-332165-31tbc31x	165	31	viral	viral	JJ
cord-332165-31tbc31x	165	32	attachment	attachment	NN
cord-332165-31tbc31x	165	33	protein	protein	NN
cord-332165-31tbc31x	165	34	with	with	IN
cord-332165-31tbc31x	165	35	high	high	JJ
cord-332165-31tbc31x	165	36	affinity	affinity	NN
cord-332165-31tbc31x	165	37	.	.	.
cord-332165-31tbc31x	166	1	Therefore	therefore	RB
cord-332165-31tbc31x	166	2	,	,	,
cord-332165-31tbc31x	166	3	polyvalent	polyvalent	JJ
cord-332165-31tbc31x	166	4	sialic	sialic	NN
cord-332165-31tbc31x	166	5	acid	acid	NN
cord-332165-31tbc31x	166	6	-	-	HYPH
cord-332165-31tbc31x	166	7	based	base	VBN
cord-332165-31tbc31x	166	8	compounds	compound	NNS
cord-332165-31tbc31x	166	9	can	can	MD
cord-332165-31tbc31x	166	10	sometimes	sometimes	RB
cord-332165-31tbc31x	166	11	be	be	VB
cord-332165-31tbc31x	166	12	more	more	RBR
cord-332165-31tbc31x	166	13	effective	effective	JJ
cord-332165-31tbc31x	166	14	.	.	.
cord-332165-31tbc31x	167	1	In	in	IN
cord-332165-31tbc31x	167	2	parallel	parallel	NN
cord-332165-31tbc31x	167	3	to	to	IN
cord-332165-31tbc31x	167	4	the	the	DT
cord-332165-31tbc31x	167	5	development	development	NN
cord-332165-31tbc31x	167	6	of	of	IN
cord-332165-31tbc31x	167	7	monovalent	monovalent	JJ
cord-332165-31tbc31x	167	8	sialic	sialic	NN
cord-332165-31tbc31x	167	9	acid	acid	NN
cord-332165-31tbc31x	167	10	transition	transition	NN
cord-332165-31tbc31x	167	11	state	state	NN
cord-332165-31tbc31x	167	12	analogues	analogue	NNS
cord-332165-31tbc31x	167	13	against	against	IN
cord-332165-31tbc31x	167	14	the	the	DT
cord-332165-31tbc31x	167	15	influenza	influenza	NN
cord-332165-31tbc31x	167	16	virus	virus	NN
cord-332165-31tbc31x	167	17	neuraminidases	neuraminidases	NNP
cord-332165-31tbc31x	167	18	,	,	,
cord-332165-31tbc31x	167	19	polymeric	polymeric	JJ
cord-332165-31tbc31x	167	20	or	or	CC
cord-332165-31tbc31x	167	21	nanoparticle	nanoparticle	NN
cord-332165-31tbc31x	167	22	based	base	VBN
cord-332165-31tbc31x	167	23	sialic	sialic	JJ
cord-332165-31tbc31x	167	24	acid	acid	NN
cord-332165-31tbc31x	167	25	conjugates	conjugate	NNS
cord-332165-31tbc31x	167	26	were	be	VBD
cord-332165-31tbc31x	167	27	developed	develop	VBN
cord-332165-31tbc31x	167	28	to	to	TO
cord-332165-31tbc31x	167	29	also	also	RB
cord-332165-31tbc31x	167	30	prohibit	prohibit	VB
cord-332165-31tbc31x	167	31	influenza	influenza	NN
cord-332165-31tbc31x	167	32	virus	virus	NN
cord-332165-31tbc31x	167	33	infection	infection	NN
cord-332165-31tbc31x	167	34	by	by	IN
cord-332165-31tbc31x	167	35	extensive	extensive	JJ
cord-332165-31tbc31x	167	36	binding	binding	NN
cord-332165-31tbc31x	167	37	to	to	IN
cord-332165-31tbc31x	167	38	the	the	DT
cord-332165-31tbc31x	167	39	viral	viral	JJ
cord-332165-31tbc31x	167	40	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	167	41	,	,	,
cord-332165-31tbc31x	167	42	thereby	thereby	RB
cord-332165-31tbc31x	167	43	shielding	shield	VBG
cord-332165-31tbc31x	167	44	the	the	DT
cord-332165-31tbc31x	167	45	virus	virus	NN
cord-332165-31tbc31x	167	46	particle	particle	NN
cord-332165-31tbc31x	167	47	.	.	.
cord-332165-31tbc31x	168	1	The	the	DT
cord-332165-31tbc31x	168	2	influenza	influenza	NN
cord-332165-31tbc31x	168	3	virus	virus	NN
cord-332165-31tbc31x	168	4	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	168	5	can	can	MD
cord-332165-31tbc31x	168	6	be	be	VB
cord-332165-31tbc31x	168	7	blocked	block	VBN
cord-332165-31tbc31x	168	8	by	by	IN
cord-332165-31tbc31x	168	9	multivalent	multivalent	JJ
cord-332165-31tbc31x	168	10	sialosides	sialoside	NNS
cord-332165-31tbc31x	168	11	that	that	WDT
cord-332165-31tbc31x	168	12	vary	vary	VBP
cord-332165-31tbc31x	168	13	in	in	IN
cord-332165-31tbc31x	168	14	chemical	chemical	JJ
cord-332165-31tbc31x	168	15	composition	composition	NN
cord-332165-31tbc31x	168	16	,	,	,
cord-332165-31tbc31x	168	17	size	size	NN
cord-332165-31tbc31x	168	18	,	,	,
cord-332165-31tbc31x	168	19	branching	branch	VBG
cord-332165-31tbc31x	168	20	complexity	complexity	NN
cord-332165-31tbc31x	168	21	,	,	,
cord-332165-31tbc31x	168	22	and	and	CC
cord-332165-31tbc31x	168	23	ligand	ligand	NN
cord-332165-31tbc31x	168	24	density	density	NN
cord-332165-31tbc31x	168	25	[	[	-LRB-
cord-332165-31tbc31x	168	26	82	82	CD
cord-332165-31tbc31x	168	27	]	]	-RRB-
cord-332165-31tbc31x	169	1	[	[	-LRB-
cord-332165-31tbc31x	169	2	83	83	CD
cord-332165-31tbc31x	169	3	]	]	-RRB-
cord-332165-31tbc31x	170	1	[	[	-LRB-
cord-332165-31tbc31x	170	2	84	84	CD
cord-332165-31tbc31x	170	3	]	]	-RRB-
cord-332165-31tbc31x	170	4	[	[	-LRB-
cord-332165-31tbc31x	170	5	85	85	CD
cord-332165-31tbc31x	170	6	]	]	-RRB-
cord-332165-31tbc31x	170	7	[	[	-LRB-
cord-332165-31tbc31x	170	8	86	86	CD
cord-332165-31tbc31x	170	9	]	]	-RRB-
cord-332165-31tbc31x	170	10	.	.	.
cord-332165-31tbc31x	171	1	Particularly	particularly	RB
cord-332165-31tbc31x	171	2	the	the	DT
cord-332165-31tbc31x	171	3	effects	effect	NNS
cord-332165-31tbc31x	171	4	of	of	IN
cord-332165-31tbc31x	171	5	the	the	DT
cord-332165-31tbc31x	171	6	nature	nature	NN
cord-332165-31tbc31x	171	7	of	of	IN
cord-332165-31tbc31x	171	8	the	the	DT
cord-332165-31tbc31x	171	9	scaffold	scaffold	NN
cord-332165-31tbc31x	171	10	(	(	-LRB-
cord-332165-31tbc31x	171	11	or	or	CC
cord-332165-31tbc31x	171	12	platform	platform	NN
cord-332165-31tbc31x	171	13	)	)	-RRB-
cord-332165-31tbc31x	171	14	and	and	CC
cord-332165-31tbc31x	171	15	spatial	spatial	JJ
cord-332165-31tbc31x	171	16	sialic	sialic	JJ
cord-332165-31tbc31x	171	17	acid	acid	NN
cord-332165-31tbc31x	171	18	distribution	distribution	NN
cord-332165-31tbc31x	171	19	in	in	IN
cord-332165-31tbc31x	171	20	polyvalent	polyvalent	JJ
cord-332165-31tbc31x	171	21	viral	viral	JJ
cord-332165-31tbc31x	171	22	attachment	attachment	NN
cord-332165-31tbc31x	171	23	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	171	24	are	be	VBP
cord-332165-31tbc31x	171	25	still	still	RB
cord-332165-31tbc31x	171	26	being	be	VBG
cord-332165-31tbc31x	171	27	investigated	investigate	VBN
cord-332165-31tbc31x	171	28	[	[	-LRB-
cord-332165-31tbc31x	171	29	87	87	CD
cord-332165-31tbc31x	171	30	]	]	-RRB-
cord-332165-31tbc31x	171	31	.	.	.
cord-332165-31tbc31x	172	1	Recently	recently	RB
cord-332165-31tbc31x	172	2	,	,	,
cord-332165-31tbc31x	172	3	excellent	excellent	JJ
cord-332165-31tbc31x	172	4	reviews	review	NNS
cord-332165-31tbc31x	172	5	covering	cover	VBG
cord-332165-31tbc31x	172	6	the	the	DT
cord-332165-31tbc31x	172	7	composition	composition	NN
cord-332165-31tbc31x	172	8	and	and	CC
cord-332165-31tbc31x	172	9	biophysical	biophysical	JJ
cord-332165-31tbc31x	172	10	properties	property	NNS
cord-332165-31tbc31x	172	11	of	of	IN
cord-332165-31tbc31x	172	12	multivalent	multivalent	JJ
cord-332165-31tbc31x	172	13	sialosides	sialoside	NNS
cord-332165-31tbc31x	172	14	were	be	VBD
cord-332165-31tbc31x	172	15	published	publish	VBN
cord-332165-31tbc31x	172	16	by	by	IN
cord-332165-31tbc31x	172	17	Bhatia	Bhatia	NNP
cord-332165-31tbc31x	172	18	et	et	NNP
cord-332165-31tbc31x	172	19	al	al	NNP
cord-332165-31tbc31x	172	20	.	.	.
cord-332165-31tbc31x	173	1	[	[	-LRB-
cord-332165-31tbc31x	173	2	88	88	CD
cord-332165-31tbc31x	173	3	]	]	-RRB-
cord-332165-31tbc31x	173	4	and	and	CC
cord-332165-31tbc31x	173	5	Lu	Lu	NNP
cord-332165-31tbc31x	173	6	et	et	FW
cord-332165-31tbc31x	173	7	al	al	NNP
cord-332165-31tbc31x	173	8	.	.	.
cord-332165-31tbc31x	174	1	[	[	-LRB-
cord-332165-31tbc31x	174	2	89	89	CD
cord-332165-31tbc31x	174	3	]	]	-RRB-
cord-332165-31tbc31x	174	4	,	,	,
cord-332165-31tbc31x	174	5	so	so	IN
cord-332165-31tbc31x	174	6	we	-PRON-	PRP
cord-332165-31tbc31x	174	7	will	will	MD
cord-332165-31tbc31x	174	8	not	not	RB
cord-332165-31tbc31x	174	9	discuss	discuss	VB
cord-332165-31tbc31x	174	10	this	this	DT
cord-332165-31tbc31x	174	11	topic	topic	NN
cord-332165-31tbc31x	174	12	further	further	RB
cord-332165-31tbc31x	174	13	here	here	RB
cord-332165-31tbc31x	174	14	.	.	.
cord-332165-31tbc31x	175	1	Next	next	RB
cord-332165-31tbc31x	175	2	to	to	IN
cord-332165-31tbc31x	175	3	the	the	DT
cord-332165-31tbc31x	175	4	design	design	NN
cord-332165-31tbc31x	175	5	of	of	IN
cord-332165-31tbc31x	175	6	monovalent	monovalent	NN
cord-332165-31tbc31x	175	7	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	175	8	or	or	CC
cord-332165-31tbc31x	175	9	highly	highly	RB
cord-332165-31tbc31x	175	10	complex	complex	JJ
cord-332165-31tbc31x	175	11	polyvalent	polyvalent	JJ
cord-332165-31tbc31x	175	12	macromolecular	macromolecular	JJ
cord-332165-31tbc31x	175	13	structures	structure	NNS
cord-332165-31tbc31x	175	14	,	,	,
cord-332165-31tbc31x	175	15	a	a	DT
cord-332165-31tbc31x	175	16	third	third	JJ
cord-332165-31tbc31x	175	17	and	and	CC
cord-332165-31tbc31x	175	18	rather	rather	RB
cord-332165-31tbc31x	175	19	minimalistic	minimalistic	JJ
cord-332165-31tbc31x	175	20	design	design	NN
cord-332165-31tbc31x	175	21	strategy	strategy	NN
cord-332165-31tbc31x	175	22	makes	make	VBZ
cord-332165-31tbc31x	175	23	use	use	NN
cord-332165-31tbc31x	175	24	of	of	IN
cord-332165-31tbc31x	175	25	the	the	DT
cord-332165-31tbc31x	175	26	internal	internal	JJ
cord-332165-31tbc31x	175	27	symmetry	symmetry	NN
cord-332165-31tbc31x	175	28	of	of	IN
cord-332165-31tbc31x	175	29	the	the	DT
cord-332165-31tbc31x	175	30	addressed	address	VBN
cord-332165-31tbc31x	175	31	targets	target	NNS
cord-332165-31tbc31x	175	32	.	.	.
cord-332165-31tbc31x	176	1	As	as	IN
cord-332165-31tbc31x	176	2	elucidated	elucidate	VBN
cord-332165-31tbc31x	176	3	earlier	early	RBR
cord-332165-31tbc31x	176	4	in	in	IN
cord-332165-31tbc31x	176	5	this	this	DT
cord-332165-31tbc31x	176	6	review	review	NN
cord-332165-31tbc31x	176	7	,	,	,
cord-332165-31tbc31x	176	8	many	many	JJ
cord-332165-31tbc31x	176	9	viral	viral	JJ
cord-332165-31tbc31x	176	10	attachment	attachment	NN
cord-332165-31tbc31x	176	11	proteins	protein	NNS
cord-332165-31tbc31x	176	12	employ	employ	VBP
cord-332165-31tbc31x	176	13	a	a	DT
cord-332165-31tbc31x	176	14	local	local	JJ
cord-332165-31tbc31x	176	15	symmetry	symmetry	NN
cord-332165-31tbc31x	176	16	of	of	IN
cord-332165-31tbc31x	176	17	their	-PRON-	PRP$
cord-332165-31tbc31x	176	18	receptor	receptor	NN
cord-332165-31tbc31x	176	19	binding	bind	VBG
cord-332165-31tbc31x	176	20	sites	site	NNS
cord-332165-31tbc31x	176	21	that	that	WDT
cord-332165-31tbc31x	176	22	represent	represent	VBP
cord-332165-31tbc31x	176	23	a	a	DT
cord-332165-31tbc31x	176	24	convenient	convenient	JJ
cord-332165-31tbc31x	176	25	framework	framework	NN
cord-332165-31tbc31x	176	26	for	for	IN
cord-332165-31tbc31x	176	27	the	the	DT
cord-332165-31tbc31x	176	28	rational	rational	JJ
cord-332165-31tbc31x	176	29	design	design	NN
cord-332165-31tbc31x	176	30	of	of	IN
cord-332165-31tbc31x	176	31	small	small	JJ
cord-332165-31tbc31x	176	32	,	,	,
cord-332165-31tbc31x	176	33	tailored	tailor	VBN
cord-332165-31tbc31x	176	34	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	176	35	.	.	.
cord-332165-31tbc31x	177	1	In	in	IN
cord-332165-31tbc31x	177	2	contrast	contrast	NN
cord-332165-31tbc31x	177	3	to	to	IN
cord-332165-31tbc31x	177	4	monovalent	monovalent	NNP
cord-332165-31tbc31x	177	5	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	177	6	,	,	,
cord-332165-31tbc31x	177	7	oligovalent	oligovalent	JJ
cord-332165-31tbc31x	177	8	compounds	compound	NNS
cord-332165-31tbc31x	177	9	can	can	MD
cord-332165-31tbc31x	177	10	benefit	benefit	VB
cord-332165-31tbc31x	177	11	from	from	IN
cord-332165-31tbc31x	177	12	cooperative	cooperative	JJ
cord-332165-31tbc31x	177	13	binding	binding	NN
cord-332165-31tbc31x	177	14	or	or	CC
cord-332165-31tbc31x	177	15	avidity	avidity	NN
cord-332165-31tbc31x	177	16	.	.	.
cord-332165-31tbc31x	178	1	Nevertheless	nevertheless	RB
cord-332165-31tbc31x	178	2	,	,	,
cord-332165-31tbc31x	178	3	they	-PRON-	PRP
cord-332165-31tbc31x	178	4	are	be	VBP
cord-332165-31tbc31x	178	5	small	small	JJ
cord-332165-31tbc31x	178	6	enough	enough	RB
cord-332165-31tbc31x	178	7	for	for	IN
cord-332165-31tbc31x	178	8	nephric	nephric	NNP
cord-332165-31tbc31x	178	9	clearance	clearance	NN
cord-332165-31tbc31x	178	10	and	and	CC
cord-332165-31tbc31x	178	11	display	display	VB
cord-332165-31tbc31x	178	12	a	a	DT
cord-332165-31tbc31x	178	13	higher	high	JJR
cord-332165-31tbc31x	178	14	bioavailability	bioavailability	NN
cord-332165-31tbc31x	178	15	than	than	IN
cord-332165-31tbc31x	178	16	most	most	JJS
cord-332165-31tbc31x	178	17	macromolecular	macromolecular	JJ
cord-332165-31tbc31x	178	18	polyvalent	polyvalent	JJ
cord-332165-31tbc31x	178	19	structures	structure	NNS
cord-332165-31tbc31x	178	20	[	[	-LRB-
cord-332165-31tbc31x	178	21	90	90	CD
cord-332165-31tbc31x	178	22	]	]	-RRB-
cord-332165-31tbc31x	178	23	.	.	.
cord-332165-31tbc31x	179	1	The	the	DT
cord-332165-31tbc31x	179	2	design	design	NN
cord-332165-31tbc31x	179	3	of	of	IN
cord-332165-31tbc31x	179	4	oligovalent	oligovalent	JJ
cord-332165-31tbc31x	179	5	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	179	6	is	be	VBZ
cord-332165-31tbc31x	179	7	usually	usually	RB
cord-332165-31tbc31x	179	8	based	base	VBN
cord-332165-31tbc31x	179	9	on	on	IN
cord-332165-31tbc31x	179	10	available	available	JJ
cord-332165-31tbc31x	179	11	crystal	crystal	NN
cord-332165-31tbc31x	179	12	structures	structure	NNS
cord-332165-31tbc31x	179	13	,	,	,
cord-332165-31tbc31x	179	14	taking	take	VBG
cord-332165-31tbc31x	179	15	the	the	DT
cord-332165-31tbc31x	179	16	symmetry	symmetry	NN
cord-332165-31tbc31x	179	17	and	and	CC
cord-332165-31tbc31x	179	18	topology	topology	NN
cord-332165-31tbc31x	179	19	of	of	IN
cord-332165-31tbc31x	179	20	the	the	DT
cord-332165-31tbc31x	179	21	target	target	NN
cord-332165-31tbc31x	179	22	into	into	IN
cord-332165-31tbc31x	179	23	account	account	NN
cord-332165-31tbc31x	179	24	.	.	.
cord-332165-31tbc31x	180	1	The	the	DT
cord-332165-31tbc31x	180	2	accessibility	accessibility	NN
cord-332165-31tbc31x	180	3	of	of	IN
cord-332165-31tbc31x	180	4	the	the	DT
cord-332165-31tbc31x	180	5	individual	individual	JJ
cord-332165-31tbc31x	180	6	ligand	ligand	NN
cord-332165-31tbc31x	180	7	binding	bind	VBG
cord-332165-31tbc31x	180	8	sites	site	NNS
cord-332165-31tbc31x	180	9	and	and	CC
cord-332165-31tbc31x	180	10	their	-PRON-	PRP$
cord-332165-31tbc31x	180	11	distances	distance	NNS
cord-332165-31tbc31x	180	12	from	from	IN
cord-332165-31tbc31x	180	13	an	an	DT
cord-332165-31tbc31x	180	14	eventual	eventual	JJ
cord-332165-31tbc31x	180	15	symmetry	symmetry	NN
cord-332165-31tbc31x	180	16	axis	axis	NN
cord-332165-31tbc31x	180	17	should	should	MD
cord-332165-31tbc31x	180	18	be	be	VB
cord-332165-31tbc31x	180	19	considered	consider	VBN
cord-332165-31tbc31x	180	20	.	.	.
cord-332165-31tbc31x	181	1	For	for	IN
cord-332165-31tbc31x	181	2	binding	bind	VBG
cord-332165-31tbc31x	181	3	sites	site	NNS
cord-332165-31tbc31x	181	4	in	in	IN
cord-332165-31tbc31x	181	5	close	close	JJ
cord-332165-31tbc31x	181	6	proximity	proximity	NN
cord-332165-31tbc31x	181	7	to	to	IN
cord-332165-31tbc31x	181	8	the	the	DT
cord-332165-31tbc31x	181	9	local	local	JJ
cord-332165-31tbc31x	181	10	symmetry	symmetry	NN
cord-332165-31tbc31x	181	11	axis	axis	NN
cord-332165-31tbc31x	181	12	,	,	,
cord-332165-31tbc31x	181	13	it	-PRON-	PRP
cord-332165-31tbc31x	181	14	can	can	MD
cord-332165-31tbc31x	181	15	be	be	VB
cord-332165-31tbc31x	181	16	feasible	feasible	JJ
cord-332165-31tbc31x	181	17	to	to	TO
cord-332165-31tbc31x	181	18	start	start	VB
cord-332165-31tbc31x	181	19	from	from	IN
cord-332165-31tbc31x	181	20	a	a	DT
cord-332165-31tbc31x	181	21	central	central	JJ
cord-332165-31tbc31x	181	22	molecule	molecule	NN
cord-332165-31tbc31x	181	23	,	,	,
cord-332165-31tbc31x	181	24	which	which	WDT
cord-332165-31tbc31x	181	25	can	can	MD
cord-332165-31tbc31x	181	26	be	be	VB
cord-332165-31tbc31x	181	27	derivatized	derivatize	VBN
cord-332165-31tbc31x	181	28	by	by	IN
cord-332165-31tbc31x	181	29	ligand	ligand	NN
cord-332165-31tbc31x	181	30	terminating	terminate	VBG
cord-332165-31tbc31x	181	31	linkers	linker	NNS
cord-332165-31tbc31x	181	32	,	,	,
cord-332165-31tbc31x	181	33	resulting	result	VBG
cord-332165-31tbc31x	181	34	in	in	IN
cord-332165-31tbc31x	181	35	an	an	DT
cord-332165-31tbc31x	181	36	inhibitor	inhibitor	NN
cord-332165-31tbc31x	181	37	with	with	IN
cord-332165-31tbc31x	181	38	a	a	DT
cord-332165-31tbc31x	181	39	radial	radial	JJ
cord-332165-31tbc31x	181	40	structure	structure	NN
cord-332165-31tbc31x	181	41	.	.	.
cord-332165-31tbc31x	182	1	For	for	IN
cord-332165-31tbc31x	182	2	binding	bind	VBG
cord-332165-31tbc31x	182	3	sites	site	NNS
cord-332165-31tbc31x	182	4	that	that	WDT
cord-332165-31tbc31x	182	5	are	be	VBP
cord-332165-31tbc31x	182	6	far	far	RB
cord-332165-31tbc31x	182	7	from	from	IN
cord-332165-31tbc31x	182	8	the	the	DT
cord-332165-31tbc31x	182	9	local	local	JJ
cord-332165-31tbc31x	182	10	symmetry	symmetry	NN
cord-332165-31tbc31x	182	11	axis	axis	NN
cord-332165-31tbc31x	182	12	or	or	CC
cord-332165-31tbc31x	182	13	in	in	IN
cord-332165-31tbc31x	182	14	a	a	DT
cord-332165-31tbc31x	182	15	recessed	recessed	JJ
cord-332165-31tbc31x	182	16	part	part	NN
cord-332165-31tbc31x	182	17	of	of	IN
cord-332165-31tbc31x	182	18	the	the	DT
cord-332165-31tbc31x	182	19	target	target	NN
cord-332165-31tbc31x	182	20	protein	protein	NN
cord-332165-31tbc31x	182	21	,	,	,
cord-332165-31tbc31x	182	22	it	-PRON-	PRP
cord-332165-31tbc31x	182	23	may	may	MD
cord-332165-31tbc31x	182	24	be	be	VB
cord-332165-31tbc31x	182	25	viable	viable	JJ
cord-332165-31tbc31x	182	26	to	to	TO
cord-332165-31tbc31x	182	27	directly	directly	RB
cord-332165-31tbc31x	182	28	link	link	VB
cord-332165-31tbc31x	182	29	ligand	ligand	NN
cord-332165-31tbc31x	182	30	molecules	molecule	NNS
cord-332165-31tbc31x	182	31	to	to	IN
cord-332165-31tbc31x	182	32	each	each	DT
cord-332165-31tbc31x	182	33	other	other	JJ
cord-332165-31tbc31x	182	34	instead	instead	RB
cord-332165-31tbc31x	182	35	of	of	IN
cord-332165-31tbc31x	182	36	using	use	VBG
cord-332165-31tbc31x	182	37	a	a	DT
cord-332165-31tbc31x	182	38	central	central	JJ
cord-332165-31tbc31x	182	39	scaffold	scaffold	NN
cord-332165-31tbc31x	182	40	.	.	.
cord-332165-31tbc31x	183	1	Direct	direct	JJ
cord-332165-31tbc31x	183	2	linking	linking	NN
cord-332165-31tbc31x	183	3	of	of	IN
cord-332165-31tbc31x	183	4	ligand	ligand	NN
cord-332165-31tbc31x	183	5	molecules	molecule	NNS
cord-332165-31tbc31x	183	6	may	may	MD
cord-332165-31tbc31x	183	7	eventually	eventually	RB
cord-332165-31tbc31x	183	8	result	result	VB
cord-332165-31tbc31x	183	9	in	in	IN
cord-332165-31tbc31x	183	10	the	the	DT
cord-332165-31tbc31x	183	11	design	design	NN
cord-332165-31tbc31x	183	12	of	of	IN
cord-332165-31tbc31x	183	13	a	a	DT
cord-332165-31tbc31x	183	14	circular	circular	JJ
cord-332165-31tbc31x	183	15	oligovalent	oligovalent	JJ
cord-332165-31tbc31x	183	16	inhibitor	inhibitor	NN
cord-332165-31tbc31x	183	17	.	.	.
cord-332165-31tbc31x	184	1	So	so	RB
cord-332165-31tbc31x	184	2	far	far	RB
cord-332165-31tbc31x	184	3	,	,	,
cord-332165-31tbc31x	184	4	structural	structural	JJ
cord-332165-31tbc31x	184	5	information	information	NN
cord-332165-31tbc31x	184	6	on	on	IN
cord-332165-31tbc31x	184	7	attachment	attachment	NN
cord-332165-31tbc31x	184	8	proteins	protein	NNS
cord-332165-31tbc31x	184	9	bound	bind	VBN
cord-332165-31tbc31x	184	10	by	by	IN
cord-332165-31tbc31x	184	11	oligovalent	oligovalent	NNP
cord-332165-31tbc31x	184	12	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	184	13	is	be	VBZ
cord-332165-31tbc31x	184	14	scarce	scarce	JJ
cord-332165-31tbc31x	184	15	.	.	.
cord-332165-31tbc31x	185	1	X	x	NN
cord-332165-31tbc31x	185	2	-	-	NN
cord-332165-31tbc31x	185	3	ray	ray	NN
cord-332165-31tbc31x	185	4	crystallography	crystallography	NN
cord-332165-31tbc31x	185	5	analysis	analysis	NN
cord-332165-31tbc31x	185	6	is	be	VBZ
cord-332165-31tbc31x	185	7	usually	usually	RB
cord-332165-31tbc31x	185	8	hampered	hamper	VBN
cord-332165-31tbc31x	185	9	by	by	IN
cord-332165-31tbc31x	185	10	the	the	DT
cord-332165-31tbc31x	185	11	high	high	JJ
cord-332165-31tbc31x	185	12	flexibility	flexibility	NN
cord-332165-31tbc31x	185	13	of	of	IN
cord-332165-31tbc31x	185	14	spacer	spacer	NN
cord-332165-31tbc31x	185	15	groups	group	NNS
cord-332165-31tbc31x	185	16	and	and	CC
cord-332165-31tbc31x	185	17	scaffolds	scaffold	NNS
cord-332165-31tbc31x	185	18	.	.	.
cord-332165-31tbc31x	186	1	These	these	DT
cord-332165-31tbc31x	186	2	non	non	JJ
cord-332165-31tbc31x	186	3	-	-	JJ
cord-332165-31tbc31x	186	4	binding	binding	JJ
cord-332165-31tbc31x	186	5	parts	part	NNS
cord-332165-31tbc31x	186	6	of	of	IN
cord-332165-31tbc31x	186	7	the	the	DT
cord-332165-31tbc31x	186	8	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	186	9	typically	typically	RB
cord-332165-31tbc31x	186	10	do	do	VBP
cord-332165-31tbc31x	186	11	not	not	RB
cord-332165-31tbc31x	186	12	assume	assume	VB
cord-332165-31tbc31x	186	13	defined	define	VBN
cord-332165-31tbc31x	186	14	conformations	conformation	NNS
cord-332165-31tbc31x	186	15	,	,	,
cord-332165-31tbc31x	186	16	resulting	result	VBG
cord-332165-31tbc31x	186	17	in	in	IN
cord-332165-31tbc31x	186	18	weak	weak	JJ
cord-332165-31tbc31x	186	19	and	and	CC
cord-332165-31tbc31x	186	20	uninterpretable	uninterpretable	JJ
cord-332165-31tbc31x	186	21	electron	electron	NN
cord-332165-31tbc31x	186	22	density	density	NN
cord-332165-31tbc31x	186	23	.	.	.
cord-332165-31tbc31x	187	1	This	this	DT
cord-332165-31tbc31x	187	2	was	be	VBD
cord-332165-31tbc31x	187	3	the	the	DT
cord-332165-31tbc31x	187	4	case	case	NN
cord-332165-31tbc31x	187	5	in	in	IN
cord-332165-31tbc31x	187	6	the	the	DT
cord-332165-31tbc31x	187	7	study	study	NN
cord-332165-31tbc31x	187	8	of	of	IN
cord-332165-31tbc31x	187	9	the	the	DT
cord-332165-31tbc31x	187	10	Shiga	Shiga	NNP
cord-332165-31tbc31x	187	11	-	-	HYPH
cord-332165-31tbc31x	187	12	like	like	JJ
cord-332165-31tbc31x	187	13	toxin	toxin	NN
cord-332165-31tbc31x	187	14	inhibitor	inhibitor	NN
cord-332165-31tbc31x	187	15	STARFISH	STARFISH	NNP
cord-332165-31tbc31x	187	16	,	,	,
cord-332165-31tbc31x	187	17	described	describe	VBN
cord-332165-31tbc31x	187	18	in	in	IN
cord-332165-31tbc31x	187	19	the	the	DT
cord-332165-31tbc31x	187	20	introduction	introduction	NN
cord-332165-31tbc31x	187	21	of	of	IN
cord-332165-31tbc31x	187	22	this	this	DT
cord-332165-31tbc31x	187	23	review	review	NN
cord-332165-31tbc31x	187	24	,	,	,
cord-332165-31tbc31x	187	25	where	where	WRB
cord-332165-31tbc31x	187	26	interpretable	interpretable	JJ
cord-332165-31tbc31x	187	27	electron	electron	NN
cord-332165-31tbc31x	187	28	density	density	NN
cord-332165-31tbc31x	187	29	was	be	VBD
cord-332165-31tbc31x	187	30	only	only	RB
cord-332165-31tbc31x	187	31	present	present	JJ
cord-332165-31tbc31x	187	32	for	for	IN
cord-332165-31tbc31x	187	33	the	the	DT
cord-332165-31tbc31x	187	34	bound	bind	VBN
cord-332165-31tbc31x	187	35	ligand	ligand	NN
cord-332165-31tbc31x	187	36	moieties	moiety	NNS
cord-332165-31tbc31x	187	37	of	of	IN
cord-332165-31tbc31x	187	38	the	the	DT
cord-332165-31tbc31x	187	39	compound	compound	NN
cord-332165-31tbc31x	187	40	.	.	.
cord-332165-31tbc31x	188	1	Still	still	RB
cord-332165-31tbc31x	188	2	,	,	,
cord-332165-31tbc31x	188	3	the	the	DT
cord-332165-31tbc31x	188	4	structural	structural	JJ
cord-332165-31tbc31x	188	5	characterization	characterization	NN
cord-332165-31tbc31x	188	6	of	of	IN
cord-332165-31tbc31x	188	7	virus	virus	NN
cord-332165-31tbc31x	188	8	-	-	HYPH
cord-332165-31tbc31x	188	9	inhibitor	inhibitor	NN
cord-332165-31tbc31x	188	10	interactions	interaction	NNS
cord-332165-31tbc31x	188	11	in	in	IN
cord-332165-31tbc31x	188	12	order	order	NN
cord-332165-31tbc31x	188	13	to	to	TO
cord-332165-31tbc31x	188	14	design	design	VB
cord-332165-31tbc31x	188	15	or	or	CC
cord-332165-31tbc31x	188	16	optimize	optimize	VB
cord-332165-31tbc31x	188	17	anti	anti	JJ
cord-332165-31tbc31x	188	18	-	-	JJ
cord-332165-31tbc31x	188	19	viral	viral	JJ
cord-332165-31tbc31x	188	20	compounds	compound	NNS
cord-332165-31tbc31x	188	21	has	have	VBZ
cord-332165-31tbc31x	188	22	been	be	VBN
cord-332165-31tbc31x	188	23	the	the	DT
cord-332165-31tbc31x	188	24	subject	subject	NN
cord-332165-31tbc31x	188	25	of	of	IN
cord-332165-31tbc31x	188	26	extensive	extensive	JJ
cord-332165-31tbc31x	188	27	research	research	NN
cord-332165-31tbc31x	188	28	.	.	.
cord-332165-31tbc31x	189	1	Recently	recently	RB
cord-332165-31tbc31x	189	2	,	,	,
cord-332165-31tbc31x	189	3	a	a	DT
cord-332165-31tbc31x	189	4	research	research	NN
cord-332165-31tbc31x	189	5	paper	paper	NN
cord-332165-31tbc31x	189	6	by	by	IN
cord-332165-31tbc31x	189	7	Lu	Lu	NNP
cord-332165-31tbc31x	189	8	et	et	FW
cord-332165-31tbc31x	189	9	al	al	NNP
cord-332165-31tbc31x	189	10	.	.	.
cord-332165-31tbc31x	190	1	[	[	-LRB-
cord-332165-31tbc31x	190	2	91	91	CD
cord-332165-31tbc31x	190	3	]	]	-RRB-
cord-332165-31tbc31x	190	4	reported	report	VBN
cord-332165-31tbc31x	190	5	on	on	IN
cord-332165-31tbc31x	190	6	the	the	DT
cord-332165-31tbc31x	190	7	trivalent	trivalent	JJ
cord-332165-31tbc31x	190	8	design	design	NN
cord-332165-31tbc31x	190	9	of	of	IN
cord-332165-31tbc31x	190	10	sialic	sialic	JJ
cord-332165-31tbc31x	190	11	acid	acid	NN
cord-332165-31tbc31x	190	12	bearing	bear	VBG
cord-332165-31tbc31x	190	13	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	190	14	against	against	IN
cord-332165-31tbc31x	190	15	influenza	influenza	NN
cord-332165-31tbc31x	190	16	A	a	DT
cord-332165-31tbc31x	190	17	virus	virus	NN
cord-332165-31tbc31x	190	18	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	190	19	,	,	,
cord-332165-31tbc31x	190	20	showing	show	VBG
cord-332165-31tbc31x	190	21	a	a	DT
cord-332165-31tbc31x	190	22	greater	great	JJR
cord-332165-31tbc31x	190	23	than	than	IN
cord-332165-31tbc31x	190	24	400-fold	400-fold	CD
cord-332165-31tbc31x	190	25	increase	increase	NN
cord-332165-31tbc31x	190	26	in	in	IN
cord-332165-31tbc31x	190	27	affinity	affinity	NN
cord-332165-31tbc31x	190	28	compared	compare	VBN
cord-332165-31tbc31x	190	29	to	to	IN
cord-332165-31tbc31x	190	30	the	the	DT
cord-332165-31tbc31x	190	31	monovalent	monovalent	JJ
cord-332165-31tbc31x	190	32	ligand	ligand	NN
cord-332165-31tbc31x	190	33	.	.	.
cord-332165-31tbc31x	191	1	However	however	RB
cord-332165-31tbc31x	191	2	,	,	,
cord-332165-31tbc31x	191	3	structural	structural	JJ
cord-332165-31tbc31x	191	4	data	datum	NNS
cord-332165-31tbc31x	191	5	of	of	IN
cord-332165-31tbc31x	191	6	the	the	DT
cord-332165-31tbc31x	191	7	interactions	interaction	NNS
cord-332165-31tbc31x	191	8	between	between	IN
cord-332165-31tbc31x	191	9	the	the	DT
cord-332165-31tbc31x	191	10	inhibitor	inhibitor	NN
cord-332165-31tbc31x	191	11	and	and	CC
cord-332165-31tbc31x	191	12	hemagglutinin	hemagglutinin	NNS
cord-332165-31tbc31x	191	13	were	be	VBD
cord-332165-31tbc31x	191	14	not	not	RB
cord-332165-31tbc31x	191	15	reported	report	VBN
cord-332165-31tbc31x	191	16	in	in	IN
cord-332165-31tbc31x	191	17	that	that	DT
cord-332165-31tbc31x	191	18	study	study	NN
cord-332165-31tbc31x	191	19	.	.	.
cord-332165-31tbc31x	192	1	One	one	CD
cord-332165-31tbc31x	192	2	study	study	NN
cord-332165-31tbc31x	192	3	of	of	IN
cord-332165-31tbc31x	192	4	a	a	DT
cord-332165-31tbc31x	192	5	central	central	JJ
cord-332165-31tbc31x	192	6	group	group	NN
cord-332165-31tbc31x	192	7	-	-	HYPH
cord-332165-31tbc31x	192	8	based	base	VBN
cord-332165-31tbc31x	192	9	anti	anti	JJ
cord-332165-31tbc31x	192	10	-	-	JJ
cord-332165-31tbc31x	192	11	viral	viral	JJ
cord-332165-31tbc31x	192	12	inhibitor	inhibitor	NN
cord-332165-31tbc31x	192	13	,	,	,
cord-332165-31tbc31x	192	14	which	which	WDT
cord-332165-31tbc31x	192	15	contains	contain	VBZ
cord-332165-31tbc31x	192	16	structural	structural	JJ
cord-332165-31tbc31x	192	17	data	datum	NNS
cord-332165-31tbc31x	192	18	,	,	,
cord-332165-31tbc31x	192	19	can	can	MD
cord-332165-31tbc31x	192	20	be	be	VB
cord-332165-31tbc31x	192	21	found	find	VBN
cord-332165-31tbc31x	192	22	for	for	IN
cord-332165-31tbc31x	192	23	adenoviruses	adenovirus	NNS
cord-332165-31tbc31x	192	24	.	.	.
cord-332165-31tbc31x	193	1	Adenoviridae	Adenoviridae	NNP
cord-332165-31tbc31x	193	2	members	member	NNS
cord-332165-31tbc31x	193	3	carry	carry	VBP
cord-332165-31tbc31x	193	4	trimeric	trimeric	JJ
cord-332165-31tbc31x	193	5	fibers	fiber	NNS
cord-332165-31tbc31x	193	6	terminating	terminate	VBG
cord-332165-31tbc31x	193	7	in	in	IN
cord-332165-31tbc31x	193	8	the	the	DT
cord-332165-31tbc31x	193	9	knob	knob	NN
cord-332165-31tbc31x	193	10	domain	domain	NN
cord-332165-31tbc31x	193	11	,	,	,
cord-332165-31tbc31x	193	12	which	which	WDT
cord-332165-31tbc31x	193	13	engages	engage	VBZ
cord-332165-31tbc31x	193	14	sialic	sialic	JJ
cord-332165-31tbc31x	193	15	acid	acid	NN
cord-332165-31tbc31x	193	16	-	-	HYPH
cord-332165-31tbc31x	193	17	based	base	VBN
cord-332165-31tbc31x	193	18	receptors	receptor	NNS
cord-332165-31tbc31x	193	19	in	in	IN
cord-332165-31tbc31x	193	20	some	some	DT
cord-332165-31tbc31x	193	21	adenoviruses	adenovirus	NNS
cord-332165-31tbc31x	193	22	.	.	.
cord-332165-31tbc31x	194	1	Human	Human	NNP
cord-332165-31tbc31x	194	2	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	194	3	37	37	CD
cord-332165-31tbc31x	194	4	(	(	-LRB-
cord-332165-31tbc31x	194	5	HAdV37	HAdV37	NNP
cord-332165-31tbc31x	194	6	)	)	-RRB-
cord-332165-31tbc31x	194	7	,	,	,
cord-332165-31tbc31x	194	8	which	which	WDT
cord-332165-31tbc31x	194	9	causes	cause	VBZ
cord-332165-31tbc31x	194	10	Epidemic	Epidemic	NNP
cord-332165-31tbc31x	194	11	Keratoconjunctivitis	Keratoconjunctivitis	NNP
cord-332165-31tbc31x	194	12	(	(	-LRB-
cord-332165-31tbc31x	194	13	EKC	EKC	NNP
cord-332165-31tbc31x	194	14	)	)	-RRB-
cord-332165-31tbc31x	194	15	,	,	,
cord-332165-31tbc31x	194	16	carries	carry	VBZ
cord-332165-31tbc31x	194	17	three	three	CD
cord-332165-31tbc31x	194	18	individual	individual	JJ
cord-332165-31tbc31x	194	19	binding	bind	VBG
cord-332165-31tbc31x	194	20	sites	site	NNS
cord-332165-31tbc31x	194	21	for	for	IN
cord-332165-31tbc31x	194	22	sialic	sialic	JJ
cord-332165-31tbc31x	194	23	acids	acid	NNS
cord-332165-31tbc31x	194	24	in	in	IN
cord-332165-31tbc31x	194	25	its	-PRON-	PRP$
cord-332165-31tbc31x	194	26	fiber	fiber	NN
cord-332165-31tbc31x	194	27	knob	knob	NN
cord-332165-31tbc31x	194	28	,	,	,
cord-332165-31tbc31x	194	29	which	which	WDT
cord-332165-31tbc31x	194	30	are	be	VBP
cord-332165-31tbc31x	194	31	located	locate	VBN
cord-332165-31tbc31x	194	32	at	at	IN
cord-332165-31tbc31x	194	33	a	a	DT
cord-332165-31tbc31x	194	34	distance	distance	NN
cord-332165-31tbc31x	194	35	of	of	IN
cord-332165-31tbc31x	194	36	6	6	CD
cord-332165-31tbc31x	194	37	Å	å	NN
cord-332165-31tbc31x	194	38	from	from	IN
cord-332165-31tbc31x	194	39	the	the	DT
cord-332165-31tbc31x	194	40	local	local	JJ
cord-332165-31tbc31x	194	41	three	three	CD
cord-332165-31tbc31x	194	42	-	-	HYPH
cord-332165-31tbc31x	194	43	fold	fold	JJ
cord-332165-31tbc31x	194	44	symmetric	symmetric	JJ
cord-332165-31tbc31x	194	45	axis	axis	NN
cord-332165-31tbc31x	194	46	(	(	-LRB-
cord-332165-31tbc31x	194	47	Figure	figure	NN
cord-332165-31tbc31x	194	48	4a	4a	CD
cord-332165-31tbc31x	194	49	)	)	-RRB-
cord-332165-31tbc31x	194	50	[	[	-LRB-
cord-332165-31tbc31x	194	51	68	68	CD
cord-332165-31tbc31x	194	52	]	]	-RRB-
cord-332165-31tbc31x	194	53	.	.	.
cord-332165-31tbc31x	195	1	The	the	DT
cord-332165-31tbc31x	195	2	physiologic	physiologic	JJ
cord-332165-31tbc31x	195	3	receptor	receptor	NN
cord-332165-31tbc31x	195	4	of	of	IN
cord-332165-31tbc31x	195	5	HAdV37	HAdV37	NNP
cord-332165-31tbc31x	195	6	is	be	VBZ
cord-332165-31tbc31x	195	7	the	the	DT
cord-332165-31tbc31x	195	8	glycan	glycan	NN
cord-332165-31tbc31x	195	9	portion	portion	NN
cord-332165-31tbc31x	195	10	of	of	IN
cord-332165-31tbc31x	195	11	ganglioside	ganglioside	NN
cord-332165-31tbc31x	195	12	GD1a	GD1a	NNP
cord-332165-31tbc31x	195	13	.	.	.
cord-332165-31tbc31x	196	1	This	this	DT
cord-332165-31tbc31x	196	2	glycan	glycan	NN
cord-332165-31tbc31x	196	3	is	be	VBZ
cord-332165-31tbc31x	196	4	a	a	DT
cord-332165-31tbc31x	196	5	branched	branched	JJ
cord-332165-31tbc31x	196	6	hexasaccharide	hexasaccharide	NN
cord-332165-31tbc31x	196	7	with	with	IN
cord-332165-31tbc31x	196	8	two	two	CD
cord-332165-31tbc31x	196	9	terminal	terminal	JJ
cord-332165-31tbc31x	196	10	sialic	sialic	NN
cord-332165-31tbc31x	196	11	acid	acid	NN
cord-332165-31tbc31x	196	12	moieties	moiety	NNS
cord-332165-31tbc31x	196	13	,	,	,
cord-332165-31tbc31x	196	14	both	both	DT
cord-332165-31tbc31x	196	15	of	of	IN
cord-332165-31tbc31x	196	16	which	which	WDT
cord-332165-31tbc31x	196	17	were	be	VBD
cord-332165-31tbc31x	196	18	shown	show	VBN
cord-332165-31tbc31x	196	19	to	to	TO
cord-332165-31tbc31x	196	20	simultaneously	simultaneously	RB
cord-332165-31tbc31x	196	21	occupy	occupy	VB
cord-332165-31tbc31x	196	22	two	two	CD
cord-332165-31tbc31x	196	23	of	of	IN
cord-332165-31tbc31x	196	24	the	the	DT
cord-332165-31tbc31x	196	25	three	three	CD
cord-332165-31tbc31x	196	26	available	available	JJ
cord-332165-31tbc31x	196	27	sialic	sialic	NN
cord-332165-31tbc31x	196	28	acid	acid	NN
cord-332165-31tbc31x	196	29	binding	bind	VBG
cord-332165-31tbc31x	196	30	sites	site	NNS
cord-332165-31tbc31x	196	31	in	in	IN
cord-332165-31tbc31x	196	32	the	the	DT
cord-332165-31tbc31x	196	33	same	same	JJ
cord-332165-31tbc31x	196	34	fiber	fiber	NN
cord-332165-31tbc31x	196	35	knob	knob	NN
cord-332165-31tbc31x	196	36	[	[	-LRB-
cord-332165-31tbc31x	196	37	92	92	CD
cord-332165-31tbc31x	196	38	]	]	-RRB-
cord-332165-31tbc31x	196	39	.	.	.
cord-332165-31tbc31x	197	1	Based	base	VBN
cord-332165-31tbc31x	197	2	on	on	IN
cord-332165-31tbc31x	197	3	this	this	DT
cord-332165-31tbc31x	197	4	observation	observation	NN
cord-332165-31tbc31x	197	5	,	,	,
cord-332165-31tbc31x	197	6	Spjut	Spjut	NNP
cord-332165-31tbc31x	197	7	et	et	FW
cord-332165-31tbc31x	197	8	al	al	NNP
cord-332165-31tbc31x	197	9	.	.	.
cord-332165-31tbc31x	198	1	(	(	-LRB-
cord-332165-31tbc31x	198	2	2011	2011	CD
cord-332165-31tbc31x	198	3	)	)	-RRB-
cord-332165-31tbc31x	199	1	[	[	-LRB-
cord-332165-31tbc31x	199	2	93	93	CD
cord-332165-31tbc31x	199	3	]	]	-RRB-
cord-332165-31tbc31x	199	4	designed	design	VBN
cord-332165-31tbc31x	199	5	and	and	CC
cord-332165-31tbc31x	199	6	synthesized	synthesize	VBD
cord-332165-31tbc31x	199	7	a	a	DT
cord-332165-31tbc31x	199	8	symmetric	symmetric	JJ
cord-332165-31tbc31x	199	9	,	,	,
cord-332165-31tbc31x	199	10	tridentate	tridentate	JJ
cord-332165-31tbc31x	199	11	sialylated	sialylated	JJ
cord-332165-31tbc31x	199	12	inhibitor	inhibitor	NN
cord-332165-31tbc31x	199	13	,	,	,
cord-332165-31tbc31x	199	14	which	which	WDT
cord-332165-31tbc31x	199	15	is	be	VBZ
cord-332165-31tbc31x	199	16	capable	capable	JJ
cord-332165-31tbc31x	199	17	of	of	IN
cord-332165-31tbc31x	199	18	occupying	occupy	VBG
cord-332165-31tbc31x	199	19	all	all	DT
cord-332165-31tbc31x	199	20	three	three	CD
cord-332165-31tbc31x	199	21	binding	bind	VBG
cord-332165-31tbc31x	199	22	sites	site	NNS
cord-332165-31tbc31x	199	23	of	of	IN
cord-332165-31tbc31x	199	24	the	the	DT
cord-332165-31tbc31x	199	25	fiber	fiber	NN
cord-332165-31tbc31x	199	26	knob	knob	NN
cord-332165-31tbc31x	199	27	at	at	IN
cord-332165-31tbc31x	199	28	once	once	RB
cord-332165-31tbc31x	199	29	.	.	.
cord-332165-31tbc31x	200	1	The	the	DT
cord-332165-31tbc31x	200	2	first	first	JJ
cord-332165-31tbc31x	200	3	generation	generation	NN
cord-332165-31tbc31x	200	4	of	of	IN
cord-332165-31tbc31x	200	5	these	these	DT
cord-332165-31tbc31x	200	6	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	200	7	was	be	VBD
cord-332165-31tbc31x	200	8	designed	design	VBN
cord-332165-31tbc31x	200	9	around	around	IN
cord-332165-31tbc31x	200	10	a	a	DT
cord-332165-31tbc31x	200	11	central	central	JJ
cord-332165-31tbc31x	200	12	tris(2-aminoethyl	tris(2-aminoethyl	NNP
cord-332165-31tbc31x	200	13	)	)	-RRB-
cord-332165-31tbc31x	200	14	amine	amine	NN
cord-332165-31tbc31x	200	15	group	group	NN
cord-332165-31tbc31x	200	16	.	.	.
cord-332165-31tbc31x	201	1	It	-PRON-	PRP
cord-332165-31tbc31x	201	2	utilized	utilize	VBD
cord-332165-31tbc31x	201	3	flexible	flexible	JJ
cord-332165-31tbc31x	201	4	spacers	spacer	NNS
cord-332165-31tbc31x	201	5	between	between	IN
cord-332165-31tbc31x	201	6	the	the	DT
cord-332165-31tbc31x	201	7	central	central	JJ
cord-332165-31tbc31x	201	8	group	group	NN
cord-332165-31tbc31x	201	9	and	and	CC
cord-332165-31tbc31x	201	10	the	the	DT
cord-332165-31tbc31x	201	11	sialic	sialic	JJ
cord-332165-31tbc31x	201	12	acid	acid	NN
cord-332165-31tbc31x	201	13	ligand	ligand	NN
cord-332165-31tbc31x	201	14	,	,	,
cord-332165-31tbc31x	201	15	in	in	IN
cord-332165-31tbc31x	201	16	order	order	NN
cord-332165-31tbc31x	201	17	to	to	TO
cord-332165-31tbc31x	201	18	minimize	minimize	VB
cord-332165-31tbc31x	201	19	the	the	DT
cord-332165-31tbc31x	201	20	chance	chance	NN
cord-332165-31tbc31x	201	21	of	of	IN
cord-332165-31tbc31x	201	22	steric	steric	JJ
cord-332165-31tbc31x	201	23	hindrance	hindrance	NN
cord-332165-31tbc31x	201	24	of	of	IN
cord-332165-31tbc31x	201	25	the	the	DT
cord-332165-31tbc31x	201	26	inhibitor	inhibitor	NN
cord-332165-31tbc31x	201	27	docking	docking	NN
cord-332165-31tbc31x	201	28	.	.	.
cord-332165-31tbc31x	202	1	The	the	DT
cord-332165-31tbc31x	202	2	resulting	result	VBG
cord-332165-31tbc31x	202	3	compounds	compound	NNS
cord-332165-31tbc31x	202	4	demonstrated	demonstrate	VBD
cord-332165-31tbc31x	202	5	a	a	DT
cord-332165-31tbc31x	202	6	potency	potency	JJ
cord-332165-31tbc31x	202	7	increase	increase	NN
cord-332165-31tbc31x	202	8	of	of	IN
cord-332165-31tbc31x	202	9	four	four	CD
cord-332165-31tbc31x	202	10	orders	order	NNS
cord-332165-31tbc31x	202	11	of	of	IN
cord-332165-31tbc31x	202	12	magnitude	magnitude	NN
cord-332165-31tbc31x	202	13	compared	compare	VBN
cord-332165-31tbc31x	202	14	to	to	IN
cord-332165-31tbc31x	202	15	monomeric	monomeric	JJ
cord-332165-31tbc31x	202	16	sialic	sialic	NN
cord-332165-31tbc31x	202	17	acid	acid	NN
cord-332165-31tbc31x	202	18	[	[	-LRB-
cord-332165-31tbc31x	202	19	93	93	CD
cord-332165-31tbc31x	202	20	]	]	-RRB-
cord-332165-31tbc31x	202	21	.	.	.
cord-332165-31tbc31x	203	1	Recently	recently	RB
cord-332165-31tbc31x	203	2	,	,	,
cord-332165-31tbc31x	203	3	in	in	IN
cord-332165-31tbc31x	203	4	the	the	DT
cord-332165-31tbc31x	203	5	second	second	JJ
cord-332165-31tbc31x	203	6	-	-	HYPH
cord-332165-31tbc31x	203	7	generation	generation	NN
cord-332165-31tbc31x	203	8	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	203	9	,	,	,
cord-332165-31tbc31x	203	10	the	the	DT
cord-332165-31tbc31x	203	11	binding	bind	VBG
cord-332165-31tbc31x	203	12	affinity	affinity	NN
cord-332165-31tbc31x	203	13	could	could	MD
cord-332165-31tbc31x	203	14	be	be	VB
cord-332165-31tbc31x	203	15	improved	improve	VBN
cord-332165-31tbc31x	203	16	even	even	RB
cord-332165-31tbc31x	203	17	further	further	RB
cord-332165-31tbc31x	203	18	by	by	IN
cord-332165-31tbc31x	203	19	using	use	VBG
cord-332165-31tbc31x	203	20	a	a	DT
cord-332165-31tbc31x	203	21	shorter	short	JJR
cord-332165-31tbc31x	203	22	,	,	,
cord-332165-31tbc31x	203	23	triazole	triazole	NN
cord-332165-31tbc31x	203	24	-	-	HYPH
cord-332165-31tbc31x	203	25	based	base	VBN
cord-332165-31tbc31x	203	26	linker	linker	NN
cord-332165-31tbc31x	203	27	structure	structure	NN
cord-332165-31tbc31x	203	28	,	,	,
cord-332165-31tbc31x	203	29	which	which	WDT
cord-332165-31tbc31x	203	30	was	be	VBD
cord-332165-31tbc31x	203	31	based	base	VBN
cord-332165-31tbc31x	203	32	on	on	IN
cord-332165-31tbc31x	203	33	the	the	DT
cord-332165-31tbc31x	203	34	results	result	NNS
cord-332165-31tbc31x	203	35	of	of	IN
cord-332165-31tbc31x	203	36	the	the	DT
cord-332165-31tbc31x	203	37	first	first	JJ
cord-332165-31tbc31x	203	38	-	-	HYPH
cord-332165-31tbc31x	203	39	generation	generation	NN
cord-332165-31tbc31x	203	40	complex	complex	JJ
cord-332165-31tbc31x	203	41	structures	structure	NNS
cord-332165-31tbc31x	203	42	.	.	.
cord-332165-31tbc31x	204	1	The	the	DT
cord-332165-31tbc31x	204	2	more	more	RBR
cord-332165-31tbc31x	204	3	compact	compact	JJ
cord-332165-31tbc31x	204	4	and	and	CC
cord-332165-31tbc31x	204	5	rigid	rigid	JJ
cord-332165-31tbc31x	204	6	design	design	NN
cord-332165-31tbc31x	204	7	resulted	result	VBD
cord-332165-31tbc31x	204	8	in	in	IN
cord-332165-31tbc31x	204	9	an	an	DT
cord-332165-31tbc31x	204	10	additional	additional	JJ
cord-332165-31tbc31x	204	11	140-fold	140-fold	CD
cord-332165-31tbc31x	204	12	increase	increase	NN
cord-332165-31tbc31x	204	13	in	in	IN
cord-332165-31tbc31x	204	14	potency	potency	NN
cord-332165-31tbc31x	204	15	[	[	-LRB-
cord-332165-31tbc31x	204	16	29	29	CD
cord-332165-31tbc31x	204	17	]	]	-RRB-
cord-332165-31tbc31x	204	18	.	.	.
cord-332165-31tbc31x	205	1	The	the	DT
cord-332165-31tbc31x	205	2	crystal	crystal	NN
cord-332165-31tbc31x	205	3	structures	structure	NNS
cord-332165-31tbc31x	205	4	of	of	IN
cord-332165-31tbc31x	205	5	the	the	DT
cord-332165-31tbc31x	205	6	second	second	JJ
cord-332165-31tbc31x	205	7	-	-	HYPH
cord-332165-31tbc31x	205	8	generation	generation	NN
cord-332165-31tbc31x	205	9	inhibitor	inhibitor	NN
cord-332165-31tbc31x	205	10	molecules	molecule	NNS
cord-332165-31tbc31x	205	11	in	in	IN
cord-332165-31tbc31x	205	12	a	a	DT
cord-332165-31tbc31x	205	13	complex	complex	NN
cord-332165-31tbc31x	205	14	with	with	IN
cord-332165-31tbc31x	205	15	adenovirus	adenovirus	NN
cord-332165-31tbc31x	205	16	fiber	fiber	NN
cord-332165-31tbc31x	205	17	knob	knob	NN
cord-332165-31tbc31x	205	18	proteins	protein	NNS
cord-332165-31tbc31x	205	19	verify	verify	VBP
cord-332165-31tbc31x	205	20	the	the	DT
cord-332165-31tbc31x	205	21	trivalent	trivalent	JJ
cord-332165-31tbc31x	205	22	binding	binding	NN
cord-332165-31tbc31x	205	23	mode	mode	NN
cord-332165-31tbc31x	205	24	by	by	IN
cord-332165-31tbc31x	205	25	also	also	RB
cord-332165-31tbc31x	205	26	displaying	display	VBG
cord-332165-31tbc31x	205	27	the	the	DT
cord-332165-31tbc31x	205	28	electron	electron	NN
cord-332165-31tbc31x	205	29	density	density	NN
cord-332165-31tbc31x	205	30	of	of	IN
cord-332165-31tbc31x	205	31	the	the	DT
cord-332165-31tbc31x	205	32	linkers	linker	NNS
cord-332165-31tbc31x	205	33	(	(	-LRB-
cord-332165-31tbc31x	205	34	Figure	figure	NN
cord-332165-31tbc31x	205	35	5a	5a	CD
cord-332165-31tbc31x	205	36	,	,	,
cord-332165-31tbc31x	205	37	b	b	NN
cord-332165-31tbc31x	205	38	,	,	,
cord-332165-31tbc31x	205	39	left	leave	VBD
cord-332165-31tbc31x	205	40	)	)	-RRB-
cord-332165-31tbc31x	205	41	.	.	.
cord-332165-31tbc31x	206	1	An	an	DT
cord-332165-31tbc31x	206	2	example	example	NN
cord-332165-31tbc31x	206	3	of	of	IN
cord-332165-31tbc31x	206	4	directly	directly	RB
cord-332165-31tbc31x	206	5	-	-	HYPH
cord-332165-31tbc31x	206	6	linked	link	VBN
cord-332165-31tbc31x	206	7	ligand	ligand	NN
cord-332165-31tbc31x	206	8	moieties	moiety	NNS
cord-332165-31tbc31x	206	9	was	be	VBD
cord-332165-31tbc31x	206	10	shown	show	VBN
cord-332165-31tbc31x	206	11	in	in	IN
cord-332165-31tbc31x	206	12	a	a	DT
cord-332165-31tbc31x	206	13	study	study	NN
cord-332165-31tbc31x	206	14	of	of	IN
cord-332165-31tbc31x	206	15	potential	potential	JJ
cord-332165-31tbc31x	206	16	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	206	17	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	206	18	,	,	,
cord-332165-31tbc31x	206	19	in	in	IN
cord-332165-31tbc31x	206	20	which	which	WDT
cord-332165-31tbc31x	206	21	Baier	Baier	NNP
cord-332165-31tbc31x	206	22	et	et	NNP
cord-332165-31tbc31x	206	23	al	al	NNP
cord-332165-31tbc31x	206	24	.	.	.
cord-332165-31tbc31x	207	1	[	[	-LRB-
cord-332165-31tbc31x	207	2	94	94	CD
cord-332165-31tbc31x	207	3	]	]	-RRB-
cord-332165-31tbc31x	207	4	synthesized	synthesize	VBN
cord-332165-31tbc31x	207	5	so	so	RB
cord-332165-31tbc31x	207	6	-	-	HYPH
cord-332165-31tbc31x	207	7	called	call	VBN
cord-332165-31tbc31x	207	8	divalent	divalent	JJ
cord-332165-31tbc31x	207	9	sialylated	sialylate	VBN
cord-332165-31tbc31x	207	10	glycooligopeptides	glycooligopeptide	NNS
cord-332165-31tbc31x	207	11	.	.	.
cord-332165-31tbc31x	208	1	They	-PRON-	PRP
cord-332165-31tbc31x	208	2	solved	solve	VBD
cord-332165-31tbc31x	208	3	the	the	DT
cord-332165-31tbc31x	208	4	structures	structure	NNS
cord-332165-31tbc31x	208	5	of	of	IN
cord-332165-31tbc31x	208	6	two	two	CD
cord-332165-31tbc31x	208	7	glycooligopeptide	glycooligopeptide	NN
cord-332165-31tbc31x	208	8	compounds	compound	NNS
cord-332165-31tbc31x	208	9	in	in	IN
cord-332165-31tbc31x	208	10	a	a	DT
cord-332165-31tbc31x	208	11	complex	complex	NN
cord-332165-31tbc31x	208	12	with	with	IN
cord-332165-31tbc31x	208	13	the	the	DT
cord-332165-31tbc31x	208	14	major	major	JJ
cord-332165-31tbc31x	208	15	capsid	capsid	NN
cord-332165-31tbc31x	208	16	protein	protein	NN
cord-332165-31tbc31x	208	17	(	(	-LRB-
cord-332165-31tbc31x	208	18	VP1	VP1	NNP
cord-332165-31tbc31x	208	19	)	)	-RRB-
cord-332165-31tbc31x	208	20	pentamer	pentamer	NNP
cord-332165-31tbc31x	208	21	of	of	IN
cord-332165-31tbc31x	208	22	the	the	DT
cord-332165-31tbc31x	208	23	Trichodysplasia	Trichodysplasia	NNP
cord-332165-31tbc31x	208	24	spinulosa	spinulosa	NNP
cord-332165-31tbc31x	208	25	-	-	HYPH
cord-332165-31tbc31x	208	26	associated	associate	VBN
cord-332165-31tbc31x	208	27	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	208	28	(	(	-LRB-
cord-332165-31tbc31x	208	29	TSPyV	tspyv	NN
cord-332165-31tbc31x	208	30	)	)	-RRB-
cord-332165-31tbc31x	208	31	,	,	,
cord-332165-31tbc31x	208	32	which	which	WDT
cord-332165-31tbc31x	208	33	is	be	VBZ
cord-332165-31tbc31x	208	34	associated	associate	VBN
cord-332165-31tbc31x	208	35	with	with	IN
cord-332165-31tbc31x	208	36	abnormal	abnormal	JJ
cord-332165-31tbc31x	208	37	skin	skin	NN
cord-332165-31tbc31x	208	38	growth	growth	NN
cord-332165-31tbc31x	208	39	in	in	IN
cord-332165-31tbc31x	208	40	immunocompromised	immunocompromised	JJ
cord-332165-31tbc31x	208	41	patients	patient	NNS
cord-332165-31tbc31x	208	42	.	.	.
cord-332165-31tbc31x	209	1	The	the	DT
cord-332165-31tbc31x	209	2	VP1	VP1	NNP
cord-332165-31tbc31x	209	3	pentamer	pentamer	NNP
cord-332165-31tbc31x	209	4	carries	carry	VBZ
cord-332165-31tbc31x	209	5	five	five	CD
cord-332165-31tbc31x	209	6	individual	individual	JJ
cord-332165-31tbc31x	209	7	sialic	sialic	NN
cord-332165-31tbc31x	209	8	acid	acid	NN
cord-332165-31tbc31x	209	9	binding	bind	VBG
cord-332165-31tbc31x	209	10	sites	site	NNS
cord-332165-31tbc31x	209	11	at	at	IN
cord-332165-31tbc31x	209	12	a	a	DT
cord-332165-31tbc31x	209	13	distance	distance	NN
cord-332165-31tbc31x	209	14	of	of	IN
cord-332165-31tbc31x	209	15	35	35	CD
cord-332165-31tbc31x	209	16	Å	å	NN
cord-332165-31tbc31x	209	17	between	between	IN
cord-332165-31tbc31x	209	18	neighboring	neighboring	NN
cord-332165-31tbc31x	209	19	sites	site	NNS
cord-332165-31tbc31x	209	20	[	[	-LRB-
cord-332165-31tbc31x	209	21	50	50	CD
cord-332165-31tbc31x	209	22	,	,	,
cord-332165-31tbc31x	209	23	94	94	CD
cord-332165-31tbc31x	209	24	]	]	-RRB-
cord-332165-31tbc31x	209	25	.	.	.
cord-332165-31tbc31x	210	1	The	the	DT
cord-332165-31tbc31x	210	2	glycooligopeptide	glycooligopeptide	JJ
cord-332165-31tbc31x	210	3	-	-	HYPH
cord-332165-31tbc31x	210	4	VP1	vp1	NN
cord-332165-31tbc31x	210	5	complex	complex	JJ
cord-332165-31tbc31x	210	6	structures	structure	NNS
cord-332165-31tbc31x	210	7	displayed	display	VBD
cord-332165-31tbc31x	210	8	a	a	DT
cord-332165-31tbc31x	210	9	similar	similar	JJ
cord-332165-31tbc31x	210	10	ligand	ligand	NN
cord-332165-31tbc31x	210	11	binding	binding	NN
cord-332165-31tbc31x	210	12	mode	mode	NN
cord-332165-31tbc31x	210	13	that	that	WDT
cord-332165-31tbc31x	210	14	was	be	VBD
cord-332165-31tbc31x	210	15	reported	report	VBN
cord-332165-31tbc31x	210	16	for	for	IN
cord-332165-31tbc31x	210	17	sialic	sialic	JJ
cord-332165-31tbc31x	210	18	acid	acid	NN
cord-332165-31tbc31x	210	19	in	in	IN
cord-332165-31tbc31x	210	20	an	an	DT
cord-332165-31tbc31x	210	21	earlier	early	JJR
cord-332165-31tbc31x	210	22	study	study	NN
cord-332165-31tbc31x	210	23	[	[	-LRB-
cord-332165-31tbc31x	210	24	50	50	CD
cord-332165-31tbc31x	210	25	]	]	-RRB-
cord-332165-31tbc31x	210	26	and	and	CC
cord-332165-31tbc31x	210	27	showed	show	VBD
cord-332165-31tbc31x	210	28	,	,	,
cord-332165-31tbc31x	210	29	for	for	IN
cord-332165-31tbc31x	210	30	the	the	DT
cord-332165-31tbc31x	210	31	compounds	compound	NNS
cord-332165-31tbc31x	210	32	,	,	,
cord-332165-31tbc31x	210	33	that	that	IN
cord-332165-31tbc31x	210	34	the	the	DT
cord-332165-31tbc31x	210	35	linker	linker	NN
cord-332165-31tbc31x	210	36	between	between	IN
cord-332165-31tbc31x	210	37	the	the	DT
cord-332165-31tbc31x	210	38	ligand	ligand	NN
cord-332165-31tbc31x	210	39	and	and	CC
cord-332165-31tbc31x	210	40	the	the	DT
cord-332165-31tbc31x	210	41	scaffold	scaffold	NN
cord-332165-31tbc31x	210	42	occupies	occupy	VBZ
cord-332165-31tbc31x	210	43	the	the	DT
cord-332165-31tbc31x	210	44	space	space	NN
cord-332165-31tbc31x	210	45	that	that	WDT
cord-332165-31tbc31x	210	46	is	be	VBZ
cord-332165-31tbc31x	210	47	usually	usually	RB
cord-332165-31tbc31x	210	48	targeted	target	VBN
cord-332165-31tbc31x	210	49	by	by	IN
cord-332165-31tbc31x	210	50	the	the	DT
cord-332165-31tbc31x	210	51	natural	natural	JJ
cord-332165-31tbc31x	210	52	glycan	glycan	NN
cord-332165-31tbc31x	210	53	receptor	receptor	NN
cord-332165-31tbc31x	210	54	moieties	moiety	NNS
cord-332165-31tbc31x	210	55	(	(	-LRB-
cord-332165-31tbc31x	210	56	Figure	figure	NN
cord-332165-31tbc31x	210	57	5a	5a	CD
cord-332165-31tbc31x	210	58	,	,	,
cord-332165-31tbc31x	210	59	b	b	NN
cord-332165-31tbc31x	210	60	,	,	,
cord-332165-31tbc31x	210	61	right	right	JJ
cord-332165-31tbc31x	210	62	)	)	-RRB-
cord-332165-31tbc31x	210	63	.	.	.
cord-332165-31tbc31x	211	1	However	however	RB
cord-332165-31tbc31x	211	2	,	,	,
cord-332165-31tbc31x	211	3	the	the	DT
cord-332165-31tbc31x	211	4	interconnectivity	interconnectivity	NN
cord-332165-31tbc31x	211	5	of	of	IN
cord-332165-31tbc31x	211	6	functional	functional	JJ
cord-332165-31tbc31x	211	7	receptors	receptor	NNS
cord-332165-31tbc31x	211	8	by	by	IN
cord-332165-31tbc31x	211	9	the	the	DT
cord-332165-31tbc31x	211	10	scaffold	scaffold	NN
cord-332165-31tbc31x	211	11	remained	remain	VBD
cord-332165-31tbc31x	211	12	undetermined	undetermined	JJ
cord-332165-31tbc31x	211	13	(	(	-LRB-
cord-332165-31tbc31x	211	14	probably	probably	RB
cord-332165-31tbc31x	211	15	due	due	IN
cord-332165-31tbc31x	211	16	to	to	IN
cord-332165-31tbc31x	211	17	their	-PRON-	PRP$
cord-332165-31tbc31x	211	18	flexibility	flexibility	NN
cord-332165-31tbc31x	211	19	)	)	-RRB-
cord-332165-31tbc31x	211	20	and	and	CC
cord-332165-31tbc31x	211	21	are	be	VBP
cord-332165-31tbc31x	211	22	,	,	,
cord-332165-31tbc31x	211	23	therefore	therefore	RB
cord-332165-31tbc31x	211	24	,	,	,
cord-332165-31tbc31x	211	25	the	the	DT
cord-332165-31tbc31x	211	26	average	average	NN
cord-332165-31tbc31x	211	27	of	of	IN
cord-332165-31tbc31x	211	28	several	several	JJ
cord-332165-31tbc31x	211	29	potential	potential	JJ
cord-332165-31tbc31x	211	30	bridging	bridge	VBG
cord-332165-31tbc31x	211	31	modes	mode	NNS
cord-332165-31tbc31x	211	32	on	on	IN
cord-332165-31tbc31x	211	33	top	top	NN
cord-332165-31tbc31x	211	34	of	of	IN
cord-332165-31tbc31x	211	35	the	the	DT
cord-332165-31tbc31x	211	36	pentamers	pentamer	NNS
cord-332165-31tbc31x	211	37	[	[	-LRB-
cord-332165-31tbc31x	211	38	94	94	CD
cord-332165-31tbc31x	211	39	]	]	-RRB-
cord-332165-31tbc31x	211	40	.	.	.
cord-332165-31tbc31x	212	1	Many	many	JJ
cord-332165-31tbc31x	212	2	viral	viral	JJ
cord-332165-31tbc31x	212	3	lectins	lectin	NNS
cord-332165-31tbc31x	212	4	or	or	CC
cord-332165-31tbc31x	212	5	attachment	attachment	NN
cord-332165-31tbc31x	212	6	proteins	protein	NNS
cord-332165-31tbc31x	212	7	rely	rely	VBP
cord-332165-31tbc31x	212	8	on	on	IN
cord-332165-31tbc31x	212	9	the	the	DT
cord-332165-31tbc31x	212	10	recognition	recognition	NN
cord-332165-31tbc31x	212	11	of	of	IN
cord-332165-31tbc31x	212	12	sialic	sialic	JJ
cord-332165-31tbc31x	212	13	acids	acid	NNS
cord-332165-31tbc31x	212	14	.	.	.
cord-332165-31tbc31x	213	1	Due	due	IN
cord-332165-31tbc31x	213	2	to	to	IN
cord-332165-31tbc31x	213	3	the	the	DT
cord-332165-31tbc31x	213	4	high	high	JJ
cord-332165-31tbc31x	213	5	symmetry	symmetry	NN
cord-332165-31tbc31x	213	6	of	of	IN
cord-332165-31tbc31x	213	7	viral	viral	JJ
cord-332165-31tbc31x	213	8	particles	particle	NNS
cord-332165-31tbc31x	213	9	and	and	CC
cord-332165-31tbc31x	213	10	the	the	DT
cord-332165-31tbc31x	213	11	occurrence	occurrence	NN
cord-332165-31tbc31x	213	12	of	of	IN
cord-332165-31tbc31x	213	13	local	local	JJ
cord-332165-31tbc31x	213	14	symmetry	symmetry	NN
cord-332165-31tbc31x	213	15	within	within	IN
cord-332165-31tbc31x	213	16	commonly	commonly	RB
cord-332165-31tbc31x	213	17	multimeric	multimeric	JJ
cord-332165-31tbc31x	213	18	viral	viral	JJ
cord-332165-31tbc31x	213	19	proteins	protein	NNS
cord-332165-31tbc31x	213	20	,	,	,
cord-332165-31tbc31x	213	21	sialic	sialic	JJ
cord-332165-31tbc31x	213	22	acid	acid	NN
cord-332165-31tbc31x	213	23	binding	binding	NN
cord-332165-31tbc31x	213	24	often	often	RB
cord-332165-31tbc31x	213	25	occurs	occur	VBZ
cord-332165-31tbc31x	213	26	in	in	IN
cord-332165-31tbc31x	213	27	a	a	DT
cord-332165-31tbc31x	213	28	symmetrical	symmetrical	JJ
cord-332165-31tbc31x	213	29	context	context	NN
cord-332165-31tbc31x	213	30	,	,	,
cord-332165-31tbc31x	213	31	too	too	RB
cord-332165-31tbc31x	213	32	.	.	.
cord-332165-31tbc31x	214	1	This	this	DT
cord-332165-31tbc31x	214	2	symmetry	symmetry	NN
cord-332165-31tbc31x	214	3	is	be	VBZ
cord-332165-31tbc31x	214	4	a	a	DT
cord-332165-31tbc31x	214	5	convenient	convenient	JJ
cord-332165-31tbc31x	214	6	framework	framework	NN
cord-332165-31tbc31x	214	7	for	for	IN
cord-332165-31tbc31x	214	8	the	the	DT
cord-332165-31tbc31x	214	9	design	design	NN
cord-332165-31tbc31x	214	10	of	of	IN
cord-332165-31tbc31x	214	11	tailor	tailor	NN
cord-332165-31tbc31x	214	12	-	-	HYPH
cord-332165-31tbc31x	214	13	made	make	VBN
cord-332165-31tbc31x	214	14	inhibitory	inhibitory	JJ
cord-332165-31tbc31x	214	15	ligands	ligand	NNS
cord-332165-31tbc31x	214	16	competing	compete	VBG
cord-332165-31tbc31x	214	17	with	with	IN
cord-332165-31tbc31x	214	18	the	the	DT
cord-332165-31tbc31x	214	19	high	high	JJ
cord-332165-31tbc31x	214	20	avidity	avidity	NN
cord-332165-31tbc31x	214	21	of	of	IN
cord-332165-31tbc31x	214	22	virus	virus	NN
cord-332165-31tbc31x	214	23	-	-	HYPH
cord-332165-31tbc31x	214	24	cell	cell	NN
cord-332165-31tbc31x	214	25	interactions	interaction	NNS
cord-332165-31tbc31x	214	26	.	.	.
cord-332165-31tbc31x	215	1	Structural	structural	JJ
cord-332165-31tbc31x	215	2	biology	biology	NN
cord-332165-31tbc31x	215	3	techniques	technique	NNS
cord-332165-31tbc31x	215	4	,	,	,
cord-332165-31tbc31x	215	5	such	such	JJ
cord-332165-31tbc31x	215	6	as	as	IN
cord-332165-31tbc31x	215	7	X	x	NN
cord-332165-31tbc31x	215	8	-	-	NN
cord-332165-31tbc31x	215	9	ray	ray	NN
cord-332165-31tbc31x	215	10	crystallography	crystallography	NN
cord-332165-31tbc31x	215	11	and	and	CC
cord-332165-31tbc31x	215	12	single	single	JJ
cord-332165-31tbc31x	215	13	-	-	HYPH
cord-332165-31tbc31x	215	14	particle	particle	NN
cord-332165-31tbc31x	215	15	electron	electron	NN
cord-332165-31tbc31x	215	16	cryo	cryo	NN
cord-332165-31tbc31x	215	17	-	-	HYPH
cord-332165-31tbc31x	215	18	microscopy	microscopy	JJ
cord-332165-31tbc31x	215	19	(	(	-LRB-
cord-332165-31tbc31x	215	20	cryo	cryo	NN
cord-332165-31tbc31x	215	21	-	-	HYPH
cord-332165-31tbc31x	215	22	EM	EM	NNP
cord-332165-31tbc31x	215	23	)	)	-RRB-
cord-332165-31tbc31x	215	24	,	,	,
cord-332165-31tbc31x	215	25	can	can	MD
cord-332165-31tbc31x	215	26	now	now	RB
cord-332165-31tbc31x	215	27	tackle	tackle	VB
cord-332165-31tbc31x	215	28	the	the	DT
cord-332165-31tbc31x	215	29	visualization	visualization	NN
cord-332165-31tbc31x	215	30	of	of	IN
cord-332165-31tbc31x	215	31	viral	viral	JJ
cord-332165-31tbc31x	215	32	attachment	attachment	NN
cord-332165-31tbc31x	215	33	and	and	CC
cord-332165-31tbc31x	215	34	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	215	35	interactions	interaction	NNS
cord-332165-31tbc31x	215	36	with	with	IN
cord-332165-31tbc31x	215	37	unprecedented	unprecedented	JJ
cord-332165-31tbc31x	215	38	scope	scope	NN
cord-332165-31tbc31x	215	39	and	and	CC
cord-332165-31tbc31x	215	40	detail	detail	NN
cord-332165-31tbc31x	215	41	.	.	.
cord-332165-31tbc31x	216	1	The	the	DT
cord-332165-31tbc31x	216	2	resulting	result	VBG
cord-332165-31tbc31x	216	3	structural	structural	JJ
cord-332165-31tbc31x	216	4	data	datum	NNS
cord-332165-31tbc31x	216	5	can	can	MD
cord-332165-31tbc31x	216	6	be	be	VB
cord-332165-31tbc31x	216	7	used	use	VBN
cord-332165-31tbc31x	216	8	for	for	IN
cord-332165-31tbc31x	216	9	the	the	DT
cord-332165-31tbc31x	216	10	optimization	optimization	NN
cord-332165-31tbc31x	216	11	of	of	IN
cord-332165-31tbc31x	216	12	anti	anti	JJ
cord-332165-31tbc31x	216	13	-	-	JJ
cord-332165-31tbc31x	216	14	viral	viral	JJ
cord-332165-31tbc31x	216	15	compounds	compound	NNS
cord-332165-31tbc31x	216	16	,	,	,
cord-332165-31tbc31x	216	17	which	which	WDT
cord-332165-31tbc31x	216	18	could	could	MD
cord-332165-31tbc31x	216	19	be	be	VB
cord-332165-31tbc31x	216	20	developed	develop	VBN
cord-332165-31tbc31x	216	21	further	further	RB
cord-332165-31tbc31x	216	22	into	into	IN
cord-332165-31tbc31x	216	23	high	high	JJ
cord-332165-31tbc31x	216	24	-	-	HYPH
cord-332165-31tbc31x	216	25	affinity	affinity	NN
cord-332165-31tbc31x	216	26	drug	drug	NN
cord-332165-31tbc31x	216	27	candidates	candidate	NNS
cord-332165-31tbc31x	216	28	.	.	.
cord-332165-31tbc31x	217	1	However	however	RB
cord-332165-31tbc31x	217	2	,	,	,
cord-332165-31tbc31x	217	3	challenges	challenge	NNS
cord-332165-31tbc31x	217	4	in	in	IN
cord-332165-31tbc31x	217	5	compound	compound	NN
cord-332165-31tbc31x	217	6	design	design	NN
cord-332165-31tbc31x	217	7	remain	remain	VBP
cord-332165-31tbc31x	217	8	.	.	.
cord-332165-31tbc31x	218	1	For	for	IN
cord-332165-31tbc31x	218	2	example	example	NN
cord-332165-31tbc31x	218	3	,	,	,
cord-332165-31tbc31x	218	4	the	the	DT
cord-332165-31tbc31x	218	5	higher	high	JJR
cord-332165-31tbc31x	218	6	rigidity	rigidity	NN
cord-332165-31tbc31x	218	7	of	of	IN
cord-332165-31tbc31x	218	8	a	a	DT
cord-332165-31tbc31x	218	9	multivalent	multivalent	JJ
cord-332165-31tbc31x	218	10	ligand	ligand	NN
cord-332165-31tbc31x	218	11	does	do	VBZ
cord-332165-31tbc31x	218	12	not	not	RB
cord-332165-31tbc31x	218	13	necessarily	necessarily	RB
cord-332165-31tbc31x	218	14	translate	translate	VB
cord-332165-31tbc31x	218	15	into	into	IN
cord-332165-31tbc31x	218	16	improved	improve	VBN
cord-332165-31tbc31x	218	17	binding	binding	NN
cord-332165-31tbc31x	218	18	.	.	.
cord-332165-31tbc31x	219	1	In	in	IN
cord-332165-31tbc31x	219	2	the	the	DT
cord-332165-31tbc31x	219	3	case	case	NN
cord-332165-31tbc31x	219	4	of	of	IN
cord-332165-31tbc31x	219	5	HAd37	HAd37	NNP
cord-332165-31tbc31x	219	6	,	,	,
cord-332165-31tbc31x	219	7	a	a	DT
cord-332165-31tbc31x	219	8	rigid	rigid	JJ
cord-332165-31tbc31x	219	9	compound	compound	NN
cord-332165-31tbc31x	219	10	bound	bind	VBN
cord-332165-31tbc31x	219	11	200-fold	200-fold	CD
cord-332165-31tbc31x	219	12	less	less	RBR
cord-332165-31tbc31x	219	13	well	well	RB
cord-332165-31tbc31x	219	14	to	to	IN
cord-332165-31tbc31x	219	15	the	the	DT
cord-332165-31tbc31x	219	16	fiber	fiber	NN
cord-332165-31tbc31x	219	17	knob	knob	NN
cord-332165-31tbc31x	219	18	than	than	IN
cord-332165-31tbc31x	219	19	a	a	DT
cord-332165-31tbc31x	219	20	related	relate	VBN
cord-332165-31tbc31x	219	21	compound	compound	NN
cord-332165-31tbc31x	219	22	that	that	WDT
cord-332165-31tbc31x	219	23	had	have	VBD
cord-332165-31tbc31x	219	24	higher	high	JJR
cord-332165-31tbc31x	219	25	flexibility	flexibility	NN
cord-332165-31tbc31x	219	26	[	[	-LRB-
cord-332165-31tbc31x	219	27	29	29	CD
cord-332165-31tbc31x	219	28	]	]	-RRB-
cord-332165-31tbc31x	219	29	.	.	.
cord-332165-31tbc31x	220	1	This	this	DT
cord-332165-31tbc31x	220	2	suggests	suggest	VBZ
cord-332165-31tbc31x	220	3	that	that	IN
cord-332165-31tbc31x	220	4	the	the	DT
cord-332165-31tbc31x	220	5	perfect	perfect	JJ
cord-332165-31tbc31x	220	6	positioning	positioning	NN
cord-332165-31tbc31x	220	7	of	of	IN
cord-332165-31tbc31x	220	8	all	all	DT
cord-332165-31tbc31x	220	9	sialic	sialic	JJ
cord-332165-31tbc31x	220	10	acids	acid	NNS
cord-332165-31tbc31x	220	11	in	in	IN
cord-332165-31tbc31x	220	12	the	the	DT
cord-332165-31tbc31x	220	13	binding	binding	NN
cord-332165-31tbc31x	220	14	site	site	NN
cord-332165-31tbc31x	220	15	,	,	,
cord-332165-31tbc31x	220	16	especially	especially	RB
cord-332165-31tbc31x	220	17	for	for	IN
cord-332165-31tbc31x	220	18	larger	large	JJR
cord-332165-31tbc31x	220	19	inhibitor	inhibitor	NN
cord-332165-31tbc31x	220	20	molecules	molecule	NNS
cord-332165-31tbc31x	220	21	,	,	,
cord-332165-31tbc31x	220	22	is	be	VBZ
cord-332165-31tbc31x	220	23	difficult	difficult	JJ
cord-332165-31tbc31x	220	24	to	to	TO
cord-332165-31tbc31x	220	25	achieve	achieve	VB
cord-332165-31tbc31x	220	26	,	,	,
cord-332165-31tbc31x	220	27	and	and	CC
cord-332165-31tbc31x	220	28	a	a	DT
cord-332165-31tbc31x	220	29	certain	certain	JJ
cord-332165-31tbc31x	220	30	degree	degree	NN
cord-332165-31tbc31x	220	31	of	of	IN
cord-332165-31tbc31x	220	32	flexibility	flexibility	NN
cord-332165-31tbc31x	220	33	might	may	MD
cord-332165-31tbc31x	220	34	help	help	VB
cord-332165-31tbc31x	220	35	with	with	IN
cord-332165-31tbc31x	220	36	the	the	DT
cord-332165-31tbc31x	220	37	high	high	JJ
cord-332165-31tbc31x	220	38	-	-	HYPH
cord-332165-31tbc31x	220	39	affinity	affinity	NN
cord-332165-31tbc31x	220	40	binding	binding	NN
cord-332165-31tbc31x	220	41	of	of	IN
cord-332165-31tbc31x	220	42	the	the	DT
cord-332165-31tbc31x	220	43	inhibitor	inhibitor	NN
cord-332165-31tbc31x	220	44	.	.	.
cord-332165-31tbc31x	221	1	Another	another	DT
cord-332165-31tbc31x	221	2	limiting	limit	VBG
cord-332165-31tbc31x	221	3	factor	factor	NN
cord-332165-31tbc31x	221	4	for	for	IN
cord-332165-31tbc31x	221	5	oligovalent	oligovalent	JJ
cord-332165-31tbc31x	221	6	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	221	7	is	be	VBZ
cord-332165-31tbc31x	221	8	the	the	DT
cord-332165-31tbc31x	221	9	positioning	positioning	NN
cord-332165-31tbc31x	221	10	of	of	IN
cord-332165-31tbc31x	221	11	the	the	DT
cord-332165-31tbc31x	221	12	binding	bind	VBG
cord-332165-31tbc31x	221	13	pockets	pocket	NNS
cord-332165-31tbc31x	221	14	.	.	.
cord-332165-31tbc31x	222	1	In	in	IN
cord-332165-31tbc31x	222	2	the	the	DT
cord-332165-31tbc31x	222	3	case	case	NN
cord-332165-31tbc31x	222	4	of	of	IN
cord-332165-31tbc31x	222	5	the	the	DT
cord-332165-31tbc31x	222	6	trivalent	trivalent	JJ
cord-332165-31tbc31x	222	7	adenovirus	adenovirus	NN
cord-332165-31tbc31x	222	8	inhibitor	inhibitor	NN
cord-332165-31tbc31x	222	9	,	,	,
cord-332165-31tbc31x	222	10	the	the	DT
cord-332165-31tbc31x	222	11	binding	bind	VBG
cord-332165-31tbc31x	222	12	sites	site	NNS
cord-332165-31tbc31x	222	13	are	be	VBP
cord-332165-31tbc31x	222	14	on	on	IN
cord-332165-31tbc31x	222	15	the	the	DT
cord-332165-31tbc31x	222	16	very	very	JJ
cord-332165-31tbc31x	222	17	top	top	NN
cord-332165-31tbc31x	222	18	of	of	IN
cord-332165-31tbc31x	222	19	the	the	DT
cord-332165-31tbc31x	222	20	knob	knob	NN
cord-332165-31tbc31x	222	21	domain	domain	NN
cord-332165-31tbc31x	222	22	,	,	,
cord-332165-31tbc31x	222	23	so	so	CC
cord-332165-31tbc31x	222	24	there	there	EX
cord-332165-31tbc31x	222	25	is	be	VBZ
cord-332165-31tbc31x	222	26	enough	enough	JJ
cord-332165-31tbc31x	222	27	space	space	NN
cord-332165-31tbc31x	222	28	for	for	IN
cord-332165-31tbc31x	222	29	linkers	linker	NNS
cord-332165-31tbc31x	222	30	and	and	CC
cord-332165-31tbc31x	222	31	a	a	DT
cord-332165-31tbc31x	222	32	central	central	JJ
cord-332165-31tbc31x	222	33	core	core	NN
cord-332165-31tbc31x	222	34	(	(	-LRB-
cord-332165-31tbc31x	222	35	Figure	figure	NN
cord-332165-31tbc31x	222	36	4a	4a	CD
cord-332165-31tbc31x	222	37	)	)	-RRB-
cord-332165-31tbc31x	222	38	.	.	.
cord-332165-31tbc31x	223	1	In	in	IN
cord-332165-31tbc31x	223	2	contrast	contrast	NN
cord-332165-31tbc31x	223	3	,	,	,
cord-332165-31tbc31x	223	4	the	the	DT
cord-332165-31tbc31x	223	5	sialic	sialic	JJ
cord-332165-31tbc31x	223	6	acid	acid	NN
cord-332165-31tbc31x	223	7	binding	bind	VBG
cord-332165-31tbc31x	223	8	sites	site	NNS
cord-332165-31tbc31x	223	9	of	of	IN
cord-332165-31tbc31x	223	10	the	the	DT
cord-332165-31tbc31x	223	11	reovirus	reovirus	NNP
cord-332165-31tbc31x	223	12	sigma	sigma	NNP
cord-332165-31tbc31x	223	13	1	1	CD
cord-332165-31tbc31x	223	14	fibers	fiber	NNS
cord-332165-31tbc31x	223	15	are	be	VBP
cord-332165-31tbc31x	223	16	located	locate	VBN
cord-332165-31tbc31x	223	17	on	on	IN
cord-332165-31tbc31x	223	18	the	the	DT
cord-332165-31tbc31x	223	19	side	side	NN
cord-332165-31tbc31x	223	20	of	of	IN
cord-332165-31tbc31x	223	21	the	the	DT
cord-332165-31tbc31x	223	22	protein	protein	NN
cord-332165-31tbc31x	223	23	(	(	-LRB-
cord-332165-31tbc31x	223	24	Figure	figure	NN
cord-332165-31tbc31x	223	25	4b	4b	CD
cord-332165-31tbc31x	223	26	)	)	-RRB-
cord-332165-31tbc31x	223	27	,	,	,
cord-332165-31tbc31x	223	28	which	which	WDT
cord-332165-31tbc31x	223	29	makes	make	VBZ
cord-332165-31tbc31x	223	30	it	-PRON-	PRP
cord-332165-31tbc31x	223	31	challenging	challenging	JJ
cord-332165-31tbc31x	223	32	to	to	TO
cord-332165-31tbc31x	223	33	design	design	VB
cord-332165-31tbc31x	223	34	an	an	DT
cord-332165-31tbc31x	223	35	appropriate	appropriate	JJ
cord-332165-31tbc31x	223	36	oligovalent	oligovalent	JJ
cord-332165-31tbc31x	223	37	inhibitor	inhibitor	NN
cord-332165-31tbc31x	223	38	.	.	.
cord-332165-31tbc31x	224	1	Additional	additional	JJ
cord-332165-31tbc31x	224	2	challenges	challenge	NNS
cord-332165-31tbc31x	224	3	are	be	VBP
cord-332165-31tbc31x	224	4	the	the	DT
cord-332165-31tbc31x	224	5	long	long	JJ
cord-332165-31tbc31x	224	6	-	-	HYPH
cord-332165-31tbc31x	224	7	term	term	NN
cord-332165-31tbc31x	224	8	stability	stability	NN
cord-332165-31tbc31x	224	9	,	,	,
cord-332165-31tbc31x	224	10	convenient	convenient	JJ
cord-332165-31tbc31x	224	11	synthesis	synthesis	NN
cord-332165-31tbc31x	224	12	,	,	,
cord-332165-31tbc31x	224	13	and	and	CC
cord-332165-31tbc31x	224	14	,	,	,
cord-332165-31tbc31x	224	15	for	for	IN
cord-332165-31tbc31x	224	16	later	later	JJ
cord-332165-31tbc31x	224	17	application	application	NN
cord-332165-31tbc31x	224	18	,	,	,
cord-332165-31tbc31x	224	19	reasonable	reasonable	JJ
cord-332165-31tbc31x	224	20	bioavailability	bioavailability	NN
cord-332165-31tbc31x	224	21	of	of	IN
cord-332165-31tbc31x	224	22	multivalent	multivalent	JJ
cord-332165-31tbc31x	224	23	compounds	compound	NNS
cord-332165-31tbc31x	224	24	.	.	.
cord-332165-31tbc31x	224	25	 	 	_SP
cord-332165-31tbc31x	225	1	N	N	NNP
cord-332165-31tbc31x	225	2	-	-	HYPH
cord-332165-31tbc31x	225	3	glycolylneuraminic	glycolylneuraminic	NN
cord-332165-31tbc31x	225	4	acid	acid	NN
cord-332165-31tbc31x	225	5	deficiency	deficiency	NN
cord-332165-31tbc31x	225	6	in	in	IN
cord-332165-31tbc31x	225	7	humans	human	NNS
cord-332165-31tbc31x	225	8	Chemical	Chemical	NNP
cord-332165-31tbc31x	225	9	Diversity	Diversity	NNP
cord-332165-31tbc31x	225	10	in	in	IN
cord-332165-31tbc31x	225	11	the	the	DT
cord-332165-31tbc31x	225	12	Sialic	Sialic	NNP
cord-332165-31tbc31x	225	13	Acids	Acids	NNPS
cord-332165-31tbc31x	225	14	and	and	CC
cord-332165-31tbc31x	225	15	Related	related	JJ
cord-332165-31tbc31x	225	16	α	α	NNP
cord-332165-31tbc31x	225	17	-	-	HYPH
cord-332165-31tbc31x	225	18	Keto	Keto	NNP
cord-332165-31tbc31x	225	19	Acids	acid	NNS
cord-332165-31tbc31x	225	20	:	:	:
cord-332165-31tbc31x	226	1	An	an	DT
cord-332165-31tbc31x	226	2	Evolutionary	Evolutionary	NNP
cord-332165-31tbc31x	226	3	Perspective	Perspective	NNP
cord-332165-31tbc31x	226	4	Diversity	diversity	NN
cord-332165-31tbc31x	226	5	in	in	IN
cord-332165-31tbc31x	226	6	cell	cell	NN
cord-332165-31tbc31x	226	7	surface	surface	NN
cord-332165-31tbc31x	226	8	sialic	sialic	NN
cord-332165-31tbc31x	226	9	acid	acid	NN
cord-332165-31tbc31x	226	10	presentations	presentation	NNS
cord-332165-31tbc31x	226	11	:	:	:
cord-332165-31tbc31x	226	12	Implications	implication	NNS
cord-332165-31tbc31x	226	13	for	for	IN
cord-332165-31tbc31x	226	14	biology	biology	NN
cord-332165-31tbc31x	226	15	and	and	CC
cord-332165-31tbc31x	226	16	disease	disease	NN
cord-332165-31tbc31x	226	17	Essentials	Essentials	NNPS
cord-332165-31tbc31x	226	18	of	of	IN
cord-332165-31tbc31x	226	19	Glycobiology	Glycobiology	NNP
cord-332165-31tbc31x	226	20	Sialic	Sialic	NNP
cord-332165-31tbc31x	226	21	acid	acid	JJ
cord-332165-31tbc31x	226	22	tissue	tissue	NN
cord-332165-31tbc31x	226	23	distribution	distribution	NN
cord-332165-31tbc31x	226	24	and	and	CC
cord-332165-31tbc31x	226	25	influenza	influenza	NN
cord-332165-31tbc31x	226	26	virus	virus	NN
cord-332165-31tbc31x	226	27	tropism	tropism	NN
cord-332165-31tbc31x	226	28	Structural	structural	JJ
cord-332165-31tbc31x	226	29	features	feature	NNS
cord-332165-31tbc31x	226	30	of	of	IN
cord-332165-31tbc31x	226	31	glycan	glycan	NN
cord-332165-31tbc31x	226	32	recognition	recognition	NN
cord-332165-31tbc31x	226	33	among	among	IN
cord-332165-31tbc31x	226	34	viral	viral	JJ
cord-332165-31tbc31x	226	35	pathogens	pathogen	NNS
cord-332165-31tbc31x	226	36	Glycan	Glycan	NNP
cord-332165-31tbc31x	226	37	Engagement	Engagement	NNP
cord-332165-31tbc31x	226	38	by	by	IN
cord-332165-31tbc31x	226	39	Viruses	virus	NNS
cord-332165-31tbc31x	226	40	:	:	:
cord-332165-31tbc31x	226	41	Receptor	receptor	NN
cord-332165-31tbc31x	226	42	Switches	Switches	NNPS
cord-332165-31tbc31x	226	43	and	and	CC
cord-332165-31tbc31x	226	44	Specificity	Specificity	NNP
cord-332165-31tbc31x	226	45	Human	Human	NNP
cord-332165-31tbc31x	226	46	and	and	CC
cord-332165-31tbc31x	226	47	bovine	bovine	JJ
cord-332165-31tbc31x	226	48	coronaviruses	coronaviruse	NNS
cord-332165-31tbc31x	226	49	recognize	recognize	VBP
cord-332165-31tbc31x	226	50	sialic	sialic	JJ
cord-332165-31tbc31x	226	51	acid	acid	NN
cord-332165-31tbc31x	226	52	-	-	HYPH
cord-332165-31tbc31x	226	53	containing	contain	VBG
cord-332165-31tbc31x	226	54	receptors	receptor	NNS
cord-332165-31tbc31x	226	55	similar	similar	JJ
cord-332165-31tbc31x	226	56	to	to	IN
cord-332165-31tbc31x	226	57	those	those	DT
cord-332165-31tbc31x	226	58	of	of	IN
cord-332165-31tbc31x	226	59	influenza	influenza	NN
cord-332165-31tbc31x	226	60	C	c	NN
cord-332165-31tbc31x	226	61	viruses	virus	NNS
cord-332165-31tbc31x	226	62	Sialic	sialic	VBP
cord-332165-31tbc31x	226	63	acids	acid	NNS
cord-332165-31tbc31x	226	64	as	as	IN
cord-332165-31tbc31x	226	65	receptor	receptor	NN
cord-332165-31tbc31x	226	66	determinants	determinant	NNS
cord-332165-31tbc31x	226	67	for	for	IN
cord-332165-31tbc31x	226	68	coronaviruses	coronaviruse	NNS
cord-332165-31tbc31x	226	69	Role	role	NN
cord-332165-31tbc31x	226	70	of	of	IN
cord-332165-31tbc31x	226	71	sialic	sialic	JJ
cord-332165-31tbc31x	226	72	acid	acid	NN
cord-332165-31tbc31x	226	73	-	-	HYPH
cord-332165-31tbc31x	226	74	containing	contain	VBG
cord-332165-31tbc31x	226	75	molecules	molecule	NNS
cord-332165-31tbc31x	226	76	in	in	IN
cord-332165-31tbc31x	226	77	paramyxovirus	paramyxovirus	JJ
cord-332165-31tbc31x	226	78	entry	entry	NN
cord-332165-31tbc31x	226	79	into	into	IN
cord-332165-31tbc31x	226	80	the	the	DT
cord-332165-31tbc31x	226	81	host	host	NN
cord-332165-31tbc31x	226	82	cell	cell	NN
cord-332165-31tbc31x	226	83	:	:	:
cord-332165-31tbc31x	227	1	A	a	DT
cord-332165-31tbc31x	227	2	minireview	minireview	NNP
cord-332165-31tbc31x	227	3	Structure	structure	NN
cord-332165-31tbc31x	227	4	of	of	IN
cord-332165-31tbc31x	227	5	the	the	DT
cord-332165-31tbc31x	227	6	influenza	influenza	NN
cord-332165-31tbc31x	227	7	virus	virus	NN
cord-332165-31tbc31x	227	8	haemagglutinin	haemagglutinin	NNP
cord-332165-31tbc31x	227	9	complexed	complexe	VBN
cord-332165-31tbc31x	227	10	with	with	IN
cord-332165-31tbc31x	227	11	its	-PRON-	PRP$
cord-332165-31tbc31x	227	12	receptor	receptor	NN
cord-332165-31tbc31x	227	13	,	,	,
cord-332165-31tbc31x	227	14	sialic	sialic	NN
cord-332165-31tbc31x	227	15	acid	acid	NN
cord-332165-31tbc31x	227	16	Sialic	Sialic	NNP
cord-332165-31tbc31x	227	17	Acid	Acid	NNP
cord-332165-31tbc31x	227	18	Species	Species	NNP
cord-332165-31tbc31x	227	19	as	as	IN
cord-332165-31tbc31x	227	20	a	a	DT
cord-332165-31tbc31x	227	21	Determinant	determinant	NN
cord-332165-31tbc31x	227	22	of	of	IN
cord-332165-31tbc31x	227	23	the	the	DT
cord-332165-31tbc31x	227	24	Host	Host	NNP
cord-332165-31tbc31x	227	25	Range	Range	NNP
cord-332165-31tbc31x	227	26	of	of	IN
cord-332165-31tbc31x	227	27	Influenza	Influenza	NNP
cord-332165-31tbc31x	227	28	A	A	NNP
cord-332165-31tbc31x	227	29	Viruses	virus	NNS
cord-332165-31tbc31x	227	30	Binding	Binding	NNP
cord-332165-31tbc31x	227	31	of	of	IN
cord-332165-31tbc31x	227	32	Adeno	Adeno	NNP
cord-332165-31tbc31x	227	33	-	-	HYPH
cord-332165-31tbc31x	227	34	associated	associate	VBN
cord-332165-31tbc31x	227	35	Virus	Virus	NNP
cord-332165-31tbc31x	227	36	Type	type	NN
cord-332165-31tbc31x	228	1	5	5	CD
cord-332165-31tbc31x	228	2	to	to	IN
cord-332165-31tbc31x	228	3	2,3-Linked	2,3-linked	CD
cord-332165-31tbc31x	229	1	Sialic	Sialic	NNP
cord-332165-31tbc31x	229	2	Acid	acid	NN
cord-332165-31tbc31x	229	3	Is	be	VBZ
cord-332165-31tbc31x	229	4	Required	require	VBN
cord-332165-31tbc31x	229	5	for	for	IN
cord-332165-31tbc31x	229	6	Gene	Gene	NNP
cord-332165-31tbc31x	229	7	Transfer	Transfer	NNP
cord-332165-31tbc31x	229	8	Adeno	Adeno	NNP
cord-332165-31tbc31x	229	9	-	-	HYPH
cord-332165-31tbc31x	229	10	Associated	Associated	NNP
cord-332165-31tbc31x	229	11	Virus	Virus	NNP
cord-332165-31tbc31x	229	12	Serotype	Serotype	NNP
cord-332165-31tbc31x	229	13	4	4	CD
cord-332165-31tbc31x	229	14	(	(	-LRB-
cord-332165-31tbc31x	229	15	AAV4	AAV4	NNP
cord-332165-31tbc31x	229	16	)	)	-RRB-
cord-332165-31tbc31x	229	17	and	and	CC
cord-332165-31tbc31x	229	18	AAV5	AAV5	NNP
cord-332165-31tbc31x	230	1	Both	both	DT
cord-332165-31tbc31x	230	2	Require	require	VB
cord-332165-31tbc31x	230	3	Sialic	Sialic	NNP
cord-332165-31tbc31x	230	4	Acid	acid	NN
cord-332165-31tbc31x	230	5	Binding	Binding	NNP
cord-332165-31tbc31x	230	6	for	for	IN
cord-332165-31tbc31x	230	7	Hemagglutination	Hemagglutination	NNP
cord-332165-31tbc31x	230	8	and	and	CC
cord-332165-31tbc31x	230	9	Efficient	Efficient	NNP
cord-332165-31tbc31x	230	10	Transduction	transduction	NN
cord-332165-31tbc31x	230	11	but	but	CC
cord-332165-31tbc31x	230	12	Differ	differ	VBP
cord-332165-31tbc31x	230	13	in	in	IN
cord-332165-31tbc31x	230	14	Sialic	Sialic	NNP
cord-332165-31tbc31x	230	15	Acid	Acid	NNP
cord-332165-31tbc31x	230	16	Linkage	linkage	NN
cord-332165-31tbc31x	230	17	Specificity	Specificity	NNP
cord-332165-31tbc31x	230	18	Sialic	Sialic	NNP
cord-332165-31tbc31x	230	19	Acid	Acid	NNP
cord-332165-31tbc31x	230	20	Functions	Functions	NNPS
cord-332165-31tbc31x	230	21	in	in	IN
cord-332165-31tbc31x	230	22	Enterovirus	enterovirus	NN
cord-332165-31tbc31x	231	1	70	70	CD
cord-332165-31tbc31x	231	2	Binding	Binding	NNP
cord-332165-31tbc31x	231	3	and	and	CC
cord-332165-31tbc31x	231	4	Infection	Infection	NNP
cord-332165-31tbc31x	231	5	Coxsackievirus	Coxsackievirus	NNP
cord-332165-31tbc31x	231	6	A24	A24	NNP
cord-332165-31tbc31x	231	7	Variant	variant	NN
cord-332165-31tbc31x	231	8	Uses	use	VBZ
cord-332165-31tbc31x	231	9	Sialic	Sialic	NNP
cord-332165-31tbc31x	231	10	Acid	acid	NN
cord-332165-31tbc31x	231	11	-	-	HYPH
cord-332165-31tbc31x	231	12	Containing	contain	VBG
cord-332165-31tbc31x	231	13	O	o	NN
cord-332165-31tbc31x	231	14	-	-	HYPH
cord-332165-31tbc31x	231	15	Linked	link	VBN
cord-332165-31tbc31x	231	16	Glycoconjugates	Glycoconjugates	NNPS
cord-332165-31tbc31x	231	17	as	as	IN
cord-332165-31tbc31x	231	18	Cellular	Cellular	NNP
cord-332165-31tbc31x	231	19	Receptors	Receptors	NNPS
cord-332165-31tbc31x	231	20	on	on	IN
cord-332165-31tbc31x	231	21	Human	Human	NNP
cord-332165-31tbc31x	231	22	Ocular	Ocular	NNP
cord-332165-31tbc31x	231	23	Cells	Cells	NNPS
cord-332165-31tbc31x	232	1	Sialic	Sialic	NNP
cord-332165-31tbc31x	232	2	acid	acid	NN
cord-332165-31tbc31x	232	3	-	-	HYPH
cord-332165-31tbc31x	232	4	dependent	dependent	JJ
cord-332165-31tbc31x	232	5	cell	cell	NN
cord-332165-31tbc31x	232	6	entry	entry	NN
cord-332165-31tbc31x	232	7	of	of	IN
cord-332165-31tbc31x	232	8	human	human	JJ
cord-332165-31tbc31x	232	9	enterovirus	enterovirus	NN
cord-332165-31tbc31x	232	10	D68	D68	NNP
cord-332165-31tbc31x	232	11	Tulane	Tulane	NNP
cord-332165-31tbc31x	232	12	virus	virus	NN
cord-332165-31tbc31x	232	13	recognizes	recognize	VBZ
cord-332165-31tbc31x	232	14	sialic	sialic	JJ
cord-332165-31tbc31x	232	15	acids	acid	NNS
cord-332165-31tbc31x	232	16	as	as	IN
cord-332165-31tbc31x	232	17	cellular	cellular	JJ
cord-332165-31tbc31x	232	18	receptors	receptor	NNS
cord-332165-31tbc31x	232	19	Infection	infection	NN
cord-332165-31tbc31x	232	20	of	of	IN
cord-332165-31tbc31x	232	21	Glial	Glial	NNP
cord-332165-31tbc31x	232	22	Cells	cell	NNS
cord-332165-31tbc31x	232	23	by	by	IN
cord-332165-31tbc31x	232	24	the	the	DT
cord-332165-31tbc31x	232	25	Human	Human	NNP
cord-332165-31tbc31x	232	26	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	232	27	JC	JC	NNP
cord-332165-31tbc31x	232	28	Is	be	VBZ
cord-332165-31tbc31x	232	29	Mediated	mediate	VBN
cord-332165-31tbc31x	232	30	by	by	IN
cord-332165-31tbc31x	232	31	an	an	DT
cord-332165-31tbc31x	232	32	N	N	NNP
cord-332165-31tbc31x	232	33	-	-	HYPH
cord-332165-31tbc31x	232	34	Linked	link	VBN
cord-332165-31tbc31x	232	35	Glycoprotein	Glycoprotein	NNP
cord-332165-31tbc31x	232	36	Containing	Containing	NNP
cord-332165-31tbc31x	232	37	Terminal	Terminal	NNP
cord-332165-31tbc31x	232	38	α(2	α(2	NFP
cord-332165-31tbc31x	233	1	-6)-Linked	-6)-Linked	NNP
cord-332165-31tbc31x	233	2	Sialic	Sialic	NNP
cord-332165-31tbc31x	233	3	Acids	Acids	NNPS
cord-332165-31tbc31x	233	4	Gangliosides	Gangliosides	NNPS
cord-332165-31tbc31x	233	5	are	be	VBP
cord-332165-31tbc31x	233	6	receptors	receptor	NNS
cord-332165-31tbc31x	233	7	for	for	IN
cord-332165-31tbc31x	233	8	murine	murine	JJ
cord-332165-31tbc31x	233	9	polyoma	polyoma	NN
cord-332165-31tbc31x	233	10	virus	virus	NN
cord-332165-31tbc31x	233	11	and	and	CC
cord-332165-31tbc31x	233	12	SV40	SV40	NNP
cord-332165-31tbc31x	233	13	Identification	Identification	NNP
cord-332165-31tbc31x	233	14	of	of	IN
cord-332165-31tbc31x	233	15	Gangliosides	Gangliosides	NNP
cord-332165-31tbc31x	233	16	GD1b	GD1b	NNP
cord-332165-31tbc31x	233	17	and	and	CC
cord-332165-31tbc31x	233	18	GT1b	GT1b	NNP
cord-332165-31tbc31x	233	19	as	as	IN
cord-332165-31tbc31x	233	20	Receptors	Receptors	NNPS
cord-332165-31tbc31x	233	21	for	for	IN
cord-332165-31tbc31x	233	22	BK	BK	NNP
cord-332165-31tbc31x	233	23	Virus	Virus	NNP
cord-332165-31tbc31x	233	24	Ganglioside	Ganglioside	NNP
cord-332165-31tbc31x	233	25	GT1b	GT1b	NNP
cord-332165-31tbc31x	234	1	Is	be	VBZ
cord-332165-31tbc31x	234	2	a	a	DT
cord-332165-31tbc31x	234	3	Putative	Putative	NNP
cord-332165-31tbc31x	234	4	Host	Host	NNP
cord-332165-31tbc31x	234	5	Cell	Cell	NNP
cord-332165-31tbc31x	234	6	Receptor	Receptor	NNP
cord-332165-31tbc31x	234	7	for	for	IN
cord-332165-31tbc31x	234	8	the	the	DT
cord-332165-31tbc31x	234	9	Merkel	Merkel	NNP
cord-332165-31tbc31x	234	10	Cell	Cell	NNP
cord-332165-31tbc31x	234	11	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	235	1	The	the	DT
cord-332165-31tbc31x	235	2	α	α	NN
cord-332165-31tbc31x	235	3	-	-	HYPH
cord-332165-31tbc31x	235	4	anomeric	anomeric	NN
cord-332165-31tbc31x	235	5	form	form	NN
cord-332165-31tbc31x	235	6	of	of	IN
cord-332165-31tbc31x	235	7	sialic	sialic	JJ
cord-332165-31tbc31x	235	8	acid	acid	NN
cord-332165-31tbc31x	235	9	is	be	VBZ
cord-332165-31tbc31x	235	10	the	the	DT
cord-332165-31tbc31x	235	11	minimal	minimal	JJ
cord-332165-31tbc31x	235	12	receptor	receptor	NN
cord-332165-31tbc31x	235	13	determinant	determinant	NN
cord-332165-31tbc31x	235	14	recognized	recognize	VBN
cord-332165-31tbc31x	235	15	by	by	IN
cord-332165-31tbc31x	235	16	reovirus	reovirus	NNP
cord-332165-31tbc31x	235	17	Initial	Initial	NNP
cord-332165-31tbc31x	235	18	Interaction	Interaction	NNP
cord-332165-31tbc31x	235	19	of	of	IN
cord-332165-31tbc31x	235	20	Rotavirus	Rotavirus	NNP
cord-332165-31tbc31x	235	21	Strains	Strains	NNPS
cord-332165-31tbc31x	235	22	with	with	IN
cord-332165-31tbc31x	235	23	N	n	CD
cord-332165-31tbc31x	235	24	-	-	HYPH
cord-332165-31tbc31x	235	25	Acetylneuraminic	Acetylneuraminic	NNP
cord-332165-31tbc31x	235	26	(	(	-LRB-
cord-332165-31tbc31x	235	27	Sialic	Sialic	NNP
cord-332165-31tbc31x	235	28	)	)	-RRB-
cord-332165-31tbc31x	235	29	Acid	acid	NN
cord-332165-31tbc31x	235	30	Residues	residue	NNS
cord-332165-31tbc31x	235	31	on	on	IN
cord-332165-31tbc31x	235	32	the	the	DT
cord-332165-31tbc31x	235	33	Cell	Cell	NNP
cord-332165-31tbc31x	235	34	Surface	surface	NN
cord-332165-31tbc31x	235	35	Correlates	correlate	VBZ
cord-332165-31tbc31x	235	36	with	with	IN
cord-332165-31tbc31x	235	37	VP4	VP4	NNP
cord-332165-31tbc31x	235	38	Genotype	Genotype	NNP
cord-332165-31tbc31x	235	39	,	,	,
cord-332165-31tbc31x	235	40	Not	not	RB
cord-332165-31tbc31x	235	41	Species	specie	NNS
cord-332165-31tbc31x	235	42	of	of	IN
cord-332165-31tbc31x	235	43	Origin	Origin	NNP
cord-332165-31tbc31x	235	44	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	235	45	Type	Type	NNP
cord-332165-31tbc31x	235	46	37	37	CD
cord-332165-31tbc31x	235	47	Uses	use	VBZ
cord-332165-31tbc31x	235	48	Sialic	Sialic	NNP
cord-332165-31tbc31x	235	49	Acid	Acid	NNP
cord-332165-31tbc31x	235	50	as	as	IN
cord-332165-31tbc31x	235	51	a	a	DT
cord-332165-31tbc31x	235	52	Cellular	Cellular	NNP
cord-332165-31tbc31x	235	53	Receptor	Receptor	NNP
cord-332165-31tbc31x	235	54	Human	Human	NNP
cord-332165-31tbc31x	235	55	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	235	56	52	52	CD
cord-332165-31tbc31x	236	1	Uses	use	VBZ
cord-332165-31tbc31x	236	2	Sialic	Sialic	NNP
cord-332165-31tbc31x	236	3	Acid	acid	NN
cord-332165-31tbc31x	236	4	-	-	HYPH
cord-332165-31tbc31x	236	5	containing	contain	VBG
cord-332165-31tbc31x	236	6	Glycoproteins	Glycoproteins	NNP
cord-332165-31tbc31x	236	7	and	and	CC
cord-332165-31tbc31x	236	8	the	the	DT
cord-332165-31tbc31x	236	9	Coxsackie	Coxsackie	NNP
cord-332165-31tbc31x	236	10	and	and	CC
cord-332165-31tbc31x	236	11	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	236	12	Receptor	Receptor	NNP
cord-332165-31tbc31x	236	13	for	for	IN
cord-332165-31tbc31x	236	14	Binding	bind	VBG
cord-332165-31tbc31x	236	15	to	to	TO
cord-332165-31tbc31x	236	16	Target	target	VB
cord-332165-31tbc31x	236	17	Cells	cell	NNS
cord-332165-31tbc31x	237	1	Structural	structural	JJ
cord-332165-31tbc31x	237	2	basis	basis	NN
cord-332165-31tbc31x	237	3	of	of	IN
cord-332165-31tbc31x	237	4	GM1	GM1	NNP
cord-332165-31tbc31x	237	5	ganglioside	ganglioside	NN
cord-332165-31tbc31x	237	6	recognition	recognition	NN
cord-332165-31tbc31x	237	7	by	by	IN
cord-332165-31tbc31x	237	8	simian	simian	JJ
cord-332165-31tbc31x	237	9	virus	virus	NN
cord-332165-31tbc31x	237	10	40	40	CD
cord-332165-31tbc31x	237	11	Structural	structural	JJ
cord-332165-31tbc31x	237	12	and	and	CC
cord-332165-31tbc31x	237	13	Functional	Functional	NNP
cord-332165-31tbc31x	237	14	Analysis	Analysis	NNP
cord-332165-31tbc31x	237	15	of	of	IN
cord-332165-31tbc31x	237	16	Murine	Murine	NNP
cord-332165-31tbc31x	237	17	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	237	18	Capsid	Capsid	NNP
cord-332165-31tbc31x	237	19	Proteins	protein	NNS
cord-332165-31tbc31x	237	20	Establish	establish	VBP
cord-332165-31tbc31x	237	21	the	the	DT
cord-332165-31tbc31x	237	22	Determinants	determinant	NNS
cord-332165-31tbc31x	237	23	of	of	IN
cord-332165-31tbc31x	237	24	Ligand	Ligand	NNP
cord-332165-31tbc31x	237	25	Recognition	Recognition	NNP
cord-332165-31tbc31x	237	26	and	and	CC
cord-332165-31tbc31x	237	27	Pathogenicity	Pathogenicity	NNP
cord-332165-31tbc31x	237	28	Triazole	Triazole	NNP
cord-332165-31tbc31x	237	29	linker	linker	NN
cord-332165-31tbc31x	237	30	-	-	HYPH
cord-332165-31tbc31x	237	31	based	base	VBN
cord-332165-31tbc31x	237	32	trivalent	trivalent	JJ
cord-332165-31tbc31x	237	33	sialic	sialic	NN
cord-332165-31tbc31x	237	34	acid	acid	NN
cord-332165-31tbc31x	237	35	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	237	36	of	of	IN
cord-332165-31tbc31x	237	37	adenovirus	adenovirus	NN
cord-332165-31tbc31x	237	38	type	type	NN
cord-332165-31tbc31x	237	39	37	37	CD
cord-332165-31tbc31x	237	40	infection	infection	NN
cord-332165-31tbc31x	237	41	of	of	IN
cord-332165-31tbc31x	237	42	human	human	JJ
cord-332165-31tbc31x	237	43	corneal	corneal	JJ
cord-332165-31tbc31x	237	44	epithelial	epithelial	JJ
cord-332165-31tbc31x	237	45	cells	cell	NNS
cord-332165-31tbc31x	238	1	Hemagglutinins	Hemagglutinins	NNP
cord-332165-31tbc31x	238	2	from	from	IN
cord-332165-31tbc31x	238	3	two	two	CD
cord-332165-31tbc31x	238	4	influenza	influenza	NN
cord-332165-31tbc31x	238	5	virus	virus	NN
cord-332165-31tbc31x	238	6	variants	variant	NNS
cord-332165-31tbc31x	238	7	bind	bind	VBP
cord-332165-31tbc31x	238	8	to	to	IN
cord-332165-31tbc31x	238	9	sialic	sialic	JJ
cord-332165-31tbc31x	238	10	acid	acid	NN
cord-332165-31tbc31x	238	11	derivatives	derivative	NNS
cord-332165-31tbc31x	238	12	with	with	IN
cord-332165-31tbc31x	238	13	millimolar	millimolar	JJ
cord-332165-31tbc31x	238	14	dissociation	dissociation	NN
cord-332165-31tbc31x	238	15	constants	constant	NNS
cord-332165-31tbc31x	238	16	:	:	:
cord-332165-31tbc31x	239	1	A	a	DT
cord-332165-31tbc31x	239	2	500-MHz	500-mhz	CD
cord-332165-31tbc31x	239	3	proton	proton	NN
cord-332165-31tbc31x	239	4	nuclear	nuclear	JJ
cord-332165-31tbc31x	239	5	magnetic	magnetic	JJ
cord-332165-31tbc31x	239	6	resonance	resonance	NN
cord-332165-31tbc31x	239	7	study	study	NN
cord-332165-31tbc31x	240	1	Globotriosyl	globotriosyl	JJ
cord-332165-31tbc31x	240	2	ceramide	ceramide	NN
cord-332165-31tbc31x	240	3	is	be	VBZ
cord-332165-31tbc31x	240	4	specifically	specifically	RB
cord-332165-31tbc31x	240	5	recognized	recognize	VBN
cord-332165-31tbc31x	240	6	by	by	IN
cord-332165-31tbc31x	240	7	the	the	DT
cord-332165-31tbc31x	240	8	escherichia	escherichia	NNP
cord-332165-31tbc31x	240	9	coli	coli	NNP
cord-332165-31tbc31x	240	10	verocytotoxin	verocytotoxin	NNP
cord-332165-31tbc31x	240	11	2	2	CD
cord-332165-31tbc31x	240	12	Structure	Structure	NNP
cord-332165-31tbc31x	240	13	of	of	IN
cord-332165-31tbc31x	240	14	the	the	DT
cord-332165-31tbc31x	240	15	Shiga	Shiga	NNP
cord-332165-31tbc31x	240	16	-	-	HYPH
cord-332165-31tbc31x	240	17	like	like	JJ
cord-332165-31tbc31x	240	18	Toxin	toxin	NN
cord-332165-31tbc31x	240	19	I	I	NNP
cord-332165-31tbc31x	240	20	B	B	NNP
cord-332165-31tbc31x	240	21	-	-	HYPH
cord-332165-31tbc31x	240	22	Pentamer	Pentamer	NNP
cord-332165-31tbc31x	240	23	Complexed	Complexed	NNP
cord-332165-31tbc31x	240	24	with	with	IN
cord-332165-31tbc31x	240	25	an	an	DT
cord-332165-31tbc31x	240	26	Analogue	Analogue	NNP
cord-332165-31tbc31x	240	27	of	of	IN
cord-332165-31tbc31x	240	28	Its	-PRON-	PRP$
cord-332165-31tbc31x	240	29	Receptor	Receptor	NNP
cord-332165-31tbc31x	240	30	Gb3	gb3	NN
cord-332165-31tbc31x	241	1	Shiga	Shiga	NNP
cord-332165-31tbc31x	241	2	-	-	HYPH
cord-332165-31tbc31x	241	3	like	like	JJ
cord-332165-31tbc31x	241	4	toxins	toxin	NNS
cord-332165-31tbc31x	241	5	are	be	VBP
cord-332165-31tbc31x	241	6	neutralized	neutralize	VBN
cord-332165-31tbc31x	241	7	by	by	IN
cord-332165-31tbc31x	241	8	tailored	tailor	VBN
cord-332165-31tbc31x	241	9	multivalent	multivalent	JJ
cord-332165-31tbc31x	241	10	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	241	11	ligands	ligand	NNS
cord-332165-31tbc31x	241	12	Physical	Physical	NNP
cord-332165-31tbc31x	241	13	Principles	Principles	NNPS
cord-332165-31tbc31x	241	14	in	in	IN
cord-332165-31tbc31x	241	15	the	the	DT
cord-332165-31tbc31x	241	16	Construction	Construction	NNP
cord-332165-31tbc31x	241	17	of	of	IN
cord-332165-31tbc31x	241	18	Regular	Regular	NNP
cord-332165-31tbc31x	241	19	Viruses	Viruses	NNPS
cord-332165-31tbc31x	241	20	Characterization	characterization	NN
cord-332165-31tbc31x	241	21	of	of	IN
cord-332165-31tbc31x	241	22	the	the	DT
cord-332165-31tbc31x	241	23	Adeno	Adeno	NNP
cord-332165-31tbc31x	241	24	-	-	HYPH
cord-332165-31tbc31x	241	25	Associated	Associated	NNP
cord-332165-31tbc31x	241	26	Virus	Virus	NNP
cord-332165-31tbc31x	241	27	1	1	CD
cord-332165-31tbc31x	241	28	and	and	CC
cord-332165-31tbc31x	241	29	6	6	CD
cord-332165-31tbc31x	241	30	Sialic	Sialic	NNP
cord-332165-31tbc31x	241	31	Acid	acid	NN
cord-332165-31tbc31x	241	32	Binding	binding	NN
cord-332165-31tbc31x	241	33	Site	site	NN
cord-332165-31tbc31x	242	1	A	a	DT
cord-332165-31tbc31x	242	2	Sialic	Sialic	NNP
cord-332165-31tbc31x	242	3	Acid	acid	NN
cord-332165-31tbc31x	242	4	Binding	Binding	NNP
cord-332165-31tbc31x	242	5	Site	site	NN
cord-332165-31tbc31x	242	6	in	in	IN
cord-332165-31tbc31x	242	7	a	a	DT
cord-332165-31tbc31x	242	8	Human	Human	NNP
cord-332165-31tbc31x	242	9	Picornavirus	Picornavirus	NNP
cord-332165-31tbc31x	242	10	Atomic	Atomic	NNP
cord-332165-31tbc31x	242	11	model	model	NN
cord-332165-31tbc31x	242	12	of	of	IN
cord-332165-31tbc31x	242	13	the	the	DT
cord-332165-31tbc31x	242	14	papillomavirus	papillomavirus	NN
cord-332165-31tbc31x	242	15	capsid	capsid	NN
cord-332165-31tbc31x	242	16	Polyoma	Polyoma	NNP
cord-332165-31tbc31x	242	17	virus	virus	NN
cord-332165-31tbc31x	242	18	capsid	capsid	NN
cord-332165-31tbc31x	242	19	structure	structure	NN
cord-332165-31tbc31x	242	20	at	at	IN
cord-332165-31tbc31x	242	21	22.5	22.5	CD
cord-332165-31tbc31x	242	22	.	.	.
cord-332165-31tbc31x	243	1	A	a	DT
cord-332165-31tbc31x	243	2	resolution	resolution	NN
cord-332165-31tbc31x	243	3	Structure	structure	NN
cord-332165-31tbc31x	243	4	of	of	IN
cord-332165-31tbc31x	243	5	simian	simian	JJ
cord-332165-31tbc31x	243	6	virus	virus	NN
cord-332165-31tbc31x	243	7	40	40	CD
cord-332165-31tbc31x	243	8	at	at	IN
cord-332165-31tbc31x	243	9	3.8-Å	3.8-å	CD
cord-332165-31tbc31x	243	10	resolution	resolution	NN
cord-332165-31tbc31x	243	11	Structure	Structure	NNP
cord-332165-31tbc31x	243	12	of	of	IN
cord-332165-31tbc31x	243	13	Small	Small	NNP
cord-332165-31tbc31x	243	14	Virus	Virus	NNP
cord-332165-31tbc31x	243	15	-	-	HYPH
cord-332165-31tbc31x	243	16	like	like	JJ
cord-332165-31tbc31x	243	17	Particles	particle	NNS
cord-332165-31tbc31x	243	18	Assembled	assemble	VBN
cord-332165-31tbc31x	243	19	from	from	IN
cord-332165-31tbc31x	243	20	the	the	DT
cord-332165-31tbc31x	243	21	L1	L1	NNP
cord-332165-31tbc31x	243	22	Protein	Protein	NNP
cord-332165-31tbc31x	243	23	of	of	IN
cord-332165-31tbc31x	243	24	Human	Human	NNP
cord-332165-31tbc31x	243	25	Papillomavirus	Papillomavirus	NNP
cord-332165-31tbc31x	243	26	16	16	CD
cord-332165-31tbc31x	243	27	Polymorphism	Polymorphism	NNP
cord-332165-31tbc31x	243	28	in	in	IN
cord-332165-31tbc31x	243	29	the	the	DT
cord-332165-31tbc31x	243	30	assembly	assembly	NNP
cord-332165-31tbc31x	243	31	of	of	IN
cord-332165-31tbc31x	243	32	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	243	33	capsid	capsid	NNP
cord-332165-31tbc31x	243	34	protein	protein	NN
cord-332165-31tbc31x	243	35	VP1	VP1	NNP
cord-332165-31tbc31x	243	36	Structure	Structure	NNP
cord-332165-31tbc31x	243	37	and	and	CC
cord-332165-31tbc31x	243	38	Assembly	Assembly	NNP
cord-332165-31tbc31x	243	39	of	of	IN
cord-332165-31tbc31x	243	40	a	a	DT
cord-332165-31tbc31x	243	41	T	t	NN
cord-332165-31tbc31x	243	42	=	=	SYM
cord-332165-31tbc31x	243	43	1	1	CD
cord-332165-31tbc31x	243	44	Virus	Virus	NNP
cord-332165-31tbc31x	243	45	-	-	:
cord-332165-31tbc31x	243	46	Like	Like	NNP
cord-332165-31tbc31x	243	47	Particle	Particle	NNP
cord-332165-31tbc31x	243	48	in	in	IN
cord-332165-31tbc31x	243	49	BK	BK	NNP
cord-332165-31tbc31x	243	50	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	243	51	High	High	NNP
cord-332165-31tbc31x	243	52	-	-	HYPH
cord-332165-31tbc31x	243	53	resolution	resolution	NN
cord-332165-31tbc31x	243	54	structure	structure	NN
cord-332165-31tbc31x	243	55	of	of	IN
cord-332165-31tbc31x	243	56	a	a	DT
cord-332165-31tbc31x	243	57	polyomavirus	polyomavirus	JJ
cord-332165-31tbc31x	243	58	VP1-oligosaccharide	vp1-oligosaccharide	NN
cord-332165-31tbc31x	243	59	complex	complex	JJ
cord-332165-31tbc31x	243	60	:	:	:
cord-332165-31tbc31x	243	61	Implications	implication	NNS
cord-332165-31tbc31x	243	62	for	for	IN
cord-332165-31tbc31x	243	63	assembly	assembly	NN
cord-332165-31tbc31x	243	64	and	and	CC
cord-332165-31tbc31x	243	65	receptor	receptor	NN
cord-332165-31tbc31x	243	66	binding	bind	VBG
cord-332165-31tbc31x	243	67	Structure	structure	NN
cord-332165-31tbc31x	243	68	-	-	HYPH
cord-332165-31tbc31x	243	69	function	function	NN
cord-332165-31tbc31x	243	70	analysis	analysis	NN
cord-332165-31tbc31x	243	71	of	of	IN
cord-332165-31tbc31x	243	72	the	the	DT
cord-332165-31tbc31x	243	73	human	human	JJ
cord-332165-31tbc31x	243	74	JC	JC	NNP
cord-332165-31tbc31x	243	75	polyomavirus	polyomavirus	NNP
cord-332165-31tbc31x	243	76	establishes	establish	VBZ
cord-332165-31tbc31x	243	77	the	the	DT
cord-332165-31tbc31x	243	78	LSTc	LSTc	NNS
cord-332165-31tbc31x	243	79	pentasaccharide	pentasaccharide	NNP
cord-332165-31tbc31x	243	80	as	as	IN
cord-332165-31tbc31x	243	81	a	a	DT
cord-332165-31tbc31x	243	82	functional	functional	JJ
cord-332165-31tbc31x	243	83	receptor	receptor	NN
cord-332165-31tbc31x	243	84	motif	motif	NN
cord-332165-31tbc31x	243	85	Structures	structure	NNS
cord-332165-31tbc31x	243	86	of	of	IN
cord-332165-31tbc31x	243	87	Merkel	Merkel	NNP
cord-332165-31tbc31x	243	88	Cell	Cell	NNP
cord-332165-31tbc31x	243	89	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	243	90	VP1	VP1	NNP
cord-332165-31tbc31x	243	91	Complexes	complex	NNS
cord-332165-31tbc31x	243	92	Define	define	VBP
cord-332165-31tbc31x	243	93	a	a	DT
cord-332165-31tbc31x	243	94	Sialic	sialic	NN
cord-332165-31tbc31x	243	95	Acid	acid	NN
cord-332165-31tbc31x	243	96	Binding	binding	NN
cord-332165-31tbc31x	243	97	Site	site	NN
cord-332165-31tbc31x	243	98	Required	require	VBN
cord-332165-31tbc31x	243	99	for	for	IN
cord-332165-31tbc31x	243	100	Infection	Infection	NNP
cord-332165-31tbc31x	243	101	A	A	NNP
cord-332165-31tbc31x	243	102	Structure	Structure	NNP
cord-332165-31tbc31x	243	103	-	-	HYPH
cord-332165-31tbc31x	243	104	Guided	Guided	NNP
cord-332165-31tbc31x	243	105	Mutation	Mutation	NNP
cord-332165-31tbc31x	243	106	in	in	IN
cord-332165-31tbc31x	243	107	the	the	DT
cord-332165-31tbc31x	243	108	Major	Major	NNP
cord-332165-31tbc31x	243	109	Capsid	Capsid	NNP
cord-332165-31tbc31x	243	110	Protein	Protein	NNP
cord-332165-31tbc31x	243	111	Retargets	Retargets	NNP
cord-332165-31tbc31x	243	112	BK	BK	NNP
cord-332165-31tbc31x	243	113	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	243	114	Structures	structure	NNS
cord-332165-31tbc31x	243	115	of	of	IN
cord-332165-31tbc31x	243	116	B	B	NNP
cord-332165-31tbc31x	243	117	-	-	HYPH
cord-332165-31tbc31x	243	118	Lymphotropic	Lymphotropic	NNP
cord-332165-31tbc31x	243	119	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	243	120	VP1	vp1	NN
cord-332165-31tbc31x	243	121	in	in	IN
cord-332165-31tbc31x	243	122	Complex	Complex	NNP
cord-332165-31tbc31x	243	123	with	with	IN
cord-332165-31tbc31x	243	124	Oligosaccharide	Oligosaccharide	NNP
cord-332165-31tbc31x	244	1	Ligands	Ligands	NNP
cord-332165-31tbc31x	244	2	Crystallographic	Crystallographic	NNP
cord-332165-31tbc31x	244	3	and	and	CC
cord-332165-31tbc31x	244	4	Glycan	Glycan	NNP
cord-332165-31tbc31x	244	5	Microarray	Microarray	NNP
cord-332165-31tbc31x	244	6	Analysis	Analysis	NNP
cord-332165-31tbc31x	244	7	of	of	IN
cord-332165-31tbc31x	244	8	Human	Human	NNP
cord-332165-31tbc31x	244	9	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	244	10	9	9	CD
cord-332165-31tbc31x	244	11	VP1	VP1	NNP
cord-332165-31tbc31x	244	12	Identifies	identify	VBZ
cord-332165-31tbc31x	244	13	N	N	NNP
cord-332165-31tbc31x	244	14	-	-	HYPH
cord-332165-31tbc31x	244	15	Glycolyl	Glycolyl	NNP
cord-332165-31tbc31x	244	16	Neuraminic	Neuraminic	NNP
cord-332165-31tbc31x	244	17	Acid	Acid	NNP
cord-332165-31tbc31x	244	18	as	as	IN
cord-332165-31tbc31x	244	19	a	a	DT
cord-332165-31tbc31x	244	20	Receptor	Receptor	NNP
cord-332165-31tbc31x	244	21	Candidate	Candidate	NNP
cord-332165-31tbc31x	244	22	Trichodysplasia	Trichodysplasia	NNP
cord-332165-31tbc31x	244	23	spinulosa	spinulosa	NNP
cord-332165-31tbc31x	244	24	-	-	HYPH
cord-332165-31tbc31x	244	25	Associated	Associated	NNP
cord-332165-31tbc31x	244	26	Polyomavirus	Polyomavirus	NNP
cord-332165-31tbc31x	244	27	Uses	use	VBZ
cord-332165-31tbc31x	244	28	a	a	DT
cord-332165-31tbc31x	244	29	Displaced	displace	VBN
cord-332165-31tbc31x	244	30	Binding	Binding	NNP
cord-332165-31tbc31x	244	31	Site	site	NN
cord-332165-31tbc31x	244	32	on	on	IN
cord-332165-31tbc31x	244	33	VP1	vp1	NN
cord-332165-31tbc31x	244	34	to	to	TO
cord-332165-31tbc31x	244	35	Engage	engage	VB
cord-332165-31tbc31x	244	36	Sialylated	Sialylated	NNP
cord-332165-31tbc31x	244	37	Glycolipids	Glycolipids	NNP
cord-332165-31tbc31x	245	1	The	the	DT
cord-332165-31tbc31x	245	2	L1	L1	NNP
cord-332165-31tbc31x	245	3	Major	Major	NNP
cord-332165-31tbc31x	245	4	Capsid	Capsid	NNP
cord-332165-31tbc31x	245	5	Protein	Protein	NNP
cord-332165-31tbc31x	245	6	of	of	IN
cord-332165-31tbc31x	245	7	Human	Human	NNP
cord-332165-31tbc31x	245	8	Papillomavirus	Papillomavirus	NNP
cord-332165-31tbc31x	245	9	Type	Type	NNP
cord-332165-31tbc31x	245	10	11	11	CD
cord-332165-31tbc31x	245	11	Recombinant	Recombinant	NNP
cord-332165-31tbc31x	245	12	Virus	Virus	NNP
cord-332165-31tbc31x	245	13	-	-	HYPH
cord-332165-31tbc31x	245	14	like	like	JJ
cord-332165-31tbc31x	245	15	Particles	particle	NNS
cord-332165-31tbc31x	245	16	Interacts	interact	VBZ
cord-332165-31tbc31x	245	17	with	with	IN
cord-332165-31tbc31x	245	18	Heparin	Heparin	NNP
cord-332165-31tbc31x	245	19	and	and	CC
cord-332165-31tbc31x	245	20	Cell	cell	NN
cord-332165-31tbc31x	245	21	-	-	HYPH
cord-332165-31tbc31x	245	22	surface	surface	NN
cord-332165-31tbc31x	245	23	Glycosaminoglycans	Glycosaminoglycans	NNPS
cord-332165-31tbc31x	245	24	on	on	IN
cord-332165-31tbc31x	245	25	Human	Human	NNP
cord-332165-31tbc31x	245	26	Keratinocytes	Keratinocytes	NNPS
cord-332165-31tbc31x	245	27	Human	Human	NNP
cord-332165-31tbc31x	245	28	Papillomavirus	Papillomavirus	NNP
cord-332165-31tbc31x	245	29	Infection	infection	NN
cord-332165-31tbc31x	246	1	Requires	require	VBZ
cord-332165-31tbc31x	246	2	Cell	cell	NN
cord-332165-31tbc31x	246	3	Surface	surface	NN
cord-332165-31tbc31x	246	4	Heparan	Heparan	NNP
cord-332165-31tbc31x	246	5	Sulfate	Sulfate	NNP
cord-332165-31tbc31x	246	6	Human	Human	NNP
cord-332165-31tbc31x	246	7	Papillomavirus	Papillomavirus	NNP
cord-332165-31tbc31x	246	8	Types	Types	NNPS
cord-332165-31tbc31x	246	9	16	16	CD
cord-332165-31tbc31x	246	10	,	,	,
cord-332165-31tbc31x	246	11	18	18	CD
cord-332165-31tbc31x	246	12	,	,	,
cord-332165-31tbc31x	246	13	and	and	CC
cord-332165-31tbc31x	246	14	31	31	CD
cord-332165-31tbc31x	246	15	Share	share	NN
cord-332165-31tbc31x	246	16	Similar	Similar	NNP
cord-332165-31tbc31x	246	17	Endocytic	Endocytic	NNP
cord-332165-31tbc31x	246	18	Requirements	Requirements	NNPS
cord-332165-31tbc31x	246	19	for	for	IN
cord-332165-31tbc31x	246	20	Entry	entry	NN
cord-332165-31tbc31x	247	1	The	the	DT
cord-332165-31tbc31x	247	2	three	three	CD
cord-332165-31tbc31x	247	3	-	-	HYPH
cord-332165-31tbc31x	247	4	dimensional	dimensional	JJ
cord-332165-31tbc31x	247	5	structure	structure	NN
cord-332165-31tbc31x	247	6	of	of	IN
cord-332165-31tbc31x	247	7	reovirus	reovirus	NNP
cord-332165-31tbc31x	247	8	obtained	obtain	VBN
cord-332165-31tbc31x	247	9	by	by	IN
cord-332165-31tbc31x	247	10	cryo	cryo	NN
cord-332165-31tbc31x	247	11	-	-	HYPH
cord-332165-31tbc31x	247	12	electron	electron	NN
cord-332165-31tbc31x	247	13	microscopy	microscopy	NN
cord-332165-31tbc31x	247	14	Structure	structure	NN
cord-332165-31tbc31x	247	15	of	of	IN
cord-332165-31tbc31x	247	16	the	the	DT
cord-332165-31tbc31x	247	17	reovirus	reovirus	NNP
cord-332165-31tbc31x	247	18	core	core	NN
cord-332165-31tbc31x	247	19	at	at	IN
cord-332165-31tbc31x	247	20	3.6	3.6	CD
cord-332165-31tbc31x	247	21	?	?	.
cord-332165-31tbc31x	248	1	Å	å	NN
cord-332165-31tbc31x	248	2	resolution	resolution	NN
cord-332165-31tbc31x	248	3	X	x	NN
cord-332165-31tbc31x	248	4	-	-	NN
cord-332165-31tbc31x	248	5	ray	ray	NN
cord-332165-31tbc31x	248	6	crystal	crystal	NN
cord-332165-31tbc31x	248	7	structure	structure	NN
cord-332165-31tbc31x	248	8	of	of	IN
cord-332165-31tbc31x	248	9	the	the	DT
cord-332165-31tbc31x	248	10	rotavirus	rotavirus	JJ
cord-332165-31tbc31x	248	11	inner	inner	JJ
cord-332165-31tbc31x	248	12	capsid	capsid	NN
cord-332165-31tbc31x	248	13	particle	particle	NN
cord-332165-31tbc31x	248	14	at	at	IN
cord-332165-31tbc31x	248	15	3.8	3.8	CD
cord-332165-31tbc31x	248	16	a	a	DT
cord-332165-31tbc31x	248	17	resolution	resolution	NN
cord-332165-31tbc31x	248	18	Sigma	Sigma	NNP
cord-332165-31tbc31x	248	19	1	1	CD
cord-332165-31tbc31x	248	20	protein	protein	NN
cord-332165-31tbc31x	248	21	of	of	IN
cord-332165-31tbc31x	248	22	mammalian	mammalian	JJ
cord-332165-31tbc31x	248	23	reoviruses	reovirus	NNS
cord-332165-31tbc31x	248	24	extends	extend	VBZ
cord-332165-31tbc31x	248	25	from	from	IN
cord-332165-31tbc31x	248	26	the	the	DT
cord-332165-31tbc31x	248	27	surfaces	surface	NNS
cord-332165-31tbc31x	248	28	of	of	IN
cord-332165-31tbc31x	248	29	viral	viral	JJ
cord-332165-31tbc31x	248	30	particles	particle	NNS
cord-332165-31tbc31x	249	1	The	the	DT
cord-332165-31tbc31x	249	2	GM2	GM2	NNP
cord-332165-31tbc31x	249	3	Glycan	Glycan	NNP
cord-332165-31tbc31x	249	4	Serves	serve	VBZ
cord-332165-31tbc31x	249	5	as	as	IN
cord-332165-31tbc31x	249	6	a	a	DT
cord-332165-31tbc31x	249	7	Functional	Functional	NNP
cord-332165-31tbc31x	249	8	Coreceptor	Coreceptor	NNP
cord-332165-31tbc31x	249	9	for	for	IN
cord-332165-31tbc31x	249	10	Serotype	Serotype	NNP
cord-332165-31tbc31x	249	11	1	1	CD
cord-332165-31tbc31x	249	12	Reovirus	Reovirus	NNP
cord-332165-31tbc31x	249	13	Crystal	Crystal	NNP
cord-332165-31tbc31x	249	14	structure	structure	NN
cord-332165-31tbc31x	249	15	of	of	IN
cord-332165-31tbc31x	249	16	reovirus	reovirus	NNP
cord-332165-31tbc31x	249	17	attachment	attachment	NNP
cord-332165-31tbc31x	249	18	protein	protein	NNP
cord-332165-31tbc31x	249	19	sigma1	sigma1	NN
cord-332165-31tbc31x	249	20	in	in	IN
cord-332165-31tbc31x	249	21	complex	complex	NN
cord-332165-31tbc31x	249	22	with	with	IN
cord-332165-31tbc31x	249	23	sialylated	sialylated	JJ
cord-332165-31tbc31x	249	24	oligosaccharides	oligosaccharide	NNS
cord-332165-31tbc31x	249	25	Three	three	CD
cord-332165-31tbc31x	249	26	-	-	HYPH
cord-332165-31tbc31x	249	27	dimensional	dimensional	JJ
cord-332165-31tbc31x	249	28	visualization	visualization	NN
cord-332165-31tbc31x	249	29	of	of	IN
cord-332165-31tbc31x	249	30	the	the	DT
cord-332165-31tbc31x	249	31	rotavirus	rotavirus	JJ
cord-332165-31tbc31x	249	32	hemagglutinin	hemagglutinin	NN
cord-332165-31tbc31x	249	33	structure	structure	NN
cord-332165-31tbc31x	249	34	Comparison	Comparison	NNP
cord-332165-31tbc31x	249	35	of	of	IN
cord-332165-31tbc31x	249	36	human	human	JJ
cord-332165-31tbc31x	249	37	,	,	,
cord-332165-31tbc31x	249	38	simian	simian	JJ
cord-332165-31tbc31x	249	39	,	,	,
cord-332165-31tbc31x	249	40	and	and	CC
cord-332165-31tbc31x	249	41	bovine	bovine	JJ
cord-332165-31tbc31x	249	42	rotaviruses	rotavirus	NNS
cord-332165-31tbc31x	249	43	for	for	IN
cord-332165-31tbc31x	249	44	requirement	requirement	NN
cord-332165-31tbc31x	249	45	of	of	IN
cord-332165-31tbc31x	249	46	sialic	sialic	JJ
cord-332165-31tbc31x	249	47	acid	acid	NN
cord-332165-31tbc31x	249	48	in	in	IN
cord-332165-31tbc31x	249	49	hemagglutination	hemagglutination	NN
cord-332165-31tbc31x	249	50	and	and	CC
cord-332165-31tbc31x	249	51	cell	cell	NN
cord-332165-31tbc31x	249	52	adsorption	adsorption	NN
cord-332165-31tbc31x	249	53	Role	role	NN
cord-332165-31tbc31x	249	54	of	of	IN
cord-332165-31tbc31x	249	55	sialic	sialic	JJ
cord-332165-31tbc31x	249	56	acids	acid	NNS
cord-332165-31tbc31x	249	57	in	in	IN
cord-332165-31tbc31x	249	58	rotavirus	rotavirus	JJ
cord-332165-31tbc31x	249	59	infection	infection	NN
cord-332165-31tbc31x	249	60	Sialic	Sialic	NNP
cord-332165-31tbc31x	249	61	acid	acid	JJ
cord-332165-31tbc31x	249	62	dependence	dependence	NN
cord-332165-31tbc31x	249	63	in	in	IN
cord-332165-31tbc31x	249	64	rotavirus	rotavirus	JJ
cord-332165-31tbc31x	249	65	host	host	NN
cord-332165-31tbc31x	249	66	cell	cell	NN
cord-332165-31tbc31x	249	67	invasion	invasion	NN
cord-332165-31tbc31x	250	1	The	the	DT
cord-332165-31tbc31x	250	2	rhesus	rhesu	NNS
cord-332165-31tbc31x	250	3	rotavirus	rotavirus	VBP
cord-332165-31tbc31x	250	4	VP4	vp4	JJ
cord-332165-31tbc31x	250	5	sialic	sialic	NN
cord-332165-31tbc31x	250	6	acid	acid	NN
cord-332165-31tbc31x	250	7	binding	bind	VBG
cord-332165-31tbc31x	250	8	domain	domain	NN
cord-332165-31tbc31x	250	9	has	have	VBZ
cord-332165-31tbc31x	250	10	a	a	DT
cord-332165-31tbc31x	250	11	galectin	galectin	XX
cord-332165-31tbc31x	250	12	fold	fold	VB
cord-332165-31tbc31x	250	13	with	with	IN
cord-332165-31tbc31x	250	14	a	a	DT
cord-332165-31tbc31x	250	15	novel	novel	JJ
cord-332165-31tbc31x	250	16	carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	250	17	binding	bind	VBG
cord-332165-31tbc31x	250	18	site	site	NN
cord-332165-31tbc31x	250	19	Atomic	Atomic	NNP
cord-332165-31tbc31x	250	20	model	model	NN
cord-332165-31tbc31x	250	21	of	of	IN
cord-332165-31tbc31x	250	22	an	an	DT
cord-332165-31tbc31x	250	23	infectious	infectious	JJ
cord-332165-31tbc31x	250	24	rotavirus	rotavirus	NN
cord-332165-31tbc31x	250	25	particle	particle	NN
cord-332165-31tbc31x	251	1	The	the	DT
cord-332165-31tbc31x	251	2	structure	structure	NN
cord-332165-31tbc31x	251	3	of	of	IN
cord-332165-31tbc31x	251	4	the	the	DT
cord-332165-31tbc31x	251	5	adenovirus	adenovirus	NN
cord-332165-31tbc31x	251	6	capsid	capsid	NN
cord-332165-31tbc31x	251	7	Image	image	NN
cord-332165-31tbc31x	251	8	reconstruction	reconstruction	NN
cord-332165-31tbc31x	251	9	reveals	reveal	VBZ
cord-332165-31tbc31x	251	10	the	the	DT
cord-332165-31tbc31x	251	11	complex	complex	JJ
cord-332165-31tbc31x	251	12	molecular	molecular	JJ
cord-332165-31tbc31x	251	13	organization	organization	NN
cord-332165-31tbc31x	251	14	of	of	IN
cord-332165-31tbc31x	251	15	adenovirus	adenovirus	NN
cord-332165-31tbc31x	251	16	Crystal	Crystal	NNP
cord-332165-31tbc31x	251	17	Structure	Structure	NNP
cord-332165-31tbc31x	251	18	of	of	IN
cord-332165-31tbc31x	251	19	Species	Species	NNP
cord-332165-31tbc31x	251	20	D	D	NNP
cord-332165-31tbc31x	251	21	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	251	22	Fiber	Fiber	NNP
cord-332165-31tbc31x	251	23	Knobs	Knobs	NNPS
cord-332165-31tbc31x	251	24	and	and	CC
cord-332165-31tbc31x	251	25	Their	-PRON-	PRP$
cord-332165-31tbc31x	251	26	Sialic	Sialic	NNP
cord-332165-31tbc31x	251	27	Acid	acid	NN
cord-332165-31tbc31x	251	28	Binding	Binding	NNP
cord-332165-31tbc31x	251	29	Sites	Sites	NNPS
cord-332165-31tbc31x	251	30	Structural	structural	JJ
cord-332165-31tbc31x	251	31	basis	basis	NN
cord-332165-31tbc31x	251	32	of	of	IN
cord-332165-31tbc31x	251	33	preexisting	preexist	VBG
cord-332165-31tbc31x	251	34	immunity	immunity	NN
cord-332165-31tbc31x	251	35	to	to	IN
cord-332165-31tbc31x	251	36	the	the	DT
cord-332165-31tbc31x	251	37	2009	2009	CD
cord-332165-31tbc31x	251	38	H1N1	H1N1	NNP
cord-332165-31tbc31x	251	39	pandemic	pandemic	NN
cord-332165-31tbc31x	251	40	influenza	influenza	NN
cord-332165-31tbc31x	251	41	virus	virus	NN
cord-332165-31tbc31x	251	42	Functional	functional	JJ
cord-332165-31tbc31x	251	43	significance	significance	NN
cord-332165-31tbc31x	251	44	of	of	IN
cord-332165-31tbc31x	251	45	sialidase	sialidase	NN
cord-332165-31tbc31x	251	46	during	during	IN
cord-332165-31tbc31x	251	47	influenza	influenza	NN
cord-332165-31tbc31x	251	48	virus	virus	NN
cord-332165-31tbc31x	251	49	multiplication	multiplication	NN
cord-332165-31tbc31x	251	50	Functional	functional	JJ
cord-332165-31tbc31x	251	51	Significance	significance	NN
cord-332165-31tbc31x	251	52	of	of	IN
cord-332165-31tbc31x	251	53	Sialidase	Sialidase	NNP
cord-332165-31tbc31x	251	54	during	during	IN
cord-332165-31tbc31x	251	55	Influenza	Influenza	NNP
cord-332165-31tbc31x	251	56	Virus	Virus	NNP
cord-332165-31tbc31x	251	57	Multiplication	Multiplication	NNP
cord-332165-31tbc31x	251	58	:	:	:
cord-332165-31tbc31x	252	1	An	an	DT
cord-332165-31tbc31x	252	2	Electron	Electron	NNP
cord-332165-31tbc31x	252	3	Microscope	Microscope	NNP
cord-332165-31tbc31x	252	4	Study	Study	NNP
cord-332165-31tbc31x	252	5	Inhibition	inhibition	NN
cord-332165-31tbc31x	252	6	of	of	IN
cord-332165-31tbc31x	252	7	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	252	8	activity	activity	NN
cord-332165-31tbc31x	252	9	by	by	IN
cord-332165-31tbc31x	252	10	derivatives	derivative	NNS
cord-332165-31tbc31x	252	11	of	of	IN
cord-332165-31tbc31x	252	12	2-deoxy-2,3-dehydro	2-deoxy-2,3-dehydro	NNP
cord-332165-31tbc31x	252	13	-	-	HYPH
cord-332165-31tbc31x	252	14	N	n	CD
cord-332165-31tbc31x	252	15	-	-	HYPH
cord-332165-31tbc31x	252	16	acetylneuraminic	acetylneuraminic	NNP
cord-332165-31tbc31x	252	17	acid	acid	NN
cord-332165-31tbc31x	252	18	Inhibition	inhibition	NN
cord-332165-31tbc31x	252	19	of	of	IN
cord-332165-31tbc31x	252	20	influenza	influenza	NN
cord-332165-31tbc31x	252	21	and	and	CC
cord-332165-31tbc31x	252	22	parainfluenza	parainfluenza	NNP
cord-332165-31tbc31x	252	23	virus	virus	NN
cord-332165-31tbc31x	252	24	replication	replication	NN
cord-332165-31tbc31x	252	25	in	in	IN
cord-332165-31tbc31x	252	26	tissue	tissue	NN
cord-332165-31tbc31x	252	27	culture	culture	NN
cord-332165-31tbc31x	252	28	by	by	IN
cord-332165-31tbc31x	252	29	2-deoxy-2,3-dehydro	2-deoxy-2,3-dehydro	NNP
cord-332165-31tbc31x	252	30	-	-	HYPH
cord-332165-31tbc31x	252	31	N	n	CD
cord-332165-31tbc31x	252	32	-	-	HYPH
cord-332165-31tbc31x	252	33	trifluoroacetylneuraminic	trifluoroacetylneuraminic	NN
cord-332165-31tbc31x	252	34	acid	acid	NN
cord-332165-31tbc31x	252	35	(	(	-LRB-
cord-332165-31tbc31x	252	36	FANA	FANA	NNP
cord-332165-31tbc31x	252	37	)	)	-RRB-
cord-332165-31tbc31x	253	1	Rational	rational	JJ
cord-332165-31tbc31x	253	2	design	design	NN
cord-332165-31tbc31x	253	3	of	of	IN
cord-332165-31tbc31x	253	4	potent	potent	JJ
cord-332165-31tbc31x	253	5	sialidase	sialidase	NN
cord-332165-31tbc31x	253	6	-	-	HYPH
cord-332165-31tbc31x	253	7	based	base	VBN
cord-332165-31tbc31x	253	8	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	253	9	of	of	IN
cord-332165-31tbc31x	253	10	influenza	influenza	NN
cord-332165-31tbc31x	253	11	virus	virus	NN
cord-332165-31tbc31x	253	12	replication	replication	NN
cord-332165-31tbc31x	253	13	4-Guanidino-2,4-dideoxy-2,3-dehydro	4-guanidino-2,4-dideoxy-2,3-dehydro	CD
cord-332165-31tbc31x	253	14	-	-	HYPH
cord-332165-31tbc31x	253	15	N	n	CD
cord-332165-31tbc31x	253	16	-	-	HYPH
cord-332165-31tbc31x	253	17	acetylneuraminic	acetylneuraminic	NNP
cord-332165-31tbc31x	253	18	acid	acid	NN
cord-332165-31tbc31x	253	19	is	be	VBZ
cord-332165-31tbc31x	253	20	a	a	DT
cord-332165-31tbc31x	253	21	highly	highly	RB
cord-332165-31tbc31x	253	22	effective	effective	JJ
cord-332165-31tbc31x	253	23	inhibitor	inhibitor	NN
cord-332165-31tbc31x	253	24	both	both	DT
cord-332165-31tbc31x	253	25	of	of	IN
cord-332165-31tbc31x	253	26	the	the	DT
cord-332165-31tbc31x	253	27	sialidase	sialidase	NN
cord-332165-31tbc31x	253	28	(	(	-LRB-
cord-332165-31tbc31x	253	29	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	253	30	)	)	-RRB-
cord-332165-31tbc31x	253	31	and	and	CC
cord-332165-31tbc31x	253	32	of	of	IN
cord-332165-31tbc31x	253	33	growth	growth	NN
cord-332165-31tbc31x	253	34	of	of	IN
cord-332165-31tbc31x	253	35	a	a	DT
cord-332165-31tbc31x	253	36	wide	wide	JJ
cord-332165-31tbc31x	253	37	range	range	NN
cord-332165-31tbc31x	253	38	of	of	IN
cord-332165-31tbc31x	253	39	influenza	influenza	NN
cord-332165-31tbc31x	253	40	A	a	NN
cord-332165-31tbc31x	253	41	and	and	CC
cord-332165-31tbc31x	253	42	B	b	NN
cord-332165-31tbc31x	253	43	viruses	virus	NNS
cord-332165-31tbc31x	253	44	in	in	IN
cord-332165-31tbc31x	253	45	vitro	vitro	FW
cord-332165-31tbc31x	253	46	Structure	structure	NN
cord-332165-31tbc31x	253	47	-	-	HYPH
cord-332165-31tbc31x	253	48	Based	Based	NNP
cord-332165-31tbc31x	253	49	Inhibitors	Inhibitors	NNP
cord-332165-31tbc31x	253	50	of	of	IN
cord-332165-31tbc31x	253	51	Influenza	Influenza	NNP
cord-332165-31tbc31x	253	52	Virus	Virus	NNP
cord-332165-31tbc31x	253	53	Sialidase	Sialidase	NNP
cord-332165-31tbc31x	253	54	.	.	.
cord-332165-31tbc31x	254	1	A	a	DT
cord-332165-31tbc31x	254	2	Benzoic	Benzoic	NNP
cord-332165-31tbc31x	254	3	Acid	acid	NN
cord-332165-31tbc31x	254	4	Lead	lead	NN
cord-332165-31tbc31x	254	5	with	with	IN
cord-332165-31tbc31x	254	6	Novel	Novel	NNP
cord-332165-31tbc31x	254	7	Interaction	Interaction	NNP
cord-332165-31tbc31x	254	8	Synthesis	Synthesis	NNP
cord-332165-31tbc31x	254	9	and	and	CC
cord-332165-31tbc31x	254	10	influenza	influenza	NN
cord-332165-31tbc31x	254	11	neuraminidase	neuraminidase	NN
cord-332165-31tbc31x	254	12	inhibitory	inhibitory	JJ
cord-332165-31tbc31x	254	13	activity	activity	NN
cord-332165-31tbc31x	254	14	of	of	IN
cord-332165-31tbc31x	254	15	aromatic	aromatic	JJ
cord-332165-31tbc31x	254	16	analogs	analog	NNS
cord-332165-31tbc31x	254	17	of	of	IN
cord-332165-31tbc31x	254	18	sialic	sialic	NN
cord-332165-31tbc31x	254	19	-	-	HYPH
cord-332165-31tbc31x	254	20	acid	acid	NN
cord-332165-31tbc31x	254	21	Influenza	Influenza	NNP
cord-332165-31tbc31x	254	22	Neuraminidase	Neuraminidase	NNP
cord-332165-31tbc31x	254	23	Inhibitors	Inhibitors	NNP
cord-332165-31tbc31x	254	24	Possessing	possess	VBG
cord-332165-31tbc31x	254	25	a	a	DT
cord-332165-31tbc31x	254	26	Novel	Novel	NNP
cord-332165-31tbc31x	254	27	Hydrophobic	Hydrophobic	NNP
cord-332165-31tbc31x	254	28	Interaction	Interaction	NNP
cord-332165-31tbc31x	254	29	in	in	IN
cord-332165-31tbc31x	254	30	the	the	DT
cord-332165-31tbc31x	254	31	Enzyme	Enzyme	NNP
cord-332165-31tbc31x	254	32	Active	Active	NNP
cord-332165-31tbc31x	254	33	Site	Site	NNP
cord-332165-31tbc31x	254	34	:	:	:
cord-332165-31tbc31x	254	35	Design	Design	NNP
cord-332165-31tbc31x	254	36	,	,	,
cord-332165-31tbc31x	254	37	Synthesis	Synthesis	NNP
cord-332165-31tbc31x	254	38	,	,	,
cord-332165-31tbc31x	254	39	and	and	CC
cord-332165-31tbc31x	254	40	Structural	Structural	NNP
cord-332165-31tbc31x	254	41	Analysis	Analysis	NNP
cord-332165-31tbc31x	254	42	of	of	IN
cord-332165-31tbc31x	254	43	Carbocyclic	Carbocyclic	NNP
cord-332165-31tbc31x	254	44	Sialic	Sialic	NNP
cord-332165-31tbc31x	254	45	Acid	acid	NN
cord-332165-31tbc31x	254	46	Analogues	analogue	NNS
cord-332165-31tbc31x	254	47	with	with	IN
cord-332165-31tbc31x	254	48	Potent	Potent	NNP
cord-332165-31tbc31x	254	49	Anti	Anti	NNP
cord-332165-31tbc31x	254	50	-	-	JJ
cord-332165-31tbc31x	254	51	Influenza	influenza	JJ
cord-332165-31tbc31x	254	52	Activity	Activity	NNP
cord-332165-31tbc31x	254	53	Synthesis	Synthesis	NNP
cord-332165-31tbc31x	254	54	of	of	IN
cord-332165-31tbc31x	254	55	a	a	DT
cord-332165-31tbc31x	254	56	carbocyclic	carbocyclic	JJ
cord-332165-31tbc31x	254	57	sialic	sialic	NN
cord-332165-31tbc31x	254	58	acid	acid	NN
cord-332165-31tbc31x	254	59	analogue	analogue	NN
cord-332165-31tbc31x	254	60	for	for	IN
cord-332165-31tbc31x	254	61	the	the	DT
cord-332165-31tbc31x	254	62	inhibition	inhibition	NN
cord-332165-31tbc31x	254	63	of	of	IN
cord-332165-31tbc31x	254	64	influenza	influenza	NN
cord-332165-31tbc31x	254	65	virus	virus	NN
cord-332165-31tbc31x	254	66	neuraminidase	neuraminidase	FW
cord-332165-31tbc31x	254	67	Evidence	evidence	NN
cord-332165-31tbc31x	254	68	for	for	IN
cord-332165-31tbc31x	254	69	a	a	DT
cord-332165-31tbc31x	254	70	sialosyl	sialosyl	NNP
cord-332165-31tbc31x	254	71	cation	cation	NN
cord-332165-31tbc31x	254	72	transition	transition	NN
cord-332165-31tbc31x	254	73	-	-	HYPH
cord-332165-31tbc31x	254	74	state	state	NN
cord-332165-31tbc31x	254	75	complex	complex	NN
cord-332165-31tbc31x	254	76	in	in	IN
cord-332165-31tbc31x	254	77	the	the	DT
cord-332165-31tbc31x	254	78	reaction	reaction	NN
cord-332165-31tbc31x	254	79	of	of	IN
cord-332165-31tbc31x	254	80	sialidase	sialidase	NN
cord-332165-31tbc31x	254	81	from	from	IN
cord-332165-31tbc31x	254	82	influenza	influenza	NN
cord-332165-31tbc31x	254	83	virus	virus	NN
cord-332165-31tbc31x	255	1	A	a	DT
cord-332165-31tbc31x	255	2	study	study	NN
cord-332165-31tbc31x	255	3	of	of	IN
cord-332165-31tbc31x	255	4	the	the	DT
cord-332165-31tbc31x	255	5	active	active	JJ
cord-332165-31tbc31x	255	6	site	site	NN
cord-332165-31tbc31x	255	7	of	of	IN
cord-332165-31tbc31x	255	8	influenza	influenza	NNP
cord-332165-31tbc31x	255	9	virus	virus	NN
cord-332165-31tbc31x	255	10	sialidase	sialidase	NN
cord-332165-31tbc31x	255	11	:	:	:
cord-332165-31tbc31x	255	12	An	an	DT
cord-332165-31tbc31x	255	13	approach	approach	NN
cord-332165-31tbc31x	255	14	to	to	IN
cord-332165-31tbc31x	255	15	the	the	DT
cord-332165-31tbc31x	255	16	rational	rational	JJ
cord-332165-31tbc31x	255	17	design	design	NN
cord-332165-31tbc31x	255	18	of	of	IN
cord-332165-31tbc31x	255	19	novel	novel	JJ
cord-332165-31tbc31x	255	20	anti	anti	JJ
cord-332165-31tbc31x	255	21	-	-	JJ
cord-332165-31tbc31x	255	22	influenza	influenza	JJ
cord-332165-31tbc31x	255	23	drugs	drug	NNS
cord-332165-31tbc31x	255	24	Polyacrylamides	polyacrylamide	NNS
cord-332165-31tbc31x	255	25	bearing	bear	VBG
cord-332165-31tbc31x	255	26	pendant	pendant	NN
cord-332165-31tbc31x	255	27	α	α	NN
cord-332165-31tbc31x	255	28	-	-	HYPH
cord-332165-31tbc31x	255	29	sialoside	sialoside	NN
cord-332165-31tbc31x	255	30	groups	group	NNS
cord-332165-31tbc31x	255	31	strongly	strongly	RB
cord-332165-31tbc31x	255	32	inhibit	inhibit	VBP
cord-332165-31tbc31x	255	33	agglutination	agglutination	NN
cord-332165-31tbc31x	255	34	of	of	IN
cord-332165-31tbc31x	255	35	erythrocytes	erythrocyte	NNS
cord-332165-31tbc31x	255	36	by	by	IN
cord-332165-31tbc31x	255	37	influenza	influenza	NN
cord-332165-31tbc31x	255	38	-	-	HYPH
cord-332165-31tbc31x	255	39	virus	virus	NN
cord-332165-31tbc31x	255	40	Effective	effective	JJ
cord-332165-31tbc31x	255	41	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	255	42	of	of	IN
cord-332165-31tbc31x	255	43	hemagglutination	hemagglutination	NN
cord-332165-31tbc31x	255	44	by	by	IN
cord-332165-31tbc31x	255	45	influenza	influenza	NN
cord-332165-31tbc31x	255	46	virus	virus	NN
cord-332165-31tbc31x	255	47	synthesized	synthesize	VBN
cord-332165-31tbc31x	255	48	from	from	IN
cord-332165-31tbc31x	255	49	polymers	polymer	NNS
cord-332165-31tbc31x	255	50	having	have	VBG
cord-332165-31tbc31x	255	51	active	active	JJ
cord-332165-31tbc31x	255	52	ester	ester	NN
cord-332165-31tbc31x	255	53	groups	group	NNS
cord-332165-31tbc31x	255	54	.	.	.
cord-332165-31tbc31x	256	1	Insight	insight	NN
cord-332165-31tbc31x	256	2	into	into	IN
cord-332165-31tbc31x	256	3	mechanism	mechanism	NN
cord-332165-31tbc31x	256	4	of	of	IN
cord-332165-31tbc31x	256	5	inhibition	inhibition	NN
cord-332165-31tbc31x	256	6	Generation	generation	NN
cord-332165-31tbc31x	256	7	and	and	CC
cord-332165-31tbc31x	256	8	in	in	IN
cord-332165-31tbc31x	256	9	situ	situ	JJ
cord-332165-31tbc31x	256	10	evaluation	evaluation	NN
cord-332165-31tbc31x	256	11	of	of	IN
cord-332165-31tbc31x	256	12	libraries	library	NNS
cord-332165-31tbc31x	256	13	of	of	IN
cord-332165-31tbc31x	256	14	poly(acrylic	poly(acrylic	JJ
cord-332165-31tbc31x	256	15	acid	acid	NN
cord-332165-31tbc31x	256	16	)	)	-RRB-
cord-332165-31tbc31x	256	17	presenting	present	VBG
cord-332165-31tbc31x	256	18	sialosides	sialoside	NNS
cord-332165-31tbc31x	256	19	as	as	IN
cord-332165-31tbc31x	256	20	side	side	NN
cord-332165-31tbc31x	256	21	chains	chain	NNS
cord-332165-31tbc31x	256	22	as	as	IN
cord-332165-31tbc31x	256	23	polyvalent	polyvalent	JJ
cord-332165-31tbc31x	256	24	inhibitors	inhibitor	NNS
cord-332165-31tbc31x	256	25	of	of	IN
cord-332165-31tbc31x	256	26	influenza	influenza	NN
cord-332165-31tbc31x	256	27	-	-	HYPH
cord-332165-31tbc31x	256	28	mediated	mediate	VBN
cord-332165-31tbc31x	256	29	hemagglutination	hemagglutination	NN
cord-332165-31tbc31x	256	30	Inhibition	inhibition	NN
cord-332165-31tbc31x	256	31	of	of	IN
cord-332165-31tbc31x	256	32	Viral	Viral	NNP
cord-332165-31tbc31x	256	33	Adhesion	Adhesion	NNP
cord-332165-31tbc31x	256	34	and	and	CC
cord-332165-31tbc31x	256	35	Infection	Infection	NNP
cord-332165-31tbc31x	256	36	by	by	IN
cord-332165-31tbc31x	256	37	Sialic	Sialic	NNP
cord-332165-31tbc31x	256	38	-	-	HYPH
cord-332165-31tbc31x	256	39	Acid	acid	NN
cord-332165-31tbc31x	256	40	-	-	HYPH
cord-332165-31tbc31x	256	41	Conjugated	conjugate	VBN
cord-332165-31tbc31x	256	42	Dendritic	Dendritic	NNP
cord-332165-31tbc31x	256	43	Polymers	Polymers	NNP
cord-332165-31tbc31x	256	44	Polymeric	Polymeric	NNP
cord-332165-31tbc31x	256	45	inhibitor	inhibitor	NN
cord-332165-31tbc31x	256	46	of	of	IN
cord-332165-31tbc31x	256	47	influenza	influenza	NN
cord-332165-31tbc31x	256	48	virus	virus	NN
cord-332165-31tbc31x	256	49	attachment	attachment	NN
cord-332165-31tbc31x	256	50	protects	protect	VBZ
cord-332165-31tbc31x	256	51	mice	mouse	NNS
cord-332165-31tbc31x	256	52	from	from	IN
cord-332165-31tbc31x	256	53	experimental	experimental	JJ
cord-332165-31tbc31x	256	54	influenza	influenza	NN
cord-332165-31tbc31x	256	55	infection	infection	NN
cord-332165-31tbc31x	257	1	Linear	linear	JJ
cord-332165-31tbc31x	257	2	polysialoside	polysialoside	NN
cord-332165-31tbc31x	257	3	outperforms	outperform	VBZ
cord-332165-31tbc31x	257	4	dendritic	dendritic	JJ
cord-332165-31tbc31x	257	5	analogs	analog	NNS
cord-332165-31tbc31x	257	6	for	for	IN
cord-332165-31tbc31x	257	7	inhibition	inhibition	NN
cord-332165-31tbc31x	257	8	of	of	IN
cord-332165-31tbc31x	257	9	influenza	influenza	NN
cord-332165-31tbc31x	257	10	virus	virus	NN
cord-332165-31tbc31x	257	11	infection	infection	NN
cord-332165-31tbc31x	257	12	in	in	IN
cord-332165-31tbc31x	257	13	vitro	vitro	FW
cord-332165-31tbc31x	257	14	and	and	CC
cord-332165-31tbc31x	257	15	in	in	IN
cord-332165-31tbc31x	257	16	vivo	vivo	NNP
cord-332165-31tbc31x	257	17	Pathogen	Pathogen	NNP
cord-332165-31tbc31x	257	18	Inhibition	inhibition	NN
cord-332165-31tbc31x	257	19	by	by	IN
cord-332165-31tbc31x	257	20	Multivalent	Multivalent	NNP
cord-332165-31tbc31x	257	21	Ligand	Ligand	NNP
cord-332165-31tbc31x	257	22	Architectures	Architectures	NNPS
cord-332165-31tbc31x	257	23	Carbohydrate	carbohydrate	NN
cord-332165-31tbc31x	257	24	-	-	HYPH
cord-332165-31tbc31x	257	25	protein	protein	NN
cord-332165-31tbc31x	257	26	interactions	interaction	NNS
cord-332165-31tbc31x	257	27	and	and	CC
cord-332165-31tbc31x	257	28	multivalency	multivalency	NN
cord-332165-31tbc31x	257	29	:	:	:
cord-332165-31tbc31x	258	1	Implications	implication	NNS
cord-332165-31tbc31x	258	2	for	for	IN
cord-332165-31tbc31x	258	3	the	the	DT
cord-332165-31tbc31x	258	4	inhibition	inhibition	NN
cord-332165-31tbc31x	258	5	of	of	IN
cord-332165-31tbc31x	258	6	influenza	influenza	NN
cord-332165-31tbc31x	258	7	A	a	DT
cord-332165-31tbc31x	258	8	virus	virus	NN
cord-332165-31tbc31x	258	9	infections	infection	NNS
cord-332165-31tbc31x	258	10	Properties	property	NNS
cord-332165-31tbc31x	258	11	of	of	IN
cord-332165-31tbc31x	258	12	the	the	DT
cord-332165-31tbc31x	258	13	Glomerular	Glomerular	NNP
cord-332165-31tbc31x	258	14	Barrier	Barrier	NNP
cord-332165-31tbc31x	258	15	and	and	CC
cord-332165-31tbc31x	258	16	Mechanisms	Mechanisms	NNPS
cord-332165-31tbc31x	258	17	of	of	IN
cord-332165-31tbc31x	258	18	Proteinuria	Proteinuria	NNP
cord-332165-31tbc31x	258	19	Enhanced	Enhanced	NNP
cord-332165-31tbc31x	258	20	Inhibition	Inhibition	NNP
cord-332165-31tbc31x	258	21	of	of	IN
cord-332165-31tbc31x	258	22	Influenza	Influenza	NNP
cord-332165-31tbc31x	258	23	A	A	NNP
cord-332165-31tbc31x	258	24	Virus	virus	NN
cord-332165-31tbc31x	258	25	Adhesion	adhesion	NN
cord-332165-31tbc31x	258	26	by	by	IN
cord-332165-31tbc31x	258	27	Di	Di	NNP
cord-332165-31tbc31x	258	28	-	-	:
cord-332165-31tbc31x	258	29	and	and	CC
cord-332165-31tbc31x	258	30	Trivalent	Trivalent	NNP
cord-332165-31tbc31x	258	31	Hemagglutinin	Hemagglutinin	NNP
cord-332165-31tbc31x	258	32	Inhibitors	Inhibitors	NNP
cord-332165-31tbc31x	259	1	The	the	DT
cord-332165-31tbc31x	259	2	GD1a	GD1a	NNP
cord-332165-31tbc31x	259	3	glycan	glycan	NN
cord-332165-31tbc31x	259	4	is	be	VBZ
cord-332165-31tbc31x	259	5	a	a	DT
cord-332165-31tbc31x	259	6	cellular	cellular	JJ
cord-332165-31tbc31x	259	7	receptor	receptor	NN
cord-332165-31tbc31x	259	8	for	for	IN
cord-332165-31tbc31x	259	9	adenoviruses	adenovirus	NNS
cord-332165-31tbc31x	259	10	causing	cause	VBG
cord-332165-31tbc31x	259	11	epidemic	epidemic	NN
cord-332165-31tbc31x	259	12	keratoconjunctivitis	keratoconjunctivitis	NNP
cord-332165-31tbc31x	259	13	A	a	DT
cord-332165-31tbc31x	259	14	Potent	Potent	NNP
cord-332165-31tbc31x	259	15	Trivalent	Trivalent	NNP
cord-332165-31tbc31x	259	16	Sialic	Sialic	NNP
cord-332165-31tbc31x	259	17	Acid	Acid	NNP
cord-332165-31tbc31x	259	18	Inhibitor	Inhibitor	NNP
cord-332165-31tbc31x	259	19	of	of	IN
cord-332165-31tbc31x	259	20	Adenovirus	Adenovirus	NNP
cord-332165-31tbc31x	259	21	Type	Type	NNP
cord-332165-31tbc31x	259	22	37	37	CD
cord-332165-31tbc31x	259	23	Infection	infection	NN
cord-332165-31tbc31x	259	24	of	of	IN
cord-332165-31tbc31x	259	25	Human	Human	NNP
cord-332165-31tbc31x	259	26	Corneal	Corneal	NNP
cord-332165-31tbc31x	259	27	Cells	Cells	NNPS
cord-332165-31tbc31x	260	1	Divalent	Divalent	NNP
cord-332165-31tbc31x	261	1	Sialylated	Sialylated	NNP
cord-332165-31tbc31x	261	2	Precision	Precision	NNP
cord-332165-31tbc31x	261	3	Glycooligomers	Glycooligomers	NNPS
cord-332165-31tbc31x	261	4	Binding	Binding	NNP
cord-332165-31tbc31x	261	5	to	to	IN
cord-332165-31tbc31x	261	6	Polyomaviruses	Polyomaviruses	NNP
cord-332165-31tbc31x	261	7	and	and	CC
cord-332165-31tbc31x	261	8	the	the	DT
cord-332165-31tbc31x	261	9	Effect	Effect	NNP
cord-332165-31tbc31x	261	10	of	of	IN
cord-332165-31tbc31x	261	11	Different	different	JJ
cord-332165-31tbc31x	261	12	Linkers	linker	NNS
cord-332165-31tbc31x	262	1	This	this	DT
cord-332165-31tbc31x	262	2	article	article	NN
cord-332165-31tbc31x	262	3	is	be	VBZ
cord-332165-31tbc31x	262	4	an	an	DT
cord-332165-31tbc31x	262	5	open	open	JJ
cord-332165-31tbc31x	262	6	access	access	NN
cord-332165-31tbc31x	262	7	article	article	NN
cord-332165-31tbc31x	262	8	distributed	distribute	VBN
cord-332165-31tbc31x	262	9	under	under	IN
cord-332165-31tbc31x	262	10	the	the	DT
cord-332165-31tbc31x	262	11	terms	term	NNS
cord-332165-31tbc31x	262	12	and	and	CC
cord-332165-31tbc31x	262	13	conditions	condition	NNS
cord-332165-31tbc31x	262	14	of	of	IN
cord-332165-31tbc31x	262	15	the	the	DT
cord-332165-31tbc31x	262	16	Creative	Creative	NNP
cord-332165-31tbc31x	262	17	Commons	Commons	NNP
cord-332165-31tbc31x	262	18	Attribution	Attribution	NNP
cord-332165-31tbc31x	262	19	(	(	-LRB-
cord-332165-31tbc31x	262	20	CC	CC	NNP
cord-332165-31tbc31x	262	21	BY	by	IN
cord-332165-31tbc31x	262	22	)	)	-RRB-
cord-332165-31tbc31x	262	23	license	license	NN
cord-332165-31tbc31x	263	1	We	-PRON-	PRP
cord-332165-31tbc31x	263	2	thank	thank	VBP
cord-332165-31tbc31x	263	3	the	the	DT
cord-332165-31tbc31x	263	4	Swiss	Swiss	NNP
cord-332165-31tbc31x	263	5	Institute	Institute	NNP
cord-332165-31tbc31x	263	6	of	of	IN
cord-332165-31tbc31x	263	7	Bioinformatics	Bioinformatics	NNP
cord-332165-31tbc31x	263	8	for	for	IN
cord-332165-31tbc31x	263	9	the	the	DT
cord-332165-31tbc31x	263	10	provision	provision	NN
cord-332165-31tbc31x	263	11	of	of	IN
cord-332165-31tbc31x	263	12	the	the	DT
cord-332165-31tbc31x	263	13	ExPASy	ExPASy	NNP
cord-332165-31tbc31x	263	14	Viralzone	Viralzone	NNP
cord-332165-31tbc31x	263	15	and	and	CC
cord-332165-31tbc31x	263	16	the	the	DT
cord-332165-31tbc31x	263	17	SCRIPPS	SCRIPPS	NNP
cord-332165-31tbc31x	263	18	institute	institute	NN
cord-332165-31tbc31x	263	19	for	for	IN
cord-332165-31tbc31x	263	20	the	the	DT
cord-332165-31tbc31x	263	21	provision	provision	NN
cord-332165-31tbc31x	263	22	of	of	IN
cord-332165-31tbc31x	263	23	the	the	DT
cord-332165-31tbc31x	263	24	VIPER	VIPER	NNP
cord-332165-31tbc31x	263	25	data	datum	NNS
cord-332165-31tbc31x	263	26	bank	bank	NNP
cord-332165-31tbc31x	263	27	-	-	:
cord-332165-31tbc31x	263	28	two	two	CD
cord-332165-31tbc31x	263	29	very	very	RB
cord-332165-31tbc31x	263	30	helpful	helpful	JJ
cord-332165-31tbc31x	263	31	resources	resource	NNS
cord-332165-31tbc31x	263	32	of	of	IN
cord-332165-31tbc31x	263	33	virus	virus	NN
cord-332165-31tbc31x	263	34	knowledge	knowledge	NN
cord-332165-31tbc31x	263	35	.	.	.
cord-332165-31tbc31x	264	1	We	-PRON-	PRP
cord-332165-31tbc31x	264	2	apologize	apologize	VBP
cord-332165-31tbc31x	264	3	to	to	IN
cord-332165-31tbc31x	264	4	our	-PRON-	PRP$
cord-332165-31tbc31x	264	5	many	many	JJ
cord-332165-31tbc31x	264	6	colleagues	colleague	NNS
cord-332165-31tbc31x	264	7	whose	whose	WP$
cord-332165-31tbc31x	264	8	work	work	NN
cord-332165-31tbc31x	264	9	could	could	MD
cord-332165-31tbc31x	264	10	not	not	RB
cord-332165-31tbc31x	264	11	be	be	VB
cord-332165-31tbc31x	264	12	discussed	discuss	VBN
cord-332165-31tbc31x	264	13	and	and	CC
cord-332165-31tbc31x	264	14	cited	cite	VBN
cord-332165-31tbc31x	264	15	here	here	RB
cord-332165-31tbc31x	264	16	due	due	IN
cord-332165-31tbc31x	264	17	to	to	IN
cord-332165-31tbc31x	264	18	space	space	NN
cord-332165-31tbc31x	264	19	considerations	consideration	NNS
cord-332165-31tbc31x	264	20	.	.	.
cord-332165-31tbc31x	265	1	The	the	DT
cord-332165-31tbc31x	265	2	authors	author	NNS
cord-332165-31tbc31x	265	3	declare	declare	VBP
cord-332165-31tbc31x	265	4	no	no	DT
cord-332165-31tbc31x	265	5	conflict	conflict	NN
cord-332165-31tbc31x	265	6	of	of	IN
cord-332165-31tbc31x	265	7	interest	interest	NN
cord-332165-31tbc31x	265	8	.	.	.