id sid tid token lemma pos cord-302953-gr2kk9w4 1 1 key key JJ cord-302953-gr2kk9w4 1 2 : : : cord-302953-gr2kk9w4 1 3 cord-302953-gr2kk9w4 cord-302953-gr2kk9w4 JJ cord-302953-gr2kk9w4 1 4 authors author NNS cord-302953-gr2kk9w4 1 5 : : : cord-302953-gr2kk9w4 1 6 Baxter Baxter NNP cord-302953-gr2kk9w4 1 7 , , , cord-302953-gr2kk9w4 1 8 Victoria Victoria NNP cord-302953-gr2kk9w4 1 9 K. K. NNP cord-302953-gr2kk9w4 1 10 ; ; : cord-302953-gr2kk9w4 1 11 Griffin Griffin NNP cord-302953-gr2kk9w4 1 12 , , , cord-302953-gr2kk9w4 1 13 Diane Diane NNP cord-302953-gr2kk9w4 1 14 E. E. NNP cord-302953-gr2kk9w4 1 15 title title NN cord-302953-gr2kk9w4 1 16 : : : cord-302953-gr2kk9w4 1 17 Interferon Interferon NNP cord-302953-gr2kk9w4 1 18 - - HYPH cord-302953-gr2kk9w4 1 19 Gamma Gamma NNP cord-302953-gr2kk9w4 1 20 Modulation Modulation NNP cord-302953-gr2kk9w4 1 21 of of IN cord-302953-gr2kk9w4 1 22 the the DT cord-302953-gr2kk9w4 1 23 Local Local NNP cord-302953-gr2kk9w4 1 24 T T NNP cord-302953-gr2kk9w4 1 25 Cell Cell NNP cord-302953-gr2kk9w4 1 26 Response response NN cord-302953-gr2kk9w4 1 27 to to IN cord-302953-gr2kk9w4 1 28 Alphavirus Alphavirus NNP cord-302953-gr2kk9w4 1 29 Encephalomyelitis Encephalomyelitis NNP cord-302953-gr2kk9w4 1 30 date date NN cord-302953-gr2kk9w4 1 31 : : : cord-302953-gr2kk9w4 1 32 2020 2020 CD cord-302953-gr2kk9w4 1 33 - - HYPH cord-302953-gr2kk9w4 1 34 01 01 CD cord-302953-gr2kk9w4 1 35 - - HYPH cord-302953-gr2kk9w4 1 36 16 16 CD cord-302953-gr2kk9w4 1 37 journal journal NN cord-302953-gr2kk9w4 1 38 : : : cord-302953-gr2kk9w4 2 1 Viruses virus NNS cord-302953-gr2kk9w4 2 2 DOI DOI NNP cord-302953-gr2kk9w4 2 3 : : : cord-302953-gr2kk9w4 3 1 10.3390 10.3390 CD cord-302953-gr2kk9w4 3 2 / / SYM cord-302953-gr2kk9w4 3 3 v12010113 v12010113 NNP cord-302953-gr2kk9w4 3 4 sha sha NNP cord-302953-gr2kk9w4 3 5 : : : cord-302953-gr2kk9w4 3 6 f51b986600acc015fa48820a1ec11c90ea871d6d f51b986600acc015fa48820a1ec11c90ea871d6d NNS cord-302953-gr2kk9w4 3 7 doc_id doc_id CD cord-302953-gr2kk9w4 3 8 : : : cord-302953-gr2kk9w4 3 9 302953 302953 CD cord-302953-gr2kk9w4 3 10 cord_uid cord_uid NNS cord-302953-gr2kk9w4 3 11 : : : cord-302953-gr2kk9w4 4 1 gr2kk9w4 gr2kk9w4 NNP cord-302953-gr2kk9w4 4 2 Infection infection NN cord-302953-gr2kk9w4 4 3 of of IN cord-302953-gr2kk9w4 4 4 mice mouse NNS cord-302953-gr2kk9w4 4 5 with with IN cord-302953-gr2kk9w4 4 6 Sindbis Sindbis NNP cord-302953-gr2kk9w4 4 7 virus virus NN cord-302953-gr2kk9w4 4 8 ( ( -LRB- cord-302953-gr2kk9w4 4 9 SINV SINV NNP cord-302953-gr2kk9w4 4 10 ) ) -RRB- cord-302953-gr2kk9w4 4 11 provides provide VBZ cord-302953-gr2kk9w4 4 12 a a DT cord-302953-gr2kk9w4 4 13 model model NN cord-302953-gr2kk9w4 4 14 for for IN cord-302953-gr2kk9w4 4 15 examining examine VBG cord-302953-gr2kk9w4 4 16 the the DT cord-302953-gr2kk9w4 4 17 role role NN cord-302953-gr2kk9w4 4 18 of of IN cord-302953-gr2kk9w4 4 19 the the DT cord-302953-gr2kk9w4 4 20 immune immune JJ cord-302953-gr2kk9w4 4 21 response response NN cord-302953-gr2kk9w4 4 22 to to IN cord-302953-gr2kk9w4 4 23 alphavirus alphavirus NNP cord-302953-gr2kk9w4 4 24 infection infection NN cord-302953-gr2kk9w4 4 25 of of IN cord-302953-gr2kk9w4 4 26 the the DT cord-302953-gr2kk9w4 4 27 central central JJ cord-302953-gr2kk9w4 4 28 nervous nervous JJ cord-302953-gr2kk9w4 4 29 system system NN cord-302953-gr2kk9w4 4 30 ( ( -LRB- cord-302953-gr2kk9w4 4 31 CNS CNS NNP cord-302953-gr2kk9w4 4 32 ) ) -RRB- cord-302953-gr2kk9w4 4 33 . . . cord-302953-gr2kk9w4 5 1 Interferon interferon NN cord-302953-gr2kk9w4 5 2 - - HYPH cord-302953-gr2kk9w4 5 3 gamma gamma NN cord-302953-gr2kk9w4 5 4 ( ( -LRB- cord-302953-gr2kk9w4 5 5 IFN IFN NNP cord-302953-gr2kk9w4 5 6 - - HYPH cord-302953-gr2kk9w4 5 7 γ γ NNP cord-302953-gr2kk9w4 5 8 ) ) -RRB- cord-302953-gr2kk9w4 5 9 is be VBZ cord-302953-gr2kk9w4 5 10 an an DT cord-302953-gr2kk9w4 5 11 important important JJ cord-302953-gr2kk9w4 5 12 component component NN cord-302953-gr2kk9w4 5 13 of of IN cord-302953-gr2kk9w4 5 14 this this DT cord-302953-gr2kk9w4 5 15 response response NN cord-302953-gr2kk9w4 5 16 , , , cord-302953-gr2kk9w4 5 17 and and CC cord-302953-gr2kk9w4 5 18 we -PRON- PRP cord-302953-gr2kk9w4 5 19 show show VBP cord-302953-gr2kk9w4 5 20 that that IN cord-302953-gr2kk9w4 5 21 SINV SINV NNP cord-302953-gr2kk9w4 5 22 - - HYPH cord-302953-gr2kk9w4 5 23 infected infect VBN cord-302953-gr2kk9w4 5 24 differentiated differentiated JJ cord-302953-gr2kk9w4 5 25 neurons neuron NNS cord-302953-gr2kk9w4 5 26 respond respond VBP cord-302953-gr2kk9w4 5 27 to to IN cord-302953-gr2kk9w4 5 28 IFN IFN NNP cord-302953-gr2kk9w4 5 29 - - HYPH cord-302953-gr2kk9w4 5 30 γ γ NNP cord-302953-gr2kk9w4 5 31 in in IN cord-302953-gr2kk9w4 5 32 vitro vitro FW cord-302953-gr2kk9w4 5 33 by by IN cord-302953-gr2kk9w4 5 34 induction induction NN cord-302953-gr2kk9w4 5 35 of of IN cord-302953-gr2kk9w4 5 36 antiviral antiviral JJ cord-302953-gr2kk9w4 5 37 genes gene NNS cord-302953-gr2kk9w4 5 38 and and CC cord-302953-gr2kk9w4 5 39 suppression suppression NN cord-302953-gr2kk9w4 5 40 of of IN cord-302953-gr2kk9w4 5 41 virus virus NN cord-302953-gr2kk9w4 5 42 replication replication NN cord-302953-gr2kk9w4 5 43 . . . cord-302953-gr2kk9w4 6 1 To to TO cord-302953-gr2kk9w4 6 2 determine determine VB cord-302953-gr2kk9w4 6 3 the the DT cord-302953-gr2kk9w4 6 4 in in IN cord-302953-gr2kk9w4 6 5 vivo vivo NN cord-302953-gr2kk9w4 6 6 effects effect NNS cord-302953-gr2kk9w4 6 7 of of IN cord-302953-gr2kk9w4 6 8 IFN IFN NNP cord-302953-gr2kk9w4 6 9 - - HYPH cord-302953-gr2kk9w4 6 10 γ γ NN cord-302953-gr2kk9w4 6 11 on on IN cord-302953-gr2kk9w4 6 12 SINV SINV NNP cord-302953-gr2kk9w4 6 13 clearance clearance NN cord-302953-gr2kk9w4 6 14 and and CC cord-302953-gr2kk9w4 6 15 T t NN cord-302953-gr2kk9w4 6 16 cell cell NN cord-302953-gr2kk9w4 6 17 responses response NNS cord-302953-gr2kk9w4 6 18 , , , cord-302953-gr2kk9w4 6 19 C57BL/6 C57BL/6 NNP cord-302953-gr2kk9w4 6 20 mice mouse NNS cord-302953-gr2kk9w4 6 21 lacking lack VBG cord-302953-gr2kk9w4 6 22 IFN IFN NNP cord-302953-gr2kk9w4 6 23 - - HYPH cord-302953-gr2kk9w4 6 24 γ γ NNP cord-302953-gr2kk9w4 6 25 or or CC cord-302953-gr2kk9w4 6 26 IFN IFN NNP cord-302953-gr2kk9w4 6 27 - - HYPH cord-302953-gr2kk9w4 6 28 γ γ NN cord-302953-gr2kk9w4 6 29 receptor-1 receptor-1 NNS cord-302953-gr2kk9w4 6 30 were be VBD cord-302953-gr2kk9w4 6 31 compared compare VBN cord-302953-gr2kk9w4 6 32 to to IN cord-302953-gr2kk9w4 6 33 wild wild JJ cord-302953-gr2kk9w4 6 34 - - HYPH cord-302953-gr2kk9w4 6 35 type type NN cord-302953-gr2kk9w4 6 36 ( ( -LRB- cord-302953-gr2kk9w4 6 37 WT WT NNP cord-302953-gr2kk9w4 6 38 ) ) -RRB- cord-302953-gr2kk9w4 6 39 mice mouse NNS cord-302953-gr2kk9w4 6 40 after after IN cord-302953-gr2kk9w4 6 41 intracranial intracranial JJ cord-302953-gr2kk9w4 6 42 SINV SINV NNP cord-302953-gr2kk9w4 6 43 infection infection NN cord-302953-gr2kk9w4 6 44 . . . cord-302953-gr2kk9w4 7 1 In in IN cord-302953-gr2kk9w4 7 2 WT WT NNP cord-302953-gr2kk9w4 7 3 mice mouse NNS cord-302953-gr2kk9w4 7 4 , , , cord-302953-gr2kk9w4 7 5 IFN IFN NNP cord-302953-gr2kk9w4 7 6 - - HYPH cord-302953-gr2kk9w4 7 7 γ γ NNP cord-302953-gr2kk9w4 7 8 was be VBD cord-302953-gr2kk9w4 7 9 first first RB cord-302953-gr2kk9w4 7 10 produced produce VBN cord-302953-gr2kk9w4 7 11 in in IN cord-302953-gr2kk9w4 7 12 the the DT cord-302953-gr2kk9w4 7 13 CNS CNS NNP cord-302953-gr2kk9w4 7 14 by by IN cord-302953-gr2kk9w4 7 15 natural natural JJ cord-302953-gr2kk9w4 7 16 killer killer NN cord-302953-gr2kk9w4 7 17 cells cell NNS cord-302953-gr2kk9w4 7 18 and and CC cord-302953-gr2kk9w4 7 19 then then RB cord-302953-gr2kk9w4 7 20 by by IN cord-302953-gr2kk9w4 7 21 CD4(+ CD4(+ NNS cord-302953-gr2kk9w4 7 22 ) ) -RRB- cord-302953-gr2kk9w4 7 23 and and CC cord-302953-gr2kk9w4 7 24 CD8(+ cd8(+ CD cord-302953-gr2kk9w4 7 25 ) ) -RRB- cord-302953-gr2kk9w4 7 26 T t NN cord-302953-gr2kk9w4 7 27 cells cell NNS cord-302953-gr2kk9w4 7 28 . . . cord-302953-gr2kk9w4 8 1 Mice mouse NNS cord-302953-gr2kk9w4 8 2 with with IN cord-302953-gr2kk9w4 8 3 impaired impaired JJ cord-302953-gr2kk9w4 8 4 IFN IFN NNP cord-302953-gr2kk9w4 8 5 - - HYPH cord-302953-gr2kk9w4 8 6 γ γ NNP cord-302953-gr2kk9w4 8 7 signaling signal VBG cord-302953-gr2kk9w4 8 8 initiated initiate VBN cord-302953-gr2kk9w4 8 9 clearance clearance NN cord-302953-gr2kk9w4 8 10 of of IN cord-302953-gr2kk9w4 8 11 viral viral JJ cord-302953-gr2kk9w4 8 12 RNA RNA NNP cord-302953-gr2kk9w4 8 13 earlier early RBR cord-302953-gr2kk9w4 8 14 than than IN cord-302953-gr2kk9w4 8 15 WT WT NNP cord-302953-gr2kk9w4 8 16 mice mouse NNS cord-302953-gr2kk9w4 8 17 associated associate VBN cord-302953-gr2kk9w4 8 18 with with IN cord-302953-gr2kk9w4 8 19 CNS CNS NNP cord-302953-gr2kk9w4 8 20 entry entry NN cord-302953-gr2kk9w4 8 21 of of IN cord-302953-gr2kk9w4 8 22 more more JJR cord-302953-gr2kk9w4 8 23 granzyme granzyme NNS cord-302953-gr2kk9w4 8 24 B b NN cord-302953-gr2kk9w4 8 25 - - HYPH cord-302953-gr2kk9w4 8 26 producing produce VBG cord-302953-gr2kk9w4 8 27 CD8(+ CD8(+ NNS cord-302953-gr2kk9w4 8 28 ) ) -RRB- cord-302953-gr2kk9w4 8 29 T t NN cord-302953-gr2kk9w4 8 30 cells cell NNS cord-302953-gr2kk9w4 8 31 . . . cord-302953-gr2kk9w4 9 1 However however RB cord-302953-gr2kk9w4 9 2 , , , cord-302953-gr2kk9w4 9 3 these these DT cord-302953-gr2kk9w4 9 4 mice mouse NNS cord-302953-gr2kk9w4 9 5 established establish VBD cord-302953-gr2kk9w4 9 6 fewer few JJR cord-302953-gr2kk9w4 9 7 CD8(+ cd8(+ CD cord-302953-gr2kk9w4 9 8 ) ) -RRB- cord-302953-gr2kk9w4 9 9 tissue tissue NN cord-302953-gr2kk9w4 9 10 - - HYPH cord-302953-gr2kk9w4 9 11 resident resident NN cord-302953-gr2kk9w4 9 12 memory memory NN cord-302953-gr2kk9w4 9 13 T t NN cord-302953-gr2kk9w4 9 14 ( ( -LRB- cord-302953-gr2kk9w4 9 15 T(RM T(RM NNP cord-302953-gr2kk9w4 9 16 ) ) -RRB- cord-302953-gr2kk9w4 9 17 ) ) -RRB- cord-302953-gr2kk9w4 9 18 cells cell NNS cord-302953-gr2kk9w4 9 19 and and CC cord-302953-gr2kk9w4 9 20 were be VBD cord-302953-gr2kk9w4 9 21 more more RBR cord-302953-gr2kk9w4 9 22 likely likely JJ cord-302953-gr2kk9w4 9 23 to to TO cord-302953-gr2kk9w4 9 24 experience experience VB cord-302953-gr2kk9w4 9 25 reactivation reactivation NN cord-302953-gr2kk9w4 9 26 of of IN cord-302953-gr2kk9w4 9 27 viral viral JJ cord-302953-gr2kk9w4 9 28 RNA RNA NNP cord-302953-gr2kk9w4 9 29 synthesis synthesis NN cord-302953-gr2kk9w4 9 30 late late RB cord-302953-gr2kk9w4 9 31 after after IN cord-302953-gr2kk9w4 9 32 infection infection NN cord-302953-gr2kk9w4 9 33 . . . cord-302953-gr2kk9w4 10 1 Therefore therefore RB cord-302953-gr2kk9w4 10 2 , , , cord-302953-gr2kk9w4 10 3 IFN IFN NNP cord-302953-gr2kk9w4 10 4 - - HYPH cord-302953-gr2kk9w4 10 5 γ γ NNP cord-302953-gr2kk9w4 10 6 suppresses suppress VBZ cord-302953-gr2kk9w4 10 7 the the DT cord-302953-gr2kk9w4 10 8 local local JJ cord-302953-gr2kk9w4 10 9 development development NN cord-302953-gr2kk9w4 10 10 of of IN cord-302953-gr2kk9w4 10 11 granzyme granzyme NNS cord-302953-gr2kk9w4 10 12 B B NNP cord-302953-gr2kk9w4 10 13 - - HYPH cord-302953-gr2kk9w4 10 14 expressing express VBG cord-302953-gr2kk9w4 10 15 CD8(+ CD8(+ NNS cord-302953-gr2kk9w4 10 16 ) ) -RRB- cord-302953-gr2kk9w4 10 17 T t NN cord-302953-gr2kk9w4 10 18 cells cell NNS cord-302953-gr2kk9w4 10 19 and and CC cord-302953-gr2kk9w4 10 20 slows slow VBZ cord-302953-gr2kk9w4 10 21 viral viral JJ cord-302953-gr2kk9w4 10 22 RNA RNA NNP cord-302953-gr2kk9w4 10 23 clearance clearance NN cord-302953-gr2kk9w4 10 24 but but CC cord-302953-gr2kk9w4 10 25 promotes promote VBZ cord-302953-gr2kk9w4 10 26 CD8(+ cd8(+ CD cord-302953-gr2kk9w4 10 27 ) ) -RRB- cord-302953-gr2kk9w4 10 28 T(RM t(rm CD cord-302953-gr2kk9w4 10 29 ) ) -RRB- cord-302953-gr2kk9w4 10 30 cell cell NN cord-302953-gr2kk9w4 10 31 establishment establishment NN cord-302953-gr2kk9w4 10 32 . . . cord-302953-gr2kk9w4 11 1 Response response NN cord-302953-gr2kk9w4 11 2 to to IN cord-302953-gr2kk9w4 11 3 viral viral JJ cord-302953-gr2kk9w4 11 4 infections infection NNS cord-302953-gr2kk9w4 11 5 of of IN cord-302953-gr2kk9w4 11 6 the the DT cord-302953-gr2kk9w4 11 7 central central JJ cord-302953-gr2kk9w4 11 8 nervous nervous JJ cord-302953-gr2kk9w4 11 9 system system NN cord-302953-gr2kk9w4 11 10 ( ( -LRB- cord-302953-gr2kk9w4 11 11 CNS CNS NNP cord-302953-gr2kk9w4 11 12 ) ) -RRB- cord-302953-gr2kk9w4 11 13 poses pose VBZ cord-302953-gr2kk9w4 11 14 a a DT cord-302953-gr2kk9w4 11 15 unique unique JJ cord-302953-gr2kk9w4 11 16 problem problem NN cord-302953-gr2kk9w4 11 17 for for IN cord-302953-gr2kk9w4 11 18 the the DT cord-302953-gr2kk9w4 11 19 immune immune JJ cord-302953-gr2kk9w4 11 20 system system NN cord-302953-gr2kk9w4 11 21 . . . cord-302953-gr2kk9w4 12 1 The the DT cord-302953-gr2kk9w4 12 2 restrictive restrictive JJ cord-302953-gr2kk9w4 12 3 nature nature NN cord-302953-gr2kk9w4 12 4 of of IN cord-302953-gr2kk9w4 12 5 the the DT cord-302953-gr2kk9w4 12 6 blood blood NN cord-302953-gr2kk9w4 12 7 - - HYPH cord-302953-gr2kk9w4 12 8 brain brain NN cord-302953-gr2kk9w4 12 9 barrier barrier NN cord-302953-gr2kk9w4 12 10 limits limit VBZ cord-302953-gr2kk9w4 12 11 the the DT cord-302953-gr2kk9w4 12 12 ability ability NN cord-302953-gr2kk9w4 12 13 of of IN cord-302953-gr2kk9w4 12 14 proteins protein NNS cord-302953-gr2kk9w4 12 15 and and CC cord-302953-gr2kk9w4 12 16 immune immune JJ cord-302953-gr2kk9w4 12 17 cells cell NNS cord-302953-gr2kk9w4 12 18 to to TO cord-302953-gr2kk9w4 12 19 enter enter VB cord-302953-gr2kk9w4 12 20 into into IN cord-302953-gr2kk9w4 12 21 the the DT cord-302953-gr2kk9w4 12 22 brain brain NN cord-302953-gr2kk9w4 12 23 and and CC cord-302953-gr2kk9w4 12 24 spinal spinal JJ cord-302953-gr2kk9w4 12 25 cord cord NN cord-302953-gr2kk9w4 12 26 in in IN cord-302953-gr2kk9w4 12 27 response response NN cord-302953-gr2kk9w4 12 28 to to IN cord-302953-gr2kk9w4 12 29 a a DT cord-302953-gr2kk9w4 12 30 virus virus NN cord-302953-gr2kk9w4 12 31 infection infection NN cord-302953-gr2kk9w4 12 32 [ [ -LRB- cord-302953-gr2kk9w4 12 33 1 1 CD cord-302953-gr2kk9w4 12 34 ] ] -RRB- cord-302953-gr2kk9w4 12 35 . . . cord-302953-gr2kk9w4 13 1 Resident resident JJ cord-302953-gr2kk9w4 13 2 cells cell NNS cord-302953-gr2kk9w4 13 3 of of IN cord-302953-gr2kk9w4 13 4 the the DT cord-302953-gr2kk9w4 13 5 CNS CNS NNP cord-302953-gr2kk9w4 13 6 , , , cord-302953-gr2kk9w4 13 7 particularly particularly RB cord-302953-gr2kk9w4 13 8 neurons neuron NNS cord-302953-gr2kk9w4 13 9 , , , cord-302953-gr2kk9w4 13 10 have have VBP cord-302953-gr2kk9w4 13 11 a a DT cord-302953-gr2kk9w4 13 12 limited limited JJ cord-302953-gr2kk9w4 13 13 capacity capacity NN cord-302953-gr2kk9w4 13 14 to to TO cord-302953-gr2kk9w4 13 15 express express VB cord-302953-gr2kk9w4 13 16 major major JJ cord-302953-gr2kk9w4 13 17 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 13 18 complex complex NN cord-302953-gr2kk9w4 13 19 ( ( -LRB- cord-302953-gr2kk9w4 13 20 MHC MHC NNP cord-302953-gr2kk9w4 13 21 ) ) -RRB- cord-302953-gr2kk9w4 13 22 molecules molecule NNS cord-302953-gr2kk9w4 13 23 [ [ -LRB- cord-302953-gr2kk9w4 13 24 2 2 CD cord-302953-gr2kk9w4 13 25 , , , cord-302953-gr2kk9w4 13 26 3 3 CD cord-302953-gr2kk9w4 13 27 ] ] -RRB- cord-302953-gr2kk9w4 13 28 . . . cord-302953-gr2kk9w4 14 1 Because because IN cord-302953-gr2kk9w4 14 2 neurons neuron NNS cord-302953-gr2kk9w4 14 3 are be VBP cord-302953-gr2kk9w4 14 4 a a DT cord-302953-gr2kk9w4 14 5 valuable valuable JJ cord-302953-gr2kk9w4 14 6 but but CC cord-302953-gr2kk9w4 14 7 finite finite JJ cord-302953-gr2kk9w4 14 8 and and CC cord-302953-gr2kk9w4 14 9 minimally minimally RB cord-302953-gr2kk9w4 14 10 renewable renewable JJ cord-302953-gr2kk9w4 14 11 cell cell NN cord-302953-gr2kk9w4 14 12 population population NN cord-302953-gr2kk9w4 14 13 , , , cord-302953-gr2kk9w4 14 14 preservation preservation NN cord-302953-gr2kk9w4 14 15 of of IN cord-302953-gr2kk9w4 14 16 neuronal neuronal JJ cord-302953-gr2kk9w4 14 17 function function NN cord-302953-gr2kk9w4 14 18 requires require VBZ cord-302953-gr2kk9w4 14 19 that that IN cord-302953-gr2kk9w4 14 20 infected infected JJ cord-302953-gr2kk9w4 14 21 neurons neuron NNS cord-302953-gr2kk9w4 14 22 be be VB cord-302953-gr2kk9w4 14 23 allowed allow VBN cord-302953-gr2kk9w4 14 24 to to TO cord-302953-gr2kk9w4 14 25 survive survive VB cord-302953-gr2kk9w4 14 26 , , , cord-302953-gr2kk9w4 14 27 necessitating necessitate VBG cord-302953-gr2kk9w4 14 28 noncytolytic noncytolytic JJ cord-302953-gr2kk9w4 14 29 immune immune JJ cord-302953-gr2kk9w4 14 30 mechanisms mechanism NNS cord-302953-gr2kk9w4 14 31 to to TO cord-302953-gr2kk9w4 14 32 control control VB cord-302953-gr2kk9w4 14 33 virus virus NN cord-302953-gr2kk9w4 14 34 infection infection NN cord-302953-gr2kk9w4 14 35 . . . cord-302953-gr2kk9w4 15 1 Sindbis sindbis NN cord-302953-gr2kk9w4 15 2 virus virus NN cord-302953-gr2kk9w4 15 3 ( ( -LRB- cord-302953-gr2kk9w4 15 4 SINV SINV NNP cord-302953-gr2kk9w4 15 5 ) ) -RRB- cord-302953-gr2kk9w4 15 6 is be VBZ cord-302953-gr2kk9w4 15 7 the the DT cord-302953-gr2kk9w4 15 8 prototypic prototypic NNP cord-302953-gr2kk9w4 15 9 member member NN cord-302953-gr2kk9w4 15 10 of of IN cord-302953-gr2kk9w4 15 11 the the DT cord-302953-gr2kk9w4 15 12 alphaviruses alphavirus NNS cord-302953-gr2kk9w4 15 13 , , , cord-302953-gr2kk9w4 15 14 a a DT cord-302953-gr2kk9w4 15 15 genus genus NN cord-302953-gr2kk9w4 15 16 of of IN cord-302953-gr2kk9w4 15 17 enveloped envelop VBN cord-302953-gr2kk9w4 15 18 , , , cord-302953-gr2kk9w4 15 19 positive positive JJ cord-302953-gr2kk9w4 15 20 - - HYPH cord-302953-gr2kk9w4 15 21 sense sense NN cord-302953-gr2kk9w4 15 22 , , , cord-302953-gr2kk9w4 15 23 single single RB cord-302953-gr2kk9w4 15 24 - - HYPH cord-302953-gr2kk9w4 15 25 stranded strand VBN cord-302953-gr2kk9w4 15 26 RNA RNA NNP cord-302953-gr2kk9w4 15 27 viruses virus NNS cord-302953-gr2kk9w4 15 28 belonging belong VBG cord-302953-gr2kk9w4 15 29 to to IN cord-302953-gr2kk9w4 15 30 the the DT cord-302953-gr2kk9w4 15 31 Togaviridae Togaviridae NNP cord-302953-gr2kk9w4 15 32 family family NN cord-302953-gr2kk9w4 15 33 [ [ -LRB- cord-302953-gr2kk9w4 15 34 4 4 CD cord-302953-gr2kk9w4 15 35 ] ] -RRB- cord-302953-gr2kk9w4 15 36 . . . cord-302953-gr2kk9w4 16 1 SINV SINV NNP cord-302953-gr2kk9w4 16 2 is be VBZ cord-302953-gr2kk9w4 16 3 neurotropic neurotropic NNP cord-302953-gr2kk9w4 16 4 in in IN cord-302953-gr2kk9w4 16 5 mice mouse NNS cord-302953-gr2kk9w4 16 6 , , , cord-302953-gr2kk9w4 16 7 and and CC cord-302953-gr2kk9w4 16 8 when when WRB cord-302953-gr2kk9w4 16 9 mice mouse NNS cord-302953-gr2kk9w4 16 10 are be VBP cord-302953-gr2kk9w4 16 11 infected infect VBN cord-302953-gr2kk9w4 16 12 with with IN cord-302953-gr2kk9w4 16 13 a a DT cord-302953-gr2kk9w4 16 14 strain strain NN cord-302953-gr2kk9w4 16 15 of of IN cord-302953-gr2kk9w4 16 16 SINV SINV NNP cord-302953-gr2kk9w4 16 17 that that WDT cord-302953-gr2kk9w4 16 18 does do VBZ cord-302953-gr2kk9w4 16 19 not not RB cord-302953-gr2kk9w4 16 20 cause cause VB cord-302953-gr2kk9w4 16 21 fatal fatal JJ cord-302953-gr2kk9w4 16 22 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 16 23 ( ( -LRB- cord-302953-gr2kk9w4 16 24 e.g. e.g. RB cord-302953-gr2kk9w4 16 25 , , , cord-302953-gr2kk9w4 16 26 TE TE NNP cord-302953-gr2kk9w4 16 27 ) ) -RRB- cord-302953-gr2kk9w4 16 28 , , , cord-302953-gr2kk9w4 16 29 clearance clearance NN cord-302953-gr2kk9w4 16 30 of of IN cord-302953-gr2kk9w4 16 31 infection infection NN cord-302953-gr2kk9w4 16 32 from from IN cord-302953-gr2kk9w4 16 33 the the DT cord-302953-gr2kk9w4 16 34 CNS CNS NNP cord-302953-gr2kk9w4 16 35 occurs occur VBZ cord-302953-gr2kk9w4 16 36 in in IN cord-302953-gr2kk9w4 16 37 three three CD cord-302953-gr2kk9w4 16 38 phases phase NNS cord-302953-gr2kk9w4 16 39 [ [ -LRB- cord-302953-gr2kk9w4 16 40 5 5 CD cord-302953-gr2kk9w4 16 41 ] ] -RRB- cord-302953-gr2kk9w4 16 42 . . . cord-302953-gr2kk9w4 17 1 In in IN cord-302953-gr2kk9w4 17 2 Phase phase NN cord-302953-gr2kk9w4 17 3 1 1 CD cord-302953-gr2kk9w4 17 4 , , , cord-302953-gr2kk9w4 17 5 during during IN cord-302953-gr2kk9w4 17 6 the the DT cord-302953-gr2kk9w4 17 7 first first JJ cord-302953-gr2kk9w4 17 8 7 7 CD cord-302953-gr2kk9w4 17 9 to to TO cord-302953-gr2kk9w4 17 10 8 8 CD cord-302953-gr2kk9w4 17 11 days day NNS cord-302953-gr2kk9w4 17 12 post post NN cord-302953-gr2kk9w4 17 13 infection infection NN cord-302953-gr2kk9w4 17 14 ( ( -LRB- cord-302953-gr2kk9w4 17 15 DPI DPI NNP cord-302953-gr2kk9w4 17 16 ) ) -RRB- cord-302953-gr2kk9w4 17 17 , , , cord-302953-gr2kk9w4 17 18 both both CC cord-302953-gr2kk9w4 17 19 infectious infectious JJ cord-302953-gr2kk9w4 17 20 virus virus NN cord-302953-gr2kk9w4 17 21 and and CC cord-302953-gr2kk9w4 17 22 viral viral JJ cord-302953-gr2kk9w4 17 23 RNA RNA NNP cord-302953-gr2kk9w4 17 24 increase increase NN cord-302953-gr2kk9w4 17 25 rapidly rapidly RB cord-302953-gr2kk9w4 17 26 , , , cord-302953-gr2kk9w4 17 27 followed follow VBN cord-302953-gr2kk9w4 17 28 by by IN cord-302953-gr2kk9w4 17 29 clearance clearance NN cord-302953-gr2kk9w4 17 30 of of IN cord-302953-gr2kk9w4 17 31 infectious infectious JJ cord-302953-gr2kk9w4 17 32 virus virus NN cord-302953-gr2kk9w4 17 33 that that WDT cord-302953-gr2kk9w4 17 34 occurs occur VBZ cord-302953-gr2kk9w4 17 35 primarily primarily RB cord-302953-gr2kk9w4 17 36 through through IN cord-302953-gr2kk9w4 17 37 cooperative cooperative JJ cord-302953-gr2kk9w4 17 38 effects effect NNS cord-302953-gr2kk9w4 17 39 of of IN cord-302953-gr2kk9w4 17 40 anti anti JJ cord-302953-gr2kk9w4 17 41 - - JJ cord-302953-gr2kk9w4 17 42 SINV sinv JJ cord-302953-gr2kk9w4 17 43 antibody antibody NN cord-302953-gr2kk9w4 17 44 and and CC cord-302953-gr2kk9w4 17 45 the the DT cord-302953-gr2kk9w4 17 46 cytokine cytokine NN cord-302953-gr2kk9w4 17 47 interferon interferon NN cord-302953-gr2kk9w4 17 48 - - HYPH cord-302953-gr2kk9w4 17 49 gamma gamma NN cord-302953-gr2kk9w4 17 50 ( ( -LRB- cord-302953-gr2kk9w4 17 51 IFN IFN NNP cord-302953-gr2kk9w4 17 52 - - HYPH cord-302953-gr2kk9w4 17 53 γ γ NNP cord-302953-gr2kk9w4 17 54 ) ) -RRB- cord-302953-gr2kk9w4 17 55 [ [ -LRB- cord-302953-gr2kk9w4 17 56 6 6 CD cord-302953-gr2kk9w4 17 57 ] ] -RRB- cord-302953-gr2kk9w4 17 58 [ [ -LRB- cord-302953-gr2kk9w4 17 59 7 7 CD cord-302953-gr2kk9w4 17 60 ] ] -RRB- cord-302953-gr2kk9w4 18 1 [ [ -LRB- cord-302953-gr2kk9w4 18 2 8 8 CD cord-302953-gr2kk9w4 18 3 ] ] -RRB- cord-302953-gr2kk9w4 18 4 [ [ -LRB- cord-302953-gr2kk9w4 18 5 9 9 CD cord-302953-gr2kk9w4 18 6 ] ] -RRB- cord-302953-gr2kk9w4 18 7 . . . cord-302953-gr2kk9w4 19 1 In in IN cord-302953-gr2kk9w4 19 2 Phase phase NN cord-302953-gr2kk9w4 19 3 2 2 CD cord-302953-gr2kk9w4 19 4 , , , cord-302953-gr2kk9w4 19 5 from from IN cord-302953-gr2kk9w4 19 6 approximately approximately RB cord-302953-gr2kk9w4 19 7 10 10 CD cord-302953-gr2kk9w4 19 8 to to TO cord-302953-gr2kk9w4 19 9 60 60 CD cord-302953-gr2kk9w4 19 10 days day NNS cord-302953-gr2kk9w4 19 11 , , , cord-302953-gr2kk9w4 19 12 infectious infectious JJ cord-302953-gr2kk9w4 19 13 Four four CD cord-302953-gr2kk9w4 19 14 to to TO cord-302953-gr2kk9w4 19 15 six six CD cord-302953-gr2kk9w4 19 16 week week NN cord-302953-gr2kk9w4 19 17 - - HYPH cord-302953-gr2kk9w4 19 18 old old JJ cord-302953-gr2kk9w4 19 19 male male JJ cord-302953-gr2kk9w4 19 20 and and CC cord-302953-gr2kk9w4 19 21 female female JJ cord-302953-gr2kk9w4 19 22 wild wild JJ cord-302953-gr2kk9w4 19 23 - - HYPH cord-302953-gr2kk9w4 19 24 type type NN cord-302953-gr2kk9w4 19 25 C57BL/6 C57BL/6 NNP cord-302953-gr2kk9w4 19 26 ( ( -LRB- cord-302953-gr2kk9w4 19 27 WT WT NNP cord-302953-gr2kk9w4 19 28 ) ) -RRB- cord-302953-gr2kk9w4 19 29 mice mouse NNS cord-302953-gr2kk9w4 19 30 , , , cord-302953-gr2kk9w4 19 31 mice mouse NNS cord-302953-gr2kk9w4 19 32 deficient deficient JJ cord-302953-gr2kk9w4 19 33 in in IN cord-302953-gr2kk9w4 19 34 IFN IFN NNP cord-302953-gr2kk9w4 19 35 - - HYPH cord-302953-gr2kk9w4 19 36 γ γ NN cord-302953-gr2kk9w4 19 37 receptor receptor NN cord-302953-gr2kk9w4 19 38 1 1 CD cord-302953-gr2kk9w4 20 1 ( ( -LRB- cord-302953-gr2kk9w4 20 2 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 21 1 −/− −/− NNP cord-302953-gr2kk9w4 21 2 , , , cord-302953-gr2kk9w4 21 3 strain strain VB cord-302953-gr2kk9w4 21 4 B6.129S7-Ifngr1 B6.129S7-Ifngr1 NNP cord-302953-gr2kk9w4 21 5 tm1Agt tm1Agt NNP cord-302953-gr2kk9w4 21 6 /J /j NN cord-302953-gr2kk9w4 21 7 , , , cord-302953-gr2kk9w4 21 8 Jackson Jackson NNP cord-302953-gr2kk9w4 21 9 Labs Labs NNP cord-302953-gr2kk9w4 21 10 ) ) -RRB- cord-302953-gr2kk9w4 21 11 , , , cord-302953-gr2kk9w4 21 12 and and CC cord-302953-gr2kk9w4 21 13 mice mouse NNS cord-302953-gr2kk9w4 21 14 deficient deficient JJ cord-302953-gr2kk9w4 21 15 in in IN cord-302953-gr2kk9w4 21 16 IFN IFN NNP cord-302953-gr2kk9w4 21 17 - - HYPH cord-302953-gr2kk9w4 21 18 γ γ NNP cord-302953-gr2kk9w4 21 19 ( ( -LRB- cord-302953-gr2kk9w4 21 20 Ifng Ifng NNP cord-302953-gr2kk9w4 21 21 −/− −/− NNP cord-302953-gr2kk9w4 21 22 , , , cord-302953-gr2kk9w4 21 23 strain strain VB cord-302953-gr2kk9w4 21 24 B6.129S7-Ifng B6.129S7-Ifng NNP cord-302953-gr2kk9w4 21 25 tm1Ts tm1ts XX cord-302953-gr2kk9w4 21 26 /J /j NN cord-302953-gr2kk9w4 21 27 , , , cord-302953-gr2kk9w4 21 28 Jackson Jackson NNP cord-302953-gr2kk9w4 21 29 Labs Labs NNP cord-302953-gr2kk9w4 21 30 ) ) -RRB- cord-302953-gr2kk9w4 21 31 were be VBD cord-302953-gr2kk9w4 21 32 intracranially intracranially RB cord-302953-gr2kk9w4 21 33 ( ( -LRB- cord-302953-gr2kk9w4 21 34 IC IC NNP cord-302953-gr2kk9w4 21 35 ) ) -RRB- cord-302953-gr2kk9w4 21 36 inoculated inoculate VBD cord-302953-gr2kk9w4 21 37 with with IN cord-302953-gr2kk9w4 21 38 10 10 CD cord-302953-gr2kk9w4 21 39 3 3 CD cord-302953-gr2kk9w4 21 40 plaque plaque NN cord-302953-gr2kk9w4 21 41 forming form VBG cord-302953-gr2kk9w4 21 42 units unit NNS cord-302953-gr2kk9w4 21 43 ( ( -LRB- cord-302953-gr2kk9w4 21 44 pfu pfu NN cord-302953-gr2kk9w4 21 45 ) ) -RRB- cord-302953-gr2kk9w4 21 46 of of IN cord-302953-gr2kk9w4 21 47 the the DT cord-302953-gr2kk9w4 21 48 TE TE NNP cord-302953-gr2kk9w4 21 49 strain strain NN cord-302953-gr2kk9w4 21 50 of of IN cord-302953-gr2kk9w4 21 51 SINV SINV NNP cord-302953-gr2kk9w4 21 52 diluted dilute VBN cord-302953-gr2kk9w4 21 53 in in IN cord-302953-gr2kk9w4 21 54 20 20 CD cord-302953-gr2kk9w4 21 55 µL µl XX cord-302953-gr2kk9w4 22 1 PBS PBS NNP cord-302953-gr2kk9w4 22 2 or or CC cord-302953-gr2kk9w4 22 3 20 20 CD cord-302953-gr2kk9w4 22 4 µL µl XX cord-302953-gr2kk9w4 23 1 PBS PBS NNP cord-302953-gr2kk9w4 23 2 vehicle vehicle NN cord-302953-gr2kk9w4 23 3 while while IN cord-302953-gr2kk9w4 23 4 under under IN cord-302953-gr2kk9w4 23 5 light light JJ cord-302953-gr2kk9w4 23 6 isoflurane isoflurane JJ cord-302953-gr2kk9w4 23 7 anesthesia anesthesia NNP cord-302953-gr2kk9w4 23 8 . . . cord-302953-gr2kk9w4 24 1 For for IN cord-302953-gr2kk9w4 24 2 fresh fresh JJ cord-302953-gr2kk9w4 24 3 tissue tissue NN cord-302953-gr2kk9w4 24 4 collection collection NN cord-302953-gr2kk9w4 24 5 , , , cord-302953-gr2kk9w4 24 6 mice mouse NNS cord-302953-gr2kk9w4 24 7 were be VBD cord-302953-gr2kk9w4 24 8 euthanized euthanize VBN cord-302953-gr2kk9w4 24 9 by by IN cord-302953-gr2kk9w4 24 10 an an DT cord-302953-gr2kk9w4 24 11 overdose overdose NN cord-302953-gr2kk9w4 24 12 of of IN cord-302953-gr2kk9w4 24 13 isoflurane isoflurane JJ cord-302953-gr2kk9w4 24 14 anesthesia anesthesia NN cord-302953-gr2kk9w4 24 15 , , , cord-302953-gr2kk9w4 24 16 perfused perfuse VBN cord-302953-gr2kk9w4 24 17 with with IN cord-302953-gr2kk9w4 24 18 ice ice NN cord-302953-gr2kk9w4 24 19 - - HYPH cord-302953-gr2kk9w4 24 20 cold cold JJ cord-302953-gr2kk9w4 24 21 PBS PBS NNP cord-302953-gr2kk9w4 24 22 , , , cord-302953-gr2kk9w4 24 23 and and CC cord-302953-gr2kk9w4 24 24 cervical cervical JJ cord-302953-gr2kk9w4 24 25 lymph lymph NN cord-302953-gr2kk9w4 24 26 nodes node NNS cord-302953-gr2kk9w4 24 27 ( ( -LRB- cord-302953-gr2kk9w4 24 28 CLNs cln NNS cord-302953-gr2kk9w4 24 29 ) ) -RRB- cord-302953-gr2kk9w4 24 30 , , , cord-302953-gr2kk9w4 24 31 brains brain NNS cord-302953-gr2kk9w4 24 32 , , , cord-302953-gr2kk9w4 24 33 and/or and/or CC cord-302953-gr2kk9w4 24 34 spinal spinal JJ cord-302953-gr2kk9w4 24 35 cords cord NNS cord-302953-gr2kk9w4 24 36 were be VBD cord-302953-gr2kk9w4 24 37 collected collect VBN cord-302953-gr2kk9w4 24 38 . . . cord-302953-gr2kk9w4 25 1 The the DT cord-302953-gr2kk9w4 25 2 Johns Johns NNP cord-302953-gr2kk9w4 25 3 Hopkins Hopkins NNP cord-302953-gr2kk9w4 25 4 University University NNP cord-302953-gr2kk9w4 25 5 Institutional Institutional NNP cord-302953-gr2kk9w4 25 6 Animal Animal NNP cord-302953-gr2kk9w4 25 7 Care Care NNP cord-302953-gr2kk9w4 25 8 and and CC cord-302953-gr2kk9w4 25 9 Use Use NNP cord-302953-gr2kk9w4 25 10 Committee Committee NNP cord-302953-gr2kk9w4 25 11 approved approve VBD cord-302953-gr2kk9w4 25 12 protocols protocol NNS cord-302953-gr2kk9w4 25 13 for for IN cord-302953-gr2kk9w4 25 14 all all DT cord-302953-gr2kk9w4 25 15 studies study NNS cord-302953-gr2kk9w4 25 16 performed perform VBN cord-302953-gr2kk9w4 25 17 ( ( -LRB- cord-302953-gr2kk9w4 25 18 MO15H160 mo15h160 CD cord-302953-gr2kk9w4 25 19 approved approve VBD cord-302953-gr2kk9w4 25 20 06/14/2015 06/14/2015 CD cord-302953-gr2kk9w4 25 21 ; ; : cord-302953-gr2kk9w4 25 22 MO18H178 mo18h178 CD cord-302953-gr2kk9w4 25 23 approved approve VBD cord-302953-gr2kk9w4 25 24 06/13/2018 06/13/2018 CD cord-302953-gr2kk9w4 25 25 ) ) -RRB- cord-302953-gr2kk9w4 25 26 . . . cord-302953-gr2kk9w4 26 1 For for IN cord-302953-gr2kk9w4 26 2 preparation preparation NN cord-302953-gr2kk9w4 26 3 of of IN cord-302953-gr2kk9w4 26 4 lysates lysate NNS cord-302953-gr2kk9w4 26 5 , , , cord-302953-gr2kk9w4 26 6 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 26 7 cells cell NNS cord-302953-gr2kk9w4 26 8 pooled pool VBN cord-302953-gr2kk9w4 26 9 from from IN cord-302953-gr2kk9w4 26 10 three three CD cord-302953-gr2kk9w4 26 11 wells well NNS cord-302953-gr2kk9w4 26 12 were be VBD cord-302953-gr2kk9w4 26 13 incubated incubate VBN cord-302953-gr2kk9w4 26 14 on on IN cord-302953-gr2kk9w4 26 15 ice ice NN cord-302953-gr2kk9w4 26 16 for for IN cord-302953-gr2kk9w4 26 17 30 30 CD cord-302953-gr2kk9w4 26 18 min min NN cord-302953-gr2kk9w4 26 19 in in IN cord-302953-gr2kk9w4 26 20 RIPA RIPA NNP cord-302953-gr2kk9w4 26 21 buffer buffer NN cord-302953-gr2kk9w4 26 22 ( ( -LRB- cord-302953-gr2kk9w4 26 23 50 50 CD cord-302953-gr2kk9w4 26 24 mM mm CD cord-302953-gr2kk9w4 26 25 Tris Tris NNP cord-302953-gr2kk9w4 26 26 , , , cord-302953-gr2kk9w4 26 27 150 150 CD cord-302953-gr2kk9w4 26 28 mM mm CD cord-302953-gr2kk9w4 26 29 NaCl nacl NN cord-302953-gr2kk9w4 26 30 , , , cord-302953-gr2kk9w4 26 31 1 1 CD cord-302953-gr2kk9w4 26 32 % % NN cord-302953-gr2kk9w4 26 33 SDS SDS NNP cord-302953-gr2kk9w4 26 34 , , , cord-302953-gr2kk9w4 26 35 1 1 CD cord-302953-gr2kk9w4 26 36 % % NN cord-302953-gr2kk9w4 26 37 NP-40 NP-40 NNP cord-302953-gr2kk9w4 26 38 , , , cord-302953-gr2kk9w4 26 39 0.5 0.5 CD cord-302953-gr2kk9w4 26 40 % % NN cord-302953-gr2kk9w4 26 41 Na Na NNP cord-302953-gr2kk9w4 26 42 - - HYPH cord-302953-gr2kk9w4 26 43 deoxycholate deoxycholate NNP cord-302953-gr2kk9w4 26 44 , , , cord-302953-gr2kk9w4 26 45 1 1 CD cord-302953-gr2kk9w4 26 46 mM mm CD cord-302953-gr2kk9w4 26 47 EDTA EDTA NNP cord-302953-gr2kk9w4 26 48 ) ) -RRB- cord-302953-gr2kk9w4 26 49 and and CC cord-302953-gr2kk9w4 26 50 centrifuged centrifuge VBD cord-302953-gr2kk9w4 26 51 at at IN cord-302953-gr2kk9w4 26 52 12,000 12,000 CD cord-302953-gr2kk9w4 26 53 rpm rpm NN cord-302953-gr2kk9w4 26 54 for for IN cord-302953-gr2kk9w4 26 55 15 15 CD cord-302953-gr2kk9w4 26 56 min min NN cord-302953-gr2kk9w4 26 57 . . . cord-302953-gr2kk9w4 27 1 Total total JJ cord-302953-gr2kk9w4 27 2 protein protein NN cord-302953-gr2kk9w4 27 3 was be VBD cord-302953-gr2kk9w4 27 4 quantified quantify VBN cord-302953-gr2kk9w4 27 5 by by IN cord-302953-gr2kk9w4 27 6 DC DC NNP cord-302953-gr2kk9w4 27 7 Protein Protein NNP cord-302953-gr2kk9w4 27 8 assay assay NN cord-302953-gr2kk9w4 27 9 ( ( -LRB- cord-302953-gr2kk9w4 27 10 Bio Bio NNP cord-302953-gr2kk9w4 27 11 - - HYPH cord-302953-gr2kk9w4 27 12 Rad Rad NNP cord-302953-gr2kk9w4 27 13 , , , cord-302953-gr2kk9w4 27 14 Hercules Hercules NNP cord-302953-gr2kk9w4 27 15 , , , cord-302953-gr2kk9w4 27 16 CA CA NNP cord-302953-gr2kk9w4 27 17 , , , cord-302953-gr2kk9w4 27 18 USA USA NNP cord-302953-gr2kk9w4 27 19 ) ) -RRB- cord-302953-gr2kk9w4 27 20 using use VBG cord-302953-gr2kk9w4 27 21 a a DT cord-302953-gr2kk9w4 27 22 BSA BSA NNP cord-302953-gr2kk9w4 27 23 standard standard JJ cord-302953-gr2kk9w4 27 24 curve curve NN cord-302953-gr2kk9w4 27 25 , , , cord-302953-gr2kk9w4 27 26 and and CC cord-302953-gr2kk9w4 27 27 10 10 CD cord-302953-gr2kk9w4 27 28 µg µg NN cord-302953-gr2kk9w4 27 29 was be VBD cord-302953-gr2kk9w4 27 30 boiled boil VBN cord-302953-gr2kk9w4 27 31 in in IN cord-302953-gr2kk9w4 27 32 6X 6x CD cord-302953-gr2kk9w4 27 33 SDS SDS NNP cord-302953-gr2kk9w4 27 34 loading loading NN cord-302953-gr2kk9w4 27 35 buffer buffer NN cord-302953-gr2kk9w4 27 36 ( ( -LRB- cord-302953-gr2kk9w4 27 37 0.5 0.5 CD cord-302953-gr2kk9w4 27 38 M M NNP cord-302953-gr2kk9w4 27 39 Tris Tris NNP cord-302953-gr2kk9w4 27 40 ( ( -LRB- cord-302953-gr2kk9w4 27 41 pH pH NNP cord-302953-gr2kk9w4 27 42 6.8 6.8 CD cord-302953-gr2kk9w4 27 43 ) ) -RRB- cord-302953-gr2kk9w4 27 44 , , , cord-302953-gr2kk9w4 27 45 30 30 CD cord-302953-gr2kk9w4 27 46 % % NN cord-302953-gr2kk9w4 27 47 glycerol glycerol NN cord-302953-gr2kk9w4 27 48 , , . cord-302953-gr2kk9w4 28 1 10 10 CD cord-302953-gr2kk9w4 28 2 % % NN cord-302953-gr2kk9w4 28 3 SDS SDS NNP cord-302953-gr2kk9w4 28 4 , , , cord-302953-gr2kk9w4 28 5 0.12 0.12 CD cord-302953-gr2kk9w4 28 6 % % NN cord-302953-gr2kk9w4 28 7 bromophenol bromophenol NNP cord-302953-gr2kk9w4 28 8 blue blue NNP cord-302953-gr2kk9w4 28 9 , , , cord-302953-gr2kk9w4 28 10 6 6 CD cord-302953-gr2kk9w4 28 11 % % NN cord-302953-gr2kk9w4 28 12 β β NN cord-302953-gr2kk9w4 28 13 - - HYPH cord-302953-gr2kk9w4 28 14 mercaptoethanol mercaptoethanol NNP cord-302953-gr2kk9w4 28 15 ) ) -RRB- cord-302953-gr2kk9w4 28 16 for for IN cord-302953-gr2kk9w4 28 17 5 5 CD cord-302953-gr2kk9w4 28 18 min min NN cord-302953-gr2kk9w4 28 19 . . . cord-302953-gr2kk9w4 29 1 Samples sample NNS cord-302953-gr2kk9w4 29 2 were be VBD cord-302953-gr2kk9w4 29 3 run run VBN cord-302953-gr2kk9w4 29 4 on on IN cord-302953-gr2kk9w4 29 5 a a DT cord-302953-gr2kk9w4 29 6 10 10 CD cord-302953-gr2kk9w4 29 7 % % NN cord-302953-gr2kk9w4 29 8 SDS sds NN cord-302953-gr2kk9w4 29 9 - - HYPH cord-302953-gr2kk9w4 29 10 polyacrylamide polyacrylamide NN cord-302953-gr2kk9w4 29 11 gel gel NN cord-302953-gr2kk9w4 29 12 electrophoresis electrophoresis NN cord-302953-gr2kk9w4 29 13 ( ( -LRB- cord-302953-gr2kk9w4 29 14 PAGE page NN cord-302953-gr2kk9w4 29 15 ) ) -RRB- cord-302953-gr2kk9w4 29 16 gel gel NN cord-302953-gr2kk9w4 29 17 and and CC cord-302953-gr2kk9w4 29 18 transferred transfer VBN cord-302953-gr2kk9w4 29 19 to to IN cord-302953-gr2kk9w4 29 20 a a DT cord-302953-gr2kk9w4 29 21 nitrocellulose nitrocellulose JJ cord-302953-gr2kk9w4 29 22 membrane membrane NN cord-302953-gr2kk9w4 29 23 ( ( -LRB- cord-302953-gr2kk9w4 29 24 Bio Bio NNP cord-302953-gr2kk9w4 29 25 - - HYPH cord-302953-gr2kk9w4 29 26 Rad Rad NNP cord-302953-gr2kk9w4 29 27 ) ) -RRB- cord-302953-gr2kk9w4 29 28 . . . cord-302953-gr2kk9w4 30 1 Membranes membrane NNS cord-302953-gr2kk9w4 30 2 were be VBD cord-302953-gr2kk9w4 30 3 blocked block VBN cord-302953-gr2kk9w4 30 4 in in IN cord-302953-gr2kk9w4 30 5 TBS-0.1 tbs-0.1 CD cord-302953-gr2kk9w4 30 6 % % NN cord-302953-gr2kk9w4 30 7 Tween-20 Tween-20 NNP cord-302953-gr2kk9w4 30 8 ( ( -LRB- cord-302953-gr2kk9w4 30 9 TBST TBST NNP cord-302953-gr2kk9w4 30 10 ) ) -RRB- cord-302953-gr2kk9w4 30 11 + + SYM cord-302953-gr2kk9w4 30 12 5 5 CD cord-302953-gr2kk9w4 30 13 % % NN cord-302953-gr2kk9w4 30 14 milk milk NN cord-302953-gr2kk9w4 30 15 for for IN cord-302953-gr2kk9w4 30 16 1 1 CD cord-302953-gr2kk9w4 30 17 h h NN cord-302953-gr2kk9w4 30 18 at at IN cord-302953-gr2kk9w4 30 19 room room NN cord-302953-gr2kk9w4 30 20 temperature temperature NN cord-302953-gr2kk9w4 30 21 on on IN cord-302953-gr2kk9w4 30 22 a a DT cord-302953-gr2kk9w4 30 23 rocker rocker NN cord-302953-gr2kk9w4 30 24 and and CC cord-302953-gr2kk9w4 30 25 incubated incubate VBN cord-302953-gr2kk9w4 30 26 overnight overnight RB cord-302953-gr2kk9w4 30 27 at at IN cord-302953-gr2kk9w4 31 1 4 4 LS cord-302953-gr2kk9w4 31 2 • • NNS cord-302953-gr2kk9w4 32 1 C C NNP cord-302953-gr2kk9w4 32 2 on on IN cord-302953-gr2kk9w4 32 3 a a DT cord-302953-gr2kk9w4 32 4 rocker rocker NN cord-302953-gr2kk9w4 32 5 with with IN cord-302953-gr2kk9w4 32 6 primary primary JJ cord-302953-gr2kk9w4 32 7 antibody antibody NN cord-302953-gr2kk9w4 32 8 diluted dilute VBN cord-302953-gr2kk9w4 32 9 in in IN cord-302953-gr2kk9w4 32 10 TBST TBST NNP cord-302953-gr2kk9w4 32 11 + + CC cord-302953-gr2kk9w4 33 1 5 5 CD cord-302953-gr2kk9w4 33 2 % % NN cord-302953-gr2kk9w4 33 3 BSA BSA NNP cord-302953-gr2kk9w4 33 4 ( ( -LRB- cord-302953-gr2kk9w4 33 5 1:2000 1:2000 CD cord-302953-gr2kk9w4 33 6 rabbit rabbit NN cord-302953-gr2kk9w4 33 7 polyclonal polyclonal JJ cord-302953-gr2kk9w4 33 8 anti anti NNS cord-302953-gr2kk9w4 33 9 - - NNS cord-302953-gr2kk9w4 33 10 nsp3 nsp3 NNS cord-302953-gr2kk9w4 33 11 ; ; : cord-302953-gr2kk9w4 33 12 1:10,000 1:10,000 CD cord-302953-gr2kk9w4 33 13 rabbit rabbit NN cord-302953-gr2kk9w4 33 14 polyclonal polyclonal JJ cord-302953-gr2kk9w4 33 15 NSV NSV NNP cord-302953-gr2kk9w4 33 16 anti anti NNP cord-302953-gr2kk9w4 33 17 - - JJ cord-302953-gr2kk9w4 33 18 sera sera JJ cord-302953-gr2kk9w4 33 19 ; ; : cord-302953-gr2kk9w4 33 20 1:10,000 1:10,000 CD cord-302953-gr2kk9w4 33 21 mouse mouse NN cord-302953-gr2kk9w4 33 22 monoclonal monoclonal JJ cord-302953-gr2kk9w4 33 23 anti anti NNP cord-302953-gr2kk9w4 33 24 - - JJ cord-302953-gr2kk9w4 33 25 β β JJ cord-302953-gr2kk9w4 33 26 - - HYPH cord-302953-gr2kk9w4 33 27 actin actin NN cord-302953-gr2kk9w4 33 28 , , , cord-302953-gr2kk9w4 33 29 ( ( -LRB- cord-302953-gr2kk9w4 33 30 Millipore Millipore NNP cord-302953-gr2kk9w4 33 31 , , , cord-302953-gr2kk9w4 33 32 Burlington Burlington NNP cord-302953-gr2kk9w4 33 33 , , , cord-302953-gr2kk9w4 33 34 MA MA NNP cord-302953-gr2kk9w4 33 35 , , , cord-302953-gr2kk9w4 33 36 USA USA NNP cord-302953-gr2kk9w4 33 37 ) ) -RRB- cord-302953-gr2kk9w4 33 38 [ [ -LRB- cord-302953-gr2kk9w4 33 39 21 21 CD cord-302953-gr2kk9w4 33 40 , , , cord-302953-gr2kk9w4 33 41 22 22 CD cord-302953-gr2kk9w4 33 42 ] ] -RRB- cord-302953-gr2kk9w4 33 43 . . . cord-302953-gr2kk9w4 34 1 Membranes membrane NNS cord-302953-gr2kk9w4 34 2 were be VBD cord-302953-gr2kk9w4 34 3 incubated incubate VBN cord-302953-gr2kk9w4 34 4 with with IN cord-302953-gr2kk9w4 34 5 secondary secondary JJ cord-302953-gr2kk9w4 34 6 antibody antibody NN cord-302953-gr2kk9w4 34 7 diluted dilute VBN cord-302953-gr2kk9w4 34 8 in in IN cord-302953-gr2kk9w4 34 9 TBST TBST NNP cord-302953-gr2kk9w4 34 10 + + CC cord-302953-gr2kk9w4 34 11 5 5 CD cord-302953-gr2kk9w4 34 12 % % NN cord-302953-gr2kk9w4 34 13 nonfat nonfat JJ cord-302953-gr2kk9w4 34 14 milk milk NN cord-302953-gr2kk9w4 34 15 ( ( -LRB- cord-302953-gr2kk9w4 34 16 1:5000 1:5000 CD cord-302953-gr2kk9w4 34 17 horseradish horseradish NN cord-302953-gr2kk9w4 34 18 peroxidase peroxidase NN cord-302953-gr2kk9w4 34 19 ( ( -LRB- cord-302953-gr2kk9w4 34 20 HRP)-conjugated HRP)-conjugated NNP cord-302953-gr2kk9w4 34 21 donkey donkey NN cord-302953-gr2kk9w4 34 22 anti anti JJ cord-302953-gr2kk9w4 34 23 - - JJ cord-302953-gr2kk9w4 34 24 rabbit rabbit JJ cord-302953-gr2kk9w4 34 25 IgG igg NN cord-302953-gr2kk9w4 34 26 for for IN cord-302953-gr2kk9w4 34 27 nsp3 nsp3 NNS cord-302953-gr2kk9w4 34 28 and and CC cord-302953-gr2kk9w4 34 29 poly poly NN cord-302953-gr2kk9w4 34 30 - - HYPH cord-302953-gr2kk9w4 34 31 NSV nsv NN cord-302953-gr2kk9w4 34 32 ; ; : cord-302953-gr2kk9w4 34 33 1:5000 1:5000 CD cord-302953-gr2kk9w4 34 34 HRP HRP NNP cord-302953-gr2kk9w4 34 35 - - HYPH cord-302953-gr2kk9w4 34 36 conjugated conjugate VBN cord-302953-gr2kk9w4 34 37 sheep sheep NN cord-302953-gr2kk9w4 34 38 anti anti JJ cord-302953-gr2kk9w4 34 39 - - JJ cord-302953-gr2kk9w4 34 40 mouse mouse JJ cord-302953-gr2kk9w4 34 41 IgG IgG NNP cord-302953-gr2kk9w4 34 42 for for IN cord-302953-gr2kk9w4 34 43 β β NN cord-302953-gr2kk9w4 34 44 - - HYPH cord-302953-gr2kk9w4 34 45 actin actin NN cord-302953-gr2kk9w4 34 46 , , , cord-302953-gr2kk9w4 34 47 GE GE NNP cord-302953-gr2kk9w4 34 48 Healthcare Healthcare NNP cord-302953-gr2kk9w4 34 49 ) ) -RRB- cord-302953-gr2kk9w4 34 50 for for IN cord-302953-gr2kk9w4 34 51 1 1 CD cord-302953-gr2kk9w4 34 52 h h NN cord-302953-gr2kk9w4 34 53 on on IN cord-302953-gr2kk9w4 34 54 a a DT cord-302953-gr2kk9w4 34 55 rocker rocker NN cord-302953-gr2kk9w4 34 56 and and CC cord-302953-gr2kk9w4 34 57 developed develop VBD cord-302953-gr2kk9w4 34 58 using use VBG cord-302953-gr2kk9w4 34 59 Amersham Amersham NNP cord-302953-gr2kk9w4 34 60 ECL ECL NNP cord-302953-gr2kk9w4 34 61 Western Western NNP cord-302953-gr2kk9w4 34 62 Blotting Blotting NNP cord-302953-gr2kk9w4 34 63 Detection Detection NNP cord-302953-gr2kk9w4 34 64 Reagent Reagent NNP cord-302953-gr2kk9w4 34 65 ( ( -LRB- cord-302953-gr2kk9w4 34 66 GE GE NNP cord-302953-gr2kk9w4 34 67 Healthcare Healthcare NNP cord-302953-gr2kk9w4 34 68 ) ) -RRB- cord-302953-gr2kk9w4 34 69 according accord VBG cord-302953-gr2kk9w4 34 70 to to IN cord-302953-gr2kk9w4 34 71 manufacturer manufacturer NN cord-302953-gr2kk9w4 34 72 's 's POS cord-302953-gr2kk9w4 34 73 instructions instruction NNS cord-302953-gr2kk9w4 34 74 . . . cord-302953-gr2kk9w4 35 1 RNA RNA NNP cord-302953-gr2kk9w4 35 2 was be VBD cord-302953-gr2kk9w4 35 3 isolated isolate VBN cord-302953-gr2kk9w4 35 4 from from IN cord-302953-gr2kk9w4 35 5 dAP-7 dap-7 JJ cord-302953-gr2kk9w4 35 6 cells cell NNS cord-302953-gr2kk9w4 35 7 using use VBG cord-302953-gr2kk9w4 35 8 the the DT cord-302953-gr2kk9w4 35 9 Qiagen Qiagen NNP cord-302953-gr2kk9w4 35 10 RNeasy RNeasy NNP cord-302953-gr2kk9w4 35 11 ( ( -LRB- cord-302953-gr2kk9w4 35 12 Germantown Germantown NNP cord-302953-gr2kk9w4 35 13 , , , cord-302953-gr2kk9w4 35 14 MD MD NNP cord-302953-gr2kk9w4 35 15 , , , cord-302953-gr2kk9w4 35 16 USA USA NNP cord-302953-gr2kk9w4 35 17 ) ) -RRB- cord-302953-gr2kk9w4 35 18 or or CC cord-302953-gr2kk9w4 35 19 RNeasy RNeasy NNP cord-302953-gr2kk9w4 35 20 Plus Plus NNP cord-302953-gr2kk9w4 35 21 Mini Mini NNP cord-302953-gr2kk9w4 35 22 kit kit NN cord-302953-gr2kk9w4 35 23 following follow VBG cord-302953-gr2kk9w4 35 24 the the DT cord-302953-gr2kk9w4 35 25 manufacturer manufacturer NN cord-302953-gr2kk9w4 35 26 's 's POS cord-302953-gr2kk9w4 35 27 directions direction NNS cord-302953-gr2kk9w4 35 28 . . . cord-302953-gr2kk9w4 36 1 For for IN cord-302953-gr2kk9w4 36 2 mouse mouse NN cord-302953-gr2kk9w4 36 3 CNS CNS NNP cord-302953-gr2kk9w4 36 4 tissue tissue NN cord-302953-gr2kk9w4 36 5 , , , cord-302953-gr2kk9w4 36 6 right right JJ cord-302953-gr2kk9w4 36 7 brain brain NN cord-302953-gr2kk9w4 36 8 halves half NNS cord-302953-gr2kk9w4 36 9 or or CC cord-302953-gr2kk9w4 36 10 whole whole JJ cord-302953-gr2kk9w4 36 11 spinal spinal JJ cord-302953-gr2kk9w4 36 12 cords cord NNS cord-302953-gr2kk9w4 36 13 were be VBD cord-302953-gr2kk9w4 36 14 homogenized homogenize VBN cord-302953-gr2kk9w4 36 15 in in IN cord-302953-gr2kk9w4 36 16 one one CD cord-302953-gr2kk9w4 36 17 mL ml NN cord-302953-gr2kk9w4 37 1 QIAzol QIAzol NNP cord-302953-gr2kk9w4 37 2 in in IN cord-302953-gr2kk9w4 37 3 Lysing lyse VBG cord-302953-gr2kk9w4 37 4 Matrix Matrix NNP cord-302953-gr2kk9w4 37 5 D D NNP cord-302953-gr2kk9w4 37 6 tubes tube NNS cord-302953-gr2kk9w4 37 7 ( ( -LRB- cord-302953-gr2kk9w4 37 8 MP MP NNP cord-302953-gr2kk9w4 37 9 Biomedicals Biomedicals NNP cord-302953-gr2kk9w4 37 10 , , , cord-302953-gr2kk9w4 37 11 Irvine Irvine NNP cord-302953-gr2kk9w4 37 12 , , , cord-302953-gr2kk9w4 37 13 CA CA NNP cord-302953-gr2kk9w4 37 14 , , , cord-302953-gr2kk9w4 37 15 USA USA NNP cord-302953-gr2kk9w4 37 16 ) ) -RRB- cord-302953-gr2kk9w4 37 17 at at IN cord-302953-gr2kk9w4 37 18 6.0 6.0 CD cord-302953-gr2kk9w4 37 19 M M NNP cord-302953-gr2kk9w4 37 20 / / SYM cord-302953-gr2kk9w4 37 21 s s NN cord-302953-gr2kk9w4 37 22 for for IN cord-302953-gr2kk9w4 37 23 40 40 CD cord-302953-gr2kk9w4 37 24 s s NNS cord-302953-gr2kk9w4 37 25 using use VBG cord-302953-gr2kk9w4 37 26 a a DT cord-302953-gr2kk9w4 37 27 FastPrep-24 FastPrep-24 NNPS cord-302953-gr2kk9w4 37 28 homogenizer homogenizer NN cord-302953-gr2kk9w4 37 29 ( ( -LRB- cord-302953-gr2kk9w4 37 30 MP MP NNP cord-302953-gr2kk9w4 37 31 Biomedicals Biomedicals NNP cord-302953-gr2kk9w4 37 32 ) ) -RRB- cord-302953-gr2kk9w4 37 33 . . . cord-302953-gr2kk9w4 38 1 The the DT cord-302953-gr2kk9w4 38 2 Qiagen Qiagen NNP cord-302953-gr2kk9w4 38 3 RNeasy RNeasy NNP cord-302953-gr2kk9w4 38 4 Lipid Lipid NNP cord-302953-gr2kk9w4 38 5 Tissue Tissue NNP cord-302953-gr2kk9w4 38 6 Mini Mini NNP cord-302953-gr2kk9w4 38 7 kit kit NN cord-302953-gr2kk9w4 38 8 was be VBD cord-302953-gr2kk9w4 38 9 used use VBN cord-302953-gr2kk9w4 38 10 to to TO cord-302953-gr2kk9w4 38 11 isolate isolate VB cord-302953-gr2kk9w4 38 12 RNA RNA NNP cord-302953-gr2kk9w4 38 13 , , , cord-302953-gr2kk9w4 38 14 and and CC cord-302953-gr2kk9w4 38 15 cDNA cdna NN cord-302953-gr2kk9w4 38 16 was be VBD cord-302953-gr2kk9w4 38 17 synthesized synthesize VBN cord-302953-gr2kk9w4 38 18 using use VBG cord-302953-gr2kk9w4 38 19 a a DT cord-302953-gr2kk9w4 38 20 High High NNP cord-302953-gr2kk9w4 38 21 Capacity Capacity NNP cord-302953-gr2kk9w4 38 22 cDNA cdna NN cord-302953-gr2kk9w4 38 23 Reverse Reverse NNP cord-302953-gr2kk9w4 38 24 Transcription Transcription NNP cord-302953-gr2kk9w4 38 25 Kit kit NN cord-302953-gr2kk9w4 38 26 with with IN cord-302953-gr2kk9w4 38 27 random random JJ cord-302953-gr2kk9w4 38 28 primers primer NNS cord-302953-gr2kk9w4 38 29 ( ( -LRB- cord-302953-gr2kk9w4 38 30 Life Life NNP cord-302953-gr2kk9w4 38 31 Technologies Technologies NNPS cord-302953-gr2kk9w4 38 32 , , , cord-302953-gr2kk9w4 38 33 Carlsbad Carlsbad NNP cord-302953-gr2kk9w4 38 34 , , , cord-302953-gr2kk9w4 38 35 CA CA NNP cord-302953-gr2kk9w4 38 36 , , , cord-302953-gr2kk9w4 38 37 USA USA NNP cord-302953-gr2kk9w4 38 38 ) ) -RRB- cord-302953-gr2kk9w4 38 39 , , , cord-302953-gr2kk9w4 38 40 and and CC cord-302953-gr2kk9w4 38 41 quantitative quantitative JJ cord-302953-gr2kk9w4 38 42 real real JJ cord-302953-gr2kk9w4 38 43 - - HYPH cord-302953-gr2kk9w4 38 44 time time NN cord-302953-gr2kk9w4 38 45 PCR PCR NNP cord-302953-gr2kk9w4 38 46 ( ( -LRB- cord-302953-gr2kk9w4 38 47 qRT qRT NNP cord-302953-gr2kk9w4 38 48 - - HYPH cord-302953-gr2kk9w4 38 49 PCR PCR NNP cord-302953-gr2kk9w4 38 50 ) ) -RRB- cord-302953-gr2kk9w4 38 51 was be VBD cord-302953-gr2kk9w4 38 52 performed perform VBN cord-302953-gr2kk9w4 38 53 using use VBG cord-302953-gr2kk9w4 38 54 TaqMan TaqMan NNP cord-302953-gr2kk9w4 38 55 Universal Universal NNP cord-302953-gr2kk9w4 38 56 PCR PCR NNP cord-302953-gr2kk9w4 38 57 Master Master NNP cord-302953-gr2kk9w4 38 58 Mix Mix NNP cord-302953-gr2kk9w4 38 59 ( ( -LRB- cord-302953-gr2kk9w4 38 60 Roche Roche NNP cord-302953-gr2kk9w4 38 61 , , , cord-302953-gr2kk9w4 38 62 Indianapolis Indianapolis NNP cord-302953-gr2kk9w4 38 63 , , , cord-302953-gr2kk9w4 38 64 IN IN NNP cord-302953-gr2kk9w4 38 65 , , , cord-302953-gr2kk9w4 38 66 USA USA NNP cord-302953-gr2kk9w4 38 67 ) ) -RRB- cord-302953-gr2kk9w4 38 68 on on IN cord-302953-gr2kk9w4 38 69 a a DT cord-302953-gr2kk9w4 38 70 7500 7500 CD cord-302953-gr2kk9w4 38 71 Fast Fast NNP cord-302953-gr2kk9w4 38 72 Real real JJ cord-302953-gr2kk9w4 38 73 - - HYPH cord-302953-gr2kk9w4 38 74 Time time NN cord-302953-gr2kk9w4 38 75 PCR PCR NNP cord-302953-gr2kk9w4 38 76 System System NNP cord-302953-gr2kk9w4 38 77 . . . cord-302953-gr2kk9w4 39 1 SINV SINV NNP cord-302953-gr2kk9w4 39 2 RNA RNA NNP cord-302953-gr2kk9w4 39 3 copies copy NNS cord-302953-gr2kk9w4 39 4 were be VBD cord-302953-gr2kk9w4 39 5 measured measure VBN cord-302953-gr2kk9w4 39 6 using use VBG cord-302953-gr2kk9w4 39 7 TaqMan TaqMan NNP cord-302953-gr2kk9w4 39 8 probe probe NN cord-302953-gr2kk9w4 39 9 ( ( -LRB- cord-302953-gr2kk9w4 39 10 5 5 CD cord-302953-gr2kk9w4 39 11 -6-carboxyfluorescein -6-carboxyfluorescein NN cord-302953-gr2kk9w4 40 1 ( ( -LRB- cord-302953-gr2kk9w4 40 2 FAM)-CGCATACAGACTTCCGCCCAGT-6-carboxytetra FAM)-CGCATACAGACTTCCGCCCAGT-6-carboxytetra NNP cord-302953-gr2kk9w4 40 3 - - HYPH cord-302953-gr2kk9w4 40 4 methylrhodamine methylrhodamine NNP cord-302953-gr2kk9w4 40 5 ( ( -LRB- cord-302953-gr2kk9w4 40 6 TAMRA)-3 tamra)-3 NN cord-302953-gr2kk9w4 40 7 , , , cord-302953-gr2kk9w4 40 8 Applied Applied NNP cord-302953-gr2kk9w4 40 9 Biosystems Biosystems NNP cord-302953-gr2kk9w4 40 10 , , , cord-302953-gr2kk9w4 40 11 Waltham Waltham NNP cord-302953-gr2kk9w4 40 12 , , , cord-302953-gr2kk9w4 40 13 MA MA NNP cord-302953-gr2kk9w4 40 14 , , , cord-302953-gr2kk9w4 40 15 USA USA NNP cord-302953-gr2kk9w4 40 16 ) ) -RRB- cord-302953-gr2kk9w4 40 17 with with IN cord-302953-gr2kk9w4 40 18 primers primer NNS cord-302953-gr2kk9w4 40 19 to to IN cord-302953-gr2kk9w4 40 20 the the DT cord-302953-gr2kk9w4 40 21 SINV SINV NNP cord-302953-gr2kk9w4 40 22 E2 E2 NNP cord-302953-gr2kk9w4 40 23 gene gene NN cord-302953-gr2kk9w4 40 24 ( ( -LRB- cord-302953-gr2kk9w4 40 25 forward forward RB cord-302953-gr2kk9w4 40 26 , , . cord-302953-gr2kk9w4 41 1 5 5 LS cord-302953-gr2kk9w4 41 2 -TGGGACGAAGCGGACGATAA-3 -tgggacgaagcggacgataa-3 NN cord-302953-gr2kk9w4 41 3 ; ; : cord-302953-gr2kk9w4 41 4 reverse reverse VB cord-302953-gr2kk9w4 41 5 , , , cord-302953-gr2kk9w4 41 6 5 5 CD cord-302953-gr2kk9w4 41 7 -CTGCTCCGCTTTGGTCGTAT-3 -CTGCTCCGCTTTGGTCGTAT-3 NNP cord-302953-gr2kk9w4 41 8 ) ) -RRB- cord-302953-gr2kk9w4 41 9 . . . cord-302953-gr2kk9w4 42 1 SINV SINV NNP cord-302953-gr2kk9w4 42 2 E2 E2 NNP cord-302953-gr2kk9w4 42 3 copies copy NNS cord-302953-gr2kk9w4 42 4 were be VBD cord-302953-gr2kk9w4 42 5 quantified quantify VBN cord-302953-gr2kk9w4 42 6 using use VBG cord-302953-gr2kk9w4 42 7 a a DT cord-302953-gr2kk9w4 42 8 standard standard JJ cord-302953-gr2kk9w4 42 9 curve curve NN cord-302953-gr2kk9w4 42 10 made make VBN cord-302953-gr2kk9w4 42 11 of of IN cord-302953-gr2kk9w4 42 12 ten ten RB cord-302953-gr2kk9w4 42 13 - - HYPH cord-302953-gr2kk9w4 42 14 fold fold JJ cord-302953-gr2kk9w4 42 15 dilutions dilution NNS cord-302953-gr2kk9w4 42 16 of of IN cord-302953-gr2kk9w4 42 17 a a DT cord-302953-gr2kk9w4 42 18 plasmid plasmid NN cord-302953-gr2kk9w4 42 19 containing contain VBG cord-302953-gr2kk9w4 42 20 the the DT cord-302953-gr2kk9w4 42 21 SINV SINV NNP cord-302953-gr2kk9w4 42 22 subgenomic subgenomic NNP cord-302953-gr2kk9w4 42 23 region region NN cord-302953-gr2kk9w4 42 24 genes gene NNS cord-302953-gr2kk9w4 42 25 and and CC cord-302953-gr2kk9w4 42 26 normalized normalize VBN cord-302953-gr2kk9w4 42 27 to to IN cord-302953-gr2kk9w4 42 28 endogenous endogenous JJ cord-302953-gr2kk9w4 42 29 rodent rodent NN cord-302953-gr2kk9w4 42 30 Gapdh Gapdh NNP cord-302953-gr2kk9w4 42 31 . . . cord-302953-gr2kk9w4 43 1 mRNA mRNA NNP cord-302953-gr2kk9w4 43 2 was be VBD cord-302953-gr2kk9w4 43 3 measured measure VBN cord-302953-gr2kk9w4 43 4 using use VBG cord-302953-gr2kk9w4 43 5 commercially commercially RB cord-302953-gr2kk9w4 43 6 available available JJ cord-302953-gr2kk9w4 43 7 TaqMan TaqMan NNP cord-302953-gr2kk9w4 43 8 gene gene NN cord-302953-gr2kk9w4 43 9 expression expression NN cord-302953-gr2kk9w4 43 10 assays assay NNS cord-302953-gr2kk9w4 43 11 ( ( -LRB- cord-302953-gr2kk9w4 43 12 Applied Applied NNP cord-302953-gr2kk9w4 43 13 Biosystems Biosystems NNP cord-302953-gr2kk9w4 43 14 or or CC cord-302953-gr2kk9w4 43 15 Integrated Integrated NNP cord-302953-gr2kk9w4 43 16 DNA DNA NNP cord-302953-gr2kk9w4 43 17 Technologies Technologies NNP cord-302953-gr2kk9w4 43 18 , , , cord-302953-gr2kk9w4 43 19 Coralville Coralville NNP cord-302953-gr2kk9w4 43 20 , , , cord-302953-gr2kk9w4 43 21 IA IA NNP cord-302953-gr2kk9w4 43 22 , , , cord-302953-gr2kk9w4 43 23 USA USA NNP cord-302953-gr2kk9w4 43 24 ) ) -RRB- cord-302953-gr2kk9w4 43 25 , , , cord-302953-gr2kk9w4 43 26 and and CC cord-302953-gr2kk9w4 43 27 relative relative JJ cord-302953-gr2kk9w4 43 28 quantification quantification NN cord-302953-gr2kk9w4 43 29 was be VBD cord-302953-gr2kk9w4 43 30 performed perform VBN cord-302953-gr2kk9w4 43 31 by by IN cord-302953-gr2kk9w4 43 32 the the DT cord-302953-gr2kk9w4 43 33 ∆∆CT ∆∆ct NN cord-302953-gr2kk9w4 43 34 method method NN cord-302953-gr2kk9w4 43 35 using use VBG cord-302953-gr2kk9w4 43 36 endogenous endogenous JJ cord-302953-gr2kk9w4 43 37 rodent rodent NN cord-302953-gr2kk9w4 43 38 Gapdh Gapdh NNP cord-302953-gr2kk9w4 43 39 mRNA mRNA NNP cord-302953-gr2kk9w4 43 40 for for IN cord-302953-gr2kk9w4 43 41 normalization normalization NN cord-302953-gr2kk9w4 43 42 . . . cord-302953-gr2kk9w4 43 43 _SP cord-302953-gr2kk9w4 44 1 Single single JJ cord-302953-gr2kk9w4 44 2 cell cell NN cord-302953-gr2kk9w4 44 3 suspensions suspension NNS cord-302953-gr2kk9w4 44 4 were be VBD cord-302953-gr2kk9w4 44 5 made make VBN cord-302953-gr2kk9w4 44 6 from from IN cord-302953-gr2kk9w4 44 7 CLNs cln NNS cord-302953-gr2kk9w4 44 8 , , , cord-302953-gr2kk9w4 44 9 brains brain NNS cord-302953-gr2kk9w4 44 10 , , , cord-302953-gr2kk9w4 44 11 and and CC cord-302953-gr2kk9w4 44 12 spinal spinal JJ cord-302953-gr2kk9w4 44 13 cords cord NNS cord-302953-gr2kk9w4 44 14 pooled pool VBD cord-302953-gr2kk9w4 44 15 from from IN cord-302953-gr2kk9w4 44 16 3 3 CD cord-302953-gr2kk9w4 44 17 to to TO cord-302953-gr2kk9w4 44 18 9 9 CD cord-302953-gr2kk9w4 44 19 mice mouse NNS cord-302953-gr2kk9w4 44 20 per per IN cord-302953-gr2kk9w4 44 21 strain strain NN cord-302953-gr2kk9w4 44 22 per per IN cord-302953-gr2kk9w4 44 23 time time NN cord-302953-gr2kk9w4 44 24 point point NN cord-302953-gr2kk9w4 44 25 as as IN cord-302953-gr2kk9w4 44 26 previously previously RB cord-302953-gr2kk9w4 44 27 described describe VBN cord-302953-gr2kk9w4 44 28 [ [ -LRB- cord-302953-gr2kk9w4 44 29 9 9 CD cord-302953-gr2kk9w4 44 30 ] ] -RRB- cord-302953-gr2kk9w4 44 31 . . . cord-302953-gr2kk9w4 45 1 Briefly briefly RB cord-302953-gr2kk9w4 45 2 , , , cord-302953-gr2kk9w4 45 3 CLNs cln NNS cord-302953-gr2kk9w4 45 4 were be VBD cord-302953-gr2kk9w4 45 5 dissociated dissociate VBN cord-302953-gr2kk9w4 45 6 using use VBG cord-302953-gr2kk9w4 45 7 gentleMACS gentleMACS NNP cord-302953-gr2kk9w4 45 8 C c NN cord-302953-gr2kk9w4 45 9 tubes tube NNS cord-302953-gr2kk9w4 45 10 and and CC cord-302953-gr2kk9w4 45 11 Dissociator Dissociator NNP cord-302953-gr2kk9w4 45 12 ( ( -LRB- cord-302953-gr2kk9w4 45 13 Miltenyi Miltenyi NNP cord-302953-gr2kk9w4 45 14 Biotech Biotech NNP cord-302953-gr2kk9w4 45 15 , , , cord-302953-gr2kk9w4 45 16 Auburn Auburn NNP cord-302953-gr2kk9w4 45 17 , , , cord-302953-gr2kk9w4 45 18 CA CA NNP cord-302953-gr2kk9w4 45 19 , , , cord-302953-gr2kk9w4 45 20 USA USA NNP cord-302953-gr2kk9w4 45 21 ) ) -RRB- cord-302953-gr2kk9w4 45 22 , , , cord-302953-gr2kk9w4 45 23 and and CC cord-302953-gr2kk9w4 45 24 red red JJ cord-302953-gr2kk9w4 45 25 blood blood NN cord-302953-gr2kk9w4 45 26 cells cell NNS cord-302953-gr2kk9w4 45 27 were be VBD cord-302953-gr2kk9w4 45 28 lysed lyse VBN cord-302953-gr2kk9w4 45 29 with with IN cord-302953-gr2kk9w4 45 30 an an DT cord-302953-gr2kk9w4 45 31 ammonium ammonium NN cord-302953-gr2kk9w4 45 32 chloride chloride NN cord-302953-gr2kk9w4 45 33 solution solution NN cord-302953-gr2kk9w4 45 34 ( ( -LRB- cord-302953-gr2kk9w4 45 35 Sigma Sigma NNP cord-302953-gr2kk9w4 45 36 - - HYPH cord-302953-gr2kk9w4 45 37 Aldrich Aldrich NNP cord-302953-gr2kk9w4 45 38 , , , cord-302953-gr2kk9w4 45 39 St. St. NNP cord-302953-gr2kk9w4 45 40 Louis Louis NNP cord-302953-gr2kk9w4 45 41 , , , cord-302953-gr2kk9w4 45 42 MO MO NNP cord-302953-gr2kk9w4 45 43 , , , cord-302953-gr2kk9w4 45 44 USA USA NNP cord-302953-gr2kk9w4 45 45 or or CC cord-302953-gr2kk9w4 45 46 eBioscience eBioscience NNP cord-302953-gr2kk9w4 45 47 , , , cord-302953-gr2kk9w4 45 48 San San NNP cord-302953-gr2kk9w4 45 49 Diego Diego NNP cord-302953-gr2kk9w4 45 50 , , , cord-302953-gr2kk9w4 45 51 CA CA NNP cord-302953-gr2kk9w4 45 52 , , , cord-302953-gr2kk9w4 45 53 USA USA NNP cord-302953-gr2kk9w4 45 54 ) ) -RRB- cord-302953-gr2kk9w4 45 55 . . . cord-302953-gr2kk9w4 46 1 Brains brain NNS cord-302953-gr2kk9w4 46 2 and and CC cord-302953-gr2kk9w4 46 3 spinal spinal JJ cord-302953-gr2kk9w4 46 4 cords cord NNS cord-302953-gr2kk9w4 46 5 were be VBD cord-302953-gr2kk9w4 46 6 dissociated dissociate VBN cord-302953-gr2kk9w4 46 7 in in IN cord-302953-gr2kk9w4 46 8 a a DT cord-302953-gr2kk9w4 46 9 solution solution NN cord-302953-gr2kk9w4 46 10 containing contain VBG cord-302953-gr2kk9w4 46 11 collagenase collagenase NNP cord-302953-gr2kk9w4 46 12 D D NNP cord-302953-gr2kk9w4 46 13 ( ( -LRB- cord-302953-gr2kk9w4 46 14 Roche Roche NNP cord-302953-gr2kk9w4 46 15 ) ) -RRB- cord-302953-gr2kk9w4 46 16 or or CC cord-302953-gr2kk9w4 46 17 collagenase collagenase NNP cord-302953-gr2kk9w4 46 18 IV IV NNP cord-302953-gr2kk9w4 46 19 ( ( -LRB- cord-302953-gr2kk9w4 46 20 Worthington Worthington NNP cord-302953-gr2kk9w4 46 21 Labs Labs NNP cord-302953-gr2kk9w4 46 22 , , , cord-302953-gr2kk9w4 46 23 Worthington Worthington NNP cord-302953-gr2kk9w4 46 24 , , , cord-302953-gr2kk9w4 46 25 OH oh UH cord-302953-gr2kk9w4 46 26 , , , cord-302953-gr2kk9w4 46 27 USA USA NNP cord-302953-gr2kk9w4 46 28 ) ) -RRB- cord-302953-gr2kk9w4 46 29 and and CC cord-302953-gr2kk9w4 46 30 DNase DNase NNP cord-302953-gr2kk9w4 46 31 I i NN cord-302953-gr2kk9w4 46 32 ( ( -LRB- cord-302953-gr2kk9w4 46 33 Roche Roche NNP cord-302953-gr2kk9w4 46 34 ) ) -RRB- cord-302953-gr2kk9w4 46 35 , , , cord-302953-gr2kk9w4 46 36 and and CC cord-302953-gr2kk9w4 46 37 mononuclear mononuclear NN cord-302953-gr2kk9w4 46 38 cells cell NNS cord-302953-gr2kk9w4 46 39 were be VBD cord-302953-gr2kk9w4 46 40 separated separate VBN cord-302953-gr2kk9w4 46 41 on on IN cord-302953-gr2kk9w4 46 42 a a DT cord-302953-gr2kk9w4 46 43 supplemented supplement VBN cord-302953-gr2kk9w4 46 44 Percoll Percoll NNP cord-302953-gr2kk9w4 46 45 gradient gradient NN cord-302953-gr2kk9w4 46 46 . . . cord-302953-gr2kk9w4 47 1 Live live JJ cord-302953-gr2kk9w4 47 2 mononuclear mononuclear JJ cord-302953-gr2kk9w4 47 3 cells cell NNS cord-302953-gr2kk9w4 47 4 were be VBD cord-302953-gr2kk9w4 47 5 quantified quantify VBN cord-302953-gr2kk9w4 47 6 using use VBG cord-302953-gr2kk9w4 47 7 trypan trypan NNP cord-302953-gr2kk9w4 47 8 blue blue JJ cord-302953-gr2kk9w4 47 9 exclusion exclusion NN cord-302953-gr2kk9w4 47 10 . . . cord-302953-gr2kk9w4 48 1 For for IN cord-302953-gr2kk9w4 48 2 degranulation degranulation NN cord-302953-gr2kk9w4 48 3 assessment assessment NN cord-302953-gr2kk9w4 48 4 , , , cord-302953-gr2kk9w4 48 5 2 2 CD cord-302953-gr2kk9w4 48 6 - - SYM cord-302953-gr2kk9w4 48 7 3 3 CD cord-302953-gr2kk9w4 48 8 × × NN cord-302953-gr2kk9w4 48 9 10 10 CD cord-302953-gr2kk9w4 48 10 6 6 CD cord-302953-gr2kk9w4 48 11 cells cell NNS cord-302953-gr2kk9w4 48 12 were be VBD cord-302953-gr2kk9w4 48 13 stimulated stimulate VBN cord-302953-gr2kk9w4 48 14 for for IN cord-302953-gr2kk9w4 48 15 4 4 CD cord-302953-gr2kk9w4 48 16 h h NN cord-302953-gr2kk9w4 48 17 at at IN cord-302953-gr2kk9w4 48 18 37 37 CD cord-302953-gr2kk9w4 48 19 • • NN cord-302953-gr2kk9w4 48 20 C c NN cord-302953-gr2kk9w4 48 21 with with IN cord-302953-gr2kk9w4 48 22 50 50 CD cord-302953-gr2kk9w4 48 23 ng ng NN cord-302953-gr2kk9w4 48 24 / / SYM cord-302953-gr2kk9w4 48 25 mL ml NN cord-302953-gr2kk9w4 48 26 of of IN cord-302953-gr2kk9w4 48 27 phorbol-12-myristate phorbol-12-myristate NNP cord-302953-gr2kk9w4 48 28 13-acetate 13-acetate CD cord-302953-gr2kk9w4 49 1 ( ( -LRB- cord-302953-gr2kk9w4 49 2 PMA PMA NNP cord-302953-gr2kk9w4 49 3 , , , cord-302953-gr2kk9w4 49 4 Sigma Sigma NNP cord-302953-gr2kk9w4 49 5 ) ) -RRB- cord-302953-gr2kk9w4 49 6 , , , cord-302953-gr2kk9w4 49 7 1 1 CD cord-302953-gr2kk9w4 49 8 µg µg NN cord-302953-gr2kk9w4 49 9 / / SYM cord-302953-gr2kk9w4 49 10 mL ml NN cord-302953-gr2kk9w4 49 11 ionomycin ionomycin NNS cord-302953-gr2kk9w4 49 12 ( ( -LRB- cord-302953-gr2kk9w4 49 13 Sigma Sigma NNP cord-302953-gr2kk9w4 49 14 ) ) -RRB- cord-302953-gr2kk9w4 49 15 , , , cord-302953-gr2kk9w4 49 16 and and CC cord-302953-gr2kk9w4 49 17 antibody antibody NN cord-302953-gr2kk9w4 49 18 against against IN cord-302953-gr2kk9w4 49 19 CD107a CD107a NNP cord-302953-gr2kk9w4 49 20 ( ( -LRB- cord-302953-gr2kk9w4 49 21 clone clone JJ cord-302953-gr2kk9w4 49 22 eBio1D4B ebio1d4b NN cord-302953-gr2kk9w4 49 23 , , , cord-302953-gr2kk9w4 49 24 eBioscience eBioscience NNP cord-302953-gr2kk9w4 49 25 ) ) -RRB- cord-302953-gr2kk9w4 49 26 in in IN cord-302953-gr2kk9w4 49 27 RPMI RPMI NNP cord-302953-gr2kk9w4 49 28 + + SYM cord-302953-gr2kk9w4 49 29 10 10 CD cord-302953-gr2kk9w4 49 30 % % NN cord-302953-gr2kk9w4 49 31 FBS FBS NNP cord-302953-gr2kk9w4 49 32 . . . cord-302953-gr2kk9w4 50 1 After after IN cord-302953-gr2kk9w4 50 2 1 1 CD cord-302953-gr2kk9w4 50 3 h h NN cord-302953-gr2kk9w4 50 4 , , , cord-302953-gr2kk9w4 50 5 monensin monensin NNP cord-302953-gr2kk9w4 50 6 ( ( -LRB- cord-302953-gr2kk9w4 50 7 GolgiStop GolgiStop NNP cord-302953-gr2kk9w4 50 8 , , , cord-302953-gr2kk9w4 50 9 1:2000 1:2000 CD cord-302953-gr2kk9w4 50 10 , , , cord-302953-gr2kk9w4 50 11 BD BD NNP cord-302953-gr2kk9w4 50 12 Pharmingen Pharmingen NNP cord-302953-gr2kk9w4 50 13 , , , cord-302953-gr2kk9w4 50 14 Franklin Franklin NNP cord-302953-gr2kk9w4 50 15 Lakes Lakes NNP cord-302953-gr2kk9w4 50 16 , , , cord-302953-gr2kk9w4 50 17 NJ NJ NNP cord-302953-gr2kk9w4 50 18 , , , cord-302953-gr2kk9w4 50 19 USA USA NNP cord-302953-gr2kk9w4 50 20 ) ) -RRB- cord-302953-gr2kk9w4 50 21 was be VBD cord-302953-gr2kk9w4 50 22 added add VBN cord-302953-gr2kk9w4 50 23 to to TO cord-302953-gr2kk9w4 50 24 block block VB cord-302953-gr2kk9w4 50 25 cellular cellular JJ cord-302953-gr2kk9w4 50 26 protein protein NN cord-302953-gr2kk9w4 50 27 transport transport NN cord-302953-gr2kk9w4 50 28 . . . cord-302953-gr2kk9w4 51 1 For for IN cord-302953-gr2kk9w4 51 2 intracytoplasmic intracytoplasmic JJ cord-302953-gr2kk9w4 51 3 cytokine cytokine NN cord-302953-gr2kk9w4 51 4 staining staining NN cord-302953-gr2kk9w4 51 5 ( ( -LRB- cord-302953-gr2kk9w4 51 6 ICS ICS NNP cord-302953-gr2kk9w4 51 7 ) ) -RRB- cord-302953-gr2kk9w4 51 8 , , , cord-302953-gr2kk9w4 51 9 2 2 CD cord-302953-gr2kk9w4 51 10 - - SYM cord-302953-gr2kk9w4 51 11 3 3 CD cord-302953-gr2kk9w4 51 12 × × NN cord-302953-gr2kk9w4 51 13 10 10 CD cord-302953-gr2kk9w4 51 14 6 6 CD cord-302953-gr2kk9w4 51 15 cells cell NNS cord-302953-gr2kk9w4 51 16 were be VBD cord-302953-gr2kk9w4 51 17 stimulated stimulate VBN cord-302953-gr2kk9w4 51 18 for for IN cord-302953-gr2kk9w4 51 19 4 4 CD cord-302953-gr2kk9w4 51 20 h h NN cord-302953-gr2kk9w4 51 21 at at IN cord-302953-gr2kk9w4 51 22 37 37 CD cord-302953-gr2kk9w4 51 23 • • NN cord-302953-gr2kk9w4 51 24 C c NN cord-302953-gr2kk9w4 51 25 with with IN cord-302953-gr2kk9w4 51 26 50 50 CD cord-302953-gr2kk9w4 51 27 ng ng NN cord-302953-gr2kk9w4 51 28 / / SYM cord-302953-gr2kk9w4 51 29 mL ml NN cord-302953-gr2kk9w4 51 30 PMA PMA NNP cord-302953-gr2kk9w4 51 31 and and CC cord-302953-gr2kk9w4 51 32 1 1 CD cord-302953-gr2kk9w4 51 33 µg µg NN cord-302953-gr2kk9w4 51 34 / / SYM cord-302953-gr2kk9w4 51 35 mL ml NN cord-302953-gr2kk9w4 51 36 ionomycin ionomycin NNS cord-302953-gr2kk9w4 51 37 in in IN cord-302953-gr2kk9w4 51 38 the the DT cord-302953-gr2kk9w4 51 39 presence presence NN cord-302953-gr2kk9w4 51 40 of of IN cord-302953-gr2kk9w4 51 41 brefeldin brefeldin NNP cord-302953-gr2kk9w4 51 42 A A NNP cord-302953-gr2kk9w4 51 43 ( ( -LRB- cord-302953-gr2kk9w4 51 44 GolgiPlug GolgiPlug NNP cord-302953-gr2kk9w4 51 45 , , , cord-302953-gr2kk9w4 51 46 BD BD NNP cord-302953-gr2kk9w4 51 47 Pharmingen Pharmingen NNP cord-302953-gr2kk9w4 51 48 ) ) -RRB- cord-302953-gr2kk9w4 51 49 in in IN cord-302953-gr2kk9w4 51 50 RPMI RPMI NNP cord-302953-gr2kk9w4 51 51 + + SYM cord-302953-gr2kk9w4 51 52 1 1 CD cord-302953-gr2kk9w4 51 53 % % NN cord-302953-gr2kk9w4 51 54 FBS FBS NNP cord-302953-gr2kk9w4 51 55 . . . cord-302953-gr2kk9w4 52 1 Following follow VBG cord-302953-gr2kk9w4 52 2 LIVE live RB cord-302953-gr2kk9w4 52 3 / / SYM cord-302953-gr2kk9w4 52 4 DEAD dead JJ cord-302953-gr2kk9w4 52 5 and and CC cord-302953-gr2kk9w4 52 6 surface surface NN cord-302953-gr2kk9w4 52 7 antibody antibody NN cord-302953-gr2kk9w4 52 8 staining staining NN cord-302953-gr2kk9w4 52 9 ( ( -LRB- cord-302953-gr2kk9w4 52 10 see see VB cord-302953-gr2kk9w4 52 11 above above RB cord-302953-gr2kk9w4 52 12 ) ) -RRB- cord-302953-gr2kk9w4 52 13 , , , cord-302953-gr2kk9w4 52 14 cells cell NNS cord-302953-gr2kk9w4 52 15 were be VBD cord-302953-gr2kk9w4 52 16 fixed fix VBN cord-302953-gr2kk9w4 52 17 for for IN cord-302953-gr2kk9w4 52 18 20 20 CD cord-302953-gr2kk9w4 52 19 min min NN cord-302953-gr2kk9w4 52 20 using use VBG cord-302953-gr2kk9w4 52 21 Fixation Fixation NNP cord-302953-gr2kk9w4 52 22 / / SYM cord-302953-gr2kk9w4 52 23 Permeabilization Permeabilization NNP cord-302953-gr2kk9w4 52 24 solution solution NN cord-302953-gr2kk9w4 52 25 from from IN cord-302953-gr2kk9w4 52 26 the the DT cord-302953-gr2kk9w4 52 27 BD BD NNP cord-302953-gr2kk9w4 52 28 Cytofix Cytofix NNP cord-302953-gr2kk9w4 52 29 / / SYM cord-302953-gr2kk9w4 52 30 Cytoperm Cytoperm NNP cord-302953-gr2kk9w4 52 31 kit kit NN cord-302953-gr2kk9w4 52 32 . . . cord-302953-gr2kk9w4 53 1 Cells cell NNS cord-302953-gr2kk9w4 53 2 were be VBD cord-302953-gr2kk9w4 53 3 stained stain VBN cord-302953-gr2kk9w4 53 4 for for IN cord-302953-gr2kk9w4 53 5 30 30 CD cord-302953-gr2kk9w4 53 6 min min NN cord-302953-gr2kk9w4 53 7 on on IN cord-302953-gr2kk9w4 53 8 ice ice NN cord-302953-gr2kk9w4 53 9 with with IN cord-302953-gr2kk9w4 53 10 monoclonal monoclonal JJ cord-302953-gr2kk9w4 53 11 antibodies antibody NNS cord-302953-gr2kk9w4 53 12 against against IN cord-302953-gr2kk9w4 53 13 IFN IFN NNP cord-302953-gr2kk9w4 53 14 - - HYPH cord-302953-gr2kk9w4 53 15 γ γ NNP cord-302953-gr2kk9w4 53 16 ( ( -LRB- cord-302953-gr2kk9w4 53 17 clone clone JJ cord-302953-gr2kk9w4 53 18 XMG1.2 XMG1.2 NNP cord-302953-gr2kk9w4 53 19 ) ) -RRB- cord-302953-gr2kk9w4 53 20 , , , cord-302953-gr2kk9w4 53 21 IL-4 IL-4 NNP cord-302953-gr2kk9w4 53 22 ( ( -LRB- cord-302953-gr2kk9w4 53 23 clone clone NNP cord-302953-gr2kk9w4 53 24 11B11 11b11 CD cord-302953-gr2kk9w4 53 25 ) ) -RRB- cord-302953-gr2kk9w4 53 26 , , , cord-302953-gr2kk9w4 53 27 IL-17a IL-17a NNP cord-302953-gr2kk9w4 53 28 ( ( -LRB- cord-302953-gr2kk9w4 53 29 clone clone VB cord-302953-gr2kk9w4 53 30 eBio17B7 eBio17B7 NNP cord-302953-gr2kk9w4 53 31 ) ) -RRB- cord-302953-gr2kk9w4 53 32 , , , cord-302953-gr2kk9w4 53 33 granzyme granzyme NNP cord-302953-gr2kk9w4 53 34 B B NNP cord-302953-gr2kk9w4 53 35 ( ( -LRB- cord-302953-gr2kk9w4 53 36 clone clone VB cord-302953-gr2kk9w4 53 37 NGZB NGZB NNP cord-302953-gr2kk9w4 53 38 ) ) -RRB- cord-302953-gr2kk9w4 53 39 , , , cord-302953-gr2kk9w4 53 40 granzyme granzyme VBZ cord-302953-gr2kk9w4 53 41 A A NNP cord-302953-gr2kk9w4 53 42 ( ( -LRB- cord-302953-gr2kk9w4 53 43 clone clone NN cord-302953-gr2kk9w4 53 44 GzA-3G8.5 GzA-3G8.5 NNP cord-302953-gr2kk9w4 53 45 ) ) -RRB- cord-302953-gr2kk9w4 53 46 , , , cord-302953-gr2kk9w4 53 47 GM GM NNP cord-302953-gr2kk9w4 53 48 - - HYPH cord-302953-gr2kk9w4 53 49 CSF CSF NNP cord-302953-gr2kk9w4 53 50 ( ( -LRB- cord-302953-gr2kk9w4 53 51 clone clone VBN cord-302953-gr2kk9w4 53 52 MPI-22E9 MPI-22E9 NNP cord-302953-gr2kk9w4 53 53 ) ) -RRB- cord-302953-gr2kk9w4 53 54 , , , cord-302953-gr2kk9w4 53 55 and and CC cord-302953-gr2kk9w4 53 56 TNF TNF NNP cord-302953-gr2kk9w4 53 57 - - HYPH cord-302953-gr2kk9w4 53 58 α α NNP cord-302953-gr2kk9w4 53 59 ( ( -LRB- cord-302953-gr2kk9w4 53 60 clone clone NN cord-302953-gr2kk9w4 53 61 MP6-XT22 MP6-XT22 VBD cord-302953-gr2kk9w4 53 62 ) ) -RRB- cord-302953-gr2kk9w4 53 63 from from IN cord-302953-gr2kk9w4 53 64 Ebioscience Ebioscience NNP cord-302953-gr2kk9w4 53 65 or or CC cord-302953-gr2kk9w4 53 66 BD BD NNP cord-302953-gr2kk9w4 53 67 Pharmingen Pharmingen NNP cord-302953-gr2kk9w4 53 68 diluted dilute VBD cord-302953-gr2kk9w4 53 69 in in IN cord-302953-gr2kk9w4 53 70 BD BD NNP cord-302953-gr2kk9w4 53 71 Perm Perm NNP cord-302953-gr2kk9w4 53 72 / / SYM cord-302953-gr2kk9w4 53 73 Wash Wash NNP cord-302953-gr2kk9w4 53 74 buffer buffer NN cord-302953-gr2kk9w4 53 75 . . . cord-302953-gr2kk9w4 54 1 Cells cell NNS cord-302953-gr2kk9w4 54 2 were be VBD cord-302953-gr2kk9w4 54 3 resuspended resuspend VBN cord-302953-gr2kk9w4 54 4 in in IN cord-302953-gr2kk9w4 54 5 200 200 CD cord-302953-gr2kk9w4 54 6 µL µl XX cord-302953-gr2kk9w4 55 1 FACS FACS NNP cord-302953-gr2kk9w4 55 2 Buffer Buffer NNP cord-302953-gr2kk9w4 55 3 and and CC cord-302953-gr2kk9w4 55 4 run run VB cord-302953-gr2kk9w4 55 5 on on IN cord-302953-gr2kk9w4 55 6 a a DT cord-302953-gr2kk9w4 55 7 BD BD NNP cord-302953-gr2kk9w4 55 8 FACSCanto FACSCanto NNP cord-302953-gr2kk9w4 55 9 II II NNP cord-302953-gr2kk9w4 55 10 cytometer cytometer NN cord-302953-gr2kk9w4 55 11 using use VBG cord-302953-gr2kk9w4 55 12 BD BD NNP cord-302953-gr2kk9w4 55 13 FACSDiva facsdiva NN cord-302953-gr2kk9w4 55 14 software software NN cord-302953-gr2kk9w4 55 15 , , , cord-302953-gr2kk9w4 55 16 version version NN cord-302953-gr2kk9w4 55 17 8 8 CD cord-302953-gr2kk9w4 55 18 , , , cord-302953-gr2kk9w4 55 19 and and CC cord-302953-gr2kk9w4 55 20 analyses analysis NNS cord-302953-gr2kk9w4 55 21 were be VBD cord-302953-gr2kk9w4 55 22 carried carry VBN cord-302953-gr2kk9w4 55 23 out out RP cord-302953-gr2kk9w4 55 24 using use VBG cord-302953-gr2kk9w4 55 25 FlowJo FlowJo NNP cord-302953-gr2kk9w4 55 26 software software NN cord-302953-gr2kk9w4 55 27 , , , cord-302953-gr2kk9w4 55 28 version version NN cord-302953-gr2kk9w4 55 29 8 8 CD cord-302953-gr2kk9w4 55 30 . . . cord-302953-gr2kk9w4 56 1 Cells cell NNS cord-302953-gr2kk9w4 56 2 were be VBD cord-302953-gr2kk9w4 56 3 characterized characterize VBN cord-302953-gr2kk9w4 56 4 as as IN cord-302953-gr2kk9w4 56 5 follows follow VBZ cord-302953-gr2kk9w4 56 6 : : : cord-302953-gr2kk9w4 56 7 CD4 CD4 NNP cord-302953-gr2kk9w4 56 8 T T NNP cord-302953-gr2kk9w4 56 9 cells cell NNS cord-302953-gr2kk9w4 56 10 ( ( -LRB- cord-302953-gr2kk9w4 56 11 CD45 CD45 NNP cord-302953-gr2kk9w4 56 12 hi hi UH cord-302953-gr2kk9w4 56 13 CD3 CD3 NNP cord-302953-gr2kk9w4 56 14 + + CC cord-302953-gr2kk9w4 56 15 CD4 CD4 NNP cord-302953-gr2kk9w4 56 16 + + CC cord-302953-gr2kk9w4 56 17 ) ) -RRB- cord-302953-gr2kk9w4 56 18 , , , cord-302953-gr2kk9w4 56 19 CD8 CD8 NNP cord-302953-gr2kk9w4 56 20 T T NNP cord-302953-gr2kk9w4 56 21 cells cell NNS cord-302953-gr2kk9w4 56 22 , , , cord-302953-gr2kk9w4 56 23 and and CC cord-302953-gr2kk9w4 56 24 tissue tissue NN cord-302953-gr2kk9w4 56 25 resident resident JJ cord-302953-gr2kk9w4 56 26 memory memory NN cord-302953-gr2kk9w4 56 27 T T NNP cord-302953-gr2kk9w4 56 28 ( ( -LRB- cord-302953-gr2kk9w4 56 29 T T NNP cord-302953-gr2kk9w4 56 30 RM rm NN cord-302953-gr2kk9w4 56 31 ) ) -RRB- cord-302953-gr2kk9w4 56 32 cells cell NNS cord-302953-gr2kk9w4 56 33 ( ( -LRB- cord-302953-gr2kk9w4 56 34 CD44 CD44 NNP cord-302953-gr2kk9w4 56 35 hi hi UH cord-302953-gr2kk9w4 56 36 CD62L cd62l VB cord-302953-gr2kk9w4 56 37 − − NNP cord-302953-gr2kk9w4 56 38 CD103 CD103 NNP cord-302953-gr2kk9w4 56 39 + + CC cord-302953-gr2kk9w4 56 40 ) ) -RRB- cord-302953-gr2kk9w4 56 41 . . . cord-302953-gr2kk9w4 57 1 All all DT cord-302953-gr2kk9w4 57 2 flow flow VBP cord-302953-gr2kk9w4 57 3 cytometry cytometry NN cord-302953-gr2kk9w4 57 4 data datum NNS cord-302953-gr2kk9w4 57 5 are be VBP cord-302953-gr2kk9w4 57 6 presented present VBN cord-302953-gr2kk9w4 57 7 as as IN cord-302953-gr2kk9w4 57 8 averages average NNS cord-302953-gr2kk9w4 57 9 of of IN cord-302953-gr2kk9w4 57 10 3 3 CD cord-302953-gr2kk9w4 57 11 to to TO cord-302953-gr2kk9w4 57 12 5 5 CD cord-302953-gr2kk9w4 57 13 independent independent JJ cord-302953-gr2kk9w4 57 14 experiments experiment NNS cord-302953-gr2kk9w4 57 15 . . . cord-302953-gr2kk9w4 58 1 Following follow VBG cord-302953-gr2kk9w4 58 2 euthanasia euthanasia NN cord-302953-gr2kk9w4 58 3 , , , cord-302953-gr2kk9w4 58 4 mice mouse NNS cord-302953-gr2kk9w4 58 5 were be VBD cord-302953-gr2kk9w4 58 6 perfused perfuse VBN cord-302953-gr2kk9w4 58 7 with with IN cord-302953-gr2kk9w4 58 8 ice ice NN cord-302953-gr2kk9w4 58 9 - - HYPH cord-302953-gr2kk9w4 58 10 cold cold JJ cord-302953-gr2kk9w4 58 11 4 4 CD cord-302953-gr2kk9w4 58 12 % % NN cord-302953-gr2kk9w4 58 13 paraformaldehyde paraformaldehyde NNP cord-302953-gr2kk9w4 58 14 ( ( -LRB- cord-302953-gr2kk9w4 58 15 PFA PFA NNP cord-302953-gr2kk9w4 58 16 ) ) -RRB- cord-302953-gr2kk9w4 58 17 , , , cord-302953-gr2kk9w4 58 18 and and CC cord-302953-gr2kk9w4 58 19 brains brain NNS cord-302953-gr2kk9w4 58 20 and and CC cord-302953-gr2kk9w4 58 21 spinal spinal JJ cord-302953-gr2kk9w4 58 22 columns column NNS cord-302953-gr2kk9w4 58 23 were be VBD cord-302953-gr2kk9w4 58 24 collected collect VBN cord-302953-gr2kk9w4 58 25 . . . cord-302953-gr2kk9w4 59 1 Brains brain NNS cord-302953-gr2kk9w4 59 2 were be VBD cord-302953-gr2kk9w4 59 3 cut cut VBN cord-302953-gr2kk9w4 59 4 into into IN cord-302953-gr2kk9w4 59 5 three three CD cord-302953-gr2kk9w4 59 6 coronal coronal JJ cord-302953-gr2kk9w4 59 7 sections section NNS cord-302953-gr2kk9w4 59 8 using use VBG cord-302953-gr2kk9w4 59 9 an an DT cord-302953-gr2kk9w4 59 10 Adult Adult NNP cord-302953-gr2kk9w4 59 11 Mouse mouse NN cord-302953-gr2kk9w4 59 12 Brain Brain NNP cord-302953-gr2kk9w4 59 13 Slicer Slicer NNP cord-302953-gr2kk9w4 59 14 ( ( -LRB- cord-302953-gr2kk9w4 59 15 Zivic Zivic NNP cord-302953-gr2kk9w4 59 16 Instruments Instruments NNP cord-302953-gr2kk9w4 59 17 , , , cord-302953-gr2kk9w4 59 18 Pittsburgh Pittsburgh NNP cord-302953-gr2kk9w4 59 19 , , , cord-302953-gr2kk9w4 59 20 PA PA NNP cord-302953-gr2kk9w4 59 21 , , , cord-302953-gr2kk9w4 59 22 USA USA NNP cord-302953-gr2kk9w4 59 23 ) ) -RRB- cord-302953-gr2kk9w4 59 24 , , , cord-302953-gr2kk9w4 59 25 fixed fix VBN cord-302953-gr2kk9w4 59 26 overnight overnight RB cord-302953-gr2kk9w4 59 27 in in IN cord-302953-gr2kk9w4 59 28 4 4 CD cord-302953-gr2kk9w4 59 29 % % NN cord-302953-gr2kk9w4 59 30 PFA PFA NNP cord-302953-gr2kk9w4 59 31 , , , cord-302953-gr2kk9w4 59 32 and and CC cord-302953-gr2kk9w4 59 33 embedded embed VBN cord-302953-gr2kk9w4 59 34 in in IN cord-302953-gr2kk9w4 59 35 paraffin paraffin NN cord-302953-gr2kk9w4 59 36 . . . cord-302953-gr2kk9w4 60 1 Spinal spinal JJ cord-302953-gr2kk9w4 60 2 columns column NNS cord-302953-gr2kk9w4 60 3 were be VBD cord-302953-gr2kk9w4 60 4 fixed fix VBN cord-302953-gr2kk9w4 60 5 overnight overnight RB cord-302953-gr2kk9w4 60 6 in in IN cord-302953-gr2kk9w4 60 7 4 4 CD cord-302953-gr2kk9w4 60 8 % % NN cord-302953-gr2kk9w4 60 9 PFA PFA NNP cord-302953-gr2kk9w4 60 10 , , , cord-302953-gr2kk9w4 60 11 decalcified decalcify VBN cord-302953-gr2kk9w4 60 12 for for IN cord-302953-gr2kk9w4 60 13 36 36 CD cord-302953-gr2kk9w4 60 14 h h NN cord-302953-gr2kk9w4 60 15 in in IN cord-302953-gr2kk9w4 60 16 a a DT cord-302953-gr2kk9w4 60 17 10 10 CD cord-302953-gr2kk9w4 60 18 % % NN cord-302953-gr2kk9w4 60 19 sodium sodium NN cord-302953-gr2kk9w4 60 20 citrate/22 citrate/22 NN cord-302953-gr2kk9w4 60 21 % % NN cord-302953-gr2kk9w4 60 22 formic formic JJ cord-302953-gr2kk9w4 60 23 acid acid NN cord-302953-gr2kk9w4 60 24 solution solution NN cord-302953-gr2kk9w4 60 25 , , , cord-302953-gr2kk9w4 60 26 cut cut VBN cord-302953-gr2kk9w4 60 27 to to TO cord-302953-gr2kk9w4 60 28 isolate isolate VB cord-302953-gr2kk9w4 60 29 the the DT cord-302953-gr2kk9w4 60 30 L4-L6 L4-L6 NNP cord-302953-gr2kk9w4 60 31 spinal spinal JJ cord-302953-gr2kk9w4 60 32 cord cord NN cord-302953-gr2kk9w4 60 33 regions region NNS cord-302953-gr2kk9w4 60 34 , , , cord-302953-gr2kk9w4 60 35 and and CC cord-302953-gr2kk9w4 60 36 embedded embed VBN cord-302953-gr2kk9w4 60 37 in in IN cord-302953-gr2kk9w4 60 38 paraffin paraffin NN cord-302953-gr2kk9w4 60 39 . . . cord-302953-gr2kk9w4 61 1 Viruses virus NNS cord-302953-gr2kk9w4 61 2 2020 2020 CD cord-302953-gr2kk9w4 61 3 , , , cord-302953-gr2kk9w4 61 4 12 12 CD cord-302953-gr2kk9w4 61 5 , , , cord-302953-gr2kk9w4 61 6 113 113 CD cord-302953-gr2kk9w4 61 7 5 5 CD cord-302953-gr2kk9w4 61 8 of of IN cord-302953-gr2kk9w4 61 9 25 25 CD cord-302953-gr2kk9w4 61 10 10 10 CD cord-302953-gr2kk9w4 61 11 µm µm JJR cord-302953-gr2kk9w4 61 12 tissue tissue NN cord-302953-gr2kk9w4 61 13 sections section NNS cord-302953-gr2kk9w4 61 14 from from IN cord-302953-gr2kk9w4 61 15 3 3 CD cord-302953-gr2kk9w4 61 16 to to IN cord-302953-gr2kk9w4 61 17 4 4 CD cord-302953-gr2kk9w4 61 18 mice mouse NNS cord-302953-gr2kk9w4 61 19 per per IN cord-302953-gr2kk9w4 61 20 group group NN cord-302953-gr2kk9w4 61 21 were be VBD cord-302953-gr2kk9w4 61 22 stained stain VBN cord-302953-gr2kk9w4 61 23 with with IN cord-302953-gr2kk9w4 61 24 hematoxylin hematoxylin NNP cord-302953-gr2kk9w4 61 25 and and CC cord-302953-gr2kk9w4 61 26 eosin eosin NNP cord-302953-gr2kk9w4 61 27 ( ( -LRB- cord-302953-gr2kk9w4 61 28 H&E H&E NNP cord-302953-gr2kk9w4 61 29 ) ) -RRB- cord-302953-gr2kk9w4 61 30 . . . cord-302953-gr2kk9w4 62 1 Brain brain NN cord-302953-gr2kk9w4 62 2 slides slide NNS cord-302953-gr2kk9w4 62 3 were be VBD cord-302953-gr2kk9w4 62 4 coded code VBN cord-302953-gr2kk9w4 62 5 and and CC cord-302953-gr2kk9w4 62 6 sections section NNS cord-302953-gr2kk9w4 62 7 scored score VBD cord-302953-gr2kk9w4 62 8 as as IN cord-302953-gr2kk9w4 62 9 previously previously RB cord-302953-gr2kk9w4 62 10 described describe VBN cord-302953-gr2kk9w4 62 11 [ [ -LRB- cord-302953-gr2kk9w4 62 12 23 23 CD cord-302953-gr2kk9w4 62 13 ] ] -RRB- cord-302953-gr2kk9w4 62 14 using use VBG cord-302953-gr2kk9w4 62 15 a a DT cord-302953-gr2kk9w4 62 16 0 0 CD cord-302953-gr2kk9w4 62 17 - - HYPH cord-302953-gr2kk9w4 62 18 3(4 3(4 CD cord-302953-gr2kk9w4 62 19 ) ) -RRB- cord-302953-gr2kk9w4 62 20 scale scale NN cord-302953-gr2kk9w4 62 21 : : : cord-302953-gr2kk9w4 62 22 0 0 NFP cord-302953-gr2kk9w4 62 23 , , , cord-302953-gr2kk9w4 62 24 no no DT cord-302953-gr2kk9w4 62 25 detectable detectable JJ cord-302953-gr2kk9w4 62 26 inflammation inflammation NN cord-302953-gr2kk9w4 62 27 ; ; : cord-302953-gr2kk9w4 62 28 1 1 CD cord-302953-gr2kk9w4 62 29 , , , cord-302953-gr2kk9w4 62 30 one one CD cord-302953-gr2kk9w4 62 31 or or CC cord-302953-gr2kk9w4 62 32 two two CD cord-302953-gr2kk9w4 62 33 small small JJ cord-302953-gr2kk9w4 62 34 inflammatory inflammatory JJ cord-302953-gr2kk9w4 62 35 foci focus NNS cord-302953-gr2kk9w4 62 36 ; ; , cord-302953-gr2kk9w4 62 37 2 2 CD cord-302953-gr2kk9w4 62 38 , , , cord-302953-gr2kk9w4 62 39 moderate moderate JJ cord-302953-gr2kk9w4 62 40 inflammatory inflammatory JJ cord-302953-gr2kk9w4 62 41 foci foci NN cord-302953-gr2kk9w4 62 42 in in IN cord-302953-gr2kk9w4 62 43 up up IN cord-302953-gr2kk9w4 62 44 to to TO cord-302953-gr2kk9w4 62 45 50 50 CD cord-302953-gr2kk9w4 62 46 % % NN cord-302953-gr2kk9w4 62 47 of of IN cord-302953-gr2kk9w4 62 48 10× 10× CD cord-302953-gr2kk9w4 62 49 magnification magnification NN cord-302953-gr2kk9w4 62 50 fields field NNS cord-302953-gr2kk9w4 62 51 per per IN cord-302953-gr2kk9w4 62 52 section section NN cord-302953-gr2kk9w4 62 53 ; ; : cord-302953-gr2kk9w4 62 54 3 3 CD cord-302953-gr2kk9w4 62 55 , , , cord-302953-gr2kk9w4 62 56 moderate moderate JJ cord-302953-gr2kk9w4 62 57 to to TO cord-302953-gr2kk9w4 62 58 large large JJ cord-302953-gr2kk9w4 62 59 inflammatory inflammatory JJ cord-302953-gr2kk9w4 62 60 foci foci NN cord-302953-gr2kk9w4 62 61 in in IN cord-302953-gr2kk9w4 62 62 greater great JJR cord-302953-gr2kk9w4 62 63 than than IN cord-302953-gr2kk9w4 62 64 50 50 CD cord-302953-gr2kk9w4 62 65 % % NN cord-302953-gr2kk9w4 62 66 of of IN cord-302953-gr2kk9w4 62 67 10× 10× CD cord-302953-gr2kk9w4 62 68 magnification magnification NN cord-302953-gr2kk9w4 62 69 fields field NNS cord-302953-gr2kk9w4 62 70 . . . cord-302953-gr2kk9w4 63 1 An an DT cord-302953-gr2kk9w4 63 2 additional additional JJ cord-302953-gr2kk9w4 63 3 point point NN cord-302953-gr2kk9w4 63 4 was be VBD cord-302953-gr2kk9w4 63 5 given give VBN cord-302953-gr2kk9w4 63 6 for for IN cord-302953-gr2kk9w4 63 7 excessive excessive JJ cord-302953-gr2kk9w4 63 8 parenchymal parenchymal NN cord-302953-gr2kk9w4 63 9 cellularity cellularity NN cord-302953-gr2kk9w4 63 10 , , , cord-302953-gr2kk9w4 63 11 allowing allow VBG cord-302953-gr2kk9w4 63 12 for for IN cord-302953-gr2kk9w4 63 13 a a DT cord-302953-gr2kk9w4 63 14 maximum maximum JJ cord-302953-gr2kk9w4 63 15 score score NN cord-302953-gr2kk9w4 63 16 of of IN cord-302953-gr2kk9w4 63 17 4 4 CD cord-302953-gr2kk9w4 63 18 . . . cord-302953-gr2kk9w4 64 1 Spinal spinal JJ cord-302953-gr2kk9w4 64 2 cord cord NN cord-302953-gr2kk9w4 64 3 slides slide NNS cord-302953-gr2kk9w4 64 4 were be VBD cord-302953-gr2kk9w4 64 5 coded code VBN cord-302953-gr2kk9w4 64 6 and and CC cord-302953-gr2kk9w4 64 7 sections section NNS cord-302953-gr2kk9w4 64 8 scored score VBD cord-302953-gr2kk9w4 64 9 using use VBG cord-302953-gr2kk9w4 64 10 a a DT cord-302953-gr2kk9w4 64 11 modified modify VBN cord-302953-gr2kk9w4 64 12 0 0 CD cord-302953-gr2kk9w4 64 13 - - HYPH cord-302953-gr2kk9w4 64 14 2(3 2(3 CD cord-302953-gr2kk9w4 64 15 ) ) -RRB- cord-302953-gr2kk9w4 64 16 scale scale NN cord-302953-gr2kk9w4 64 17 as as IN cord-302953-gr2kk9w4 64 18 previously previously RB cord-302953-gr2kk9w4 64 19 described describe VBN cord-302953-gr2kk9w4 64 20 [ [ -LRB- cord-302953-gr2kk9w4 64 21 24 24 CD cord-302953-gr2kk9w4 64 22 ] ] -RRB- cord-302953-gr2kk9w4 64 23 : : : cord-302953-gr2kk9w4 64 24 0 0 NFP cord-302953-gr2kk9w4 64 25 , , , cord-302953-gr2kk9w4 64 26 no no DT cord-302953-gr2kk9w4 64 27 detectable detectable JJ cord-302953-gr2kk9w4 64 28 inflammation inflammation NN cord-302953-gr2kk9w4 64 29 ; ; : cord-302953-gr2kk9w4 64 30 1 1 CD cord-302953-gr2kk9w4 64 31 , , , cord-302953-gr2kk9w4 64 32 one one CD cord-302953-gr2kk9w4 64 33 to to TO cord-302953-gr2kk9w4 64 34 two two CD cord-302953-gr2kk9w4 64 35 small small JJ cord-302953-gr2kk9w4 64 36 inflammatory inflammatory JJ cord-302953-gr2kk9w4 64 37 foci focus NNS cord-302953-gr2kk9w4 64 38 ; ; , cord-302953-gr2kk9w4 64 39 2 2 CD cord-302953-gr2kk9w4 64 40 , , , cord-302953-gr2kk9w4 64 41 greater great JJR cord-302953-gr2kk9w4 64 42 than than IN cord-302953-gr2kk9w4 64 43 two two CD cord-302953-gr2kk9w4 64 44 inflammatory inflammatory JJ cord-302953-gr2kk9w4 64 45 foci foci NN cord-302953-gr2kk9w4 64 46 per per IN cord-302953-gr2kk9w4 64 47 spinal spinal JJ cord-302953-gr2kk9w4 64 48 cord cord NN cord-302953-gr2kk9w4 64 49 or or CC cord-302953-gr2kk9w4 64 50 moderate moderate JJ cord-302953-gr2kk9w4 64 51 to to TO cord-302953-gr2kk9w4 64 52 marked mark VBN cord-302953-gr2kk9w4 64 53 inflammatory inflammatory JJ cord-302953-gr2kk9w4 64 54 foci foci NN cord-302953-gr2kk9w4 64 55 . . . cord-302953-gr2kk9w4 65 1 An an DT cord-302953-gr2kk9w4 65 2 additional additional JJ cord-302953-gr2kk9w4 65 3 point point NN cord-302953-gr2kk9w4 65 4 was be VBD cord-302953-gr2kk9w4 65 5 given give VBN cord-302953-gr2kk9w4 65 6 for for IN cord-302953-gr2kk9w4 65 7 excessive excessive JJ cord-302953-gr2kk9w4 65 8 parenchymal parenchymal NN cord-302953-gr2kk9w4 65 9 cellularity cellularity NN cord-302953-gr2kk9w4 65 10 , , , cord-302953-gr2kk9w4 65 11 allowing allow VBG cord-302953-gr2kk9w4 65 12 for for IN cord-302953-gr2kk9w4 65 13 a a DT cord-302953-gr2kk9w4 65 14 maximum maximum JJ cord-302953-gr2kk9w4 65 15 score score NN cord-302953-gr2kk9w4 65 16 of of IN cord-302953-gr2kk9w4 65 17 3 3 CD cord-302953-gr2kk9w4 65 18 . . . cord-302953-gr2kk9w4 66 1 Statistical statistical JJ cord-302953-gr2kk9w4 66 2 analyses analysis NNS cord-302953-gr2kk9w4 66 3 were be VBD cord-302953-gr2kk9w4 66 4 performed perform VBN cord-302953-gr2kk9w4 66 5 using use VBG cord-302953-gr2kk9w4 66 6 Graphpad Graphpad NNP cord-302953-gr2kk9w4 66 7 Prism Prism NNP cord-302953-gr2kk9w4 66 8 6 6 CD cord-302953-gr2kk9w4 66 9 software software NN cord-302953-gr2kk9w4 66 10 . . . cord-302953-gr2kk9w4 67 1 Time time NN cord-302953-gr2kk9w4 67 2 - - HYPH cord-302953-gr2kk9w4 67 3 course course NN cord-302953-gr2kk9w4 67 4 studies study NNS cord-302953-gr2kk9w4 67 5 were be VBD cord-302953-gr2kk9w4 67 6 analyzed analyze VBN cord-302953-gr2kk9w4 67 7 by by IN cord-302953-gr2kk9w4 67 8 two two CD cord-302953-gr2kk9w4 67 9 - - HYPH cord-302953-gr2kk9w4 67 10 way way NN cord-302953-gr2kk9w4 67 11 ANOVA anova NN cord-302953-gr2kk9w4 67 12 with with IN cord-302953-gr2kk9w4 67 13 Bonferroni Bonferroni NNP cord-302953-gr2kk9w4 67 14 's 's POS cord-302953-gr2kk9w4 67 15 or or CC cord-302953-gr2kk9w4 67 16 Tukey Tukey NNP cord-302953-gr2kk9w4 67 17 's 's POS cord-302953-gr2kk9w4 67 18 multiple multiple JJ cord-302953-gr2kk9w4 67 19 comparison comparison NN cord-302953-gr2kk9w4 67 20 post post NN cord-302953-gr2kk9w4 67 21 - - JJ cord-302953-gr2kk9w4 67 22 test test NN cord-302953-gr2kk9w4 67 23 for for IN cord-302953-gr2kk9w4 67 24 two two CD cord-302953-gr2kk9w4 67 25 group group NN cord-302953-gr2kk9w4 67 26 and and CC cord-302953-gr2kk9w4 67 27 three three CD cord-302953-gr2kk9w4 67 28 group group NN cord-302953-gr2kk9w4 67 29 comparisons comparison NNS cord-302953-gr2kk9w4 67 30 , , , cord-302953-gr2kk9w4 67 31 respectively respectively RB cord-302953-gr2kk9w4 67 32 . . . cord-302953-gr2kk9w4 68 1 Comparisons comparison NNS cord-302953-gr2kk9w4 68 2 between between IN cord-302953-gr2kk9w4 68 3 three three CD cord-302953-gr2kk9w4 68 4 groups group NNS cord-302953-gr2kk9w4 68 5 at at IN cord-302953-gr2kk9w4 68 6 a a DT cord-302953-gr2kk9w4 68 7 single single JJ cord-302953-gr2kk9w4 68 8 time time NN cord-302953-gr2kk9w4 68 9 point point NN cord-302953-gr2kk9w4 68 10 were be VBD cord-302953-gr2kk9w4 68 11 made make VBN cord-302953-gr2kk9w4 68 12 using use VBG cord-302953-gr2kk9w4 68 13 one one CD cord-302953-gr2kk9w4 68 14 - - HYPH cord-302953-gr2kk9w4 68 15 way way NN cord-302953-gr2kk9w4 68 16 ANOVA anova NN cord-302953-gr2kk9w4 68 17 with with IN cord-302953-gr2kk9w4 68 18 Tukey Tukey NNP cord-302953-gr2kk9w4 68 19 's 's POS cord-302953-gr2kk9w4 68 20 multiple multiple JJ cord-302953-gr2kk9w4 68 21 comparisons comparison NNS cord-302953-gr2kk9w4 68 22 post post VBP cord-302953-gr2kk9w4 68 23 - - JJ cord-302953-gr2kk9w4 68 24 test test NN cord-302953-gr2kk9w4 68 25 . . . cord-302953-gr2kk9w4 69 1 A a DT cord-302953-gr2kk9w4 69 2 p p NN cord-302953-gr2kk9w4 69 3 value value NN cord-302953-gr2kk9w4 69 4 of of IN cord-302953-gr2kk9w4 69 5 < < NNP cord-302953-gr2kk9w4 69 6 0.05 0.05 CD cord-302953-gr2kk9w4 69 7 was be VBD cord-302953-gr2kk9w4 69 8 considered consider VBN cord-302953-gr2kk9w4 69 9 significant significant JJ cord-302953-gr2kk9w4 69 10 for for IN cord-302953-gr2kk9w4 69 11 all all DT cord-302953-gr2kk9w4 69 12 analyses analysis NNS cord-302953-gr2kk9w4 69 13 . . . cord-302953-gr2kk9w4 70 1 To to TO cord-302953-gr2kk9w4 70 2 elucidate elucidate VB cord-302953-gr2kk9w4 70 3 a a DT cord-302953-gr2kk9w4 70 4 potential potential JJ cord-302953-gr2kk9w4 70 5 role role NN cord-302953-gr2kk9w4 70 6 for for IN cord-302953-gr2kk9w4 70 7 IFN IFN NNP cord-302953-gr2kk9w4 70 8 - - HYPH cord-302953-gr2kk9w4 70 9 γ γ NNP cord-302953-gr2kk9w4 70 10 in in IN cord-302953-gr2kk9w4 70 11 virus virus NN cord-302953-gr2kk9w4 70 12 clearance clearance NN cord-302953-gr2kk9w4 70 13 from from IN cord-302953-gr2kk9w4 70 14 neurons neuron NNS cord-302953-gr2kk9w4 70 15 , , , cord-302953-gr2kk9w4 70 16 immature immature JJ cord-302953-gr2kk9w4 70 17 cycling cycling NN cord-302953-gr2kk9w4 70 18 cAP-7 cAP-7 NNP cord-302953-gr2kk9w4 70 19 olfactory olfactory JJ cord-302953-gr2kk9w4 70 20 neuronal neuronal JJ cord-302953-gr2kk9w4 70 21 cells cell NNS cord-302953-gr2kk9w4 70 22 and and CC cord-302953-gr2kk9w4 70 23 mature mature VB cord-302953-gr2kk9w4 70 24 bipolar bipolar JJ cord-302953-gr2kk9w4 70 25 differentiated differentiate VBN cord-302953-gr2kk9w4 70 26 dAP-7 dap-7 NN cord-302953-gr2kk9w4 70 27 cells cell NNS cord-302953-gr2kk9w4 70 28 [ [ -LRB- cord-302953-gr2kk9w4 70 29 19 19 CD cord-302953-gr2kk9w4 70 30 ] ] -RRB- cord-302953-gr2kk9w4 70 31 were be VBD cord-302953-gr2kk9w4 70 32 infected infect VBN cord-302953-gr2kk9w4 70 33 with with IN cord-302953-gr2kk9w4 70 34 SINV SINV NNP cord-302953-gr2kk9w4 70 35 ( ( -LRB- cord-302953-gr2kk9w4 70 36 MOI MOI NNP cord-302953-gr2kk9w4 70 37 = = SYM cord-302953-gr2kk9w4 70 38 5 5 CD cord-302953-gr2kk9w4 70 39 ) ) -RRB- cord-302953-gr2kk9w4 70 40 . . . cord-302953-gr2kk9w4 71 1 Both both DT cord-302953-gr2kk9w4 71 2 cAP-7 cap-7 XX cord-302953-gr2kk9w4 71 3 and and CC cord-302953-gr2kk9w4 71 4 dAP-7 dap-7 JJ cord-302953-gr2kk9w4 71 5 cells cell NNS cord-302953-gr2kk9w4 71 6 supported support VBD cord-302953-gr2kk9w4 71 7 virus virus NN cord-302953-gr2kk9w4 71 8 replication replication NN cord-302953-gr2kk9w4 71 9 , , , cord-302953-gr2kk9w4 71 10 with with IN cord-302953-gr2kk9w4 71 11 cAP-7 cAP-7 NNP cord-302953-gr2kk9w4 71 12 cells cell NNS cord-302953-gr2kk9w4 71 13 producing produce VBG cord-302953-gr2kk9w4 71 14 higher high JJR cord-302953-gr2kk9w4 71 15 peak peak NN cord-302953-gr2kk9w4 71 16 titers titer NNS cord-302953-gr2kk9w4 71 17 than than IN cord-302953-gr2kk9w4 71 18 dAP-7 dap-7 JJ cord-302953-gr2kk9w4 71 19 cells cell NNS cord-302953-gr2kk9w4 71 20 and and CC cord-302953-gr2kk9w4 71 21 dying die VBG cord-302953-gr2kk9w4 71 22 by by IN cord-302953-gr2kk9w4 71 23 48 48 CD cord-302953-gr2kk9w4 71 24 HPI HPI NNP cord-302953-gr2kk9w4 71 25 ( ( -LRB- cord-302953-gr2kk9w4 71 26 Figure Figure NNP cord-302953-gr2kk9w4 71 27 1A 1a NN cord-302953-gr2kk9w4 71 28 ) ) -RRB- cord-302953-gr2kk9w4 71 29 . . . cord-302953-gr2kk9w4 72 1 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 72 2 cells cell NNS cord-302953-gr2kk9w4 72 3 continued continue VBD cord-302953-gr2kk9w4 72 4 to to TO cord-302953-gr2kk9w4 72 5 produce produce VB cord-302953-gr2kk9w4 72 6 virus virus NN cord-302953-gr2kk9w4 72 7 through through IN cord-302953-gr2kk9w4 72 8 72 72 CD cord-302953-gr2kk9w4 72 9 HPI HPI NNP cord-302953-gr2kk9w4 72 10 and and CC cord-302953-gr2kk9w4 72 11 were be VBD cord-302953-gr2kk9w4 72 12 used use VBN cord-302953-gr2kk9w4 72 13 for for IN cord-302953-gr2kk9w4 72 14 subsequent subsequent JJ cord-302953-gr2kk9w4 72 15 studies study NNS cord-302953-gr2kk9w4 72 16 of of IN cord-302953-gr2kk9w4 72 17 the the DT cord-302953-gr2kk9w4 72 18 effect effect NN cord-302953-gr2kk9w4 72 19 of of IN cord-302953-gr2kk9w4 72 20 IFN IFN NNP cord-302953-gr2kk9w4 72 21 - - HYPH cord-302953-gr2kk9w4 72 22 γ γ NNP cord-302953-gr2kk9w4 72 23 on on IN cord-302953-gr2kk9w4 72 24 virus virus NN cord-302953-gr2kk9w4 72 25 replication replication NN cord-302953-gr2kk9w4 72 26 . . . cord-302953-gr2kk9w4 73 1 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 73 2 cells cell NNS cord-302953-gr2kk9w4 73 3 infected infect VBN cord-302953-gr2kk9w4 73 4 with with IN cord-302953-gr2kk9w4 73 5 SINV SINV NNP cord-302953-gr2kk9w4 74 1 ( ( -LRB- cord-302953-gr2kk9w4 74 2 MOI MOI NNP cord-302953-gr2kk9w4 74 3 = = SYM cord-302953-gr2kk9w4 74 4 1 1 CD cord-302953-gr2kk9w4 74 5 ) ) -RRB- cord-302953-gr2kk9w4 74 6 were be VBD cord-302953-gr2kk9w4 74 7 treated treat VBN cord-302953-gr2kk9w4 74 8 with with IN cord-302953-gr2kk9w4 74 9 500 500 CD cord-302953-gr2kk9w4 74 10 U u NN cord-302953-gr2kk9w4 74 11 / / SYM cord-302953-gr2kk9w4 74 12 mL ml NN cord-302953-gr2kk9w4 74 13 rat rat NN cord-302953-gr2kk9w4 74 14 recombinant recombinant NN cord-302953-gr2kk9w4 74 15 IFN IFN NNP cord-302953-gr2kk9w4 74 16 - - HYPH cord-302953-gr2kk9w4 74 17 γ γ NNP cord-302953-gr2kk9w4 74 18 2 2 CD cord-302953-gr2kk9w4 74 19 h h NN cord-302953-gr2kk9w4 74 20 before before IN cord-302953-gr2kk9w4 74 21 infection infection NN cord-302953-gr2kk9w4 74 22 , , , cord-302953-gr2kk9w4 74 23 2 2 CD cord-302953-gr2kk9w4 74 24 HPI HPI NNP cord-302953-gr2kk9w4 74 25 , , , cord-302953-gr2kk9w4 74 26 or or CC cord-302953-gr2kk9w4 74 27 at at IN cord-302953-gr2kk9w4 74 28 24 24 CD cord-302953-gr2kk9w4 74 29 HPI HPI NNP cord-302953-gr2kk9w4 74 30 . . . cord-302953-gr2kk9w4 75 1 Virus virus NN cord-302953-gr2kk9w4 75 2 replicated replicate VBD cord-302953-gr2kk9w4 75 3 in in IN cord-302953-gr2kk9w4 75 4 all all DT cord-302953-gr2kk9w4 75 5 treatment treatment NN cord-302953-gr2kk9w4 75 6 groups group NNS cord-302953-gr2kk9w4 75 7 , , , cord-302953-gr2kk9w4 75 8 with with IN cord-302953-gr2kk9w4 75 9 titers titer NNS cord-302953-gr2kk9w4 75 10 peaking peak VBG cord-302953-gr2kk9w4 75 11 at at IN cord-302953-gr2kk9w4 75 12 about about RB cord-302953-gr2kk9w4 75 13 32 32 CD cord-302953-gr2kk9w4 75 14 HPI HPI NNP cord-302953-gr2kk9w4 75 15 ( ( -LRB- cord-302953-gr2kk9w4 75 16 Figure figure NN cord-302953-gr2kk9w4 75 17 1B 1b CD cord-302953-gr2kk9w4 75 18 ) ) -RRB- cord-302953-gr2kk9w4 75 19 . . . cord-302953-gr2kk9w4 76 1 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 76 2 cells cell NNS cord-302953-gr2kk9w4 76 3 treated treat VBN cord-302953-gr2kk9w4 76 4 with with IN cord-302953-gr2kk9w4 76 5 IFN IFN NNP cord-302953-gr2kk9w4 76 6 - - HYPH cord-302953-gr2kk9w4 76 7 γ γ NNP cord-302953-gr2kk9w4 76 8 prior prior RB cord-302953-gr2kk9w4 76 9 to to IN cord-302953-gr2kk9w4 76 10 infection infection NN cord-302953-gr2kk9w4 76 11 and and CC cord-302953-gr2kk9w4 76 12 at at IN cord-302953-gr2kk9w4 76 13 2 2 CD cord-302953-gr2kk9w4 76 14 HPI HPI NNP cord-302953-gr2kk9w4 76 15 had have VBD cord-302953-gr2kk9w4 76 16 significantly significantly RB cord-302953-gr2kk9w4 76 17 decreased decrease VBN cord-302953-gr2kk9w4 76 18 virus virus NN cord-302953-gr2kk9w4 76 19 production production NN cord-302953-gr2kk9w4 76 20 compared compare VBN cord-302953-gr2kk9w4 76 21 to to IN cord-302953-gr2kk9w4 76 22 untreated untreated JJ cord-302953-gr2kk9w4 76 23 cells cell NNS cord-302953-gr2kk9w4 76 24 at at IN cord-302953-gr2kk9w4 76 25 24 24 CD cord-302953-gr2kk9w4 76 26 , , , cord-302953-gr2kk9w4 76 27 32 32 CD cord-302953-gr2kk9w4 76 28 , , , cord-302953-gr2kk9w4 76 29 and and CC cord-302953-gr2kk9w4 76 30 48 48 CD cord-302953-gr2kk9w4 76 31 HPI HPI NNP cord-302953-gr2kk9w4 76 32 , , , cord-302953-gr2kk9w4 76 33 with with IN cord-302953-gr2kk9w4 76 34 the the DT cord-302953-gr2kk9w4 76 35 greatest great JJS cord-302953-gr2kk9w4 76 36 effect effect NN cord-302953-gr2kk9w4 76 37 seen see VBN cord-302953-gr2kk9w4 76 38 in in IN cord-302953-gr2kk9w4 76 39 pretreated pretreated JJ cord-302953-gr2kk9w4 76 40 cells cell NNS cord-302953-gr2kk9w4 76 41 , , , cord-302953-gr2kk9w4 76 42 demonstrating demonstrate VBG cord-302953-gr2kk9w4 76 43 the the DT cord-302953-gr2kk9w4 76 44 ability ability NN cord-302953-gr2kk9w4 76 45 of of IN cord-302953-gr2kk9w4 76 46 neurons neuron NNS cord-302953-gr2kk9w4 76 47 to to TO cord-302953-gr2kk9w4 76 48 develop develop VB cord-302953-gr2kk9w4 76 49 an an DT cord-302953-gr2kk9w4 76 50 IFN IFN NNP cord-302953-gr2kk9w4 76 51 - - HYPH cord-302953-gr2kk9w4 76 52 γ γ NN cord-302953-gr2kk9w4 76 53 - - HYPH cord-302953-gr2kk9w4 76 54 induced induce VBN cord-302953-gr2kk9w4 76 55 antiviral antiviral JJ cord-302953-gr2kk9w4 76 56 response response NN cord-302953-gr2kk9w4 76 57 . . . cord-302953-gr2kk9w4 77 1 Treatment treatment NN cord-302953-gr2kk9w4 77 2 with with IN cord-302953-gr2kk9w4 77 3 IFN IFN NNP cord-302953-gr2kk9w4 77 4 - - HYPH cord-302953-gr2kk9w4 77 5 γ γ NNP cord-302953-gr2kk9w4 77 6 at at IN cord-302953-gr2kk9w4 77 7 24 24 CD cord-302953-gr2kk9w4 77 8 HPI HPI NNP cord-302953-gr2kk9w4 77 9 did do VBD cord-302953-gr2kk9w4 77 10 not not RB cord-302953-gr2kk9w4 77 11 alter alter VB cord-302953-gr2kk9w4 77 12 virus virus NN cord-302953-gr2kk9w4 77 13 production production NN cord-302953-gr2kk9w4 77 14 . . . cord-302953-gr2kk9w4 78 1 To to TO cord-302953-gr2kk9w4 78 2 assess assess VB cord-302953-gr2kk9w4 78 3 the the DT cord-302953-gr2kk9w4 78 4 effect effect NN cord-302953-gr2kk9w4 78 5 of of IN cord-302953-gr2kk9w4 78 6 IFN IFN NNP cord-302953-gr2kk9w4 78 7 - - HYPH cord-302953-gr2kk9w4 78 8 γ γ NNP cord-302953-gr2kk9w4 78 9 on on IN cord-302953-gr2kk9w4 78 10 virus virus NN cord-302953-gr2kk9w4 78 11 replication replication NN cord-302953-gr2kk9w4 78 12 after after IN cord-302953-gr2kk9w4 78 13 infection infection NN cord-302953-gr2kk9w4 78 14 was be VBD cord-302953-gr2kk9w4 78 15 established establish VBN cord-302953-gr2kk9w4 78 16 , , , cord-302953-gr2kk9w4 78 17 production production NN cord-302953-gr2kk9w4 78 18 of of IN cord-302953-gr2kk9w4 78 19 SINV SINV NNP cord-302953-gr2kk9w4 78 20 proteins protein NNS cord-302953-gr2kk9w4 78 21 was be VBD cord-302953-gr2kk9w4 78 22 examined examine VBN cord-302953-gr2kk9w4 78 23 by by IN cord-302953-gr2kk9w4 78 24 immunoblot immunoblot NNP cord-302953-gr2kk9w4 78 25 in in IN cord-302953-gr2kk9w4 78 26 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 78 27 cells cell NNS cord-302953-gr2kk9w4 78 28 infected infect VBN cord-302953-gr2kk9w4 78 29 with with IN cord-302953-gr2kk9w4 78 30 SINV SINV NNP cord-302953-gr2kk9w4 78 31 alone alone JJ cord-302953-gr2kk9w4 78 32 or or CC cord-302953-gr2kk9w4 78 33 treated treat VBN cord-302953-gr2kk9w4 78 34 with with IN cord-302953-gr2kk9w4 78 35 IFN IFN NNP cord-302953-gr2kk9w4 78 36 - - HYPH cord-302953-gr2kk9w4 78 37 γ γ NNP cord-302953-gr2kk9w4 78 38 at at IN cord-302953-gr2kk9w4 78 39 2 2 CD cord-302953-gr2kk9w4 78 40 HPI HPI NNP cord-302953-gr2kk9w4 78 41 . . . cord-302953-gr2kk9w4 79 1 In in IN cord-302953-gr2kk9w4 79 2 untreated untreated JJ cord-302953-gr2kk9w4 79 3 SINV sinv NN cord-302953-gr2kk9w4 79 4 - - HYPH cord-302953-gr2kk9w4 79 5 infected infect VBN cord-302953-gr2kk9w4 79 6 cells cell NNS cord-302953-gr2kk9w4 79 7 , , , cord-302953-gr2kk9w4 79 8 production production NN cord-302953-gr2kk9w4 79 9 of of IN cord-302953-gr2kk9w4 79 10 the the DT cord-302953-gr2kk9w4 79 11 nonstructural nonstructural JJ cord-302953-gr2kk9w4 79 12 nsp3 nsp3 NNS cord-302953-gr2kk9w4 79 13 protein protein NN cord-302953-gr2kk9w4 79 14 and and CC cord-302953-gr2kk9w4 79 15 structural structural JJ cord-302953-gr2kk9w4 79 16 capsid capsid NN cord-302953-gr2kk9w4 79 17 protein protein NN cord-302953-gr2kk9w4 79 18 reached reach VBD cord-302953-gr2kk9w4 79 19 high high JJ cord-302953-gr2kk9w4 79 20 levels level NNS cord-302953-gr2kk9w4 79 21 by by IN cord-302953-gr2kk9w4 79 22 24 24 CD cord-302953-gr2kk9w4 79 23 HPI HPI NNP cord-302953-gr2kk9w4 79 24 ( ( -LRB- cord-302953-gr2kk9w4 79 25 Figure figure NN cord-302953-gr2kk9w4 79 26 1C 1c NN cord-302953-gr2kk9w4 79 27 ) ) -RRB- cord-302953-gr2kk9w4 79 28 . . . cord-302953-gr2kk9w4 80 1 Production production NN cord-302953-gr2kk9w4 80 2 of of IN cord-302953-gr2kk9w4 80 3 the the DT cord-302953-gr2kk9w4 80 4 E1 E1 NNP cord-302953-gr2kk9w4 80 5 and and CC cord-302953-gr2kk9w4 80 6 E2 E2 NNP cord-302953-gr2kk9w4 80 7 structural structural JJ cord-302953-gr2kk9w4 80 8 glycoproteins glycoprotein NNS cord-302953-gr2kk9w4 80 9 ( ( -LRB- cord-302953-gr2kk9w4 80 10 along along IN cord-302953-gr2kk9w4 80 11 with with IN cord-302953-gr2kk9w4 80 12 precursor precursor NN cord-302953-gr2kk9w4 80 13 to to IN cord-302953-gr2kk9w4 80 14 E2 E2 NNP cord-302953-gr2kk9w4 80 15 , , , cord-302953-gr2kk9w4 80 16 pE2 pE2 NNP cord-302953-gr2kk9w4 80 17 ) ) -RRB- cord-302953-gr2kk9w4 80 18 was be VBD cord-302953-gr2kk9w4 80 19 evident evident JJ cord-302953-gr2kk9w4 80 20 by by IN cord-302953-gr2kk9w4 80 21 48 48 CD cord-302953-gr2kk9w4 80 22 HPI HPI NNP cord-302953-gr2kk9w4 80 23 and and CC cord-302953-gr2kk9w4 80 24 diminished diminish VBN cord-302953-gr2kk9w4 80 25 by by IN cord-302953-gr2kk9w4 80 26 treatment treatment NN cord-302953-gr2kk9w4 80 27 with with IN cord-302953-gr2kk9w4 80 28 IFN IFN NNP cord-302953-gr2kk9w4 80 29 - - HYPH cord-302953-gr2kk9w4 80 30 γ γ NNP cord-302953-gr2kk9w4 80 31 . . . cord-302953-gr2kk9w4 81 1 These these DT cord-302953-gr2kk9w4 81 2 results result NNS cord-302953-gr2kk9w4 81 3 show show VBP cord-302953-gr2kk9w4 81 4 that that IN cord-302953-gr2kk9w4 81 5 IFN IFN NNP cord-302953-gr2kk9w4 81 6 - - HYPH cord-302953-gr2kk9w4 81 7 γ γ NNP cord-302953-gr2kk9w4 81 8 can can MD cord-302953-gr2kk9w4 81 9 decrease decrease VB cord-302953-gr2kk9w4 81 10 the the DT cord-302953-gr2kk9w4 81 11 production production NN cord-302953-gr2kk9w4 81 12 of of IN cord-302953-gr2kk9w4 81 13 SINV SINV NNP cord-302953-gr2kk9w4 81 14 by by IN cord-302953-gr2kk9w4 81 15 neurons neuron NNS cord-302953-gr2kk9w4 81 16 . . . cord-302953-gr2kk9w4 82 1 We -PRON- PRP cord-302953-gr2kk9w4 82 2 next next RB cord-302953-gr2kk9w4 82 3 sought seek VBD cord-302953-gr2kk9w4 82 4 to to TO cord-302953-gr2kk9w4 82 5 determine determine VB cord-302953-gr2kk9w4 82 6 the the DT cord-302953-gr2kk9w4 82 7 effects effect NNS cord-302953-gr2kk9w4 82 8 of of IN cord-302953-gr2kk9w4 82 9 IFN IFN NNP cord-302953-gr2kk9w4 82 10 - - HYPH cord-302953-gr2kk9w4 82 11 γ γ NN cord-302953-gr2kk9w4 82 12 on on IN cord-302953-gr2kk9w4 82 13 production production NN cord-302953-gr2kk9w4 82 14 of of IN cord-302953-gr2kk9w4 82 15 viral viral JJ cord-302953-gr2kk9w4 82 16 RNA RNA NNP cord-302953-gr2kk9w4 82 17 . . . cord-302953-gr2kk9w4 83 1 SINV SINV NNP cord-302953-gr2kk9w4 83 2 - - HYPH cord-302953-gr2kk9w4 83 3 infected infect VBN cord-302953-gr2kk9w4 83 4 dAP-7 dap-7 NN cord-302953-gr2kk9w4 83 5 cells cell NNS cord-302953-gr2kk9w4 83 6 were be VBD cord-302953-gr2kk9w4 83 7 treated treat VBN cord-302953-gr2kk9w4 83 8 with with IN cord-302953-gr2kk9w4 83 9 IFN IFN NNP cord-302953-gr2kk9w4 83 10 - - HYPH cord-302953-gr2kk9w4 83 11 γ γ NNP cord-302953-gr2kk9w4 83 12 at at IN cord-302953-gr2kk9w4 83 13 2 2 CD cord-302953-gr2kk9w4 83 14 HPI HPI NNP cord-302953-gr2kk9w4 83 15 , , , cord-302953-gr2kk9w4 83 16 and and CC cord-302953-gr2kk9w4 83 17 cell cell NN cord-302953-gr2kk9w4 83 18 pellets pellet NNS cord-302953-gr2kk9w4 83 19 collected collect VBN cord-302953-gr2kk9w4 83 20 to to TO cord-302953-gr2kk9w4 83 21 quantify quantify VB cord-302953-gr2kk9w4 83 22 viral viral JJ cord-302953-gr2kk9w4 83 23 RNA RNA NNP cord-302953-gr2kk9w4 83 24 by by IN cord-302953-gr2kk9w4 83 25 qRT qRT NNP cord-302953-gr2kk9w4 83 26 - - HYPH cord-302953-gr2kk9w4 83 27 PCR PCR NNP cord-302953-gr2kk9w4 83 28 . . . cord-302953-gr2kk9w4 84 1 Viral Viral NNP cord-302953-gr2kk9w4 84 2 RNA RNA NNP cord-302953-gr2kk9w4 84 3 copies copy NNS cord-302953-gr2kk9w4 84 4 were be VBD cord-302953-gr2kk9w4 84 5 comparable comparable JJ cord-302953-gr2kk9w4 84 6 at at IN cord-302953-gr2kk9w4 84 7 8 8 CD cord-302953-gr2kk9w4 84 8 HPI HPI NNP cord-302953-gr2kk9w4 84 9 . . . cord-302953-gr2kk9w4 85 1 Copy copy JJ cord-302953-gr2kk9w4 85 2 number number NN cord-302953-gr2kk9w4 85 3 in in IN cord-302953-gr2kk9w4 85 4 untreated untreated JJ cord-302953-gr2kk9w4 85 5 cells cell NNS cord-302953-gr2kk9w4 85 6 continued continue VBD cord-302953-gr2kk9w4 85 7 to to TO cord-302953-gr2kk9w4 85 8 rise rise VB cord-302953-gr2kk9w4 85 9 , , , cord-302953-gr2kk9w4 85 10 peaking peak VBG cord-302953-gr2kk9w4 85 11 at at IN cord-302953-gr2kk9w4 85 12 72 72 CD cord-302953-gr2kk9w4 85 13 HPI HPI NNP cord-302953-gr2kk9w4 85 14 , , , cord-302953-gr2kk9w4 85 15 while while IN cord-302953-gr2kk9w4 85 16 SINV SINV NNP cord-302953-gr2kk9w4 85 17 RNA RNA NNP cord-302953-gr2kk9w4 85 18 levels level NNS cord-302953-gr2kk9w4 85 19 plateaued plateaue VBD cord-302953-gr2kk9w4 85 20 in in IN cord-302953-gr2kk9w4 85 21 treated treat VBN cord-302953-gr2kk9w4 85 22 cells cell NNS cord-302953-gr2kk9w4 85 23 and and CC cord-302953-gr2kk9w4 85 24 by by IN cord-302953-gr2kk9w4 85 25 72 72 CD cord-302953-gr2kk9w4 85 26 HPI HPI NNP cord-302953-gr2kk9w4 85 27 had have VBD cord-302953-gr2kk9w4 85 28 begun begin VBN cord-302953-gr2kk9w4 85 29 to to TO cord-302953-gr2kk9w4 85 30 decrease decrease VB cord-302953-gr2kk9w4 85 31 ( ( -LRB- cord-302953-gr2kk9w4 85 32 Figure figure NN cord-302953-gr2kk9w4 85 33 1D 1d CD cord-302953-gr2kk9w4 85 34 ) ) -RRB- cord-302953-gr2kk9w4 85 35 . . . cord-302953-gr2kk9w4 86 1 Overall overall RB cord-302953-gr2kk9w4 86 2 , , , cord-302953-gr2kk9w4 86 3 viral viral JJ cord-302953-gr2kk9w4 86 4 RNA RNA NNP cord-302953-gr2kk9w4 86 5 synthesis synthesis NN cord-302953-gr2kk9w4 86 6 was be VBD cord-302953-gr2kk9w4 86 7 significantly significantly RB cord-302953-gr2kk9w4 86 8 inhibited inhibit VBN cord-302953-gr2kk9w4 86 9 by by IN cord-302953-gr2kk9w4 86 10 IFN IFN NNP cord-302953-gr2kk9w4 86 11 - - HYPH cord-302953-gr2kk9w4 86 12 γ γ NN cord-302953-gr2kk9w4 86 13 treatment treatment NN cord-302953-gr2kk9w4 86 14 compared compare VBN cord-302953-gr2kk9w4 86 15 to to IN cord-302953-gr2kk9w4 86 16 untreated untreated JJ cord-302953-gr2kk9w4 86 17 dAP-7 dap-7 NN cord-302953-gr2kk9w4 86 18 cells cell NNS cord-302953-gr2kk9w4 86 19 from from IN cord-302953-gr2kk9w4 86 20 24 24 CD cord-302953-gr2kk9w4 86 21 to to IN cord-302953-gr2kk9w4 86 22 72 72 CD cord-302953-gr2kk9w4 86 23 HPI HPI NNP cord-302953-gr2kk9w4 86 24 . . . cord-302953-gr2kk9w4 87 1 These these DT cord-302953-gr2kk9w4 87 2 studies study NNS cord-302953-gr2kk9w4 87 3 show show VBP cord-302953-gr2kk9w4 87 4 that that IN cord-302953-gr2kk9w4 87 5 IFN IFN NNP cord-302953-gr2kk9w4 87 6 - - HYPH cord-302953-gr2kk9w4 87 7 γ γ NNP cord-302953-gr2kk9w4 87 8 signaling signaling NN cord-302953-gr2kk9w4 87 9 affects affect VBZ cord-302953-gr2kk9w4 87 10 production production NN cord-302953-gr2kk9w4 87 11 and and CC cord-302953-gr2kk9w4 87 12 clearance clearance NN cord-302953-gr2kk9w4 87 13 of of IN cord-302953-gr2kk9w4 87 14 both both CC cord-302953-gr2kk9w4 87 15 infectious infectious JJ cord-302953-gr2kk9w4 87 16 virus virus NN cord-302953-gr2kk9w4 87 17 and and CC cord-302953-gr2kk9w4 87 18 viral viral JJ cord-302953-gr2kk9w4 87 19 RNA RNA NNP cord-302953-gr2kk9w4 87 20 from from IN cord-302953-gr2kk9w4 87 21 neurons neuron NNS cord-302953-gr2kk9w4 87 22 in in IN cord-302953-gr2kk9w4 87 23 vitro vitro FW cord-302953-gr2kk9w4 87 24 . . . cord-302953-gr2kk9w4 87 25 _SP cord-302953-gr2kk9w4 88 1 Because because IN cord-302953-gr2kk9w4 88 2 IFN IFN NNP cord-302953-gr2kk9w4 88 3 - - HYPH cord-302953-gr2kk9w4 88 4 γ γ NNP cord-302953-gr2kk9w4 88 5 facilitates facilitate VBZ cord-302953-gr2kk9w4 88 6 virus virus NN cord-302953-gr2kk9w4 88 7 clearance clearance NN cord-302953-gr2kk9w4 88 8 from from IN cord-302953-gr2kk9w4 88 9 neurons neuron NNS cord-302953-gr2kk9w4 88 10 , , , cord-302953-gr2kk9w4 88 11 we -PRON- PRP cord-302953-gr2kk9w4 88 12 examined examine VBD cord-302953-gr2kk9w4 88 13 induction induction NN cord-302953-gr2kk9w4 88 14 of of IN cord-302953-gr2kk9w4 88 15 antiviral antiviral JJ cord-302953-gr2kk9w4 88 16 genes gene NNS cord-302953-gr2kk9w4 88 17 by by IN cord-302953-gr2kk9w4 88 18 IFN IFN NNP cord-302953-gr2kk9w4 88 19 - - HYPH cord-302953-gr2kk9w4 88 20 γ γ NNP cord-302953-gr2kk9w4 88 21 . . . cord-302953-gr2kk9w4 89 1 mRNA mRNA NNP cord-302953-gr2kk9w4 89 2 expression expression NN cord-302953-gr2kk9w4 89 3 of of IN cord-302953-gr2kk9w4 89 4 representative representative JJ cord-302953-gr2kk9w4 89 5 antiviral antiviral JJ cord-302953-gr2kk9w4 89 6 ISGs ISGs NNPS cord-302953-gr2kk9w4 89 7 was be VBD cord-302953-gr2kk9w4 89 8 examined examine VBN cord-302953-gr2kk9w4 89 9 by by IN cord-302953-gr2kk9w4 89 10 qRT qRT NNP cord-302953-gr2kk9w4 89 11 - - HYPH cord-302953-gr2kk9w4 89 12 PCR PCR NNP cord-302953-gr2kk9w4 89 13 in in IN cord-302953-gr2kk9w4 89 14 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 89 15 cells cell NNS cord-302953-gr2kk9w4 89 16 infected infect VBN cord-302953-gr2kk9w4 89 17 with with IN cord-302953-gr2kk9w4 89 18 SINV SINV NNP cord-302953-gr2kk9w4 89 19 ( ( -LRB- cord-302953-gr2kk9w4 89 20 MOI MOI NNP cord-302953-gr2kk9w4 89 21 = = SYM cord-302953-gr2kk9w4 89 22 1 1 CD cord-302953-gr2kk9w4 89 23 ) ) -RRB- cord-302953-gr2kk9w4 89 24 and and CC cord-302953-gr2kk9w4 89 25 treated treat VBN cord-302953-gr2kk9w4 89 26 with with IN cord-302953-gr2kk9w4 89 27 500 500 CD cord-302953-gr2kk9w4 89 28 U u NN cord-302953-gr2kk9w4 89 29 / / SYM cord-302953-gr2kk9w4 89 30 mL ml NN cord-302953-gr2kk9w4 89 31 IFN IFN NNP cord-302953-gr2kk9w4 89 32 - - HYPH cord-302953-gr2kk9w4 89 33 γ γ NN cord-302953-gr2kk9w4 89 34 at at IN cord-302953-gr2kk9w4 89 35 2 2 CD cord-302953-gr2kk9w4 89 36 HPI HPI NNP cord-302953-gr2kk9w4 89 37 . . . cord-302953-gr2kk9w4 90 1 Gbp2 gbp2 NN cord-302953-gr2kk9w4 91 1 ( ( -LRB- cord-302953-gr2kk9w4 91 2 Figure figure NN cord-302953-gr2kk9w4 91 3 _SP cord-302953-gr2kk9w4 91 4 2A 2a CD cord-302953-gr2kk9w4 91 5 ) ) -RRB- cord-302953-gr2kk9w4 91 6 and and CC cord-302953-gr2kk9w4 92 1 Irgm Irgm NNP cord-302953-gr2kk9w4 92 2 ( ( -LRB- cord-302953-gr2kk9w4 92 3 Figure Figure NNP cord-302953-gr2kk9w4 92 4 2B 2b CD cord-302953-gr2kk9w4 92 5 ) ) -RRB- cord-302953-gr2kk9w4 92 6 , , , cord-302953-gr2kk9w4 92 7 two two CD cord-302953-gr2kk9w4 92 8 genes gene NNS cord-302953-gr2kk9w4 92 9 associated associate VBN cord-302953-gr2kk9w4 92 10 with with IN cord-302953-gr2kk9w4 92 11 autophagy autophagy NN cord-302953-gr2kk9w4 92 12 [ [ -LRB- cord-302953-gr2kk9w4 92 13 25 25 CD cord-302953-gr2kk9w4 92 14 ] ] -RRB- cord-302953-gr2kk9w4 92 15 , , , cord-302953-gr2kk9w4 92 16 were be VBD cord-302953-gr2kk9w4 92 17 highly highly RB cord-302953-gr2kk9w4 92 18 expressed express VBN cord-302953-gr2kk9w4 92 19 by by IN cord-302953-gr2kk9w4 92 20 SINVinfected SINVinfected NNP cord-302953-gr2kk9w4 92 21 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 92 22 cells cell NNS cord-302953-gr2kk9w4 92 23 treated treat VBN cord-302953-gr2kk9w4 92 24 with with IN cord-302953-gr2kk9w4 92 25 IFN IFN NNP cord-302953-gr2kk9w4 92 26 - - HYPH cord-302953-gr2kk9w4 92 27 γ γ NNP cord-302953-gr2kk9w4 92 28 , , , cord-302953-gr2kk9w4 92 29 as as IN cord-302953-gr2kk9w4 92 30 were be VBD cord-302953-gr2kk9w4 92 31 Oasl2 oasl2 JJ cord-302953-gr2kk9w4 92 32 ( ( -LRB- cord-302953-gr2kk9w4 92 33 Figure Figure NNP cord-302953-gr2kk9w4 92 34 2C 2C NNP cord-302953-gr2kk9w4 92 35 ) ) -RRB- cord-302953-gr2kk9w4 92 36 , , , cord-302953-gr2kk9w4 92 37 a a DT cord-302953-gr2kk9w4 92 38 member member NN cord-302953-gr2kk9w4 92 39 of of IN cord-302953-gr2kk9w4 92 40 the the DT cord-302953-gr2kk9w4 92 41 2'-5'oligoadenylate 2'-5'oligoadenylate CD cord-302953-gr2kk9w4 92 42 / / SYM cord-302953-gr2kk9w4 92 43 RNaseL rnasel NN cord-302953-gr2kk9w4 92 44 system system NN cord-302953-gr2kk9w4 92 45 [ [ -LRB- cord-302953-gr2kk9w4 92 46 26 26 CD cord-302953-gr2kk9w4 92 47 ] ] -RRB- cord-302953-gr2kk9w4 92 48 , , , cord-302953-gr2kk9w4 92 49 and and CC cord-302953-gr2kk9w4 92 50 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 92 51 ( ( -LRB- cord-302953-gr2kk9w4 92 52 Figure Figure NNP cord-302953-gr2kk9w4 92 53 2D 2D NNP cord-302953-gr2kk9w4 92 54 ) ) -RRB- cord-302953-gr2kk9w4 92 55 , , , cord-302953-gr2kk9w4 92 56 which which WDT cord-302953-gr2kk9w4 92 57 encodes encode VBZ cord-302953-gr2kk9w4 92 58 viperin viperin NNP cord-302953-gr2kk9w4 92 59 , , , cord-302953-gr2kk9w4 92 60 a a DT cord-302953-gr2kk9w4 92 61 protein protein NN cord-302953-gr2kk9w4 92 62 that that WDT cord-302953-gr2kk9w4 92 63 interferes interfere VBZ cord-302953-gr2kk9w4 92 64 with with IN cord-302953-gr2kk9w4 92 65 assembly assembly NN cord-302953-gr2kk9w4 92 66 and and CC cord-302953-gr2kk9w4 92 67 release release NN cord-302953-gr2kk9w4 92 68 of of IN cord-302953-gr2kk9w4 92 69 many many JJ cord-302953-gr2kk9w4 92 70 viruses virus NNS cord-302953-gr2kk9w4 92 71 [ [ -LRB- cord-302953-gr2kk9w4 92 72 27 27 CD cord-302953-gr2kk9w4 92 73 ] ] -RRB- cord-302953-gr2kk9w4 92 74 . . . cord-302953-gr2kk9w4 93 1 Zc3hav1 zc3hav1 NN cord-302953-gr2kk9w4 94 1 ( ( -LRB- cord-302953-gr2kk9w4 94 2 Figure figure NN cord-302953-gr2kk9w4 94 3 2E 2E NNP cord-302953-gr2kk9w4 94 4 ) ) -RRB- cord-302953-gr2kk9w4 94 5 , , , cord-302953-gr2kk9w4 94 6 which which WDT cord-302953-gr2kk9w4 94 7 encodes encode VBZ cord-302953-gr2kk9w4 94 8 ZAP ZAP NNP cord-302953-gr2kk9w4 94 9 / / SYM cord-302953-gr2kk9w4 94 10 PARP13 PARP13 NNP cord-302953-gr2kk9w4 94 11 , , , cord-302953-gr2kk9w4 94 12 a a DT cord-302953-gr2kk9w4 94 13 protein protein NN cord-302953-gr2kk9w4 94 14 involved involve VBN cord-302953-gr2kk9w4 94 15 in in IN cord-302953-gr2kk9w4 94 16 viral viral JJ cord-302953-gr2kk9w4 94 17 RNA RNA NNP cord-302953-gr2kk9w4 94 18 degradation degradation NN cord-302953-gr2kk9w4 94 19 and and CC cord-302953-gr2kk9w4 94 20 induction induction NN cord-302953-gr2kk9w4 94 21 of of IN cord-302953-gr2kk9w4 94 22 the the DT cord-302953-gr2kk9w4 94 23 innate innate JJ cord-302953-gr2kk9w4 94 24 immune immune JJ cord-302953-gr2kk9w4 94 25 response response NN cord-302953-gr2kk9w4 94 26 that that WDT cord-302953-gr2kk9w4 94 27 restricts restrict VBZ cord-302953-gr2kk9w4 94 28 alphavirus alphavirus NNP cord-302953-gr2kk9w4 94 29 and and CC cord-302953-gr2kk9w4 94 30 flavivirus flavivirus JJ cord-302953-gr2kk9w4 94 31 replication replication NN cord-302953-gr2kk9w4 94 32 [ [ -LRB- cord-302953-gr2kk9w4 94 33 28 28 CD cord-302953-gr2kk9w4 94 34 , , , cord-302953-gr2kk9w4 94 35 29 29 CD cord-302953-gr2kk9w4 94 36 ] ] -RRB- cord-302953-gr2kk9w4 94 37 , , , cord-302953-gr2kk9w4 94 38 was be VBD cord-302953-gr2kk9w4 94 39 less less RBR cord-302953-gr2kk9w4 94 40 highly highly RB cord-302953-gr2kk9w4 94 41 upregulated upregulate VBN cord-302953-gr2kk9w4 94 42 . . . cord-302953-gr2kk9w4 95 1 All all DT cord-302953-gr2kk9w4 95 2 of of IN cord-302953-gr2kk9w4 95 3 these these DT cord-302953-gr2kk9w4 95 4 genes gene NNS cord-302953-gr2kk9w4 95 5 required require VBD cord-302953-gr2kk9w4 95 6 IFN IFN NNP cord-302953-gr2kk9w4 95 7 - - HYPH cord-302953-gr2kk9w4 95 8 γ γ NNP cord-302953-gr2kk9w4 95 9 for for IN cord-302953-gr2kk9w4 95 10 induction induction NN cord-302953-gr2kk9w4 95 11 and and CC cord-302953-gr2kk9w4 95 12 generally generally RB cord-302953-gr2kk9w4 95 13 were be VBD cord-302953-gr2kk9w4 95 14 not not RB cord-302953-gr2kk9w4 95 15 induced induce VBN cord-302953-gr2kk9w4 95 16 by by IN cord-302953-gr2kk9w4 95 17 SINV SINV NNP cord-302953-gr2kk9w4 95 18 infection infection NN cord-302953-gr2kk9w4 95 19 alone alone RB cord-302953-gr2kk9w4 95 20 . . . cord-302953-gr2kk9w4 95 21 _SP cord-302953-gr2kk9w4 96 1 Because because IN cord-302953-gr2kk9w4 96 2 IFN IFN NNP cord-302953-gr2kk9w4 96 3 - - HYPH cord-302953-gr2kk9w4 96 4 γ γ NNP cord-302953-gr2kk9w4 96 5 facilitates facilitate VBZ cord-302953-gr2kk9w4 96 6 virus virus NN cord-302953-gr2kk9w4 96 7 clearance clearance NN cord-302953-gr2kk9w4 96 8 from from IN cord-302953-gr2kk9w4 96 9 neurons neuron NNS cord-302953-gr2kk9w4 96 10 , , , cord-302953-gr2kk9w4 96 11 we -PRON- PRP cord-302953-gr2kk9w4 96 12 examined examine VBD cord-302953-gr2kk9w4 96 13 induction induction NN cord-302953-gr2kk9w4 96 14 of of IN cord-302953-gr2kk9w4 96 15 antiviral antiviral JJ cord-302953-gr2kk9w4 96 16 genes gene NNS cord-302953-gr2kk9w4 96 17 by by IN cord-302953-gr2kk9w4 96 18 IFN IFN NNP cord-302953-gr2kk9w4 96 19 - - HYPH cord-302953-gr2kk9w4 96 20 γ γ NNP cord-302953-gr2kk9w4 96 21 . . . cord-302953-gr2kk9w4 97 1 mRNA mRNA NNP cord-302953-gr2kk9w4 97 2 expression expression NN cord-302953-gr2kk9w4 97 3 of of IN cord-302953-gr2kk9w4 97 4 representative representative JJ cord-302953-gr2kk9w4 97 5 antiviral antiviral JJ cord-302953-gr2kk9w4 97 6 ISGs ISGs NNPS cord-302953-gr2kk9w4 97 7 was be VBD cord-302953-gr2kk9w4 97 8 examined examine VBN cord-302953-gr2kk9w4 97 9 by by IN cord-302953-gr2kk9w4 97 10 qRT qRT NNP cord-302953-gr2kk9w4 97 11 - - HYPH cord-302953-gr2kk9w4 97 12 PCR PCR NNP cord-302953-gr2kk9w4 97 13 in in IN cord-302953-gr2kk9w4 97 14 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 97 15 cells cell NNS cord-302953-gr2kk9w4 97 16 infected infect VBN cord-302953-gr2kk9w4 97 17 with with IN cord-302953-gr2kk9w4 97 18 SINV SINV NNP cord-302953-gr2kk9w4 97 19 ( ( -LRB- cord-302953-gr2kk9w4 97 20 MOI MOI NNP cord-302953-gr2kk9w4 97 21 = = SYM cord-302953-gr2kk9w4 97 22 1 1 CD cord-302953-gr2kk9w4 97 23 ) ) -RRB- cord-302953-gr2kk9w4 97 24 and and CC cord-302953-gr2kk9w4 97 25 treated treat VBN cord-302953-gr2kk9w4 97 26 with with IN cord-302953-gr2kk9w4 97 27 500 500 CD cord-302953-gr2kk9w4 97 28 U u NN cord-302953-gr2kk9w4 97 29 / / SYM cord-302953-gr2kk9w4 97 30 mL ml NN cord-302953-gr2kk9w4 97 31 IFN IFN NNP cord-302953-gr2kk9w4 97 32 - - HYPH cord-302953-gr2kk9w4 97 33 γ γ NN cord-302953-gr2kk9w4 97 34 at at IN cord-302953-gr2kk9w4 97 35 2 2 CD cord-302953-gr2kk9w4 97 36 HPI HPI NNP cord-302953-gr2kk9w4 97 37 . . . cord-302953-gr2kk9w4 98 1 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 98 2 ( ( -LRB- cord-302953-gr2kk9w4 98 3 Figure Figure NNP cord-302953-gr2kk9w4 98 4 2A 2a CD cord-302953-gr2kk9w4 98 5 ) ) -RRB- cord-302953-gr2kk9w4 98 6 and and CC cord-302953-gr2kk9w4 98 7 Irgm Irgm NNP cord-302953-gr2kk9w4 98 8 ( ( -LRB- cord-302953-gr2kk9w4 98 9 Figure Figure NNP cord-302953-gr2kk9w4 98 10 2B 2b CD cord-302953-gr2kk9w4 98 11 ) ) -RRB- cord-302953-gr2kk9w4 98 12 , , , cord-302953-gr2kk9w4 98 13 two two CD cord-302953-gr2kk9w4 98 14 genes gene NNS cord-302953-gr2kk9w4 98 15 associated associate VBN cord-302953-gr2kk9w4 98 16 with with IN cord-302953-gr2kk9w4 98 17 autophagy autophagy NN cord-302953-gr2kk9w4 98 18 [ [ -LRB- cord-302953-gr2kk9w4 98 19 25 25 CD cord-302953-gr2kk9w4 98 20 ] ] -RRB- cord-302953-gr2kk9w4 98 21 , , , cord-302953-gr2kk9w4 98 22 were be VBD cord-302953-gr2kk9w4 98 23 highly highly RB cord-302953-gr2kk9w4 98 24 expressed express VBN cord-302953-gr2kk9w4 98 25 by by IN cord-302953-gr2kk9w4 98 26 SINV SINV NNP cord-302953-gr2kk9w4 98 27 - - HYPH cord-302953-gr2kk9w4 98 28 infected infect VBN cord-302953-gr2kk9w4 98 29 dAP-7 dAP-7 NNP cord-302953-gr2kk9w4 98 30 cells cell NNS cord-302953-gr2kk9w4 98 31 treated treat VBN cord-302953-gr2kk9w4 98 32 with with IN cord-302953-gr2kk9w4 98 33 IFN IFN NNP cord-302953-gr2kk9w4 98 34 - - HYPH cord-302953-gr2kk9w4 98 35 γ γ NNP cord-302953-gr2kk9w4 98 36 , , , cord-302953-gr2kk9w4 98 37 as as IN cord-302953-gr2kk9w4 98 38 were be VBD cord-302953-gr2kk9w4 98 39 Oasl2 oasl2 JJ cord-302953-gr2kk9w4 98 40 ( ( -LRB- cord-302953-gr2kk9w4 98 41 Figure Figure NNP cord-302953-gr2kk9w4 98 42 2C 2C NNP cord-302953-gr2kk9w4 98 43 ) ) -RRB- cord-302953-gr2kk9w4 98 44 , , , cord-302953-gr2kk9w4 98 45 a a DT cord-302953-gr2kk9w4 98 46 member member NN cord-302953-gr2kk9w4 98 47 of of IN cord-302953-gr2kk9w4 98 48 the the DT cord-302953-gr2kk9w4 98 49 2'-5'oligoadenylate 2'-5'oligoadenylate CD cord-302953-gr2kk9w4 98 50 / / SYM cord-302953-gr2kk9w4 98 51 RNaseL rnasel NN cord-302953-gr2kk9w4 98 52 system system NN cord-302953-gr2kk9w4 98 53 [ [ -LRB- cord-302953-gr2kk9w4 98 54 26 26 CD cord-302953-gr2kk9w4 98 55 ] ] -RRB- cord-302953-gr2kk9w4 98 56 , , , cord-302953-gr2kk9w4 98 57 and and CC cord-302953-gr2kk9w4 98 58 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 98 59 ( ( -LRB- cord-302953-gr2kk9w4 98 60 Figure Figure NNP cord-302953-gr2kk9w4 98 61 2D 2D NNP cord-302953-gr2kk9w4 98 62 ) ) -RRB- cord-302953-gr2kk9w4 98 63 , , , cord-302953-gr2kk9w4 98 64 which which WDT cord-302953-gr2kk9w4 98 65 encodes encode VBZ cord-302953-gr2kk9w4 98 66 viperin viperin NNP cord-302953-gr2kk9w4 98 67 , , , cord-302953-gr2kk9w4 98 68 a a DT cord-302953-gr2kk9w4 98 69 protein protein NN cord-302953-gr2kk9w4 98 70 that that WDT cord-302953-gr2kk9w4 98 71 interferes interfere VBZ cord-302953-gr2kk9w4 98 72 with with IN cord-302953-gr2kk9w4 98 73 assembly assembly NN cord-302953-gr2kk9w4 98 74 and and CC cord-302953-gr2kk9w4 98 75 release release NN cord-302953-gr2kk9w4 98 76 of of IN cord-302953-gr2kk9w4 98 77 many many JJ cord-302953-gr2kk9w4 98 78 viruses virus NNS cord-302953-gr2kk9w4 98 79 [ [ -LRB- cord-302953-gr2kk9w4 98 80 27 27 CD cord-302953-gr2kk9w4 98 81 ] ] -RRB- cord-302953-gr2kk9w4 98 82 . . . cord-302953-gr2kk9w4 99 1 Zc3hav1 zc3hav1 NN cord-302953-gr2kk9w4 100 1 ( ( -LRB- cord-302953-gr2kk9w4 100 2 Figure figure NN cord-302953-gr2kk9w4 100 3 2E 2E NNP cord-302953-gr2kk9w4 100 4 ) ) -RRB- cord-302953-gr2kk9w4 100 5 , , , cord-302953-gr2kk9w4 100 6 which which WDT cord-302953-gr2kk9w4 100 7 encodes encode VBZ cord-302953-gr2kk9w4 100 8 ZAP ZAP NNP cord-302953-gr2kk9w4 100 9 / / SYM cord-302953-gr2kk9w4 100 10 PARP13 PARP13 NNP cord-302953-gr2kk9w4 100 11 , , , cord-302953-gr2kk9w4 100 12 a a DT cord-302953-gr2kk9w4 100 13 protein protein NN cord-302953-gr2kk9w4 100 14 involved involve VBN cord-302953-gr2kk9w4 100 15 in in IN cord-302953-gr2kk9w4 100 16 viral viral JJ cord-302953-gr2kk9w4 100 17 RNA RNA NNP cord-302953-gr2kk9w4 100 18 degradation degradation NN cord-302953-gr2kk9w4 100 19 and and CC cord-302953-gr2kk9w4 100 20 induction induction NN cord-302953-gr2kk9w4 100 21 of of IN cord-302953-gr2kk9w4 100 22 the the DT cord-302953-gr2kk9w4 100 23 innate innate JJ cord-302953-gr2kk9w4 100 24 immune immune JJ cord-302953-gr2kk9w4 100 25 response response NN cord-302953-gr2kk9w4 100 26 that that WDT cord-302953-gr2kk9w4 100 27 restricts restrict VBZ cord-302953-gr2kk9w4 100 28 alphavirus alphavirus NNP cord-302953-gr2kk9w4 100 29 and and CC cord-302953-gr2kk9w4 100 30 flavivirus flavivirus JJ cord-302953-gr2kk9w4 100 31 replication replication NN cord-302953-gr2kk9w4 100 32 [ [ -LRB- cord-302953-gr2kk9w4 100 33 28 28 CD cord-302953-gr2kk9w4 100 34 , , , cord-302953-gr2kk9w4 100 35 29 29 CD cord-302953-gr2kk9w4 100 36 ] ] -RRB- cord-302953-gr2kk9w4 100 37 , , , cord-302953-gr2kk9w4 100 38 was be VBD cord-302953-gr2kk9w4 100 39 less less RBR cord-302953-gr2kk9w4 100 40 highly highly RB cord-302953-gr2kk9w4 100 41 upregulated upregulate VBN cord-302953-gr2kk9w4 100 42 . . . cord-302953-gr2kk9w4 101 1 All all DT cord-302953-gr2kk9w4 101 2 of of IN cord-302953-gr2kk9w4 101 3 these these DT cord-302953-gr2kk9w4 101 4 genes gene NNS cord-302953-gr2kk9w4 101 5 required require VBD cord-302953-gr2kk9w4 101 6 IFN IFN NNP cord-302953-gr2kk9w4 101 7 - - HYPH cord-302953-gr2kk9w4 101 8 γ γ NNP cord-302953-gr2kk9w4 101 9 for for IN cord-302953-gr2kk9w4 101 10 induction induction NN cord-302953-gr2kk9w4 101 11 and and CC cord-302953-gr2kk9w4 101 12 generally generally RB cord-302953-gr2kk9w4 101 13 were be VBD cord-302953-gr2kk9w4 101 14 not not RB cord-302953-gr2kk9w4 101 15 induced induce VBN cord-302953-gr2kk9w4 101 16 by by IN cord-302953-gr2kk9w4 101 17 SINV SINV NNP cord-302953-gr2kk9w4 101 18 infection infection NN cord-302953-gr2kk9w4 101 19 alone alone RB cord-302953-gr2kk9w4 101 20 . . . cord-302953-gr2kk9w4 101 21 _SP cord-302953-gr2kk9w4 102 1 To to TO cord-302953-gr2kk9w4 102 2 characterize characterize VB cord-302953-gr2kk9w4 102 3 the the DT cord-302953-gr2kk9w4 102 4 time time NN cord-302953-gr2kk9w4 102 5 course course NN cord-302953-gr2kk9w4 102 6 and and CC cord-302953-gr2kk9w4 102 7 source source NN cord-302953-gr2kk9w4 102 8 of of IN cord-302953-gr2kk9w4 102 9 IFN IFN NNP cord-302953-gr2kk9w4 102 10 - - HYPH cord-302953-gr2kk9w4 102 11 γ γ NNP cord-302953-gr2kk9w4 102 12 throughout throughout IN cord-302953-gr2kk9w4 102 13 the the DT cord-302953-gr2kk9w4 102 14 course course NN cord-302953-gr2kk9w4 102 15 of of IN cord-302953-gr2kk9w4 102 16 SINV SINV NNP cord-302953-gr2kk9w4 102 17 infection infection NN cord-302953-gr2kk9w4 102 18 of of IN cord-302953-gr2kk9w4 102 19 the the DT cord-302953-gr2kk9w4 102 20 CNS CNS NNP cord-302953-gr2kk9w4 102 21 , , , cord-302953-gr2kk9w4 102 22 flow flow NN cord-302953-gr2kk9w4 102 23 cytometry cytometry NN cord-302953-gr2kk9w4 102 24 was be VBD cord-302953-gr2kk9w4 102 25 used use VBN cord-302953-gr2kk9w4 102 26 to to TO cord-302953-gr2kk9w4 102 27 characterize characterize VB cord-302953-gr2kk9w4 102 28 cells cell NNS cord-302953-gr2kk9w4 102 29 from from IN cord-302953-gr2kk9w4 102 30 the the DT cord-302953-gr2kk9w4 102 31 CLNs cln NNS cord-302953-gr2kk9w4 102 32 , , , cord-302953-gr2kk9w4 102 33 the the DT cord-302953-gr2kk9w4 102 34 draining drain VBG cord-302953-gr2kk9w4 102 35 lymph lymph NN cord-302953-gr2kk9w4 102 36 nodes node NNS cord-302953-gr2kk9w4 102 37 of of IN cord-302953-gr2kk9w4 102 38 the the DT cord-302953-gr2kk9w4 102 39 brain brain NN cord-302953-gr2kk9w4 102 40 , , , cord-302953-gr2kk9w4 102 41 and and CC cord-302953-gr2kk9w4 102 42 the the DT cord-302953-gr2kk9w4 102 43 brains brain NNS cord-302953-gr2kk9w4 102 44 of of IN cord-302953-gr2kk9w4 102 45 WT WT NNP cord-302953-gr2kk9w4 102 46 mice mouse NNS cord-302953-gr2kk9w4 102 47 ( ( -LRB- cord-302953-gr2kk9w4 102 48 Figure figure NN cord-302953-gr2kk9w4 102 49 3 3 CD cord-302953-gr2kk9w4 102 50 ) ) -RRB- cord-302953-gr2kk9w4 102 51 . . . cord-302953-gr2kk9w4 103 1 CD4 CD4 NNP cord-302953-gr2kk9w4 103 2 + + CC cord-302953-gr2kk9w4 103 3 T t NN cord-302953-gr2kk9w4 103 4 cells cell NNS cord-302953-gr2kk9w4 103 5 , , , cord-302953-gr2kk9w4 103 6 CD8 CD8 NNP cord-302953-gr2kk9w4 103 7 + + CC cord-302953-gr2kk9w4 103 8 T T NNP cord-302953-gr2kk9w4 103 9 cells cell NNS cord-302953-gr2kk9w4 103 10 , , , cord-302953-gr2kk9w4 103 11 and and CC cord-302953-gr2kk9w4 103 12 NK NK NNP cord-302953-gr2kk9w4 103 13 cells cell NNS cord-302953-gr2kk9w4 103 14 were be VBD cord-302953-gr2kk9w4 103 15 examined examine VBN cord-302953-gr2kk9w4 103 16 for for IN cord-302953-gr2kk9w4 103 17 cytokine cytokine NN cord-302953-gr2kk9w4 103 18 production production NN cord-302953-gr2kk9w4 103 19 during during IN cord-302953-gr2kk9w4 103 20 Phase phase NN cord-302953-gr2kk9w4 103 21 1 1 CD cord-302953-gr2kk9w4 103 22 ( ( -LRB- cord-302953-gr2kk9w4 103 23 5 5 CD cord-302953-gr2kk9w4 103 24 and and CC cord-302953-gr2kk9w4 103 25 7 7 CD cord-302953-gr2kk9w4 103 26 DPI DPI NNP cord-302953-gr2kk9w4 103 27 ) ) -RRB- cord-302953-gr2kk9w4 103 28 , , , cord-302953-gr2kk9w4 103 29 Phase phase NN cord-302953-gr2kk9w4 103 30 2 2 CD cord-302953-gr2kk9w4 103 31 ( ( -LRB- cord-302953-gr2kk9w4 103 32 10 10 CD cord-302953-gr2kk9w4 103 33 and and CC cord-302953-gr2kk9w4 103 34 14 14 CD cord-302953-gr2kk9w4 103 35 DPI DPI NNP cord-302953-gr2kk9w4 103 36 ) ) -RRB- cord-302953-gr2kk9w4 103 37 , , , cord-302953-gr2kk9w4 103 38 and and CC cord-302953-gr2kk9w4 103 39 Phase phase NN cord-302953-gr2kk9w4 103 40 3 3 CD cord-302953-gr2kk9w4 103 41 ( ( -LRB- cord-302953-gr2kk9w4 103 42 90 90 CD cord-302953-gr2kk9w4 103 43 DPI DPI NNP cord-302953-gr2kk9w4 103 44 ) ) -RRB- cord-302953-gr2kk9w4 103 45 of of IN cord-302953-gr2kk9w4 103 46 infection infection NN cord-302953-gr2kk9w4 103 47 . . . cord-302953-gr2kk9w4 104 1 In in IN cord-302953-gr2kk9w4 104 2 the the DT cord-302953-gr2kk9w4 104 3 CLNs cln NNS cord-302953-gr2kk9w4 104 4 , , , cord-302953-gr2kk9w4 104 5 few few JJ cord-302953-gr2kk9w4 104 6 cells cell NNS cord-302953-gr2kk9w4 104 7 produced produce VBD cord-302953-gr2kk9w4 104 8 IFN IFN NNP cord-302953-gr2kk9w4 104 9 - - HYPH cord-302953-gr2kk9w4 104 10 γ γ NNP cord-302953-gr2kk9w4 104 11 at at IN cord-302953-gr2kk9w4 104 12 any any DT cord-302953-gr2kk9w4 104 13 time time NN cord-302953-gr2kk9w4 104 14 ( ( -LRB- cord-302953-gr2kk9w4 104 15 Figure figure NN cord-302953-gr2kk9w4 104 16 3A 3a NN cord-302953-gr2kk9w4 104 17 , , , cord-302953-gr2kk9w4 104 18 C C NNP cord-302953-gr2kk9w4 104 19 ) ) -RRB- cord-302953-gr2kk9w4 104 20 . . . cord-302953-gr2kk9w4 105 1 In in IN cord-302953-gr2kk9w4 105 2 the the DT cord-302953-gr2kk9w4 105 3 brain brain NN cord-302953-gr2kk9w4 105 4 , , , cord-302953-gr2kk9w4 105 5 NK NK NNP cord-302953-gr2kk9w4 105 6 cells cell NNS cord-302953-gr2kk9w4 105 7 were be VBD cord-302953-gr2kk9w4 105 8 the the DT cord-302953-gr2kk9w4 105 9 predominant predominant JJ cord-302953-gr2kk9w4 105 10 source source NN cord-302953-gr2kk9w4 105 11 of of IN cord-302953-gr2kk9w4 105 12 IFN IFN NNP cord-302953-gr2kk9w4 105 13 - - HYPH cord-302953-gr2kk9w4 105 14 γ γ NNP cord-302953-gr2kk9w4 105 15 at at IN cord-302953-gr2kk9w4 105 16 5 5 CD cord-302953-gr2kk9w4 105 17 DPI DPI NNP cord-302953-gr2kk9w4 105 18 , , , cord-302953-gr2kk9w4 105 19 both both DT cord-302953-gr2kk9w4 105 20 as as IN cord-302953-gr2kk9w4 105 21 percentage percentage NN cord-302953-gr2kk9w4 105 22 of of IN cord-302953-gr2kk9w4 105 23 live live JJ cord-302953-gr2kk9w4 105 24 cells cell NNS cord-302953-gr2kk9w4 105 25 and and CC cord-302953-gr2kk9w4 105 26 absolute absolute JJ cord-302953-gr2kk9w4 105 27 numbers number NNS cord-302953-gr2kk9w4 105 28 ( ( -LRB- cord-302953-gr2kk9w4 105 29 Figure figure NN cord-302953-gr2kk9w4 105 30 3B 3b NN cord-302953-gr2kk9w4 105 31 , , , cord-302953-gr2kk9w4 105 32 D D NNP cord-302953-gr2kk9w4 105 33 ) ) -RRB- cord-302953-gr2kk9w4 105 34 . . . cord-302953-gr2kk9w4 106 1 Numbers number NNS cord-302953-gr2kk9w4 106 2 of of IN cord-302953-gr2kk9w4 106 3 IFN IFN NNP cord-302953-gr2kk9w4 106 4 - - HYPH cord-302953-gr2kk9w4 106 5 γ γ NNP cord-302953-gr2kk9w4 106 6 - - HYPH cord-302953-gr2kk9w4 106 7 producing produce VBG cord-302953-gr2kk9w4 106 8 cells cell NNS cord-302953-gr2kk9w4 106 9 in in IN cord-302953-gr2kk9w4 106 10 the the DT cord-302953-gr2kk9w4 106 11 brain brain NN cord-302953-gr2kk9w4 106 12 peaked peak VBD cord-302953-gr2kk9w4 106 13 at at IN cord-302953-gr2kk9w4 106 14 7 7 CD cord-302953-gr2kk9w4 106 15 DPI DPI NNP cord-302953-gr2kk9w4 106 16 and and CC cord-302953-gr2kk9w4 106 17 were be VBD cord-302953-gr2kk9w4 106 18 predominantly predominantly RB cord-302953-gr2kk9w4 106 19 CD8 CD8 NNP cord-302953-gr2kk9w4 106 20 + + CC cord-302953-gr2kk9w4 106 21 T T NNP cord-302953-gr2kk9w4 106 22 cells cell NNS cord-302953-gr2kk9w4 106 23 . . . cord-302953-gr2kk9w4 107 1 As as IN cord-302953-gr2kk9w4 107 2 CD8 CD8 NNP cord-302953-gr2kk9w4 107 3 + + CC cord-302953-gr2kk9w4 107 4 T T NNP cord-302953-gr2kk9w4 107 5 cells cell NNS cord-302953-gr2kk9w4 107 6 decreased decrease VBD cord-302953-gr2kk9w4 107 7 , , , cord-302953-gr2kk9w4 107 8 CD4 CD4 NNP cord-302953-gr2kk9w4 107 9 + + CC cord-302953-gr2kk9w4 107 10 T t NN cord-302953-gr2kk9w4 107 11 cells cell NNS cord-302953-gr2kk9w4 107 12 became become VBD cord-302953-gr2kk9w4 107 13 comparable comparable JJ cord-302953-gr2kk9w4 107 14 contributors contributor NNS cord-302953-gr2kk9w4 107 15 by by IN cord-302953-gr2kk9w4 107 16 14 14 CD cord-302953-gr2kk9w4 107 17 DPI DPI NNP cord-302953-gr2kk9w4 107 18 . . . cord-302953-gr2kk9w4 108 1 In in IN cord-302953-gr2kk9w4 108 2 Phase phase NN cord-302953-gr2kk9w4 108 3 3 3 CD cord-302953-gr2kk9w4 108 4 of of IN cord-302953-gr2kk9w4 108 5 infection infection NN cord-302953-gr2kk9w4 108 6 , , , cord-302953-gr2kk9w4 108 7 fewer few JJR cord-302953-gr2kk9w4 108 8 T t NN cord-302953-gr2kk9w4 108 9 cells cell NNS cord-302953-gr2kk9w4 108 10 were be VBD cord-302953-gr2kk9w4 108 11 present present JJ cord-302953-gr2kk9w4 108 12 in in IN cord-302953-gr2kk9w4 108 13 the the DT cord-302953-gr2kk9w4 108 14 brains brain NNS cord-302953-gr2kk9w4 108 15 and and CC cord-302953-gr2kk9w4 108 16 CD8 CD8 NNP cord-302953-gr2kk9w4 108 17 + + CC cord-302953-gr2kk9w4 108 18 and and CC cord-302953-gr2kk9w4 108 19 CD4 CD4 NNP cord-302953-gr2kk9w4 108 20 + + CC cord-302953-gr2kk9w4 108 21 T t NN cord-302953-gr2kk9w4 108 22 cells cell NNS cord-302953-gr2kk9w4 108 23 produced produce VBD cord-302953-gr2kk9w4 108 24 the the DT cord-302953-gr2kk9w4 108 25 majority majority NN cord-302953-gr2kk9w4 108 26 of of IN cord-302953-gr2kk9w4 108 27 IFN IFN NNP cord-302953-gr2kk9w4 108 28 - - HYPH cord-302953-gr2kk9w4 108 29 γ γ NNP cord-302953-gr2kk9w4 108 30 . . . cord-302953-gr2kk9w4 109 1 Therefore therefore RB cord-302953-gr2kk9w4 109 2 , , , cord-302953-gr2kk9w4 109 3 NK NK NNP cord-302953-gr2kk9w4 109 4 cells cell NNS cord-302953-gr2kk9w4 109 5 produce produce VBP cord-302953-gr2kk9w4 109 6 most most JJS cord-302953-gr2kk9w4 109 7 of of IN cord-302953-gr2kk9w4 109 8 the the DT cord-302953-gr2kk9w4 109 9 local local JJ cord-302953-gr2kk9w4 109 10 CNS CNS NNP cord-302953-gr2kk9w4 109 11 IFN IFN NNP cord-302953-gr2kk9w4 109 12 - - HYPH cord-302953-gr2kk9w4 109 13 γ γ NNP cord-302953-gr2kk9w4 109 14 early early RB cord-302953-gr2kk9w4 109 15 in in IN cord-302953-gr2kk9w4 109 16 the the DT cord-302953-gr2kk9w4 109 17 course course NN cord-302953-gr2kk9w4 109 18 of of IN cord-302953-gr2kk9w4 109 19 infection infection NN cord-302953-gr2kk9w4 109 20 , , , cord-302953-gr2kk9w4 109 21 but but CC cord-302953-gr2kk9w4 109 22 at at IN cord-302953-gr2kk9w4 109 23 later later JJ cord-302953-gr2kk9w4 109 24 times time NNS cord-302953-gr2kk9w4 109 25 , , , cord-302953-gr2kk9w4 109 26 CD4 CD4 NNP cord-302953-gr2kk9w4 109 27 + + CC cord-302953-gr2kk9w4 109 28 , , , cord-302953-gr2kk9w4 109 29 and and CC cord-302953-gr2kk9w4 109 30 especially especially RB cord-302953-gr2kk9w4 109 31 CD8 CD8 NNP cord-302953-gr2kk9w4 110 1 + + UH cord-302953-gr2kk9w4 110 2 , , , cord-302953-gr2kk9w4 110 3 T t NN cord-302953-gr2kk9w4 110 4 cells cell NNS cord-302953-gr2kk9w4 110 5 become become VBP cord-302953-gr2kk9w4 110 6 the the DT cord-302953-gr2kk9w4 110 7 predominant predominant JJ cord-302953-gr2kk9w4 110 8 source source NN cord-302953-gr2kk9w4 110 9 . . . cord-302953-gr2kk9w4 111 1 We -PRON- PRP cord-302953-gr2kk9w4 111 2 next next RB cord-302953-gr2kk9w4 111 3 characterized characterize VBD cord-302953-gr2kk9w4 111 4 the the DT cord-302953-gr2kk9w4 111 5 percentages percentage NNS cord-302953-gr2kk9w4 111 6 of of IN cord-302953-gr2kk9w4 111 7 each each DT cord-302953-gr2kk9w4 111 8 cell cell NN cord-302953-gr2kk9w4 111 9 population population NN cord-302953-gr2kk9w4 111 10 producing produce VBG cord-302953-gr2kk9w4 111 11 IFN IFN NNP cord-302953-gr2kk9w4 111 12 - - HYPH cord-302953-gr2kk9w4 111 13 γ γ NNP cord-302953-gr2kk9w4 111 14 . . . cord-302953-gr2kk9w4 112 1 Little little JJ cord-302953-gr2kk9w4 112 2 change change NN cord-302953-gr2kk9w4 112 3 was be VBD cord-302953-gr2kk9w4 112 4 seen see VBN cord-302953-gr2kk9w4 112 5 in in IN cord-302953-gr2kk9w4 112 6 the the DT cord-302953-gr2kk9w4 112 7 CLNs cln NNS cord-302953-gr2kk9w4 112 8 , , , cord-302953-gr2kk9w4 112 9 with with IN cord-302953-gr2kk9w4 112 10 less less JJR cord-302953-gr2kk9w4 112 11 than than IN cord-302953-gr2kk9w4 112 12 10 10 CD cord-302953-gr2kk9w4 112 13 % % NN cord-302953-gr2kk9w4 112 14 of of IN cord-302953-gr2kk9w4 112 15 CD4 CD4 NNP cord-302953-gr2kk9w4 112 16 + + CC cord-302953-gr2kk9w4 112 17 T t NN cord-302953-gr2kk9w4 112 18 cells cell NNS cord-302953-gr2kk9w4 112 19 , , , cord-302953-gr2kk9w4 112 20 less less JJR cord-302953-gr2kk9w4 112 21 than than IN cord-302953-gr2kk9w4 112 22 20 20 CD cord-302953-gr2kk9w4 112 23 % % NN cord-302953-gr2kk9w4 112 24 of of IN cord-302953-gr2kk9w4 112 25 CD8 CD8 NNP cord-302953-gr2kk9w4 112 26 + + CC cord-302953-gr2kk9w4 112 27 T T NNP cord-302953-gr2kk9w4 112 28 cells cell NNS cord-302953-gr2kk9w4 112 29 , , , cord-302953-gr2kk9w4 112 30 and and CC cord-302953-gr2kk9w4 112 31 20 20 CD cord-302953-gr2kk9w4 112 32 - - SYM cord-302953-gr2kk9w4 112 33 40 40 CD cord-302953-gr2kk9w4 112 34 % % NN cord-302953-gr2kk9w4 112 35 of of IN cord-302953-gr2kk9w4 112 36 NK NK NNP cord-302953-gr2kk9w4 112 37 cells cell NNS cord-302953-gr2kk9w4 112 38 producing produce VBG cord-302953-gr2kk9w4 112 39 IFN IFN NNP cord-302953-gr2kk9w4 112 40 - - HYPH cord-302953-gr2kk9w4 112 41 γ γ NN cord-302953-gr2kk9w4 112 42 at at IN cord-302953-gr2kk9w4 112 43 any any DT cord-302953-gr2kk9w4 112 44 time time NN cord-302953-gr2kk9w4 112 45 after after IN cord-302953-gr2kk9w4 112 46 infection infection NN cord-302953-gr2kk9w4 112 47 ( ( -LRB- cord-302953-gr2kk9w4 112 48 Figure Figure NNP cord-302953-gr2kk9w4 112 49 3E 3e NN cord-302953-gr2kk9w4 112 50 ) ) -RRB- cord-302953-gr2kk9w4 112 51 . . . cord-302953-gr2kk9w4 113 1 In in IN cord-302953-gr2kk9w4 113 2 the the DT cord-302953-gr2kk9w4 113 3 brain brain NN cord-302953-gr2kk9w4 113 4 , , , cord-302953-gr2kk9w4 113 5 the the DT cord-302953-gr2kk9w4 113 6 percentage percentage NN cord-302953-gr2kk9w4 113 7 of of IN cord-302953-gr2kk9w4 113 8 CD4 CD4 NNP cord-302953-gr2kk9w4 113 9 + + CC cord-302953-gr2kk9w4 113 10 and and CC cord-302953-gr2kk9w4 113 11 CD8 CD8 NNP cord-302953-gr2kk9w4 113 12 + + CC cord-302953-gr2kk9w4 113 13 T T NNP cord-302953-gr2kk9w4 113 14 cells cell NNS cord-302953-gr2kk9w4 113 15 producing produce VBG cord-302953-gr2kk9w4 113 16 IFN IFN NNP cord-302953-gr2kk9w4 113 17 - - HYPH cord-302953-gr2kk9w4 113 18 γ γ NNP cord-302953-gr2kk9w4 113 19 increased increase VBD cord-302953-gr2kk9w4 113 20 over over IN cord-302953-gr2kk9w4 113 21 the the DT cord-302953-gr2kk9w4 113 22 course course NN cord-302953-gr2kk9w4 113 23 of of IN cord-302953-gr2kk9w4 113 24 infection infection NN cord-302953-gr2kk9w4 113 25 , , , cord-302953-gr2kk9w4 113 26 going go VBG cord-302953-gr2kk9w4 113 27 from from IN cord-302953-gr2kk9w4 113 28 approximately approximately RB cord-302953-gr2kk9w4 113 29 40 40 CD cord-302953-gr2kk9w4 113 30 to to TO cord-302953-gr2kk9w4 113 31 60 60 CD cord-302953-gr2kk9w4 113 32 % % NN cord-302953-gr2kk9w4 113 33 at at IN cord-302953-gr2kk9w4 113 34 5 5 CD cord-302953-gr2kk9w4 113 35 and and CC cord-302953-gr2kk9w4 113 36 7 7 CD cord-302953-gr2kk9w4 113 37 DPI DPI NNP cord-302953-gr2kk9w4 113 38 to to IN cord-302953-gr2kk9w4 113 39 over over IN cord-302953-gr2kk9w4 113 40 80 80 CD cord-302953-gr2kk9w4 113 41 % % NN cord-302953-gr2kk9w4 113 42 at at IN cord-302953-gr2kk9w4 113 43 10 10 CD cord-302953-gr2kk9w4 113 44 , , , cord-302953-gr2kk9w4 113 45 14 14 CD cord-302953-gr2kk9w4 113 46 , , , cord-302953-gr2kk9w4 113 47 and and CC cord-302953-gr2kk9w4 113 48 90 90 CD cord-302953-gr2kk9w4 113 49 DPI DPI NNP cord-302953-gr2kk9w4 113 50 ( ( -LRB- cord-302953-gr2kk9w4 113 51 Figure Figure NNP cord-302953-gr2kk9w4 113 52 3F 3F NNP cord-302953-gr2kk9w4 113 53 ) ) -RRB- cord-302953-gr2kk9w4 113 54 . . . cord-302953-gr2kk9w4 114 1 In in IN cord-302953-gr2kk9w4 114 2 contrast contrast NN cord-302953-gr2kk9w4 114 3 , , , cord-302953-gr2kk9w4 114 4 the the DT cord-302953-gr2kk9w4 114 5 percentage percentage NN cord-302953-gr2kk9w4 114 6 of of IN cord-302953-gr2kk9w4 114 7 brain brain NN cord-302953-gr2kk9w4 114 8 NK NK NNP cord-302953-gr2kk9w4 114 9 cells cell NNS cord-302953-gr2kk9w4 114 10 producing produce VBG cord-302953-gr2kk9w4 114 11 IFN IFN NNP cord-302953-gr2kk9w4 114 12 - - HYPH cord-302953-gr2kk9w4 114 13 γ γ NNP cord-302953-gr2kk9w4 114 14 remained remain VBD cord-302953-gr2kk9w4 114 15 between between IN cord-302953-gr2kk9w4 114 16 20 20 CD cord-302953-gr2kk9w4 114 17 to to TO cord-302953-gr2kk9w4 114 18 50 50 CD cord-302953-gr2kk9w4 114 19 % % NN cord-302953-gr2kk9w4 114 20 , , , cord-302953-gr2kk9w4 114 21 similar similar JJ cord-302953-gr2kk9w4 114 22 to to IN cord-302953-gr2kk9w4 114 23 that that DT cord-302953-gr2kk9w4 114 24 in in IN cord-302953-gr2kk9w4 114 25 the the DT cord-302953-gr2kk9w4 114 26 CLNs cln NNS cord-302953-gr2kk9w4 114 27 . . . cord-302953-gr2kk9w4 115 1 To to TO cord-302953-gr2kk9w4 115 2 compare compare VB cord-302953-gr2kk9w4 115 3 the the DT cord-302953-gr2kk9w4 115 4 relative relative JJ cord-302953-gr2kk9w4 115 5 amounts amount NNS cord-302953-gr2kk9w4 115 6 of of IN cord-302953-gr2kk9w4 115 7 IFN IFN NNP cord-302953-gr2kk9w4 115 8 - - HYPH cord-302953-gr2kk9w4 115 9 γ γ NNP cord-302953-gr2kk9w4 115 10 produced produce VBN cord-302953-gr2kk9w4 115 11 by by IN cord-302953-gr2kk9w4 115 12 each each DT cord-302953-gr2kk9w4 115 13 cell cell NN cord-302953-gr2kk9w4 115 14 type type NN cord-302953-gr2kk9w4 115 15 , , , cord-302953-gr2kk9w4 115 16 median median JJ cord-302953-gr2kk9w4 115 17 fluorescence fluorescence NN cord-302953-gr2kk9w4 115 18 intensities intensity NNS cord-302953-gr2kk9w4 115 19 ( ( -LRB- cord-302953-gr2kk9w4 115 20 MFIs mfi NNS cord-302953-gr2kk9w4 115 21 ) ) -RRB- cord-302953-gr2kk9w4 115 22 were be VBD cord-302953-gr2kk9w4 115 23 determined determine VBN cord-302953-gr2kk9w4 115 24 . . . cord-302953-gr2kk9w4 116 1 In in IN cord-302953-gr2kk9w4 116 2 the the DT cord-302953-gr2kk9w4 116 3 CLNs cln NNS cord-302953-gr2kk9w4 116 4 , , , cord-302953-gr2kk9w4 116 5 the the DT cord-302953-gr2kk9w4 116 6 MFI MFI NNP cord-302953-gr2kk9w4 116 7 for for IN cord-302953-gr2kk9w4 116 8 IFN IFN NNP cord-302953-gr2kk9w4 116 9 - - HYPH cord-302953-gr2kk9w4 116 10 γ γ NNP cord-302953-gr2kk9w4 116 11 remained remain VBD cord-302953-gr2kk9w4 116 12 low low JJ cord-302953-gr2kk9w4 116 13 and and CC cord-302953-gr2kk9w4 116 14 did do VBD cord-302953-gr2kk9w4 116 15 not not RB cord-302953-gr2kk9w4 116 16 change change VB cord-302953-gr2kk9w4 116 17 for for IN cord-302953-gr2kk9w4 116 18 any any DT cord-302953-gr2kk9w4 116 19 cell cell NN cord-302953-gr2kk9w4 116 20 population population NN cord-302953-gr2kk9w4 116 21 ( ( -LRB- cord-302953-gr2kk9w4 116 22 Figure figure NN cord-302953-gr2kk9w4 116 23 3 3 CD cord-302953-gr2kk9w4 116 24 G g NN cord-302953-gr2kk9w4 116 25 , , , cord-302953-gr2kk9w4 116 26 I -PRON- PRP cord-302953-gr2kk9w4 116 27 ) ) -RRB- cord-302953-gr2kk9w4 116 28 . . . cord-302953-gr2kk9w4 117 1 However however RB cord-302953-gr2kk9w4 117 2 , , , cord-302953-gr2kk9w4 117 3 in in IN cord-302953-gr2kk9w4 117 4 the the DT cord-302953-gr2kk9w4 117 5 brain brain NN cord-302953-gr2kk9w4 117 6 , , , cord-302953-gr2kk9w4 117 7 the the DT cord-302953-gr2kk9w4 117 8 IFN IFN NNP cord-302953-gr2kk9w4 117 9 - - HYPH cord-302953-gr2kk9w4 117 10 γ γ NNP cord-302953-gr2kk9w4 117 11 MFIs mfi NNS cord-302953-gr2kk9w4 117 12 for for IN cord-302953-gr2kk9w4 117 13 CD4 CD4 NNP cord-302953-gr2kk9w4 117 14 + + CC cord-302953-gr2kk9w4 117 15 and and CC cord-302953-gr2kk9w4 117 16 CD8 CD8 NNP cord-302953-gr2kk9w4 117 17 + + CC cord-302953-gr2kk9w4 117 18 T T NNP cord-302953-gr2kk9w4 117 19 _SP cord-302953-gr2kk9w4 117 20 To to TO cord-302953-gr2kk9w4 117 21 characterize characterize VB cord-302953-gr2kk9w4 117 22 the the DT cord-302953-gr2kk9w4 117 23 time time NN cord-302953-gr2kk9w4 117 24 course course NN cord-302953-gr2kk9w4 117 25 and and CC cord-302953-gr2kk9w4 117 26 source source NN cord-302953-gr2kk9w4 117 27 of of IN cord-302953-gr2kk9w4 117 28 IFN IFN NNP cord-302953-gr2kk9w4 117 29 - - HYPH cord-302953-gr2kk9w4 117 30 γ γ NNP cord-302953-gr2kk9w4 117 31 throughout throughout IN cord-302953-gr2kk9w4 117 32 the the DT cord-302953-gr2kk9w4 117 33 course course NN cord-302953-gr2kk9w4 117 34 of of IN cord-302953-gr2kk9w4 117 35 SINV SINV NNP cord-302953-gr2kk9w4 117 36 infection infection NN cord-302953-gr2kk9w4 117 37 of of IN cord-302953-gr2kk9w4 117 38 the the DT cord-302953-gr2kk9w4 117 39 CNS CNS NNP cord-302953-gr2kk9w4 117 40 , , , cord-302953-gr2kk9w4 117 41 flow flow NN cord-302953-gr2kk9w4 117 42 cytometry cytometry NN cord-302953-gr2kk9w4 117 43 was be VBD cord-302953-gr2kk9w4 117 44 used use VBN cord-302953-gr2kk9w4 117 45 to to TO cord-302953-gr2kk9w4 117 46 characterize characterize VB cord-302953-gr2kk9w4 117 47 cells cell NNS cord-302953-gr2kk9w4 117 48 from from IN cord-302953-gr2kk9w4 117 49 the the DT cord-302953-gr2kk9w4 117 50 CLNs cln NNS cord-302953-gr2kk9w4 117 51 , , , cord-302953-gr2kk9w4 117 52 the the DT cord-302953-gr2kk9w4 117 53 draining drain VBG cord-302953-gr2kk9w4 117 54 lymph lymph NN cord-302953-gr2kk9w4 117 55 nodes node NNS cord-302953-gr2kk9w4 117 56 of of IN cord-302953-gr2kk9w4 117 57 the the DT cord-302953-gr2kk9w4 117 58 brain brain NN cord-302953-gr2kk9w4 117 59 , , , cord-302953-gr2kk9w4 117 60 and and CC cord-302953-gr2kk9w4 117 61 the the DT cord-302953-gr2kk9w4 117 62 brains brain NNS cord-302953-gr2kk9w4 117 63 of of IN cord-302953-gr2kk9w4 117 64 WT WT NNP cord-302953-gr2kk9w4 117 65 mice mouse NNS cord-302953-gr2kk9w4 117 66 ( ( -LRB- cord-302953-gr2kk9w4 117 67 Figure figure NN cord-302953-gr2kk9w4 117 68 3 3 CD cord-302953-gr2kk9w4 117 69 ) ) -RRB- cord-302953-gr2kk9w4 117 70 . . . cord-302953-gr2kk9w4 118 1 CD4 CD4 NNP cord-302953-gr2kk9w4 118 2 + + CC cord-302953-gr2kk9w4 118 3 T t NN cord-302953-gr2kk9w4 118 4 cells cell NNS cord-302953-gr2kk9w4 118 5 , , , cord-302953-gr2kk9w4 118 6 CD8 CD8 NNP cord-302953-gr2kk9w4 118 7 + + CC cord-302953-gr2kk9w4 118 8 T T NNP cord-302953-gr2kk9w4 118 9 cells cell NNS cord-302953-gr2kk9w4 118 10 , , , cord-302953-gr2kk9w4 118 11 and and CC cord-302953-gr2kk9w4 118 12 NK NK NNP cord-302953-gr2kk9w4 118 13 cells cell NNS cord-302953-gr2kk9w4 118 14 were be VBD cord-302953-gr2kk9w4 118 15 examined examine VBN cord-302953-gr2kk9w4 118 16 for for IN cord-302953-gr2kk9w4 118 17 cytokine cytokine NN cord-302953-gr2kk9w4 118 18 production production NN cord-302953-gr2kk9w4 118 19 during during IN cord-302953-gr2kk9w4 118 20 Phase phase NN cord-302953-gr2kk9w4 118 21 1 1 CD cord-302953-gr2kk9w4 118 22 ( ( -LRB- cord-302953-gr2kk9w4 118 23 5 5 CD cord-302953-gr2kk9w4 118 24 and and CC cord-302953-gr2kk9w4 118 25 7 7 CD cord-302953-gr2kk9w4 118 26 DPI DPI NNP cord-302953-gr2kk9w4 118 27 ) ) -RRB- cord-302953-gr2kk9w4 118 28 , , , cord-302953-gr2kk9w4 118 29 Phase phase NN cord-302953-gr2kk9w4 118 30 2 2 CD cord-302953-gr2kk9w4 118 31 ( ( -LRB- cord-302953-gr2kk9w4 118 32 10 10 CD cord-302953-gr2kk9w4 118 33 and and CC cord-302953-gr2kk9w4 118 34 14 14 CD cord-302953-gr2kk9w4 118 35 DPI DPI NNP cord-302953-gr2kk9w4 118 36 ) ) -RRB- cord-302953-gr2kk9w4 118 37 , , , cord-302953-gr2kk9w4 118 38 and and CC cord-302953-gr2kk9w4 118 39 Phase phase NN cord-302953-gr2kk9w4 118 40 3 3 CD cord-302953-gr2kk9w4 118 41 ( ( -LRB- cord-302953-gr2kk9w4 118 42 90 90 CD cord-302953-gr2kk9w4 118 43 DPI DPI NNP cord-302953-gr2kk9w4 118 44 ) ) -RRB- cord-302953-gr2kk9w4 118 45 of of IN cord-302953-gr2kk9w4 118 46 infection infection NN cord-302953-gr2kk9w4 118 47 . . . cord-302953-gr2kk9w4 119 1 In in IN cord-302953-gr2kk9w4 119 2 the the DT cord-302953-gr2kk9w4 119 3 CLNs cln NNS cord-302953-gr2kk9w4 119 4 , , , cord-302953-gr2kk9w4 119 5 few few JJ cord-302953-gr2kk9w4 119 6 cells cell NNS cord-302953-gr2kk9w4 119 7 produced produce VBD cord-302953-gr2kk9w4 119 8 IFN IFN NNP cord-302953-gr2kk9w4 119 9 - - HYPH cord-302953-gr2kk9w4 119 10 γ γ NNP cord-302953-gr2kk9w4 119 11 at at IN cord-302953-gr2kk9w4 119 12 any any DT cord-302953-gr2kk9w4 119 13 time time NN cord-302953-gr2kk9w4 119 14 ( ( -LRB- cord-302953-gr2kk9w4 119 15 Figure figure NN cord-302953-gr2kk9w4 119 16 3A 3a NN cord-302953-gr2kk9w4 119 17 , , , cord-302953-gr2kk9w4 119 18 C C NNP cord-302953-gr2kk9w4 119 19 ) ) -RRB- cord-302953-gr2kk9w4 119 20 . . . cord-302953-gr2kk9w4 120 1 In in IN cord-302953-gr2kk9w4 120 2 the the DT cord-302953-gr2kk9w4 120 3 brain brain NN cord-302953-gr2kk9w4 120 4 , , , cord-302953-gr2kk9w4 120 5 NK NK NNP cord-302953-gr2kk9w4 120 6 cells cell NNS cord-302953-gr2kk9w4 120 7 were be VBD cord-302953-gr2kk9w4 120 8 the the DT cord-302953-gr2kk9w4 120 9 predominant predominant JJ cord-302953-gr2kk9w4 120 10 source source NN cord-302953-gr2kk9w4 120 11 of of IN cord-302953-gr2kk9w4 120 12 IFN IFN NNP cord-302953-gr2kk9w4 120 13 - - HYPH cord-302953-gr2kk9w4 120 14 γ γ NNP cord-302953-gr2kk9w4 120 15 at at IN cord-302953-gr2kk9w4 120 16 5 5 CD cord-302953-gr2kk9w4 120 17 DPI DPI NNP cord-302953-gr2kk9w4 120 18 , , , cord-302953-gr2kk9w4 120 19 both both DT cord-302953-gr2kk9w4 120 20 as as IN cord-302953-gr2kk9w4 120 21 percentage percentage NN cord-302953-gr2kk9w4 120 22 of of IN cord-302953-gr2kk9w4 120 23 live live JJ cord-302953-gr2kk9w4 120 24 cells cell NNS cord-302953-gr2kk9w4 120 25 and and CC cord-302953-gr2kk9w4 120 26 absolute absolute JJ cord-302953-gr2kk9w4 120 27 numbers number NNS cord-302953-gr2kk9w4 120 28 ( ( -LRB- cord-302953-gr2kk9w4 120 29 Figure figure NN cord-302953-gr2kk9w4 120 30 3B 3b NN cord-302953-gr2kk9w4 120 31 , , , cord-302953-gr2kk9w4 120 32 D D NNP cord-302953-gr2kk9w4 120 33 ) ) -RRB- cord-302953-gr2kk9w4 120 34 . . . cord-302953-gr2kk9w4 121 1 Numbers number NNS cord-302953-gr2kk9w4 121 2 of of IN cord-302953-gr2kk9w4 121 3 IFN IFN NNP cord-302953-gr2kk9w4 121 4 - - HYPH cord-302953-gr2kk9w4 121 5 γ γ NNP cord-302953-gr2kk9w4 121 6 - - HYPH cord-302953-gr2kk9w4 121 7 producing produce VBG cord-302953-gr2kk9w4 121 8 cells cell NNS cord-302953-gr2kk9w4 121 9 in in IN cord-302953-gr2kk9w4 121 10 the the DT cord-302953-gr2kk9w4 121 11 brain brain NN cord-302953-gr2kk9w4 121 12 peaked peak VBD cord-302953-gr2kk9w4 121 13 at at IN cord-302953-gr2kk9w4 121 14 7 7 CD cord-302953-gr2kk9w4 121 15 DPI DPI NNP cord-302953-gr2kk9w4 121 16 and and CC cord-302953-gr2kk9w4 121 17 were be VBD cord-302953-gr2kk9w4 121 18 predominantly predominantly RB cord-302953-gr2kk9w4 121 19 CD8 CD8 NNP cord-302953-gr2kk9w4 121 20 + + CC cord-302953-gr2kk9w4 121 21 T T NNP cord-302953-gr2kk9w4 121 22 cells cell NNS cord-302953-gr2kk9w4 121 23 . . . cord-302953-gr2kk9w4 122 1 As as IN cord-302953-gr2kk9w4 122 2 CD8 CD8 NNP cord-302953-gr2kk9w4 122 3 + + CC cord-302953-gr2kk9w4 122 4 T T NNP cord-302953-gr2kk9w4 122 5 cells cell NNS cord-302953-gr2kk9w4 122 6 decreased decrease VBD cord-302953-gr2kk9w4 122 7 , , , cord-302953-gr2kk9w4 122 8 CD4 CD4 NNP cord-302953-gr2kk9w4 122 9 + + CC cord-302953-gr2kk9w4 122 10 T t NN cord-302953-gr2kk9w4 122 11 cells cell NNS cord-302953-gr2kk9w4 122 12 became become VBD cord-302953-gr2kk9w4 122 13 comparable comparable JJ cord-302953-gr2kk9w4 122 14 contributors contributor NNS cord-302953-gr2kk9w4 122 15 by by IN cord-302953-gr2kk9w4 122 16 14 14 CD cord-302953-gr2kk9w4 122 17 DPI DPI NNP cord-302953-gr2kk9w4 122 18 . . . cord-302953-gr2kk9w4 123 1 In in IN cord-302953-gr2kk9w4 123 2 Phase phase NN cord-302953-gr2kk9w4 123 3 3 3 CD cord-302953-gr2kk9w4 123 4 of of IN cord-302953-gr2kk9w4 123 5 infection infection NN cord-302953-gr2kk9w4 123 6 , , , cord-302953-gr2kk9w4 123 7 fewer few JJR cord-302953-gr2kk9w4 123 8 T t NN cord-302953-gr2kk9w4 123 9 cells cell NNS cord-302953-gr2kk9w4 123 10 were be VBD cord-302953-gr2kk9w4 123 11 present present JJ cord-302953-gr2kk9w4 123 12 in in IN cord-302953-gr2kk9w4 123 13 the the DT cord-302953-gr2kk9w4 123 14 brains brain NNS cord-302953-gr2kk9w4 123 15 and and CC cord-302953-gr2kk9w4 123 16 CD8 CD8 NNP cord-302953-gr2kk9w4 123 17 + + CC cord-302953-gr2kk9w4 123 18 and and CC cord-302953-gr2kk9w4 123 19 CD4 CD4 NNP cord-302953-gr2kk9w4 123 20 + + CC cord-302953-gr2kk9w4 123 21 T t NN cord-302953-gr2kk9w4 123 22 cells cell NNS cord-302953-gr2kk9w4 123 23 produced produce VBD cord-302953-gr2kk9w4 123 24 the the DT cord-302953-gr2kk9w4 123 25 majority majority NN cord-302953-gr2kk9w4 123 26 of of IN cord-302953-gr2kk9w4 123 27 IFN IFN NNP cord-302953-gr2kk9w4 123 28 - - HYPH cord-302953-gr2kk9w4 123 29 γ γ NNP cord-302953-gr2kk9w4 123 30 . . . cord-302953-gr2kk9w4 124 1 Therefore therefore RB cord-302953-gr2kk9w4 124 2 , , , cord-302953-gr2kk9w4 124 3 NK NK NNP cord-302953-gr2kk9w4 124 4 cells cell NNS cord-302953-gr2kk9w4 124 5 produce produce VBP cord-302953-gr2kk9w4 124 6 most most JJS cord-302953-gr2kk9w4 124 7 of of IN cord-302953-gr2kk9w4 124 8 the the DT cord-302953-gr2kk9w4 124 9 local local JJ cord-302953-gr2kk9w4 124 10 CNS CNS NNP cord-302953-gr2kk9w4 124 11 IFN IFN NNP cord-302953-gr2kk9w4 124 12 - - HYPH cord-302953-gr2kk9w4 124 13 γ γ NNP cord-302953-gr2kk9w4 124 14 early early RB cord-302953-gr2kk9w4 124 15 in in IN cord-302953-gr2kk9w4 124 16 the the DT cord-302953-gr2kk9w4 124 17 course course NN cord-302953-gr2kk9w4 124 18 of of IN cord-302953-gr2kk9w4 124 19 infection infection NN cord-302953-gr2kk9w4 124 20 , , , cord-302953-gr2kk9w4 124 21 but but CC cord-302953-gr2kk9w4 124 22 at at IN cord-302953-gr2kk9w4 124 23 later later JJ cord-302953-gr2kk9w4 124 24 times time NNS cord-302953-gr2kk9w4 124 25 , , , cord-302953-gr2kk9w4 124 26 CD4 CD4 NNP cord-302953-gr2kk9w4 124 27 + + CC cord-302953-gr2kk9w4 124 28 , , , cord-302953-gr2kk9w4 124 29 and and CC cord-302953-gr2kk9w4 124 30 especially especially RB cord-302953-gr2kk9w4 124 31 CD8 CD8 NNP cord-302953-gr2kk9w4 125 1 + + UH cord-302953-gr2kk9w4 125 2 , , , cord-302953-gr2kk9w4 125 3 T t NN cord-302953-gr2kk9w4 125 4 cells cell NNS cord-302953-gr2kk9w4 125 5 become become VBP cord-302953-gr2kk9w4 125 6 the the DT cord-302953-gr2kk9w4 125 7 predominant predominant JJ cord-302953-gr2kk9w4 125 8 source source NN cord-302953-gr2kk9w4 125 9 . . . cord-302953-gr2kk9w4 126 1 cells cell NNS cord-302953-gr2kk9w4 126 2 , , , cord-302953-gr2kk9w4 126 3 but but CC cord-302953-gr2kk9w4 126 4 not not RB cord-302953-gr2kk9w4 126 5 NK NK NNP cord-302953-gr2kk9w4 126 6 cells cell NNS cord-302953-gr2kk9w4 126 7 , , , cord-302953-gr2kk9w4 126 8 increased increase VBD cord-302953-gr2kk9w4 126 9 over over IN cord-302953-gr2kk9w4 126 10 time time NN cord-302953-gr2kk9w4 126 11 , , , cord-302953-gr2kk9w4 126 12 with with IN cord-302953-gr2kk9w4 126 13 the the DT cord-302953-gr2kk9w4 126 14 greatest great JJS cord-302953-gr2kk9w4 126 15 increase increase NN cord-302953-gr2kk9w4 126 16 occurring occur VBG cord-302953-gr2kk9w4 126 17 between between IN cord-302953-gr2kk9w4 126 18 7 7 CD cord-302953-gr2kk9w4 126 19 and and CC cord-302953-gr2kk9w4 126 20 10 10 CD cord-302953-gr2kk9w4 126 21 DPI DPI NNP cord-302953-gr2kk9w4 126 22 ( ( -LRB- cord-302953-gr2kk9w4 126 23 Figure Figure NNP cord-302953-gr2kk9w4 126 24 3H 3H NNP cord-302953-gr2kk9w4 126 25 , , , cord-302953-gr2kk9w4 126 26 J J NNP cord-302953-gr2kk9w4 126 27 ) ) -RRB- cord-302953-gr2kk9w4 126 28 . . . cord-302953-gr2kk9w4 126 29 . . . cord-302953-gr2kk9w4 127 1 Also also RB cord-302953-gr2kk9w4 127 2 evaluated evaluate VBN cord-302953-gr2kk9w4 127 3 were be VBD cord-302953-gr2kk9w4 127 4 the the DT cord-302953-gr2kk9w4 127 5 percentage percentage NN cord-302953-gr2kk9w4 127 6 of of IN cord-302953-gr2kk9w4 127 7 each each DT cord-302953-gr2kk9w4 127 8 cell cell NN cord-302953-gr2kk9w4 127 9 type type NN cord-302953-gr2kk9w4 127 10 producing produce VBG cord-302953-gr2kk9w4 127 11 IFN IFN NNP cord-302953-gr2kk9w4 127 12 - - HYPH cord-302953-gr2kk9w4 127 13 γ γ NNP cord-302953-gr2kk9w4 127 14 ( ( -LRB- cord-302953-gr2kk9w4 127 15 E E NNP cord-302953-gr2kk9w4 127 16 , , , cord-302953-gr2kk9w4 127 17 F F NNP cord-302953-gr2kk9w4 127 18 ) ) -RRB- cord-302953-gr2kk9w4 127 19 and and CC cord-302953-gr2kk9w4 127 20 the the DT cord-302953-gr2kk9w4 127 21 MFI MFI NNP cord-302953-gr2kk9w4 127 22 of of IN cord-302953-gr2kk9w4 127 23 IFN IFN NNP cord-302953-gr2kk9w4 127 24 - - HYPH cord-302953-gr2kk9w4 127 25 γ γ NNP cord-302953-gr2kk9w4 127 26 for for IN cord-302953-gr2kk9w4 127 27 each each DT cord-302953-gr2kk9w4 127 28 cell cell NN cord-302953-gr2kk9w4 127 29 type type NN cord-302953-gr2kk9w4 127 30 presented present VBN cord-302953-gr2kk9w4 127 31 in in IN cord-302953-gr2kk9w4 127 32 graph graph NN cord-302953-gr2kk9w4 127 33 form form NN cord-302953-gr2kk9w4 127 34 ( ( -LRB- cord-302953-gr2kk9w4 127 35 G g NN cord-302953-gr2kk9w4 127 36 , , , cord-302953-gr2kk9w4 127 37 H H NNP cord-302953-gr2kk9w4 127 38 ) ) -RRB- cord-302953-gr2kk9w4 127 39 and and CC cord-302953-gr2kk9w4 127 40 as as IN cord-302953-gr2kk9w4 127 41 histograms histogram NNS cord-302953-gr2kk9w4 127 42 ( ( -LRB- cord-302953-gr2kk9w4 127 43 I -PRON- PRP cord-302953-gr2kk9w4 127 44 , , , cord-302953-gr2kk9w4 127 45 J J NNP cord-302953-gr2kk9w4 127 46 ) ) -RRB- cord-302953-gr2kk9w4 127 47 ( ( -LRB- cord-302953-gr2kk9w4 127 48 n n NN cord-302953-gr2kk9w4 127 49 = = SYM cord-302953-gr2kk9w4 127 50 3 3 CD cord-302953-gr2kk9w4 127 51 - - SYM cord-302953-gr2kk9w4 127 52 7 7 CD cord-302953-gr2kk9w4 127 53 pooled pool VBN cord-302953-gr2kk9w4 127 54 mice mouse NNS cord-302953-gr2kk9w4 127 55 per per IN cord-302953-gr2kk9w4 127 56 time time NN cord-302953-gr2kk9w4 127 57 point point NN cord-302953-gr2kk9w4 127 58 from from IN cord-302953-gr2kk9w4 127 59 three three CD cord-302953-gr2kk9w4 127 60 independent independent JJ cord-302953-gr2kk9w4 127 61 experiments experiment NNS cord-302953-gr2kk9w4 127 62 , , , cord-302953-gr2kk9w4 127 63 except except IN cord-302953-gr2kk9w4 127 64 for for IN cord-302953-gr2kk9w4 127 65 data datum NNS cord-302953-gr2kk9w4 127 66 from from IN cord-302953-gr2kk9w4 127 67 5 5 CD cord-302953-gr2kk9w4 127 68 DPI DPI NNP cord-302953-gr2kk9w4 127 69 CLNs cln NNS cord-302953-gr2kk9w4 127 70 , , , cord-302953-gr2kk9w4 127 71 which which WDT cord-302953-gr2kk9w4 127 72 were be VBD cord-302953-gr2kk9w4 127 73 from from IN cord-302953-gr2kk9w4 127 74 two two CD cord-302953-gr2kk9w4 127 75 independent independent JJ cord-302953-gr2kk9w4 127 76 experiments experiment NNS cord-302953-gr2kk9w4 127 77 ; ; : cord-302953-gr2kk9w4 127 78 data datum NNS cord-302953-gr2kk9w4 127 79 are be VBP cord-302953-gr2kk9w4 127 80 presented present VBN cord-302953-gr2kk9w4 127 81 as as IN cord-302953-gr2kk9w4 127 82 the the DT cord-302953-gr2kk9w4 127 83 mean mean JJ cord-302953-gr2kk9w4 127 84 ± ± NNP cord-302953-gr2kk9w4 127 85 SEM SEM NNP cord-302953-gr2kk9w4 127 86 ) ) -RRB- cord-302953-gr2kk9w4 127 87 . . . cord-302953-gr2kk9w4 128 1 To to TO cord-302953-gr2kk9w4 128 2 determine determine VB cord-302953-gr2kk9w4 128 3 the the DT cord-302953-gr2kk9w4 128 4 in in IN cord-302953-gr2kk9w4 128 5 vivo vivo NN cord-302953-gr2kk9w4 128 6 role role NN cord-302953-gr2kk9w4 128 7 of of IN cord-302953-gr2kk9w4 128 8 IFN IFN NNP cord-302953-gr2kk9w4 128 9 - - HYPH cord-302953-gr2kk9w4 128 10 γ γ NNP cord-302953-gr2kk9w4 128 11 during during IN cord-302953-gr2kk9w4 128 12 SINV SINV NNP cord-302953-gr2kk9w4 128 13 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 128 14 , , , cord-302953-gr2kk9w4 128 15 the the DT cord-302953-gr2kk9w4 128 16 responses response NNS cord-302953-gr2kk9w4 128 17 of of IN cord-302953-gr2kk9w4 128 18 mice mouse NNS cord-302953-gr2kk9w4 128 19 deficient deficient JJ cord-302953-gr2kk9w4 128 20 in in IN cord-302953-gr2kk9w4 128 21 IFN IFN NNP cord-302953-gr2kk9w4 128 22 - - HYPH cord-302953-gr2kk9w4 128 23 γ γ NNP cord-302953-gr2kk9w4 128 24 ( ( -LRB- cord-302953-gr2kk9w4 128 25 Ifng Ifng NNP cord-302953-gr2kk9w4 128 26 −/− −/− NNP cord-302953-gr2kk9w4 128 27 ) ) -RRB- cord-302953-gr2kk9w4 128 28 or or CC cord-302953-gr2kk9w4 128 29 in in IN cord-302953-gr2kk9w4 128 30 the the DT cord-302953-gr2kk9w4 128 31 α α NN cord-302953-gr2kk9w4 128 32 - - HYPH cord-302953-gr2kk9w4 128 33 chain chain NN cord-302953-gr2kk9w4 128 34 of of IN cord-302953-gr2kk9w4 128 35 the the DT cord-302953-gr2kk9w4 128 36 IFN IFN NNP cord-302953-gr2kk9w4 128 37 - - HYPH cord-302953-gr2kk9w4 128 38 γ γ NN cord-302953-gr2kk9w4 128 39 receptor receptor NN cord-302953-gr2kk9w4 128 40 ( ( -LRB- cord-302953-gr2kk9w4 128 41 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 128 42 −/− −/− NNP cord-302953-gr2kk9w4 128 43 ) ) -RRB- cord-302953-gr2kk9w4 128 44 were be VBD cord-302953-gr2kk9w4 128 45 compared compare VBN cord-302953-gr2kk9w4 128 46 to to IN cord-302953-gr2kk9w4 128 47 those those DT cord-302953-gr2kk9w4 128 48 of of IN cord-302953-gr2kk9w4 128 49 WT WT NNP cord-302953-gr2kk9w4 128 50 mice mouse NNS cord-302953-gr2kk9w4 128 51 . . . cord-302953-gr2kk9w4 129 1 To to TO cord-302953-gr2kk9w4 129 2 assess assess VB cord-302953-gr2kk9w4 129 3 expression expression NN cord-302953-gr2kk9w4 129 4 of of IN cord-302953-gr2kk9w4 129 5 antiviral antiviral JJ cord-302953-gr2kk9w4 129 6 ISG ISG NNP cord-302953-gr2kk9w4 129 7 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 129 8 for for IN cord-302953-gr2kk9w4 129 9 the the DT cord-302953-gr2kk9w4 129 10 five five CD cord-302953-gr2kk9w4 129 11 antiviral antiviral JJ cord-302953-gr2kk9w4 129 12 ISGs ISGs NNPS cord-302953-gr2kk9w4 129 13 previously previously RB cord-302953-gr2kk9w4 129 14 selected select VBN cord-302953-gr2kk9w4 129 15 for for IN cord-302953-gr2kk9w4 129 16 in in FW cord-302953-gr2kk9w4 129 17 vitro vitro FW cord-302953-gr2kk9w4 129 18 analysis analysis NN cord-302953-gr2kk9w4 129 19 of of IN cord-302953-gr2kk9w4 129 20 neuronal neuronal JJ cord-302953-gr2kk9w4 129 21 responses response NNS cord-302953-gr2kk9w4 129 22 plus plus CC cord-302953-gr2kk9w4 129 23 Oas1a oas1a IN cord-302953-gr2kk9w4 129 24 , , , cord-302953-gr2kk9w4 129 25 a a DT cord-302953-gr2kk9w4 129 26 protein protein NN cord-302953-gr2kk9w4 129 27 associated associate VBN cord-302953-gr2kk9w4 129 28 with with IN cord-302953-gr2kk9w4 129 29 the the DT cord-302953-gr2kk9w4 129 30 2'-5'oligoadenylate 2'-5'oligoadenylate CD cord-302953-gr2kk9w4 129 31 / / SYM cord-302953-gr2kk9w4 129 32 RNase rnase NN cord-302953-gr2kk9w4 129 33 L l NN cord-302953-gr2kk9w4 129 34 system system NN cord-302953-gr2kk9w4 129 35 that that WDT cord-302953-gr2kk9w4 129 36 is be VBZ cord-302953-gr2kk9w4 129 37 more more RBR cord-302953-gr2kk9w4 129 38 active active JJ cord-302953-gr2kk9w4 129 39 than than IN cord-302953-gr2kk9w4 129 40 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 130 1 in in IN cord-302953-gr2kk9w4 130 2 mice mouse NNS cord-302953-gr2kk9w4 130 3 [ [ -LRB- cord-302953-gr2kk9w4 130 4 26 26 CD cord-302953-gr2kk9w4 130 5 ] ] -RRB- cord-302953-gr2kk9w4 130 6 were be VBD cord-302953-gr2kk9w4 130 7 examined examine VBN cord-302953-gr2kk9w4 130 8 by by IN cord-302953-gr2kk9w4 130 9 qRT qRT NNP cord-302953-gr2kk9w4 130 10 - - HYPH cord-302953-gr2kk9w4 130 11 PCR PCR NNP cord-302953-gr2kk9w4 130 12 ( ( -LRB- cord-302953-gr2kk9w4 130 13 Figure Figure NNP cord-302953-gr2kk9w4 130 14 4 4 CD cord-302953-gr2kk9w4 130 15 ) ) -RRB- cord-302953-gr2kk9w4 130 16 . . . cord-302953-gr2kk9w4 131 1 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 131 2 , , , cord-302953-gr2kk9w4 131 3 Irgm1 irgm1 UH cord-302953-gr2kk9w4 131 4 , , , cord-302953-gr2kk9w4 131 5 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 131 6 , , , cord-302953-gr2kk9w4 131 7 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 131 8 , , , cord-302953-gr2kk9w4 131 9 and and CC cord-302953-gr2kk9w4 131 10 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 131 11 were be VBD cord-302953-gr2kk9w4 131 12 up up RB cord-302953-gr2kk9w4 131 13 regulated regulate VBN cord-302953-gr2kk9w4 131 14 in in IN cord-302953-gr2kk9w4 131 15 the the DT cord-302953-gr2kk9w4 131 16 brains brain NNS cord-302953-gr2kk9w4 131 17 and and CC cord-302953-gr2kk9w4 131 18 spinal spinal JJ cord-302953-gr2kk9w4 131 19 cords cord NNS cord-302953-gr2kk9w4 131 20 of of IN cord-302953-gr2kk9w4 131 21 all all DT cord-302953-gr2kk9w4 131 22 mice mouse NNS cord-302953-gr2kk9w4 131 23 during during IN cord-302953-gr2kk9w4 131 24 SINV SINV NNP cord-302953-gr2kk9w4 131 25 infection infection NN cord-302953-gr2kk9w4 131 26 , , , cord-302953-gr2kk9w4 131 27 likely likely RB cord-302953-gr2kk9w4 131 28 reflecting reflect VBG cord-302953-gr2kk9w4 131 29 the the DT cord-302953-gr2kk9w4 131 30 overlap overlap NN cord-302953-gr2kk9w4 131 31 with with IN cord-302953-gr2kk9w4 131 32 ISGs isg NNS cord-302953-gr2kk9w4 131 33 induced induce VBN cord-302953-gr2kk9w4 131 34 by by IN cord-302953-gr2kk9w4 131 35 type type NN cord-302953-gr2kk9w4 131 36 I -PRON- PRP cord-302953-gr2kk9w4 131 37 IFN IFN NNP cord-302953-gr2kk9w4 131 38 . . . cord-302953-gr2kk9w4 132 1 However however RB cord-302953-gr2kk9w4 132 2 , , , cord-302953-gr2kk9w4 132 3 expression expression NN cord-302953-gr2kk9w4 132 4 of of IN cord-302953-gr2kk9w4 132 5 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 132 6 ( ( -LRB- cord-302953-gr2kk9w4 132 7 Figure figure NN cord-302953-gr2kk9w4 132 8 4A 4a CD cord-302953-gr2kk9w4 132 9 ) ) -RRB- cord-302953-gr2kk9w4 132 10 and and CC cord-302953-gr2kk9w4 132 11 Irgm1 irgm1 FW cord-302953-gr2kk9w4 132 12 ( ( -LRB- cord-302953-gr2kk9w4 132 13 Figure figure NN cord-302953-gr2kk9w4 132 14 4B 4b CD cord-302953-gr2kk9w4 132 15 ) ) -RRB- cord-302953-gr2kk9w4 132 16 at at IN cord-302953-gr2kk9w4 132 17 5 5 CD cord-302953-gr2kk9w4 132 18 - - SYM cord-302953-gr2kk9w4 132 19 10 10 CD cord-302953-gr2kk9w4 132 20 DPI DPI NNP cord-302953-gr2kk9w4 132 21 in in IN cord-302953-gr2kk9w4 132 22 the the DT cord-302953-gr2kk9w4 132 23 brain brain NN cord-302953-gr2kk9w4 132 24 and and CC cord-302953-gr2kk9w4 132 25 spinal spinal NN cord-302953-gr2kk9w4 132 26 . . . cord-302953-gr2kk9w4 133 1 Also also RB cord-302953-gr2kk9w4 133 2 evaluated evaluate VBN cord-302953-gr2kk9w4 133 3 were be VBD cord-302953-gr2kk9w4 133 4 the the DT cord-302953-gr2kk9w4 133 5 percentage percentage NN cord-302953-gr2kk9w4 133 6 of of IN cord-302953-gr2kk9w4 133 7 each each DT cord-302953-gr2kk9w4 133 8 cell cell NN cord-302953-gr2kk9w4 133 9 type type NN cord-302953-gr2kk9w4 133 10 producing produce VBG cord-302953-gr2kk9w4 133 11 IFN IFN NNP cord-302953-gr2kk9w4 133 12 - - HYPH cord-302953-gr2kk9w4 133 13 γ γ NNP cord-302953-gr2kk9w4 133 14 ( ( -LRB- cord-302953-gr2kk9w4 133 15 E E NNP cord-302953-gr2kk9w4 133 16 , , , cord-302953-gr2kk9w4 133 17 F F NNP cord-302953-gr2kk9w4 133 18 ) ) -RRB- cord-302953-gr2kk9w4 133 19 and and CC cord-302953-gr2kk9w4 133 20 the the DT cord-302953-gr2kk9w4 133 21 MFI MFI NNP cord-302953-gr2kk9w4 133 22 of of IN cord-302953-gr2kk9w4 133 23 IFN IFN NNP cord-302953-gr2kk9w4 133 24 - - HYPH cord-302953-gr2kk9w4 133 25 γ γ NNP cord-302953-gr2kk9w4 133 26 for for IN cord-302953-gr2kk9w4 133 27 each each DT cord-302953-gr2kk9w4 133 28 cell cell NN cord-302953-gr2kk9w4 133 29 type type NN cord-302953-gr2kk9w4 133 30 presented present VBN cord-302953-gr2kk9w4 133 31 in in IN cord-302953-gr2kk9w4 133 32 graph graph NN cord-302953-gr2kk9w4 133 33 form form NN cord-302953-gr2kk9w4 133 34 ( ( -LRB- cord-302953-gr2kk9w4 133 35 G g NN cord-302953-gr2kk9w4 133 36 , , , cord-302953-gr2kk9w4 133 37 H H NNP cord-302953-gr2kk9w4 133 38 ) ) -RRB- cord-302953-gr2kk9w4 133 39 and and CC cord-302953-gr2kk9w4 133 40 as as IN cord-302953-gr2kk9w4 133 41 histograms histogram NNS cord-302953-gr2kk9w4 133 42 ( ( -LRB- cord-302953-gr2kk9w4 133 43 I -PRON- PRP cord-302953-gr2kk9w4 133 44 , , , cord-302953-gr2kk9w4 133 45 J J NNP cord-302953-gr2kk9w4 133 46 ) ) -RRB- cord-302953-gr2kk9w4 133 47 ( ( -LRB- cord-302953-gr2kk9w4 133 48 n n NN cord-302953-gr2kk9w4 133 49 = = SYM cord-302953-gr2kk9w4 133 50 3 3 CD cord-302953-gr2kk9w4 133 51 - - SYM cord-302953-gr2kk9w4 133 52 7 7 CD cord-302953-gr2kk9w4 133 53 pooled pool VBN cord-302953-gr2kk9w4 133 54 mice mouse NNS cord-302953-gr2kk9w4 133 55 per per IN cord-302953-gr2kk9w4 133 56 time time NN cord-302953-gr2kk9w4 133 57 point point NN cord-302953-gr2kk9w4 133 58 from from IN cord-302953-gr2kk9w4 133 59 three three CD cord-302953-gr2kk9w4 133 60 independent independent JJ cord-302953-gr2kk9w4 133 61 experiments experiment NNS cord-302953-gr2kk9w4 133 62 , , , cord-302953-gr2kk9w4 133 63 except except IN cord-302953-gr2kk9w4 133 64 for for IN cord-302953-gr2kk9w4 133 65 data datum NNS cord-302953-gr2kk9w4 133 66 from from IN cord-302953-gr2kk9w4 133 67 5 5 CD cord-302953-gr2kk9w4 133 68 DPI DPI NNP cord-302953-gr2kk9w4 133 69 CLNs cln NNS cord-302953-gr2kk9w4 133 70 , , , cord-302953-gr2kk9w4 133 71 which which WDT cord-302953-gr2kk9w4 133 72 were be VBD cord-302953-gr2kk9w4 133 73 from from IN cord-302953-gr2kk9w4 133 74 two two CD cord-302953-gr2kk9w4 133 75 independent independent JJ cord-302953-gr2kk9w4 133 76 experiments experiment NNS cord-302953-gr2kk9w4 133 77 ; ; : cord-302953-gr2kk9w4 133 78 data datum NNS cord-302953-gr2kk9w4 133 79 are be VBP cord-302953-gr2kk9w4 133 80 presented present VBN cord-302953-gr2kk9w4 133 81 as as IN cord-302953-gr2kk9w4 133 82 the the DT cord-302953-gr2kk9w4 133 83 mean mean JJ cord-302953-gr2kk9w4 133 84 ± ± NNP cord-302953-gr2kk9w4 133 85 SEM SEM NNP cord-302953-gr2kk9w4 133 86 ) ) -RRB- cord-302953-gr2kk9w4 133 87 . . . cord-302953-gr2kk9w4 134 1 We -PRON- PRP cord-302953-gr2kk9w4 134 2 next next RB cord-302953-gr2kk9w4 134 3 characterized characterize VBD cord-302953-gr2kk9w4 134 4 the the DT cord-302953-gr2kk9w4 134 5 percentages percentage NNS cord-302953-gr2kk9w4 134 6 of of IN cord-302953-gr2kk9w4 134 7 each each DT cord-302953-gr2kk9w4 134 8 cell cell NN cord-302953-gr2kk9w4 134 9 population population NN cord-302953-gr2kk9w4 134 10 producing produce VBG cord-302953-gr2kk9w4 134 11 IFN IFN NNP cord-302953-gr2kk9w4 134 12 - - HYPH cord-302953-gr2kk9w4 134 13 γ γ NNP cord-302953-gr2kk9w4 134 14 . . . cord-302953-gr2kk9w4 135 1 Little little JJ cord-302953-gr2kk9w4 135 2 change change NN cord-302953-gr2kk9w4 135 3 was be VBD cord-302953-gr2kk9w4 135 4 seen see VBN cord-302953-gr2kk9w4 135 5 in in IN cord-302953-gr2kk9w4 135 6 the the DT cord-302953-gr2kk9w4 135 7 CLNs cln NNS cord-302953-gr2kk9w4 135 8 , , , cord-302953-gr2kk9w4 135 9 with with IN cord-302953-gr2kk9w4 135 10 less less JJR cord-302953-gr2kk9w4 135 11 than than IN cord-302953-gr2kk9w4 135 12 10 10 CD cord-302953-gr2kk9w4 135 13 % % NN cord-302953-gr2kk9w4 135 14 of of IN cord-302953-gr2kk9w4 135 15 CD4 CD4 NNP cord-302953-gr2kk9w4 135 16 + + CC cord-302953-gr2kk9w4 135 17 T t NN cord-302953-gr2kk9w4 135 18 cells cell NNS cord-302953-gr2kk9w4 135 19 , , , cord-302953-gr2kk9w4 135 20 less less JJR cord-302953-gr2kk9w4 135 21 than than IN cord-302953-gr2kk9w4 135 22 20 20 CD cord-302953-gr2kk9w4 135 23 % % NN cord-302953-gr2kk9w4 135 24 of of IN cord-302953-gr2kk9w4 135 25 CD8 CD8 NNP cord-302953-gr2kk9w4 135 26 + + CC cord-302953-gr2kk9w4 135 27 T T NNP cord-302953-gr2kk9w4 135 28 cells cell NNS cord-302953-gr2kk9w4 135 29 , , , cord-302953-gr2kk9w4 135 30 and and CC cord-302953-gr2kk9w4 135 31 20 20 CD cord-302953-gr2kk9w4 135 32 - - SYM cord-302953-gr2kk9w4 135 33 40 40 CD cord-302953-gr2kk9w4 135 34 % % NN cord-302953-gr2kk9w4 135 35 of of IN cord-302953-gr2kk9w4 135 36 NK NK NNP cord-302953-gr2kk9w4 135 37 cells cell NNS cord-302953-gr2kk9w4 135 38 producing produce VBG cord-302953-gr2kk9w4 135 39 IFN IFN NNP cord-302953-gr2kk9w4 135 40 - - HYPH cord-302953-gr2kk9w4 135 41 γ γ NN cord-302953-gr2kk9w4 135 42 at at IN cord-302953-gr2kk9w4 135 43 any any DT cord-302953-gr2kk9w4 135 44 time time NN cord-302953-gr2kk9w4 135 45 after after IN cord-302953-gr2kk9w4 135 46 infection infection NN cord-302953-gr2kk9w4 135 47 ( ( -LRB- cord-302953-gr2kk9w4 135 48 Figure Figure NNP cord-302953-gr2kk9w4 135 49 3E 3e NN cord-302953-gr2kk9w4 135 50 ) ) -RRB- cord-302953-gr2kk9w4 135 51 . . . cord-302953-gr2kk9w4 136 1 In in IN cord-302953-gr2kk9w4 136 2 the the DT cord-302953-gr2kk9w4 136 3 brain brain NN cord-302953-gr2kk9w4 136 4 , , , cord-302953-gr2kk9w4 136 5 the the DT cord-302953-gr2kk9w4 136 6 percentage percentage NN cord-302953-gr2kk9w4 136 7 of of IN cord-302953-gr2kk9w4 136 8 CD4 CD4 NNP cord-302953-gr2kk9w4 136 9 + + CC cord-302953-gr2kk9w4 136 10 and and CC cord-302953-gr2kk9w4 136 11 CD8 CD8 NNP cord-302953-gr2kk9w4 136 12 + + CC cord-302953-gr2kk9w4 136 13 T T NNP cord-302953-gr2kk9w4 136 14 cells cell NNS cord-302953-gr2kk9w4 136 15 producing produce VBG cord-302953-gr2kk9w4 136 16 IFN IFN NNP cord-302953-gr2kk9w4 136 17 - - HYPH cord-302953-gr2kk9w4 136 18 γ γ NNP cord-302953-gr2kk9w4 136 19 increased increase VBD cord-302953-gr2kk9w4 136 20 over over IN cord-302953-gr2kk9w4 136 21 the the DT cord-302953-gr2kk9w4 136 22 course course NN cord-302953-gr2kk9w4 136 23 of of IN cord-302953-gr2kk9w4 136 24 infection infection NN cord-302953-gr2kk9w4 136 25 , , , cord-302953-gr2kk9w4 136 26 going go VBG cord-302953-gr2kk9w4 136 27 from from IN cord-302953-gr2kk9w4 136 28 approximately approximately RB cord-302953-gr2kk9w4 136 29 40 40 CD cord-302953-gr2kk9w4 136 30 to to TO cord-302953-gr2kk9w4 136 31 60 60 CD cord-302953-gr2kk9w4 136 32 % % NN cord-302953-gr2kk9w4 136 33 at at IN cord-302953-gr2kk9w4 136 34 5 5 CD cord-302953-gr2kk9w4 136 35 and and CC cord-302953-gr2kk9w4 136 36 7 7 CD cord-302953-gr2kk9w4 136 37 DPI DPI NNP cord-302953-gr2kk9w4 136 38 to to IN cord-302953-gr2kk9w4 136 39 over over IN cord-302953-gr2kk9w4 136 40 80 80 CD cord-302953-gr2kk9w4 136 41 % % NN cord-302953-gr2kk9w4 136 42 at at IN cord-302953-gr2kk9w4 136 43 10 10 CD cord-302953-gr2kk9w4 136 44 , , , cord-302953-gr2kk9w4 136 45 14 14 CD cord-302953-gr2kk9w4 136 46 , , , cord-302953-gr2kk9w4 136 47 and and CC cord-302953-gr2kk9w4 136 48 90 90 CD cord-302953-gr2kk9w4 136 49 DPI DPI NNP cord-302953-gr2kk9w4 136 50 ( ( -LRB- cord-302953-gr2kk9w4 136 51 Figure Figure NNP cord-302953-gr2kk9w4 136 52 3F 3F NNP cord-302953-gr2kk9w4 136 53 ) ) -RRB- cord-302953-gr2kk9w4 136 54 . . . cord-302953-gr2kk9w4 137 1 In in IN cord-302953-gr2kk9w4 137 2 contrast contrast NN cord-302953-gr2kk9w4 137 3 , , , cord-302953-gr2kk9w4 137 4 the the DT cord-302953-gr2kk9w4 137 5 percentage percentage NN cord-302953-gr2kk9w4 137 6 of of IN cord-302953-gr2kk9w4 137 7 brain brain NN cord-302953-gr2kk9w4 137 8 NK NK NNP cord-302953-gr2kk9w4 137 9 cells cell NNS cord-302953-gr2kk9w4 137 10 producing produce VBG cord-302953-gr2kk9w4 137 11 IFN IFN NNP cord-302953-gr2kk9w4 137 12 - - HYPH cord-302953-gr2kk9w4 137 13 γ γ NNP cord-302953-gr2kk9w4 137 14 remained remain VBD cord-302953-gr2kk9w4 137 15 between between IN cord-302953-gr2kk9w4 137 16 20 20 CD cord-302953-gr2kk9w4 137 17 to to TO cord-302953-gr2kk9w4 137 18 50 50 CD cord-302953-gr2kk9w4 137 19 % % NN cord-302953-gr2kk9w4 137 20 , , , cord-302953-gr2kk9w4 137 21 similar similar JJ cord-302953-gr2kk9w4 137 22 to to IN cord-302953-gr2kk9w4 137 23 that that DT cord-302953-gr2kk9w4 137 24 in in IN cord-302953-gr2kk9w4 137 25 the the DT cord-302953-gr2kk9w4 137 26 CLNs cln NNS cord-302953-gr2kk9w4 137 27 . . . cord-302953-gr2kk9w4 138 1 To to TO cord-302953-gr2kk9w4 138 2 compare compare VB cord-302953-gr2kk9w4 138 3 the the DT cord-302953-gr2kk9w4 138 4 relative relative JJ cord-302953-gr2kk9w4 138 5 amounts amount NNS cord-302953-gr2kk9w4 138 6 of of IN cord-302953-gr2kk9w4 138 7 IFN IFN NNP cord-302953-gr2kk9w4 138 8 - - HYPH cord-302953-gr2kk9w4 138 9 γ γ NNP cord-302953-gr2kk9w4 138 10 produced produce VBN cord-302953-gr2kk9w4 138 11 by by IN cord-302953-gr2kk9w4 138 12 each each DT cord-302953-gr2kk9w4 138 13 cell cell NN cord-302953-gr2kk9w4 138 14 type type NN cord-302953-gr2kk9w4 138 15 , , , cord-302953-gr2kk9w4 138 16 median median JJ cord-302953-gr2kk9w4 138 17 fluorescence fluorescence NN cord-302953-gr2kk9w4 138 18 intensities intensity NNS cord-302953-gr2kk9w4 138 19 ( ( -LRB- cord-302953-gr2kk9w4 138 20 MFIs mfi NNS cord-302953-gr2kk9w4 138 21 ) ) -RRB- cord-302953-gr2kk9w4 138 22 were be VBD cord-302953-gr2kk9w4 138 23 determined determine VBN cord-302953-gr2kk9w4 138 24 . . . cord-302953-gr2kk9w4 139 1 In in IN cord-302953-gr2kk9w4 139 2 the the DT cord-302953-gr2kk9w4 139 3 CLNs cln NNS cord-302953-gr2kk9w4 139 4 , , , cord-302953-gr2kk9w4 139 5 the the DT cord-302953-gr2kk9w4 139 6 MFI MFI NNP cord-302953-gr2kk9w4 139 7 for for IN cord-302953-gr2kk9w4 139 8 IFN IFN NNP cord-302953-gr2kk9w4 139 9 - - HYPH cord-302953-gr2kk9w4 139 10 γ γ NNP cord-302953-gr2kk9w4 139 11 remained remain VBD cord-302953-gr2kk9w4 139 12 low low JJ cord-302953-gr2kk9w4 139 13 and and CC cord-302953-gr2kk9w4 139 14 did do VBD cord-302953-gr2kk9w4 139 15 not not RB cord-302953-gr2kk9w4 139 16 change change VB cord-302953-gr2kk9w4 139 17 for for IN cord-302953-gr2kk9w4 139 18 any any DT cord-302953-gr2kk9w4 139 19 cell cell NN cord-302953-gr2kk9w4 139 20 population population NN cord-302953-gr2kk9w4 139 21 ( ( -LRB- cord-302953-gr2kk9w4 139 22 Figure figure NN cord-302953-gr2kk9w4 139 23 3 3 CD cord-302953-gr2kk9w4 139 24 G g NN cord-302953-gr2kk9w4 139 25 , , , cord-302953-gr2kk9w4 139 26 I -PRON- PRP cord-302953-gr2kk9w4 139 27 ) ) -RRB- cord-302953-gr2kk9w4 139 28 . . . cord-302953-gr2kk9w4 140 1 However however RB cord-302953-gr2kk9w4 140 2 , , , cord-302953-gr2kk9w4 140 3 in in IN cord-302953-gr2kk9w4 140 4 the the DT cord-302953-gr2kk9w4 140 5 brain brain NN cord-302953-gr2kk9w4 140 6 , , , cord-302953-gr2kk9w4 140 7 the the DT cord-302953-gr2kk9w4 140 8 IFN IFN NNP cord-302953-gr2kk9w4 140 9 - - HYPH cord-302953-gr2kk9w4 140 10 γ γ NNP cord-302953-gr2kk9w4 140 11 MFIs mfi NNS cord-302953-gr2kk9w4 140 12 for for IN cord-302953-gr2kk9w4 140 13 CD4 CD4 NNP cord-302953-gr2kk9w4 140 14 + + CC cord-302953-gr2kk9w4 140 15 and and CC cord-302953-gr2kk9w4 140 16 CD8 CD8 NNP cord-302953-gr2kk9w4 140 17 + + CC cord-302953-gr2kk9w4 140 18 T T NNP cord-302953-gr2kk9w4 140 19 cells cell NNS cord-302953-gr2kk9w4 140 20 , , , cord-302953-gr2kk9w4 140 21 but but CC cord-302953-gr2kk9w4 140 22 not not RB cord-302953-gr2kk9w4 140 23 NK NK NNP cord-302953-gr2kk9w4 140 24 cells cell NNS cord-302953-gr2kk9w4 140 25 , , , cord-302953-gr2kk9w4 140 26 increased increase VBD cord-302953-gr2kk9w4 140 27 over over IN cord-302953-gr2kk9w4 140 28 time time NN cord-302953-gr2kk9w4 140 29 , , , cord-302953-gr2kk9w4 140 30 with with IN cord-302953-gr2kk9w4 140 31 the the DT cord-302953-gr2kk9w4 140 32 greatest great JJS cord-302953-gr2kk9w4 140 33 increase increase NN cord-302953-gr2kk9w4 140 34 occurring occur VBG cord-302953-gr2kk9w4 140 35 between between IN cord-302953-gr2kk9w4 140 36 7 7 CD cord-302953-gr2kk9w4 140 37 and and CC cord-302953-gr2kk9w4 140 38 10 10 CD cord-302953-gr2kk9w4 140 39 DPI DPI NNP cord-302953-gr2kk9w4 140 40 ( ( -LRB- cord-302953-gr2kk9w4 140 41 Figure Figure NNP cord-302953-gr2kk9w4 140 42 3H 3H NNP cord-302953-gr2kk9w4 140 43 , , , cord-302953-gr2kk9w4 140 44 J J NNP cord-302953-gr2kk9w4 140 45 ) ) -RRB- cord-302953-gr2kk9w4 140 46 . . . cord-302953-gr2kk9w4 140 47 _SP cord-302953-gr2kk9w4 141 1 To to TO cord-302953-gr2kk9w4 141 2 determine determine VB cord-302953-gr2kk9w4 141 3 the the DT cord-302953-gr2kk9w4 141 4 in in IN cord-302953-gr2kk9w4 141 5 vivo vivo NN cord-302953-gr2kk9w4 141 6 role role NN cord-302953-gr2kk9w4 141 7 of of IN cord-302953-gr2kk9w4 141 8 IFN IFN NNP cord-302953-gr2kk9w4 141 9 - - HYPH cord-302953-gr2kk9w4 141 10 γ γ NNP cord-302953-gr2kk9w4 141 11 during during IN cord-302953-gr2kk9w4 141 12 SINV SINV NNP cord-302953-gr2kk9w4 141 13 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 141 14 , , , cord-302953-gr2kk9w4 141 15 the the DT cord-302953-gr2kk9w4 141 16 responses response NNS cord-302953-gr2kk9w4 141 17 of of IN cord-302953-gr2kk9w4 141 18 mice mouse NNS cord-302953-gr2kk9w4 141 19 deficient deficient JJ cord-302953-gr2kk9w4 141 20 in in IN cord-302953-gr2kk9w4 141 21 IFN IFN NNP cord-302953-gr2kk9w4 141 22 - - HYPH cord-302953-gr2kk9w4 141 23 γ γ NNP cord-302953-gr2kk9w4 141 24 ( ( -LRB- cord-302953-gr2kk9w4 141 25 Ifng Ifng NNP cord-302953-gr2kk9w4 141 26 −/− −/− NNP cord-302953-gr2kk9w4 141 27 ) ) -RRB- cord-302953-gr2kk9w4 141 28 or or CC cord-302953-gr2kk9w4 141 29 in in IN cord-302953-gr2kk9w4 141 30 the the DT cord-302953-gr2kk9w4 141 31 α α NN cord-302953-gr2kk9w4 141 32 - - HYPH cord-302953-gr2kk9w4 141 33 chain chain NN cord-302953-gr2kk9w4 141 34 of of IN cord-302953-gr2kk9w4 141 35 the the DT cord-302953-gr2kk9w4 141 36 IFN IFN NNP cord-302953-gr2kk9w4 141 37 - - HYPH cord-302953-gr2kk9w4 141 38 γ γ NN cord-302953-gr2kk9w4 141 39 receptor receptor NN cord-302953-gr2kk9w4 141 40 ( ( -LRB- cord-302953-gr2kk9w4 141 41 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 141 42 −/− −/− NNP cord-302953-gr2kk9w4 141 43 ) ) -RRB- cord-302953-gr2kk9w4 141 44 were be VBD cord-302953-gr2kk9w4 141 45 compared compare VBN cord-302953-gr2kk9w4 141 46 to to IN cord-302953-gr2kk9w4 141 47 those those DT cord-302953-gr2kk9w4 141 48 of of IN cord-302953-gr2kk9w4 141 49 WT WT NNP cord-302953-gr2kk9w4 141 50 mice mouse NNS cord-302953-gr2kk9w4 141 51 . . . cord-302953-gr2kk9w4 142 1 To to TO cord-302953-gr2kk9w4 142 2 assess assess VB cord-302953-gr2kk9w4 142 3 expression expression NN cord-302953-gr2kk9w4 142 4 of of IN cord-302953-gr2kk9w4 142 5 antiviral antiviral JJ cord-302953-gr2kk9w4 142 6 ISG ISG NNP cord-302953-gr2kk9w4 142 7 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 142 8 for for IN cord-302953-gr2kk9w4 142 9 the the DT cord-302953-gr2kk9w4 142 10 five five CD cord-302953-gr2kk9w4 142 11 antiviral antiviral JJ cord-302953-gr2kk9w4 142 12 ISGs ISGs NNPS cord-302953-gr2kk9w4 142 13 previously previously RB cord-302953-gr2kk9w4 142 14 selected select VBN cord-302953-gr2kk9w4 142 15 for for IN cord-302953-gr2kk9w4 142 16 in in FW cord-302953-gr2kk9w4 142 17 vitro vitro FW cord-302953-gr2kk9w4 142 18 analysis analysis NN cord-302953-gr2kk9w4 142 19 of of IN cord-302953-gr2kk9w4 142 20 neuronal neuronal JJ cord-302953-gr2kk9w4 142 21 responses response NNS cord-302953-gr2kk9w4 142 22 plus plus CC cord-302953-gr2kk9w4 142 23 Oas1a oas1a IN cord-302953-gr2kk9w4 142 24 , , , cord-302953-gr2kk9w4 142 25 a a DT cord-302953-gr2kk9w4 142 26 protein protein NN cord-302953-gr2kk9w4 142 27 associated associate VBN cord-302953-gr2kk9w4 142 28 with with IN cord-302953-gr2kk9w4 142 29 the the DT cord-302953-gr2kk9w4 142 30 2'-5'oligoadenylate 2'-5'oligoadenylate CD cord-302953-gr2kk9w4 142 31 / / SYM cord-302953-gr2kk9w4 142 32 RNase rnase NN cord-302953-gr2kk9w4 142 33 L l NN cord-302953-gr2kk9w4 142 34 system system NN cord-302953-gr2kk9w4 142 35 that that WDT cord-302953-gr2kk9w4 142 36 is be VBZ cord-302953-gr2kk9w4 142 37 more more RBR cord-302953-gr2kk9w4 142 38 active active JJ cord-302953-gr2kk9w4 142 39 than than IN cord-302953-gr2kk9w4 142 40 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 143 1 in in IN cord-302953-gr2kk9w4 143 2 mice mouse NNS cord-302953-gr2kk9w4 143 3 [ [ -LRB- cord-302953-gr2kk9w4 143 4 26 26 CD cord-302953-gr2kk9w4 143 5 ] ] -RRB- cord-302953-gr2kk9w4 143 6 were be VBD cord-302953-gr2kk9w4 143 7 examined examine VBN cord-302953-gr2kk9w4 143 8 by by IN cord-302953-gr2kk9w4 143 9 qRT qRT NNP cord-302953-gr2kk9w4 143 10 - - HYPH cord-302953-gr2kk9w4 143 11 PCR PCR NNP cord-302953-gr2kk9w4 143 12 ( ( -LRB- cord-302953-gr2kk9w4 143 13 Figure Figure NNP cord-302953-gr2kk9w4 143 14 4 4 CD cord-302953-gr2kk9w4 143 15 ) ) -RRB- cord-302953-gr2kk9w4 143 16 . . . cord-302953-gr2kk9w4 144 1 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 144 2 , , , cord-302953-gr2kk9w4 144 3 Irgm1 irgm1 UH cord-302953-gr2kk9w4 144 4 , , , cord-302953-gr2kk9w4 144 5 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 144 6 , , , cord-302953-gr2kk9w4 144 7 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 144 8 , , , cord-302953-gr2kk9w4 144 9 and and CC cord-302953-gr2kk9w4 144 10 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 144 11 were be VBD cord-302953-gr2kk9w4 144 12 up up RB cord-302953-gr2kk9w4 144 13 regulated regulate VBN cord-302953-gr2kk9w4 144 14 in in IN cord-302953-gr2kk9w4 144 15 the the DT cord-302953-gr2kk9w4 144 16 brains brain NNS cord-302953-gr2kk9w4 144 17 and and CC cord-302953-gr2kk9w4 144 18 spinal spinal JJ cord-302953-gr2kk9w4 144 19 cords cord NNS cord-302953-gr2kk9w4 144 20 of of IN cord-302953-gr2kk9w4 144 21 all all DT cord-302953-gr2kk9w4 144 22 mice mouse NNS cord-302953-gr2kk9w4 144 23 during during IN cord-302953-gr2kk9w4 144 24 SINV SINV NNP cord-302953-gr2kk9w4 144 25 infection infection NN cord-302953-gr2kk9w4 144 26 , , , cord-302953-gr2kk9w4 144 27 likely likely RB cord-302953-gr2kk9w4 144 28 reflecting reflect VBG cord-302953-gr2kk9w4 144 29 the the DT cord-302953-gr2kk9w4 144 30 overlap overlap NN cord-302953-gr2kk9w4 144 31 with with IN cord-302953-gr2kk9w4 144 32 ISGs isg NNS cord-302953-gr2kk9w4 144 33 induced induce VBN cord-302953-gr2kk9w4 144 34 by by IN cord-302953-gr2kk9w4 144 35 type type NN cord-302953-gr2kk9w4 144 36 I -PRON- PRP cord-302953-gr2kk9w4 144 37 IFN IFN NNP cord-302953-gr2kk9w4 144 38 . . . cord-302953-gr2kk9w4 145 1 However however RB cord-302953-gr2kk9w4 145 2 , , , cord-302953-gr2kk9w4 145 3 expression expression NN cord-302953-gr2kk9w4 145 4 of of IN cord-302953-gr2kk9w4 145 5 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 145 6 ( ( -LRB- cord-302953-gr2kk9w4 145 7 Figure figure NN cord-302953-gr2kk9w4 145 8 4A 4a CD cord-302953-gr2kk9w4 145 9 ) ) -RRB- cord-302953-gr2kk9w4 145 10 and and CC cord-302953-gr2kk9w4 145 11 Irgm1 irgm1 FW cord-302953-gr2kk9w4 145 12 ( ( -LRB- cord-302953-gr2kk9w4 145 13 Figure figure NN cord-302953-gr2kk9w4 145 14 4B 4b CD cord-302953-gr2kk9w4 145 15 ) ) -RRB- cord-302953-gr2kk9w4 145 16 at at IN cord-302953-gr2kk9w4 145 17 5 5 CD cord-302953-gr2kk9w4 145 18 - - SYM cord-302953-gr2kk9w4 145 19 10 10 CD cord-302953-gr2kk9w4 145 20 DPI DPI NNP cord-302953-gr2kk9w4 145 21 in in IN cord-302953-gr2kk9w4 145 22 the the DT cord-302953-gr2kk9w4 145 23 brain brain NN cord-302953-gr2kk9w4 145 24 and and CC cord-302953-gr2kk9w4 145 25 spinal spinal JJ cord-302953-gr2kk9w4 145 26 cord cord NN cord-302953-gr2kk9w4 145 27 were be VBD cord-302953-gr2kk9w4 145 28 higher high JJR cord-302953-gr2kk9w4 145 29 in in IN cord-302953-gr2kk9w4 145 30 WT WT NNP cord-302953-gr2kk9w4 145 31 mice mouse NNS cord-302953-gr2kk9w4 145 32 than than IN cord-302953-gr2kk9w4 145 33 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 145 34 −/− −/− NNP cord-302953-gr2kk9w4 145 35 and and CC cord-302953-gr2kk9w4 145 36 Ifng Ifng NNP cord-302953-gr2kk9w4 145 37 −/− −/− NNP cord-302953-gr2kk9w4 145 38 mice mouse NNS cord-302953-gr2kk9w4 145 39 . . . cord-302953-gr2kk9w4 146 1 Smaller small JJR cord-302953-gr2kk9w4 146 2 differences difference NNS cord-302953-gr2kk9w4 146 3 in in IN cord-302953-gr2kk9w4 146 4 expression expression NN cord-302953-gr2kk9w4 146 5 levels level NNS cord-302953-gr2kk9w4 146 6 in in IN cord-302953-gr2kk9w4 146 7 brain brain NN cord-302953-gr2kk9w4 146 8 were be VBD cord-302953-gr2kk9w4 146 9 seen see VBN cord-302953-gr2kk9w4 146 10 at at IN cord-302953-gr2kk9w4 146 11 day day NN cord-302953-gr2kk9w4 146 12 5 5 CD cord-302953-gr2kk9w4 146 13 and and CC cord-302953-gr2kk9w4 146 14 7 7 CD cord-302953-gr2kk9w4 146 15 for for IN cord-302953-gr2kk9w4 146 16 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 146 17 ( ( -LRB- cord-302953-gr2kk9w4 146 18 Figure figure NN cord-302953-gr2kk9w4 146 19 4C 4c CD cord-302953-gr2kk9w4 146 20 ) ) -RRB- cord-302953-gr2kk9w4 146 21 and and CC cord-302953-gr2kk9w4 146 22 at at IN cord-302953-gr2kk9w4 146 23 3 3 CD cord-302953-gr2kk9w4 146 24 DPI DPI NNP cord-302953-gr2kk9w4 146 25 Oas1a Oas1a NNP cord-302953-gr2kk9w4 146 26 ( ( -LRB- cord-302953-gr2kk9w4 146 27 Figure figure NN cord-302953-gr2kk9w4 146 28 4D 4d CD cord-302953-gr2kk9w4 146 29 ) ) -RRB- cord-302953-gr2kk9w4 146 30 and and CC cord-302953-gr2kk9w4 146 31 at at IN cord-302953-gr2kk9w4 146 32 7 7 CD cord-302953-gr2kk9w4 146 33 DPI DPI NNP cord-302953-gr2kk9w4 146 34 for for IN cord-302953-gr2kk9w4 146 35 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 147 1 ( ( -LRB- cord-302953-gr2kk9w4 147 2 Figure figure NN cord-302953-gr2kk9w4 147 3 4E 4e NN cord-302953-gr2kk9w4 147 4 ) ) -RRB- cord-302953-gr2kk9w4 147 5 and and CC cord-302953-gr2kk9w4 147 6 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 148 1 ( ( -LRB- cord-302953-gr2kk9w4 148 2 Figure figure NN cord-302953-gr2kk9w4 148 3 4F 4f CD cord-302953-gr2kk9w4 148 4 ) ) -RRB- cord-302953-gr2kk9w4 148 5 . . . cord-302953-gr2kk9w4 149 1 These these DT cord-302953-gr2kk9w4 149 2 results result NNS cord-302953-gr2kk9w4 149 3 show show VBP cord-302953-gr2kk9w4 149 4 that that IN cord-302953-gr2kk9w4 149 5 while while IN cord-302953-gr2kk9w4 149 6 ISGs isg NNS cord-302953-gr2kk9w4 149 7 are be VBP cord-302953-gr2kk9w4 149 8 induced induce VBN cord-302953-gr2kk9w4 149 9 during during IN cord-302953-gr2kk9w4 149 10 SINV SINV NNP cord-302953-gr2kk9w4 149 11 infection infection NN cord-302953-gr2kk9w4 149 12 in in IN cord-302953-gr2kk9w4 149 13 the the DT cord-302953-gr2kk9w4 149 14 CNS CNS NNP cord-302953-gr2kk9w4 149 15 of of IN cord-302953-gr2kk9w4 149 16 mice mouse NNS cord-302953-gr2kk9w4 149 17 with with IN cord-302953-gr2kk9w4 149 18 impaired impaired JJ cord-302953-gr2kk9w4 149 19 IFN IFN NNP cord-302953-gr2kk9w4 149 20 - - HYPH cord-302953-gr2kk9w4 149 21 γ γ NNP cord-302953-gr2kk9w4 149 22 signaling signaling NN cord-302953-gr2kk9w4 149 23 , , , cord-302953-gr2kk9w4 149 24 expression expression NN cord-302953-gr2kk9w4 149 25 is be VBZ cord-302953-gr2kk9w4 149 26 diminished diminish VBN cord-302953-gr2kk9w4 149 27 compared compare VBN cord-302953-gr2kk9w4 149 28 to to IN cord-302953-gr2kk9w4 149 29 that that DT cord-302953-gr2kk9w4 149 30 of of IN cord-302953-gr2kk9w4 149 31 mice mouse NNS cord-302953-gr2kk9w4 149 32 with with IN cord-302953-gr2kk9w4 149 33 intact intact JJ cord-302953-gr2kk9w4 149 34 IFN IFN NNP cord-302953-gr2kk9w4 149 35 - - HYPH cord-302953-gr2kk9w4 149 36 γ γ NNP cord-302953-gr2kk9w4 149 37 signaling signaling NN cord-302953-gr2kk9w4 149 38 . . . cord-302953-gr2kk9w4 150 1 Viruses virus NNS cord-302953-gr2kk9w4 150 2 2019 2019 CD cord-302953-gr2kk9w4 150 3 , , , cord-302953-gr2kk9w4 150 4 11 11 CD cord-302953-gr2kk9w4 150 5 , , , cord-302953-gr2kk9w4 150 6 x x NN cord-302953-gr2kk9w4 150 7 FOR for IN cord-302953-gr2kk9w4 150 8 PEER peer NN cord-302953-gr2kk9w4 150 9 REVIEW REVIEW NNP cord-302953-gr2kk9w4 150 10 9 9 CD cord-302953-gr2kk9w4 150 11 of of IN cord-302953-gr2kk9w4 150 12 25 25 CD cord-302953-gr2kk9w4 150 13 cord cord NN cord-302953-gr2kk9w4 150 14 were be VBD cord-302953-gr2kk9w4 150 15 higher high JJR cord-302953-gr2kk9w4 150 16 in in IN cord-302953-gr2kk9w4 150 17 WT WT NNP cord-302953-gr2kk9w4 150 18 mice mouse NNS cord-302953-gr2kk9w4 150 19 than than IN cord-302953-gr2kk9w4 150 20 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 150 21 −/− −/− NNP cord-302953-gr2kk9w4 150 22 and and CC cord-302953-gr2kk9w4 150 23 Ifng Ifng NNP cord-302953-gr2kk9w4 150 24 −/− −/− NNP cord-302953-gr2kk9w4 150 25 mice mouse NNS cord-302953-gr2kk9w4 150 26 . . . cord-302953-gr2kk9w4 151 1 Smaller small JJR cord-302953-gr2kk9w4 151 2 differences difference NNS cord-302953-gr2kk9w4 151 3 in in IN cord-302953-gr2kk9w4 151 4 expression expression NN cord-302953-gr2kk9w4 151 5 levels level NNS cord-302953-gr2kk9w4 151 6 in in IN cord-302953-gr2kk9w4 151 7 brain brain NN cord-302953-gr2kk9w4 151 8 were be VBD cord-302953-gr2kk9w4 151 9 seen see VBN cord-302953-gr2kk9w4 151 10 at at IN cord-302953-gr2kk9w4 151 11 day day NN cord-302953-gr2kk9w4 151 12 5 5 CD cord-302953-gr2kk9w4 151 13 and and CC cord-302953-gr2kk9w4 151 14 7 7 CD cord-302953-gr2kk9w4 151 15 for for IN cord-302953-gr2kk9w4 151 16 Oasl2 Oasl2 NNP cord-302953-gr2kk9w4 151 17 ( ( -LRB- cord-302953-gr2kk9w4 151 18 Figure figure NN cord-302953-gr2kk9w4 151 19 4C 4c CD cord-302953-gr2kk9w4 151 20 ) ) -RRB- cord-302953-gr2kk9w4 151 21 and and CC cord-302953-gr2kk9w4 151 22 at at IN cord-302953-gr2kk9w4 151 23 3 3 CD cord-302953-gr2kk9w4 151 24 DPI DPI NNP cord-302953-gr2kk9w4 151 25 Oas1a Oas1a NNP cord-302953-gr2kk9w4 151 26 ( ( -LRB- cord-302953-gr2kk9w4 151 27 Figure figure NN cord-302953-gr2kk9w4 151 28 4D 4d CD cord-302953-gr2kk9w4 151 29 ) ) -RRB- cord-302953-gr2kk9w4 151 30 and and CC cord-302953-gr2kk9w4 151 31 at at IN cord-302953-gr2kk9w4 151 32 7 7 CD cord-302953-gr2kk9w4 151 33 DPI DPI NNP cord-302953-gr2kk9w4 151 34 for for IN cord-302953-gr2kk9w4 151 35 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 152 1 ( ( -LRB- cord-302953-gr2kk9w4 152 2 Figure figure NN cord-302953-gr2kk9w4 152 3 4E 4e NN cord-302953-gr2kk9w4 152 4 ) ) -RRB- cord-302953-gr2kk9w4 152 5 and and CC cord-302953-gr2kk9w4 152 6 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 153 1 ( ( -LRB- cord-302953-gr2kk9w4 153 2 Figure figure NN cord-302953-gr2kk9w4 153 3 4F 4f CD cord-302953-gr2kk9w4 153 4 ) ) -RRB- cord-302953-gr2kk9w4 153 5 . . . cord-302953-gr2kk9w4 154 1 These these DT cord-302953-gr2kk9w4 154 2 results result NNS cord-302953-gr2kk9w4 154 3 show show VBP cord-302953-gr2kk9w4 154 4 that that IN cord-302953-gr2kk9w4 154 5 while while IN cord-302953-gr2kk9w4 154 6 ISGs isg NNS cord-302953-gr2kk9w4 154 7 are be VBP cord-302953-gr2kk9w4 154 8 induced induce VBN cord-302953-gr2kk9w4 154 9 during during IN cord-302953-gr2kk9w4 154 10 SINV SINV NNP cord-302953-gr2kk9w4 154 11 infection infection NN cord-302953-gr2kk9w4 154 12 in in IN cord-302953-gr2kk9w4 154 13 the the DT cord-302953-gr2kk9w4 154 14 CNS CNS NNP cord-302953-gr2kk9w4 154 15 of of IN cord-302953-gr2kk9w4 154 16 mice mouse NNS cord-302953-gr2kk9w4 154 17 with with IN cord-302953-gr2kk9w4 154 18 impaired impaired JJ cord-302953-gr2kk9w4 154 19 IFN IFN NNP cord-302953-gr2kk9w4 154 20 - - HYPH cord-302953-gr2kk9w4 154 21 γ γ NNP cord-302953-gr2kk9w4 154 22 signaling signaling NN cord-302953-gr2kk9w4 154 23 , , , cord-302953-gr2kk9w4 154 24 expression expression NN cord-302953-gr2kk9w4 154 25 is be VBZ cord-302953-gr2kk9w4 154 26 diminished diminish VBN cord-302953-gr2kk9w4 154 27 compared compare VBN cord-302953-gr2kk9w4 154 28 to to IN cord-302953-gr2kk9w4 154 29 that that DT cord-302953-gr2kk9w4 154 30 of of IN cord-302953-gr2kk9w4 154 31 mice mouse NNS cord-302953-gr2kk9w4 154 32 with with IN cord-302953-gr2kk9w4 154 33 intact intact JJ cord-302953-gr2kk9w4 154 34 IFN IFN NNP cord-302953-gr2kk9w4 154 35 - - HYPH cord-302953-gr2kk9w4 154 36 γ γ NNP cord-302953-gr2kk9w4 154 37 signaling signaling NN cord-302953-gr2kk9w4 154 38 . . . cord-302953-gr2kk9w4 154 39 _SP cord-302953-gr2kk9w4 155 1 Clearance clearance NN cord-302953-gr2kk9w4 155 2 of of IN cord-302953-gr2kk9w4 155 3 viral viral JJ cord-302953-gr2kk9w4 155 4 RNA RNA NNP cord-302953-gr2kk9w4 155 5 from from IN cord-302953-gr2kk9w4 155 6 the the DT cord-302953-gr2kk9w4 155 7 CNS CNS NNP cord-302953-gr2kk9w4 155 8 was be VBD cord-302953-gr2kk9w4 155 9 examined examine VBN cord-302953-gr2kk9w4 155 10 by by IN cord-302953-gr2kk9w4 155 11 quantifying quantify VBG cord-302953-gr2kk9w4 155 12 SINV SINV NNP cord-302953-gr2kk9w4 155 13 RNA RNA NNP cord-302953-gr2kk9w4 155 14 in in IN cord-302953-gr2kk9w4 155 15 brains brain NNS cord-302953-gr2kk9w4 155 16 and and CC cord-302953-gr2kk9w4 155 17 spinal spinal JJ cord-302953-gr2kk9w4 155 18 cords cord NNS cord-302953-gr2kk9w4 155 19 of of IN cord-302953-gr2kk9w4 155 20 SINV SINV NNP cord-302953-gr2kk9w4 155 21 - - HYPH cord-302953-gr2kk9w4 155 22 infected infect VBN cord-302953-gr2kk9w4 155 23 WT WT NNP cord-302953-gr2kk9w4 155 24 , , , cord-302953-gr2kk9w4 155 25 Ifng Ifng NNP cord-302953-gr2kk9w4 155 26 −/− −/− NNP cord-302953-gr2kk9w4 155 27 and and CC cord-302953-gr2kk9w4 155 28 Ifnrg Ifnrg NNP cord-302953-gr2kk9w4 155 29 −/− −/− NNP cord-302953-gr2kk9w4 155 30 mice mouse NNS cord-302953-gr2kk9w4 155 31 by by IN cord-302953-gr2kk9w4 155 32 qRT qRT NNP cord-302953-gr2kk9w4 155 33 - - HYPH cord-302953-gr2kk9w4 155 34 PCR PCR NNP cord-302953-gr2kk9w4 155 35 using use VBG cord-302953-gr2kk9w4 155 36 primers primer NNS cord-302953-gr2kk9w4 155 37 specific specific JJ cord-302953-gr2kk9w4 155 38 for for IN cord-302953-gr2kk9w4 155 39 the the DT cord-302953-gr2kk9w4 155 40 E2 E2 NNP cord-302953-gr2kk9w4 155 41 gene gene NN cord-302953-gr2kk9w4 155 42 ( ( -LRB- cord-302953-gr2kk9w4 155 43 Figure figure NN cord-302953-gr2kk9w4 155 44 5 5 CD cord-302953-gr2kk9w4 155 45 ) ) -RRB- cord-302953-gr2kk9w4 155 46 . . . cord-302953-gr2kk9w4 156 1 Viral Viral NNP cord-302953-gr2kk9w4 156 2 RNA RNA NNP cord-302953-gr2kk9w4 156 3 peaked peak VBD cord-302953-gr2kk9w4 156 4 at at IN cord-302953-gr2kk9w4 156 5 3 3 CD cord-302953-gr2kk9w4 156 6 to to TO cord-302953-gr2kk9w4 156 7 5 5 CD cord-302953-gr2kk9w4 156 8 DPI DPI NNP cord-302953-gr2kk9w4 156 9 in in IN cord-302953-gr2kk9w4 156 10 the the DT cord-302953-gr2kk9w4 156 11 brains brain NNS cord-302953-gr2kk9w4 156 12 ( ( -LRB- cord-302953-gr2kk9w4 156 13 Figure figure NN cord-302953-gr2kk9w4 156 14 5A 5a NN cord-302953-gr2kk9w4 156 15 ) ) -RRB- cord-302953-gr2kk9w4 156 16 and and CC cord-302953-gr2kk9w4 156 17 spinal spinal JJ cord-302953-gr2kk9w4 156 18 cords cord NNS cord-302953-gr2kk9w4 157 1 ( ( -LRB- cord-302953-gr2kk9w4 157 2 Figure figure NN cord-302953-gr2kk9w4 157 3 _SP cord-302953-gr2kk9w4 157 4 5B 5b NN cord-302953-gr2kk9w4 157 5 ) ) -RRB- cord-302953-gr2kk9w4 157 6 , , , cord-302953-gr2kk9w4 157 7 with with IN cord-302953-gr2kk9w4 157 8 comparable comparable JJ cord-302953-gr2kk9w4 157 9 amounts amount NNS cord-302953-gr2kk9w4 157 10 for for IN cord-302953-gr2kk9w4 157 11 all all DT cord-302953-gr2kk9w4 157 12 mice mouse NNS cord-302953-gr2kk9w4 157 13 . . . cord-302953-gr2kk9w4 158 1 However however RB cord-302953-gr2kk9w4 158 2 , , , cord-302953-gr2kk9w4 158 3 at at IN cord-302953-gr2kk9w4 158 4 7 7 CD cord-302953-gr2kk9w4 158 5 DPI DPI NNP cord-302953-gr2kk9w4 158 6 , , , cord-302953-gr2kk9w4 158 7 viral viral JJ cord-302953-gr2kk9w4 158 8 RNA RNA NNP cord-302953-gr2kk9w4 158 9 levels level NNS cord-302953-gr2kk9w4 158 10 were be VBD cord-302953-gr2kk9w4 158 11 higher high JJR cord-302953-gr2kk9w4 158 12 in in IN cord-302953-gr2kk9w4 158 13 the the DT cord-302953-gr2kk9w4 158 14 brains brain NNS cord-302953-gr2kk9w4 158 15 and and CC cord-302953-gr2kk9w4 158 16 at at IN cord-302953-gr2kk9w4 158 17 5 5 CD cord-302953-gr2kk9w4 158 18 and and CC cord-302953-gr2kk9w4 158 19 7 7 CD cord-302953-gr2kk9w4 158 20 DPI DPI NNS cord-302953-gr2kk9w4 158 21 in in IN cord-302953-gr2kk9w4 158 22 the the DT cord-302953-gr2kk9w4 158 23 spinal spinal JJ cord-302953-gr2kk9w4 158 24 cords cord NNS cord-302953-gr2kk9w4 158 25 of of IN cord-302953-gr2kk9w4 158 26 WT WT NNP cord-302953-gr2kk9w4 158 27 mice mouse NNS cord-302953-gr2kk9w4 158 28 compared compare VBN cord-302953-gr2kk9w4 158 29 to to IN cord-302953-gr2kk9w4 158 30 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 158 31 −/− −/− NNP cord-302953-gr2kk9w4 158 32 and and CC cord-302953-gr2kk9w4 158 33 Ifng Ifng NNP cord-302953-gr2kk9w4 158 34 −/− −/− NNP cord-302953-gr2kk9w4 158 35 mice mouse NNS cord-302953-gr2kk9w4 158 36 . . . cord-302953-gr2kk9w4 159 1 Viral Viral NNP cord-302953-gr2kk9w4 159 2 RNA RNA NNP cord-302953-gr2kk9w4 159 3 levels level NNS cord-302953-gr2kk9w4 159 4 were be VBD cord-302953-gr2kk9w4 159 5 comparable comparable JJ cord-302953-gr2kk9w4 159 6 throughout throughout IN cord-302953-gr2kk9w4 159 7 Phase Phase NNP cord-302953-gr2kk9w4 159 8 2 2 CD cord-302953-gr2kk9w4 159 9 of of IN cord-302953-gr2kk9w4 159 10 infection infection NN cord-302953-gr2kk9w4 159 11 ; ; : cord-302953-gr2kk9w4 159 12 however however RB cord-302953-gr2kk9w4 159 13 , , , cord-302953-gr2kk9w4 159 14 at at IN cord-302953-gr2kk9w4 159 15 occasional occasional JJ cord-302953-gr2kk9w4 159 16 times time NNS cord-302953-gr2kk9w4 159 17 during during IN cord-302953-gr2kk9w4 159 18 Phase phase NN cord-302953-gr2kk9w4 159 19 3 3 CD cord-302953-gr2kk9w4 159 20 , , , cord-302953-gr2kk9w4 159 21 when when WRB cord-302953-gr2kk9w4 159 22 viral viral JJ cord-302953-gr2kk9w4 159 23 RNA RNA NNP cord-302953-gr2kk9w4 159 24 had have VBD cord-302953-gr2kk9w4 159 25 reached reach VBN cord-302953-gr2kk9w4 159 26 a a DT cord-302953-gr2kk9w4 159 27 low low JJ cord-302953-gr2kk9w4 159 28 - - HYPH cord-302953-gr2kk9w4 159 29 level level NN cord-302953-gr2kk9w4 159 30 steady steady JJ cord-302953-gr2kk9w4 159 31 state state NN cord-302953-gr2kk9w4 159 32 , , , cord-302953-gr2kk9w4 159 33 viral viral JJ cord-302953-gr2kk9w4 159 34 RNA RNA NNP cord-302953-gr2kk9w4 159 35 increased increase VBD cord-302953-gr2kk9w4 159 36 , , , cord-302953-gr2kk9w4 159 37 especially especially RB cord-302953-gr2kk9w4 159 38 in in IN cord-302953-gr2kk9w4 159 39 the the DT cord-302953-gr2kk9w4 159 40 spinal spinal JJ cord-302953-gr2kk9w4 159 41 cords cord NNS cord-302953-gr2kk9w4 159 42 of of IN cord-302953-gr2kk9w4 159 43 Ifng Ifng NNP cord-302953-gr2kk9w4 159 44 −/− −/− NNP cord-302953-gr2kk9w4 159 45 mice mouse NNS cord-302953-gr2kk9w4 159 46 . . . cord-302953-gr2kk9w4 160 1 The the DT cord-302953-gr2kk9w4 160 2 results result NNS cord-302953-gr2kk9w4 160 3 indicate indicate VBP cord-302953-gr2kk9w4 160 4 that that IN cord-302953-gr2kk9w4 160 5 while while IN cord-302953-gr2kk9w4 160 6 impaired impaired JJ cord-302953-gr2kk9w4 160 7 IFN IFN NNP cord-302953-gr2kk9w4 160 8 - - HYPH cord-302953-gr2kk9w4 160 9 γ γ NNP cord-302953-gr2kk9w4 160 10 signaling signal VBG cord-302953-gr2kk9w4 160 11 results result NNS cord-302953-gr2kk9w4 160 12 in in IN cord-302953-gr2kk9w4 160 13 delayed delay VBN cord-302953-gr2kk9w4 160 14 infectious infectious JJ cord-302953-gr2kk9w4 160 15 virus virus NN cord-302953-gr2kk9w4 160 16 clearance clearance NN cord-302953-gr2kk9w4 160 17 [ [ -LRB- cord-302953-gr2kk9w4 160 18 7 7 CD cord-302953-gr2kk9w4 160 19 , , , cord-302953-gr2kk9w4 160 20 9 9 CD cord-302953-gr2kk9w4 160 21 , , , cord-302953-gr2kk9w4 160 22 30 30 CD cord-302953-gr2kk9w4 160 23 ] ] -RRB- cord-302953-gr2kk9w4 160 24 , , , cord-302953-gr2kk9w4 160 25 initiation initiation NN cord-302953-gr2kk9w4 160 26 of of IN cord-302953-gr2kk9w4 160 27 viral viral JJ cord-302953-gr2kk9w4 160 28 RNA RNA NNP cord-302953-gr2kk9w4 160 29 clearance clearance NN cord-302953-gr2kk9w4 160 30 was be VBD cord-302953-gr2kk9w4 160 31 accelerated accelerate VBN cord-302953-gr2kk9w4 160 32 , , , cord-302953-gr2kk9w4 160 33 but but CC cord-302953-gr2kk9w4 160 34 the the DT cord-302953-gr2kk9w4 160 35 likelihood likelihood NN cord-302953-gr2kk9w4 160 36 of of IN cord-302953-gr2kk9w4 160 37 reactivation reactivation NN cord-302953-gr2kk9w4 160 38 of of IN cord-302953-gr2kk9w4 160 39 viral viral JJ cord-302953-gr2kk9w4 160 40 RNA RNA NNP cord-302953-gr2kk9w4 160 41 synthesis synthesis NN cord-302953-gr2kk9w4 160 42 late late RB cord-302953-gr2kk9w4 160 43 after after IN cord-302953-gr2kk9w4 160 44 infection infection NN cord-302953-gr2kk9w4 160 45 was be VBD cord-302953-gr2kk9w4 160 46 increased increase VBN cord-302953-gr2kk9w4 160 47 . . . cord-302953-gr2kk9w4 160 48 _SP cord-302953-gr2kk9w4 161 1 Clearance clearance NN cord-302953-gr2kk9w4 161 2 of of IN cord-302953-gr2kk9w4 161 3 viral viral JJ cord-302953-gr2kk9w4 161 4 RNA RNA NNP cord-302953-gr2kk9w4 161 5 from from IN cord-302953-gr2kk9w4 161 6 the the DT cord-302953-gr2kk9w4 161 7 CNS CNS NNP cord-302953-gr2kk9w4 161 8 was be VBD cord-302953-gr2kk9w4 161 9 examined examine VBN cord-302953-gr2kk9w4 161 10 by by IN cord-302953-gr2kk9w4 161 11 quantifying quantify VBG cord-302953-gr2kk9w4 161 12 SINV SINV NNP cord-302953-gr2kk9w4 161 13 RNA RNA NNP cord-302953-gr2kk9w4 161 14 in in IN cord-302953-gr2kk9w4 161 15 brains brain NNS cord-302953-gr2kk9w4 161 16 and and CC cord-302953-gr2kk9w4 161 17 spinal spinal JJ cord-302953-gr2kk9w4 161 18 cords cord NNS cord-302953-gr2kk9w4 161 19 of of IN cord-302953-gr2kk9w4 161 20 SINV SINV NNP cord-302953-gr2kk9w4 161 21 - - HYPH cord-302953-gr2kk9w4 161 22 infected infect VBN cord-302953-gr2kk9w4 161 23 WT WT NNP cord-302953-gr2kk9w4 161 24 , , , cord-302953-gr2kk9w4 161 25 Ifng Ifng NNP cord-302953-gr2kk9w4 161 26 −/− −/− NNP cord-302953-gr2kk9w4 161 27 and and CC cord-302953-gr2kk9w4 161 28 Ifnrg Ifnrg NNP cord-302953-gr2kk9w4 161 29 −/− −/− NNP cord-302953-gr2kk9w4 161 30 mice mouse NNS cord-302953-gr2kk9w4 161 31 by by IN cord-302953-gr2kk9w4 161 32 qRT qRT NNP cord-302953-gr2kk9w4 161 33 - - HYPH cord-302953-gr2kk9w4 161 34 PCR PCR NNP cord-302953-gr2kk9w4 161 35 using use VBG cord-302953-gr2kk9w4 161 36 primers primer NNS cord-302953-gr2kk9w4 161 37 specific specific JJ cord-302953-gr2kk9w4 161 38 for for IN cord-302953-gr2kk9w4 161 39 the the DT cord-302953-gr2kk9w4 161 40 E2 E2 NNP cord-302953-gr2kk9w4 161 41 gene gene NN cord-302953-gr2kk9w4 161 42 ( ( -LRB- cord-302953-gr2kk9w4 161 43 Figure figure NN cord-302953-gr2kk9w4 161 44 5 5 CD cord-302953-gr2kk9w4 161 45 ) ) -RRB- cord-302953-gr2kk9w4 161 46 . . . cord-302953-gr2kk9w4 162 1 Viral Viral NNP cord-302953-gr2kk9w4 162 2 RNA RNA NNP cord-302953-gr2kk9w4 162 3 peaked peak VBD cord-302953-gr2kk9w4 162 4 at at IN cord-302953-gr2kk9w4 162 5 3 3 CD cord-302953-gr2kk9w4 162 6 to to TO cord-302953-gr2kk9w4 162 7 5 5 CD cord-302953-gr2kk9w4 162 8 DPI DPI NNP cord-302953-gr2kk9w4 162 9 in in IN cord-302953-gr2kk9w4 162 10 the the DT cord-302953-gr2kk9w4 162 11 brains brain NNS cord-302953-gr2kk9w4 162 12 ( ( -LRB- cord-302953-gr2kk9w4 162 13 Figure figure NN cord-302953-gr2kk9w4 162 14 5A 5a NN cord-302953-gr2kk9w4 162 15 ) ) -RRB- cord-302953-gr2kk9w4 162 16 and and CC cord-302953-gr2kk9w4 162 17 spinal spinal JJ cord-302953-gr2kk9w4 162 18 cords cord NNS cord-302953-gr2kk9w4 163 1 ( ( -LRB- cord-302953-gr2kk9w4 163 2 Figure figure NN cord-302953-gr2kk9w4 163 3 5B 5b NN cord-302953-gr2kk9w4 163 4 ) ) -RRB- cord-302953-gr2kk9w4 163 5 , , , cord-302953-gr2kk9w4 163 6 with with IN cord-302953-gr2kk9w4 163 7 comparable comparable JJ cord-302953-gr2kk9w4 163 8 amounts amount NNS cord-302953-gr2kk9w4 163 9 for for IN cord-302953-gr2kk9w4 163 10 all all DT cord-302953-gr2kk9w4 163 11 mice mouse NNS cord-302953-gr2kk9w4 163 12 . . . cord-302953-gr2kk9w4 164 1 However however RB cord-302953-gr2kk9w4 164 2 , , , cord-302953-gr2kk9w4 164 3 at at IN cord-302953-gr2kk9w4 164 4 7 7 CD cord-302953-gr2kk9w4 164 5 DPI DPI NNP cord-302953-gr2kk9w4 164 6 , , , cord-302953-gr2kk9w4 164 7 viral viral JJ cord-302953-gr2kk9w4 164 8 RNA RNA NNP cord-302953-gr2kk9w4 164 9 levels level NNS cord-302953-gr2kk9w4 164 10 were be VBD cord-302953-gr2kk9w4 164 11 higher high JJR cord-302953-gr2kk9w4 164 12 in in IN cord-302953-gr2kk9w4 164 13 the the DT cord-302953-gr2kk9w4 164 14 brains brain NNS cord-302953-gr2kk9w4 164 15 and and CC cord-302953-gr2kk9w4 164 16 at at IN cord-302953-gr2kk9w4 164 17 5 5 CD cord-302953-gr2kk9w4 164 18 and and CC cord-302953-gr2kk9w4 164 19 7 7 CD cord-302953-gr2kk9w4 164 20 DPI DPI NNS cord-302953-gr2kk9w4 164 21 in in IN cord-302953-gr2kk9w4 164 22 the the DT cord-302953-gr2kk9w4 164 23 spinal spinal JJ cord-302953-gr2kk9w4 164 24 cords cord NNS cord-302953-gr2kk9w4 164 25 of of IN cord-302953-gr2kk9w4 164 26 WT WT NNP cord-302953-gr2kk9w4 164 27 mice mouse NNS cord-302953-gr2kk9w4 164 28 compared compare VBN cord-302953-gr2kk9w4 164 29 to to IN cord-302953-gr2kk9w4 164 30 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 164 31 −/− −/− NNP cord-302953-gr2kk9w4 164 32 and and CC cord-302953-gr2kk9w4 164 33 Ifng Ifng NNP cord-302953-gr2kk9w4 164 34 −/− −/− NNP cord-302953-gr2kk9w4 164 35 mice mouse NNS cord-302953-gr2kk9w4 164 36 . . . cord-302953-gr2kk9w4 165 1 Viral Viral NNP cord-302953-gr2kk9w4 165 2 RNA RNA NNP cord-302953-gr2kk9w4 165 3 levels level NNS cord-302953-gr2kk9w4 165 4 were be VBD cord-302953-gr2kk9w4 165 5 comparable comparable JJ cord-302953-gr2kk9w4 165 6 throughout throughout IN cord-302953-gr2kk9w4 165 7 Phase Phase NNP cord-302953-gr2kk9w4 165 8 2 2 CD cord-302953-gr2kk9w4 165 9 of of IN cord-302953-gr2kk9w4 165 10 infection infection NN cord-302953-gr2kk9w4 165 11 ; ; : cord-302953-gr2kk9w4 165 12 however however RB cord-302953-gr2kk9w4 165 13 , , , cord-302953-gr2kk9w4 165 14 at at IN cord-302953-gr2kk9w4 165 15 occasional occasional JJ cord-302953-gr2kk9w4 165 16 times time NNS cord-302953-gr2kk9w4 165 17 during during IN cord-302953-gr2kk9w4 165 18 Phase phase NN cord-302953-gr2kk9w4 165 19 3 3 CD cord-302953-gr2kk9w4 165 20 , , , cord-302953-gr2kk9w4 165 21 when when WRB cord-302953-gr2kk9w4 165 22 viral viral JJ cord-302953-gr2kk9w4 165 23 RNA RNA NNP cord-302953-gr2kk9w4 165 24 had have VBD cord-302953-gr2kk9w4 165 25 reached reach VBN cord-302953-gr2kk9w4 165 26 a a DT cord-302953-gr2kk9w4 165 27 low low JJ cord-302953-gr2kk9w4 165 28 - - HYPH cord-302953-gr2kk9w4 165 29 level level NN cord-302953-gr2kk9w4 165 30 steady steady JJ cord-302953-gr2kk9w4 165 31 state state NN cord-302953-gr2kk9w4 165 32 , , , cord-302953-gr2kk9w4 165 33 viral viral JJ cord-302953-gr2kk9w4 165 34 RNA RNA NNP cord-302953-gr2kk9w4 165 35 increased increase VBD cord-302953-gr2kk9w4 165 36 , , , cord-302953-gr2kk9w4 165 37 especially especially RB cord-302953-gr2kk9w4 165 38 in in IN cord-302953-gr2kk9w4 165 39 the the DT cord-302953-gr2kk9w4 165 40 spinal spinal JJ cord-302953-gr2kk9w4 165 41 cords cord NNS cord-302953-gr2kk9w4 165 42 of of IN cord-302953-gr2kk9w4 165 43 Ifng Ifng NNP cord-302953-gr2kk9w4 165 44 −/− −/− NNP cord-302953-gr2kk9w4 165 45 mice mouse NNS cord-302953-gr2kk9w4 165 46 . . . cord-302953-gr2kk9w4 166 1 The the DT cord-302953-gr2kk9w4 166 2 results result NNS cord-302953-gr2kk9w4 166 3 indicate indicate VBP cord-302953-gr2kk9w4 166 4 that that IN cord-302953-gr2kk9w4 166 5 while while IN cord-302953-gr2kk9w4 166 6 impaired impaired JJ cord-302953-gr2kk9w4 166 7 IFN IFN NNP cord-302953-gr2kk9w4 166 8 - - HYPH cord-302953-gr2kk9w4 166 9 γ γ NNP cord-302953-gr2kk9w4 166 10 signaling signal VBG cord-302953-gr2kk9w4 166 11 results result NNS cord-302953-gr2kk9w4 166 12 in in IN cord-302953-gr2kk9w4 166 13 delayed delay VBN cord-302953-gr2kk9w4 166 14 infectious infectious JJ cord-302953-gr2kk9w4 166 15 virus virus NN cord-302953-gr2kk9w4 166 16 clearance clearance NN cord-302953-gr2kk9w4 166 17 [ [ -LRB- cord-302953-gr2kk9w4 166 18 7 7 CD cord-302953-gr2kk9w4 166 19 , , , cord-302953-gr2kk9w4 166 20 9 9 CD cord-302953-gr2kk9w4 166 21 , , , cord-302953-gr2kk9w4 166 22 30 30 CD cord-302953-gr2kk9w4 166 23 ] ] -RRB- cord-302953-gr2kk9w4 166 24 , , , cord-302953-gr2kk9w4 166 25 initiation initiation NN cord-302953-gr2kk9w4 166 26 of of IN cord-302953-gr2kk9w4 166 27 viral viral JJ cord-302953-gr2kk9w4 166 28 RNA RNA NNP cord-302953-gr2kk9w4 166 29 clearance clearance NN cord-302953-gr2kk9w4 166 30 was be VBD cord-302953-gr2kk9w4 166 31 accelerated accelerate VBN cord-302953-gr2kk9w4 166 32 , , , cord-302953-gr2kk9w4 166 33 but but CC cord-302953-gr2kk9w4 166 34 the the DT cord-302953-gr2kk9w4 166 35 likelihood likelihood NN cord-302953-gr2kk9w4 166 36 of of IN cord-302953-gr2kk9w4 166 37 reactivation reactivation NN cord-302953-gr2kk9w4 166 38 of of IN cord-302953-gr2kk9w4 166 39 viral viral JJ cord-302953-gr2kk9w4 166 40 RNA RNA NNP cord-302953-gr2kk9w4 166 41 synthesis synthesis NN cord-302953-gr2kk9w4 166 42 late late RB cord-302953-gr2kk9w4 166 43 after after IN cord-302953-gr2kk9w4 166 44 infection infection NN cord-302953-gr2kk9w4 166 45 was be VBD cord-302953-gr2kk9w4 166 46 increased increase VBN cord-302953-gr2kk9w4 166 47 . . . cord-302953-gr2kk9w4 166 48 _SP cord-302953-gr2kk9w4 167 1 To to TO cord-302953-gr2kk9w4 167 2 examine examine VB cord-302953-gr2kk9w4 167 3 the the DT cord-302953-gr2kk9w4 167 4 effect effect NN cord-302953-gr2kk9w4 167 5 of of IN cord-302953-gr2kk9w4 167 6 IFN IFN NNP cord-302953-gr2kk9w4 167 7 - - HYPH cord-302953-gr2kk9w4 167 8 γ γ NNP cord-302953-gr2kk9w4 167 9 signaling signal VBG cord-302953-gr2kk9w4 167 10 on on IN cord-302953-gr2kk9w4 167 11 the the DT cord-302953-gr2kk9w4 167 12 inflammatory inflammatory JJ cord-302953-gr2kk9w4 167 13 response response NN cord-302953-gr2kk9w4 167 14 to to IN cord-302953-gr2kk9w4 167 15 SINV SINV NNP cord-302953-gr2kk9w4 167 16 infection infection NN cord-302953-gr2kk9w4 167 17 , , , cord-302953-gr2kk9w4 167 18 we -PRON- PRP cord-302953-gr2kk9w4 167 19 first first RB cord-302953-gr2kk9w4 167 20 examined examine VBD cord-302953-gr2kk9w4 167 21 brain brain NN cord-302953-gr2kk9w4 167 22 and and CC cord-302953-gr2kk9w4 167 23 spinal spinal JJ cord-302953-gr2kk9w4 167 24 cord cord NN cord-302953-gr2kk9w4 167 25 pathology pathology NN cord-302953-gr2kk9w4 167 26 of of IN cord-302953-gr2kk9w4 167 27 SINV SINV NNP cord-302953-gr2kk9w4 167 28 - - HYPH cord-302953-gr2kk9w4 167 29 infected infect VBN cord-302953-gr2kk9w4 167 30 WT WT NNP cord-302953-gr2kk9w4 167 31 , , , cord-302953-gr2kk9w4 167 32 Ifng Ifng NNP cord-302953-gr2kk9w4 167 33 −/− −/− NNP cord-302953-gr2kk9w4 167 34 and and CC cord-302953-gr2kk9w4 167 35 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 167 36 −/− −/− NNP cord-302953-gr2kk9w4 167 37 mice mouse NNS cord-302953-gr2kk9w4 167 38 . . . cord-302953-gr2kk9w4 168 1 Most Most JJS cord-302953-gr2kk9w4 168 2 of of IN cord-302953-gr2kk9w4 168 3 the the DT cord-302953-gr2kk9w4 168 4 pathological pathological JJ cord-302953-gr2kk9w4 168 5 changes change NNS cord-302953-gr2kk9w4 168 6 seen see VBN cord-302953-gr2kk9w4 168 7 with with IN cord-302953-gr2kk9w4 168 8 alphavirus alphavirus NNP cord-302953-gr2kk9w4 168 9 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 168 10 are be VBP cord-302953-gr2kk9w4 168 11 associated associate VBN cord-302953-gr2kk9w4 168 12 with with IN cord-302953-gr2kk9w4 168 13 infiltration infiltration NN cord-302953-gr2kk9w4 168 14 of of IN cord-302953-gr2kk9w4 168 15 immune immune JJ cord-302953-gr2kk9w4 168 16 cells cell NNS cord-302953-gr2kk9w4 168 17 [ [ -LRB- cord-302953-gr2kk9w4 168 18 14 14 CD cord-302953-gr2kk9w4 168 19 , , , cord-302953-gr2kk9w4 168 20 23 23 CD cord-302953-gr2kk9w4 168 21 , , , cord-302953-gr2kk9w4 168 22 24 24 CD cord-302953-gr2kk9w4 168 23 , , , cord-302953-gr2kk9w4 168 24 [ [ -LRB- cord-302953-gr2kk9w4 168 25 31 31 CD cord-302953-gr2kk9w4 168 26 ] ] -RRB- cord-302953-gr2kk9w4 168 27 [ [ -LRB- cord-302953-gr2kk9w4 168 28 32 32 CD cord-302953-gr2kk9w4 168 29 ] ] -RRB- cord-302953-gr2kk9w4 168 30 [ [ -LRB- cord-302953-gr2kk9w4 168 31 33 33 CD cord-302953-gr2kk9w4 168 32 ] ] -RRB- cord-302953-gr2kk9w4 168 33 . . . cord-302953-gr2kk9w4 169 1 Brains brain NNS cord-302953-gr2kk9w4 169 2 and and CC cord-302953-gr2kk9w4 169 3 spinal spinal JJ cord-302953-gr2kk9w4 169 4 cords cord NNS cord-302953-gr2kk9w4 169 5 were be VBD cord-302953-gr2kk9w4 169 6 examined examine VBN cord-302953-gr2kk9w4 169 7 for for IN cord-302953-gr2kk9w4 169 8 histopathological histopathological JJ cord-302953-gr2kk9w4 169 9 changes change NNS cord-302953-gr2kk9w4 169 10 and and CC cord-302953-gr2kk9w4 169 11 inflammation inflammation NN cord-302953-gr2kk9w4 169 12 at at IN cord-302953-gr2kk9w4 169 13 0 0 CD cord-302953-gr2kk9w4 169 14 , , , cord-302953-gr2kk9w4 169 15 3 3 CD cord-302953-gr2kk9w4 169 16 , , , cord-302953-gr2kk9w4 169 17 5 5 CD cord-302953-gr2kk9w4 169 18 , , , cord-302953-gr2kk9w4 169 19 and and CC cord-302953-gr2kk9w4 169 20 7 7 CD cord-302953-gr2kk9w4 169 21 DPI DPI NNP cord-302953-gr2kk9w4 169 22 ( ( -LRB- cord-302953-gr2kk9w4 169 23 Figure Figure NNP cord-302953-gr2kk9w4 169 24 6 6 CD cord-302953-gr2kk9w4 169 25 ) ) -RRB- cord-302953-gr2kk9w4 169 26 . . . cord-302953-gr2kk9w4 170 1 Sporadically sporadically RB cord-302953-gr2kk9w4 170 2 at at IN cord-302953-gr2kk9w4 170 3 5 5 CD cord-302953-gr2kk9w4 170 4 DPI DPI NNP cord-302953-gr2kk9w4 170 5 and and CC cord-302953-gr2kk9w4 170 6 consistently consistently RB cord-302953-gr2kk9w4 170 7 at at IN cord-302953-gr2kk9w4 170 8 7 7 CD cord-302953-gr2kk9w4 170 9 DPI DPI NNP cord-302953-gr2kk9w4 170 10 , , , cord-302953-gr2kk9w4 170 11 brains brain NNS cord-302953-gr2kk9w4 170 12 from from IN cord-302953-gr2kk9w4 170 13 WT WT NNP cord-302953-gr2kk9w4 170 14 mice mouse NNS cord-302953-gr2kk9w4 170 15 had have VBD cord-302953-gr2kk9w4 170 16 diffuse diffuse JJ cord-302953-gr2kk9w4 170 17 bilateral bilateral JJ cord-302953-gr2kk9w4 170 18 dilation dilation NN cord-302953-gr2kk9w4 170 19 of of IN cord-302953-gr2kk9w4 170 20 the the DT cord-302953-gr2kk9w4 170 21 lateral lateral JJ cord-302953-gr2kk9w4 170 22 ventricles ventricle NNS cord-302953-gr2kk9w4 170 23 , , , cord-302953-gr2kk9w4 170 24 extending extend VBG cord-302953-gr2kk9w4 170 25 along along IN cord-302953-gr2kk9w4 170 26 the the DT cord-302953-gr2kk9w4 170 27 dorsal dorsal JJ cord-302953-gr2kk9w4 170 28 aspects aspect NNS cord-302953-gr2kk9w4 170 29 of of IN cord-302953-gr2kk9w4 170 30 the the DT cord-302953-gr2kk9w4 170 31 hippocampi hippocampus NNS cord-302953-gr2kk9w4 170 32 . . . cord-302953-gr2kk9w4 171 1 This this DT cord-302953-gr2kk9w4 171 2 change change NN cord-302953-gr2kk9w4 171 3 was be VBD cord-302953-gr2kk9w4 171 4 rarely rarely RB cord-302953-gr2kk9w4 171 5 seen see VBN cord-302953-gr2kk9w4 171 6 in in IN cord-302953-gr2kk9w4 171 7 brains brain NNS cord-302953-gr2kk9w4 171 8 from from IN cord-302953-gr2kk9w4 171 9 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 171 10 −/− −/− NNP cord-302953-gr2kk9w4 171 11 or or CC cord-302953-gr2kk9w4 171 12 Ifng Ifng NNP cord-302953-gr2kk9w4 171 13 −/− −/− NNP cord-302953-gr2kk9w4 171 14 mice mouse NNS cord-302953-gr2kk9w4 171 15 , , , cord-302953-gr2kk9w4 171 16 and and CC cord-302953-gr2kk9w4 171 17 when when WRB cord-302953-gr2kk9w4 171 18 present present JJ cord-302953-gr2kk9w4 171 19 , , , cord-302953-gr2kk9w4 171 20 was be VBD cord-302953-gr2kk9w4 171 21 less less RBR cord-302953-gr2kk9w4 171 22 severe severe JJ cord-302953-gr2kk9w4 171 23 . . . cord-302953-gr2kk9w4 172 1 Compared compare VBN cord-302953-gr2kk9w4 172 2 to to TO cord-302953-gr2kk9w4 172 3 mock mock VB cord-302953-gr2kk9w4 172 4 - - HYPH cord-302953-gr2kk9w4 172 5 infected infected JJ cord-302953-gr2kk9w4 172 6 control control NN cord-302953-gr2kk9w4 172 7 mice mouse NNS cord-302953-gr2kk9w4 172 8 ( ( -LRB- cord-302953-gr2kk9w4 172 9 Figure figure NN cord-302953-gr2kk9w4 172 10 6A 6a CD cord-302953-gr2kk9w4 172 11 ) ) -RRB- cord-302953-gr2kk9w4 172 12 , , , cord-302953-gr2kk9w4 172 13 both both DT cord-302953-gr2kk9w4 172 14 perivascular perivascular JJ cord-302953-gr2kk9w4 172 15 cuffing cuffing NN cord-302953-gr2kk9w4 172 16 and and CC cord-302953-gr2kk9w4 172 17 infiltration infiltration NN cord-302953-gr2kk9w4 172 18 of of IN cord-302953-gr2kk9w4 172 19 mononuclear mononuclear JJ cord-302953-gr2kk9w4 172 20 cells cell NNS cord-302953-gr2kk9w4 172 21 into into IN cord-302953-gr2kk9w4 172 22 the the DT cord-302953-gr2kk9w4 172 23 parenchyma parenchyma NN cord-302953-gr2kk9w4 172 24 in in IN cord-302953-gr2kk9w4 172 25 the the DT cord-302953-gr2kk9w4 172 26 brain brain NN cord-302953-gr2kk9w4 172 27 were be VBD cord-302953-gr2kk9w4 172 28 present present JJ cord-302953-gr2kk9w4 172 29 at at IN cord-302953-gr2kk9w4 172 30 7 7 CD cord-302953-gr2kk9w4 172 31 DPI DPI NNP cord-302953-gr2kk9w4 172 32 in in IN cord-302953-gr2kk9w4 172 33 all all DT cord-302953-gr2kk9w4 172 34 SINV SINV NNP cord-302953-gr2kk9w4 172 35 - - HYPH cord-302953-gr2kk9w4 172 36 infected infect VBN cord-302953-gr2kk9w4 172 37 mice mouse NNS cord-302953-gr2kk9w4 172 38 ( ( -LRB- cord-302953-gr2kk9w4 172 39 Figure figure NN cord-302953-gr2kk9w4 172 40 6B 6b NN cord-302953-gr2kk9w4 172 41 ) ) -RRB- cord-302953-gr2kk9w4 172 42 . . . cord-302953-gr2kk9w4 173 1 In in IN cord-302953-gr2kk9w4 173 2 the the DT cord-302953-gr2kk9w4 173 3 spinal spinal JJ cord-302953-gr2kk9w4 173 4 cord cord NN cord-302953-gr2kk9w4 173 5 , , , cord-302953-gr2kk9w4 173 6 compared compare VBN cord-302953-gr2kk9w4 173 7 to to IN cord-302953-gr2kk9w4 173 8 mock mock VB cord-302953-gr2kk9w4 173 9 - - HYPH cord-302953-gr2kk9w4 173 10 infected infect VBN cord-302953-gr2kk9w4 173 11 controls control NNS cord-302953-gr2kk9w4 173 12 ( ( -LRB- cord-302953-gr2kk9w4 173 13 Figure figure NN cord-302953-gr2kk9w4 173 14 6C 6c NN cord-302953-gr2kk9w4 173 15 ) ) -RRB- cord-302953-gr2kk9w4 173 16 , , , cord-302953-gr2kk9w4 173 17 SINV SINV NNP cord-302953-gr2kk9w4 173 18 - - HYPH cord-302953-gr2kk9w4 173 19 infected infect VBN cord-302953-gr2kk9w4 173 20 WT WT NNP cord-302953-gr2kk9w4 173 21 and and CC cord-302953-gr2kk9w4 173 22 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 174 1 −/− −/− NNP cord-302953-gr2kk9w4 174 2 mice mouse NNS cord-302953-gr2kk9w4 174 3 had have VBD cord-302953-gr2kk9w4 174 4 more more JJR cord-302953-gr2kk9w4 174 5 inflammation inflammation NN cord-302953-gr2kk9w4 174 6 than than IN cord-302953-gr2kk9w4 174 7 Ifng Ifng NNP cord-302953-gr2kk9w4 174 8 −/− −/− NNP cord-302953-gr2kk9w4 174 9 mice mouse NNS cord-302953-gr2kk9w4 174 10 ( ( -LRB- cord-302953-gr2kk9w4 174 11 Figure figure NN cord-302953-gr2kk9w4 174 12 6D 6d NN cord-302953-gr2kk9w4 174 13 ) ) -RRB- cord-302953-gr2kk9w4 174 14 . . . cord-302953-gr2kk9w4 175 1 For for IN cord-302953-gr2kk9w4 175 2 quantitative quantitative JJ cord-302953-gr2kk9w4 175 3 comparison comparison NN cord-302953-gr2kk9w4 175 4 of of IN cord-302953-gr2kk9w4 175 5 the the DT cord-302953-gr2kk9w4 175 6 inflammation inflammation NN cord-302953-gr2kk9w4 175 7 in in IN cord-302953-gr2kk9w4 175 8 brain brain NN cord-302953-gr2kk9w4 175 9 ( ( -LRB- cord-302953-gr2kk9w4 175 10 Figure Figure NNP cord-302953-gr2kk9w4 175 11 6E 6E NNP cord-302953-gr2kk9w4 175 12 ) ) -RRB- cord-302953-gr2kk9w4 175 13 and and CC cord-302953-gr2kk9w4 175 14 spinal spinal JJ cord-302953-gr2kk9w4 175 15 cord cord NN cord-302953-gr2kk9w4 175 16 ( ( -LRB- cord-302953-gr2kk9w4 175 17 Figure figure NN cord-302953-gr2kk9w4 175 18 6F 6f NN cord-302953-gr2kk9w4 175 19 ) ) -RRB- cord-302953-gr2kk9w4 175 20 at at IN cord-302953-gr2kk9w4 175 21 3 3 CD cord-302953-gr2kk9w4 175 22 , , , cord-302953-gr2kk9w4 175 23 5 5 CD cord-302953-gr2kk9w4 175 24 , , , cord-302953-gr2kk9w4 175 25 and and CC cord-302953-gr2kk9w4 175 26 7 7 CD cord-302953-gr2kk9w4 175 27 DPI DPI NNP cord-302953-gr2kk9w4 175 28 , , , cord-302953-gr2kk9w4 175 29 a a DT cord-302953-gr2kk9w4 175 30 scoring scoring NN cord-302953-gr2kk9w4 175 31 system system NN cord-302953-gr2kk9w4 175 32 was be VBD cord-302953-gr2kk9w4 175 33 used use VBN cord-302953-gr2kk9w4 175 34 to to TO cord-302953-gr2kk9w4 175 35 evaluate evaluate VB cord-302953-gr2kk9w4 175 36 coded code VBN cord-302953-gr2kk9w4 175 37 H&E H&E NNP cord-302953-gr2kk9w4 175 38 - - HYPH cord-302953-gr2kk9w4 175 39 stained stain VBN cord-302953-gr2kk9w4 175 40 sections section NNS cord-302953-gr2kk9w4 175 41 [ [ -LRB- cord-302953-gr2kk9w4 175 42 23 23 CD cord-302953-gr2kk9w4 175 43 , , , cord-302953-gr2kk9w4 175 44 24 24 CD cord-302953-gr2kk9w4 175 45 ] ] -RRB- cord-302953-gr2kk9w4 175 46 . . . cord-302953-gr2kk9w4 176 1 Inflammation inflammation NN cord-302953-gr2kk9w4 176 2 steadily steadily RB cord-302953-gr2kk9w4 176 3 increased increase VBD cord-302953-gr2kk9w4 176 4 during during IN cord-302953-gr2kk9w4 176 5 the the DT cord-302953-gr2kk9w4 176 6 first first JJ cord-302953-gr2kk9w4 176 7 week week NN cord-302953-gr2kk9w4 176 8 of of IN cord-302953-gr2kk9w4 176 9 infection infection NN cord-302953-gr2kk9w4 176 10 , , , cord-302953-gr2kk9w4 176 11 peaking peak VBG cord-302953-gr2kk9w4 176 12 at at IN cord-302953-gr2kk9w4 176 13 7 7 CD cord-302953-gr2kk9w4 176 14 DPI DPI NNP cord-302953-gr2kk9w4 176 15 in in IN cord-302953-gr2kk9w4 176 16 WT WT NNP cord-302953-gr2kk9w4 176 17 and and CC cord-302953-gr2kk9w4 176 18 Ifng Ifng NNP cord-302953-gr2kk9w4 176 19 −/− −/− NNP cord-302953-gr2kk9w4 176 20 mice mouse NNS cord-302953-gr2kk9w4 176 21 and and CC cord-302953-gr2kk9w4 176 22 at at IN cord-302953-gr2kk9w4 176 23 5 5 CD cord-302953-gr2kk9w4 176 24 DPI DPI NNP cord-302953-gr2kk9w4 176 25 in in IN cord-302953-gr2kk9w4 176 26 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 176 27 −/− −/− NNP cord-302953-gr2kk9w4 176 28 mice mouse NNS cord-302953-gr2kk9w4 176 29 . . . cord-302953-gr2kk9w4 177 1 In in IN cord-302953-gr2kk9w4 177 2 both both DT cord-302953-gr2kk9w4 177 3 tissues tissue NNS cord-302953-gr2kk9w4 177 4 , , , cord-302953-gr2kk9w4 177 5 inflammation inflammation NN cord-302953-gr2kk9w4 177 6 scores score NNS cord-302953-gr2kk9w4 177 7 were be VBD cord-302953-gr2kk9w4 177 8 lower low JJR cord-302953-gr2kk9w4 177 9 in in IN cord-302953-gr2kk9w4 177 10 Ifng Ifng NNP cord-302953-gr2kk9w4 177 11 −/− −/− NNP cord-302953-gr2kk9w4 177 12 mice mouse NNS cord-302953-gr2kk9w4 177 13 than than IN cord-302953-gr2kk9w4 177 14 in in IN cord-302953-gr2kk9w4 177 15 WT WT NNP cord-302953-gr2kk9w4 177 16 or or CC cord-302953-gr2kk9w4 177 17 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 177 18 −/− −/− NNP cord-302953-gr2kk9w4 177 19 mice mouse NNS cord-302953-gr2kk9w4 177 20 . . . cord-302953-gr2kk9w4 178 1 Minimal minimal JJ cord-302953-gr2kk9w4 178 2 inflammation inflammation NN cord-302953-gr2kk9w4 178 3 present present JJ cord-302953-gr2kk9w4 178 4 in in IN cord-302953-gr2kk9w4 178 5 the the DT cord-302953-gr2kk9w4 178 6 brain brain NN cord-302953-gr2kk9w4 178 7 but but CC cord-302953-gr2kk9w4 178 8 not not RB cord-302953-gr2kk9w4 178 9 spinal spinal JJ cord-302953-gr2kk9w4 178 10 cord cord NN cord-302953-gr2kk9w4 178 11 of of IN cord-302953-gr2kk9w4 178 12 mock mock JJ cord-302953-gr2kk9w4 178 13 - - HYPH cord-302953-gr2kk9w4 178 14 infected infected JJ cord-302953-gr2kk9w4 178 15 mice mouse NNS cord-302953-gr2kk9w4 178 16 was be VBD cord-302953-gr2kk9w4 178 17 likely likely JJ cord-302953-gr2kk9w4 178 18 due due IN cord-302953-gr2kk9w4 178 19 to to IN cord-302953-gr2kk9w4 178 20 trauma trauma NN cord-302953-gr2kk9w4 178 21 from from IN cord-302953-gr2kk9w4 178 22 the the DT cord-302953-gr2kk9w4 178 23 IC IC NNP cord-302953-gr2kk9w4 178 24 inoculation inoculation NN cord-302953-gr2kk9w4 178 25 . . . cord-302953-gr2kk9w4 178 26 _SP cord-302953-gr2kk9w4 179 1 To to TO cord-302953-gr2kk9w4 179 2 examine examine VB cord-302953-gr2kk9w4 179 3 the the DT cord-302953-gr2kk9w4 179 4 effect effect NN cord-302953-gr2kk9w4 179 5 of of IN cord-302953-gr2kk9w4 179 6 IFN IFN NNP cord-302953-gr2kk9w4 179 7 - - HYPH cord-302953-gr2kk9w4 179 8 γ γ NNP cord-302953-gr2kk9w4 179 9 signaling signal VBG cord-302953-gr2kk9w4 179 10 on on IN cord-302953-gr2kk9w4 179 11 the the DT cord-302953-gr2kk9w4 179 12 inflammatory inflammatory JJ cord-302953-gr2kk9w4 179 13 response response NN cord-302953-gr2kk9w4 179 14 to to IN cord-302953-gr2kk9w4 179 15 SINV SINV NNP cord-302953-gr2kk9w4 179 16 infection infection NN cord-302953-gr2kk9w4 179 17 , , , cord-302953-gr2kk9w4 179 18 we -PRON- PRP cord-302953-gr2kk9w4 179 19 first first RB cord-302953-gr2kk9w4 179 20 examined examine VBD cord-302953-gr2kk9w4 179 21 brain brain NN cord-302953-gr2kk9w4 179 22 and and CC cord-302953-gr2kk9w4 179 23 spinal spinal JJ cord-302953-gr2kk9w4 179 24 cord cord NN cord-302953-gr2kk9w4 179 25 pathology pathology NN cord-302953-gr2kk9w4 179 26 of of IN cord-302953-gr2kk9w4 179 27 SINV SINV NNP cord-302953-gr2kk9w4 179 28 - - HYPH cord-302953-gr2kk9w4 179 29 infected infect VBN cord-302953-gr2kk9w4 179 30 WT WT NNP cord-302953-gr2kk9w4 179 31 , , , cord-302953-gr2kk9w4 179 32 Ifng Ifng NNP cord-302953-gr2kk9w4 179 33 −/− −/− NNP cord-302953-gr2kk9w4 179 34 and and CC cord-302953-gr2kk9w4 179 35 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 179 36 −/− −/− NNP cord-302953-gr2kk9w4 179 37 mice mouse NNS cord-302953-gr2kk9w4 179 38 . . . cord-302953-gr2kk9w4 180 1 Most Most JJS cord-302953-gr2kk9w4 180 2 of of IN cord-302953-gr2kk9w4 180 3 the the DT cord-302953-gr2kk9w4 180 4 pathological pathological JJ cord-302953-gr2kk9w4 180 5 changes change NNS cord-302953-gr2kk9w4 180 6 seen see VBN cord-302953-gr2kk9w4 180 7 with with IN cord-302953-gr2kk9w4 180 8 alphavirus alphavirus NNP cord-302953-gr2kk9w4 180 9 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 180 10 are be VBP cord-302953-gr2kk9w4 180 11 associated associate VBN cord-302953-gr2kk9w4 180 12 with with IN cord-302953-gr2kk9w4 180 13 infiltration infiltration NN cord-302953-gr2kk9w4 180 14 of of IN cord-302953-gr2kk9w4 180 15 immune immune JJ cord-302953-gr2kk9w4 180 16 cells cell NNS cord-302953-gr2kk9w4 180 17 [ [ -LRB- cord-302953-gr2kk9w4 180 18 14 14 CD cord-302953-gr2kk9w4 180 19 , , , cord-302953-gr2kk9w4 180 20 23 23 CD cord-302953-gr2kk9w4 180 21 , , , cord-302953-gr2kk9w4 180 22 24 24 CD cord-302953-gr2kk9w4 180 23 , , , cord-302953-gr2kk9w4 180 24 [ [ -LRB- cord-302953-gr2kk9w4 180 25 31 31 CD cord-302953-gr2kk9w4 180 26 ] ] -RRB- cord-302953-gr2kk9w4 180 27 [ [ -LRB- cord-302953-gr2kk9w4 180 28 32 32 CD cord-302953-gr2kk9w4 180 29 ] ] -RRB- cord-302953-gr2kk9w4 180 30 [ [ -LRB- cord-302953-gr2kk9w4 180 31 33 33 CD cord-302953-gr2kk9w4 180 32 ] ] -RRB- cord-302953-gr2kk9w4 180 33 . . . cord-302953-gr2kk9w4 181 1 Brains brain NNS cord-302953-gr2kk9w4 181 2 and and CC cord-302953-gr2kk9w4 181 3 spinal spinal JJ cord-302953-gr2kk9w4 181 4 cords cord NNS cord-302953-gr2kk9w4 181 5 were be VBD cord-302953-gr2kk9w4 181 6 examined examine VBN cord-302953-gr2kk9w4 181 7 for for IN cord-302953-gr2kk9w4 181 8 histopathological histopathological JJ cord-302953-gr2kk9w4 181 9 changes change NNS cord-302953-gr2kk9w4 181 10 and and CC cord-302953-gr2kk9w4 181 11 inflammation inflammation NN cord-302953-gr2kk9w4 181 12 at at IN cord-302953-gr2kk9w4 181 13 0 0 CD cord-302953-gr2kk9w4 181 14 , , , cord-302953-gr2kk9w4 181 15 3 3 CD cord-302953-gr2kk9w4 181 16 , , , cord-302953-gr2kk9w4 181 17 5 5 CD cord-302953-gr2kk9w4 181 18 , , , cord-302953-gr2kk9w4 181 19 and and CC cord-302953-gr2kk9w4 181 20 7 7 CD cord-302953-gr2kk9w4 181 21 DPI DPI NNP cord-302953-gr2kk9w4 181 22 ( ( -LRB- cord-302953-gr2kk9w4 181 23 Figure Figure NNP cord-302953-gr2kk9w4 181 24 6 6 CD cord-302953-gr2kk9w4 181 25 ) ) -RRB- cord-302953-gr2kk9w4 181 26 . . . cord-302953-gr2kk9w4 182 1 Sporadically sporadically RB cord-302953-gr2kk9w4 182 2 at at IN cord-302953-gr2kk9w4 182 3 5 5 CD cord-302953-gr2kk9w4 182 4 DPI DPI NNP cord-302953-gr2kk9w4 182 5 and and CC cord-302953-gr2kk9w4 182 6 consistently consistently RB cord-302953-gr2kk9w4 182 7 at at IN cord-302953-gr2kk9w4 182 8 7 7 CD cord-302953-gr2kk9w4 182 9 DPI DPI NNP cord-302953-gr2kk9w4 182 10 , , , cord-302953-gr2kk9w4 182 11 brains brain NNS cord-302953-gr2kk9w4 182 12 from from IN cord-302953-gr2kk9w4 182 13 WT WT NNP cord-302953-gr2kk9w4 182 14 mice mouse NNS cord-302953-gr2kk9w4 182 15 had have VBD cord-302953-gr2kk9w4 182 16 diffuse diffuse JJ cord-302953-gr2kk9w4 182 17 bilateral bilateral JJ cord-302953-gr2kk9w4 182 18 dilation dilation NN cord-302953-gr2kk9w4 182 19 of of IN cord-302953-gr2kk9w4 182 20 the the DT cord-302953-gr2kk9w4 182 21 lateral lateral JJ cord-302953-gr2kk9w4 182 22 ventricles ventricle NNS cord-302953-gr2kk9w4 182 23 , , , cord-302953-gr2kk9w4 182 24 extending extend VBG cord-302953-gr2kk9w4 182 25 along along IN cord-302953-gr2kk9w4 182 26 the the DT cord-302953-gr2kk9w4 182 27 dorsal dorsal JJ cord-302953-gr2kk9w4 182 28 aspects aspect NNS cord-302953-gr2kk9w4 182 29 of of IN cord-302953-gr2kk9w4 182 30 the the DT cord-302953-gr2kk9w4 182 31 hippocampi hippocampus NNS cord-302953-gr2kk9w4 182 32 . . . cord-302953-gr2kk9w4 183 1 This this DT cord-302953-gr2kk9w4 183 2 change change NN cord-302953-gr2kk9w4 183 3 was be VBD cord-302953-gr2kk9w4 183 4 rarely rarely RB cord-302953-gr2kk9w4 183 5 seen see VBN cord-302953-gr2kk9w4 183 6 in in IN cord-302953-gr2kk9w4 183 7 brains brain NNS cord-302953-gr2kk9w4 183 8 from from IN cord-302953-gr2kk9w4 183 9 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 183 10 −/− −/− NNP cord-302953-gr2kk9w4 183 11 or or CC cord-302953-gr2kk9w4 183 12 Ifng Ifng NNP cord-302953-gr2kk9w4 183 13 −/− −/− NNP cord-302953-gr2kk9w4 183 14 mice mouse NNS cord-302953-gr2kk9w4 183 15 , , , cord-302953-gr2kk9w4 183 16 and and CC cord-302953-gr2kk9w4 183 17 when when WRB cord-302953-gr2kk9w4 183 18 present present JJ cord-302953-gr2kk9w4 183 19 , , , cord-302953-gr2kk9w4 183 20 was be VBD cord-302953-gr2kk9w4 183 21 less less RBR cord-302953-gr2kk9w4 183 22 severe severe JJ cord-302953-gr2kk9w4 183 23 . . . cord-302953-gr2kk9w4 184 1 Compared compare VBN cord-302953-gr2kk9w4 184 2 to to TO cord-302953-gr2kk9w4 184 3 mock mock VB cord-302953-gr2kk9w4 184 4 - - HYPH cord-302953-gr2kk9w4 184 5 infected infected JJ cord-302953-gr2kk9w4 184 6 control control NN cord-302953-gr2kk9w4 184 7 mice mouse NNS cord-302953-gr2kk9w4 184 8 ( ( -LRB- cord-302953-gr2kk9w4 184 9 Figure figure NN cord-302953-gr2kk9w4 184 10 6A 6a CD cord-302953-gr2kk9w4 184 11 ) ) -RRB- cord-302953-gr2kk9w4 184 12 , , , cord-302953-gr2kk9w4 184 13 both both DT cord-302953-gr2kk9w4 184 14 perivascular perivascular JJ cord-302953-gr2kk9w4 184 15 cuffing cuffing NN cord-302953-gr2kk9w4 184 16 and and CC cord-302953-gr2kk9w4 184 17 infiltration infiltration NN cord-302953-gr2kk9w4 184 18 of of IN cord-302953-gr2kk9w4 184 19 mononuclear mononuclear JJ cord-302953-gr2kk9w4 184 20 cells cell NNS cord-302953-gr2kk9w4 184 21 into into IN cord-302953-gr2kk9w4 184 22 the the DT cord-302953-gr2kk9w4 184 23 parenchyma parenchyma NN cord-302953-gr2kk9w4 184 24 in in IN cord-302953-gr2kk9w4 184 25 the the DT cord-302953-gr2kk9w4 184 26 brain brain NN cord-302953-gr2kk9w4 184 27 were be VBD cord-302953-gr2kk9w4 184 28 present present JJ cord-302953-gr2kk9w4 184 29 at at IN cord-302953-gr2kk9w4 184 30 7 7 CD cord-302953-gr2kk9w4 184 31 DPI DPI NNP cord-302953-gr2kk9w4 184 32 in in IN cord-302953-gr2kk9w4 184 33 all all DT cord-302953-gr2kk9w4 184 34 SINV SINV NNP cord-302953-gr2kk9w4 184 35 - - HYPH cord-302953-gr2kk9w4 184 36 infected infect VBN cord-302953-gr2kk9w4 184 37 mice mouse NNS cord-302953-gr2kk9w4 184 38 ( ( -LRB- cord-302953-gr2kk9w4 184 39 Figure figure NN cord-302953-gr2kk9w4 184 40 6B 6b NN cord-302953-gr2kk9w4 184 41 ) ) -RRB- cord-302953-gr2kk9w4 184 42 . . . cord-302953-gr2kk9w4 185 1 In in IN cord-302953-gr2kk9w4 185 2 the the DT cord-302953-gr2kk9w4 185 3 spinal spinal JJ cord-302953-gr2kk9w4 185 4 cord cord NN cord-302953-gr2kk9w4 185 5 , , , cord-302953-gr2kk9w4 185 6 compared compare VBN cord-302953-gr2kk9w4 185 7 to to IN cord-302953-gr2kk9w4 185 8 mock mock VB cord-302953-gr2kk9w4 185 9 - - HYPH cord-302953-gr2kk9w4 185 10 infected infect VBN cord-302953-gr2kk9w4 185 11 controls control NNS cord-302953-gr2kk9w4 185 12 ( ( -LRB- cord-302953-gr2kk9w4 185 13 Figure figure NN cord-302953-gr2kk9w4 185 14 6C 6c NN cord-302953-gr2kk9w4 185 15 ) ) -RRB- cord-302953-gr2kk9w4 185 16 , , , cord-302953-gr2kk9w4 185 17 SINV SINV NNP cord-302953-gr2kk9w4 185 18 - - HYPH cord-302953-gr2kk9w4 185 19 infected infect VBN cord-302953-gr2kk9w4 185 20 WT WT NNP cord-302953-gr2kk9w4 185 21 and and CC cord-302953-gr2kk9w4 185 22 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 186 1 −/− −/− NNP cord-302953-gr2kk9w4 186 2 mice mouse NNS cord-302953-gr2kk9w4 186 3 had have VBD cord-302953-gr2kk9w4 186 4 more more JJR cord-302953-gr2kk9w4 186 5 inflammation inflammation NN cord-302953-gr2kk9w4 186 6 than than IN cord-302953-gr2kk9w4 186 7 Ifng Ifng NNP cord-302953-gr2kk9w4 186 8 −/− −/− NNP cord-302953-gr2kk9w4 186 9 mice mouse NNS cord-302953-gr2kk9w4 186 10 ( ( -LRB- cord-302953-gr2kk9w4 186 11 Figure figure NN cord-302953-gr2kk9w4 186 12 6D 6d NN cord-302953-gr2kk9w4 186 13 ) ) -RRB- cord-302953-gr2kk9w4 186 14 . . . cord-302953-gr2kk9w4 187 1 For for IN cord-302953-gr2kk9w4 187 2 quantitative quantitative JJ cord-302953-gr2kk9w4 187 3 comparison comparison NN cord-302953-gr2kk9w4 187 4 of of IN cord-302953-gr2kk9w4 187 5 the the DT cord-302953-gr2kk9w4 187 6 inflammation inflammation NN cord-302953-gr2kk9w4 187 7 in in IN cord-302953-gr2kk9w4 187 8 brain brain NN cord-302953-gr2kk9w4 187 9 ( ( -LRB- cord-302953-gr2kk9w4 187 10 Figure Figure NNP cord-302953-gr2kk9w4 187 11 6E 6E NNP cord-302953-gr2kk9w4 187 12 ) ) -RRB- cord-302953-gr2kk9w4 187 13 and and CC cord-302953-gr2kk9w4 187 14 spinal spinal JJ cord-302953-gr2kk9w4 187 15 cord cord NN cord-302953-gr2kk9w4 187 16 ( ( -LRB- cord-302953-gr2kk9w4 187 17 Figure figure NN cord-302953-gr2kk9w4 187 18 6F 6f NN cord-302953-gr2kk9w4 187 19 ) ) -RRB- cord-302953-gr2kk9w4 187 20 at at IN cord-302953-gr2kk9w4 187 21 3 3 CD cord-302953-gr2kk9w4 187 22 , , , cord-302953-gr2kk9w4 187 23 5 5 CD cord-302953-gr2kk9w4 187 24 , , , cord-302953-gr2kk9w4 187 25 and and CC cord-302953-gr2kk9w4 187 26 7 7 CD cord-302953-gr2kk9w4 187 27 DPI DPI NNP cord-302953-gr2kk9w4 187 28 , , , cord-302953-gr2kk9w4 187 29 a a DT cord-302953-gr2kk9w4 187 30 scoring scoring NN cord-302953-gr2kk9w4 187 31 system system NN cord-302953-gr2kk9w4 187 32 was be VBD cord-302953-gr2kk9w4 187 33 used use VBN cord-302953-gr2kk9w4 187 34 to to TO cord-302953-gr2kk9w4 187 35 evaluate evaluate VB cord-302953-gr2kk9w4 187 36 coded code VBN cord-302953-gr2kk9w4 187 37 H&E H&E NNP cord-302953-gr2kk9w4 187 38 - - HYPH cord-302953-gr2kk9w4 187 39 stained stain VBN cord-302953-gr2kk9w4 187 40 sections section NNS cord-302953-gr2kk9w4 187 41 [ [ -LRB- cord-302953-gr2kk9w4 187 42 23 23 CD cord-302953-gr2kk9w4 187 43 , , , cord-302953-gr2kk9w4 187 44 24 24 CD cord-302953-gr2kk9w4 187 45 ] ] -RRB- cord-302953-gr2kk9w4 187 46 . . . cord-302953-gr2kk9w4 188 1 Inflammation inflammation NN cord-302953-gr2kk9w4 188 2 steadily steadily RB cord-302953-gr2kk9w4 188 3 increased increase VBD cord-302953-gr2kk9w4 188 4 during during IN cord-302953-gr2kk9w4 188 5 the the DT cord-302953-gr2kk9w4 188 6 first first JJ cord-302953-gr2kk9w4 188 7 week week NN cord-302953-gr2kk9w4 188 8 of of IN cord-302953-gr2kk9w4 188 9 infection infection NN cord-302953-gr2kk9w4 188 10 , , , cord-302953-gr2kk9w4 188 11 peaking peak VBG cord-302953-gr2kk9w4 188 12 at at IN cord-302953-gr2kk9w4 188 13 7 7 CD cord-302953-gr2kk9w4 188 14 DPI DPI NNP cord-302953-gr2kk9w4 188 15 in in IN cord-302953-gr2kk9w4 188 16 WT WT NNP cord-302953-gr2kk9w4 188 17 and and CC cord-302953-gr2kk9w4 188 18 Ifng Ifng NNP cord-302953-gr2kk9w4 188 19 −/− −/− NNP cord-302953-gr2kk9w4 188 20 mice mouse NNS cord-302953-gr2kk9w4 188 21 and and CC cord-302953-gr2kk9w4 188 22 at at IN cord-302953-gr2kk9w4 188 23 5 5 CD cord-302953-gr2kk9w4 188 24 DPI DPI NNP cord-302953-gr2kk9w4 188 25 in in IN cord-302953-gr2kk9w4 188 26 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 188 27 −/− −/− NNP cord-302953-gr2kk9w4 188 28 mice mouse NNS cord-302953-gr2kk9w4 188 29 . . . cord-302953-gr2kk9w4 189 1 In in IN cord-302953-gr2kk9w4 189 2 both both DT cord-302953-gr2kk9w4 189 3 tissues tissue NNS cord-302953-gr2kk9w4 189 4 , , , cord-302953-gr2kk9w4 189 5 inflammation inflammation NN cord-302953-gr2kk9w4 189 6 scores score NNS cord-302953-gr2kk9w4 189 7 were be VBD cord-302953-gr2kk9w4 189 8 lower low JJR cord-302953-gr2kk9w4 189 9 in in IN cord-302953-gr2kk9w4 189 10 Ifng Ifng NNP cord-302953-gr2kk9w4 189 11 −/− −/− NNP cord-302953-gr2kk9w4 189 12 mice mouse NNS cord-302953-gr2kk9w4 189 13 than than IN cord-302953-gr2kk9w4 189 14 in in IN cord-302953-gr2kk9w4 189 15 WT WT NNP cord-302953-gr2kk9w4 189 16 or or CC cord-302953-gr2kk9w4 189 17 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 189 18 −/− −/− NNP cord-302953-gr2kk9w4 189 19 mice mouse NNS cord-302953-gr2kk9w4 189 20 . . . cord-302953-gr2kk9w4 190 1 Minimal minimal JJ cord-302953-gr2kk9w4 190 2 inflammation inflammation NN cord-302953-gr2kk9w4 190 3 present present JJ cord-302953-gr2kk9w4 190 4 in in IN cord-302953-gr2kk9w4 190 5 the the DT cord-302953-gr2kk9w4 190 6 brain brain NN cord-302953-gr2kk9w4 190 7 but but CC cord-302953-gr2kk9w4 190 8 not not RB cord-302953-gr2kk9w4 190 9 spinal spinal JJ cord-302953-gr2kk9w4 190 10 cord cord NN cord-302953-gr2kk9w4 190 11 of of IN cord-302953-gr2kk9w4 190 12 mock mock JJ cord-302953-gr2kk9w4 190 13 - - HYPH cord-302953-gr2kk9w4 190 14 infected infected JJ cord-302953-gr2kk9w4 190 15 mice mouse NNS cord-302953-gr2kk9w4 190 16 was be VBD cord-302953-gr2kk9w4 190 17 likely likely JJ cord-302953-gr2kk9w4 190 18 due due IN cord-302953-gr2kk9w4 190 19 to to IN cord-302953-gr2kk9w4 190 20 trauma trauma NN cord-302953-gr2kk9w4 190 21 from from IN cord-302953-gr2kk9w4 190 22 the the DT cord-302953-gr2kk9w4 190 23 IC IC NNP cord-302953-gr2kk9w4 190 24 inoculation inoculation NN cord-302953-gr2kk9w4 190 25 . . . cord-302953-gr2kk9w4 191 1 , , , cord-302953-gr2kk9w4 191 2 and and CC cord-302953-gr2kk9w4 191 3 Ifng Ifng NNP cord-302953-gr2kk9w4 191 4 −/− −/− NNP cord-302953-gr2kk9w4 191 5 ( ( -LRB- cord-302953-gr2kk9w4 191 6 white white JJ cord-302953-gr2kk9w4 191 7 bars bar NNS cord-302953-gr2kk9w4 191 8 ) ) -RRB- cord-302953-gr2kk9w4 191 9 mice mouse NNS cord-302953-gr2kk9w4 192 1 either either CC cord-302953-gr2kk9w4 192 2 mock mock NN cord-302953-gr2kk9w4 192 3 - - HYPH cord-302953-gr2kk9w4 192 4 infected infect VBN cord-302953-gr2kk9w4 192 5 or or CC cord-302953-gr2kk9w4 192 6 SINV sinv NN cord-302953-gr2kk9w4 192 7 - - HYPH cord-302953-gr2kk9w4 192 8 infected infect VBN cord-302953-gr2kk9w4 192 9 at at IN cord-302953-gr2kk9w4 192 10 3 3 CD cord-302953-gr2kk9w4 192 11 , , , cord-302953-gr2kk9w4 192 12 5 5 CD cord-302953-gr2kk9w4 192 13 or or CC cord-302953-gr2kk9w4 192 14 7 7 CD cord-302953-gr2kk9w4 192 15 DPI DPI NNP cord-302953-gr2kk9w4 192 16 were be VBD cord-302953-gr2kk9w4 192 17 scored score VBN cord-302953-gr2kk9w4 192 18 for for IN cord-302953-gr2kk9w4 192 19 inflammation inflammation NN cord-302953-gr2kk9w4 192 20 using use VBG cord-302953-gr2kk9w4 192 21 a a DT cord-302953-gr2kk9w4 192 22 four four CD cord-302953-gr2kk9w4 192 23 - - HYPH cord-302953-gr2kk9w4 192 24 point point NN cord-302953-gr2kk9w4 192 25 ( ( -LRB- cord-302953-gr2kk9w4 192 26 brain brain NN cord-302953-gr2kk9w4 192 27 ) ) -RRB- cord-302953-gr2kk9w4 192 28 or or CC cord-302953-gr2kk9w4 192 29 three three CD cord-302953-gr2kk9w4 192 30 - - HYPH cord-302953-gr2kk9w4 192 31 point point NN cord-302953-gr2kk9w4 192 32 ( ( -LRB- cord-302953-gr2kk9w4 192 33 spinal spinal JJ cord-302953-gr2kk9w4 192 34 cord cord NN cord-302953-gr2kk9w4 192 35 ) ) -RRB- cord-302953-gr2kk9w4 192 36 system system NN cord-302953-gr2kk9w4 192 37 ( ( -LRB- cord-302953-gr2kk9w4 192 38 data datum NNS cord-302953-gr2kk9w4 192 39 are be VBP cord-302953-gr2kk9w4 192 40 presented present VBN cord-302953-gr2kk9w4 192 41 as as IN cord-302953-gr2kk9w4 192 42 the the DT cord-302953-gr2kk9w4 192 43 mean mean NN cord-302953-gr2kk9w4 192 44 score score NN cord-302953-gr2kk9w4 192 45 ± ± NNP cord-302953-gr2kk9w4 192 46 SEM SEM NNP cord-302953-gr2kk9w4 192 47 for for IN cord-302953-gr2kk9w4 192 48 3 3 CD cord-302953-gr2kk9w4 192 49 - - SYM cord-302953-gr2kk9w4 192 50 4 4 CD cord-302953-gr2kk9w4 192 51 mice mouse NNS cord-302953-gr2kk9w4 192 52 per per IN cord-302953-gr2kk9w4 192 53 strain strain NN cord-302953-gr2kk9w4 192 54 per per IN cord-302953-gr2kk9w4 192 55 group group NN cord-302953-gr2kk9w4 192 56 ; ; : cord-302953-gr2kk9w4 193 1 * * NFP cord-302953-gr2kk9w4 193 2 p p XX cord-302953-gr2kk9w4 193 3 < < XX cord-302953-gr2kk9w4 193 4 0.05 0.05 CD cord-302953-gr2kk9w4 193 5 and and CC cord-302953-gr2kk9w4 194 1 * * NFP cord-302953-gr2kk9w4 194 2 * * NFP cord-302953-gr2kk9w4 194 3 p p XX cord-302953-gr2kk9w4 194 4 < < XX cord-302953-gr2kk9w4 194 5 0.01 0.01 CD cord-302953-gr2kk9w4 194 6 , , , cord-302953-gr2kk9w4 194 7 Tukey Tukey NNP cord-302953-gr2kk9w4 194 8 's 's POS cord-302953-gr2kk9w4 194 9 multiple multiple JJ cord-302953-gr2kk9w4 194 10 comparisons comparison NNS cord-302953-gr2kk9w4 194 11 test test VBP cord-302953-gr2kk9w4 194 12 ) ) -RRB- cord-302953-gr2kk9w4 194 13 . . . cord-302953-gr2kk9w4 195 1 To to TO cord-302953-gr2kk9w4 195 2 determine determine VB cord-302953-gr2kk9w4 195 3 the the DT cord-302953-gr2kk9w4 195 4 effects effect NNS cord-302953-gr2kk9w4 195 5 of of IN cord-302953-gr2kk9w4 195 6 IFN IFN NNP cord-302953-gr2kk9w4 195 7 - - HYPH cord-302953-gr2kk9w4 195 8 γ γ NNP cord-302953-gr2kk9w4 195 9 signaling signal VBG cord-302953-gr2kk9w4 195 10 on on IN cord-302953-gr2kk9w4 195 11 immune immune JJ cord-302953-gr2kk9w4 195 12 cell cell NN cord-302953-gr2kk9w4 195 13 subsets subset NNS cord-302953-gr2kk9w4 195 14 after after IN cord-302953-gr2kk9w4 195 15 SINV SINV NNP cord-302953-gr2kk9w4 195 16 infection infection NN cord-302953-gr2kk9w4 195 17 , , , cord-302953-gr2kk9w4 195 18 cells cell NNS cord-302953-gr2kk9w4 195 19 isolated isolate VBN cord-302953-gr2kk9w4 195 20 from from IN cord-302953-gr2kk9w4 195 21 the the DT cord-302953-gr2kk9w4 195 22 CLNs cln NNS cord-302953-gr2kk9w4 195 23 and and CC cord-302953-gr2kk9w4 195 24 brains brain NNS cord-302953-gr2kk9w4 195 25 of of IN cord-302953-gr2kk9w4 195 26 WT WT NNP cord-302953-gr2kk9w4 195 27 , , , cord-302953-gr2kk9w4 195 28 Ifng Ifng NNP cord-302953-gr2kk9w4 195 29 −/− −/− NNP cord-302953-gr2kk9w4 195 30 and and CC cord-302953-gr2kk9w4 195 31 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 195 32 −/− −/− NNP cord-302953-gr2kk9w4 195 33 mice mouse NNS cord-302953-gr2kk9w4 195 34 were be VBD cord-302953-gr2kk9w4 195 35 examined examine VBN cord-302953-gr2kk9w4 195 36 by by IN cord-302953-gr2kk9w4 195 37 flow flow NN cord-302953-gr2kk9w4 195 38 cytometry cytometry NN cord-302953-gr2kk9w4 195 39 . . . cord-302953-gr2kk9w4 196 1 In in IN cord-302953-gr2kk9w4 196 2 the the DT cord-302953-gr2kk9w4 196 3 CLNs cln NNS cord-302953-gr2kk9w4 196 4 at at IN cord-302953-gr2kk9w4 196 5 5 5 CD cord-302953-gr2kk9w4 196 6 DPI DPI NNP cord-302953-gr2kk9w4 196 7 , , , cord-302953-gr2kk9w4 196 8 there there EX cord-302953-gr2kk9w4 196 9 were be VBD cord-302953-gr2kk9w4 196 10 more more RBR cord-302953-gr2kk9w4 196 11 total total JJ cord-302953-gr2kk9w4 196 12 mononuclear mononuclear JJ cord-302953-gr2kk9w4 196 13 cells cell NNS cord-302953-gr2kk9w4 196 14 in in IN cord-302953-gr2kk9w4 196 15 WT WT NNP cord-302953-gr2kk9w4 196 16 mice mouse NNS cord-302953-gr2kk9w4 196 17 than than IN cord-302953-gr2kk9w4 196 18 Ifng Ifng NNP cord-302953-gr2kk9w4 196 19 −/− −/− NNP cord-302953-gr2kk9w4 196 20 mice mouse NNS cord-302953-gr2kk9w4 196 21 ( ( -LRB- cord-302953-gr2kk9w4 196 22 Figure figure VB cord-302953-gr2kk9w4 196 23 _SP cord-302953-gr2kk9w4 196 24 7A 7a NN cord-302953-gr2kk9w4 196 25 ) ) -RRB- cord-302953-gr2kk9w4 196 26 , , , cord-302953-gr2kk9w4 196 27 but but CC cord-302953-gr2kk9w4 196 28 similar similar JJ cord-302953-gr2kk9w4 196 29 numbers number NNS cord-302953-gr2kk9w4 196 30 at at IN cord-302953-gr2kk9w4 196 31 7 7 CD cord-302953-gr2kk9w4 196 32 and and CC cord-302953-gr2kk9w4 196 33 10 10 CD cord-302953-gr2kk9w4 196 34 DPI DPI NNP cord-302953-gr2kk9w4 196 35 . . . cord-302953-gr2kk9w4 197 1 Neither neither CC cord-302953-gr2kk9w4 197 2 the the DT cord-302953-gr2kk9w4 197 3 percentage percentage NN cord-302953-gr2kk9w4 197 4 nor nor CC cord-302953-gr2kk9w4 197 5 absolute absolute JJ cord-302953-gr2kk9w4 197 6 number number NN cord-302953-gr2kk9w4 197 7 of of IN cord-302953-gr2kk9w4 197 8 CD4 CD4 NNP cord-302953-gr2kk9w4 197 9 + + CC cord-302953-gr2kk9w4 197 10 T t NN cord-302953-gr2kk9w4 197 11 cells cell NNS cord-302953-gr2kk9w4 197 12 ( ( -LRB- cord-302953-gr2kk9w4 197 13 Figure Figure NNP cord-302953-gr2kk9w4 197 14 7C 7C NNP cord-302953-gr2kk9w4 197 15 ) ) -RRB- cord-302953-gr2kk9w4 197 16 or or CC cord-302953-gr2kk9w4 197 17 CD8 CD8 NNP cord-302953-gr2kk9w4 197 18 + + CC cord-302953-gr2kk9w4 197 19 T T NNP cord-302953-gr2kk9w4 197 20 cells cell NNS cord-302953-gr2kk9w4 197 21 ( ( -LRB- cord-302953-gr2kk9w4 197 22 Figure Figure NNP cord-302953-gr2kk9w4 197 23 7D 7D NNP cord-302953-gr2kk9w4 197 24 ) ) -RRB- cord-302953-gr2kk9w4 197 25 in in IN cord-302953-gr2kk9w4 197 26 CLNs cln NNS cord-302953-gr2kk9w4 197 27 were be VBD cord-302953-gr2kk9w4 197 28 affected affect VBN cord-302953-gr2kk9w4 197 29 by by IN cord-302953-gr2kk9w4 197 30 impaired impaired JJ cord-302953-gr2kk9w4 197 31 IFN IFN NNP cord-302953-gr2kk9w4 197 32 - - HYPH cord-302953-gr2kk9w4 197 33 γ γ NNP cord-302953-gr2kk9w4 197 34 signaling signaling NN cord-302953-gr2kk9w4 197 35 , , , cord-302953-gr2kk9w4 197 36 with with IN cord-302953-gr2kk9w4 197 37 a a DT cord-302953-gr2kk9w4 197 38 general general JJ cord-302953-gr2kk9w4 197 39 overall overall JJ cord-302953-gr2kk9w4 197 40 decrease decrease NN cord-302953-gr2kk9w4 197 41 from from IN cord-302953-gr2kk9w4 197 42 5 5 CD cord-302953-gr2kk9w4 197 43 DPI DPI NNP cord-302953-gr2kk9w4 197 44 to to IN cord-302953-gr2kk9w4 197 45 10 10 CD cord-302953-gr2kk9w4 197 46 DPI DPI NNP cord-302953-gr2kk9w4 197 47 . . NNP cord-302953-gr2kk9w4 197 48 , , , cord-302953-gr2kk9w4 197 49 and and CC cord-302953-gr2kk9w4 197 50 Ifng Ifng NNP cord-302953-gr2kk9w4 197 51 −/− −/− NNP cord-302953-gr2kk9w4 197 52 ( ( -LRB- cord-302953-gr2kk9w4 197 53 white white JJ cord-302953-gr2kk9w4 197 54 bars bar NNS cord-302953-gr2kk9w4 197 55 ) ) -RRB- cord-302953-gr2kk9w4 197 56 mice mouse NNS cord-302953-gr2kk9w4 197 57 either either CC cord-302953-gr2kk9w4 197 58 mock mock NN cord-302953-gr2kk9w4 197 59 - - HYPH cord-302953-gr2kk9w4 197 60 infected infect VBN cord-302953-gr2kk9w4 197 61 or or CC cord-302953-gr2kk9w4 197 62 SINV sinv NN cord-302953-gr2kk9w4 197 63 - - HYPH cord-302953-gr2kk9w4 197 64 infected infect VBN cord-302953-gr2kk9w4 197 65 at at IN cord-302953-gr2kk9w4 197 66 3 3 CD cord-302953-gr2kk9w4 197 67 , , , cord-302953-gr2kk9w4 197 68 5 5 CD cord-302953-gr2kk9w4 197 69 or or CC cord-302953-gr2kk9w4 197 70 7 7 CD cord-302953-gr2kk9w4 197 71 DPI DPI NNP cord-302953-gr2kk9w4 197 72 were be VBD cord-302953-gr2kk9w4 197 73 scored score VBN cord-302953-gr2kk9w4 197 74 for for IN cord-302953-gr2kk9w4 197 75 inflammation inflammation NN cord-302953-gr2kk9w4 197 76 using use VBG cord-302953-gr2kk9w4 197 77 a a DT cord-302953-gr2kk9w4 197 78 four four CD cord-302953-gr2kk9w4 197 79 - - HYPH cord-302953-gr2kk9w4 197 80 point point NN cord-302953-gr2kk9w4 197 81 ( ( -LRB- cord-302953-gr2kk9w4 197 82 brain brain NN cord-302953-gr2kk9w4 197 83 ) ) -RRB- cord-302953-gr2kk9w4 197 84 or or CC cord-302953-gr2kk9w4 197 85 three three CD cord-302953-gr2kk9w4 197 86 - - HYPH cord-302953-gr2kk9w4 197 87 point point NN cord-302953-gr2kk9w4 197 88 ( ( -LRB- cord-302953-gr2kk9w4 197 89 spinal spinal JJ cord-302953-gr2kk9w4 197 90 cord cord NN cord-302953-gr2kk9w4 197 91 ) ) -RRB- cord-302953-gr2kk9w4 197 92 system system NN cord-302953-gr2kk9w4 197 93 ( ( -LRB- cord-302953-gr2kk9w4 197 94 data datum NNS cord-302953-gr2kk9w4 197 95 are be VBP cord-302953-gr2kk9w4 197 96 presented present VBN cord-302953-gr2kk9w4 197 97 as as IN cord-302953-gr2kk9w4 197 98 the the DT cord-302953-gr2kk9w4 197 99 mean mean NN cord-302953-gr2kk9w4 197 100 score score NN cord-302953-gr2kk9w4 197 101 ± ± NNP cord-302953-gr2kk9w4 197 102 SEM SEM NNP cord-302953-gr2kk9w4 197 103 for for IN cord-302953-gr2kk9w4 197 104 3 3 CD cord-302953-gr2kk9w4 197 105 - - SYM cord-302953-gr2kk9w4 197 106 4 4 CD cord-302953-gr2kk9w4 197 107 mice mouse NNS cord-302953-gr2kk9w4 197 108 per per IN cord-302953-gr2kk9w4 197 109 strain strain NN cord-302953-gr2kk9w4 197 110 per per IN cord-302953-gr2kk9w4 197 111 group group NN cord-302953-gr2kk9w4 197 112 ; ; : cord-302953-gr2kk9w4 198 1 * * NFP cord-302953-gr2kk9w4 198 2 p p XX cord-302953-gr2kk9w4 198 3 < < XX cord-302953-gr2kk9w4 198 4 0.05 0.05 CD cord-302953-gr2kk9w4 198 5 and and CC cord-302953-gr2kk9w4 199 1 * * NFP cord-302953-gr2kk9w4 199 2 * * NFP cord-302953-gr2kk9w4 199 3 p p XX cord-302953-gr2kk9w4 199 4 < < XX cord-302953-gr2kk9w4 199 5 0.01 0.01 CD cord-302953-gr2kk9w4 199 6 , , , cord-302953-gr2kk9w4 199 7 Tukey Tukey NNP cord-302953-gr2kk9w4 199 8 's 's POS cord-302953-gr2kk9w4 199 9 multiple multiple JJ cord-302953-gr2kk9w4 199 10 comparisons comparison NNS cord-302953-gr2kk9w4 199 11 test test VBP cord-302953-gr2kk9w4 199 12 ) ) -RRB- cord-302953-gr2kk9w4 199 13 . . . cord-302953-gr2kk9w4 200 1 To to TO cord-302953-gr2kk9w4 200 2 determine determine VB cord-302953-gr2kk9w4 200 3 the the DT cord-302953-gr2kk9w4 200 4 effects effect NNS cord-302953-gr2kk9w4 200 5 of of IN cord-302953-gr2kk9w4 200 6 IFN IFN NNP cord-302953-gr2kk9w4 200 7 - - HYPH cord-302953-gr2kk9w4 200 8 γ γ NNP cord-302953-gr2kk9w4 200 9 signaling signal VBG cord-302953-gr2kk9w4 200 10 on on IN cord-302953-gr2kk9w4 200 11 immune immune JJ cord-302953-gr2kk9w4 200 12 cell cell NN cord-302953-gr2kk9w4 200 13 subsets subset NNS cord-302953-gr2kk9w4 200 14 after after IN cord-302953-gr2kk9w4 200 15 SINV SINV NNP cord-302953-gr2kk9w4 200 16 infection infection NN cord-302953-gr2kk9w4 200 17 , , , cord-302953-gr2kk9w4 200 18 cells cell NNS cord-302953-gr2kk9w4 200 19 isolated isolate VBN cord-302953-gr2kk9w4 200 20 from from IN cord-302953-gr2kk9w4 200 21 the the DT cord-302953-gr2kk9w4 200 22 CLNs cln NNS cord-302953-gr2kk9w4 200 23 and and CC cord-302953-gr2kk9w4 200 24 brains brain NNS cord-302953-gr2kk9w4 200 25 of of IN cord-302953-gr2kk9w4 200 26 WT WT NNP cord-302953-gr2kk9w4 200 27 , , , cord-302953-gr2kk9w4 200 28 Ifng Ifng NNP cord-302953-gr2kk9w4 200 29 −/− −/− NNP cord-302953-gr2kk9w4 200 30 and and CC cord-302953-gr2kk9w4 200 31 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 200 32 −/− −/− NNP cord-302953-gr2kk9w4 200 33 mice mouse NNS cord-302953-gr2kk9w4 200 34 were be VBD cord-302953-gr2kk9w4 200 35 examined examine VBN cord-302953-gr2kk9w4 200 36 by by IN cord-302953-gr2kk9w4 200 37 flow flow NN cord-302953-gr2kk9w4 200 38 cytometry cytometry NN cord-302953-gr2kk9w4 200 39 . . . cord-302953-gr2kk9w4 201 1 In in IN cord-302953-gr2kk9w4 201 2 the the DT cord-302953-gr2kk9w4 201 3 CLNs cln NNS cord-302953-gr2kk9w4 201 4 at at IN cord-302953-gr2kk9w4 201 5 5 5 CD cord-302953-gr2kk9w4 201 6 DPI DPI NNP cord-302953-gr2kk9w4 201 7 , , , cord-302953-gr2kk9w4 201 8 there there EX cord-302953-gr2kk9w4 201 9 were be VBD cord-302953-gr2kk9w4 201 10 more more RBR cord-302953-gr2kk9w4 201 11 total total JJ cord-302953-gr2kk9w4 201 12 mononuclear mononuclear JJ cord-302953-gr2kk9w4 201 13 cells cell NNS cord-302953-gr2kk9w4 201 14 in in IN cord-302953-gr2kk9w4 201 15 WT WT NNP cord-302953-gr2kk9w4 201 16 mice mouse NNS cord-302953-gr2kk9w4 201 17 than than IN cord-302953-gr2kk9w4 201 18 Ifng Ifng NNP cord-302953-gr2kk9w4 201 19 −/− −/− NNP cord-302953-gr2kk9w4 201 20 mice mouse NNS cord-302953-gr2kk9w4 201 21 ( ( -LRB- cord-302953-gr2kk9w4 201 22 Figure figure NN cord-302953-gr2kk9w4 201 23 7A 7a NN cord-302953-gr2kk9w4 201 24 ) ) -RRB- cord-302953-gr2kk9w4 201 25 , , , cord-302953-gr2kk9w4 201 26 but but CC cord-302953-gr2kk9w4 201 27 similar similar JJ cord-302953-gr2kk9w4 201 28 numbers number NNS cord-302953-gr2kk9w4 201 29 at at IN cord-302953-gr2kk9w4 201 30 7 7 CD cord-302953-gr2kk9w4 201 31 and and CC cord-302953-gr2kk9w4 201 32 10 10 CD cord-302953-gr2kk9w4 201 33 DPI DPI NNP cord-302953-gr2kk9w4 201 34 . . . cord-302953-gr2kk9w4 202 1 Neither neither CC cord-302953-gr2kk9w4 202 2 the the DT cord-302953-gr2kk9w4 202 3 percentage percentage NN cord-302953-gr2kk9w4 202 4 nor nor CC cord-302953-gr2kk9w4 202 5 absolute absolute JJ cord-302953-gr2kk9w4 202 6 number number NN cord-302953-gr2kk9w4 202 7 of of IN cord-302953-gr2kk9w4 202 8 CD4 CD4 NNP cord-302953-gr2kk9w4 202 9 + + CC cord-302953-gr2kk9w4 202 10 T t NN cord-302953-gr2kk9w4 202 11 cells cell NNS cord-302953-gr2kk9w4 202 12 ( ( -LRB- cord-302953-gr2kk9w4 202 13 Figure Figure NNP cord-302953-gr2kk9w4 202 14 7C 7C NNP cord-302953-gr2kk9w4 202 15 ) ) -RRB- cord-302953-gr2kk9w4 202 16 or or CC cord-302953-gr2kk9w4 202 17 CD8 CD8 NNP cord-302953-gr2kk9w4 202 18 + + CC cord-302953-gr2kk9w4 202 19 T T NNP cord-302953-gr2kk9w4 202 20 cells cell NNS cord-302953-gr2kk9w4 202 21 ( ( -LRB- cord-302953-gr2kk9w4 202 22 Figure Figure NNP cord-302953-gr2kk9w4 202 23 7D 7D NNP cord-302953-gr2kk9w4 202 24 ) ) -RRB- cord-302953-gr2kk9w4 202 25 in in IN cord-302953-gr2kk9w4 202 26 CLNs cln NNS cord-302953-gr2kk9w4 202 27 were be VBD cord-302953-gr2kk9w4 202 28 affected affect VBN cord-302953-gr2kk9w4 202 29 by by IN cord-302953-gr2kk9w4 202 30 impaired impaired JJ cord-302953-gr2kk9w4 202 31 IFN IFN NNP cord-302953-gr2kk9w4 202 32 - - HYPH cord-302953-gr2kk9w4 202 33 γ γ NNP cord-302953-gr2kk9w4 202 34 signaling signaling NN cord-302953-gr2kk9w4 202 35 , , , cord-302953-gr2kk9w4 202 36 with with IN cord-302953-gr2kk9w4 202 37 a a DT cord-302953-gr2kk9w4 202 38 general general JJ cord-302953-gr2kk9w4 202 39 overall overall JJ cord-302953-gr2kk9w4 202 40 decrease decrease NN cord-302953-gr2kk9w4 202 41 from from IN cord-302953-gr2kk9w4 202 42 5 5 CD cord-302953-gr2kk9w4 202 43 DPI DPI NNP cord-302953-gr2kk9w4 202 44 to to IN cord-302953-gr2kk9w4 202 45 10 10 CD cord-302953-gr2kk9w4 202 46 DPI DPI NNP cord-302953-gr2kk9w4 202 47 . . . cord-302953-gr2kk9w4 203 1 In in IN cord-302953-gr2kk9w4 203 2 contrast contrast NN cord-302953-gr2kk9w4 203 3 , , , cord-302953-gr2kk9w4 203 4 WT WT NNP cord-302953-gr2kk9w4 203 5 mice mouse NNS cord-302953-gr2kk9w4 203 6 had have VBD cord-302953-gr2kk9w4 203 7 more more JJR cord-302953-gr2kk9w4 203 8 total total JJ cord-302953-gr2kk9w4 203 9 mononuclear mononuclear JJ cord-302953-gr2kk9w4 203 10 cells cell NNS cord-302953-gr2kk9w4 203 11 in in IN cord-302953-gr2kk9w4 203 12 the the DT cord-302953-gr2kk9w4 203 13 brain brain NN cord-302953-gr2kk9w4 203 14 at at IN cord-302953-gr2kk9w4 203 15 7 7 CD cord-302953-gr2kk9w4 203 16 DPI dpi NN cord-302953-gr2kk9w4 203 17 than than IN cord-302953-gr2kk9w4 203 18 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 203 19 −/− −/− NNP cord-302953-gr2kk9w4 203 20 and and CC cord-302953-gr2kk9w4 203 21 Ifng Ifng NNP cord-302953-gr2kk9w4 203 22 −/− −/− NNP cord-302953-gr2kk9w4 203 23 mice mouse NNS cord-302953-gr2kk9w4 203 24 ( ( -LRB- cord-302953-gr2kk9w4 203 25 Figure figure NN cord-302953-gr2kk9w4 203 26 7B 7b NN cord-302953-gr2kk9w4 203 27 ) ) -RRB- cord-302953-gr2kk9w4 203 28 . . . cord-302953-gr2kk9w4 204 1 Numbers number NNS cord-302953-gr2kk9w4 204 2 of of IN cord-302953-gr2kk9w4 204 3 infiltrating infiltrate VBG cord-302953-gr2kk9w4 204 4 CD8 CD8 NNP cord-302953-gr2kk9w4 204 5 + + CC cord-302953-gr2kk9w4 204 6 T t NN cord-302953-gr2kk9w4 204 7 cells cell NNS cord-302953-gr2kk9w4 204 8 peaked peak VBD cord-302953-gr2kk9w4 204 9 at at IN cord-302953-gr2kk9w4 204 10 7 7 CD cord-302953-gr2kk9w4 204 11 DPI DPI NNP cord-302953-gr2kk9w4 204 12 , , , cord-302953-gr2kk9w4 204 13 while while IN cord-302953-gr2kk9w4 204 14 infiltration infiltration NN cord-302953-gr2kk9w4 204 15 of of IN cord-302953-gr2kk9w4 204 16 CD4 CD4 NNP cord-302953-gr2kk9w4 204 17 + + CC cord-302953-gr2kk9w4 204 18 T t NN cord-302953-gr2kk9w4 204 19 cells cell NNS cord-302953-gr2kk9w4 204 20 occurred occur VBD cord-302953-gr2kk9w4 204 21 later later RB cord-302953-gr2kk9w4 204 22 with with IN cord-302953-gr2kk9w4 204 23 peaks peak NNS cord-302953-gr2kk9w4 204 24 at at IN cord-302953-gr2kk9w4 204 25 10 10 CD cord-302953-gr2kk9w4 204 26 DPI DPI NNP cord-302953-gr2kk9w4 204 27 . . . cord-302953-gr2kk9w4 205 1 WT WT NNP cord-302953-gr2kk9w4 205 2 mice mouse NNS cord-302953-gr2kk9w4 205 3 had have VBD cord-302953-gr2kk9w4 205 4 more more JJR cord-302953-gr2kk9w4 205 5 CD4 CD4 NNP cord-302953-gr2kk9w4 205 6 + + CC cord-302953-gr2kk9w4 205 7 T t NN cord-302953-gr2kk9w4 205 8 cells cell NNS cord-302953-gr2kk9w4 205 9 than than IN cord-302953-gr2kk9w4 205 10 Ifng Ifng NNP cord-302953-gr2kk9w4 205 11 −/− −/− NNP cord-302953-gr2kk9w4 205 12 mice mouse NNS cord-302953-gr2kk9w4 205 13 at at IN cord-302953-gr2kk9w4 205 14 10 10 CD cord-302953-gr2kk9w4 205 15 DPI DPI NNP cord-302953-gr2kk9w4 205 16 ( ( -LRB- cord-302953-gr2kk9w4 205 17 Figure Figure NNP cord-302953-gr2kk9w4 205 18 7E 7E NNP cord-302953-gr2kk9w4 205 19 ) ) -RRB- cord-302953-gr2kk9w4 205 20 , , , cord-302953-gr2kk9w4 205 21 while while IN cord-302953-gr2kk9w4 205 22 both both CC cord-302953-gr2kk9w4 205 23 the the DT cord-302953-gr2kk9w4 205 24 percentage percentage NN cord-302953-gr2kk9w4 205 25 of of IN cord-302953-gr2kk9w4 205 26 cells cell NNS cord-302953-gr2kk9w4 205 27 and and CC cord-302953-gr2kk9w4 205 28 absolute absolute JJ cord-302953-gr2kk9w4 205 29 numbers number NNS cord-302953-gr2kk9w4 205 30 of of IN cord-302953-gr2kk9w4 205 31 CD8 CD8 NNP cord-302953-gr2kk9w4 205 32 + + CC cord-302953-gr2kk9w4 205 33 T T NNP cord-302953-gr2kk9w4 205 34 cells cell NNS cord-302953-gr2kk9w4 205 35 were be VBD cord-302953-gr2kk9w4 205 36 lower low JJR cord-302953-gr2kk9w4 205 37 in in IN cord-302953-gr2kk9w4 205 38 brains brain NNS cord-302953-gr2kk9w4 205 39 of of IN cord-302953-gr2kk9w4 205 40 WT WT NNP cord-302953-gr2kk9w4 205 41 mice mouse NNS cord-302953-gr2kk9w4 205 42 than than IN cord-302953-gr2kk9w4 205 43 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 205 44 −/− −/− NNP cord-302953-gr2kk9w4 205 45 and and CC cord-302953-gr2kk9w4 205 46 Ifng Ifng NNP cord-302953-gr2kk9w4 205 47 −/− −/− NNP cord-302953-gr2kk9w4 205 48 mice mouse NNS cord-302953-gr2kk9w4 205 49 at at IN cord-302953-gr2kk9w4 205 50 7 7 CD cord-302953-gr2kk9w4 205 51 DPI DPI NNP cord-302953-gr2kk9w4 205 52 ( ( -LRB- cord-302953-gr2kk9w4 205 53 Figure figure NN cord-302953-gr2kk9w4 205 54 7F 7f CD cord-302953-gr2kk9w4 205 55 ) ) -RRB- cord-302953-gr2kk9w4 205 56 , , , cord-302953-gr2kk9w4 205 57 despite despite IN cord-302953-gr2kk9w4 205 58 the the DT cord-302953-gr2kk9w4 205 59 fact fact NN cord-302953-gr2kk9w4 205 60 that that IN cord-302953-gr2kk9w4 205 61 WT WT NNP cord-302953-gr2kk9w4 205 62 mice mouse NNS cord-302953-gr2kk9w4 205 63 had have VBD cord-302953-gr2kk9w4 205 64 more more JJR cord-302953-gr2kk9w4 205 65 overall overall JJ cord-302953-gr2kk9w4 205 66 brain brain NN cord-302953-gr2kk9w4 205 67 mononuclear mononuclear NN cord-302953-gr2kk9w4 205 68 cells cell NNS cord-302953-gr2kk9w4 205 69 at at IN cord-302953-gr2kk9w4 205 70 this this DT cord-302953-gr2kk9w4 205 71 time time NN cord-302953-gr2kk9w4 205 72 ( ( -LRB- cord-302953-gr2kk9w4 205 73 Figure figure NN cord-302953-gr2kk9w4 205 74 7B 7b NN cord-302953-gr2kk9w4 205 75 ) ) -RRB- cord-302953-gr2kk9w4 205 76 . . . cord-302953-gr2kk9w4 206 1 Therefore therefore RB cord-302953-gr2kk9w4 206 2 , , , cord-302953-gr2kk9w4 206 3 while while IN cord-302953-gr2kk9w4 206 4 the the DT cord-302953-gr2kk9w4 206 5 absence absence NN cord-302953-gr2kk9w4 206 6 of of IN cord-302953-gr2kk9w4 206 7 IFN IFN NNP cord-302953-gr2kk9w4 206 8 - - HYPH cord-302953-gr2kk9w4 206 9 γ γ NNP cord-302953-gr2kk9w4 206 10 signaling signaling NN cord-302953-gr2kk9w4 206 11 did do VBD cord-302953-gr2kk9w4 206 12 not not RB cord-302953-gr2kk9w4 206 13 affect affect VB cord-302953-gr2kk9w4 206 14 the the DT cord-302953-gr2kk9w4 206 15 proliferation proliferation NN cord-302953-gr2kk9w4 206 16 of of IN cord-302953-gr2kk9w4 206 17 T t NN cord-302953-gr2kk9w4 206 18 cells cell NNS cord-302953-gr2kk9w4 206 19 in in IN cord-302953-gr2kk9w4 206 20 CLNs cln NNS cord-302953-gr2kk9w4 206 21 in in IN cord-302953-gr2kk9w4 206 22 response response NN cord-302953-gr2kk9w4 206 23 to to IN cord-302953-gr2kk9w4 206 24 SINV SINV NNP cord-302953-gr2kk9w4 206 25 infection infection NN cord-302953-gr2kk9w4 206 26 , , , cord-302953-gr2kk9w4 206 27 it -PRON- PRP cord-302953-gr2kk9w4 206 28 did do VBD cord-302953-gr2kk9w4 206 29 affect affect VB cord-302953-gr2kk9w4 206 30 recruitment recruitment NN cord-302953-gr2kk9w4 206 31 of of IN cord-302953-gr2kk9w4 206 32 these these DT cord-302953-gr2kk9w4 206 33 cells cell NNS cord-302953-gr2kk9w4 206 34 to to IN cord-302953-gr2kk9w4 206 35 the the DT cord-302953-gr2kk9w4 206 36 site site NN cord-302953-gr2kk9w4 206 37 of of IN cord-302953-gr2kk9w4 206 38 infection infection NN cord-302953-gr2kk9w4 206 39 in in IN cord-302953-gr2kk9w4 206 40 the the DT cord-302953-gr2kk9w4 206 41 brain brain NN cord-302953-gr2kk9w4 206 42 . . . cord-302953-gr2kk9w4 207 1 Because because IN cord-302953-gr2kk9w4 207 2 WT WT NNP cord-302953-gr2kk9w4 207 3 mice mouse NNS cord-302953-gr2kk9w4 207 4 have have VBP cord-302953-gr2kk9w4 207 5 more more JJR cord-302953-gr2kk9w4 207 6 inflammation inflammation NN cord-302953-gr2kk9w4 207 7 ( ( -LRB- cord-302953-gr2kk9w4 207 8 Figure figure NN cord-302953-gr2kk9w4 207 9 6 6 CD cord-302953-gr2kk9w4 207 10 ) ) -RRB- cord-302953-gr2kk9w4 207 11 and and CC cord-302953-gr2kk9w4 207 12 more more JJR cord-302953-gr2kk9w4 207 13 mononuclear mononuclear JJ cord-302953-gr2kk9w4 207 14 cells cell NNS cord-302953-gr2kk9w4 207 15 ( ( -LRB- cord-302953-gr2kk9w4 207 16 Figure figure NN cord-302953-gr2kk9w4 207 17 7B 7b NN cord-302953-gr2kk9w4 207 18 ) ) -RRB- cord-302953-gr2kk9w4 207 19 , , , cord-302953-gr2kk9w4 207 20 but but CC cord-302953-gr2kk9w4 207 21 fewer few JJR cord-302953-gr2kk9w4 207 22 CD8 CD8 NNS cord-302953-gr2kk9w4 207 23 + + CC cord-302953-gr2kk9w4 207 24 T t NN cord-302953-gr2kk9w4 207 25 cells cell NNS cord-302953-gr2kk9w4 207 26 ( ( -LRB- cord-302953-gr2kk9w4 207 27 Figure figure NN cord-302953-gr2kk9w4 207 28 7F 7f CD cord-302953-gr2kk9w4 207 29 ) ) -RRB- cord-302953-gr2kk9w4 207 30 in in IN cord-302953-gr2kk9w4 207 31 brain brain NN cord-302953-gr2kk9w4 207 32 compared compare VBN cord-302953-gr2kk9w4 207 33 to to IN cord-302953-gr2kk9w4 207 34 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 207 35 −/− −/− NNP cord-302953-gr2kk9w4 207 36 and and CC cord-302953-gr2kk9w4 207 37 Ifng Ifng NNP cord-302953-gr2kk9w4 207 38 −/− −/− NNP cord-302953-gr2kk9w4 207 39 mice mouse NNS cord-302953-gr2kk9w4 207 40 at at IN cord-302953-gr2kk9w4 207 41 7 7 CD cord-302953-gr2kk9w4 207 42 DPI DPI NNP cord-302953-gr2kk9w4 207 43 , , , cord-302953-gr2kk9w4 207 44 non non JJ cord-302953-gr2kk9w4 207 45 - - JJ cord-302953-gr2kk9w4 207 46 T t JJ cord-302953-gr2kk9w4 207 47 cell cell NN cord-302953-gr2kk9w4 207 48 immune immune JJ cord-302953-gr2kk9w4 207 49 cell cell NN cord-302953-gr2kk9w4 207 50 populations population NNS cord-302953-gr2kk9w4 207 51 were be VBD cord-302953-gr2kk9w4 207 52 assessed assess VBN cord-302953-gr2kk9w4 207 53 . . . cord-302953-gr2kk9w4 208 1 Macrophages macrophage NNS cord-302953-gr2kk9w4 208 2 ( ( -LRB- cord-302953-gr2kk9w4 208 3 Figure figure NN cord-302953-gr2kk9w4 208 4 7 7 CD cord-302953-gr2kk9w4 208 5 G g NN cord-302953-gr2kk9w4 208 6 ) ) -RRB- cord-302953-gr2kk9w4 208 7 and and CC cord-302953-gr2kk9w4 208 8 NK NK NNP cord-302953-gr2kk9w4 208 9 cells cell NNS cord-302953-gr2kk9w4 208 10 ( ( -LRB- cord-302953-gr2kk9w4 208 11 Figure figure NN cord-302953-gr2kk9w4 208 12 7I 7i NN cord-302953-gr2kk9w4 208 13 ) ) -RRB- cord-302953-gr2kk9w4 208 14 , , , cord-302953-gr2kk9w4 208 15 both both CC cord-302953-gr2kk9w4 208 16 as as IN cord-302953-gr2kk9w4 208 17 a a DT cord-302953-gr2kk9w4 208 18 percentage percentage NN cord-302953-gr2kk9w4 208 19 of of IN cord-302953-gr2kk9w4 208 20 the the DT cord-302953-gr2kk9w4 208 21 total total JJ cord-302953-gr2kk9w4 208 22 live live JJ cord-302953-gr2kk9w4 208 23 mononuclear mononuclear JJ cord-302953-gr2kk9w4 208 24 cell cell NN cord-302953-gr2kk9w4 208 25 population population NN cord-302953-gr2kk9w4 208 26 and and CC cord-302953-gr2kk9w4 208 27 absolute absolute JJ cord-302953-gr2kk9w4 208 28 numbers number NNS cord-302953-gr2kk9w4 208 29 , , , cord-302953-gr2kk9w4 208 30 were be VBD cord-302953-gr2kk9w4 208 31 higher high JJR cord-302953-gr2kk9w4 208 32 in in IN cord-302953-gr2kk9w4 208 33 WT WT NNP cord-302953-gr2kk9w4 208 34 mouse mouse NN cord-302953-gr2kk9w4 208 35 brains brain NNS cord-302953-gr2kk9w4 208 36 compared compare VBN cord-302953-gr2kk9w4 208 37 to to IN cord-302953-gr2kk9w4 208 38 mice mouse NNS cord-302953-gr2kk9w4 208 39 with with IN cord-302953-gr2kk9w4 208 40 impaired impaired JJ cord-302953-gr2kk9w4 208 41 IFN IFN NNP cord-302953-gr2kk9w4 208 42 - - HYPH cord-302953-gr2kk9w4 208 43 γ γ NNP cord-302953-gr2kk9w4 208 44 signaling signaling NN cord-302953-gr2kk9w4 208 45 , , , cord-302953-gr2kk9w4 208 46 while while IN cord-302953-gr2kk9w4 208 47 neutrophils neutrophil NNS cord-302953-gr2kk9w4 208 48 tended tend VBD cord-302953-gr2kk9w4 208 49 to to TO cord-302953-gr2kk9w4 208 50 be be VB cord-302953-gr2kk9w4 208 51 higher high JJR cord-302953-gr2kk9w4 208 52 in in IN cord-302953-gr2kk9w4 208 53 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 208 54 −/− −/− NNP cord-302953-gr2kk9w4 208 55 mouse mouse NN cord-302953-gr2kk9w4 208 56 brains brain NNS cord-302953-gr2kk9w4 208 57 ( ( -LRB- cord-302953-gr2kk9w4 208 58 Figure figure NN cord-302953-gr2kk9w4 208 59 7H 7h CD cord-302953-gr2kk9w4 208 60 ) ) -RRB- cord-302953-gr2kk9w4 208 61 . . . cord-302953-gr2kk9w4 209 1 Microglial microglial JJ cord-302953-gr2kk9w4 209 2 cells cell NNS cord-302953-gr2kk9w4 209 3 as as IN cord-302953-gr2kk9w4 209 4 a a DT cord-302953-gr2kk9w4 209 5 percentage percentage NN cord-302953-gr2kk9w4 209 6 of of IN cord-302953-gr2kk9w4 209 7 the the DT cord-302953-gr2kk9w4 209 8 total total JJ cord-302953-gr2kk9w4 209 9 brain brain NN cord-302953-gr2kk9w4 209 10 mononuclear mononuclear JJ cord-302953-gr2kk9w4 209 11 cell cell NN cord-302953-gr2kk9w4 209 12 population population NN cord-302953-gr2kk9w4 209 13 were be VBD cord-302953-gr2kk9w4 209 14 higher high JJR cord-302953-gr2kk9w4 209 15 in in IN cord-302953-gr2kk9w4 209 16 Ifng Ifng NNP cord-302953-gr2kk9w4 209 17 −/− −/− NNP cord-302953-gr2kk9w4 209 18 compared compare VBN cord-302953-gr2kk9w4 209 19 to to IN cord-302953-gr2kk9w4 209 20 WT WT NNP cord-302953-gr2kk9w4 209 21 and and CC cord-302953-gr2kk9w4 209 22 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 209 23 −/− −/− NNP cord-302953-gr2kk9w4 209 24 mice mouse NNS cord-302953-gr2kk9w4 209 25 ( ( -LRB- cord-302953-gr2kk9w4 209 26 Figure figure NN cord-302953-gr2kk9w4 209 27 7J 7j CD cord-302953-gr2kk9w4 209 28 ) ) -RRB- cord-302953-gr2kk9w4 209 29 , , , cord-302953-gr2kk9w4 209 30 but but CC cord-302953-gr2kk9w4 209 31 absolute absolute JJ cord-302953-gr2kk9w4 209 32 numbers number NNS cord-302953-gr2kk9w4 209 33 of of IN cord-302953-gr2kk9w4 209 34 microglia microglia NNS cord-302953-gr2kk9w4 209 35 were be VBD cord-302953-gr2kk9w4 209 36 comparable comparable JJ cord-302953-gr2kk9w4 209 37 . . . cord-302953-gr2kk9w4 210 1 Therefore therefore RB cord-302953-gr2kk9w4 210 2 , , , cord-302953-gr2kk9w4 210 3 the the DT cord-302953-gr2kk9w4 210 4 larger large JJR cord-302953-gr2kk9w4 210 5 number number NN cord-302953-gr2kk9w4 210 6 of of IN cord-302953-gr2kk9w4 210 7 mononuclear mononuclear JJ cord-302953-gr2kk9w4 210 8 cells cell NNS cord-302953-gr2kk9w4 210 9 in in IN cord-302953-gr2kk9w4 210 10 the the DT cord-302953-gr2kk9w4 210 11 brains brain NNS cord-302953-gr2kk9w4 210 12 of of IN cord-302953-gr2kk9w4 210 13 WT WT NNP cord-302953-gr2kk9w4 210 14 mice mouse NNS cord-302953-gr2kk9w4 210 15 at at IN cord-302953-gr2kk9w4 210 16 7 7 CD cord-302953-gr2kk9w4 210 17 DPI DPI NNP cord-302953-gr2kk9w4 210 18 compared compare VBN cord-302953-gr2kk9w4 210 19 to to IN cord-302953-gr2kk9w4 210 20 mice mouse NNS cord-302953-gr2kk9w4 210 21 with with IN cord-302953-gr2kk9w4 210 22 impaired impaired JJ cord-302953-gr2kk9w4 210 23 IFN IFN NNP cord-302953-gr2kk9w4 210 24 - - HYPH cord-302953-gr2kk9w4 210 25 γ γ NNP cord-302953-gr2kk9w4 210 26 signaling signaling NN cord-302953-gr2kk9w4 210 27 was be VBD cord-302953-gr2kk9w4 210 28 due due JJ cord-302953-gr2kk9w4 210 29 to to IN cord-302953-gr2kk9w4 210 30 infiltration infiltration NN cord-302953-gr2kk9w4 210 31 of of IN cord-302953-gr2kk9w4 210 32 more more JJR cord-302953-gr2kk9w4 210 33 macrophages macrophage NNS cord-302953-gr2kk9w4 210 34 and and CC cord-302953-gr2kk9w4 210 35 NK NK NNP cord-302953-gr2kk9w4 210 36 cells cell NNS cord-302953-gr2kk9w4 210 37 . . . cord-302953-gr2kk9w4 211 1 Because because IN cord-302953-gr2kk9w4 211 2 impaired impaired JJ cord-302953-gr2kk9w4 211 3 IFN IFN NNP cord-302953-gr2kk9w4 211 4 - - HYPH cord-302953-gr2kk9w4 211 5 γ γ NN cord-302953-gr2kk9w4 211 6 signaling signaling NN cord-302953-gr2kk9w4 211 7 altered alter VBD cord-302953-gr2kk9w4 211 8 the the DT cord-302953-gr2kk9w4 211 9 numbers number NNS cord-302953-gr2kk9w4 211 10 of of IN cord-302953-gr2kk9w4 211 11 CD4 CD4 NNP cord-302953-gr2kk9w4 211 12 + + CC cord-302953-gr2kk9w4 211 13 and and CC cord-302953-gr2kk9w4 211 14 CD8 CD8 NNP cord-302953-gr2kk9w4 211 15 + + CC cord-302953-gr2kk9w4 211 16 T t NN cord-302953-gr2kk9w4 211 17 cells cell NNS cord-302953-gr2kk9w4 211 18 infiltrating infiltrate VBG cord-302953-gr2kk9w4 211 19 the the DT cord-302953-gr2kk9w4 211 20 brain brain NN cord-302953-gr2kk9w4 211 21 during during IN cord-302953-gr2kk9w4 211 22 SINV SINV NNP cord-302953-gr2kk9w4 211 23 infection infection NN cord-302953-gr2kk9w4 211 24 , , , cord-302953-gr2kk9w4 211 25 we -PRON- PRP cord-302953-gr2kk9w4 211 26 sought seek VBD cord-302953-gr2kk9w4 211 27 to to TO cord-302953-gr2kk9w4 211 28 determine determine VB cord-302953-gr2kk9w4 211 29 the the DT cord-302953-gr2kk9w4 211 30 effector effector JJ cord-302953-gr2kk9w4 211 31 function function NN cord-302953-gr2kk9w4 211 32 of of IN cord-302953-gr2kk9w4 211 33 these these DT cord-302953-gr2kk9w4 211 34 cells cell NNS cord-302953-gr2kk9w4 211 35 . . . cord-302953-gr2kk9w4 212 1 Brain Brain NNP cord-302953-gr2kk9w4 212 2 CD4 CD4 NNP cord-302953-gr2kk9w4 212 3 + + CC cord-302953-gr2kk9w4 212 4 T t NN cord-302953-gr2kk9w4 212 5 cells cell NNS cord-302953-gr2kk9w4 212 6 at at IN cord-302953-gr2kk9w4 212 7 7 7 CD cord-302953-gr2kk9w4 212 8 DPI DPI NNP cord-302953-gr2kk9w4 212 9 were be VBD cord-302953-gr2kk9w4 212 10 characterized characterize VBN cord-302953-gr2kk9w4 212 11 further further RB cord-302953-gr2kk9w4 212 12 by by IN cord-302953-gr2kk9w4 212 13 measuring measure VBG cord-302953-gr2kk9w4 212 14 production production NN cord-302953-gr2kk9w4 212 15 of of IN cord-302953-gr2kk9w4 212 16 signature signature NN cord-302953-gr2kk9w4 212 17 cytokines cytokine NNS cord-302953-gr2kk9w4 212 18 and and CC cord-302953-gr2kk9w4 212 19 transcription transcription NN cord-302953-gr2kk9w4 212 20 factors factor NNS cord-302953-gr2kk9w4 212 21 ( ( -LRB- cord-302953-gr2kk9w4 212 22 Figure figure NN cord-302953-gr2kk9w4 212 23 8A 8a NN cord-302953-gr2kk9w4 212 24 -D -D -RRB- cord-302953-gr2kk9w4 212 25 ) ) -RRB- cord-302953-gr2kk9w4 212 26 and and CC cord-302953-gr2kk9w4 212 27 expression expression NN cord-302953-gr2kk9w4 212 28 of of IN cord-302953-gr2kk9w4 212 29 cytokine cytokine NN cord-302953-gr2kk9w4 212 30 ( ( -LRB- cord-302953-gr2kk9w4 212 31 Figure figure NN cord-302953-gr2kk9w4 212 32 8E 8e CD cord-302953-gr2kk9w4 212 33 -H -H NFP cord-302953-gr2kk9w4 212 34 ) ) -RRB- cord-302953-gr2kk9w4 212 35 and and CC cord-302953-gr2kk9w4 212 36 transcription transcription NN cord-302953-gr2kk9w4 212 37 factor factor NN cord-302953-gr2kk9w4 212 38 ( ( -LRB- cord-302953-gr2kk9w4 212 39 Figure figure NN cord-302953-gr2kk9w4 212 40 8I 8i CD cord-302953-gr2kk9w4 212 41 -L -l ADD cord-302953-gr2kk9w4 212 42 ) ) -RRB- cord-302953-gr2kk9w4 213 1 mRNAs mrnas LS cord-302953-gr2kk9w4 213 2 associated associate VBN cord-302953-gr2kk9w4 213 3 with with IN cord-302953-gr2kk9w4 213 4 different different JJ cord-302953-gr2kk9w4 213 5 T t NN cord-302953-gr2kk9w4 213 6 helper helper NN cord-302953-gr2kk9w4 213 7 ( ( -LRB- cord-302953-gr2kk9w4 213 8 Th Th NNP cord-302953-gr2kk9w4 213 9 ) ) -RRB- cord-302953-gr2kk9w4 213 10 subsets subset NNS cord-302953-gr2kk9w4 213 11 . . . cord-302953-gr2kk9w4 214 1 As as IN cord-302953-gr2kk9w4 214 2 expected expect VBN cord-302953-gr2kk9w4 214 3 , , , cord-302953-gr2kk9w4 214 4 IFN IFN NNP cord-302953-gr2kk9w4 214 5 - - HYPH cord-302953-gr2kk9w4 214 6 γ γ NNP cord-302953-gr2kk9w4 214 7 ( ( -LRB- cord-302953-gr2kk9w4 214 8 Th1 th1 NN cord-302953-gr2kk9w4 214 9 cells cell NNS cord-302953-gr2kk9w4 214 10 ) ) -RRB- cord-302953-gr2kk9w4 214 11 was be VBD cord-302953-gr2kk9w4 214 12 not not RB cord-302953-gr2kk9w4 214 13 produced produce VBN cord-302953-gr2kk9w4 214 14 by by IN cord-302953-gr2kk9w4 214 15 CD4 CD4 NNP cord-302953-gr2kk9w4 214 16 + + CC cord-302953-gr2kk9w4 214 17 T T NNP cord-302953-gr2kk9w4 214 18 cells cell NNS cord-302953-gr2kk9w4 214 19 in in IN cord-302953-gr2kk9w4 215 1 Ifng Ifng NNP cord-302953-gr2kk9w4 215 2 −/− −/− NNP cord-302953-gr2kk9w4 215 3 mice mouse NNS cord-302953-gr2kk9w4 215 4 , , , cord-302953-gr2kk9w4 215 5 and and CC cord-302953-gr2kk9w4 215 6 the the DT cord-302953-gr2kk9w4 215 7 percentage percentage NN cord-302953-gr2kk9w4 215 8 of of IN cord-302953-gr2kk9w4 215 9 CD4 CD4 NNP cord-302953-gr2kk9w4 215 10 + + CC cord-302953-gr2kk9w4 215 11 T t NN cord-302953-gr2kk9w4 215 12 cells cell NNS cord-302953-gr2kk9w4 215 13 producing produce VBG cord-302953-gr2kk9w4 215 14 IFN IFN NNP cord-302953-gr2kk9w4 215 15 - - HYPH cord-302953-gr2kk9w4 215 16 γ γ NNP cord-302953-gr2kk9w4 215 17 did do VBD cord-302953-gr2kk9w4 215 18 not not RB cord-302953-gr2kk9w4 215 19 differ differ VB cord-302953-gr2kk9w4 215 20 between between IN cord-302953-gr2kk9w4 215 21 WT WT NNP cord-302953-gr2kk9w4 215 22 and and CC cord-302953-gr2kk9w4 215 23 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 215 24 −/− −/− NNP cord-302953-gr2kk9w4 215 25 mice mouse NNS cord-302953-gr2kk9w4 215 26 ( ( -LRB- cord-302953-gr2kk9w4 215 27 Figure figure NN cord-302953-gr2kk9w4 215 28 8A 8a NN cord-302953-gr2kk9w4 215 29 ) ) -RRB- cord-302953-gr2kk9w4 215 30 . . . cord-302953-gr2kk9w4 216 1 The the DT cord-302953-gr2kk9w4 216 2 percentage percentage NN cord-302953-gr2kk9w4 216 3 of of IN cord-302953-gr2kk9w4 216 4 CD4 CD4 NNP cord-302953-gr2kk9w4 216 5 + + CC cord-302953-gr2kk9w4 216 6 T t NN cord-302953-gr2kk9w4 216 7 cells cell NNS cord-302953-gr2kk9w4 216 8 producing produce VBG cord-302953-gr2kk9w4 216 9 IL-4 IL-4 NNP cord-302953-gr2kk9w4 216 10 ( ( -LRB- cord-302953-gr2kk9w4 216 11 Th2 th2 CD cord-302953-gr2kk9w4 216 12 cells cell NNS cord-302953-gr2kk9w4 216 13 ) ) -RRB- cord-302953-gr2kk9w4 216 14 was be VBD cord-302953-gr2kk9w4 216 15 lower low JJR cord-302953-gr2kk9w4 216 16 in in IN cord-302953-gr2kk9w4 216 17 Ifng Ifng NNP cord-302953-gr2kk9w4 216 18 −/− −/− NNP cord-302953-gr2kk9w4 216 19 mice mouse NNS cord-302953-gr2kk9w4 216 20 than than IN cord-302953-gr2kk9w4 216 21 WT WT NNP cord-302953-gr2kk9w4 216 22 or or CC cord-302953-gr2kk9w4 216 23 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 216 24 −/− −/− NNP cord-302953-gr2kk9w4 216 25 mice mouse NNS cord-302953-gr2kk9w4 217 1 ( ( -LRB- cord-302953-gr2kk9w4 217 2 Figure figure NN cord-302953-gr2kk9w4 217 3 8B 8b NN cord-302953-gr2kk9w4 217 4 ) ) -RRB- cord-302953-gr2kk9w4 217 5 . . . cord-302953-gr2kk9w4 218 1 Although although IN cord-302953-gr2kk9w4 218 2 not not RB cord-302953-gr2kk9w4 218 3 significant significant JJ cord-302953-gr2kk9w4 218 4 , , , cord-302953-gr2kk9w4 218 5 more more JJR cord-302953-gr2kk9w4 218 6 CD4 CD4 NNP cord-302953-gr2kk9w4 218 7 + + CC cord-302953-gr2kk9w4 218 8 T t NN cord-302953-gr2kk9w4 218 9 cells cell NNS cord-302953-gr2kk9w4 218 10 in in IN cord-302953-gr2kk9w4 218 11 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 219 1 −/− −/− NNP cord-302953-gr2kk9w4 219 2 mice mouse NNS cord-302953-gr2kk9w4 219 3 produced produce VBD cord-302953-gr2kk9w4 219 4 IL-17a IL-17a NNP cord-302953-gr2kk9w4 219 5 ( ( -LRB- cord-302953-gr2kk9w4 219 6 Th17 Th17 NNP cord-302953-gr2kk9w4 219 7 cells cell NNS cord-302953-gr2kk9w4 219 8 ) ) -RRB- cord-302953-gr2kk9w4 219 9 compared compare VBN cord-302953-gr2kk9w4 219 10 to to IN cord-302953-gr2kk9w4 219 11 WT WT NNP cord-302953-gr2kk9w4 219 12 and and CC cord-302953-gr2kk9w4 219 13 Ifng Ifng NNP cord-302953-gr2kk9w4 219 14 −/− −/− NNP cord-302953-gr2kk9w4 219 15 mice mouse NNS cord-302953-gr2kk9w4 219 16 ( ( -LRB- cord-302953-gr2kk9w4 219 17 Figure figure NN cord-302953-gr2kk9w4 219 18 8C 8c CD cord-302953-gr2kk9w4 219 19 ) ) -RRB- cord-302953-gr2kk9w4 219 20 , , , cord-302953-gr2kk9w4 219 21 and and CC cord-302953-gr2kk9w4 219 22 the the DT cord-302953-gr2kk9w4 219 23 percentage percentage NN cord-302953-gr2kk9w4 219 24 of of IN cord-302953-gr2kk9w4 219 25 CD4 CD4 NNP cord-302953-gr2kk9w4 219 26 + + CC cord-302953-gr2kk9w4 219 27 T t NN cord-302953-gr2kk9w4 219 28 cells cell NNS cord-302953-gr2kk9w4 219 29 expressing express VBG cord-302953-gr2kk9w4 219 30 both both CC cord-302953-gr2kk9w4 219 31 CD25 CD25 NNP cord-302953-gr2kk9w4 219 32 and and CC cord-302953-gr2kk9w4 219 33 Foxp3 foxp3 JJ cord-302953-gr2kk9w4 219 34 ( ( -LRB- cord-302953-gr2kk9w4 219 35 Tregs Tregs NNP cord-302953-gr2kk9w4 219 36 ) ) -RRB- cord-302953-gr2kk9w4 219 37 trended trend VBD cord-302953-gr2kk9w4 219 38 lower lower RBR cord-302953-gr2kk9w4 219 39 in in IN cord-302953-gr2kk9w4 219 40 Ifng Ifng NNP cord-302953-gr2kk9w4 219 41 −/− −/− NNP cord-302953-gr2kk9w4 219 42 mice mouse NNS cord-302953-gr2kk9w4 219 43 ( ( -LRB- cord-302953-gr2kk9w4 219 44 Figure figure NN cord-302953-gr2kk9w4 219 45 8D 8d NN cord-302953-gr2kk9w4 219 46 ) ) -RRB- cord-302953-gr2kk9w4 219 47 . . . cord-302953-gr2kk9w4 220 1 These these DT cord-302953-gr2kk9w4 220 2 results result NNS cord-302953-gr2kk9w4 220 3 show show VBP cord-302953-gr2kk9w4 220 4 that that IN cord-302953-gr2kk9w4 220 5 IFN IFN NNP cord-302953-gr2kk9w4 220 6 - - HYPH cord-302953-gr2kk9w4 220 7 γ γ NNP cord-302953-gr2kk9w4 220 8 signaling signaling NN cord-302953-gr2kk9w4 220 9 affects affect VBZ cord-302953-gr2kk9w4 220 10 CD4 CD4 NNP cord-302953-gr2kk9w4 220 11 + + CC cord-302953-gr2kk9w4 220 12 T T NNP cord-302953-gr2kk9w4 220 13 cell cell NN cord-302953-gr2kk9w4 220 14 function function NN cord-302953-gr2kk9w4 220 15 during during IN cord-302953-gr2kk9w4 220 16 SINV SINV NNP cord-302953-gr2kk9w4 220 17 infection infection NN cord-302953-gr2kk9w4 220 18 , , , cord-302953-gr2kk9w4 220 19 but but CC cord-302953-gr2kk9w4 220 20 impaired impaired JJ cord-302953-gr2kk9w4 220 21 signaling signaling NN cord-302953-gr2kk9w4 220 22 has have VBZ cord-302953-gr2kk9w4 220 23 only only RB cord-302953-gr2kk9w4 220 24 a a DT cord-302953-gr2kk9w4 220 25 modest modest JJ cord-302953-gr2kk9w4 220 26 effect effect NN cord-302953-gr2kk9w4 220 27 on on IN cord-302953-gr2kk9w4 220 28 Th Th NNP cord-302953-gr2kk9w4 220 29 subset subset JJ cord-302953-gr2kk9w4 220 30 profile profile NN cord-302953-gr2kk9w4 220 31 . . . cord-302953-gr2kk9w4 221 1 To to TO cord-302953-gr2kk9w4 221 2 further further RB cord-302953-gr2kk9w4 221 3 evaluate evaluate VB cord-302953-gr2kk9w4 221 4 Th th DT cord-302953-gr2kk9w4 221 5 subsets subset NNS cord-302953-gr2kk9w4 221 6 , , , cord-302953-gr2kk9w4 221 7 mRNAs mrna VBD cord-302953-gr2kk9w4 221 8 for for IN cord-302953-gr2kk9w4 221 9 four four CD cord-302953-gr2kk9w4 221 10 cytokines cytokine NNS cord-302953-gr2kk9w4 221 11 associated associate VBN cord-302953-gr2kk9w4 221 12 with with IN cord-302953-gr2kk9w4 221 13 specific specific JJ cord-302953-gr2kk9w4 221 14 Th Th NNP cord-302953-gr2kk9w4 221 15 profiles profile NNS cord-302953-gr2kk9w4 221 16 were be VBD cord-302953-gr2kk9w4 221 17 examined examine VBN cord-302953-gr2kk9w4 221 18 : : : cord-302953-gr2kk9w4 221 19 Il2 il2 NN cord-302953-gr2kk9w4 221 20 for for IN cord-302953-gr2kk9w4 221 21 Th1 th1 NN cord-302953-gr2kk9w4 221 22 cells cell NNS cord-302953-gr2kk9w4 221 23 ( ( -LRB- cord-302953-gr2kk9w4 221 24 Figure figure NN cord-302953-gr2kk9w4 221 25 8E 8E NNP cord-302953-gr2kk9w4 221 26 ) ) -RRB- cord-302953-gr2kk9w4 221 27 , , , cord-302953-gr2kk9w4 221 28 Il4 Il4 NNP cord-302953-gr2kk9w4 221 29 for for IN cord-302953-gr2kk9w4 221 30 Th2 th2 CD cord-302953-gr2kk9w4 221 31 cells cell NNS cord-302953-gr2kk9w4 221 32 ( ( -LRB- cord-302953-gr2kk9w4 221 33 Figure figure NN cord-302953-gr2kk9w4 221 34 8F 8f NN cord-302953-gr2kk9w4 221 35 ) ) -RRB- cord-302953-gr2kk9w4 221 36 , , , cord-302953-gr2kk9w4 221 37 Il17a il17a NN cord-302953-gr2kk9w4 221 38 for for IN cord-302953-gr2kk9w4 221 39 Th17 Th17 NNP cord-302953-gr2kk9w4 221 40 cells cell NNS cord-302953-gr2kk9w4 222 1 ( ( -LRB- cord-302953-gr2kk9w4 222 2 Figure figure NN cord-302953-gr2kk9w4 222 3 8 8 CD cord-302953-gr2kk9w4 222 4 G G NNP cord-302953-gr2kk9w4 222 5 ) ) -RRB- cord-302953-gr2kk9w4 222 6 , , , cord-302953-gr2kk9w4 222 7 and and CC cord-302953-gr2kk9w4 222 8 Il10 Il10 NNP cord-302953-gr2kk9w4 222 9 for for IN cord-302953-gr2kk9w4 222 10 Tregs Tregs NNP cord-302953-gr2kk9w4 222 11 ( ( -LRB- cord-302953-gr2kk9w4 222 12 Figure figure NN cord-302953-gr2kk9w4 222 13 8H 8h CD cord-302953-gr2kk9w4 222 14 ) ) -RRB- cord-302953-gr2kk9w4 222 15 . . . cord-302953-gr2kk9w4 223 1 At at IN cord-302953-gr2kk9w4 223 2 7 7 CD cord-302953-gr2kk9w4 223 3 DPI DPI NNP cord-302953-gr2kk9w4 223 4 , , , cord-302953-gr2kk9w4 223 5 mRNA mrna NN cord-302953-gr2kk9w4 223 6 expression expression NN cord-302953-gr2kk9w4 223 7 of of IN cord-302953-gr2kk9w4 223 8 Il2 il2 NN cord-302953-gr2kk9w4 223 9 and and CC cord-302953-gr2kk9w4 223 10 Il10 Il10 NNP cord-302953-gr2kk9w4 223 11 was be VBD cord-302953-gr2kk9w4 223 12 lower low JJR cord-302953-gr2kk9w4 223 13 in in IN cord-302953-gr2kk9w4 223 14 Ifng Ifng NNP cord-302953-gr2kk9w4 223 15 −/− −/− NNP cord-302953-gr2kk9w4 223 16 mice mouse NNS cord-302953-gr2kk9w4 223 17 , , , cord-302953-gr2kk9w4 223 18 and and CC cord-302953-gr2kk9w4 223 19 expression expression NN cord-302953-gr2kk9w4 223 20 of of IN cord-302953-gr2kk9w4 223 21 Il17a il17a NN cord-302953-gr2kk9w4 223 22 was be VBD cord-302953-gr2kk9w4 223 23 higher high JJR cord-302953-gr2kk9w4 223 24 in in IN cord-302953-gr2kk9w4 223 25 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 223 26 −/− −/− NNP cord-302953-gr2kk9w4 223 27 mice mouse NNS cord-302953-gr2kk9w4 223 28 . . . cord-302953-gr2kk9w4 224 1 Il4 il4 JJ cord-302953-gr2kk9w4 224 2 expression expression NN cord-302953-gr2kk9w4 224 3 did do VBD cord-302953-gr2kk9w4 224 4 not not RB cord-302953-gr2kk9w4 224 5 significantly significantly RB cord-302953-gr2kk9w4 224 6 differ differ VB cord-302953-gr2kk9w4 224 7 among among IN cord-302953-gr2kk9w4 224 8 strains strain NNS cord-302953-gr2kk9w4 224 9 . . . cord-302953-gr2kk9w4 225 1 Expression expression NN cord-302953-gr2kk9w4 225 2 of of IN cord-302953-gr2kk9w4 225 3 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 225 4 for for IN cord-302953-gr2kk9w4 225 5 transcription transcription NN cord-302953-gr2kk9w4 225 6 factors factor NNS cord-302953-gr2kk9w4 225 7 Tbx21 Tbx21 NNP cord-302953-gr2kk9w4 225 8 for for IN cord-302953-gr2kk9w4 225 9 Th1 th1 NN cord-302953-gr2kk9w4 225 10 cells cell NNS cord-302953-gr2kk9w4 225 11 ( ( -LRB- cord-302953-gr2kk9w4 225 12 Figure figure NN cord-302953-gr2kk9w4 225 13 8I 8i CD cord-302953-gr2kk9w4 225 14 ) ) -RRB- cord-302953-gr2kk9w4 225 15 , , , cord-302953-gr2kk9w4 225 16 Gata3 Gata3 NNP cord-302953-gr2kk9w4 225 17 for for IN cord-302953-gr2kk9w4 225 18 Th2 th2 CD cord-302953-gr2kk9w4 225 19 cells cell NNS cord-302953-gr2kk9w4 225 20 ( ( -LRB- cord-302953-gr2kk9w4 225 21 Figure figure NN cord-302953-gr2kk9w4 225 22 8J 8j NN cord-302953-gr2kk9w4 225 23 ) ) -RRB- cord-302953-gr2kk9w4 225 24 , , . cord-302953-gr2kk9w4 226 1 Rorc Rorc NNP cord-302953-gr2kk9w4 226 2 for for IN cord-302953-gr2kk9w4 226 3 Th17 Th17 NNP cord-302953-gr2kk9w4 226 4 cells cell NNS cord-302953-gr2kk9w4 227 1 ( ( -LRB- cord-302953-gr2kk9w4 227 2 Figure figure NN cord-302953-gr2kk9w4 227 3 8 8 CD cord-302953-gr2kk9w4 227 4 K K NNP cord-302953-gr2kk9w4 227 5 ) ) -RRB- cord-302953-gr2kk9w4 227 6 , , , cord-302953-gr2kk9w4 227 7 and and CC cord-302953-gr2kk9w4 227 8 Foxp3 Foxp3 VBN cord-302953-gr2kk9w4 227 9 for for IN cord-302953-gr2kk9w4 227 10 Tregs Tregs NNP cord-302953-gr2kk9w4 227 11 ( ( -LRB- cord-302953-gr2kk9w4 227 12 Figure Figure NNP cord-302953-gr2kk9w4 227 13 8L 8L NNP cord-302953-gr2kk9w4 227 14 ) ) -RRB- cord-302953-gr2kk9w4 227 15 was be VBD cord-302953-gr2kk9w4 227 16 also also RB cord-302953-gr2kk9w4 227 17 measured measure VBN cord-302953-gr2kk9w4 227 18 . . . cord-302953-gr2kk9w4 228 1 While while IN cord-302953-gr2kk9w4 228 2 significant significant JJ cord-302953-gr2kk9w4 228 3 differences difference NNS cord-302953-gr2kk9w4 228 4 were be VBD cord-302953-gr2kk9w4 228 5 found find VBN cord-302953-gr2kk9w4 228 6 between between IN cord-302953-gr2kk9w4 228 7 strains strain NNS cord-302953-gr2kk9w4 228 8 at at IN cord-302953-gr2kk9w4 228 9 various various JJ cord-302953-gr2kk9w4 228 10 time time NN cord-302953-gr2kk9w4 228 11 points point NNS cord-302953-gr2kk9w4 228 12 , , , cord-302953-gr2kk9w4 228 13 no no DT cord-302953-gr2kk9w4 228 14 major major JJ cord-302953-gr2kk9w4 228 15 trends trend NNS cord-302953-gr2kk9w4 228 16 were be VBD cord-302953-gr2kk9w4 228 17 identified identify VBN cord-302953-gr2kk9w4 228 18 . . . cord-302953-gr2kk9w4 229 1 Therefore therefore RB cord-302953-gr2kk9w4 229 2 , , , cord-302953-gr2kk9w4 229 3 CD4 CD4 NNP cord-302953-gr2kk9w4 229 4 + + CC cord-302953-gr2kk9w4 229 5 T t NN cord-302953-gr2kk9w4 229 6 cell cell NN cord-302953-gr2kk9w4 229 7 differentiation differentiation NN cord-302953-gr2kk9w4 229 8 mostly mostly RB cord-302953-gr2kk9w4 229 9 affected affect VBD cord-302953-gr2kk9w4 229 10 Ifng Ifng NNP cord-302953-gr2kk9w4 229 11 −/− −/− NNP cord-302953-gr2kk9w4 229 12 mice mouse NNS cord-302953-gr2kk9w4 229 13 with with IN cord-302953-gr2kk9w4 229 14 fewer few JJR cord-302953-gr2kk9w4 229 15 Th2 Th2 NNP cord-302953-gr2kk9w4 229 16 and and CC cord-302953-gr2kk9w4 229 17 Treg Treg NNP cord-302953-gr2kk9w4 229 18 cells cell NNS cord-302953-gr2kk9w4 229 19 and and CC cord-302953-gr2kk9w4 230 1 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 230 2 −/− −/− NNP cord-302953-gr2kk9w4 230 3 mice mouse NNS cord-302953-gr2kk9w4 230 4 with with IN cord-302953-gr2kk9w4 231 1 more more JJR cord-302953-gr2kk9w4 231 2 Th17 th17 CD cord-302953-gr2kk9w4 231 3 cells cell NNS cord-302953-gr2kk9w4 231 4 . . . cord-302953-gr2kk9w4 232 1 Modulation modulation NN cord-302953-gr2kk9w4 232 2 of of IN cord-302953-gr2kk9w4 232 3 Th Th NNP cord-302953-gr2kk9w4 232 4 profiles profile NNS cord-302953-gr2kk9w4 232 5 during during IN cord-302953-gr2kk9w4 232 6 SINV SINV NNP cord-302953-gr2kk9w4 232 7 infection infection NN cord-302953-gr2kk9w4 232 8 by by IN cord-302953-gr2kk9w4 232 9 IFN IFN NNP cord-302953-gr2kk9w4 232 10 - - HYPH cord-302953-gr2kk9w4 232 11 γ γ NNP cord-302953-gr2kk9w4 232 12 signaling signal VBG cord-302953-gr2kk9w4 232 13 warrants warrant NNS cord-302953-gr2kk9w4 232 14 further further JJ cord-302953-gr2kk9w4 232 15 examination examination NN cord-302953-gr2kk9w4 232 16 . . . cord-302953-gr2kk9w4 232 17 _SP cord-302953-gr2kk9w4 233 1 To to TO cord-302953-gr2kk9w4 233 2 examine examine VB cord-302953-gr2kk9w4 233 3 how how WRB cord-302953-gr2kk9w4 233 4 IFN IFN NNP cord-302953-gr2kk9w4 233 5 - - HYPH cord-302953-gr2kk9w4 233 6 γ γ NNP cord-302953-gr2kk9w4 233 7 signaling signaling NN cord-302953-gr2kk9w4 233 8 affects affect VBZ cord-302953-gr2kk9w4 233 9 CD8 CD8 NNP cord-302953-gr2kk9w4 233 10 + + CC cord-302953-gr2kk9w4 233 11 T t NN cord-302953-gr2kk9w4 233 12 cell cell NN cord-302953-gr2kk9w4 233 13 production production NN cord-302953-gr2kk9w4 233 14 of of IN cord-302953-gr2kk9w4 233 15 effector effector JJ cord-302953-gr2kk9w4 233 16 proteins protein NNS cord-302953-gr2kk9w4 233 17 at at IN cord-302953-gr2kk9w4 233 18 7 7 CD cord-302953-gr2kk9w4 233 19 DPI DPI NNP cord-302953-gr2kk9w4 233 20 , , , cord-302953-gr2kk9w4 233 21 IFN IFN NNP cord-302953-gr2kk9w4 233 22 - - HYPH cord-302953-gr2kk9w4 233 23 γ γ NNP cord-302953-gr2kk9w4 233 24 , , , cord-302953-gr2kk9w4 233 25 TNF TNF NNP cord-302953-gr2kk9w4 233 26 - - HYPH cord-302953-gr2kk9w4 233 27 α α NNP cord-302953-gr2kk9w4 233 28 , , , cord-302953-gr2kk9w4 233 29 GM GM NNP cord-302953-gr2kk9w4 233 30 - - HYPH cord-302953-gr2kk9w4 233 31 CSF CSF NNP cord-302953-gr2kk9w4 233 32 , , , cord-302953-gr2kk9w4 233 33 and and CC cord-302953-gr2kk9w4 233 34 granzyme granzyme NNP cord-302953-gr2kk9w4 233 35 B B NNP cord-302953-gr2kk9w4 233 36 in in IN cord-302953-gr2kk9w4 233 37 cells cell NNS cord-302953-gr2kk9w4 233 38 from from IN cord-302953-gr2kk9w4 233 39 the the DT cord-302953-gr2kk9w4 233 40 brains brain NNS cord-302953-gr2kk9w4 233 41 of of IN cord-302953-gr2kk9w4 233 42 WT WT NNP cord-302953-gr2kk9w4 233 43 , , , cord-302953-gr2kk9w4 233 44 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 233 45 −/− −/− NNP cord-302953-gr2kk9w4 233 46 , , , cord-302953-gr2kk9w4 233 47 and and CC cord-302953-gr2kk9w4 233 48 Ifng Ifng NNP cord-302953-gr2kk9w4 233 49 −/− −/− NNP cord-302953-gr2kk9w4 233 50 mice mouse NNS cord-302953-gr2kk9w4 233 51 were be VBD cord-302953-gr2kk9w4 233 52 examined examine VBN cord-302953-gr2kk9w4 233 53 by by IN cord-302953-gr2kk9w4 233 54 flow flow NN cord-302953-gr2kk9w4 233 55 cytometry cytometry NN cord-302953-gr2kk9w4 233 56 . . . cord-302953-gr2kk9w4 234 1 CD8 CD8 NNP cord-302953-gr2kk9w4 234 2 + + CC cord-302953-gr2kk9w4 234 3 T T NNP cord-302953-gr2kk9w4 234 4 cells cell NNS cord-302953-gr2kk9w4 234 5 from from IN cord-302953-gr2kk9w4 235 1 Ifng Ifng NNP cord-302953-gr2kk9w4 235 2 −/− −/− NNP cord-302953-gr2kk9w4 235 3 mice mouse NNS cord-302953-gr2kk9w4 235 4 did do VBD cord-302953-gr2kk9w4 235 5 not not RB cord-302953-gr2kk9w4 235 6 produce produce VB cord-302953-gr2kk9w4 235 7 IFN IFN NNP cord-302953-gr2kk9w4 235 8 - - HYPH cord-302953-gr2kk9w4 235 9 γ γ NNP cord-302953-gr2kk9w4 235 10 , , , cord-302953-gr2kk9w4 235 11 and and CC cord-302953-gr2kk9w4 235 12 the the DT cord-302953-gr2kk9w4 235 13 percentage percentage NN cord-302953-gr2kk9w4 235 14 of of IN cord-302953-gr2kk9w4 235 15 CD8 CD8 NNP cord-302953-gr2kk9w4 235 16 + + CC cord-302953-gr2kk9w4 235 17 T T NNP cord-302953-gr2kk9w4 235 18 cells cell NNS cord-302953-gr2kk9w4 235 19 producing produce VBG cord-302953-gr2kk9w4 235 20 IFN IFN NNP cord-302953-gr2kk9w4 235 21 - - HYPH cord-302953-gr2kk9w4 235 22 γ γ NNP cord-302953-gr2kk9w4 235 23 did do VBD cord-302953-gr2kk9w4 235 24 not not RB cord-302953-gr2kk9w4 235 25 differ differ VB cord-302953-gr2kk9w4 235 26 between between IN cord-302953-gr2kk9w4 235 27 WT WT NNP cord-302953-gr2kk9w4 235 28 and and CC cord-302953-gr2kk9w4 235 29 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 235 30 −/− −/− NNP cord-302953-gr2kk9w4 235 31 mice mouse NNS cord-302953-gr2kk9w4 236 1 ( ( -LRB- cord-302953-gr2kk9w4 236 2 Figure figure NN cord-302953-gr2kk9w4 236 3 9A 9a NN cord-302953-gr2kk9w4 236 4 ) ) -RRB- cord-302953-gr2kk9w4 236 5 . . . cord-302953-gr2kk9w4 237 1 The the DT cord-302953-gr2kk9w4 237 2 percentage percentage NN cord-302953-gr2kk9w4 237 3 of of IN cord-302953-gr2kk9w4 237 4 CD8 CD8 NNP cord-302953-gr2kk9w4 237 5 + + CC cord-302953-gr2kk9w4 237 6 T T NNP cord-302953-gr2kk9w4 237 7 cells cell NNS cord-302953-gr2kk9w4 237 8 producing produce VBG cord-302953-gr2kk9w4 237 9 TNF TNF NNP cord-302953-gr2kk9w4 237 10 - - HYPH cord-302953-gr2kk9w4 237 11 α α NNP cord-302953-gr2kk9w4 237 12 was be VBD cord-302953-gr2kk9w4 237 13 not not RB cord-302953-gr2kk9w4 237 14 significantly significantly RB cord-302953-gr2kk9w4 237 15 different different JJ cord-302953-gr2kk9w4 237 16 between between IN cord-302953-gr2kk9w4 237 17 strains strain NNS cord-302953-gr2kk9w4 237 18 ( ( -LRB- cord-302953-gr2kk9w4 237 19 Figure figure VB cord-302953-gr2kk9w4 237 20 _SP cord-302953-gr2kk9w4 237 21 9B 9b NN cord-302953-gr2kk9w4 237 22 ) ) -RRB- cord-302953-gr2kk9w4 237 23 , , , cord-302953-gr2kk9w4 237 24 but but CC cord-302953-gr2kk9w4 237 25 more more JJR cord-302953-gr2kk9w4 237 26 CD8 CD8 NNP cord-302953-gr2kk9w4 237 27 + + CC cord-302953-gr2kk9w4 237 28 T t NN cord-302953-gr2kk9w4 237 29 cells cell NNS cord-302953-gr2kk9w4 237 30 from from IN cord-302953-gr2kk9w4 237 31 WT WT NNP cord-302953-gr2kk9w4 237 32 mice mouse NNS cord-302953-gr2kk9w4 237 33 than than IN cord-302953-gr2kk9w4 237 34 Ifng Ifng NNP cord-302953-gr2kk9w4 237 35 −/− −/− NNP cord-302953-gr2kk9w4 237 36 mice mouse NNS cord-302953-gr2kk9w4 237 37 produced produce VBD cord-302953-gr2kk9w4 237 38 GM GM NNP cord-302953-gr2kk9w4 237 39 - - HYPH cord-302953-gr2kk9w4 237 40 CSF CSF NNP cord-302953-gr2kk9w4 237 41 ( ( -LRB- cord-302953-gr2kk9w4 237 42 Figure Figure NNP cord-302953-gr2kk9w4 237 43 9C 9c CD cord-302953-gr2kk9w4 237 44 ) ) -RRB- cord-302953-gr2kk9w4 237 45 , , , cord-302953-gr2kk9w4 237 46 while while IN cord-302953-gr2kk9w4 237 47 more more JJR cord-302953-gr2kk9w4 237 48 CD8 CD8 NNP cord-302953-gr2kk9w4 237 49 + + CC cord-302953-gr2kk9w4 237 50 T t NN cord-302953-gr2kk9w4 237 51 cells cell NNS cord-302953-gr2kk9w4 237 52 from from IN cord-302953-gr2kk9w4 237 53 both both DT cord-302953-gr2kk9w4 237 54 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 237 55 −/− −/− NNP cord-302953-gr2kk9w4 237 56 and and CC cord-302953-gr2kk9w4 237 57 Ifng Ifng NNP cord-302953-gr2kk9w4 237 58 −/− −/− NNP cord-302953-gr2kk9w4 237 59 mice mouse NNS cord-302953-gr2kk9w4 237 60 than than IN cord-302953-gr2kk9w4 237 61 WT WT NNP cord-302953-gr2kk9w4 237 62 mice mouse NNS cord-302953-gr2kk9w4 237 63 produced produce VBD cord-302953-gr2kk9w4 237 64 granzyme granzyme NNS cord-302953-gr2kk9w4 237 65 B B NNP cord-302953-gr2kk9w4 237 66 ( ( -LRB- cord-302953-gr2kk9w4 237 67 Figure figure NN cord-302953-gr2kk9w4 237 68 9D 9d CD cord-302953-gr2kk9w4 237 69 ) ) -RRB- cord-302953-gr2kk9w4 237 70 . . . cord-302953-gr2kk9w4 238 1 Furthermore furthermore RB cord-302953-gr2kk9w4 238 2 , , , cord-302953-gr2kk9w4 238 3 the the DT cord-302953-gr2kk9w4 238 4 granzyme granzyme NNS cord-302953-gr2kk9w4 238 5 B B NNP cord-302953-gr2kk9w4 238 6 MFI MFI NNP cord-302953-gr2kk9w4 238 7 of of IN cord-302953-gr2kk9w4 238 8 CD8 CD8 NNP cord-302953-gr2kk9w4 238 9 + + CC cord-302953-gr2kk9w4 238 10 T T NNP cord-302953-gr2kk9w4 238 11 cells cell NNS cord-302953-gr2kk9w4 238 12 from from IN cord-302953-gr2kk9w4 238 13 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 239 1 −/− −/− NNP cord-302953-gr2kk9w4 239 2 mice mouse NNS cord-302953-gr2kk9w4 239 3 was be VBD cord-302953-gr2kk9w4 239 4 also also RB cord-302953-gr2kk9w4 239 5 higher high JJR cord-302953-gr2kk9w4 239 6 than than IN cord-302953-gr2kk9w4 239 7 WT WT NNP cord-302953-gr2kk9w4 239 8 mice mouse NNS cord-302953-gr2kk9w4 239 9 ( ( -LRB- cord-302953-gr2kk9w4 239 10 Figure Figure NNP cord-302953-gr2kk9w4 239 11 9E 9E NNP cord-302953-gr2kk9w4 239 12 ) ) -RRB- cord-302953-gr2kk9w4 239 13 , , , cord-302953-gr2kk9w4 239 14 indicating indicate VBG cord-302953-gr2kk9w4 239 15 that that IN cord-302953-gr2kk9w4 239 16 individual individual JJ cord-302953-gr2kk9w4 239 17 CD8 CD8 NNP cord-302953-gr2kk9w4 239 18 + + CC cord-302953-gr2kk9w4 239 19 T T NNP cord-302953-gr2kk9w4 239 20 cells cell NNS cord-302953-gr2kk9w4 239 21 in in IN cord-302953-gr2kk9w4 239 22 the the DT cord-302953-gr2kk9w4 239 23 brains brain NNS cord-302953-gr2kk9w4 239 24 of of IN cord-302953-gr2kk9w4 239 25 mice mouse NNS cord-302953-gr2kk9w4 239 26 with with IN cord-302953-gr2kk9w4 239 27 impaired impaired JJ cord-302953-gr2kk9w4 239 28 IFN IFN NNP cord-302953-gr2kk9w4 239 29 - - HYPH cord-302953-gr2kk9w4 239 30 γ γ NNP cord-302953-gr2kk9w4 239 31 signaling signaling NN cord-302953-gr2kk9w4 239 32 produced produce VBD cord-302953-gr2kk9w4 239 33 more more JJR cord-302953-gr2kk9w4 239 34 granzyme granzyme NNS cord-302953-gr2kk9w4 239 35 B b NN cord-302953-gr2kk9w4 239 36 than than IN cord-302953-gr2kk9w4 239 37 cells cell NNS cord-302953-gr2kk9w4 239 38 with with IN cord-302953-gr2kk9w4 239 39 intact intact JJ cord-302953-gr2kk9w4 239 40 IFN IFN NNP cord-302953-gr2kk9w4 239 41 - - HYPH cord-302953-gr2kk9w4 239 42 γ γ NNP cord-302953-gr2kk9w4 239 43 signaling signaling NN cord-302953-gr2kk9w4 239 44 . . . cord-302953-gr2kk9w4 240 1 Expression expression NN cord-302953-gr2kk9w4 240 2 of of IN cord-302953-gr2kk9w4 240 3 granzyme granzyme NNS cord-302953-gr2kk9w4 240 4 A A NNP cord-302953-gr2kk9w4 240 5 ( ( -LRB- cord-302953-gr2kk9w4 240 6 Figure figure NN cord-302953-gr2kk9w4 240 7 9F 9f NN cord-302953-gr2kk9w4 240 8 ) ) -RRB- cord-302953-gr2kk9w4 240 9 and and CC cord-302953-gr2kk9w4 240 10 granzyme granzyme NNS cord-302953-gr2kk9w4 240 11 B B NNP cord-302953-gr2kk9w4 240 12 ( ( -LRB- cord-302953-gr2kk9w4 240 13 Figure figure NN cord-302953-gr2kk9w4 240 14 9 9 CD cord-302953-gr2kk9w4 240 15 G g NN cord-302953-gr2kk9w4 240 16 ) ) -RRB- cord-302953-gr2kk9w4 240 17 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 240 18 in in IN cord-302953-gr2kk9w4 240 19 brain brain NN cord-302953-gr2kk9w4 240 20 was be VBD cord-302953-gr2kk9w4 240 21 lower low JJR cord-302953-gr2kk9w4 240 22 in in IN cord-302953-gr2kk9w4 241 1 Ifng Ifng NNP cord-302953-gr2kk9w4 241 2 −/− −/− NNP cord-302953-gr2kk9w4 241 3 mice mouse NNS cord-302953-gr2kk9w4 241 4 compared compare VBN cord-302953-gr2kk9w4 241 5 to to IN cord-302953-gr2kk9w4 241 6 WT WT NNP cord-302953-gr2kk9w4 241 7 and and CC cord-302953-gr2kk9w4 241 8 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 241 9 −/− −/− NNP cord-302953-gr2kk9w4 241 10 mice mouse NNS cord-302953-gr2kk9w4 241 11 , , , cord-302953-gr2kk9w4 241 12 but but CC cord-302953-gr2kk9w4 241 13 expression expression NN cord-302953-gr2kk9w4 241 14 differences difference NNS cord-302953-gr2kk9w4 241 15 among among IN cord-302953-gr2kk9w4 241 16 strains strain NNS cord-302953-gr2kk9w4 241 17 for for IN cord-302953-gr2kk9w4 241 18 granzyme granzyme NNS cord-302953-gr2kk9w4 241 19 K K NNP cord-302953-gr2kk9w4 241 20 ( ( -LRB- cord-302953-gr2kk9w4 241 21 Figure Figure NNP cord-302953-gr2kk9w4 241 22 9H 9h CD cord-302953-gr2kk9w4 241 23 ) ) -RRB- cord-302953-gr2kk9w4 241 24 , , , cord-302953-gr2kk9w4 241 25 granzyme granzyme NNP cord-302953-gr2kk9w4 241 26 M M NNP cord-302953-gr2kk9w4 241 27 ( ( -LRB- cord-302953-gr2kk9w4 241 28 Figure Figure NNP cord-302953-gr2kk9w4 241 29 9I 9i NN cord-302953-gr2kk9w4 241 30 ) ) -RRB- cord-302953-gr2kk9w4 241 31 , , , cord-302953-gr2kk9w4 241 32 and and CC cord-302953-gr2kk9w4 241 33 perforin perforin NNP cord-302953-gr2kk9w4 241 34 ( ( -LRB- cord-302953-gr2kk9w4 241 35 Figure figure NN cord-302953-gr2kk9w4 241 36 9J 9j CD cord-302953-gr2kk9w4 241 37 ) ) -RRB- cord-302953-gr2kk9w4 241 38 were be VBD cord-302953-gr2kk9w4 241 39 less less RBR cord-302953-gr2kk9w4 241 40 pronounced pronounced JJ cord-302953-gr2kk9w4 241 41 . . . cord-302953-gr2kk9w4 242 1 Effector effector NN cord-302953-gr2kk9w4 242 2 function function NN cord-302953-gr2kk9w4 242 3 of of IN cord-302953-gr2kk9w4 242 4 CD8 CD8 NNP cord-302953-gr2kk9w4 242 5 + + CC cord-302953-gr2kk9w4 242 6 T T NNP cord-302953-gr2kk9w4 242 7 cells cell NNS cord-302953-gr2kk9w4 242 8 in in IN cord-302953-gr2kk9w4 242 9 the the DT cord-302953-gr2kk9w4 242 10 spinal spinal JJ cord-302953-gr2kk9w4 242 11 cords cord NNS cord-302953-gr2kk9w4 242 12 of of IN cord-302953-gr2kk9w4 242 13 infected infected JJ cord-302953-gr2kk9w4 242 14 mice mouse NNS cord-302953-gr2kk9w4 242 15 were be VBD cord-302953-gr2kk9w4 242 16 similar similar JJ cord-302953-gr2kk9w4 242 17 to to IN cord-302953-gr2kk9w4 242 18 the the DT cord-302953-gr2kk9w4 242 19 brain brain NN cord-302953-gr2kk9w4 242 20 in in IN cord-302953-gr2kk9w4 242 21 that that DT cord-302953-gr2kk9w4 243 1 IFN IFN NNP cord-302953-gr2kk9w4 243 2 - - HYPH cord-302953-gr2kk9w4 243 3 γ γ NNP cord-302953-gr2kk9w4 243 4 - - HYPH cord-302953-gr2kk9w4 243 5 producing produce VBG cord-302953-gr2kk9w4 243 6 CD8 CD8 NNP cord-302953-gr2kk9w4 243 7 + + CC cord-302953-gr2kk9w4 243 8 T t NN cord-302953-gr2kk9w4 243 9 cells cell NNS cord-302953-gr2kk9w4 243 10 were be VBD cord-302953-gr2kk9w4 243 11 not not RB cord-302953-gr2kk9w4 243 12 detected detect VBN cord-302953-gr2kk9w4 243 13 in in IN cord-302953-gr2kk9w4 243 14 Ifng Ifng NNP cord-302953-gr2kk9w4 243 15 −/− −/− NNP cord-302953-gr2kk9w4 243 16 mice mouse NNS cord-302953-gr2kk9w4 243 17 and and CC cord-302953-gr2kk9w4 243 18 were be VBD cord-302953-gr2kk9w4 243 19 comparable comparable JJ cord-302953-gr2kk9w4 243 20 between between IN cord-302953-gr2kk9w4 243 21 WT WT NNP cord-302953-gr2kk9w4 243 22 and and CC cord-302953-gr2kk9w4 243 23 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 243 24 −/− −/− NNP cord-302953-gr2kk9w4 243 25 mice mouse NNS cord-302953-gr2kk9w4 244 1 ( ( -LRB- cord-302953-gr2kk9w4 244 2 Figure figure NN cord-302953-gr2kk9w4 244 3 9 9 CD cord-302953-gr2kk9w4 244 4 K K NNP cord-302953-gr2kk9w4 244 5 ) ) -RRB- cord-302953-gr2kk9w4 244 6 . . . cord-302953-gr2kk9w4 245 1 TNF TNF NNP cord-302953-gr2kk9w4 245 2 - - HYPH cord-302953-gr2kk9w4 245 3 α α NNP cord-302953-gr2kk9w4 245 4 ( ( -LRB- cord-302953-gr2kk9w4 245 5 Figure Figure NNP cord-302953-gr2kk9w4 245 6 9L 9l CD cord-302953-gr2kk9w4 245 7 ) ) -RRB- cord-302953-gr2kk9w4 245 8 and and CC cord-302953-gr2kk9w4 246 1 GM GM NNP cord-302953-gr2kk9w4 246 2 - - HYPH cord-302953-gr2kk9w4 246 3 CSF CSF NNP cord-302953-gr2kk9w4 246 4 ( ( -LRB- cord-302953-gr2kk9w4 246 5 Figure Figure NNP cord-302953-gr2kk9w4 246 6 9 9 CD cord-302953-gr2kk9w4 246 7 M M NNP cord-302953-gr2kk9w4 246 8 ) ) -RRB- cord-302953-gr2kk9w4 246 9 production production NN cord-302953-gr2kk9w4 246 10 by by IN cord-302953-gr2kk9w4 246 11 CD8 CD8 NNP cord-302953-gr2kk9w4 246 12 + + CC cord-302953-gr2kk9w4 246 13 _SP cord-302953-gr2kk9w4 247 1 To to TO cord-302953-gr2kk9w4 247 2 examine examine VB cord-302953-gr2kk9w4 247 3 how how WRB cord-302953-gr2kk9w4 247 4 IFN IFN NNP cord-302953-gr2kk9w4 247 5 - - HYPH cord-302953-gr2kk9w4 247 6 γ γ NNP cord-302953-gr2kk9w4 247 7 signaling signaling NN cord-302953-gr2kk9w4 247 8 affects affect VBZ cord-302953-gr2kk9w4 247 9 CD8 CD8 NNP cord-302953-gr2kk9w4 247 10 + + CC cord-302953-gr2kk9w4 247 11 T t NN cord-302953-gr2kk9w4 247 12 cell cell NN cord-302953-gr2kk9w4 247 13 production production NN cord-302953-gr2kk9w4 247 14 of of IN cord-302953-gr2kk9w4 247 15 effector effector JJ cord-302953-gr2kk9w4 247 16 proteins protein NNS cord-302953-gr2kk9w4 247 17 at at IN cord-302953-gr2kk9w4 247 18 7 7 CD cord-302953-gr2kk9w4 247 19 DPI DPI NNP cord-302953-gr2kk9w4 247 20 , , , cord-302953-gr2kk9w4 247 21 IFN IFN NNP cord-302953-gr2kk9w4 247 22 - - HYPH cord-302953-gr2kk9w4 247 23 γ γ NNP cord-302953-gr2kk9w4 247 24 , , , cord-302953-gr2kk9w4 247 25 TNF TNF NNP cord-302953-gr2kk9w4 247 26 - - HYPH cord-302953-gr2kk9w4 247 27 α α NNP cord-302953-gr2kk9w4 247 28 , , , cord-302953-gr2kk9w4 247 29 GM GM NNP cord-302953-gr2kk9w4 247 30 - - HYPH cord-302953-gr2kk9w4 247 31 CSF CSF NNP cord-302953-gr2kk9w4 247 32 , , , cord-302953-gr2kk9w4 247 33 and and CC cord-302953-gr2kk9w4 247 34 granzyme granzyme NNP cord-302953-gr2kk9w4 247 35 B B NNP cord-302953-gr2kk9w4 247 36 in in IN cord-302953-gr2kk9w4 247 37 cells cell NNS cord-302953-gr2kk9w4 247 38 from from IN cord-302953-gr2kk9w4 247 39 the the DT cord-302953-gr2kk9w4 247 40 brains brain NNS cord-302953-gr2kk9w4 247 41 of of IN cord-302953-gr2kk9w4 247 42 WT WT NNP cord-302953-gr2kk9w4 247 43 , , , cord-302953-gr2kk9w4 247 44 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 247 45 −/− −/− NNP cord-302953-gr2kk9w4 247 46 , , , cord-302953-gr2kk9w4 247 47 and and CC cord-302953-gr2kk9w4 247 48 Ifng Ifng NNP cord-302953-gr2kk9w4 247 49 −/− −/− NNP cord-302953-gr2kk9w4 247 50 mice mouse NNS cord-302953-gr2kk9w4 247 51 were be VBD cord-302953-gr2kk9w4 247 52 examined examine VBN cord-302953-gr2kk9w4 247 53 by by IN cord-302953-gr2kk9w4 247 54 flow flow NN cord-302953-gr2kk9w4 247 55 cytometry cytometry NN cord-302953-gr2kk9w4 247 56 . . . cord-302953-gr2kk9w4 248 1 CD8 CD8 NNP cord-302953-gr2kk9w4 248 2 + + CC cord-302953-gr2kk9w4 248 3 T T NNP cord-302953-gr2kk9w4 248 4 cells cell NNS cord-302953-gr2kk9w4 248 5 from from IN cord-302953-gr2kk9w4 249 1 Ifng Ifng NNP cord-302953-gr2kk9w4 249 2 −/− −/− NNP cord-302953-gr2kk9w4 249 3 mice mouse NNS cord-302953-gr2kk9w4 249 4 did do VBD cord-302953-gr2kk9w4 249 5 not not RB cord-302953-gr2kk9w4 249 6 produce produce VB cord-302953-gr2kk9w4 249 7 IFN IFN NNP cord-302953-gr2kk9w4 249 8 - - HYPH cord-302953-gr2kk9w4 249 9 γ γ NNP cord-302953-gr2kk9w4 249 10 , , , cord-302953-gr2kk9w4 249 11 and and CC cord-302953-gr2kk9w4 249 12 the the DT cord-302953-gr2kk9w4 249 13 percentage percentage NN cord-302953-gr2kk9w4 249 14 of of IN cord-302953-gr2kk9w4 249 15 CD8 CD8 NNP cord-302953-gr2kk9w4 249 16 + + CC cord-302953-gr2kk9w4 249 17 T T NNP cord-302953-gr2kk9w4 249 18 cells cell NNS cord-302953-gr2kk9w4 249 19 producing produce VBG cord-302953-gr2kk9w4 249 20 IFN IFN NNP cord-302953-gr2kk9w4 249 21 - - HYPH cord-302953-gr2kk9w4 249 22 γ γ NNP cord-302953-gr2kk9w4 249 23 did do VBD cord-302953-gr2kk9w4 249 24 not not RB cord-302953-gr2kk9w4 249 25 differ differ VB cord-302953-gr2kk9w4 249 26 between between IN cord-302953-gr2kk9w4 249 27 WT WT NNP cord-302953-gr2kk9w4 249 28 and and CC cord-302953-gr2kk9w4 249 29 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 249 30 −/− −/− NNP cord-302953-gr2kk9w4 249 31 mice mouse NNS cord-302953-gr2kk9w4 250 1 ( ( -LRB- cord-302953-gr2kk9w4 250 2 Figure figure NN cord-302953-gr2kk9w4 250 3 9A 9a NN cord-302953-gr2kk9w4 250 4 ) ) -RRB- cord-302953-gr2kk9w4 250 5 . . . cord-302953-gr2kk9w4 251 1 The the DT cord-302953-gr2kk9w4 251 2 percentage percentage NN cord-302953-gr2kk9w4 251 3 of of IN cord-302953-gr2kk9w4 251 4 CD8 CD8 NNP cord-302953-gr2kk9w4 251 5 + + CC cord-302953-gr2kk9w4 251 6 T T NNP cord-302953-gr2kk9w4 251 7 cells cell NNS cord-302953-gr2kk9w4 251 8 producing produce VBG cord-302953-gr2kk9w4 251 9 TNF TNF NNP cord-302953-gr2kk9w4 251 10 - - HYPH cord-302953-gr2kk9w4 251 11 α α NNP cord-302953-gr2kk9w4 251 12 was be VBD cord-302953-gr2kk9w4 251 13 not not RB cord-302953-gr2kk9w4 251 14 significantly significantly RB cord-302953-gr2kk9w4 251 15 different different JJ cord-302953-gr2kk9w4 251 16 between between IN cord-302953-gr2kk9w4 251 17 strains strain NNS cord-302953-gr2kk9w4 251 18 ( ( -LRB- cord-302953-gr2kk9w4 251 19 Figure figure NN cord-302953-gr2kk9w4 251 20 9B 9b CD cord-302953-gr2kk9w4 251 21 ) ) -RRB- cord-302953-gr2kk9w4 251 22 , , , cord-302953-gr2kk9w4 251 23 but but CC cord-302953-gr2kk9w4 251 24 more more JJR cord-302953-gr2kk9w4 251 25 CD8 CD8 NNP cord-302953-gr2kk9w4 251 26 + + CC cord-302953-gr2kk9w4 251 27 T t NN cord-302953-gr2kk9w4 251 28 cells cell NNS cord-302953-gr2kk9w4 251 29 from from IN cord-302953-gr2kk9w4 251 30 WT WT NNP cord-302953-gr2kk9w4 251 31 mice mouse NNS cord-302953-gr2kk9w4 251 32 than than IN cord-302953-gr2kk9w4 251 33 Ifng Ifng NNP cord-302953-gr2kk9w4 251 34 −/− −/− NNP cord-302953-gr2kk9w4 251 35 mice mouse NNS cord-302953-gr2kk9w4 251 36 produced produce VBD cord-302953-gr2kk9w4 251 37 GM GM NNP cord-302953-gr2kk9w4 251 38 - - HYPH cord-302953-gr2kk9w4 251 39 CSF CSF NNP cord-302953-gr2kk9w4 251 40 ( ( -LRB- cord-302953-gr2kk9w4 251 41 Figure Figure NNP cord-302953-gr2kk9w4 251 42 9C 9c CD cord-302953-gr2kk9w4 251 43 ) ) -RRB- cord-302953-gr2kk9w4 251 44 , , , cord-302953-gr2kk9w4 251 45 while while IN cord-302953-gr2kk9w4 251 46 more more JJR cord-302953-gr2kk9w4 251 47 CD8 CD8 NNP cord-302953-gr2kk9w4 251 48 + + CC cord-302953-gr2kk9w4 251 49 T t NN cord-302953-gr2kk9w4 251 50 cells cell NNS cord-302953-gr2kk9w4 251 51 from from IN cord-302953-gr2kk9w4 251 52 both both DT cord-302953-gr2kk9w4 251 53 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 251 54 −/− −/− NNP cord-302953-gr2kk9w4 251 55 and and CC cord-302953-gr2kk9w4 251 56 Ifng Ifng NNP cord-302953-gr2kk9w4 251 57 −/− −/− NNP cord-302953-gr2kk9w4 251 58 mice mouse NNS cord-302953-gr2kk9w4 251 59 than than IN cord-302953-gr2kk9w4 251 60 WT WT NNP cord-302953-gr2kk9w4 251 61 mice mouse NNS cord-302953-gr2kk9w4 251 62 produced produce VBD cord-302953-gr2kk9w4 251 63 granzyme granzyme NNS cord-302953-gr2kk9w4 251 64 B B NNP cord-302953-gr2kk9w4 251 65 ( ( -LRB- cord-302953-gr2kk9w4 251 66 Figure figure NN cord-302953-gr2kk9w4 251 67 9D 9d CD cord-302953-gr2kk9w4 251 68 ) ) -RRB- cord-302953-gr2kk9w4 251 69 . . . cord-302953-gr2kk9w4 252 1 Furthermore furthermore RB cord-302953-gr2kk9w4 252 2 , , , cord-302953-gr2kk9w4 252 3 the the DT cord-302953-gr2kk9w4 252 4 granzyme granzyme NNS cord-302953-gr2kk9w4 252 5 B B NNP cord-302953-gr2kk9w4 252 6 MFI MFI NNP cord-302953-gr2kk9w4 252 7 of of IN cord-302953-gr2kk9w4 252 8 CD8 CD8 NNP cord-302953-gr2kk9w4 252 9 + + CC cord-302953-gr2kk9w4 252 10 T T NNP cord-302953-gr2kk9w4 252 11 cells cell NNS cord-302953-gr2kk9w4 252 12 from from IN cord-302953-gr2kk9w4 252 13 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 253 1 −/− −/− NNP cord-302953-gr2kk9w4 253 2 mice mouse NNS cord-302953-gr2kk9w4 253 3 was be VBD cord-302953-gr2kk9w4 253 4 also also RB cord-302953-gr2kk9w4 253 5 higher high JJR cord-302953-gr2kk9w4 253 6 than than IN cord-302953-gr2kk9w4 253 7 WT WT NNP cord-302953-gr2kk9w4 253 8 mice mouse NNS cord-302953-gr2kk9w4 253 9 ( ( -LRB- cord-302953-gr2kk9w4 253 10 Figure Figure NNP cord-302953-gr2kk9w4 253 11 9E 9E NNP cord-302953-gr2kk9w4 253 12 ) ) -RRB- cord-302953-gr2kk9w4 253 13 , , , cord-302953-gr2kk9w4 253 14 indicating indicate VBG cord-302953-gr2kk9w4 253 15 that that IN cord-302953-gr2kk9w4 253 16 individual individual JJ cord-302953-gr2kk9w4 253 17 CD8 CD8 NNP cord-302953-gr2kk9w4 253 18 + + CC cord-302953-gr2kk9w4 253 19 T T NNP cord-302953-gr2kk9w4 253 20 cells cell NNS cord-302953-gr2kk9w4 253 21 in in IN cord-302953-gr2kk9w4 253 22 the the DT cord-302953-gr2kk9w4 253 23 brains brain NNS cord-302953-gr2kk9w4 253 24 of of IN cord-302953-gr2kk9w4 253 25 mice mouse NNS cord-302953-gr2kk9w4 253 26 with with IN cord-302953-gr2kk9w4 253 27 impaired impaired JJ cord-302953-gr2kk9w4 253 28 IFN IFN NNP cord-302953-gr2kk9w4 253 29 - - HYPH cord-302953-gr2kk9w4 253 30 γ γ NNP cord-302953-gr2kk9w4 253 31 signaling signaling NN cord-302953-gr2kk9w4 253 32 produced produce VBD cord-302953-gr2kk9w4 253 33 more more JJR cord-302953-gr2kk9w4 253 34 granzyme granzyme NNS cord-302953-gr2kk9w4 253 35 B b NN cord-302953-gr2kk9w4 253 36 than than IN cord-302953-gr2kk9w4 253 37 cells cell NNS cord-302953-gr2kk9w4 253 38 with with IN cord-302953-gr2kk9w4 253 39 intact intact JJ cord-302953-gr2kk9w4 253 40 IFN IFN NNP cord-302953-gr2kk9w4 253 41 - - HYPH cord-302953-gr2kk9w4 253 42 γ γ NNP cord-302953-gr2kk9w4 253 43 signaling signaling NN cord-302953-gr2kk9w4 253 44 . . . cord-302953-gr2kk9w4 254 1 Expression expression NN cord-302953-gr2kk9w4 254 2 of of IN cord-302953-gr2kk9w4 254 3 granzyme granzyme NNS cord-302953-gr2kk9w4 254 4 A A NNP cord-302953-gr2kk9w4 254 5 ( ( -LRB- cord-302953-gr2kk9w4 254 6 Figure figure NN cord-302953-gr2kk9w4 254 7 9F 9f NN cord-302953-gr2kk9w4 254 8 ) ) -RRB- cord-302953-gr2kk9w4 254 9 and and CC cord-302953-gr2kk9w4 254 10 granzyme granzyme NNS cord-302953-gr2kk9w4 254 11 B B NNP cord-302953-gr2kk9w4 254 12 ( ( -LRB- cord-302953-gr2kk9w4 254 13 Figure figure NN cord-302953-gr2kk9w4 254 14 9 9 CD cord-302953-gr2kk9w4 254 15 G g NN cord-302953-gr2kk9w4 254 16 ) ) -RRB- cord-302953-gr2kk9w4 254 17 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 254 18 in in IN cord-302953-gr2kk9w4 254 19 brain brain NN cord-302953-gr2kk9w4 254 20 was be VBD cord-302953-gr2kk9w4 254 21 lower low JJR cord-302953-gr2kk9w4 254 22 in in IN cord-302953-gr2kk9w4 255 1 Ifng Ifng NNP cord-302953-gr2kk9w4 255 2 −/− −/− NNP cord-302953-gr2kk9w4 255 3 mice mouse NNS cord-302953-gr2kk9w4 255 4 compared compare VBN cord-302953-gr2kk9w4 255 5 to to IN cord-302953-gr2kk9w4 255 6 WT WT NNP cord-302953-gr2kk9w4 255 7 and and CC cord-302953-gr2kk9w4 255 8 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 255 9 −/− −/− NNP cord-302953-gr2kk9w4 255 10 mice mouse NNS cord-302953-gr2kk9w4 255 11 , , , cord-302953-gr2kk9w4 255 12 but but CC cord-302953-gr2kk9w4 255 13 expression expression NN cord-302953-gr2kk9w4 255 14 differences difference NNS cord-302953-gr2kk9w4 255 15 among among IN cord-302953-gr2kk9w4 255 16 strains strain NNS cord-302953-gr2kk9w4 255 17 for for IN cord-302953-gr2kk9w4 255 18 granzyme granzyme NNS cord-302953-gr2kk9w4 255 19 K K NNP cord-302953-gr2kk9w4 255 20 ( ( -LRB- cord-302953-gr2kk9w4 255 21 Figure Figure NNP cord-302953-gr2kk9w4 255 22 9H 9h CD cord-302953-gr2kk9w4 255 23 ) ) -RRB- cord-302953-gr2kk9w4 255 24 , , , cord-302953-gr2kk9w4 255 25 granzyme granzyme NNP cord-302953-gr2kk9w4 255 26 M M NNP cord-302953-gr2kk9w4 255 27 ( ( -LRB- cord-302953-gr2kk9w4 255 28 Figure Figure NNP cord-302953-gr2kk9w4 255 29 9I 9i NN cord-302953-gr2kk9w4 255 30 ) ) -RRB- cord-302953-gr2kk9w4 255 31 , , , cord-302953-gr2kk9w4 255 32 and and CC cord-302953-gr2kk9w4 255 33 perforin perforin NNP cord-302953-gr2kk9w4 255 34 ( ( -LRB- cord-302953-gr2kk9w4 255 35 Figure figure NN cord-302953-gr2kk9w4 255 36 9J 9j CD cord-302953-gr2kk9w4 255 37 ) ) -RRB- cord-302953-gr2kk9w4 255 38 were be VBD cord-302953-gr2kk9w4 255 39 less less RBR cord-302953-gr2kk9w4 255 40 pronounced pronounced JJ cord-302953-gr2kk9w4 255 41 . . . cord-302953-gr2kk9w4 256 1 T t NN cord-302953-gr2kk9w4 256 2 cells cell NNS cord-302953-gr2kk9w4 256 3 were be VBD cord-302953-gr2kk9w4 256 4 not not RB cord-302953-gr2kk9w4 256 5 different different JJ cord-302953-gr2kk9w4 256 6 , , , cord-302953-gr2kk9w4 256 7 but but CC cord-302953-gr2kk9w4 256 8 the the DT cord-302953-gr2kk9w4 256 9 percentage percentage NN cord-302953-gr2kk9w4 256 10 of of IN cord-302953-gr2kk9w4 256 11 CD8 CD8 NNP cord-302953-gr2kk9w4 256 12 + + CC cord-302953-gr2kk9w4 256 13 T T NNP cord-302953-gr2kk9w4 256 14 cells cell NNS cord-302953-gr2kk9w4 256 15 producing produce VBG cord-302953-gr2kk9w4 256 16 granzyme granzyme NNS cord-302953-gr2kk9w4 256 17 B B NNP cord-302953-gr2kk9w4 256 18 ( ( -LRB- cord-302953-gr2kk9w4 256 19 Figure figure NN cord-302953-gr2kk9w4 256 20 9N 9n CD cord-302953-gr2kk9w4 256 21 ) ) -RRB- cord-302953-gr2kk9w4 256 22 was be VBD cord-302953-gr2kk9w4 256 23 lower low JJR cord-302953-gr2kk9w4 256 24 in in IN cord-302953-gr2kk9w4 256 25 WT WT NNP cord-302953-gr2kk9w4 256 26 mice mouse NNS cord-302953-gr2kk9w4 256 27 than than IN cord-302953-gr2kk9w4 256 28 mice mouse NNS cord-302953-gr2kk9w4 256 29 with with IN cord-302953-gr2kk9w4 256 30 impaired impaired JJ cord-302953-gr2kk9w4 256 31 IFN IFN NNP cord-302953-gr2kk9w4 256 32 - - HYPH cord-302953-gr2kk9w4 256 33 γ γ NNP cord-302953-gr2kk9w4 256 34 signaling signaling NN cord-302953-gr2kk9w4 256 35 . . . cord-302953-gr2kk9w4 257 1 These these DT cord-302953-gr2kk9w4 257 2 findings finding NNS cord-302953-gr2kk9w4 257 3 indicate indicate VBP cord-302953-gr2kk9w4 257 4 that that IN cord-302953-gr2kk9w4 257 5 IFN IFN NNP cord-302953-gr2kk9w4 257 6 - - HYPH cord-302953-gr2kk9w4 257 7 γ γ NNP cord-302953-gr2kk9w4 257 8 signaling signal VBG cord-302953-gr2kk9w4 257 9 not not RB cord-302953-gr2kk9w4 257 10 only only RB cord-302953-gr2kk9w4 257 11 inhibits inhibit VBZ cord-302953-gr2kk9w4 257 12 infiltration infiltration NN cord-302953-gr2kk9w4 257 13 of of IN cord-302953-gr2kk9w4 257 14 CD8 CD8 NNP cord-302953-gr2kk9w4 257 15 + + CC cord-302953-gr2kk9w4 257 16 T T NNP cord-302953-gr2kk9w4 257 17 cells cell NNS cord-302953-gr2kk9w4 257 18 into into IN cord-302953-gr2kk9w4 257 19 the the DT cord-302953-gr2kk9w4 257 20 CNS CNS NNP cord-302953-gr2kk9w4 257 21 , , , cord-302953-gr2kk9w4 257 22 but but CC cord-302953-gr2kk9w4 257 23 also also RB cord-302953-gr2kk9w4 257 24 inhibits inhibit VBZ cord-302953-gr2kk9w4 257 25 CD8 CD8 NNP cord-302953-gr2kk9w4 257 26 + + CC cord-302953-gr2kk9w4 257 27 T T NNP cord-302953-gr2kk9w4 257 28 cell cell NN cord-302953-gr2kk9w4 257 29 synthesis synthesis NN cord-302953-gr2kk9w4 257 30 of of IN cord-302953-gr2kk9w4 257 31 granzyme granzyme NNP cord-302953-gr2kk9w4 257 32 B. B. NNP cord-302953-gr2kk9w4 257 33 Effector Effector NNP cord-302953-gr2kk9w4 257 34 function function NN cord-302953-gr2kk9w4 257 35 of of IN cord-302953-gr2kk9w4 257 36 CD8 CD8 NNP cord-302953-gr2kk9w4 257 37 + + CC cord-302953-gr2kk9w4 257 38 T T NNP cord-302953-gr2kk9w4 257 39 cells cell NNS cord-302953-gr2kk9w4 257 40 in in IN cord-302953-gr2kk9w4 257 41 the the DT cord-302953-gr2kk9w4 257 42 spinal spinal JJ cord-302953-gr2kk9w4 257 43 cords cord NNS cord-302953-gr2kk9w4 257 44 of of IN cord-302953-gr2kk9w4 257 45 infected infected JJ cord-302953-gr2kk9w4 257 46 mice mouse NNS cord-302953-gr2kk9w4 257 47 were be VBD cord-302953-gr2kk9w4 257 48 similar similar JJ cord-302953-gr2kk9w4 257 49 to to IN cord-302953-gr2kk9w4 257 50 the the DT cord-302953-gr2kk9w4 257 51 brain brain NN cord-302953-gr2kk9w4 257 52 in in IN cord-302953-gr2kk9w4 257 53 that that DT cord-302953-gr2kk9w4 258 1 IFN IFN NNP cord-302953-gr2kk9w4 258 2 - - HYPH cord-302953-gr2kk9w4 258 3 γ γ NNP cord-302953-gr2kk9w4 258 4 - - HYPH cord-302953-gr2kk9w4 258 5 producing produce VBG cord-302953-gr2kk9w4 258 6 CD8 CD8 NNP cord-302953-gr2kk9w4 258 7 + + CC cord-302953-gr2kk9w4 258 8 T t NN cord-302953-gr2kk9w4 258 9 cells cell NNS cord-302953-gr2kk9w4 258 10 were be VBD cord-302953-gr2kk9w4 258 11 not not RB cord-302953-gr2kk9w4 258 12 detected detect VBN cord-302953-gr2kk9w4 258 13 in in IN cord-302953-gr2kk9w4 258 14 Ifng Ifng NNP cord-302953-gr2kk9w4 258 15 −/− −/− NNP cord-302953-gr2kk9w4 258 16 mice mouse NNS cord-302953-gr2kk9w4 258 17 and and CC cord-302953-gr2kk9w4 258 18 were be VBD cord-302953-gr2kk9w4 258 19 comparable comparable JJ cord-302953-gr2kk9w4 258 20 between between IN cord-302953-gr2kk9w4 258 21 WT WT NNP cord-302953-gr2kk9w4 258 22 and and CC cord-302953-gr2kk9w4 258 23 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 258 24 −/− −/− NNP cord-302953-gr2kk9w4 258 25 mice mouse NNS cord-302953-gr2kk9w4 259 1 ( ( -LRB- cord-302953-gr2kk9w4 259 2 Figure figure NN cord-302953-gr2kk9w4 259 3 9 9 CD cord-302953-gr2kk9w4 259 4 K K NNP cord-302953-gr2kk9w4 259 5 ) ) -RRB- cord-302953-gr2kk9w4 259 6 . . . cord-302953-gr2kk9w4 260 1 TNF TNF NNP cord-302953-gr2kk9w4 260 2 - - HYPH cord-302953-gr2kk9w4 260 3 α α NNP cord-302953-gr2kk9w4 260 4 ( ( -LRB- cord-302953-gr2kk9w4 260 5 Figure Figure NNP cord-302953-gr2kk9w4 260 6 9L 9l CD cord-302953-gr2kk9w4 260 7 ) ) -RRB- cord-302953-gr2kk9w4 260 8 and and CC cord-302953-gr2kk9w4 260 9 GM GM NNP cord-302953-gr2kk9w4 260 10 - - HYPH cord-302953-gr2kk9w4 260 11 CSF CSF NNP cord-302953-gr2kk9w4 260 12 ( ( -LRB- cord-302953-gr2kk9w4 260 13 Figure Figure NNP cord-302953-gr2kk9w4 260 14 9 9 CD cord-302953-gr2kk9w4 260 15 M M NNP cord-302953-gr2kk9w4 260 16 ) ) -RRB- cord-302953-gr2kk9w4 260 17 production production NN cord-302953-gr2kk9w4 260 18 by by IN cord-302953-gr2kk9w4 260 19 CD8 CD8 NNP cord-302953-gr2kk9w4 261 1 + + CC cord-302953-gr2kk9w4 262 1 T t NN cord-302953-gr2kk9w4 262 2 cells cell NNS cord-302953-gr2kk9w4 262 3 were be VBD cord-302953-gr2kk9w4 262 4 not not RB cord-302953-gr2kk9w4 262 5 different different JJ cord-302953-gr2kk9w4 262 6 , , , cord-302953-gr2kk9w4 262 7 but but CC cord-302953-gr2kk9w4 262 8 the the DT cord-302953-gr2kk9w4 262 9 percentage percentage NN cord-302953-gr2kk9w4 262 10 of of IN cord-302953-gr2kk9w4 262 11 CD8 CD8 NNP cord-302953-gr2kk9w4 262 12 + + CC cord-302953-gr2kk9w4 262 13 T T NNP cord-302953-gr2kk9w4 262 14 cells cell NNS cord-302953-gr2kk9w4 262 15 producing produce VBG cord-302953-gr2kk9w4 262 16 granzyme granzyme NNS cord-302953-gr2kk9w4 262 17 B B NNP cord-302953-gr2kk9w4 262 18 ( ( -LRB- cord-302953-gr2kk9w4 262 19 Figure figure NN cord-302953-gr2kk9w4 262 20 9N 9n CD cord-302953-gr2kk9w4 262 21 ) ) -RRB- cord-302953-gr2kk9w4 262 22 was be VBD cord-302953-gr2kk9w4 262 23 lower low JJR cord-302953-gr2kk9w4 262 24 in in IN cord-302953-gr2kk9w4 262 25 WT WT NNP cord-302953-gr2kk9w4 262 26 mice mouse NNS cord-302953-gr2kk9w4 262 27 than than IN cord-302953-gr2kk9w4 262 28 mice mouse NNS cord-302953-gr2kk9w4 262 29 with with IN cord-302953-gr2kk9w4 262 30 impaired impaired JJ cord-302953-gr2kk9w4 262 31 IFN IFN NNP cord-302953-gr2kk9w4 262 32 - - HYPH cord-302953-gr2kk9w4 262 33 γ γ NNP cord-302953-gr2kk9w4 262 34 signaling signaling NN cord-302953-gr2kk9w4 262 35 . . . cord-302953-gr2kk9w4 263 1 These these DT cord-302953-gr2kk9w4 263 2 findings finding NNS cord-302953-gr2kk9w4 263 3 indicate indicate VBP cord-302953-gr2kk9w4 263 4 that that IN cord-302953-gr2kk9w4 263 5 IFN IFN NNP cord-302953-gr2kk9w4 263 6 - - HYPH cord-302953-gr2kk9w4 263 7 γ γ NNP cord-302953-gr2kk9w4 263 8 signaling signal VBG cord-302953-gr2kk9w4 263 9 not not RB cord-302953-gr2kk9w4 263 10 only only RB cord-302953-gr2kk9w4 263 11 inhibits inhibit VBZ cord-302953-gr2kk9w4 263 12 infiltration infiltration NN cord-302953-gr2kk9w4 263 13 of of IN cord-302953-gr2kk9w4 263 14 CD8 CD8 NNP cord-302953-gr2kk9w4 263 15 + + CC cord-302953-gr2kk9w4 263 16 T T NNP cord-302953-gr2kk9w4 263 17 cells cell NNS cord-302953-gr2kk9w4 263 18 into into IN cord-302953-gr2kk9w4 263 19 the the DT cord-302953-gr2kk9w4 263 20 CNS CNS NNP cord-302953-gr2kk9w4 263 21 , , , cord-302953-gr2kk9w4 263 22 but but CC cord-302953-gr2kk9w4 263 23 also also RB cord-302953-gr2kk9w4 263 24 inhibits inhibit VBZ cord-302953-gr2kk9w4 263 25 CD8 CD8 NNP cord-302953-gr2kk9w4 263 26 + + CC cord-302953-gr2kk9w4 263 27 T T NNP cord-302953-gr2kk9w4 263 28 cell cell NN cord-302953-gr2kk9w4 263 29 synthesis synthesis NN cord-302953-gr2kk9w4 263 30 of of IN cord-302953-gr2kk9w4 263 31 granzyme granzyme NNP cord-302953-gr2kk9w4 263 32 B. B. NNP cord-302953-gr2kk9w4 263 33 3.10 3.10 CD cord-302953-gr2kk9w4 263 34 . . . cord-302953-gr2kk9w4 264 1 Effect effect NN cord-302953-gr2kk9w4 264 2 of of IN cord-302953-gr2kk9w4 264 3 IFN IFN NNP cord-302953-gr2kk9w4 264 4 - - HYPH cord-302953-gr2kk9w4 264 5 γ γ NNP cord-302953-gr2kk9w4 264 6 Signaling signal VBG cord-302953-gr2kk9w4 264 7 on on IN cord-302953-gr2kk9w4 264 8 CD8 CD8 NNP cord-302953-gr2kk9w4 264 9 + + CC cord-302953-gr2kk9w4 264 10 T T NNP cord-302953-gr2kk9w4 264 11 Cell Cell NNP cord-302953-gr2kk9w4 264 12 and and CC cord-302953-gr2kk9w4 264 13 NK NK NNP cord-302953-gr2kk9w4 264 14 Cell Cell NNP cord-302953-gr2kk9w4 264 15 Degranulation Degranulation NNP cord-302953-gr2kk9w4 264 16 and and CC cord-302953-gr2kk9w4 264 17 Cytotoxic Cytotoxic NNP cord-302953-gr2kk9w4 264 18 Function Function NNP cord-302953-gr2kk9w4 264 19 during during IN cord-302953-gr2kk9w4 264 20 SINV SINV NNP cord-302953-gr2kk9w4 264 21 Infection Infection NNP cord-302953-gr2kk9w4 264 22 CD8 CD8 NNP cord-302953-gr2kk9w4 264 23 + + CC cord-302953-gr2kk9w4 264 24 T T NNP cord-302953-gr2kk9w4 264 25 cells cell NNS cord-302953-gr2kk9w4 264 26 and and CC cord-302953-gr2kk9w4 264 27 NK NK NNP cord-302953-gr2kk9w4 264 28 cells cell NNS cord-302953-gr2kk9w4 264 29 primarily primarily RB cord-302953-gr2kk9w4 264 30 exert exert VBP cord-302953-gr2kk9w4 264 31 their -PRON- PRP$ cord-302953-gr2kk9w4 264 32 cytolytic cytolytic JJ cord-302953-gr2kk9w4 264 33 effects effect NNS cord-302953-gr2kk9w4 264 34 through through IN cord-302953-gr2kk9w4 264 35 secretion secretion NN cord-302953-gr2kk9w4 264 36 of of IN cord-302953-gr2kk9w4 264 37 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 264 38 granzymes granzyme NNS cord-302953-gr2kk9w4 264 39 that that WDT cord-302953-gr2kk9w4 264 40 kill kill VBP cord-302953-gr2kk9w4 264 41 target target NN cord-302953-gr2kk9w4 264 42 cells cell NNS cord-302953-gr2kk9w4 264 43 [ [ -LRB- cord-302953-gr2kk9w4 264 44 34 34 CD cord-302953-gr2kk9w4 264 45 ] ] -RRB- cord-302953-gr2kk9w4 264 46 . . . cord-302953-gr2kk9w4 265 1 Because because IN cord-302953-gr2kk9w4 265 2 infiltration infiltration NN cord-302953-gr2kk9w4 265 3 of of IN cord-302953-gr2kk9w4 265 4 CD8 CD8 NNP cord-302953-gr2kk9w4 265 5 + + CC cord-302953-gr2kk9w4 265 6 T T NNP cord-302953-gr2kk9w4 265 7 cells cell NNS cord-302953-gr2kk9w4 265 8 and and CC cord-302953-gr2kk9w4 265 9 NK NK NNP cord-302953-gr2kk9w4 265 10 cells cell NNS cord-302953-gr2kk9w4 265 11 into into IN cord-302953-gr2kk9w4 265 12 the the DT cord-302953-gr2kk9w4 265 13 brain brain NN cord-302953-gr2kk9w4 265 14 were be VBD cord-302953-gr2kk9w4 265 15 differentially differentially RB cord-302953-gr2kk9w4 265 16 regulated regulate VBN cord-302953-gr2kk9w4 265 17 by by IN cord-302953-gr2kk9w4 265 18 IFN IFN NNP cord-302953-gr2kk9w4 265 19 - - HYPH cord-302953-gr2kk9w4 265 20 γ γ NNP cord-302953-gr2kk9w4 265 21 signaling signaling NN cord-302953-gr2kk9w4 265 22 , , , cord-302953-gr2kk9w4 265 23 the the DT cord-302953-gr2kk9w4 265 24 extent extent NN cord-302953-gr2kk9w4 265 25 of of IN cord-302953-gr2kk9w4 265 26 degranulation degranulation NN cord-302953-gr2kk9w4 265 27 , , , cord-302953-gr2kk9w4 265 28 as as IN cord-302953-gr2kk9w4 265 29 identified identify VBN cord-302953-gr2kk9w4 265 30 by by IN cord-302953-gr2kk9w4 265 31 CD107a CD107a NNP cord-302953-gr2kk9w4 265 32 expression expression NN cord-302953-gr2kk9w4 265 33 [ [ -LRB- cord-302953-gr2kk9w4 265 34 35 35 CD cord-302953-gr2kk9w4 265 35 ] ] -RRB- cord-302953-gr2kk9w4 265 36 , , , cord-302953-gr2kk9w4 265 37 and and CC cord-302953-gr2kk9w4 265 38 granzyme granzyme NNS cord-302953-gr2kk9w4 265 39 production production NN cord-302953-gr2kk9w4 265 40 were be VBD cord-302953-gr2kk9w4 265 41 examined examine VBN cord-302953-gr2kk9w4 265 42 in in IN cord-302953-gr2kk9w4 265 43 cells cell NNS cord-302953-gr2kk9w4 265 44 from from IN cord-302953-gr2kk9w4 265 45 the the DT cord-302953-gr2kk9w4 265 46 CLNs cln NNS cord-302953-gr2kk9w4 265 47 and and CC cord-302953-gr2kk9w4 265 48 brains brain NNS cord-302953-gr2kk9w4 265 49 of of IN cord-302953-gr2kk9w4 265 50 WT WT NNP cord-302953-gr2kk9w4 265 51 , , , cord-302953-gr2kk9w4 265 52 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 265 53 −/− −/− NNP cord-302953-gr2kk9w4 265 54 , , , cord-302953-gr2kk9w4 265 55 and and CC cord-302953-gr2kk9w4 265 56 Ifng Ifng NNP cord-302953-gr2kk9w4 265 57 −/− −/− NNP cord-302953-gr2kk9w4 265 58 mice mouse NNS cord-302953-gr2kk9w4 265 59 at at IN cord-302953-gr2kk9w4 265 60 7 7 CD cord-302953-gr2kk9w4 265 61 DPI DPI NNP cord-302953-gr2kk9w4 265 62 . . . cord-302953-gr2kk9w4 266 1 In in IN cord-302953-gr2kk9w4 266 2 CLNs cln NNS cord-302953-gr2kk9w4 266 3 , , , cord-302953-gr2kk9w4 266 4 CD107a CD107a NNP cord-302953-gr2kk9w4 266 5 expression expression NN cord-302953-gr2kk9w4 266 6 by by IN cord-302953-gr2kk9w4 266 7 CD8 CD8 NNP cord-302953-gr2kk9w4 267 1 + + CC cord-302953-gr2kk9w4 268 1 T T NNP cord-302953-gr2kk9w4 268 2 cells cell NNS cord-302953-gr2kk9w4 268 3 was be VBD cord-302953-gr2kk9w4 268 4 minimally minimally RB cord-302953-gr2kk9w4 268 5 affected affect VBN cord-302953-gr2kk9w4 268 6 by by IN cord-302953-gr2kk9w4 268 7 IFN IFN NNP cord-302953-gr2kk9w4 268 8 - - HYPH cord-302953-gr2kk9w4 268 9 γ γ NNP cord-302953-gr2kk9w4 268 10 signaling signaling NN cord-302953-gr2kk9w4 268 11 ( ( -LRB- cord-302953-gr2kk9w4 268 12 Figure figure NN cord-302953-gr2kk9w4 268 13 10A 10a CD cord-302953-gr2kk9w4 268 14 ) ) -RRB- cord-302953-gr2kk9w4 268 15 . . . cord-302953-gr2kk9w4 269 1 In in IN cord-302953-gr2kk9w4 269 2 brain brain NN cord-302953-gr2kk9w4 269 3 , , , cord-302953-gr2kk9w4 269 4 the the DT cord-302953-gr2kk9w4 269 5 percentage percentage NN cord-302953-gr2kk9w4 269 6 of of IN cord-302953-gr2kk9w4 269 7 CD8 CD8 NNP cord-302953-gr2kk9w4 269 8 + + CC cord-302953-gr2kk9w4 269 9 T T NNP cord-302953-gr2kk9w4 269 10 cells cell NNS cord-302953-gr2kk9w4 269 11 expressing express VBG cord-302953-gr2kk9w4 269 12 CD107a CD107a NNP cord-302953-gr2kk9w4 269 13 was be VBD cord-302953-gr2kk9w4 269 14 higher high JJR cord-302953-gr2kk9w4 269 15 in in IN cord-302953-gr2kk9w4 269 16 Ifng Ifng NNP cord-302953-gr2kk9w4 269 17 −/− −/− NNP cord-302953-gr2kk9w4 269 18 mice mouse NNS cord-302953-gr2kk9w4 269 19 than than IN cord-302953-gr2kk9w4 269 20 WT wt NN cord-302953-gr2kk9w4 269 21 mice mouse NNS cord-302953-gr2kk9w4 269 22 , , , cord-302953-gr2kk9w4 269 23 but but CC cord-302953-gr2kk9w4 269 24 absolute absolute JJ cord-302953-gr2kk9w4 269 25 numbers number NNS cord-302953-gr2kk9w4 269 26 were be VBD cord-302953-gr2kk9w4 269 27 comparable comparable JJ cord-302953-gr2kk9w4 269 28 ( ( -LRB- cord-302953-gr2kk9w4 269 29 Figure figure NN cord-302953-gr2kk9w4 269 30 10C 10c CD cord-302953-gr2kk9w4 269 31 ) ) -RRB- cord-302953-gr2kk9w4 269 32 . . . cord-302953-gr2kk9w4 270 1 In in IN cord-302953-gr2kk9w4 270 2 contrast contrast NN cord-302953-gr2kk9w4 270 3 , , , cord-302953-gr2kk9w4 270 4 WT WT NNP cord-302953-gr2kk9w4 270 5 mice mouse NNS cord-302953-gr2kk9w4 270 6 had have VBD cord-302953-gr2kk9w4 270 7 more more RBR cord-302953-gr2kk9w4 270 8 degranulated degranulated JJ cord-302953-gr2kk9w4 270 9 NK NK NNP cord-302953-gr2kk9w4 270 10 cells cell NNS cord-302953-gr2kk9w4 270 11 in in IN cord-302953-gr2kk9w4 270 12 the the DT cord-302953-gr2kk9w4 270 13 CLNs cln NNS cord-302953-gr2kk9w4 270 14 ( ( -LRB- cord-302953-gr2kk9w4 270 15 Figure figure NN cord-302953-gr2kk9w4 270 16 10B 10b NN cord-302953-gr2kk9w4 270 17 ) ) -RRB- cord-302953-gr2kk9w4 270 18 and and CC cord-302953-gr2kk9w4 270 19 the the DT cord-302953-gr2kk9w4 270 20 brain brain NN cord-302953-gr2kk9w4 270 21 ( ( -LRB- cord-302953-gr2kk9w4 270 22 Figure figure NN cord-302953-gr2kk9w4 270 23 10D 10d CD cord-302953-gr2kk9w4 270 24 ) ) -RRB- cord-302953-gr2kk9w4 270 25 than than IN cord-302953-gr2kk9w4 270 26 either either CC cord-302953-gr2kk9w4 270 27 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 271 1 −/− −/− NNP cord-302953-gr2kk9w4 271 2 or or CC cord-302953-gr2kk9w4 271 3 Ifng Ifng NNP cord-302953-gr2kk9w4 271 4 −/− −/− NNP cord-302953-gr2kk9w4 271 5 mice mouse NNS cord-302953-gr2kk9w4 271 6 . . . cord-302953-gr2kk9w4 272 1 Therefore therefore RB cord-302953-gr2kk9w4 272 2 , , , cord-302953-gr2kk9w4 272 3 IFN IFN NNP cord-302953-gr2kk9w4 272 4 - - HYPH cord-302953-gr2kk9w4 272 5 γ γ NNP cord-302953-gr2kk9w4 272 6 signaling signaling NN cord-302953-gr2kk9w4 272 7 affected affect VBD cord-302953-gr2kk9w4 272 8 the the DT cord-302953-gr2kk9w4 272 9 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 272 10 function function NN cord-302953-gr2kk9w4 272 11 of of IN cord-302953-gr2kk9w4 272 12 local local JJ cord-302953-gr2kk9w4 272 13 CNS CNS NNP cord-302953-gr2kk9w4 272 14 NK NK NNP cord-302953-gr2kk9w4 272 15 cells cell NNS cord-302953-gr2kk9w4 272 16 and and CC cord-302953-gr2kk9w4 272 17 CD8 CD8 NNP cord-302953-gr2kk9w4 272 18 + + CC cord-302953-gr2kk9w4 272 19 T T NNP cord-302953-gr2kk9w4 272 20 cells cell NNS cord-302953-gr2kk9w4 272 21 during during IN cord-302953-gr2kk9w4 272 22 SINV SINV NNP cord-302953-gr2kk9w4 272 23 infection infection NN cord-302953-gr2kk9w4 272 24 , , , cord-302953-gr2kk9w4 272 25 but but CC cord-302953-gr2kk9w4 272 26 in in IN cord-302953-gr2kk9w4 272 27 opposite opposite JJ cord-302953-gr2kk9w4 272 28 directions direction NNS cord-302953-gr2kk9w4 272 29 . . . cord-302953-gr2kk9w4 272 30 _SP cord-302953-gr2kk9w4 273 1 Because because IN cord-302953-gr2kk9w4 273 2 long long JJ cord-302953-gr2kk9w4 273 3 - - HYPH cord-302953-gr2kk9w4 273 4 term term NN cord-302953-gr2kk9w4 273 5 control control NN cord-302953-gr2kk9w4 273 6 of of IN cord-302953-gr2kk9w4 273 7 viral viral JJ cord-302953-gr2kk9w4 273 8 RNA RNA NNP cord-302953-gr2kk9w4 273 9 is be VBZ cord-302953-gr2kk9w4 273 10 likely likely RB cord-302953-gr2kk9w4 273 11 required require VBN cord-302953-gr2kk9w4 273 12 to to TO cord-302953-gr2kk9w4 273 13 prevent prevent VB cord-302953-gr2kk9w4 273 14 reactivation reactivation NN cord-302953-gr2kk9w4 273 15 of of IN cord-302953-gr2kk9w4 273 16 virus virus NN cord-302953-gr2kk9w4 273 17 production production NN cord-302953-gr2kk9w4 273 18 and and CC cord-302953-gr2kk9w4 273 19 relapse relapse NN cord-302953-gr2kk9w4 273 20 of of IN cord-302953-gr2kk9w4 273 21 clinical clinical JJ cord-302953-gr2kk9w4 273 22 disease disease NN cord-302953-gr2kk9w4 273 23 , , , cord-302953-gr2kk9w4 273 24 immune immune JJ cord-302953-gr2kk9w4 273 25 cells cell NNS cord-302953-gr2kk9w4 273 26 remain remain VBP cord-302953-gr2kk9w4 273 27 in in IN cord-302953-gr2kk9w4 273 28 the the DT cord-302953-gr2kk9w4 273 29 CNS CNS NNP cord-302953-gr2kk9w4 273 30 long long JJ cord-302953-gr2kk9w4 273 31 term term NN cord-302953-gr2kk9w4 273 32 after after IN cord-302953-gr2kk9w4 273 33 SINV SINV NNP cord-302953-gr2kk9w4 273 34 infection infection NN cord-302953-gr2kk9w4 273 35 [ [ -LRB- cord-302953-gr2kk9w4 273 36 5 5 CD cord-302953-gr2kk9w4 273 37 ] ] -RRB- cord-302953-gr2kk9w4 273 38 . . . cord-302953-gr2kk9w4 274 1 Tissue tissue NN cord-302953-gr2kk9w4 274 2 - - HYPH cord-302953-gr2kk9w4 274 3 resident resident NN cord-302953-gr2kk9w4 274 4 memory memory NN cord-302953-gr2kk9w4 274 5 ( ( -LRB- cord-302953-gr2kk9w4 274 6 TRM TRM NNP cord-302953-gr2kk9w4 274 7 ) ) -RRB- cord-302953-gr2kk9w4 274 8 cells cell NNS cord-302953-gr2kk9w4 274 9 are be VBP cord-302953-gr2kk9w4 274 10 a a DT cord-302953-gr2kk9w4 274 11 subset subset NN cord-302953-gr2kk9w4 274 12 of of IN cord-302953-gr2kk9w4 274 13 memory memory NN cord-302953-gr2kk9w4 274 14 T t NN cord-302953-gr2kk9w4 274 15 cells cell NNS cord-302953-gr2kk9w4 274 16 that that WDT cord-302953-gr2kk9w4 274 17 do do VBP cord-302953-gr2kk9w4 274 18 not not RB cord-302953-gr2kk9w4 274 19 circulate circulate VB cord-302953-gr2kk9w4 274 20 , , , cord-302953-gr2kk9w4 274 21 but but CC cord-302953-gr2kk9w4 274 22 instead instead RB cord-302953-gr2kk9w4 274 23 permanently permanently RB cord-302953-gr2kk9w4 274 24 remain remain VBP cord-302953-gr2kk9w4 274 25 at at IN cord-302953-gr2kk9w4 274 26 sites site NNS cord-302953-gr2kk9w4 274 27 of of IN cord-302953-gr2kk9w4 274 28 infection infection NN cord-302953-gr2kk9w4 274 29 [ [ -LRB- cord-302953-gr2kk9w4 274 30 37 37 CD cord-302953-gr2kk9w4 274 31 ] ] -RRB- cord-302953-gr2kk9w4 274 32 . . . cord-302953-gr2kk9w4 275 1 CD103 CD103 NNP cord-302953-gr2kk9w4 275 2 + + CC cord-302953-gr2kk9w4 276 1 TRM TRM NNP cord-302953-gr2kk9w4 276 2 cells cell NNS cord-302953-gr2kk9w4 276 3 were be VBD cord-302953-gr2kk9w4 276 4 assessed assess VBN cord-302953-gr2kk9w4 276 5 in in IN cord-302953-gr2kk9w4 276 6 CLNs cln NNS cord-302953-gr2kk9w4 276 7 and and CC cord-302953-gr2kk9w4 276 8 brains brain NNS cord-302953-gr2kk9w4 276 9 in in IN cord-302953-gr2kk9w4 276 10 WT WT NNP cord-302953-gr2kk9w4 276 11 , , , cord-302953-gr2kk9w4 276 12 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 276 13 −/− −/− NNP cord-302953-gr2kk9w4 276 14 , , , cord-302953-gr2kk9w4 276 15 and and CC cord-302953-gr2kk9w4 276 16 Ifng Ifng NNP cord-302953-gr2kk9w4 276 17 −/− −/− NNP cord-302953-gr2kk9w4 276 18 mice mouse NNS cord-302953-gr2kk9w4 276 19 at at IN cord-302953-gr2kk9w4 276 20 7 7 CD cord-302953-gr2kk9w4 276 21 , , , cord-302953-gr2kk9w4 276 22 14 14 CD cord-302953-gr2kk9w4 276 23 , , , cord-302953-gr2kk9w4 276 24 and and CC cord-302953-gr2kk9w4 276 25 28 28 CD cord-302953-gr2kk9w4 276 26 DPI DPI NNP cord-302953-gr2kk9w4 276 27 to to TO cord-302953-gr2kk9w4 276 28 determine determine VB cord-302953-gr2kk9w4 276 29 a a DT cord-302953-gr2kk9w4 276 30 role role NN cord-302953-gr2kk9w4 276 31 for for IN cord-302953-gr2kk9w4 276 32 IFN IFN NNP cord-302953-gr2kk9w4 276 33 - - HYPH cord-302953-gr2kk9w4 276 34 γ γ NNP cord-302953-gr2kk9w4 276 35 in in IN cord-302953-gr2kk9w4 276 36 their -PRON- PRP$ cord-302953-gr2kk9w4 276 37 development development NN cord-302953-gr2kk9w4 276 38 , , , cord-302953-gr2kk9w4 276 39 maintenance maintenance NN cord-302953-gr2kk9w4 276 40 , , , cord-302953-gr2kk9w4 276 41 and and CC cord-302953-gr2kk9w4 276 42 survival survival NN cord-302953-gr2kk9w4 276 43 ( ( -LRB- cord-302953-gr2kk9w4 276 44 Figure figure NN cord-302953-gr2kk9w4 276 45 11A 11a NN cord-302953-gr2kk9w4 276 46 ) ) -RRB- cord-302953-gr2kk9w4 276 47 . . . cord-302953-gr2kk9w4 277 1 Very very RB cord-302953-gr2kk9w4 277 2 few few JJ cord-302953-gr2kk9w4 277 3 CD4 CD4 NNP cord-302953-gr2kk9w4 277 4 + + CC cord-302953-gr2kk9w4 277 5 or or CC cord-302953-gr2kk9w4 277 6 CD8 CD8 NNP cord-302953-gr2kk9w4 277 7 + + SYM cord-302953-gr2kk9w4 277 8 TRM TRM NNP cord-302953-gr2kk9w4 277 9 cells cell NNS cord-302953-gr2kk9w4 277 10 were be VBD cord-302953-gr2kk9w4 277 11 present present JJ cord-302953-gr2kk9w4 277 12 in in IN cord-302953-gr2kk9w4 277 13 CLNs cln NNS cord-302953-gr2kk9w4 277 14 of of IN cord-302953-gr2kk9w4 277 15 SINV SINV NNP cord-302953-gr2kk9w4 277 16 - - HYPH cord-302953-gr2kk9w4 277 17 infected infect VBN cord-302953-gr2kk9w4 277 18 mice mouse NNS cord-302953-gr2kk9w4 277 19 at at IN cord-302953-gr2kk9w4 277 20 any any DT cord-302953-gr2kk9w4 277 21 time time NN cord-302953-gr2kk9w4 277 22 after after IN cord-302953-gr2kk9w4 277 23 infection infection NN cord-302953-gr2kk9w4 277 24 ( ( -LRB- cord-302953-gr2kk9w4 277 25 Figure figure NN cord-302953-gr2kk9w4 277 26 11B 11b CD cord-302953-gr2kk9w4 277 27 ) ) -RRB- cord-302953-gr2kk9w4 277 28 . . . cord-302953-gr2kk9w4 278 1 Higher high JJR cord-302953-gr2kk9w4 278 2 percentages percentage NNS cord-302953-gr2kk9w4 278 3 of of IN cord-302953-gr2kk9w4 278 4 CD4 CD4 NNP cord-302953-gr2kk9w4 278 5 + + CC cord-302953-gr2kk9w4 278 6 T T NNP cord-302953-gr2kk9w4 278 7 cells cell NNS cord-302953-gr2kk9w4 278 8 in in IN cord-302953-gr2kk9w4 278 9 the the DT cord-302953-gr2kk9w4 278 10 brain brain NN cord-302953-gr2kk9w4 278 11 were be VBD cord-302953-gr2kk9w4 278 12 TRM TRM NNP cord-302953-gr2kk9w4 278 13 cells cell NNS cord-302953-gr2kk9w4 278 14 , , , cord-302953-gr2kk9w4 278 15 but but CC cord-302953-gr2kk9w4 278 16 they -PRON- PRP cord-302953-gr2kk9w4 278 17 did do VBD cord-302953-gr2kk9w4 278 18 not not RB cord-302953-gr2kk9w4 278 19 change change VB cord-302953-gr2kk9w4 278 20 over over IN cord-302953-gr2kk9w4 278 21 time time NN cord-302953-gr2kk9w4 278 22 or or CC cord-302953-gr2kk9w4 278 23 differ differ VB cord-302953-gr2kk9w4 278 24 among among IN cord-302953-gr2kk9w4 278 25 mouse mouse NN cord-302953-gr2kk9w4 278 26 strains strain NNS cord-302953-gr2kk9w4 278 27 Granzymes Granzymes NNP cord-302953-gr2kk9w4 278 28 A A NNP cord-302953-gr2kk9w4 278 29 and and CC cord-302953-gr2kk9w4 278 30 B b NN cord-302953-gr2kk9w4 279 1 are be VBP cord-302953-gr2kk9w4 279 2 the the DT cord-302953-gr2kk9w4 279 3 primary primary JJ cord-302953-gr2kk9w4 279 4 granzymes granzyme NNS cord-302953-gr2kk9w4 279 5 involved involve VBN cord-302953-gr2kk9w4 279 6 in in IN cord-302953-gr2kk9w4 279 7 cytotoxicity cytotoxicity NN cord-302953-gr2kk9w4 279 8 of of IN cord-302953-gr2kk9w4 279 9 CD8 CD8 NNP cord-302953-gr2kk9w4 279 10 + + CC cord-302953-gr2kk9w4 279 11 T T NNP cord-302953-gr2kk9w4 279 12 cells cell NNS cord-302953-gr2kk9w4 279 13 and and CC cord-302953-gr2kk9w4 279 14 NK NK NNP cord-302953-gr2kk9w4 279 15 cells cell NNS cord-302953-gr2kk9w4 279 16 [ [ -LRB- cord-302953-gr2kk9w4 279 17 36 36 CD cord-302953-gr2kk9w4 279 18 ] ] -RRB- cord-302953-gr2kk9w4 280 1 , , , cord-302953-gr2kk9w4 280 2 so so RB cord-302953-gr2kk9w4 280 3 we -PRON- PRP cord-302953-gr2kk9w4 280 4 next next RB cord-302953-gr2kk9w4 280 5 identified identify VBD cord-302953-gr2kk9w4 280 6 the the DT cord-302953-gr2kk9w4 280 7 granzymes granzyme NNS cord-302953-gr2kk9w4 280 8 produced produce VBN cord-302953-gr2kk9w4 280 9 in in IN cord-302953-gr2kk9w4 280 10 the the DT cord-302953-gr2kk9w4 280 11 brain brain NN cord-302953-gr2kk9w4 280 12 at at IN cord-302953-gr2kk9w4 280 13 7 7 CD cord-302953-gr2kk9w4 280 14 DPI dpi NN cord-302953-gr2kk9w4 280 15 during during IN cord-302953-gr2kk9w4 280 16 SINV SINV NNP cord-302953-gr2kk9w4 280 17 infection infection NN cord-302953-gr2kk9w4 280 18 and and CC cord-302953-gr2kk9w4 280 19 the the DT cord-302953-gr2kk9w4 280 20 effect effect NN cord-302953-gr2kk9w4 280 21 of of IN cord-302953-gr2kk9w4 280 22 IFN IFN NNP cord-302953-gr2kk9w4 280 23 - - HYPH cord-302953-gr2kk9w4 280 24 γ γ NN cord-302953-gr2kk9w4 280 25 signaling signal VBG cord-302953-gr2kk9w4 280 26 using use VBG cord-302953-gr2kk9w4 280 27 Boolean boolean JJ cord-302953-gr2kk9w4 280 28 gating gating NN cord-302953-gr2kk9w4 280 29 ( ( -LRB- cord-302953-gr2kk9w4 280 30 Figure figure NN cord-302953-gr2kk9w4 280 31 10E 10e NN cord-302953-gr2kk9w4 280 32 , , , cord-302953-gr2kk9w4 280 33 F F NNP cord-302953-gr2kk9w4 280 34 ) ) -RRB- cord-302953-gr2kk9w4 280 35 . . . cord-302953-gr2kk9w4 281 1 Approximately approximately RB cord-302953-gr2kk9w4 281 2 35 35 CD cord-302953-gr2kk9w4 281 3 to to TO cord-302953-gr2kk9w4 281 4 40 40 CD cord-302953-gr2kk9w4 281 5 % % NN cord-302953-gr2kk9w4 281 6 of of IN cord-302953-gr2kk9w4 281 7 CD8 CD8 NNP cord-302953-gr2kk9w4 281 8 + + CC cord-302953-gr2kk9w4 281 9 T T NNP cord-302953-gr2kk9w4 281 10 cells cell NNS cord-302953-gr2kk9w4 281 11 and and CC cord-302953-gr2kk9w4 281 12 65 65 CD cord-302953-gr2kk9w4 281 13 to to TO cord-302953-gr2kk9w4 281 14 70 70 CD cord-302953-gr2kk9w4 281 15 % % NN cord-302953-gr2kk9w4 281 16 of of IN cord-302953-gr2kk9w4 281 17 NK NK NNP cord-302953-gr2kk9w4 281 18 cells cell NNS cord-302953-gr2kk9w4 281 19 in in IN cord-302953-gr2kk9w4 281 20 the the DT cord-302953-gr2kk9w4 281 21 brain brain NN cord-302953-gr2kk9w4 281 22 produced produce VBD cord-302953-gr2kk9w4 281 23 both both DT cord-302953-gr2kk9w4 281 24 granzyme granzyme NNPS cord-302953-gr2kk9w4 281 25 A A NNP cord-302953-gr2kk9w4 281 26 and and CC cord-302953-gr2kk9w4 281 27 B. B. NNP cord-302953-gr2kk9w4 282 1 However however RB cord-302953-gr2kk9w4 282 2 , , , cord-302953-gr2kk9w4 282 3 if if IN cord-302953-gr2kk9w4 282 4 producing produce VBG cord-302953-gr2kk9w4 282 5 only only RB cord-302953-gr2kk9w4 282 6 one one CD cord-302953-gr2kk9w4 282 7 granzyme granzyme NNS cord-302953-gr2kk9w4 282 8 , , , cord-302953-gr2kk9w4 282 9 CD8 CD8 NNP cord-302953-gr2kk9w4 282 10 + + CC cord-302953-gr2kk9w4 282 11 T T NNP cord-302953-gr2kk9w4 282 12 cells cell NNS cord-302953-gr2kk9w4 282 13 preferentially preferentially RB cord-302953-gr2kk9w4 282 14 produced produce VBD cord-302953-gr2kk9w4 282 15 granzyme granzyme NNS cord-302953-gr2kk9w4 282 16 B B NNP cord-302953-gr2kk9w4 282 17 , , , cord-302953-gr2kk9w4 282 18 while while IN cord-302953-gr2kk9w4 282 19 NK NK NNP cord-302953-gr2kk9w4 282 20 cells cell NNS cord-302953-gr2kk9w4 282 21 preferentially preferentially RB cord-302953-gr2kk9w4 282 22 produced produce VBD cord-302953-gr2kk9w4 282 23 granzyme granzyme NNS cord-302953-gr2kk9w4 282 24 A a DT cord-302953-gr2kk9w4 282 25 ( ( -LRB- cord-302953-gr2kk9w4 282 26 Figure figure NN cord-302953-gr2kk9w4 282 27 10F 10f NN cord-302953-gr2kk9w4 282 28 ) ) -RRB- cord-302953-gr2kk9w4 282 29 . . . cord-302953-gr2kk9w4 283 1 Additionally additionally RB cord-302953-gr2kk9w4 283 2 , , , cord-302953-gr2kk9w4 283 3 granzyme granzyme NNS cord-302953-gr2kk9w4 283 4 production production NN cord-302953-gr2kk9w4 283 5 was be VBD cord-302953-gr2kk9w4 283 6 lower low JJR cord-302953-gr2kk9w4 283 7 in in IN cord-302953-gr2kk9w4 283 8 CD8 CD8 NNP cord-302953-gr2kk9w4 283 9 + + CC cord-302953-gr2kk9w4 283 10 T T NNP cord-302953-gr2kk9w4 283 11 cells cell NNS cord-302953-gr2kk9w4 283 12 but but CC cord-302953-gr2kk9w4 283 13 higher high JJR cord-302953-gr2kk9w4 283 14 in in IN cord-302953-gr2kk9w4 283 15 NK NK NNP cord-302953-gr2kk9w4 283 16 cells cell NNS cord-302953-gr2kk9w4 283 17 of of IN cord-302953-gr2kk9w4 283 18 WT WT NNP cord-302953-gr2kk9w4 283 19 mice mouse NNS cord-302953-gr2kk9w4 283 20 compared compare VBN cord-302953-gr2kk9w4 283 21 to to IN cord-302953-gr2kk9w4 283 22 mice mouse NNS cord-302953-gr2kk9w4 283 23 with with IN cord-302953-gr2kk9w4 283 24 impaired impaired JJ cord-302953-gr2kk9w4 283 25 IFN IFN NNP cord-302953-gr2kk9w4 283 26 - - HYPH cord-302953-gr2kk9w4 283 27 γ γ NNP cord-302953-gr2kk9w4 283 28 signaling signaling NN cord-302953-gr2kk9w4 283 29 . . . cord-302953-gr2kk9w4 284 1 Taken take VBN cord-302953-gr2kk9w4 284 2 together together RB cord-302953-gr2kk9w4 284 3 , , , cord-302953-gr2kk9w4 284 4 these these DT cord-302953-gr2kk9w4 284 5 data datum NNS cord-302953-gr2kk9w4 284 6 suggest suggest VBP cord-302953-gr2kk9w4 284 7 that that IN cord-302953-gr2kk9w4 284 8 IFN IFN NNP cord-302953-gr2kk9w4 284 9 - - HYPH cord-302953-gr2kk9w4 284 10 γ γ NNP cord-302953-gr2kk9w4 284 11 promotes promote VBZ cord-302953-gr2kk9w4 284 12 NK NK NNP cord-302953-gr2kk9w4 284 13 cell cell NN cord-302953-gr2kk9w4 284 14 cytotoxicity cytotoxicity NN cord-302953-gr2kk9w4 284 15 but but CC cord-302953-gr2kk9w4 284 16 suppresses suppress VBZ cord-302953-gr2kk9w4 284 17 the the DT cord-302953-gr2kk9w4 284 18 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 284 19 potential potential NN cord-302953-gr2kk9w4 284 20 of of IN cord-302953-gr2kk9w4 284 21 CD8 CD8 NNP cord-302953-gr2kk9w4 284 22 + + CC cord-302953-gr2kk9w4 284 23 T T NNP cord-302953-gr2kk9w4 284 24 cells cell NNS cord-302953-gr2kk9w4 284 25 in in IN cord-302953-gr2kk9w4 284 26 the the DT cord-302953-gr2kk9w4 284 27 brain brain NN cord-302953-gr2kk9w4 284 28 during during IN cord-302953-gr2kk9w4 284 29 SINV SINV NNP cord-302953-gr2kk9w4 284 30 infection infection NN cord-302953-gr2kk9w4 284 31 . . . cord-302953-gr2kk9w4 285 1 Because because IN cord-302953-gr2kk9w4 285 2 long long JJ cord-302953-gr2kk9w4 285 3 - - HYPH cord-302953-gr2kk9w4 285 4 term term NN cord-302953-gr2kk9w4 285 5 control control NN cord-302953-gr2kk9w4 285 6 of of IN cord-302953-gr2kk9w4 285 7 viral viral JJ cord-302953-gr2kk9w4 285 8 RNA RNA NNP cord-302953-gr2kk9w4 285 9 is be VBZ cord-302953-gr2kk9w4 285 10 likely likely RB cord-302953-gr2kk9w4 285 11 required require VBN cord-302953-gr2kk9w4 285 12 to to TO cord-302953-gr2kk9w4 285 13 prevent prevent VB cord-302953-gr2kk9w4 285 14 reactivation reactivation NN cord-302953-gr2kk9w4 285 15 of of IN cord-302953-gr2kk9w4 285 16 virus virus NN cord-302953-gr2kk9w4 285 17 production production NN cord-302953-gr2kk9w4 285 18 and and CC cord-302953-gr2kk9w4 285 19 relapse relapse NN cord-302953-gr2kk9w4 285 20 of of IN cord-302953-gr2kk9w4 285 21 clinical clinical JJ cord-302953-gr2kk9w4 285 22 disease disease NN cord-302953-gr2kk9w4 285 23 , , , cord-302953-gr2kk9w4 285 24 immune immune JJ cord-302953-gr2kk9w4 285 25 cells cell NNS cord-302953-gr2kk9w4 285 26 remain remain VBP cord-302953-gr2kk9w4 285 27 in in IN cord-302953-gr2kk9w4 285 28 the the DT cord-302953-gr2kk9w4 285 29 CNS CNS NNP cord-302953-gr2kk9w4 285 30 long long JJ cord-302953-gr2kk9w4 285 31 term term NN cord-302953-gr2kk9w4 285 32 after after IN cord-302953-gr2kk9w4 285 33 SINV SINV NNP cord-302953-gr2kk9w4 285 34 infection infection NN cord-302953-gr2kk9w4 285 35 [ [ -LRB- cord-302953-gr2kk9w4 285 36 5 5 CD cord-302953-gr2kk9w4 285 37 ] ] -RRB- cord-302953-gr2kk9w4 285 38 . . . cord-302953-gr2kk9w4 286 1 Tissue tissue NN cord-302953-gr2kk9w4 286 2 - - HYPH cord-302953-gr2kk9w4 286 3 resident resident NN cord-302953-gr2kk9w4 286 4 memory memory NN cord-302953-gr2kk9w4 287 1 ( ( -LRB- cord-302953-gr2kk9w4 287 2 T T NNP cord-302953-gr2kk9w4 287 3 RM RM NNP cord-302953-gr2kk9w4 287 4 ) ) -RRB- cord-302953-gr2kk9w4 287 5 cells cell NNS cord-302953-gr2kk9w4 287 6 are be VBP cord-302953-gr2kk9w4 287 7 a a DT cord-302953-gr2kk9w4 287 8 subset subset NN cord-302953-gr2kk9w4 287 9 of of IN cord-302953-gr2kk9w4 287 10 memory memory NN cord-302953-gr2kk9w4 287 11 T t NN cord-302953-gr2kk9w4 287 12 cells cell NNS cord-302953-gr2kk9w4 287 13 that that WDT cord-302953-gr2kk9w4 287 14 do do VBP cord-302953-gr2kk9w4 287 15 not not RB cord-302953-gr2kk9w4 287 16 circulate circulate VB cord-302953-gr2kk9w4 287 17 , , , cord-302953-gr2kk9w4 287 18 but but CC cord-302953-gr2kk9w4 287 19 instead instead RB cord-302953-gr2kk9w4 287 20 permanently permanently RB cord-302953-gr2kk9w4 287 21 remain remain VBP cord-302953-gr2kk9w4 287 22 at at IN cord-302953-gr2kk9w4 287 23 sites site NNS cord-302953-gr2kk9w4 287 24 of of IN cord-302953-gr2kk9w4 287 25 infection infection NN cord-302953-gr2kk9w4 287 26 [ [ -LRB- cord-302953-gr2kk9w4 287 27 37 37 CD cord-302953-gr2kk9w4 287 28 ] ] -RRB- cord-302953-gr2kk9w4 287 29 . . . cord-302953-gr2kk9w4 288 1 CD103 CD103 NNP cord-302953-gr2kk9w4 289 1 + + CC cord-302953-gr2kk9w4 289 2 T T NNP cord-302953-gr2kk9w4 289 3 RM rm NN cord-302953-gr2kk9w4 289 4 cells cell NNS cord-302953-gr2kk9w4 289 5 were be VBD cord-302953-gr2kk9w4 289 6 assessed assess VBN cord-302953-gr2kk9w4 289 7 in in IN cord-302953-gr2kk9w4 289 8 CLNs cln NNS cord-302953-gr2kk9w4 289 9 and and CC cord-302953-gr2kk9w4 289 10 brains brain NNS cord-302953-gr2kk9w4 289 11 in in IN cord-302953-gr2kk9w4 289 12 WT WT NNP cord-302953-gr2kk9w4 289 13 , , , cord-302953-gr2kk9w4 289 14 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 289 15 −/− −/− NNP cord-302953-gr2kk9w4 289 16 , , , cord-302953-gr2kk9w4 289 17 and and CC cord-302953-gr2kk9w4 289 18 Ifng Ifng NNP cord-302953-gr2kk9w4 289 19 −/− −/− NNP cord-302953-gr2kk9w4 289 20 mice mouse NNS cord-302953-gr2kk9w4 289 21 at at IN cord-302953-gr2kk9w4 289 22 7 7 CD cord-302953-gr2kk9w4 289 23 , , , cord-302953-gr2kk9w4 289 24 14 14 CD cord-302953-gr2kk9w4 289 25 , , , cord-302953-gr2kk9w4 289 26 and and CC cord-302953-gr2kk9w4 289 27 28 28 CD cord-302953-gr2kk9w4 289 28 DPI DPI NNP cord-302953-gr2kk9w4 289 29 to to TO cord-302953-gr2kk9w4 289 30 determine determine VB cord-302953-gr2kk9w4 289 31 a a DT cord-302953-gr2kk9w4 289 32 role role NN cord-302953-gr2kk9w4 289 33 for for IN cord-302953-gr2kk9w4 289 34 IFN IFN NNP cord-302953-gr2kk9w4 289 35 - - HYPH cord-302953-gr2kk9w4 289 36 γ γ NNP cord-302953-gr2kk9w4 289 37 in in IN cord-302953-gr2kk9w4 289 38 their -PRON- PRP$ cord-302953-gr2kk9w4 289 39 development development NN cord-302953-gr2kk9w4 289 40 , , , cord-302953-gr2kk9w4 289 41 maintenance maintenance NN cord-302953-gr2kk9w4 289 42 , , , cord-302953-gr2kk9w4 289 43 and and CC cord-302953-gr2kk9w4 289 44 survival survival NN cord-302953-gr2kk9w4 289 45 ( ( -LRB- cord-302953-gr2kk9w4 289 46 Figure figure NN cord-302953-gr2kk9w4 289 47 11A 11a NN cord-302953-gr2kk9w4 289 48 ) ) -RRB- cord-302953-gr2kk9w4 289 49 . . . cord-302953-gr2kk9w4 290 1 Very very RB cord-302953-gr2kk9w4 290 2 few few JJ cord-302953-gr2kk9w4 290 3 CD4 CD4 NNP cord-302953-gr2kk9w4 290 4 + + CC cord-302953-gr2kk9w4 290 5 or or CC cord-302953-gr2kk9w4 290 6 CD8 CD8 NNP cord-302953-gr2kk9w4 290 7 + + CC cord-302953-gr2kk9w4 290 8 T T NNP cord-302953-gr2kk9w4 290 9 RM rm NN cord-302953-gr2kk9w4 290 10 cells cell NNS cord-302953-gr2kk9w4 290 11 were be VBD cord-302953-gr2kk9w4 290 12 present present JJ cord-302953-gr2kk9w4 290 13 in in IN cord-302953-gr2kk9w4 290 14 CLNs cln NNS cord-302953-gr2kk9w4 290 15 of of IN cord-302953-gr2kk9w4 290 16 SINV SINV NNP cord-302953-gr2kk9w4 290 17 - - HYPH cord-302953-gr2kk9w4 290 18 infected infect VBN cord-302953-gr2kk9w4 290 19 mice mouse NNS cord-302953-gr2kk9w4 290 20 at at IN cord-302953-gr2kk9w4 290 21 any any DT cord-302953-gr2kk9w4 290 22 time time NN cord-302953-gr2kk9w4 290 23 after after IN cord-302953-gr2kk9w4 290 24 infection infection NN cord-302953-gr2kk9w4 290 25 ( ( -LRB- cord-302953-gr2kk9w4 290 26 Figure figure NN cord-302953-gr2kk9w4 290 27 11B 11b CD cord-302953-gr2kk9w4 290 28 ) ) -RRB- cord-302953-gr2kk9w4 290 29 . . . cord-302953-gr2kk9w4 291 1 Higher high JJR cord-302953-gr2kk9w4 291 2 percentages percentage NNS cord-302953-gr2kk9w4 291 3 of of IN cord-302953-gr2kk9w4 291 4 CD4 CD4 NNP cord-302953-gr2kk9w4 291 5 + + CC cord-302953-gr2kk9w4 291 6 T T NNP cord-302953-gr2kk9w4 291 7 cells cell NNS cord-302953-gr2kk9w4 291 8 in in IN cord-302953-gr2kk9w4 291 9 the the DT cord-302953-gr2kk9w4 291 10 brain brain NN cord-302953-gr2kk9w4 291 11 were be VBD cord-302953-gr2kk9w4 291 12 T T NNP cord-302953-gr2kk9w4 291 13 RM rm NN cord-302953-gr2kk9w4 291 14 cells cell NNS cord-302953-gr2kk9w4 291 15 , , , cord-302953-gr2kk9w4 291 16 but but CC cord-302953-gr2kk9w4 291 17 they -PRON- PRP cord-302953-gr2kk9w4 291 18 did do VBD cord-302953-gr2kk9w4 291 19 not not RB cord-302953-gr2kk9w4 291 20 change change VB cord-302953-gr2kk9w4 291 21 over over IN cord-302953-gr2kk9w4 291 22 time time NN cord-302953-gr2kk9w4 291 23 or or CC cord-302953-gr2kk9w4 291 24 differ differ VB cord-302953-gr2kk9w4 291 25 among among IN cord-302953-gr2kk9w4 291 26 mouse mouse NN cord-302953-gr2kk9w4 291 27 strains strain NNS cord-302953-gr2kk9w4 291 28 ( ( -LRB- cord-302953-gr2kk9w4 291 29 Figure figure NN cord-302953-gr2kk9w4 291 30 11C 11c CD cord-302953-gr2kk9w4 291 31 , , , cord-302953-gr2kk9w4 291 32 left leave VBN cord-302953-gr2kk9w4 291 33 panel panel NN cord-302953-gr2kk9w4 291 34 ) ) -RRB- cord-302953-gr2kk9w4 291 35 . . . cord-302953-gr2kk9w4 292 1 However however RB cord-302953-gr2kk9w4 292 2 , , , cord-302953-gr2kk9w4 292 3 percentages percentage NNS cord-302953-gr2kk9w4 292 4 of of IN cord-302953-gr2kk9w4 292 5 CD8 CD8 NNP cord-302953-gr2kk9w4 292 6 + + CC cord-302953-gr2kk9w4 292 7 T T NNP cord-302953-gr2kk9w4 292 8 RM rm NN cord-302953-gr2kk9w4 292 9 cells cell NNS cord-302953-gr2kk9w4 292 10 in in IN cord-302953-gr2kk9w4 292 11 the the DT cord-302953-gr2kk9w4 292 12 brain brain NN cord-302953-gr2kk9w4 292 13 increased increase VBD cord-302953-gr2kk9w4 292 14 over over IN cord-302953-gr2kk9w4 292 15 time time NN cord-302953-gr2kk9w4 292 16 ( ( -LRB- cord-302953-gr2kk9w4 292 17 Figure figure NN cord-302953-gr2kk9w4 292 18 11C 11c CD cord-302953-gr2kk9w4 292 19 , , , cord-302953-gr2kk9w4 292 20 right right JJ cord-302953-gr2kk9w4 292 21 panel panel NN cord-302953-gr2kk9w4 292 22 ) ) -RRB- cord-302953-gr2kk9w4 292 23 and and CC cord-302953-gr2kk9w4 292 24 were be VBD cord-302953-gr2kk9w4 292 25 more more RBR cord-302953-gr2kk9w4 292 26 abundant abundant JJ cord-302953-gr2kk9w4 292 27 in in IN cord-302953-gr2kk9w4 292 28 the the DT cord-302953-gr2kk9w4 292 29 brains brain NNS cord-302953-gr2kk9w4 292 30 of of IN cord-302953-gr2kk9w4 292 31 WT WT NNP cord-302953-gr2kk9w4 292 32 mice mouse NNS cord-302953-gr2kk9w4 292 33 than than IN cord-302953-gr2kk9w4 292 34 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 292 35 −/− −/− NNP cord-302953-gr2kk9w4 292 36 mice mouse NNS cord-302953-gr2kk9w4 292 37 at at IN cord-302953-gr2kk9w4 292 38 28 28 CD cord-302953-gr2kk9w4 292 39 DPI DPI NNP cord-302953-gr2kk9w4 292 40 and and CC cord-302953-gr2kk9w4 292 41 Ifng Ifng NNP cord-302953-gr2kk9w4 292 42 −/− −/− NNP cord-302953-gr2kk9w4 292 43 mice mouse NNS cord-302953-gr2kk9w4 292 44 at at IN cord-302953-gr2kk9w4 292 45 14 14 CD cord-302953-gr2kk9w4 292 46 and and CC cord-302953-gr2kk9w4 292 47 28 28 CD cord-302953-gr2kk9w4 292 48 DPI DPI NNP cord-302953-gr2kk9w4 292 49 . . . cord-302953-gr2kk9w4 293 1 The the DT cord-302953-gr2kk9w4 293 2 results result NNS cord-302953-gr2kk9w4 293 3 suggest suggest VBP cord-302953-gr2kk9w4 293 4 that that IN cord-302953-gr2kk9w4 293 5 IFN IFN NNP cord-302953-gr2kk9w4 293 6 - - HYPH cord-302953-gr2kk9w4 293 7 γ γ NNP cord-302953-gr2kk9w4 293 8 signaling signaling NN cord-302953-gr2kk9w4 293 9 promotes promote VBZ cord-302953-gr2kk9w4 293 10 the the DT cord-302953-gr2kk9w4 293 11 development development NN cord-302953-gr2kk9w4 293 12 of of IN cord-302953-gr2kk9w4 293 13 CD8 CD8 NNP cord-302953-gr2kk9w4 293 14 + + CC cord-302953-gr2kk9w4 293 15 T T NNP cord-302953-gr2kk9w4 293 16 RM rm NN cord-302953-gr2kk9w4 293 17 cells cell NNS cord-302953-gr2kk9w4 293 18 in in IN cord-302953-gr2kk9w4 293 19 the the DT cord-302953-gr2kk9w4 293 20 brain brain NN cord-302953-gr2kk9w4 293 21 during during IN cord-302953-gr2kk9w4 293 22 SINV SINV NNP cord-302953-gr2kk9w4 293 23 infection infection NN cord-302953-gr2kk9w4 293 24 and and CC cord-302953-gr2kk9w4 293 25 affects affect VBZ cord-302953-gr2kk9w4 293 26 their -PRON- PRP$ cord-302953-gr2kk9w4 293 27 presence presence NN cord-302953-gr2kk9w4 293 28 following follow VBG cord-302953-gr2kk9w4 293 29 infectious infectious JJ cord-302953-gr2kk9w4 293 30 virus virus NN cord-302953-gr2kk9w4 293 31 clearance clearance NN cord-302953-gr2kk9w4 293 32 . . . cord-302953-gr2kk9w4 293 33 _SP cord-302953-gr2kk9w4 294 1 IFN IFN NNP cord-302953-gr2kk9w4 294 2 - - HYPH cord-302953-gr2kk9w4 294 3 γ γ NNP cord-302953-gr2kk9w4 294 4 is be VBZ cord-302953-gr2kk9w4 294 5 an an DT cord-302953-gr2kk9w4 294 6 important important JJ cord-302953-gr2kk9w4 294 7 determinant determinant NN cord-302953-gr2kk9w4 294 8 of of IN cord-302953-gr2kk9w4 294 9 the the DT cord-302953-gr2kk9w4 294 10 outcome outcome NN cord-302953-gr2kk9w4 294 11 of of IN cord-302953-gr2kk9w4 294 12 virus virus NN cord-302953-gr2kk9w4 294 13 infections infection NNS cord-302953-gr2kk9w4 294 14 of of IN cord-302953-gr2kk9w4 294 15 the the DT cord-302953-gr2kk9w4 294 16 CNS CNS NNP cord-302953-gr2kk9w4 294 17 , , , cord-302953-gr2kk9w4 294 18 with with IN cord-302953-gr2kk9w4 294 19 both both DT cord-302953-gr2kk9w4 294 20 induction induction NN cord-302953-gr2kk9w4 294 21 of of IN cord-302953-gr2kk9w4 294 22 antiviral antiviral JJ cord-302953-gr2kk9w4 294 23 genes gene NNS cord-302953-gr2kk9w4 294 24 and and CC cord-302953-gr2kk9w4 294 25 regulation regulation NN cord-302953-gr2kk9w4 294 26 of of IN cord-302953-gr2kk9w4 294 27 the the DT cord-302953-gr2kk9w4 294 28 immune immune JJ cord-302953-gr2kk9w4 294 29 response response NN cord-302953-gr2kk9w4 294 30 to to IN cord-302953-gr2kk9w4 294 31 infection infection NN cord-302953-gr2kk9w4 294 32 . . . cord-302953-gr2kk9w4 295 1 Previous previous JJ cord-302953-gr2kk9w4 295 2 studies study NNS cord-302953-gr2kk9w4 295 3 have have VBP cord-302953-gr2kk9w4 295 4 shown show VBN cord-302953-gr2kk9w4 295 5 that that IN cord-302953-gr2kk9w4 295 6 IFN IFN NNP cord-302953-gr2kk9w4 295 7 - - HYPH cord-302953-gr2kk9w4 295 8 γ γ NNP cord-302953-gr2kk9w4 295 9 facilitates facilitate VBZ cord-302953-gr2kk9w4 295 10 clearance clearance NN cord-302953-gr2kk9w4 295 11 of of IN cord-302953-gr2kk9w4 295 12 infectious infectious JJ cord-302953-gr2kk9w4 295 13 virus virus NN cord-302953-gr2kk9w4 295 14 from from IN cord-302953-gr2kk9w4 295 15 spinal spinal JJ cord-302953-gr2kk9w4 295 16 cord cord NN cord-302953-gr2kk9w4 295 17 neurons neuron NNS cord-302953-gr2kk9w4 295 18 during during IN cord-302953-gr2kk9w4 295 19 SINV SINV NNP cord-302953-gr2kk9w4 295 20 infection infection NN cord-302953-gr2kk9w4 295 21 [ [ -LRB- cord-302953-gr2kk9w4 295 22 7 7 CD cord-302953-gr2kk9w4 295 23 ] ] -RRB- cord-302953-gr2kk9w4 295 24 , , , cord-302953-gr2kk9w4 295 25 and and CC cord-302953-gr2kk9w4 295 26 in in IN cord-302953-gr2kk9w4 295 27 vitro vitro FW cord-302953-gr2kk9w4 295 28 , , , cord-302953-gr2kk9w4 295 29 IFN IFN NNP cord-302953-gr2kk9w4 295 30 - - HYPH cord-302953-gr2kk9w4 295 31 γ γ NN cord-302953-gr2kk9w4 295 32 treatment treatment NN cord-302953-gr2kk9w4 295 33 inhibits inhibit VBZ cord-302953-gr2kk9w4 295 34 replication replication NN cord-302953-gr2kk9w4 295 35 of of IN cord-302953-gr2kk9w4 295 36 SINV SINV NNP cord-302953-gr2kk9w4 295 37 in in IN cord-302953-gr2kk9w4 295 38 neurons neuron NNS cord-302953-gr2kk9w4 295 39 through through IN cord-302953-gr2kk9w4 295 40 the the DT cord-302953-gr2kk9w4 295 41 Jak Jak NNP cord-302953-gr2kk9w4 295 42 / / SYM cord-302953-gr2kk9w4 295 43 Stat Stat NNP cord-302953-gr2kk9w4 295 44 signaling signal VBG cord-302953-gr2kk9w4 295 45 pathway pathway NN cord-302953-gr2kk9w4 295 46 [ [ -LRB- cord-302953-gr2kk9w4 295 47 16 16 CD cord-302953-gr2kk9w4 295 48 , , , cord-302953-gr2kk9w4 295 49 38 38 CD cord-302953-gr2kk9w4 295 50 ] ] -RRB- cord-302953-gr2kk9w4 295 51 ; ; : cord-302953-gr2kk9w4 295 52 however however RB cord-302953-gr2kk9w4 295 53 , , , cord-302953-gr2kk9w4 295 54 the the DT cord-302953-gr2kk9w4 295 55 antiviral antiviral JJ cord-302953-gr2kk9w4 295 56 genes gene NNS cord-302953-gr2kk9w4 295 57 induced induce VBN cord-302953-gr2kk9w4 295 58 were be VBD cord-302953-gr2kk9w4 295 59 not not RB cord-302953-gr2kk9w4 295 60 identified identify VBN cord-302953-gr2kk9w4 295 61 . . . cord-302953-gr2kk9w4 296 1 The the DT cord-302953-gr2kk9w4 296 2 current current JJ cord-302953-gr2kk9w4 296 3 study study NN cord-302953-gr2kk9w4 296 4 showed show VBD cord-302953-gr2kk9w4 296 5 that that IN cord-302953-gr2kk9w4 296 6 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 296 7 for for IN cord-302953-gr2kk9w4 296 8 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 296 9 and and CC cord-302953-gr2kk9w4 296 10 Irgm1 irgm1 IN cord-302953-gr2kk9w4 296 11 GTPase GTPase NNP cord-302953-gr2kk9w4 296 12 proteins protein NNS cord-302953-gr2kk9w4 296 13 associated associate VBN cord-302953-gr2kk9w4 296 14 with with IN cord-302953-gr2kk9w4 296 15 autophagy autophagy NN cord-302953-gr2kk9w4 296 16 were be VBD cord-302953-gr2kk9w4 296 17 Figure figure NN cord-302953-gr2kk9w4 296 18 11 11 CD cord-302953-gr2kk9w4 296 19 . . . cord-302953-gr2kk9w4 297 1 Effect effect NN cord-302953-gr2kk9w4 297 2 of of IN cord-302953-gr2kk9w4 297 3 IFN IFN NNP cord-302953-gr2kk9w4 297 4 - - HYPH cord-302953-gr2kk9w4 297 5 γ γ NNP cord-302953-gr2kk9w4 297 6 signaling signal VBG cord-302953-gr2kk9w4 297 7 on on IN cord-302953-gr2kk9w4 297 8 T T NNP cord-302953-gr2kk9w4 297 9 RM rm NN cord-302953-gr2kk9w4 297 10 cell cell NN cord-302953-gr2kk9w4 297 11 populations population NNS cord-302953-gr2kk9w4 297 12 . . . cord-302953-gr2kk9w4 298 1 Flow flow NN cord-302953-gr2kk9w4 298 2 cytometry cytometry NN cord-302953-gr2kk9w4 298 3 was be VBD cord-302953-gr2kk9w4 298 4 used use VBN cord-302953-gr2kk9w4 298 5 to to TO cord-302953-gr2kk9w4 298 6 examine examine VB cord-302953-gr2kk9w4 298 7 T T NNP cord-302953-gr2kk9w4 298 8 RM rm NN cord-302953-gr2kk9w4 298 9 cell cell NN cord-302953-gr2kk9w4 298 10 populations population NNS cord-302953-gr2kk9w4 298 11 by by IN cord-302953-gr2kk9w4 298 12 gating gate VBG cord-302953-gr2kk9w4 298 13 , , , cord-302953-gr2kk9w4 298 14 denoted denote VBN cord-302953-gr2kk9w4 298 15 by by IN cord-302953-gr2kk9w4 298 16 blue blue JJ cord-302953-gr2kk9w4 298 17 frames frame NNS cord-302953-gr2kk9w4 298 18 , , , cord-302953-gr2kk9w4 298 19 around around RB cord-302953-gr2kk9w4 298 20 CD103 CD103 NNS cord-302953-gr2kk9w4 298 21 + + CC cord-302953-gr2kk9w4 298 22 cells cell NNS cord-302953-gr2kk9w4 298 23 ( ( -LRB- cord-302953-gr2kk9w4 298 24 A a NN cord-302953-gr2kk9w4 298 25 ) ) -RRB- cord-302953-gr2kk9w4 298 26 at at IN cord-302953-gr2kk9w4 298 27 7 7 CD cord-302953-gr2kk9w4 298 28 , , , cord-302953-gr2kk9w4 298 29 14 14 CD cord-302953-gr2kk9w4 298 30 , , , cord-302953-gr2kk9w4 298 31 and and CC cord-302953-gr2kk9w4 298 32 28 28 CD cord-302953-gr2kk9w4 298 33 DPI DPI NNP cord-302953-gr2kk9w4 298 34 in in IN cord-302953-gr2kk9w4 298 35 the the DT cord-302953-gr2kk9w4 298 36 CLNs cln NNS cord-302953-gr2kk9w4 298 37 ( ( -LRB- cord-302953-gr2kk9w4 298 38 B b NN cord-302953-gr2kk9w4 298 39 ) ) -RRB- cord-302953-gr2kk9w4 298 40 and and CC cord-302953-gr2kk9w4 298 41 brains brain NNS cord-302953-gr2kk9w4 298 42 ( ( -LRB- cord-302953-gr2kk9w4 298 43 C C NNP cord-302953-gr2kk9w4 298 44 ) ) -RRB- cord-302953-gr2kk9w4 298 45 of of IN cord-302953-gr2kk9w4 298 46 WT WT NNP cord-302953-gr2kk9w4 298 47 ( ( -LRB- cord-302953-gr2kk9w4 298 48 black black JJ cord-302953-gr2kk9w4 298 49 bars bar NNS cord-302953-gr2kk9w4 298 50 ) ) -RRB- cord-302953-gr2kk9w4 298 51 , , . cord-302953-gr2kk9w4 299 1 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 299 2 −/− −/− NNP cord-302953-gr2kk9w4 299 3 ( ( -LRB- cord-302953-gr2kk9w4 299 4 gray gray JJ cord-302953-gr2kk9w4 299 5 bars bar NNS cord-302953-gr2kk9w4 299 6 ) ) -RRB- cord-302953-gr2kk9w4 299 7 , , , cord-302953-gr2kk9w4 299 8 and and CC cord-302953-gr2kk9w4 299 9 Ifng Ifng NNP cord-302953-gr2kk9w4 299 10 −/− −/− NNP cord-302953-gr2kk9w4 299 11 ( ( -LRB- cord-302953-gr2kk9w4 299 12 white white JJ cord-302953-gr2kk9w4 299 13 bars bar NNS cord-302953-gr2kk9w4 299 14 ) ) -RRB- cord-302953-gr2kk9w4 299 15 mice mouse NNS cord-302953-gr2kk9w4 299 16 , , , cord-302953-gr2kk9w4 299 17 and and CC cord-302953-gr2kk9w4 299 18 results result NNS cord-302953-gr2kk9w4 299 19 are be VBP cord-302953-gr2kk9w4 299 20 presented present VBN cord-302953-gr2kk9w4 299 21 as as IN cord-302953-gr2kk9w4 299 22 a a DT cord-302953-gr2kk9w4 299 23 percentage percentage NN cord-302953-gr2kk9w4 299 24 of of IN cord-302953-gr2kk9w4 299 25 CD4 CD4 NNP cord-302953-gr2kk9w4 299 26 + + CC cord-302953-gr2kk9w4 299 27 ( ( -LRB- cord-302953-gr2kk9w4 299 28 left left JJ cord-302953-gr2kk9w4 299 29 graphs graph NNS cord-302953-gr2kk9w4 299 30 ) ) -RRB- cord-302953-gr2kk9w4 299 31 and and CC cord-302953-gr2kk9w4 299 32 CD8 CD8 NNP cord-302953-gr2kk9w4 299 33 + + CC cord-302953-gr2kk9w4 299 34 T T NNP cord-302953-gr2kk9w4 299 35 cells cell NNS cord-302953-gr2kk9w4 299 36 ( ( -LRB- cord-302953-gr2kk9w4 299 37 right right JJ cord-302953-gr2kk9w4 299 38 graphs graph NNS cord-302953-gr2kk9w4 299 39 ) ) -RRB- cord-302953-gr2kk9w4 299 40 ( ( -LRB- cord-302953-gr2kk9w4 299 41 n n NN cord-302953-gr2kk9w4 299 42 = = SYM cord-302953-gr2kk9w4 299 43 2 2 CD cord-302953-gr2kk9w4 299 44 - - SYM cord-302953-gr2kk9w4 299 45 7 7 CD cord-302953-gr2kk9w4 299 46 pooled pool VBN cord-302953-gr2kk9w4 299 47 mice mouse NNS cord-302953-gr2kk9w4 299 48 per per IN cord-302953-gr2kk9w4 299 49 strain strain NN cord-302953-gr2kk9w4 299 50 per per IN cord-302953-gr2kk9w4 299 51 time time NN cord-302953-gr2kk9w4 299 52 point point NN cord-302953-gr2kk9w4 299 53 from from IN cord-302953-gr2kk9w4 299 54 three three CD cord-302953-gr2kk9w4 299 55 to to TO cord-302953-gr2kk9w4 299 56 four four CD cord-302953-gr2kk9w4 299 57 independent independent JJ cord-302953-gr2kk9w4 299 58 experiments experiment NNS cord-302953-gr2kk9w4 299 59 ; ; : cord-302953-gr2kk9w4 299 60 data datum NNS cord-302953-gr2kk9w4 299 61 are be VBP cord-302953-gr2kk9w4 299 62 presented present VBN cord-302953-gr2kk9w4 299 63 as as IN cord-302953-gr2kk9w4 299 64 the the DT cord-302953-gr2kk9w4 299 65 mean mean JJ cord-302953-gr2kk9w4 299 66 ± ± NNP cord-302953-gr2kk9w4 299 67 SEM SEM NNP cord-302953-gr2kk9w4 299 68 ; ; : cord-302953-gr2kk9w4 299 69 * * NFP cord-302953-gr2kk9w4 299 70 p p NN cord-302953-gr2kk9w4 299 71 < < XX cord-302953-gr2kk9w4 299 72 0.05 0.05 CD cord-302953-gr2kk9w4 299 73 , , , cord-302953-gr2kk9w4 300 1 * * NFP cord-302953-gr2kk9w4 300 2 * * NFP cord-302953-gr2kk9w4 300 3 * * NFP cord-302953-gr2kk9w4 300 4 p p XX cord-302953-gr2kk9w4 300 5 < < XX cord-302953-gr2kk9w4 300 6 0.001 0.001 CD cord-302953-gr2kk9w4 300 7 by by IN cord-302953-gr2kk9w4 300 8 Tukey Tukey NNP cord-302953-gr2kk9w4 300 9 's 's POS cord-302953-gr2kk9w4 300 10 multiple multiple JJ cord-302953-gr2kk9w4 300 11 comparisons comparison NNS cord-302953-gr2kk9w4 300 12 test test VBP cord-302953-gr2kk9w4 300 13 ) ) -RRB- cord-302953-gr2kk9w4 300 14 . . . cord-302953-gr2kk9w4 301 1 IFN IFN NNP cord-302953-gr2kk9w4 301 2 - - HYPH cord-302953-gr2kk9w4 301 3 γ γ NNP cord-302953-gr2kk9w4 301 4 is be VBZ cord-302953-gr2kk9w4 301 5 an an DT cord-302953-gr2kk9w4 301 6 important important JJ cord-302953-gr2kk9w4 301 7 determinant determinant NN cord-302953-gr2kk9w4 301 8 of of IN cord-302953-gr2kk9w4 301 9 the the DT cord-302953-gr2kk9w4 301 10 outcome outcome NN cord-302953-gr2kk9w4 301 11 of of IN cord-302953-gr2kk9w4 301 12 virus virus NN cord-302953-gr2kk9w4 301 13 infections infection NNS cord-302953-gr2kk9w4 301 14 of of IN cord-302953-gr2kk9w4 301 15 the the DT cord-302953-gr2kk9w4 301 16 CNS CNS NNP cord-302953-gr2kk9w4 301 17 , , , cord-302953-gr2kk9w4 301 18 with with IN cord-302953-gr2kk9w4 301 19 both both DT cord-302953-gr2kk9w4 301 20 induction induction NN cord-302953-gr2kk9w4 301 21 of of IN cord-302953-gr2kk9w4 301 22 antiviral antiviral JJ cord-302953-gr2kk9w4 301 23 genes gene NNS cord-302953-gr2kk9w4 301 24 and and CC cord-302953-gr2kk9w4 301 25 regulation regulation NN cord-302953-gr2kk9w4 301 26 of of IN cord-302953-gr2kk9w4 301 27 the the DT cord-302953-gr2kk9w4 301 28 immune immune JJ cord-302953-gr2kk9w4 301 29 response response NN cord-302953-gr2kk9w4 301 30 to to IN cord-302953-gr2kk9w4 301 31 infection infection NN cord-302953-gr2kk9w4 301 32 . . . cord-302953-gr2kk9w4 302 1 Previous previous JJ cord-302953-gr2kk9w4 302 2 studies study NNS cord-302953-gr2kk9w4 302 3 have have VBP cord-302953-gr2kk9w4 302 4 shown show VBN cord-302953-gr2kk9w4 302 5 that that IN cord-302953-gr2kk9w4 302 6 IFN IFN NNP cord-302953-gr2kk9w4 302 7 - - HYPH cord-302953-gr2kk9w4 302 8 γ γ NNP cord-302953-gr2kk9w4 302 9 facilitates facilitate VBZ cord-302953-gr2kk9w4 302 10 clearance clearance NN cord-302953-gr2kk9w4 302 11 of of IN cord-302953-gr2kk9w4 302 12 infectious infectious JJ cord-302953-gr2kk9w4 302 13 virus virus NN cord-302953-gr2kk9w4 302 14 from from IN cord-302953-gr2kk9w4 302 15 spinal spinal JJ cord-302953-gr2kk9w4 302 16 cord cord NN cord-302953-gr2kk9w4 302 17 neurons neuron NNS cord-302953-gr2kk9w4 302 18 during during IN cord-302953-gr2kk9w4 302 19 SINV SINV NNP cord-302953-gr2kk9w4 302 20 infection infection NN cord-302953-gr2kk9w4 302 21 [ [ -LRB- cord-302953-gr2kk9w4 302 22 7 7 CD cord-302953-gr2kk9w4 302 23 ] ] -RRB- cord-302953-gr2kk9w4 302 24 , , , cord-302953-gr2kk9w4 302 25 and and CC cord-302953-gr2kk9w4 302 26 in in IN cord-302953-gr2kk9w4 302 27 vitro vitro FW cord-302953-gr2kk9w4 302 28 , , , cord-302953-gr2kk9w4 302 29 IFN IFN NNP cord-302953-gr2kk9w4 302 30 - - HYPH cord-302953-gr2kk9w4 302 31 γ γ NN cord-302953-gr2kk9w4 302 32 treatment treatment NN cord-302953-gr2kk9w4 302 33 inhibits inhibit VBZ cord-302953-gr2kk9w4 302 34 replication replication NN cord-302953-gr2kk9w4 302 35 of of IN cord-302953-gr2kk9w4 302 36 SINV SINV NNP cord-302953-gr2kk9w4 302 37 in in IN cord-302953-gr2kk9w4 302 38 neurons neuron NNS cord-302953-gr2kk9w4 302 39 through through IN cord-302953-gr2kk9w4 302 40 the the DT cord-302953-gr2kk9w4 302 41 Jak Jak NNP cord-302953-gr2kk9w4 302 42 / / SYM cord-302953-gr2kk9w4 302 43 Stat Stat NNP cord-302953-gr2kk9w4 302 44 signaling signal VBG cord-302953-gr2kk9w4 302 45 pathway pathway NN cord-302953-gr2kk9w4 302 46 [ [ -LRB- cord-302953-gr2kk9w4 302 47 16 16 CD cord-302953-gr2kk9w4 302 48 , , , cord-302953-gr2kk9w4 302 49 38 38 CD cord-302953-gr2kk9w4 302 50 ] ] -RRB- cord-302953-gr2kk9w4 302 51 ; ; : cord-302953-gr2kk9w4 302 52 however however RB cord-302953-gr2kk9w4 302 53 , , , cord-302953-gr2kk9w4 302 54 the the DT cord-302953-gr2kk9w4 302 55 antiviral antiviral JJ cord-302953-gr2kk9w4 302 56 genes gene NNS cord-302953-gr2kk9w4 302 57 induced induce VBN cord-302953-gr2kk9w4 302 58 were be VBD cord-302953-gr2kk9w4 302 59 not not RB cord-302953-gr2kk9w4 302 60 identified identify VBN cord-302953-gr2kk9w4 302 61 . . . cord-302953-gr2kk9w4 303 1 The the DT cord-302953-gr2kk9w4 303 2 current current JJ cord-302953-gr2kk9w4 303 3 study study NN cord-302953-gr2kk9w4 303 4 showed show VBD cord-302953-gr2kk9w4 303 5 that that IN cord-302953-gr2kk9w4 303 6 mRNAs mRNAs NNPS cord-302953-gr2kk9w4 303 7 for for IN cord-302953-gr2kk9w4 303 8 Gbp2 Gbp2 NNP cord-302953-gr2kk9w4 303 9 and and CC cord-302953-gr2kk9w4 303 10 Irgm1 irgm1 IN cord-302953-gr2kk9w4 303 11 GTPase GTPase NNP cord-302953-gr2kk9w4 303 12 proteins protein NNS cord-302953-gr2kk9w4 303 13 associated associate VBN cord-302953-gr2kk9w4 303 14 with with IN cord-302953-gr2kk9w4 303 15 autophagy autophagy NN cord-302953-gr2kk9w4 303 16 were be VBD cord-302953-gr2kk9w4 303 17 highly highly RB cord-302953-gr2kk9w4 303 18 induced induce VBN cord-302953-gr2kk9w4 303 19 by by IN cord-302953-gr2kk9w4 303 20 IFN IFN NNP cord-302953-gr2kk9w4 303 21 - - HYPH cord-302953-gr2kk9w4 303 22 γ γ NNP cord-302953-gr2kk9w4 303 23 signaling signal VBG cord-302953-gr2kk9w4 303 24 in in IN cord-302953-gr2kk9w4 303 25 SINV SINV NNP cord-302953-gr2kk9w4 303 26 - - HYPH cord-302953-gr2kk9w4 303 27 infected infect VBN cord-302953-gr2kk9w4 303 28 neurons neuron NNS cord-302953-gr2kk9w4 303 29 as as RB cord-302953-gr2kk9w4 303 30 well well RB cord-302953-gr2kk9w4 303 31 as as IN cord-302953-gr2kk9w4 303 32 in in IN cord-302953-gr2kk9w4 303 33 the the DT cord-302953-gr2kk9w4 303 34 CNS CNS NNP cord-302953-gr2kk9w4 303 35 of of IN cord-302953-gr2kk9w4 303 36 SINV SINV NNP cord-302953-gr2kk9w4 303 37 - - HYPH cord-302953-gr2kk9w4 303 38 infected infect VBN cord-302953-gr2kk9w4 303 39 mice mice NN cord-302953-gr2kk9w4 303 40 where where WRB cord-302953-gr2kk9w4 303 41 multiple multiple JJ cord-302953-gr2kk9w4 303 42 cells cell NNS cord-302953-gr2kk9w4 303 43 may may MD cord-302953-gr2kk9w4 303 44 be be VB cord-302953-gr2kk9w4 303 45 responding respond VBG cord-302953-gr2kk9w4 303 46 to to IN cord-302953-gr2kk9w4 303 47 secreted secrete VBN cord-302953-gr2kk9w4 303 48 IFN IFN NNP cord-302953-gr2kk9w4 303 49 - - HYPH cord-302953-gr2kk9w4 303 50 γ γ NNP cord-302953-gr2kk9w4 303 51 . . . cord-302953-gr2kk9w4 304 1 Autophagy Autophagy NNP cord-302953-gr2kk9w4 304 2 can can MD cord-302953-gr2kk9w4 304 3 decrease decrease VB cord-302953-gr2kk9w4 304 4 virus virus NN cord-302953-gr2kk9w4 304 5 replication replication NN cord-302953-gr2kk9w4 304 6 by by IN cord-302953-gr2kk9w4 304 7 destroying destroy VBG cord-302953-gr2kk9w4 304 8 virus virus NN cord-302953-gr2kk9w4 304 9 or or CC cord-302953-gr2kk9w4 304 10 viral viral JJ cord-302953-gr2kk9w4 304 11 replication replication NN cord-302953-gr2kk9w4 304 12 components component NNS cord-302953-gr2kk9w4 304 13 , , , cord-302953-gr2kk9w4 304 14 including include VBG cord-302953-gr2kk9w4 304 15 alphaviruses alphavirus NNS cord-302953-gr2kk9w4 304 16 , , , cord-302953-gr2kk9w4 304 17 or or CC cord-302953-gr2kk9w4 304 18 by by IN cord-302953-gr2kk9w4 304 19 delivering deliver VBG cord-302953-gr2kk9w4 304 20 them -PRON- PRP cord-302953-gr2kk9w4 304 21 to to IN cord-302953-gr2kk9w4 304 22 endosomes endosomes VB cord-302953-gr2kk9w4 304 23 for for IN cord-302953-gr2kk9w4 304 24 Toll toll NN cord-302953-gr2kk9w4 304 25 - - HYPH cord-302953-gr2kk9w4 304 26 like like JJ cord-302953-gr2kk9w4 304 27 receptor receptor NN cord-302953-gr2kk9w4 304 28 ( ( -LRB- cord-302953-gr2kk9w4 304 29 TLR TLR NNP cord-302953-gr2kk9w4 304 30 ) ) -RRB- cord-302953-gr2kk9w4 304 31 induction induction NN cord-302953-gr2kk9w4 304 32 of of IN cord-302953-gr2kk9w4 304 33 the the DT cord-302953-gr2kk9w4 304 34 innate innate JJ cord-302953-gr2kk9w4 304 35 immune immune JJ cord-302953-gr2kk9w4 304 36 response response NN cord-302953-gr2kk9w4 304 37 [ [ -LRB- cord-302953-gr2kk9w4 304 38 39 39 CD cord-302953-gr2kk9w4 304 39 ] ] -RRB- cord-302953-gr2kk9w4 305 1 [ [ -LRB- cord-302953-gr2kk9w4 305 2 40 40 CD cord-302953-gr2kk9w4 305 3 ] ] -RRB- cord-302953-gr2kk9w4 305 4 [ [ -LRB- cord-302953-gr2kk9w4 305 5 41 41 CD cord-302953-gr2kk9w4 305 6 ] ] -RRB- cord-302953-gr2kk9w4 305 7 . . . cord-302953-gr2kk9w4 306 1 RNA RNA NNP cord-302953-gr2kk9w4 306 2 viruses virus NNS cord-302953-gr2kk9w4 306 3 , , , cord-302953-gr2kk9w4 306 4 including include VBG cord-302953-gr2kk9w4 306 5 the the DT cord-302953-gr2kk9w4 306 6 alphavirus alphavirus NNP cord-302953-gr2kk9w4 306 7 chikungunya chikungunya NN cord-302953-gr2kk9w4 306 8 virus virus NN cord-302953-gr2kk9w4 306 9 ( ( -LRB- cord-302953-gr2kk9w4 306 10 CHIKV CHIKV NNP cord-302953-gr2kk9w4 306 11 ) ) -RRB- cord-302953-gr2kk9w4 306 12 , , , cord-302953-gr2kk9w4 306 13 target target VB cord-302953-gr2kk9w4 306 14 IRGM IRGM NNP cord-302953-gr2kk9w4 306 15 to to TO cord-302953-gr2kk9w4 306 16 promote promote VB cord-302953-gr2kk9w4 306 17 virus virus NN cord-302953-gr2kk9w4 306 18 replication replication NN cord-302953-gr2kk9w4 306 19 [ [ -LRB- cord-302953-gr2kk9w4 306 20 42 42 CD cord-302953-gr2kk9w4 306 21 , , , cord-302953-gr2kk9w4 306 22 43 43 CD cord-302953-gr2kk9w4 306 23 ] ] -RRB- cord-302953-gr2kk9w4 306 24 . . . cord-302953-gr2kk9w4 307 1 Another another DT cord-302953-gr2kk9w4 307 2 antiviral antiviral JJ cord-302953-gr2kk9w4 307 3 protein protein NN cord-302953-gr2kk9w4 307 4 system system NN cord-302953-gr2kk9w4 307 5 highly highly RB cord-302953-gr2kk9w4 307 6 induced induce VBN cord-302953-gr2kk9w4 307 7 by by IN cord-302953-gr2kk9w4 307 8 IFN IFN NNP cord-302953-gr2kk9w4 307 9 - - HYPH cord-302953-gr2kk9w4 307 10 γ γ NNP cord-302953-gr2kk9w4 307 11 signaling signal VBG cord-302953-gr2kk9w4 307 12 during during IN cord-302953-gr2kk9w4 307 13 SINV SINV NNP cord-302953-gr2kk9w4 307 14 infection infection NN cord-302953-gr2kk9w4 307 15 of of IN cord-302953-gr2kk9w4 307 16 neurons neuron NNS cord-302953-gr2kk9w4 307 17 was be VBD cord-302953-gr2kk9w4 307 18 the the DT cord-302953-gr2kk9w4 307 19 2 2 CD cord-302953-gr2kk9w4 307 20 -5 -5 CD cord-302953-gr2kk9w4 307 21 -oligoadenylate -oligoadenylate HYPH cord-302953-gr2kk9w4 307 22 synthetase synthetase NN cord-302953-gr2kk9w4 307 23 ( ( -LRB- cord-302953-gr2kk9w4 307 24 OAS OAS NNP cord-302953-gr2kk9w4 307 25 ) ) -RRB- cord-302953-gr2kk9w4 307 26 family family NN cord-302953-gr2kk9w4 307 27 , , , cord-302953-gr2kk9w4 307 28 a a DT cord-302953-gr2kk9w4 307 29 pathway pathway NN cord-302953-gr2kk9w4 307 30 that that WDT cord-302953-gr2kk9w4 307 31 affects affect VBZ cord-302953-gr2kk9w4 307 32 replication replication NN cord-302953-gr2kk9w4 307 33 of of IN cord-302953-gr2kk9w4 307 34 several several JJ cord-302953-gr2kk9w4 307 35 neurotropic neurotropic NNS cord-302953-gr2kk9w4 307 36 viruses virus NNS cord-302953-gr2kk9w4 307 37 , , , cord-302953-gr2kk9w4 307 38 including include VBG cord-302953-gr2kk9w4 307 39 rabies rabies NN cord-302953-gr2kk9w4 307 40 virus virus NN cord-302953-gr2kk9w4 307 41 , , , cord-302953-gr2kk9w4 307 42 canine canine JJ cord-302953-gr2kk9w4 307 43 distemper distemper NN cord-302953-gr2kk9w4 307 44 virus virus NN cord-302953-gr2kk9w4 307 45 , , , cord-302953-gr2kk9w4 307 46 West West NNP cord-302953-gr2kk9w4 307 47 Nile Nile NNP cord-302953-gr2kk9w4 307 48 virus virus NN cord-302953-gr2kk9w4 307 49 ( ( -LRB- cord-302953-gr2kk9w4 307 50 WNV WNV NNP cord-302953-gr2kk9w4 307 51 ) ) -RRB- cord-302953-gr2kk9w4 307 52 , , , cord-302953-gr2kk9w4 307 53 and and CC cord-302953-gr2kk9w4 307 54 JEV JEV NNP cord-302953-gr2kk9w4 307 55 [ [ -LRB- cord-302953-gr2kk9w4 307 56 29 29 CD cord-302953-gr2kk9w4 307 57 , , , cord-302953-gr2kk9w4 307 58 [ [ -LRB- cord-302953-gr2kk9w4 307 59 44 44 CD cord-302953-gr2kk9w4 307 60 ] ] -RRB- cord-302953-gr2kk9w4 307 61 [ [ -LRB- cord-302953-gr2kk9w4 307 62 45 45 CD cord-302953-gr2kk9w4 307 63 ] ] -RRB- cord-302953-gr2kk9w4 307 64 [ [ -LRB- cord-302953-gr2kk9w4 307 65 46 46 CD cord-302953-gr2kk9w4 307 66 ] ] -RRB- cord-302953-gr2kk9w4 307 67 . . . cord-302953-gr2kk9w4 308 1 Two two CD cord-302953-gr2kk9w4 308 2 other other JJ cord-302953-gr2kk9w4 308 3 antiviral antiviral JJ cord-302953-gr2kk9w4 308 4 genes gene NNS cord-302953-gr2kk9w4 308 5 usually usually RB cord-302953-gr2kk9w4 308 6 more more RBR cord-302953-gr2kk9w4 308 7 robustly robustly RB cord-302953-gr2kk9w4 308 8 induced induce VBN cord-302953-gr2kk9w4 308 9 by by IN cord-302953-gr2kk9w4 308 10 type type NN cord-302953-gr2kk9w4 308 11 I -PRON- PRP cord-302953-gr2kk9w4 308 12 than than IN cord-302953-gr2kk9w4 308 13 type type NN cord-302953-gr2kk9w4 308 14 II II NNP cord-302953-gr2kk9w4 308 15 IFNs ifn NNS cord-302953-gr2kk9w4 308 16 , , , cord-302953-gr2kk9w4 308 17 Rsad2 rsad2 JJ cord-302953-gr2kk9w4 309 1 and and CC cord-302953-gr2kk9w4 309 2 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 309 3 , , , cord-302953-gr2kk9w4 309 4 were be VBD cord-302953-gr2kk9w4 309 5 induced induce VBN cord-302953-gr2kk9w4 309 6 later later RB cord-302953-gr2kk9w4 309 7 and and CC cord-302953-gr2kk9w4 309 8 to to IN cord-302953-gr2kk9w4 309 9 lesser less JJR cord-302953-gr2kk9w4 309 10 extents extent NNS cord-302953-gr2kk9w4 309 11 . . . cord-302953-gr2kk9w4 310 1 Rsad2-encoded rsad2-encoded JJ cord-302953-gr2kk9w4 310 2 viperin viperin NNP cord-302953-gr2kk9w4 310 3 can can MD cord-302953-gr2kk9w4 310 4 impair impair VB cord-302953-gr2kk9w4 310 5 budding bud VBG cord-302953-gr2kk9w4 310 6 of of IN cord-302953-gr2kk9w4 310 7 enveloped envelop VBN cord-302953-gr2kk9w4 310 8 viruses virus NNS cord-302953-gr2kk9w4 310 9 [ [ -LRB- cord-302953-gr2kk9w4 310 10 47 47 CD cord-302953-gr2kk9w4 310 11 ] ] -RRB- cord-302953-gr2kk9w4 310 12 [ [ -LRB- cord-302953-gr2kk9w4 310 13 48 48 CD cord-302953-gr2kk9w4 310 14 ] ] -RRB- cord-302953-gr2kk9w4 310 15 [ [ -LRB- cord-302953-gr2kk9w4 310 16 49 49 CD cord-302953-gr2kk9w4 310 17 ] ] -RRB- cord-302953-gr2kk9w4 310 18 and and CC cord-302953-gr2kk9w4 310 19 alphavirus alphavirus NNP cord-302953-gr2kk9w4 310 20 and and CC cord-302953-gr2kk9w4 310 21 flavivirus flavivirus JJ cord-302953-gr2kk9w4 310 22 replication replication NN cord-302953-gr2kk9w4 310 23 and and CC cord-302953-gr2kk9w4 310 24 assembly assembly NN cord-302953-gr2kk9w4 310 25 [ [ -LRB- cord-302953-gr2kk9w4 310 26 50 50 CD cord-302953-gr2kk9w4 310 27 ] ] -RRB- cord-302953-gr2kk9w4 310 28 [ [ -LRB- cord-302953-gr2kk9w4 310 29 51 51 CD cord-302953-gr2kk9w4 310 30 ] ] -RRB- cord-302953-gr2kk9w4 310 31 [ [ -LRB- cord-302953-gr2kk9w4 310 32 52 52 CD cord-302953-gr2kk9w4 310 33 ] ] -RRB- cord-302953-gr2kk9w4 311 1 [ [ -LRB- cord-302953-gr2kk9w4 311 2 53 53 CD cord-302953-gr2kk9w4 311 3 ] ] -RRB- cord-302953-gr2kk9w4 311 4 . . . cord-302953-gr2kk9w4 312 1 Zc3hav1 Zc3hav1 NNP cord-302953-gr2kk9w4 312 2 encodes encode VBZ cord-302953-gr2kk9w4 312 3 zinc zinc NN cord-302953-gr2kk9w4 312 4 - - HYPH cord-302953-gr2kk9w4 312 5 finger finger NN cord-302953-gr2kk9w4 312 6 antiviral antiviral JJ cord-302953-gr2kk9w4 312 7 protein protein NN cord-302953-gr2kk9w4 312 8 ( ( -LRB- cord-302953-gr2kk9w4 312 9 ZAP ZAP NNP cord-302953-gr2kk9w4 312 10 ) ) -RRB- cord-302953-gr2kk9w4 312 11 or or CC cord-302953-gr2kk9w4 312 12 poly(ADP poly(adp NN cord-302953-gr2kk9w4 312 13 - - HYPH cord-302953-gr2kk9w4 312 14 ribose ribose NN cord-302953-gr2kk9w4 312 15 ) ) -RRB- cord-302953-gr2kk9w4 312 16 polymerase-13 polymerase-13 . cord-302953-gr2kk9w4 313 1 ( ( -LRB- cord-302953-gr2kk9w4 313 2 PARP13 PARP13 NNP cord-302953-gr2kk9w4 313 3 ) ) -RRB- cord-302953-gr2kk9w4 313 4 , , , cord-302953-gr2kk9w4 313 5 an an DT cord-302953-gr2kk9w4 313 6 RNA rna NN cord-302953-gr2kk9w4 313 7 - - HYPH cord-302953-gr2kk9w4 313 8 binding bind VBG cord-302953-gr2kk9w4 313 9 protein protein NN cord-302953-gr2kk9w4 313 10 that that WDT cord-302953-gr2kk9w4 313 11 recruits recruit VBZ cord-302953-gr2kk9w4 313 12 RNA RNA NNP cord-302953-gr2kk9w4 313 13 decay decay NN cord-302953-gr2kk9w4 313 14 factors factor NNS cord-302953-gr2kk9w4 313 15 to to TO cord-302953-gr2kk9w4 313 16 degrade degrade VB cord-302953-gr2kk9w4 313 17 viral viral JJ cord-302953-gr2kk9w4 313 18 RNA RNA NNP cord-302953-gr2kk9w4 313 19 and and CC cord-302953-gr2kk9w4 313 20 inhibit inhibit VB cord-302953-gr2kk9w4 313 21 viral viral JJ cord-302953-gr2kk9w4 313 22 RNA RNA NNP cord-302953-gr2kk9w4 313 23 translation translation NN cord-302953-gr2kk9w4 313 24 [ [ -LRB- cord-302953-gr2kk9w4 313 25 54 54 CD cord-302953-gr2kk9w4 313 26 ] ] -RRB- cord-302953-gr2kk9w4 313 27 [ [ -LRB- cord-302953-gr2kk9w4 313 28 55 55 CD cord-302953-gr2kk9w4 313 29 ] ] -RRB- cord-302953-gr2kk9w4 313 30 [ [ -LRB- cord-302953-gr2kk9w4 313 31 56 56 CD cord-302953-gr2kk9w4 313 32 ] ] -RRB- cord-302953-gr2kk9w4 313 33 [ [ -LRB- cord-302953-gr2kk9w4 313 34 57 57 CD cord-302953-gr2kk9w4 313 35 ] ] -RRB- cord-302953-gr2kk9w4 313 36 [ [ -LRB- cord-302953-gr2kk9w4 313 37 58 58 CD cord-302953-gr2kk9w4 313 38 ] ] -RRB- cord-302953-gr2kk9w4 313 39 . . . cord-302953-gr2kk9w4 314 1 However however RB cord-302953-gr2kk9w4 314 2 , , , cord-302953-gr2kk9w4 314 3 the the DT cord-302953-gr2kk9w4 314 4 specific specific JJ cord-302953-gr2kk9w4 314 5 role role NN cord-302953-gr2kk9w4 314 6 for for IN cord-302953-gr2kk9w4 314 7 these these DT cord-302953-gr2kk9w4 314 8 ISGs isg NNS cord-302953-gr2kk9w4 314 9 in in IN cord-302953-gr2kk9w4 314 10 IFN IFN NNP cord-302953-gr2kk9w4 314 11 - - HYPH cord-302953-gr2kk9w4 314 12 γ γ NNP cord-302953-gr2kk9w4 314 13 - - HYPH cord-302953-gr2kk9w4 314 14 mediated mediate VBN cord-302953-gr2kk9w4 314 15 virus virus NN cord-302953-gr2kk9w4 314 16 clearance clearance NN cord-302953-gr2kk9w4 314 17 from from IN cord-302953-gr2kk9w4 314 18 neurons neuron NNS cord-302953-gr2kk9w4 314 19 will will MD cord-302953-gr2kk9w4 314 20 require require VB cord-302953-gr2kk9w4 314 21 further further JJ cord-302953-gr2kk9w4 314 22 study study NN cord-302953-gr2kk9w4 314 23 . . . cord-302953-gr2kk9w4 315 1 The the DT cord-302953-gr2kk9w4 315 2 current current JJ cord-302953-gr2kk9w4 315 3 studies study NNS cord-302953-gr2kk9w4 315 4 show show VBP cord-302953-gr2kk9w4 315 5 that that IN cord-302953-gr2kk9w4 315 6 the the DT cord-302953-gr2kk9w4 315 7 in in IN cord-302953-gr2kk9w4 315 8 vivo vivo NN cord-302953-gr2kk9w4 315 9 role role NN cord-302953-gr2kk9w4 315 10 of of IN cord-302953-gr2kk9w4 315 11 IFN IFN NNP cord-302953-gr2kk9w4 315 12 - - HYPH cord-302953-gr2kk9w4 315 13 γ γ NNP cord-302953-gr2kk9w4 315 14 in in IN cord-302953-gr2kk9w4 315 15 pathogenesis pathogenesis NN cord-302953-gr2kk9w4 315 16 of of IN cord-302953-gr2kk9w4 315 17 SINV SINV NNP cord-302953-gr2kk9w4 315 18 - - HYPH cord-302953-gr2kk9w4 315 19 induced induce VBN cord-302953-gr2kk9w4 315 20 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 315 21 is be VBZ cord-302953-gr2kk9w4 315 22 complex complex JJ cord-302953-gr2kk9w4 315 23 . . . cord-302953-gr2kk9w4 316 1 Although although IN cord-302953-gr2kk9w4 316 2 IFN IFN NNP cord-302953-gr2kk9w4 316 3 - - HYPH cord-302953-gr2kk9w4 316 4 γ γ NNP cord-302953-gr2kk9w4 316 5 is be VBZ cord-302953-gr2kk9w4 316 6 important important JJ cord-302953-gr2kk9w4 316 7 for for IN cord-302953-gr2kk9w4 316 8 clearance clearance NN cord-302953-gr2kk9w4 316 9 of of IN cord-302953-gr2kk9w4 316 10 infectious infectious JJ cord-302953-gr2kk9w4 316 11 virus virus NN cord-302953-gr2kk9w4 316 12 , , , cord-302953-gr2kk9w4 316 13 particularly particularly RB cord-302953-gr2kk9w4 316 14 from from IN cord-302953-gr2kk9w4 316 15 spinal spinal JJ cord-302953-gr2kk9w4 316 16 cord cord NN cord-302953-gr2kk9w4 316 17 neurons neuron NNS cord-302953-gr2kk9w4 316 18 [ [ -LRB- cord-302953-gr2kk9w4 316 19 7 7 CD cord-302953-gr2kk9w4 316 20 , , , cord-302953-gr2kk9w4 316 21 30 30 CD cord-302953-gr2kk9w4 316 22 ] ] -RRB- cord-302953-gr2kk9w4 316 23 , , , cord-302953-gr2kk9w4 316 24 and and CC cord-302953-gr2kk9w4 316 25 was be VBD cord-302953-gr2kk9w4 316 26 sufficient sufficient JJ cord-302953-gr2kk9w4 316 27 for for IN cord-302953-gr2kk9w4 316 28 viral viral JJ cord-302953-gr2kk9w4 316 29 RNA RNA NNP cord-302953-gr2kk9w4 316 30 clearance clearance NN cord-302953-gr2kk9w4 316 31 in in IN cord-302953-gr2kk9w4 316 32 neurons neuron NNS cord-302953-gr2kk9w4 316 33 in in IN cord-302953-gr2kk9w4 316 34 vitro vitro FW cord-302953-gr2kk9w4 316 35 , , , cord-302953-gr2kk9w4 316 36 IFN IFN NNP cord-302953-gr2kk9w4 316 37 - - HYPH cord-302953-gr2kk9w4 316 38 γ γ NNP cord-302953-gr2kk9w4 316 39 delayed delay VBD cord-302953-gr2kk9w4 316 40 clearance clearance NN cord-302953-gr2kk9w4 316 41 initiation initiation NN cord-302953-gr2kk9w4 316 42 of of IN cord-302953-gr2kk9w4 316 43 viral viral JJ cord-302953-gr2kk9w4 316 44 RNA RNA NNP cord-302953-gr2kk9w4 316 45 from from IN cord-302953-gr2kk9w4 316 46 both both CC cord-302953-gr2kk9w4 316 47 the the DT cord-302953-gr2kk9w4 316 48 brain brain NN cord-302953-gr2kk9w4 316 49 and and CC cord-302953-gr2kk9w4 316 50 spinal spinal JJ cord-302953-gr2kk9w4 316 51 cord cord NN cord-302953-gr2kk9w4 316 52 in in IN cord-302953-gr2kk9w4 316 53 mice mouse NNS cord-302953-gr2kk9w4 316 54 ( ( -LRB- cord-302953-gr2kk9w4 316 55 Figure figure NN cord-302953-gr2kk9w4 316 56 5 5 CD cord-302953-gr2kk9w4 316 57 ) ) -RRB- cord-302953-gr2kk9w4 316 58 , , , cord-302953-gr2kk9w4 316 59 suggesting suggest VBG cord-302953-gr2kk9w4 316 60 an an DT cord-302953-gr2kk9w4 316 61 extra extra JJ cord-302953-gr2kk9w4 316 62 neuronal neuronal JJ cord-302953-gr2kk9w4 316 63 effect effect NN cord-302953-gr2kk9w4 316 64 that that WDT cord-302953-gr2kk9w4 316 65 secondarily secondarily RB cord-302953-gr2kk9w4 316 66 affects affect VBZ cord-302953-gr2kk9w4 316 67 viral viral JJ cord-302953-gr2kk9w4 316 68 RNA RNA NNP cord-302953-gr2kk9w4 316 69 clearance clearance NN cord-302953-gr2kk9w4 316 70 . . . cord-302953-gr2kk9w4 317 1 IFN IFN NNP cord-302953-gr2kk9w4 317 2 - - HYPH cord-302953-gr2kk9w4 317 3 γ γ NNP cord-302953-gr2kk9w4 317 4 signaling signal VBG cord-302953-gr2kk9w4 317 5 improved improve VBN cord-302953-gr2kk9w4 317 6 recruitment recruitment NN cord-302953-gr2kk9w4 317 7 of of IN cord-302953-gr2kk9w4 317 8 NK NK NNP cord-302953-gr2kk9w4 317 9 cells cell NNS cord-302953-gr2kk9w4 317 10 but but CC cord-302953-gr2kk9w4 317 11 differentially differentially RB cord-302953-gr2kk9w4 317 12 affected affect VBD cord-302953-gr2kk9w4 317 13 the the DT cord-302953-gr2kk9w4 317 14 recruitment recruitment NN cord-302953-gr2kk9w4 317 15 of of IN cord-302953-gr2kk9w4 317 16 T T NNP cord-302953-gr2kk9w4 317 17 cells cell NNS cord-302953-gr2kk9w4 317 18 , , , cord-302953-gr2kk9w4 317 19 with with IN cord-302953-gr2kk9w4 317 20 more more JJR cord-302953-gr2kk9w4 317 21 CD4 CD4 NNP cord-302953-gr2kk9w4 317 22 + + CC cord-302953-gr2kk9w4 317 23 T t NN cord-302953-gr2kk9w4 317 24 cells cell NNS cord-302953-gr2kk9w4 317 25 and and CC cord-302953-gr2kk9w4 317 26 fewer few JJR cord-302953-gr2kk9w4 317 27 CD8 CD8 NNS cord-302953-gr2kk9w4 317 28 + + CC cord-302953-gr2kk9w4 317 29 T t NN cord-302953-gr2kk9w4 317 30 cells cell NNS cord-302953-gr2kk9w4 317 31 infiltrating infiltrate VBG cord-302953-gr2kk9w4 317 32 the the DT cord-302953-gr2kk9w4 317 33 brains brain NNS cord-302953-gr2kk9w4 317 34 of of IN cord-302953-gr2kk9w4 317 35 SINV SINV NNP cord-302953-gr2kk9w4 317 36 - - HYPH cord-302953-gr2kk9w4 317 37 infected infect VBN cord-302953-gr2kk9w4 317 38 WT WT NNP cord-302953-gr2kk9w4 317 39 mice mouse NNS cord-302953-gr2kk9w4 317 40 than than IN cord-302953-gr2kk9w4 317 41 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 318 1 −/− −/− NNP cord-302953-gr2kk9w4 318 2 or or CC cord-302953-gr2kk9w4 318 3 Ifng Ifng NNP cord-302953-gr2kk9w4 318 4 −/− −/− NNP cord-302953-gr2kk9w4 318 5 mice mouse NNS cord-302953-gr2kk9w4 318 6 . . . cord-302953-gr2kk9w4 319 1 This this DT cord-302953-gr2kk9w4 319 2 modification modification NN cord-302953-gr2kk9w4 319 3 of of IN cord-302953-gr2kk9w4 319 4 the the DT cord-302953-gr2kk9w4 319 5 local local JJ cord-302953-gr2kk9w4 319 6 T T NNP cord-302953-gr2kk9w4 319 7 cell cell NN cord-302953-gr2kk9w4 319 8 response response NN cord-302953-gr2kk9w4 319 9 potentially potentially RB cord-302953-gr2kk9w4 319 10 explains explain VBZ cord-302953-gr2kk9w4 319 11 the the DT cord-302953-gr2kk9w4 319 12 differential differential JJ cord-302953-gr2kk9w4 319 13 initiation initiation NN cord-302953-gr2kk9w4 319 14 of of IN cord-302953-gr2kk9w4 319 15 RNA RNA NNP cord-302953-gr2kk9w4 319 16 clearance clearance NN cord-302953-gr2kk9w4 319 17 among among IN cord-302953-gr2kk9w4 319 18 mice mouse NNS cord-302953-gr2kk9w4 319 19 with with IN cord-302953-gr2kk9w4 319 20 intact intact JJ cord-302953-gr2kk9w4 319 21 and and CC cord-302953-gr2kk9w4 319 22 impaired impair VBD cord-302953-gr2kk9w4 319 23 IFN IFN NNP cord-302953-gr2kk9w4 319 24 - - HYPH cord-302953-gr2kk9w4 319 25 γ γ NNP cord-302953-gr2kk9w4 319 26 signaling signaling NN cord-302953-gr2kk9w4 319 27 , , , cord-302953-gr2kk9w4 319 28 leading lead VBG cord-302953-gr2kk9w4 319 29 us -PRON- PRP cord-302953-gr2kk9w4 319 30 to to TO cord-302953-gr2kk9w4 319 31 further further RB cord-302953-gr2kk9w4 319 32 evaluate evaluate VB cord-302953-gr2kk9w4 319 33 the the DT cord-302953-gr2kk9w4 319 34 composition composition NN cord-302953-gr2kk9w4 319 35 and and CC cord-302953-gr2kk9w4 319 36 functionality functionality NN cord-302953-gr2kk9w4 319 37 of of IN cord-302953-gr2kk9w4 319 38 these these DT cord-302953-gr2kk9w4 319 39 T t NN cord-302953-gr2kk9w4 319 40 cells cell NNS cord-302953-gr2kk9w4 319 41 . . . cord-302953-gr2kk9w4 320 1 CD4 CD4 NNP cord-302953-gr2kk9w4 320 2 + + CC cord-302953-gr2kk9w4 320 3 T t NN cord-302953-gr2kk9w4 320 4 cells cell NNS cord-302953-gr2kk9w4 320 5 primarily primarily RB cord-302953-gr2kk9w4 320 6 exert exert VBP cord-302953-gr2kk9w4 320 7 their -PRON- PRP$ cord-302953-gr2kk9w4 320 8 effects effect NNS cord-302953-gr2kk9w4 320 9 via via IN cord-302953-gr2kk9w4 320 10 cytokine cytokine NN cord-302953-gr2kk9w4 320 11 secretion secretion NN cord-302953-gr2kk9w4 320 12 , , , cord-302953-gr2kk9w4 320 13 which which WDT cord-302953-gr2kk9w4 320 14 identify identify VBP cord-302953-gr2kk9w4 320 15 Th th DT cord-302953-gr2kk9w4 320 16 subsets subset NNS cord-302953-gr2kk9w4 320 17 that that WDT cord-302953-gr2kk9w4 320 18 influence influence VBP cord-302953-gr2kk9w4 320 19 the the DT cord-302953-gr2kk9w4 320 20 differentiation differentiation NN cord-302953-gr2kk9w4 320 21 and and CC cord-302953-gr2kk9w4 320 22 activation activation NN cord-302953-gr2kk9w4 320 23 of of IN cord-302953-gr2kk9w4 320 24 other other JJ cord-302953-gr2kk9w4 320 25 immune immune JJ cord-302953-gr2kk9w4 320 26 cells cell NNS cord-302953-gr2kk9w4 320 27 [ [ -LRB- cord-302953-gr2kk9w4 320 28 59 59 CD cord-302953-gr2kk9w4 320 29 ] ] -RRB- cord-302953-gr2kk9w4 320 30 . . . cord-302953-gr2kk9w4 321 1 Treg Treg NNP cord-302953-gr2kk9w4 321 2 cells cell NNS cord-302953-gr2kk9w4 321 3 , , , cord-302953-gr2kk9w4 321 4 defined define VBN cord-302953-gr2kk9w4 321 5 by by IN cord-302953-gr2kk9w4 321 6 expression expression NN cord-302953-gr2kk9w4 321 7 of of IN cord-302953-gr2kk9w4 321 8 both both CC cord-302953-gr2kk9w4 321 9 Foxp3 foxp3 JJ cord-302953-gr2kk9w4 321 10 and and CC cord-302953-gr2kk9w4 321 11 CD25 CD25 NNP cord-302953-gr2kk9w4 321 12 , , , cord-302953-gr2kk9w4 321 13 tended tend VBD cord-302953-gr2kk9w4 321 14 to to TO cord-302953-gr2kk9w4 321 15 be be VB cord-302953-gr2kk9w4 321 16 lower low JJR cord-302953-gr2kk9w4 321 17 in in IN cord-302953-gr2kk9w4 321 18 Ifng Ifng NNP cord-302953-gr2kk9w4 321 19 −/− −/− NNP cord-302953-gr2kk9w4 321 20 mouse mouse NN cord-302953-gr2kk9w4 321 21 brains brain NNS cord-302953-gr2kk9w4 321 22 , , , cord-302953-gr2kk9w4 321 23 and and CC cord-302953-gr2kk9w4 321 24 mRNA mrna NN cord-302953-gr2kk9w4 321 25 expression expression NN cord-302953-gr2kk9w4 321 26 of of IN cord-302953-gr2kk9w4 321 27 the the DT cord-302953-gr2kk9w4 321 28 regulatory regulatory JJ cord-302953-gr2kk9w4 321 29 cytokine cytokine NN cord-302953-gr2kk9w4 321 30 IL-10 IL-10 NNP cord-302953-gr2kk9w4 321 31 was be VBD cord-302953-gr2kk9w4 321 32 significantly significantly RB cord-302953-gr2kk9w4 321 33 lower low JJR cord-302953-gr2kk9w4 321 34 compared compare VBN cord-302953-gr2kk9w4 321 35 to to IN cord-302953-gr2kk9w4 321 36 WT WT NNP cord-302953-gr2kk9w4 321 37 and and CC cord-302953-gr2kk9w4 321 38 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 321 39 −/− −/− NNP cord-302953-gr2kk9w4 321 40 mice mouse NNS cord-302953-gr2kk9w4 321 41 at at IN cord-302953-gr2kk9w4 321 42 7 7 CD cord-302953-gr2kk9w4 321 43 DPI DPI NNP cord-302953-gr2kk9w4 321 44 . . . cord-302953-gr2kk9w4 322 1 Th17 Th17 NNP cord-302953-gr2kk9w4 323 1 cells cell NNS cord-302953-gr2kk9w4 323 2 have have VBP cord-302953-gr2kk9w4 323 3 been be VBN cord-302953-gr2kk9w4 323 4 associated associate VBN cord-302953-gr2kk9w4 323 5 with with IN cord-302953-gr2kk9w4 323 6 fatal fatal JJ cord-302953-gr2kk9w4 323 7 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 323 8 and and CC cord-302953-gr2kk9w4 323 9 virus virus NN cord-302953-gr2kk9w4 323 10 persistence persistence NN cord-302953-gr2kk9w4 323 11 during during IN cord-302953-gr2kk9w4 323 12 infection infection NN cord-302953-gr2kk9w4 323 13 with with IN cord-302953-gr2kk9w4 323 14 several several JJ cord-302953-gr2kk9w4 323 15 viruses virus NNS cord-302953-gr2kk9w4 323 16 , , , cord-302953-gr2kk9w4 323 17 such such JJ cord-302953-gr2kk9w4 323 18 as as IN cord-302953-gr2kk9w4 323 19 SINV SINV NNP cord-302953-gr2kk9w4 323 20 NSV NSV NNP cord-302953-gr2kk9w4 323 21 , , , cord-302953-gr2kk9w4 323 22 TMEV TMEV NNP cord-302953-gr2kk9w4 323 23 , , , cord-302953-gr2kk9w4 323 24 and and CC cord-302953-gr2kk9w4 323 25 JHMV JHMV NNP cord-302953-gr2kk9w4 323 26 , , , cord-302953-gr2kk9w4 323 27 especially especially RB cord-302953-gr2kk9w4 323 28 in in IN cord-302953-gr2kk9w4 323 29 the the DT cord-302953-gr2kk9w4 323 30 absence absence NN cord-302953-gr2kk9w4 323 31 of of IN cord-302953-gr2kk9w4 323 32 IFN IFN NNP cord-302953-gr2kk9w4 323 33 - - HYPH cord-302953-gr2kk9w4 323 34 γ γ NNP cord-302953-gr2kk9w4 323 35 [ [ -LRB- cord-302953-gr2kk9w4 323 36 12 12 CD cord-302953-gr2kk9w4 323 37 , , , cord-302953-gr2kk9w4 323 38 [ [ -LRB- cord-302953-gr2kk9w4 323 39 60 60 CD cord-302953-gr2kk9w4 323 40 ] ] -RRB- cord-302953-gr2kk9w4 323 41 [ [ -LRB- cord-302953-gr2kk9w4 323 42 61 61 CD cord-302953-gr2kk9w4 323 43 ] ] -RRB- cord-302953-gr2kk9w4 323 44 [ [ -LRB- cord-302953-gr2kk9w4 323 45 62 62 CD cord-302953-gr2kk9w4 323 46 ] ] -RRB- cord-302953-gr2kk9w4 323 47 . . . cord-302953-gr2kk9w4 324 1 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 325 1 −/− −/− NNP cord-302953-gr2kk9w4 325 2 mice mouse NNS cord-302953-gr2kk9w4 325 3 expressed express VBD cord-302953-gr2kk9w4 325 4 more more JJR cord-302953-gr2kk9w4 325 5 Il17a il17a NN cord-302953-gr2kk9w4 325 6 mRNA mrna NN cord-302953-gr2kk9w4 325 7 and and CC cord-302953-gr2kk9w4 325 8 trended trend VBD cord-302953-gr2kk9w4 325 9 toward toward IN cord-302953-gr2kk9w4 325 10 increased increase VBN cord-302953-gr2kk9w4 325 11 IL-17a IL-17a NNP cord-302953-gr2kk9w4 325 12 production production NN cord-302953-gr2kk9w4 325 13 by by IN cord-302953-gr2kk9w4 325 14 CD4 CD4 NNP cord-302953-gr2kk9w4 325 15 + + CC cord-302953-gr2kk9w4 325 16 T t NN cord-302953-gr2kk9w4 325 17 cells cell NNS cord-302953-gr2kk9w4 325 18 compared compare VBN cord-302953-gr2kk9w4 325 19 to to IN cord-302953-gr2kk9w4 325 20 WT WT NNP cord-302953-gr2kk9w4 325 21 and and CC cord-302953-gr2kk9w4 325 22 Ifng Ifng NNP cord-302953-gr2kk9w4 325 23 −/− −/− NNP cord-302953-gr2kk9w4 325 24 mice mouse NNS cord-302953-gr2kk9w4 325 25 . . . cord-302953-gr2kk9w4 326 1 Similar similar JJ cord-302953-gr2kk9w4 326 2 results result NNS cord-302953-gr2kk9w4 326 3 were be VBD cord-302953-gr2kk9w4 326 4 seen see VBN cord-302953-gr2kk9w4 326 5 in in IN cord-302953-gr2kk9w4 326 6 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 327 1 −/− −/− NNP cord-302953-gr2kk9w4 327 2 mice mouse NNS cord-302953-gr2kk9w4 327 3 infected infect VBN cord-302953-gr2kk9w4 327 4 with with IN cord-302953-gr2kk9w4 327 5 SINV SINV NNP cord-302953-gr2kk9w4 327 6 NSV NSV NNP cord-302953-gr2kk9w4 327 7 and and CC cord-302953-gr2kk9w4 327 8 suggest suggest VBP cord-302953-gr2kk9w4 327 9 preferential preferential JJ cord-302953-gr2kk9w4 327 10 expansion expansion NN cord-302953-gr2kk9w4 327 11 of of IN cord-302953-gr2kk9w4 327 12 Th17 Th17 NNP cord-302953-gr2kk9w4 327 13 cells cell NNS cord-302953-gr2kk9w4 327 14 [ [ -LRB- cord-302953-gr2kk9w4 327 15 30 30 CD cord-302953-gr2kk9w4 327 16 ] ] -RRB- cord-302953-gr2kk9w4 327 17 . . . cord-302953-gr2kk9w4 328 1 Neutrophils neutrophils NN cord-302953-gr2kk9w4 328 2 , , , cord-302953-gr2kk9w4 328 3 also also RB cord-302953-gr2kk9w4 328 4 associated associate VBN cord-302953-gr2kk9w4 328 5 with with IN cord-302953-gr2kk9w4 328 6 a a DT cord-302953-gr2kk9w4 328 7 Th17 th17 NN cord-302953-gr2kk9w4 328 8 profile profile NN cord-302953-gr2kk9w4 328 9 [ [ -LRB- cord-302953-gr2kk9w4 328 10 63 63 CD cord-302953-gr2kk9w4 328 11 ] ] -RRB- cord-302953-gr2kk9w4 328 12 , , , cord-302953-gr2kk9w4 328 13 were be VBD cord-302953-gr2kk9w4 328 14 also also RB cord-302953-gr2kk9w4 328 15 increased increase VBN cord-302953-gr2kk9w4 328 16 in in IN cord-302953-gr2kk9w4 328 17 brains brain NNS cord-302953-gr2kk9w4 328 18 of of IN cord-302953-gr2kk9w4 328 19 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 328 20 −/− −/− NNP cord-302953-gr2kk9w4 328 21 mice mouse NNS cord-302953-gr2kk9w4 328 22 . . . cord-302953-gr2kk9w4 329 1 These these DT cord-302953-gr2kk9w4 329 2 results result NNS cord-302953-gr2kk9w4 329 3 show show VBP cord-302953-gr2kk9w4 329 4 that that IN cord-302953-gr2kk9w4 329 5 IFN IFN NNP cord-302953-gr2kk9w4 329 6 - - HYPH cord-302953-gr2kk9w4 329 7 γ γ NNP cord-302953-gr2kk9w4 329 8 signaling signaling NN cord-302953-gr2kk9w4 329 9 affects affect VBZ cord-302953-gr2kk9w4 329 10 CD4 CD4 NNP cord-302953-gr2kk9w4 329 11 + + CC cord-302953-gr2kk9w4 329 12 T T NNP cord-302953-gr2kk9w4 329 13 cell cell NN cord-302953-gr2kk9w4 329 14 function function NN cord-302953-gr2kk9w4 329 15 , , , cord-302953-gr2kk9w4 329 16 although although IN cord-302953-gr2kk9w4 329 17 major major JJ cord-302953-gr2kk9w4 329 18 differences difference NNS cord-302953-gr2kk9w4 329 19 in in IN cord-302953-gr2kk9w4 329 20 Th th DT cord-302953-gr2kk9w4 329 21 profile profile NN cord-302953-gr2kk9w4 329 22 were be VBD cord-302953-gr2kk9w4 329 23 not not RB cord-302953-gr2kk9w4 329 24 seen see VBN cord-302953-gr2kk9w4 329 25 , , , cord-302953-gr2kk9w4 329 26 and and CC cord-302953-gr2kk9w4 329 27 reiterates reiterate VBZ cord-302953-gr2kk9w4 329 28 the the DT cord-302953-gr2kk9w4 329 29 differences difference NNS cord-302953-gr2kk9w4 329 30 between between IN cord-302953-gr2kk9w4 329 31 mice mouse NNS cord-302953-gr2kk9w4 329 32 lacking lack VBG cord-302953-gr2kk9w4 329 33 IFN IFN NNP cord-302953-gr2kk9w4 329 34 - - HYPH cord-302953-gr2kk9w4 329 35 γ γ NN cord-302953-gr2kk9w4 329 36 production production NN cord-302953-gr2kk9w4 329 37 and and CC cord-302953-gr2kk9w4 329 38 mice mouse NNS cord-302953-gr2kk9w4 329 39 with with IN cord-302953-gr2kk9w4 329 40 impaired impaired JJ cord-302953-gr2kk9w4 329 41 receptor receptor NN cord-302953-gr2kk9w4 329 42 function function NN cord-302953-gr2kk9w4 329 43 in in IN cord-302953-gr2kk9w4 329 44 the the DT cord-302953-gr2kk9w4 329 45 immune immune JJ cord-302953-gr2kk9w4 329 46 response response NN cord-302953-gr2kk9w4 329 47 to to IN cord-302953-gr2kk9w4 329 48 SINV SINV NNP cord-302953-gr2kk9w4 329 49 infection infection NN cord-302953-gr2kk9w4 329 50 . . . cord-302953-gr2kk9w4 330 1 In in IN cord-302953-gr2kk9w4 330 2 our -PRON- PRP$ cord-302953-gr2kk9w4 330 3 mouse mouse NN cord-302953-gr2kk9w4 330 4 model model NN cord-302953-gr2kk9w4 330 5 of of IN cord-302953-gr2kk9w4 330 6 alphavirus alphavirus NNP cord-302953-gr2kk9w4 330 7 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 330 8 , , , cord-302953-gr2kk9w4 330 9 fewer few JJR cord-302953-gr2kk9w4 330 10 CD8 CD8 NNS cord-302953-gr2kk9w4 330 11 + + CC cord-302953-gr2kk9w4 330 12 T T NNP cord-302953-gr2kk9w4 330 13 cells cell NNS cord-302953-gr2kk9w4 330 14 infiltrated infiltrate VBD cord-302953-gr2kk9w4 330 15 the the DT cord-302953-gr2kk9w4 330 16 CNS CNS NNP cord-302953-gr2kk9w4 330 17 in in IN cord-302953-gr2kk9w4 330 18 WT WT NNP cord-302953-gr2kk9w4 330 19 mice mouse NNS cord-302953-gr2kk9w4 330 20 with with IN cord-302953-gr2kk9w4 330 21 intact intact JJ cord-302953-gr2kk9w4 330 22 IFN IFN NNP cord-302953-gr2kk9w4 330 23 - - HYPH cord-302953-gr2kk9w4 330 24 γ γ NNP cord-302953-gr2kk9w4 330 25 signaling signaling NN cord-302953-gr2kk9w4 330 26 , , , cord-302953-gr2kk9w4 330 27 an an DT cord-302953-gr2kk9w4 330 28 effect effect NN cord-302953-gr2kk9w4 330 29 similar similar JJ cord-302953-gr2kk9w4 330 30 to to IN cord-302953-gr2kk9w4 330 31 the the DT cord-302953-gr2kk9w4 330 32 suppression suppression NN cord-302953-gr2kk9w4 330 33 of of IN cord-302953-gr2kk9w4 330 34 the the DT cord-302953-gr2kk9w4 330 35 CD8 CD8 NNP cord-302953-gr2kk9w4 330 36 + + CC cord-302953-gr2kk9w4 330 37 T T NNP cord-302953-gr2kk9w4 330 38 cell cell NN cord-302953-gr2kk9w4 330 39 response response NN cord-302953-gr2kk9w4 330 40 to to IN cord-302953-gr2kk9w4 330 41 Friend friend NN cord-302953-gr2kk9w4 330 42 virus virus NN cord-302953-gr2kk9w4 330 43 infection infection NN cord-302953-gr2kk9w4 330 44 observed observe VBD cord-302953-gr2kk9w4 330 45 in in IN cord-302953-gr2kk9w4 330 46 association association NN cord-302953-gr2kk9w4 330 47 with with IN cord-302953-gr2kk9w4 330 48 lactate lactate NN cord-302953-gr2kk9w4 330 49 dehydrogenase dehydrogenase NN cord-302953-gr2kk9w4 330 50 virus virus NN cord-302953-gr2kk9w4 330 51 - - HYPH cord-302953-gr2kk9w4 330 52 induced induce VBN cord-302953-gr2kk9w4 330 53 IFN IFN NNP cord-302953-gr2kk9w4 330 54 - - HYPH cord-302953-gr2kk9w4 330 55 γ γ NNP cord-302953-gr2kk9w4 330 56 [ [ -LRB- cord-302953-gr2kk9w4 330 57 64 64 CD cord-302953-gr2kk9w4 330 58 ] ] -RRB- cord-302953-gr2kk9w4 330 59 . . . cord-302953-gr2kk9w4 331 1 As as IN cord-302953-gr2kk9w4 331 2 with with IN cord-302953-gr2kk9w4 331 3 NK NK NNP cord-302953-gr2kk9w4 331 4 cells cell NNS cord-302953-gr2kk9w4 331 5 , , , cord-302953-gr2kk9w4 331 6 CD8 CD8 NNP cord-302953-gr2kk9w4 331 7 + + CC cord-302953-gr2kk9w4 331 8 T T NNP cord-302953-gr2kk9w4 331 9 cells cell NNS cord-302953-gr2kk9w4 331 10 primarily primarily RB cord-302953-gr2kk9w4 331 11 exert exert VBP cord-302953-gr2kk9w4 331 12 their -PRON- PRP$ cord-302953-gr2kk9w4 331 13 effector effector NN cord-302953-gr2kk9w4 331 14 function function NN cord-302953-gr2kk9w4 331 15 against against IN cord-302953-gr2kk9w4 331 16 virus virus NN cord-302953-gr2kk9w4 331 17 infections infection NNS cord-302953-gr2kk9w4 331 18 through through IN cord-302953-gr2kk9w4 331 19 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 331 20 activity activity NN cord-302953-gr2kk9w4 331 21 and and CC cord-302953-gr2kk9w4 331 22 produce produce VB cord-302953-gr2kk9w4 331 23 granzymes granzyme NNS cord-302953-gr2kk9w4 331 24 and and CC cord-302953-gr2kk9w4 331 25 perforin perforin NNP cord-302953-gr2kk9w4 331 26 for for IN cord-302953-gr2kk9w4 331 27 delivery delivery NN cord-302953-gr2kk9w4 331 28 through through IN cord-302953-gr2kk9w4 331 29 granule granule NN cord-302953-gr2kk9w4 331 30 exocytosis exocytosis NN cord-302953-gr2kk9w4 331 31 to to TO cord-302953-gr2kk9w4 331 32 activate activate VB cord-302953-gr2kk9w4 331 33 caspases caspase NNS cord-302953-gr2kk9w4 331 34 and and CC cord-302953-gr2kk9w4 331 35 induce induce VB cord-302953-gr2kk9w4 331 36 target target NN cord-302953-gr2kk9w4 331 37 cell cell NN cord-302953-gr2kk9w4 331 38 apoptosis apoptosis NN cord-302953-gr2kk9w4 331 39 [ [ -LRB- cord-302953-gr2kk9w4 331 40 34 34 CD cord-302953-gr2kk9w4 331 41 ] ] -RRB- cord-302953-gr2kk9w4 331 42 . . . cord-302953-gr2kk9w4 332 1 A a DT cord-302953-gr2kk9w4 332 2 clear clear JJ cord-302953-gr2kk9w4 332 3 role role NN cord-302953-gr2kk9w4 332 4 for for IN cord-302953-gr2kk9w4 332 5 NK NK NNP cord-302953-gr2kk9w4 332 6 cells cell NNS cord-302953-gr2kk9w4 332 7 in in IN cord-302953-gr2kk9w4 332 8 pathogenesis pathogenesis NN cord-302953-gr2kk9w4 332 9 of of IN cord-302953-gr2kk9w4 332 10 alphavirus alphavirus NNP cord-302953-gr2kk9w4 332 11 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 332 12 has have VBZ cord-302953-gr2kk9w4 332 13 not not RB cord-302953-gr2kk9w4 332 14 been be VBN cord-302953-gr2kk9w4 332 15 identified identify VBN cord-302953-gr2kk9w4 332 16 [ [ -LRB- cord-302953-gr2kk9w4 332 17 65 65 CD cord-302953-gr2kk9w4 332 18 , , , cord-302953-gr2kk9w4 332 19 66 66 CD cord-302953-gr2kk9w4 332 20 ] ] -RRB- cord-302953-gr2kk9w4 332 21 and and CC cord-302953-gr2kk9w4 332 22 , , , cord-302953-gr2kk9w4 332 23 in in IN cord-302953-gr2kk9w4 332 24 the the DT cord-302953-gr2kk9w4 332 25 current current JJ cord-302953-gr2kk9w4 332 26 studies study NNS cord-302953-gr2kk9w4 332 27 , , , cord-302953-gr2kk9w4 332 28 greater great JJR cord-302953-gr2kk9w4 332 29 numbers number NNS cord-302953-gr2kk9w4 332 30 of of IN cord-302953-gr2kk9w4 332 31 NK NK NNP cord-302953-gr2kk9w4 332 32 cells cell NNS cord-302953-gr2kk9w4 332 33 and and CC cord-302953-gr2kk9w4 332 34 granzyme granzyme NNS cord-302953-gr2kk9w4 333 1 A a DT cord-302953-gr2kk9w4 333 2 expression expression NN cord-302953-gr2kk9w4 333 3 in in IN cord-302953-gr2kk9w4 333 4 WT WT NNP cord-302953-gr2kk9w4 333 5 mice mouse NNS cord-302953-gr2kk9w4 333 6 did do VBD cord-302953-gr2kk9w4 333 7 not not RB cord-302953-gr2kk9w4 333 8 offset offset VB cord-302953-gr2kk9w4 333 9 the the DT cord-302953-gr2kk9w4 333 10 diminished diminished JJ cord-302953-gr2kk9w4 333 11 CD8 CD8 NNP cord-302953-gr2kk9w4 333 12 + + CC cord-302953-gr2kk9w4 333 13 T T NNP cord-302953-gr2kk9w4 333 14 cell cell NN cord-302953-gr2kk9w4 333 15 response response NN cord-302953-gr2kk9w4 333 16 . . . cord-302953-gr2kk9w4 334 1 Specific specific JJ cord-302953-gr2kk9w4 334 2 targeting targeting NN cord-302953-gr2kk9w4 334 3 of of IN cord-302953-gr2kk9w4 334 4 infected infected JJ cord-302953-gr2kk9w4 334 5 cells cell NNS cord-302953-gr2kk9w4 334 6 by by IN cord-302953-gr2kk9w4 334 7 CD8 CD8 NNP cord-302953-gr2kk9w4 334 8 + + CC cord-302953-gr2kk9w4 334 9 T T NNP cord-302953-gr2kk9w4 334 10 cells cell NNS cord-302953-gr2kk9w4 334 11 is be VBZ cord-302953-gr2kk9w4 334 12 achieved achieve VBN cord-302953-gr2kk9w4 334 13 through through IN cord-302953-gr2kk9w4 334 14 direct direct JJ cord-302953-gr2kk9w4 334 15 contact contact NN cord-302953-gr2kk9w4 334 16 with with IN cord-302953-gr2kk9w4 334 17 an an DT cord-302953-gr2kk9w4 334 18 infected infected JJ cord-302953-gr2kk9w4 334 19 cell cell NN cord-302953-gr2kk9w4 334 20 expressing express VBG cord-302953-gr2kk9w4 334 21 MHC MHC NNP cord-302953-gr2kk9w4 334 22 Class Class NNP cord-302953-gr2kk9w4 334 23 I -PRON- PRP cord-302953-gr2kk9w4 334 24 molecules molecule NNS cord-302953-gr2kk9w4 334 25 . . . cord-302953-gr2kk9w4 335 1 Neurons neuron NNS cord-302953-gr2kk9w4 335 2 have have VBP cord-302953-gr2kk9w4 335 3 a a DT cord-302953-gr2kk9w4 335 4 limited limited JJ cord-302953-gr2kk9w4 335 5 capacity capacity NN cord-302953-gr2kk9w4 335 6 for for IN cord-302953-gr2kk9w4 335 7 MHC MHC NNP cord-302953-gr2kk9w4 335 8 class class NN cord-302953-gr2kk9w4 335 9 I -PRON- PRP cord-302953-gr2kk9w4 335 10 expression expression NN cord-302953-gr2kk9w4 335 11 [ [ -LRB- cord-302953-gr2kk9w4 335 12 2 2 CD cord-302953-gr2kk9w4 335 13 , , , cord-302953-gr2kk9w4 335 14 [ [ -LRB- cord-302953-gr2kk9w4 335 15 67 67 CD cord-302953-gr2kk9w4 335 16 ] ] -RRB- cord-302953-gr2kk9w4 336 1 [ [ -LRB- cord-302953-gr2kk9w4 336 2 68 68 CD cord-302953-gr2kk9w4 336 3 ] ] -RRB- cord-302953-gr2kk9w4 336 4 [ [ -LRB- cord-302953-gr2kk9w4 336 5 69 69 CD cord-302953-gr2kk9w4 336 6 ] ] -RRB- cord-302953-gr2kk9w4 336 7 [ [ -LRB- cord-302953-gr2kk9w4 336 8 70 70 CD cord-302953-gr2kk9w4 336 9 ] ] -RRB- cord-302953-gr2kk9w4 336 10 , , , cord-302953-gr2kk9w4 336 11 but but CC cord-302953-gr2kk9w4 336 12 CD8 CD8 NNP cord-302953-gr2kk9w4 336 13 + + CC cord-302953-gr2kk9w4 336 14 T T NNP cord-302953-gr2kk9w4 336 15 cells cell NNS cord-302953-gr2kk9w4 336 16 can can MD cord-302953-gr2kk9w4 336 17 directly directly RB cord-302953-gr2kk9w4 336 18 engage engage VB cord-302953-gr2kk9w4 336 19 virus virus NN cord-302953-gr2kk9w4 336 20 - - HYPH cord-302953-gr2kk9w4 336 21 infected infect VBN cord-302953-gr2kk9w4 336 22 neurons neuron NNS cord-302953-gr2kk9w4 336 23 [ [ -LRB- cord-302953-gr2kk9w4 336 24 71 71 CD cord-302953-gr2kk9w4 336 25 ] ] -RRB- cord-302953-gr2kk9w4 336 26 , , , cord-302953-gr2kk9w4 336 27 and and CC cord-302953-gr2kk9w4 336 28 clearance clearance NN cord-302953-gr2kk9w4 336 29 of of IN cord-302953-gr2kk9w4 336 30 WNV WNV NNP cord-302953-gr2kk9w4 336 31 , , , cord-302953-gr2kk9w4 336 32 JEV JEV NNP cord-302953-gr2kk9w4 336 33 , , , cord-302953-gr2kk9w4 336 34 and and CC cord-302953-gr2kk9w4 336 35 LCMV LCMV NNP cord-302953-gr2kk9w4 336 36 from from IN cord-302953-gr2kk9w4 336 37 the the DT cord-302953-gr2kk9w4 336 38 CNS CNS NNP cord-302953-gr2kk9w4 336 39 is be VBZ cord-302953-gr2kk9w4 336 40 dependent dependent JJ cord-302953-gr2kk9w4 336 41 on on IN cord-302953-gr2kk9w4 336 42 the the DT cord-302953-gr2kk9w4 336 43 granzyme granzyme NNS cord-302953-gr2kk9w4 336 44 / / SYM cord-302953-gr2kk9w4 336 45 perforin perforin NNP cord-302953-gr2kk9w4 336 46 pathway pathway NN cord-302953-gr2kk9w4 336 47 [ [ -LRB- cord-302953-gr2kk9w4 336 48 72 72 CD cord-302953-gr2kk9w4 336 49 ] ] -RRB- cord-302953-gr2kk9w4 337 1 [ [ -LRB- cord-302953-gr2kk9w4 337 2 73 73 CD cord-302953-gr2kk9w4 337 3 ] ] -RRB- cord-302953-gr2kk9w4 337 4 [ [ -LRB- cord-302953-gr2kk9w4 337 5 74 74 CD cord-302953-gr2kk9w4 337 6 ] ] -RRB- cord-302953-gr2kk9w4 337 7 . . . cord-302953-gr2kk9w4 338 1 Perforin perforin JJ cord-302953-gr2kk9w4 338 2 production production NN cord-302953-gr2kk9w4 338 3 is be VBZ cord-302953-gr2kk9w4 338 4 decreased decrease VBN cord-302953-gr2kk9w4 338 5 in in IN cord-302953-gr2kk9w4 338 6 the the DT cord-302953-gr2kk9w4 338 7 brains brain NNS cord-302953-gr2kk9w4 338 8 of of IN cord-302953-gr2kk9w4 338 9 WT WT NNP cord-302953-gr2kk9w4 338 10 mice mouse NNS cord-302953-gr2kk9w4 338 11 compared compare VBN cord-302953-gr2kk9w4 338 12 to to IN cord-302953-gr2kk9w4 338 13 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 338 14 −/− −/− NNP cord-302953-gr2kk9w4 338 15 and and CC cord-302953-gr2kk9w4 338 16 Ifng Ifng NNP cord-302953-gr2kk9w4 338 17 −/− −/− NNP cord-302953-gr2kk9w4 338 18 mice mouse NNS cord-302953-gr2kk9w4 338 19 during during IN cord-302953-gr2kk9w4 338 20 SINV SINV NNP cord-302953-gr2kk9w4 338 21 NSV NSV NNP cord-302953-gr2kk9w4 338 22 infection infection NN cord-302953-gr2kk9w4 338 23 [ [ -LRB- cord-302953-gr2kk9w4 338 24 30 30 CD cord-302953-gr2kk9w4 338 25 ] ] -RRB- cord-302953-gr2kk9w4 338 26 , , , cord-302953-gr2kk9w4 338 27 and and CC cord-302953-gr2kk9w4 338 28 perforin perforin NNP cord-302953-gr2kk9w4 338 29 - - HYPH cord-302953-gr2kk9w4 338 30 mediated mediate VBN cord-302953-gr2kk9w4 338 31 effector effector NN cord-302953-gr2kk9w4 338 32 function function NN cord-302953-gr2kk9w4 338 33 is be VBZ cord-302953-gr2kk9w4 338 34 impaired impair VBN cord-302953-gr2kk9w4 338 35 during during IN cord-302953-gr2kk9w4 338 36 JHMV JHMV NNP cord-302953-gr2kk9w4 338 37 infection infection NN cord-302953-gr2kk9w4 338 38 [ [ -LRB- cord-302953-gr2kk9w4 338 39 75 75 CD cord-302953-gr2kk9w4 338 40 ] ] -RRB- cord-302953-gr2kk9w4 339 1 However however RB cord-302953-gr2kk9w4 339 2 , , , cord-302953-gr2kk9w4 339 3 IFN IFN NNP cord-302953-gr2kk9w4 339 4 - - HYPH cord-302953-gr2kk9w4 339 5 γ γ NNP cord-302953-gr2kk9w4 339 6 promotes promote VBZ cord-302953-gr2kk9w4 339 7 granzyme granzyme NNS cord-302953-gr2kk9w4 339 8 B B NNP cord-302953-gr2kk9w4 339 9 production production NN cord-302953-gr2kk9w4 339 10 during during IN cord-302953-gr2kk9w4 339 11 experimental experimental JJ cord-302953-gr2kk9w4 339 12 coronavirus coronavirus NN cord-302953-gr2kk9w4 339 13 retinopathy retinopathy NN cord-302953-gr2kk9w4 339 14 [ [ -LRB- cord-302953-gr2kk9w4 339 15 76 76 CD cord-302953-gr2kk9w4 339 16 ] ] -RRB- cord-302953-gr2kk9w4 339 17 . . . cord-302953-gr2kk9w4 340 1 Therefore therefore RB cord-302953-gr2kk9w4 340 2 , , , cord-302953-gr2kk9w4 340 3 the the DT cord-302953-gr2kk9w4 340 4 effect effect NN cord-302953-gr2kk9w4 340 5 of of IN cord-302953-gr2kk9w4 340 6 IFN IFN NNP cord-302953-gr2kk9w4 340 7 - - HYPH cord-302953-gr2kk9w4 340 8 γ γ NNP cord-302953-gr2kk9w4 340 9 on on IN cord-302953-gr2kk9w4 340 10 the the DT cord-302953-gr2kk9w4 340 11 granule granule NN cord-302953-gr2kk9w4 340 12 exocytosis exocytosis NN cord-302953-gr2kk9w4 340 13 pathway pathway NN cord-302953-gr2kk9w4 340 14 during during IN cord-302953-gr2kk9w4 340 15 CNS CNS NNP cord-302953-gr2kk9w4 340 16 infection infection NN cord-302953-gr2kk9w4 340 17 appears appear VBZ cord-302953-gr2kk9w4 340 18 to to TO cord-302953-gr2kk9w4 340 19 be be VB cord-302953-gr2kk9w4 340 20 virus virus NN cord-302953-gr2kk9w4 340 21 - - HYPH cord-302953-gr2kk9w4 340 22 specific specific JJ cord-302953-gr2kk9w4 340 23 , , , cord-302953-gr2kk9w4 340 24 and and CC cord-302953-gr2kk9w4 340 25 the the DT cord-302953-gr2kk9w4 340 26 mechanisms mechanism NNS cord-302953-gr2kk9w4 340 27 by by IN cord-302953-gr2kk9w4 340 28 which which WDT cord-302953-gr2kk9w4 340 29 IFN IFN NNP cord-302953-gr2kk9w4 340 30 - - HYPH cord-302953-gr2kk9w4 340 31 γ γ NNP cord-302953-gr2kk9w4 340 32 influences influence VBZ cord-302953-gr2kk9w4 340 33 granzyme granzyme VBZ cord-302953-gr2kk9w4 340 34 production production NN cord-302953-gr2kk9w4 340 35 during during IN cord-302953-gr2kk9w4 340 36 SINV SINV NNP cord-302953-gr2kk9w4 340 37 infection infection NN cord-302953-gr2kk9w4 340 38 remain remain VBP cord-302953-gr2kk9w4 340 39 to to TO cord-302953-gr2kk9w4 340 40 be be VB cord-302953-gr2kk9w4 340 41 understood understand VBN cord-302953-gr2kk9w4 340 42 . . . cord-302953-gr2kk9w4 341 1 It -PRON- PRP cord-302953-gr2kk9w4 341 2 is be VBZ cord-302953-gr2kk9w4 341 3 becoming become VBG cord-302953-gr2kk9w4 341 4 increasingly increasingly RB cord-302953-gr2kk9w4 341 5 understood understand VBN cord-302953-gr2kk9w4 341 6 that that IN cord-302953-gr2kk9w4 341 7 granzymes granzyme NNS cord-302953-gr2kk9w4 341 8 have have VBP cord-302953-gr2kk9w4 341 9 non non JJ cord-302953-gr2kk9w4 341 10 - - JJ cord-302953-gr2kk9w4 341 11 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 341 12 as as RB cord-302953-gr2kk9w4 341 13 well well RB cord-302953-gr2kk9w4 341 14 as as IN cord-302953-gr2kk9w4 341 15 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 341 16 roles role NNS cord-302953-gr2kk9w4 341 17 [ [ -LRB- cord-302953-gr2kk9w4 341 18 36 36 CD cord-302953-gr2kk9w4 341 19 , , , cord-302953-gr2kk9w4 341 20 [ [ -LRB- cord-302953-gr2kk9w4 341 21 77 77 CD cord-302953-gr2kk9w4 341 22 ] ] -RRB- cord-302953-gr2kk9w4 341 23 [ [ -LRB- cord-302953-gr2kk9w4 341 24 78 78 CD cord-302953-gr2kk9w4 341 25 ] ] -RRB- cord-302953-gr2kk9w4 341 26 [ [ -LRB- cord-302953-gr2kk9w4 341 27 79 79 CD cord-302953-gr2kk9w4 341 28 ] ] -RRB- cord-302953-gr2kk9w4 341 29 . . . cord-302953-gr2kk9w4 342 1 For for IN cord-302953-gr2kk9w4 342 2 instance instance NN cord-302953-gr2kk9w4 342 3 , , , cord-302953-gr2kk9w4 342 4 CD8 CD8 NNP cord-302953-gr2kk9w4 342 5 + + CC cord-302953-gr2kk9w4 342 6 T T NNP cord-302953-gr2kk9w4 342 7 cells cell NNS cord-302953-gr2kk9w4 342 8 can can MD cord-302953-gr2kk9w4 342 9 inhibit inhibit VB cord-302953-gr2kk9w4 342 10 reactivation reactivation NN cord-302953-gr2kk9w4 342 11 of of IN cord-302953-gr2kk9w4 342 12 HSV-1 hsv-1 NN cord-302953-gr2kk9w4 342 13 in in IN cord-302953-gr2kk9w4 342 14 neurons neuron NNS cord-302953-gr2kk9w4 342 15 via via IN cord-302953-gr2kk9w4 342 16 a a DT cord-302953-gr2kk9w4 342 17 non non JJ cord-302953-gr2kk9w4 342 18 - - JJ cord-302953-gr2kk9w4 342 19 cytolytic cytolytic JJ cord-302953-gr2kk9w4 342 20 mechanism mechanism NN cord-302953-gr2kk9w4 342 21 [ [ -LRB- cord-302953-gr2kk9w4 342 22 80 80 CD cord-302953-gr2kk9w4 342 23 ] ] -RRB- cord-302953-gr2kk9w4 343 1 [ [ -LRB- cord-302953-gr2kk9w4 343 2 81 81 CD cord-302953-gr2kk9w4 343 3 ] ] -RRB- cord-302953-gr2kk9w4 343 4 [ [ -LRB- cord-302953-gr2kk9w4 343 5 82 82 CD cord-302953-gr2kk9w4 343 6 ] ] -RRB- cord-302953-gr2kk9w4 343 7 . . . cord-302953-gr2kk9w4 344 1 Mouse Mouse NNP cord-302953-gr2kk9w4 344 2 granzyme granzyme NNS cord-302953-gr2kk9w4 345 1 K K NNP cord-302953-gr2kk9w4 345 2 induces induce VBZ cord-302953-gr2kk9w4 345 3 macrophages macrophage NNS cord-302953-gr2kk9w4 345 4 to to TO cord-302953-gr2kk9w4 345 5 release release VB cord-302953-gr2kk9w4 345 6 IL-1β IL-1β NNP cord-302953-gr2kk9w4 345 7 during during IN cord-302953-gr2kk9w4 345 8 LCMV LCMV NNP cord-302953-gr2kk9w4 345 9 infection infection NN cord-302953-gr2kk9w4 345 10 [ [ -LRB- cord-302953-gr2kk9w4 345 11 83 83 CD cord-302953-gr2kk9w4 345 12 ] ] -RRB- cord-302953-gr2kk9w4 345 13 , , , cord-302953-gr2kk9w4 345 14 and and CC cord-302953-gr2kk9w4 345 15 granzyme granzyme NNS cord-302953-gr2kk9w4 345 16 substrates substrate NNS cord-302953-gr2kk9w4 345 17 with with IN cord-302953-gr2kk9w4 345 18 direct direct JJ cord-302953-gr2kk9w4 345 19 antiviral antiviral JJ cord-302953-gr2kk9w4 345 20 activity activity NN cord-302953-gr2kk9w4 345 21 , , , cord-302953-gr2kk9w4 345 22 either either CC cord-302953-gr2kk9w4 345 23 viral viral JJ cord-302953-gr2kk9w4 345 24 proteins protein NNS cord-302953-gr2kk9w4 345 25 or or CC cord-302953-gr2kk9w4 345 26 host host NN cord-302953-gr2kk9w4 345 27 cell cell NN cord-302953-gr2kk9w4 345 28 proteins protein NNS cord-302953-gr2kk9w4 345 29 essential essential JJ cord-302953-gr2kk9w4 345 30 for for IN cord-302953-gr2kk9w4 345 31 virus virus NN cord-302953-gr2kk9w4 345 32 replication replication NN cord-302953-gr2kk9w4 345 33 , , , cord-302953-gr2kk9w4 345 34 have have VBP cord-302953-gr2kk9w4 345 35 also also RB cord-302953-gr2kk9w4 345 36 been be VBN cord-302953-gr2kk9w4 345 37 identified identify VBN cord-302953-gr2kk9w4 345 38 . . . cord-302953-gr2kk9w4 346 1 Granzymes Granzymes NNP cord-302953-gr2kk9w4 346 2 A A NNP cord-302953-gr2kk9w4 346 3 , , , cord-302953-gr2kk9w4 346 4 H H NNP cord-302953-gr2kk9w4 346 5 , , , cord-302953-gr2kk9w4 346 6 and and CC cord-302953-gr2kk9w4 346 7 M M NNP cord-302953-gr2kk9w4 346 8 cleave cleave VBP cord-302953-gr2kk9w4 346 9 viral viral JJ cord-302953-gr2kk9w4 346 10 proteins protein NNS cord-302953-gr2kk9w4 346 11 important important JJ cord-302953-gr2kk9w4 346 12 for for IN cord-302953-gr2kk9w4 346 13 replication replication NN cord-302953-gr2kk9w4 346 14 of of IN cord-302953-gr2kk9w4 346 15 Moloney Moloney NNP cord-302953-gr2kk9w4 346 16 mouse mouse NN cord-302953-gr2kk9w4 346 17 leukemia leukemia NN cord-302953-gr2kk9w4 346 18 virus virus NN cord-302953-gr2kk9w4 346 19 , , , cord-302953-gr2kk9w4 346 20 adenovirus adenovirus NN cord-302953-gr2kk9w4 346 21 , , , cord-302953-gr2kk9w4 346 22 and and CC cord-302953-gr2kk9w4 346 23 human human JJ cord-302953-gr2kk9w4 346 24 cytomegalovirus cytomegalovirus NN cord-302953-gr2kk9w4 346 25 [ [ -LRB- cord-302953-gr2kk9w4 346 26 84 84 CD cord-302953-gr2kk9w4 346 27 ] ] -RRB- cord-302953-gr2kk9w4 346 28 [ [ -LRB- cord-302953-gr2kk9w4 346 29 85 85 CD cord-302953-gr2kk9w4 346 30 ] ] -RRB- cord-302953-gr2kk9w4 346 31 [ [ -LRB- cord-302953-gr2kk9w4 346 32 86 86 CD cord-302953-gr2kk9w4 346 33 ] ] -RRB- cord-302953-gr2kk9w4 346 34 . . . cord-302953-gr2kk9w4 347 1 Granzymes Granzymes NNP cord-302953-gr2kk9w4 347 2 B B NNP cord-302953-gr2kk9w4 347 3 and and CC cord-302953-gr2kk9w4 347 4 H H NNP cord-302953-gr2kk9w4 347 5 both both DT cord-302953-gr2kk9w4 347 6 cleave cleave VBP cord-302953-gr2kk9w4 347 7 the the DT cord-302953-gr2kk9w4 347 8 RNA RNA NNP cord-302953-gr2kk9w4 347 9 - - HYPH cord-302953-gr2kk9w4 347 10 binding bind VBG cord-302953-gr2kk9w4 347 11 protein protein NN cord-302953-gr2kk9w4 347 12 La La NNP cord-302953-gr2kk9w4 347 13 , , , cord-302953-gr2kk9w4 347 14 which which WDT cord-302953-gr2kk9w4 347 15 is be VBZ cord-302953-gr2kk9w4 347 16 important important JJ cord-302953-gr2kk9w4 347 17 in in IN cord-302953-gr2kk9w4 347 18 viral viral JJ cord-302953-gr2kk9w4 347 19 RNA RNA NNP cord-302953-gr2kk9w4 347 20 metabolism metabolism NN cord-302953-gr2kk9w4 347 21 for for IN cord-302953-gr2kk9w4 347 22 several several JJ cord-302953-gr2kk9w4 347 23 viruses virus NNS cord-302953-gr2kk9w4 347 24 [ [ -LRB- cord-302953-gr2kk9w4 347 25 87 87 CD cord-302953-gr2kk9w4 347 26 ] ] -RRB- cord-302953-gr2kk9w4 347 27 [ [ -LRB- cord-302953-gr2kk9w4 347 28 88 88 CD cord-302953-gr2kk9w4 347 29 ] ] -RRB- cord-302953-gr2kk9w4 348 1 [ [ -LRB- cord-302953-gr2kk9w4 348 2 89 89 CD cord-302953-gr2kk9w4 348 3 ] ] -RRB- cord-302953-gr2kk9w4 348 4 [ [ -LRB- cord-302953-gr2kk9w4 348 5 90 90 CD cord-302953-gr2kk9w4 348 6 ] ] -RRB- cord-302953-gr2kk9w4 348 7 . . . cord-302953-gr2kk9w4 349 1 hnRNP hnrnp DT cord-302953-gr2kk9w4 350 1 K K NNP cord-302953-gr2kk9w4 350 2 , , , cord-302953-gr2kk9w4 350 3 which which WDT cord-302953-gr2kk9w4 350 4 modulates modulate VBZ cord-302953-gr2kk9w4 350 5 viral viral JJ cord-302953-gr2kk9w4 350 6 RNA RNA NNP cord-302953-gr2kk9w4 350 7 replication replication NN cord-302953-gr2kk9w4 350 8 of of IN cord-302953-gr2kk9w4 350 9 CHIKV CHIKV NNP cord-302953-gr2kk9w4 350 10 , , , cord-302953-gr2kk9w4 350 11 enterovirus enterovirus NN cord-302953-gr2kk9w4 350 12 71 71 CD cord-302953-gr2kk9w4 350 13 , , , cord-302953-gr2kk9w4 350 14 dengue dengue NN cord-302953-gr2kk9w4 350 15 virus virus NN cord-302953-gr2kk9w4 350 16 , , , cord-302953-gr2kk9w4 350 17 and and CC cord-302953-gr2kk9w4 350 18 HIV-1 HIV-1 NNP cord-302953-gr2kk9w4 350 19 [ [ -LRB- cord-302953-gr2kk9w4 350 20 91 91 CD cord-302953-gr2kk9w4 350 21 ] ] -RRB- cord-302953-gr2kk9w4 350 22 [ [ -LRB- cord-302953-gr2kk9w4 350 23 92 92 CD cord-302953-gr2kk9w4 350 24 ] ] -RRB- cord-302953-gr2kk9w4 350 25 [ [ -LRB- cord-302953-gr2kk9w4 350 26 93 93 CD cord-302953-gr2kk9w4 350 27 ] ] -RRB- cord-302953-gr2kk9w4 350 28 [ [ -LRB- cord-302953-gr2kk9w4 350 29 94 94 CD cord-302953-gr2kk9w4 350 30 ] ] -RRB- cord-302953-gr2kk9w4 350 31 and and CC cord-302953-gr2kk9w4 350 32 interacts interact VBZ cord-302953-gr2kk9w4 350 33 with with IN cord-302953-gr2kk9w4 350 34 SINV SINV NNP cord-302953-gr2kk9w4 350 35 nsp2 nsp2 NNP cord-302953-gr2kk9w4 350 36 and and CC cord-302953-gr2kk9w4 350 37 subgenomic subgenomic NNP cord-302953-gr2kk9w4 351 1 mRNA mRNA NNP cord-302953-gr2kk9w4 351 2 [ [ -LRB- cord-302953-gr2kk9w4 351 3 95 95 CD cord-302953-gr2kk9w4 351 4 , , , cord-302953-gr2kk9w4 351 5 96 96 CD cord-302953-gr2kk9w4 351 6 ] ] -RRB- cord-302953-gr2kk9w4 351 7 , , , cord-302953-gr2kk9w4 351 8 is be VBZ cord-302953-gr2kk9w4 351 9 a a DT cord-302953-gr2kk9w4 351 10 substrate substrate NN cord-302953-gr2kk9w4 351 11 for for IN cord-302953-gr2kk9w4 351 12 granzyme granzyme NNS cord-302953-gr2kk9w4 351 13 B. B. NNP cord-302953-gr2kk9w4 351 14 Silencing Silencing NNP cord-302953-gr2kk9w4 351 15 of of IN cord-302953-gr2kk9w4 351 16 hnRNP hnrnp DT cord-302953-gr2kk9w4 352 1 K K NNP cord-302953-gr2kk9w4 352 2 or or CC cord-302953-gr2kk9w4 352 3 disruption disruption NN cord-302953-gr2kk9w4 352 4 of of IN cord-302953-gr2kk9w4 352 5 hnRNP hnrnp RB cord-302953-gr2kk9w4 352 6 - - HYPH cord-302953-gr2kk9w4 352 7 vRNA vrna JJ cord-302953-gr2kk9w4 352 8 binding binding NN cord-302953-gr2kk9w4 352 9 decreases decrease VBZ cord-302953-gr2kk9w4 352 10 SINV SINV NNP cord-302953-gr2kk9w4 352 11 RNA RNA NNP cord-302953-gr2kk9w4 352 12 replication replication NN cord-302953-gr2kk9w4 352 13 in in IN cord-302953-gr2kk9w4 352 14 vitro vitro FW cord-302953-gr2kk9w4 352 15 [ [ -LRB- cord-302953-gr2kk9w4 352 16 96 96 CD cord-302953-gr2kk9w4 352 17 , , , cord-302953-gr2kk9w4 352 18 97 97 CD cord-302953-gr2kk9w4 352 19 ] ] -RRB- cord-302953-gr2kk9w4 352 20 . . . cord-302953-gr2kk9w4 353 1 Therefore therefore RB cord-302953-gr2kk9w4 353 2 , , , cord-302953-gr2kk9w4 353 3 we -PRON- PRP cord-302953-gr2kk9w4 353 4 postulate postulate VBP cord-302953-gr2kk9w4 353 5 that that IN cord-302953-gr2kk9w4 353 6 the the DT cord-302953-gr2kk9w4 353 7 increased increase VBN cord-302953-gr2kk9w4 353 8 granzyme granzyme NNS cord-302953-gr2kk9w4 353 9 B B NNP cord-302953-gr2kk9w4 353 10 produced produce VBN cord-302953-gr2kk9w4 353 11 by by IN cord-302953-gr2kk9w4 353 12 CD8 CD8 NNP cord-302953-gr2kk9w4 353 13 + + CC cord-302953-gr2kk9w4 353 14 T T NNP cord-302953-gr2kk9w4 353 15 cells cell NNS cord-302953-gr2kk9w4 353 16 of of IN cord-302953-gr2kk9w4 353 17 Ifngr1 Ifngr1 NNP cord-302953-gr2kk9w4 353 18 −/− −/− NNP cord-302953-gr2kk9w4 354 1 and and CC cord-302953-gr2kk9w4 354 2 Ifng Ifng NNP cord-302953-gr2kk9w4 354 3 −/− −/− NNP cord-302953-gr2kk9w4 354 4 cleaves cleave VBZ cord-302953-gr2kk9w4 354 5 one one CD cord-302953-gr2kk9w4 354 6 or or CC cord-302953-gr2kk9w4 354 7 more more JJR cord-302953-gr2kk9w4 354 8 cellular cellular JJ cord-302953-gr2kk9w4 354 9 proteins protein NNS cord-302953-gr2kk9w4 354 10 important important JJ cord-302953-gr2kk9w4 354 11 for for IN cord-302953-gr2kk9w4 354 12 SINV SINV NNP cord-302953-gr2kk9w4 354 13 RNA RNA NNP cord-302953-gr2kk9w4 354 14 replication replication NN cord-302953-gr2kk9w4 354 15 or or CC cord-302953-gr2kk9w4 354 16 stability stability NN cord-302953-gr2kk9w4 354 17 to to TO cord-302953-gr2kk9w4 354 18 accelerate accelerate VB cord-302953-gr2kk9w4 354 19 noncytotoxic noncytotoxic NNP cord-302953-gr2kk9w4 354 20 viral viral JJ cord-302953-gr2kk9w4 354 21 RNA RNA NNP cord-302953-gr2kk9w4 354 22 clearance clearance NN cord-302953-gr2kk9w4 354 23 from from IN cord-302953-gr2kk9w4 354 24 the the DT cord-302953-gr2kk9w4 354 25 brain brain NN cord-302953-gr2kk9w4 354 26 and and CC cord-302953-gr2kk9w4 354 27 spinal spinal JJ cord-302953-gr2kk9w4 354 28 cord cord NN cord-302953-gr2kk9w4 354 29 . . . cord-302953-gr2kk9w4 355 1 Further further JJ cord-302953-gr2kk9w4 355 2 studies study NNS cord-302953-gr2kk9w4 355 3 regarding regard VBG cord-302953-gr2kk9w4 355 4 viral viral JJ cord-302953-gr2kk9w4 355 5 RNA RNA NNP cord-302953-gr2kk9w4 355 6 clearance clearance NN cord-302953-gr2kk9w4 355 7 , , , cord-302953-gr2kk9w4 355 8 the the DT cord-302953-gr2kk9w4 355 9 noncytotoxic noncytotoxic NNP cord-302953-gr2kk9w4 355 10 roles role NNS cord-302953-gr2kk9w4 355 11 of of IN cord-302953-gr2kk9w4 355 12 granzymes granzyme NNS cord-302953-gr2kk9w4 355 13 during during IN cord-302953-gr2kk9w4 355 14 SINV SINV NNP cord-302953-gr2kk9w4 355 15 infection infection NN cord-302953-gr2kk9w4 355 16 , , , cord-302953-gr2kk9w4 355 17 and and CC cord-302953-gr2kk9w4 355 18 regulation regulation NN cord-302953-gr2kk9w4 355 19 by by IN cord-302953-gr2kk9w4 355 20 IFN IFN NNP cord-302953-gr2kk9w4 355 21 - - HYPH cord-302953-gr2kk9w4 355 22 γ γ NNP cord-302953-gr2kk9w4 355 23 , , , cord-302953-gr2kk9w4 355 24 are be VBP cord-302953-gr2kk9w4 355 25 warranted warrant VBN cord-302953-gr2kk9w4 355 26 . . . cord-302953-gr2kk9w4 356 1 Persistence persistence NN cord-302953-gr2kk9w4 356 2 of of IN cord-302953-gr2kk9w4 356 3 viral viral JJ cord-302953-gr2kk9w4 356 4 RNA rna NN cord-302953-gr2kk9w4 356 5 after after IN cord-302953-gr2kk9w4 356 6 CNS CNS NNP cord-302953-gr2kk9w4 356 7 infection infection NN cord-302953-gr2kk9w4 356 8 is be VBZ cord-302953-gr2kk9w4 356 9 common common JJ cord-302953-gr2kk9w4 356 10 [ [ -LRB- cord-302953-gr2kk9w4 356 11 5 5 CD cord-302953-gr2kk9w4 356 12 , , , cord-302953-gr2kk9w4 356 13 10 10 CD cord-302953-gr2kk9w4 356 14 , , , cord-302953-gr2kk9w4 356 15 [ [ -LRB- cord-302953-gr2kk9w4 356 16 98 98 CD cord-302953-gr2kk9w4 356 17 ] ] -RRB- cord-302953-gr2kk9w4 356 18 [ [ -LRB- cord-302953-gr2kk9w4 356 19 99 99 CD cord-302953-gr2kk9w4 356 20 ] ] -RRB- cord-302953-gr2kk9w4 356 21 [ [ -LRB- cord-302953-gr2kk9w4 356 22 100 100 CD cord-302953-gr2kk9w4 356 23 ] ] -RRB- cord-302953-gr2kk9w4 356 24 [ [ -LRB- cord-302953-gr2kk9w4 356 25 101 101 CD cord-302953-gr2kk9w4 356 26 ] ] -RRB- cord-302953-gr2kk9w4 356 27 [ [ -LRB- cord-302953-gr2kk9w4 356 28 102 102 CD cord-302953-gr2kk9w4 356 29 ] ] -RRB- cord-302953-gr2kk9w4 356 30 and and CC cord-302953-gr2kk9w4 356 31 presents present VBZ cord-302953-gr2kk9w4 356 32 the the DT cord-302953-gr2kk9w4 356 33 potential potential NN cord-302953-gr2kk9w4 356 34 for for IN cord-302953-gr2kk9w4 356 35 virus virus NN cord-302953-gr2kk9w4 356 36 reactivation reactivation NN cord-302953-gr2kk9w4 356 37 and and CC cord-302953-gr2kk9w4 356 38 relapse relapse NN cord-302953-gr2kk9w4 356 39 of of IN cord-302953-gr2kk9w4 356 40 disease disease NN cord-302953-gr2kk9w4 356 41 . . . cord-302953-gr2kk9w4 357 1 Indeed indeed RB cord-302953-gr2kk9w4 357 2 , , , cord-302953-gr2kk9w4 357 3 during during IN cord-302953-gr2kk9w4 357 4 Phase phase NN cord-302953-gr2kk9w4 357 5 3 3 CD cord-302953-gr2kk9w4 357 6 of of IN cord-302953-gr2kk9w4 357 7 infection infection NN cord-302953-gr2kk9w4 357 8 , , , cord-302953-gr2kk9w4 357 9 transient transient JJ cord-302953-gr2kk9w4 357 10 increases increase NNS cord-302953-gr2kk9w4 357 11 in in IN cord-302953-gr2kk9w4 357 12 viral viral JJ cord-302953-gr2kk9w4 357 13 RNA RNA NNP cord-302953-gr2kk9w4 357 14 were be VBD cord-302953-gr2kk9w4 357 15 seen see VBN cord-302953-gr2kk9w4 357 16 in in IN cord-302953-gr2kk9w4 357 17 SINV SINV NNP cord-302953-gr2kk9w4 357 18 - - HYPH cord-302953-gr2kk9w4 357 19 infected infect VBN cord-302953-gr2kk9w4 357 20 mice mouse NNS cord-302953-gr2kk9w4 357 21 , , , cord-302953-gr2kk9w4 357 22 particularly particularly RB cord-302953-gr2kk9w4 357 23 in in IN cord-302953-gr2kk9w4 358 1 Ifng Ifng NNP cord-302953-gr2kk9w4 358 2 −/− −/− NNP cord-302953-gr2kk9w4 358 3 mice mouse NNS cord-302953-gr2kk9w4 358 4 . . . cord-302953-gr2kk9w4 359 1 Therefore therefore RB cord-302953-gr2kk9w4 359 2 , , , cord-302953-gr2kk9w4 359 3 prevention prevention NN cord-302953-gr2kk9w4 359 4 of of IN cord-302953-gr2kk9w4 359 5 virus virus NN cord-302953-gr2kk9w4 359 6 reactivation reactivation NN cord-302953-gr2kk9w4 359 7 is be VBZ cord-302953-gr2kk9w4 359 8 likely likely RB cord-302953-gr2kk9w4 359 9 achieved achieve VBN cord-302953-gr2kk9w4 359 10 through through IN cord-302953-gr2kk9w4 359 11 continued continue VBN cord-302953-gr2kk9w4 359 12 presence presence NN cord-302953-gr2kk9w4 359 13 of of IN cord-302953-gr2kk9w4 359 14 immune immune JJ cord-302953-gr2kk9w4 359 15 cells cell NNS cord-302953-gr2kk9w4 359 16 at at IN cord-302953-gr2kk9w4 359 17 the the DT cord-302953-gr2kk9w4 359 18 previous previous JJ cord-302953-gr2kk9w4 359 19 site site NN cord-302953-gr2kk9w4 359 20 of of IN cord-302953-gr2kk9w4 359 21 infection infection NN cord-302953-gr2kk9w4 359 22 [ [ -LRB- cord-302953-gr2kk9w4 359 23 103 103 CD cord-302953-gr2kk9w4 359 24 , , , cord-302953-gr2kk9w4 359 25 104 104 CD cord-302953-gr2kk9w4 359 26 ] ] -RRB- cord-302953-gr2kk9w4 359 27 . . . cord-302953-gr2kk9w4 360 1 Over over IN cord-302953-gr2kk9w4 360 2 the the DT cord-302953-gr2kk9w4 360 3 course course NN cord-302953-gr2kk9w4 360 4 of of IN cord-302953-gr2kk9w4 360 5 infection infection NN cord-302953-gr2kk9w4 360 6 , , , cord-302953-gr2kk9w4 360 7 the the DT cord-302953-gr2kk9w4 360 8 percentage percentage NN cord-302953-gr2kk9w4 360 9 of of IN cord-302953-gr2kk9w4 360 10 CD8 CD8 NNP cord-302953-gr2kk9w4 360 11 + + CC cord-302953-gr2kk9w4 360 12 , , , cord-302953-gr2kk9w4 360 13 but but CC cord-302953-gr2kk9w4 360 14 not not RB cord-302953-gr2kk9w4 360 15 CD4 CD4 NNP cord-302953-gr2kk9w4 360 16 + + XX cord-302953-gr2kk9w4 360 17 , , , cord-302953-gr2kk9w4 360 18 T t NN cord-302953-gr2kk9w4 360 19 cells cell NNS cord-302953-gr2kk9w4 360 20 expressing express VBG cord-302953-gr2kk9w4 360 21 CD103 CD103 NNP cord-302953-gr2kk9w4 360 22 , , , cord-302953-gr2kk9w4 360 23 a a DT cord-302953-gr2kk9w4 360 24 marker marker NN cord-302953-gr2kk9w4 360 25 for for IN cord-302953-gr2kk9w4 360 26 T T NNP cord-302953-gr2kk9w4 360 27 RM RM NNP cord-302953-gr2kk9w4 360 28 cells cell NNS cord-302953-gr2kk9w4 360 29 in in IN cord-302953-gr2kk9w4 360 30 the the DT cord-302953-gr2kk9w4 360 31 brain brain NN cord-302953-gr2kk9w4 360 32 , , , cord-302953-gr2kk9w4 360 33 increased increase VBD cord-302953-gr2kk9w4 360 34 . . . cord-302953-gr2kk9w4 361 1 As as IN cord-302953-gr2kk9w4 361 2 permanent permanent JJ cord-302953-gr2kk9w4 361 3 residents resident NNS cord-302953-gr2kk9w4 361 4 at at IN cord-302953-gr2kk9w4 361 5 sites site NNS cord-302953-gr2kk9w4 361 6 of of IN cord-302953-gr2kk9w4 361 7 previous previous JJ cord-302953-gr2kk9w4 361 8 infection infection NN cord-302953-gr2kk9w4 361 9 , , , cord-302953-gr2kk9w4 361 10 T T NNP cord-302953-gr2kk9w4 361 11 RM RM NNP cord-302953-gr2kk9w4 361 12 cells cell NNS cord-302953-gr2kk9w4 361 13 provide provide VBP cord-302953-gr2kk9w4 361 14 a a DT cord-302953-gr2kk9w4 361 15 rapid rapid JJ cord-302953-gr2kk9w4 361 16 response response NN cord-302953-gr2kk9w4 361 17 to to IN cord-302953-gr2kk9w4 361 18 pathogen pathogen NN cord-302953-gr2kk9w4 361 19 reactivation reactivation NN cord-302953-gr2kk9w4 361 20 [ [ -LRB- cord-302953-gr2kk9w4 361 21 105 105 CD cord-302953-gr2kk9w4 361 22 ] ] -RRB- cord-302953-gr2kk9w4 361 23 [ [ -LRB- cord-302953-gr2kk9w4 361 24 106 106 CD cord-302953-gr2kk9w4 361 25 ] ] -RRB- cord-302953-gr2kk9w4 361 26 [ [ -LRB- cord-302953-gr2kk9w4 361 27 107 107 CD cord-302953-gr2kk9w4 361 28 ] ] -RRB- cord-302953-gr2kk9w4 361 29 . . . cord-302953-gr2kk9w4 362 1 IFN IFN NNP cord-302953-gr2kk9w4 362 2 - - HYPH cord-302953-gr2kk9w4 362 3 γ γ NNP cord-302953-gr2kk9w4 362 4 produced produce VBN cord-302953-gr2kk9w4 362 5 by by IN cord-302953-gr2kk9w4 362 6 CD4 CD4 NNP cord-302953-gr2kk9w4 362 7 + + CC cord-302953-gr2kk9w4 362 8 T T NNP cord-302953-gr2kk9w4 362 9 cells cell NNS cord-302953-gr2kk9w4 362 10 is be VBZ cord-302953-gr2kk9w4 362 11 required require VBN cord-302953-gr2kk9w4 362 12 for for IN cord-302953-gr2kk9w4 362 13 generating generate VBG cord-302953-gr2kk9w4 362 14 CD8 CD8 NNP cord-302953-gr2kk9w4 362 15 + + CC cord-302953-gr2kk9w4 362 16 T T NNP cord-302953-gr2kk9w4 362 17 RM rm NN cord-302953-gr2kk9w4 362 18 cells cell NNS cord-302953-gr2kk9w4 362 19 in in IN cord-302953-gr2kk9w4 362 20 the the DT cord-302953-gr2kk9w4 362 21 lung lung NN cord-302953-gr2kk9w4 362 22 after after IN cord-302953-gr2kk9w4 362 23 influenza influenza NN cord-302953-gr2kk9w4 362 24 virus virus NN cord-302953-gr2kk9w4 362 25 infection infection NN cord-302953-gr2kk9w4 362 26 [ [ -LRB- cord-302953-gr2kk9w4 362 27 108 108 CD cord-302953-gr2kk9w4 362 28 ] ] -RRB- cord-302953-gr2kk9w4 362 29 , , , cord-302953-gr2kk9w4 362 30 and and CC cord-302953-gr2kk9w4 362 31 rapid rapid JJ cord-302953-gr2kk9w4 362 32 clearance clearance NN cord-302953-gr2kk9w4 362 33 of of IN cord-302953-gr2kk9w4 362 34 LCMV LCMV NNP cord-302953-gr2kk9w4 362 35 by by IN cord-302953-gr2kk9w4 362 36 brain brain NN cord-302953-gr2kk9w4 362 37 T T NNP cord-302953-gr2kk9w4 362 38 RM rm NN cord-302953-gr2kk9w4 362 39 cells cell NNS cord-302953-gr2kk9w4 362 40 depends depend VBZ cord-302953-gr2kk9w4 362 41 on on IN cord-302953-gr2kk9w4 362 42 IFN IFN NNP cord-302953-gr2kk9w4 362 43 - - HYPH cord-302953-gr2kk9w4 362 44 γ γ NNP cord-302953-gr2kk9w4 362 45 signaling signal VBG cord-302953-gr2kk9w4 362 46 and and CC cord-302953-gr2kk9w4 362 47 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 362 48 granule granule NN cord-302953-gr2kk9w4 362 49 release release NN cord-302953-gr2kk9w4 362 50 [ [ -LRB- cord-302953-gr2kk9w4 362 51 107 107 CD cord-302953-gr2kk9w4 362 52 ] ] -RRB- cord-302953-gr2kk9w4 362 53 . . . cord-302953-gr2kk9w4 363 1 Brains brain NNS cord-302953-gr2kk9w4 363 2 of of IN cord-302953-gr2kk9w4 363 3 SINV SINV NNP cord-302953-gr2kk9w4 363 4 - - HYPH cord-302953-gr2kk9w4 363 5 infected infect VBN cord-302953-gr2kk9w4 363 6 mice mouse NNS cord-302953-gr2kk9w4 363 7 defective defective JJ cord-302953-gr2kk9w4 363 8 in in IN cord-302953-gr2kk9w4 363 9 IFN IFN NNP cord-302953-gr2kk9w4 363 10 - - HYPH cord-302953-gr2kk9w4 363 11 γ γ NNP cord-302953-gr2kk9w4 363 12 signaling signaling NN cord-302953-gr2kk9w4 363 13 had have VBD cord-302953-gr2kk9w4 363 14 both both DT cord-302953-gr2kk9w4 363 15 fewer few JJR cord-302953-gr2kk9w4 363 16 CD4 CD4 NNP cord-302953-gr2kk9w4 363 17 + + CC cord-302953-gr2kk9w4 363 18 T t NN cord-302953-gr2kk9w4 363 19 cells cell NNS cord-302953-gr2kk9w4 363 20 and and CC cord-302953-gr2kk9w4 363 21 CD8 CD8 NNP cord-302953-gr2kk9w4 363 22 + + CC cord-302953-gr2kk9w4 363 23 T T NNP cord-302953-gr2kk9w4 363 24 RM rm NN cord-302953-gr2kk9w4 363 25 cells cell NNS cord-302953-gr2kk9w4 363 26 than than IN cord-302953-gr2kk9w4 363 27 WT WT NNP cord-302953-gr2kk9w4 363 28 mice mouse NNS cord-302953-gr2kk9w4 363 29 , , , cord-302953-gr2kk9w4 363 30 indicating indicate VBG cord-302953-gr2kk9w4 363 31 a a DT cord-302953-gr2kk9w4 363 32 need need NN cord-302953-gr2kk9w4 363 33 for for IN cord-302953-gr2kk9w4 363 34 IFN IFN NNP cord-302953-gr2kk9w4 363 35 - - HYPH cord-302953-gr2kk9w4 363 36 γ γ NN cord-302953-gr2kk9w4 363 37 to to TO cord-302953-gr2kk9w4 363 38 promote promote VB cord-302953-gr2kk9w4 363 39 the the DT cord-302953-gr2kk9w4 363 40 residence residence NN cord-302953-gr2kk9w4 363 41 of of IN cord-302953-gr2kk9w4 363 42 T T NNP cord-302953-gr2kk9w4 363 43 RM RM NNP cord-302953-gr2kk9w4 363 44 cells cell NNS cord-302953-gr2kk9w4 363 45 in in IN cord-302953-gr2kk9w4 363 46 the the DT cord-302953-gr2kk9w4 363 47 brain brain NN cord-302953-gr2kk9w4 363 48 after after IN cord-302953-gr2kk9w4 363 49 infection infection NN cord-302953-gr2kk9w4 363 50 . . . cord-302953-gr2kk9w4 364 1 In in IN cord-302953-gr2kk9w4 364 2 conclusion conclusion NN cord-302953-gr2kk9w4 364 3 , , , cord-302953-gr2kk9w4 364 4 IFN IFN NNP cord-302953-gr2kk9w4 364 5 - - HYPH cord-302953-gr2kk9w4 364 6 γ γ NNP cord-302953-gr2kk9w4 364 7 signaling signaling NN cord-302953-gr2kk9w4 364 8 has have VBZ cord-302953-gr2kk9w4 364 9 both both DT cord-302953-gr2kk9w4 364 10 positive positive JJ cord-302953-gr2kk9w4 364 11 and and CC cord-302953-gr2kk9w4 364 12 negative negative JJ cord-302953-gr2kk9w4 364 13 effects effect NNS cord-302953-gr2kk9w4 364 14 on on IN cord-302953-gr2kk9w4 364 15 SINV SINV NNP cord-302953-gr2kk9w4 364 16 clearance clearance NN cord-302953-gr2kk9w4 364 17 and and CC cord-302953-gr2kk9w4 364 18 control control NN cord-302953-gr2kk9w4 364 19 . . . cord-302953-gr2kk9w4 365 1 IFN IFN NNP cord-302953-gr2kk9w4 365 2 - - HYPH cord-302953-gr2kk9w4 365 3 γ γ NNP cord-302953-gr2kk9w4 365 4 facilitates facilitate VBZ cord-302953-gr2kk9w4 365 5 infectious infectious JJ cord-302953-gr2kk9w4 365 6 virus virus NN cord-302953-gr2kk9w4 365 7 clearance clearance NN cord-302953-gr2kk9w4 365 8 through through IN cord-302953-gr2kk9w4 365 9 direct direct JJ cord-302953-gr2kk9w4 365 10 antiviral antiviral JJ cord-302953-gr2kk9w4 365 11 effects effect NNS cord-302953-gr2kk9w4 365 12 on on IN cord-302953-gr2kk9w4 365 13 infected infected JJ cord-302953-gr2kk9w4 365 14 neurons neuron NNS cord-302953-gr2kk9w4 365 15 and and CC cord-302953-gr2kk9w4 365 16 inducing induce VBG cord-302953-gr2kk9w4 365 17 production production NN cord-302953-gr2kk9w4 365 18 of of IN cord-302953-gr2kk9w4 365 19 B b NN cord-302953-gr2kk9w4 365 20 cell cell NN cord-302953-gr2kk9w4 365 21 - - HYPH cord-302953-gr2kk9w4 365 22 attracting attract VBG cord-302953-gr2kk9w4 365 23 chemokines chemokine NNS cord-302953-gr2kk9w4 365 24 that that WDT cord-302953-gr2kk9w4 365 25 fosters foster VBZ cord-302953-gr2kk9w4 365 26 local local JJ cord-302953-gr2kk9w4 365 27 production production NN cord-302953-gr2kk9w4 365 28 of of IN cord-302953-gr2kk9w4 365 29 anti anti JJ cord-302953-gr2kk9w4 365 30 - - JJ cord-302953-gr2kk9w4 365 31 SINV sinv JJ cord-302953-gr2kk9w4 365 32 antibody antibody NN cord-302953-gr2kk9w4 365 33 [ [ -LRB- cord-302953-gr2kk9w4 365 34 9 9 CD cord-302953-gr2kk9w4 365 35 ] ] -RRB- cord-302953-gr2kk9w4 365 36 . . . cord-302953-gr2kk9w4 366 1 However however RB cord-302953-gr2kk9w4 366 2 , , , cord-302953-gr2kk9w4 366 3 IFN IFN NNP cord-302953-gr2kk9w4 366 4 - - HYPH cord-302953-gr2kk9w4 366 5 γ γ NNP cord-302953-gr2kk9w4 366 6 impairs impair VBZ cord-302953-gr2kk9w4 366 7 viral viral JJ cord-302953-gr2kk9w4 366 8 RNA RNA NNP cord-302953-gr2kk9w4 366 9 clearance clearance NN cord-302953-gr2kk9w4 366 10 , , , cord-302953-gr2kk9w4 366 11 possibly possibly RB cord-302953-gr2kk9w4 366 12 by by IN cord-302953-gr2kk9w4 366 13 suppressing suppress VBG cord-302953-gr2kk9w4 366 14 the the DT cord-302953-gr2kk9w4 366 15 CD8 CD8 NNP cord-302953-gr2kk9w4 366 16 + + CC cord-302953-gr2kk9w4 366 17 T T NNP cord-302953-gr2kk9w4 366 18 cell cell NN cord-302953-gr2kk9w4 366 19 response response NN cord-302953-gr2kk9w4 366 20 in in IN cord-302953-gr2kk9w4 366 21 the the DT cord-302953-gr2kk9w4 366 22 CNS CNS NNP cord-302953-gr2kk9w4 366 23 and and CC cord-302953-gr2kk9w4 366 24 granzyme granzyme NNS cord-302953-gr2kk9w4 366 25 B B NNP cord-302953-gr2kk9w4 366 26 production production NN cord-302953-gr2kk9w4 366 27 . . . cord-302953-gr2kk9w4 367 1 Finally finally RB cord-302953-gr2kk9w4 367 2 , , , cord-302953-gr2kk9w4 367 3 IFN IFN NNP cord-302953-gr2kk9w4 367 4 - - HYPH cord-302953-gr2kk9w4 367 5 γ γ NNP cord-302953-gr2kk9w4 367 6 promotes promote VBZ cord-302953-gr2kk9w4 367 7 the the DT cord-302953-gr2kk9w4 367 8 development development NN cord-302953-gr2kk9w4 367 9 of of IN cord-302953-gr2kk9w4 367 10 CD8 CD8 NNP cord-302953-gr2kk9w4 367 11 + + CC cord-302953-gr2kk9w4 367 12 T T NNP cord-302953-gr2kk9w4 367 13 RM rm NN cord-302953-gr2kk9w4 367 14 cells cell NNS cord-302953-gr2kk9w4 367 15 in in IN cord-302953-gr2kk9w4 367 16 the the DT cord-302953-gr2kk9w4 367 17 brain brain NN cord-302953-gr2kk9w4 367 18 , , , cord-302953-gr2kk9w4 367 19 likely likely RB cord-302953-gr2kk9w4 367 20 helping help VBG cord-302953-gr2kk9w4 367 21 prevent prevent VB cord-302953-gr2kk9w4 367 22 reactivation reactivation NN cord-302953-gr2kk9w4 367 23 of of IN cord-302953-gr2kk9w4 367 24 persistent persistent JJ cord-302953-gr2kk9w4 367 25 virus virus NN cord-302953-gr2kk9w4 367 26 . . . cord-302953-gr2kk9w4 368 1 Better well JJR cord-302953-gr2kk9w4 368 2 understanding understanding NN cord-302953-gr2kk9w4 368 3 of of IN cord-302953-gr2kk9w4 368 4 the the DT cord-302953-gr2kk9w4 368 5 complicated complicated JJ cord-302953-gr2kk9w4 368 6 interplay interplay NN cord-302953-gr2kk9w4 368 7 between between IN cord-302953-gr2kk9w4 368 8 the the DT cord-302953-gr2kk9w4 368 9 virus virus NN cord-302953-gr2kk9w4 368 10 and and CC cord-302953-gr2kk9w4 368 11 host host NN cord-302953-gr2kk9w4 368 12 immune immune JJ cord-302953-gr2kk9w4 368 13 system system NN cord-302953-gr2kk9w4 368 14 in in IN cord-302953-gr2kk9w4 368 15 inducing induce VBG cord-302953-gr2kk9w4 368 16 pathology pathology NN cord-302953-gr2kk9w4 368 17 and and CC cord-302953-gr2kk9w4 368 18 promoting promote VBG cord-302953-gr2kk9w4 368 19 virus virus NN cord-302953-gr2kk9w4 368 20 clearance clearance NN cord-302953-gr2kk9w4 368 21 is be VBZ cord-302953-gr2kk9w4 368 22 critical critical JJ cord-302953-gr2kk9w4 368 23 to to IN cord-302953-gr2kk9w4 368 24 developing develop VBG cord-302953-gr2kk9w4 368 25 effective effective JJ cord-302953-gr2kk9w4 368 26 therapies therapy NNS cord-302953-gr2kk9w4 368 27 . . . cord-302953-gr2kk9w4 369 1 The the DT cord-302953-gr2kk9w4 369 2 immune immune JJ cord-302953-gr2kk9w4 369 3 response response NN cord-302953-gr2kk9w4 369 4 in in IN cord-302953-gr2kk9w4 369 5 viral viral JJ cord-302953-gr2kk9w4 369 6 encephalitis encephalitis NN cord-302953-gr2kk9w4 369 7 Induction Induction NNP cord-302953-gr2kk9w4 369 8 of of IN cord-302953-gr2kk9w4 369 9 MHC MHC NNP cord-302953-gr2kk9w4 369 10 class class NN cord-302953-gr2kk9w4 369 11 I -PRON- PRP cord-302953-gr2kk9w4 369 12 genes gene NNS cord-302953-gr2kk9w4 369 13 in in IN cord-302953-gr2kk9w4 369 14 neurons neuron NNS cord-302953-gr2kk9w4 370 1 The the DT cord-302953-gr2kk9w4 370 2 role role NN cord-302953-gr2kk9w4 370 3 of of IN cord-302953-gr2kk9w4 370 4 CD8(+ CD8(+ NNP cord-302953-gr2kk9w4 370 5 ) ) -RRB- cord-302953-gr2kk9w4 370 6 T t NN cord-302953-gr2kk9w4 370 7 cells cell NNS cord-302953-gr2kk9w4 370 8 and and CC cord-302953-gr2kk9w4 370 9 major major JJ cord-302953-gr2kk9w4 370 10 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 370 11 complex complex NN cord-302953-gr2kk9w4 370 12 class class NN cord-302953-gr2kk9w4 371 1 I -PRON- PRP cord-302953-gr2kk9w4 371 2 expression expression VBP cord-302953-gr2kk9w4 371 3 in in IN cord-302953-gr2kk9w4 371 4 the the DT cord-302953-gr2kk9w4 371 5 central central JJ cord-302953-gr2kk9w4 371 6 nervous nervous JJ cord-302953-gr2kk9w4 371 7 system system NN cord-302953-gr2kk9w4 371 8 of of IN cord-302953-gr2kk9w4 371 9 mice mouse NNS cord-302953-gr2kk9w4 371 10 infected infect VBN cord-302953-gr2kk9w4 371 11 with with IN cord-302953-gr2kk9w4 371 12 neurovirulent neurovirulent NN cord-302953-gr2kk9w4 371 13 Sindbis Sindbis NNP cord-302953-gr2kk9w4 371 14 virus virus NN cord-302953-gr2kk9w4 371 15 Fields Fields NNP cord-302953-gr2kk9w4 371 16 Virology Virology NNP cord-302953-gr2kk9w4 372 1 Alphavirus Alphavirus NNP cord-302953-gr2kk9w4 372 2 - - HYPH cord-302953-gr2kk9w4 372 3 Induced induce VBN cord-302953-gr2kk9w4 372 4 Encephalomyelitis Encephalomyelitis NNP cord-302953-gr2kk9w4 372 5 : : : cord-302953-gr2kk9w4 372 6 Antibody antibody NN cord-302953-gr2kk9w4 372 7 - - HYPH cord-302953-gr2kk9w4 372 8 Secreting secrete VBG cord-302953-gr2kk9w4 372 9 Cells cell NNS cord-302953-gr2kk9w4 372 10 and and CC cord-302953-gr2kk9w4 372 11 Viral Viral NNP cord-302953-gr2kk9w4 372 12 Clearance Clearance NNP cord-302953-gr2kk9w4 372 13 from from IN cord-302953-gr2kk9w4 372 14 the the DT cord-302953-gr2kk9w4 372 15 Nervous Nervous NNP cord-302953-gr2kk9w4 372 16 System System NNP cord-302953-gr2kk9w4 372 17 Antibody Antibody NNP cord-302953-gr2kk9w4 372 18 - - HYPH cord-302953-gr2kk9w4 372 19 mediated mediate VBN cord-302953-gr2kk9w4 372 20 clearance clearance NN cord-302953-gr2kk9w4 372 21 of of IN cord-302953-gr2kk9w4 372 22 alphavirus alphavirus NNP cord-302953-gr2kk9w4 372 23 infection infection NN cord-302953-gr2kk9w4 372 24 from from IN cord-302953-gr2kk9w4 372 25 neurons neuron NNS cord-302953-gr2kk9w4 373 1 Interferon interferon NN cord-302953-gr2kk9w4 373 2 - - HYPH cord-302953-gr2kk9w4 373 3 gamma gamma NN cord-302953-gr2kk9w4 373 4 - - HYPH cord-302953-gr2kk9w4 373 5 mediated mediate VBN cord-302953-gr2kk9w4 373 6 site site NN cord-302953-gr2kk9w4 373 7 - - HYPH cord-302953-gr2kk9w4 373 8 specific specific JJ cord-302953-gr2kk9w4 373 9 clearance clearance NN cord-302953-gr2kk9w4 373 10 of of IN cord-302953-gr2kk9w4 373 11 alphavirus alphavirus NN cord-302953-gr2kk9w4 373 12 from from IN cord-302953-gr2kk9w4 373 13 CNS CNS NNP cord-302953-gr2kk9w4 373 14 neurons neuron NNS cord-302953-gr2kk9w4 373 15 Synergistic synergistic JJ cord-302953-gr2kk9w4 373 16 Roles Roles NNPS cord-302953-gr2kk9w4 373 17 of of IN cord-302953-gr2kk9w4 373 18 Antibody Antibody NNP cord-302953-gr2kk9w4 373 19 and and CC cord-302953-gr2kk9w4 373 20 Interferon Interferon NNP cord-302953-gr2kk9w4 373 21 in in IN cord-302953-gr2kk9w4 373 22 Noncytolytic Noncytolytic NNP cord-302953-gr2kk9w4 373 23 Clearance Clearance NNP cord-302953-gr2kk9w4 373 24 of of IN cord-302953-gr2kk9w4 373 25 Sindbis Sindbis NNP cord-302953-gr2kk9w4 373 26 Virus Virus NNP cord-302953-gr2kk9w4 373 27 from from IN cord-302953-gr2kk9w4 373 28 Different different JJ cord-302953-gr2kk9w4 373 29 Regions region NNS cord-302953-gr2kk9w4 373 30 of of IN cord-302953-gr2kk9w4 373 31 the the DT cord-302953-gr2kk9w4 373 32 Central Central NNP cord-302953-gr2kk9w4 373 33 Nervous Nervous NNP cord-302953-gr2kk9w4 373 34 System System NNP cord-302953-gr2kk9w4 374 1 Interferon interferon NN cord-302953-gr2kk9w4 374 2 gamma gamma NN cord-302953-gr2kk9w4 374 3 modulation modulation NN cord-302953-gr2kk9w4 374 4 of of IN cord-302953-gr2kk9w4 374 5 disease disease NN cord-302953-gr2kk9w4 374 6 manifestation manifestation NN cord-302953-gr2kk9w4 374 7 and and CC cord-302953-gr2kk9w4 374 8 the the DT cord-302953-gr2kk9w4 374 9 local local JJ cord-302953-gr2kk9w4 374 10 antibody antibody NN cord-302953-gr2kk9w4 374 11 response response NN cord-302953-gr2kk9w4 374 12 to to IN cord-302953-gr2kk9w4 374 13 alphavirus alphavirus NNP cord-302953-gr2kk9w4 374 14 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 374 15 Persistence persistence NN cord-302953-gr2kk9w4 374 16 of of IN cord-302953-gr2kk9w4 374 17 viral viral JJ cord-302953-gr2kk9w4 374 18 RNA RNA NNP cord-302953-gr2kk9w4 374 19 in in IN cord-302953-gr2kk9w4 374 20 mouse mouse NN cord-302953-gr2kk9w4 374 21 brains brain NNS cord-302953-gr2kk9w4 374 22 after after IN cord-302953-gr2kk9w4 374 23 recovery recovery NN cord-302953-gr2kk9w4 374 24 from from IN cord-302953-gr2kk9w4 374 25 acute acute JJ cord-302953-gr2kk9w4 374 26 alphavirus alphavirus NNP cord-302953-gr2kk9w4 374 27 encephalitis encephalitis RB cord-302953-gr2kk9w4 374 28 Virus virus NN cord-302953-gr2kk9w4 374 29 specificity specificity NN cord-302953-gr2kk9w4 374 30 and and CC cord-302953-gr2kk9w4 374 31 isotype isotype JJ cord-302953-gr2kk9w4 374 32 expression expression NN cord-302953-gr2kk9w4 374 33 of of IN cord-302953-gr2kk9w4 374 34 intraparenchymal intraparenchymal JJ cord-302953-gr2kk9w4 374 35 antibody antibody NN cord-302953-gr2kk9w4 374 36 - - HYPH cord-302953-gr2kk9w4 374 37 secreting secrete VBG cord-302953-gr2kk9w4 374 38 cells cell NNS cord-302953-gr2kk9w4 374 39 during during IN cord-302953-gr2kk9w4 374 40 Sindbis Sindbis NNP cord-302953-gr2kk9w4 374 41 virus virus NN cord-302953-gr2kk9w4 374 42 encephalitis encephalitis RB cord-302953-gr2kk9w4 374 43 in in IN cord-302953-gr2kk9w4 374 44 mice mouse NNS cord-302953-gr2kk9w4 375 1 Interleukin interleukin NN cord-302953-gr2kk9w4 375 2 10 10 CD cord-302953-gr2kk9w4 375 3 modulation modulation NN cord-302953-gr2kk9w4 375 4 of of IN cord-302953-gr2kk9w4 375 5 pathogenic pathogenic JJ cord-302953-gr2kk9w4 375 6 Th17 Th17 NNP cord-302953-gr2kk9w4 375 7 cells cell NNS cord-302953-gr2kk9w4 375 8 during during IN cord-302953-gr2kk9w4 375 9 fatal fatal JJ cord-302953-gr2kk9w4 375 10 alphavirus alphavirus NNP cord-302953-gr2kk9w4 375 11 encephalomyelitis encephalomyelitis NNP cord-302953-gr2kk9w4 375 12 Contribution Contribution NNP cord-302953-gr2kk9w4 375 13 of of IN cord-302953-gr2kk9w4 375 14 T T NNP cord-302953-gr2kk9w4 375 15 cells cell NNS cord-302953-gr2kk9w4 375 16 to to IN cord-302953-gr2kk9w4 375 17 mortality mortality NN cord-302953-gr2kk9w4 375 18 in in IN cord-302953-gr2kk9w4 375 19 neurovirulent neurovirulent NN cord-302953-gr2kk9w4 375 20 Sindbis Sindbis NNP cord-302953-gr2kk9w4 375 21 virus virus NN cord-302953-gr2kk9w4 375 22 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 375 23 Interleukin-10 interleukin-10 NN cord-302953-gr2kk9w4 375 24 modulation modulation NN cord-302953-gr2kk9w4 375 25 of of IN cord-302953-gr2kk9w4 375 26 virus virus NN cord-302953-gr2kk9w4 375 27 clearance clearance NN cord-302953-gr2kk9w4 375 28 and and CC cord-302953-gr2kk9w4 375 29 disease disease NN cord-302953-gr2kk9w4 375 30 in in IN cord-302953-gr2kk9w4 375 31 mice mouse NNS cord-302953-gr2kk9w4 375 32 with with IN cord-302953-gr2kk9w4 375 33 alphaviral alphaviral NNP cord-302953-gr2kk9w4 375 34 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 375 35 Biologic Biologic NNP cord-302953-gr2kk9w4 375 36 functions function NNS cord-302953-gr2kk9w4 375 37 of of IN cord-302953-gr2kk9w4 375 38 the the DT cord-302953-gr2kk9w4 375 39 IFN IFN NNP cord-302953-gr2kk9w4 375 40 - - HYPH cord-302953-gr2kk9w4 375 41 gamma gamma NN cord-302953-gr2kk9w4 375 42 receptors receptor NNS cord-302953-gr2kk9w4 375 43 Noncytolytic noncytolytic JJ cord-302953-gr2kk9w4 375 44 clearance clearance NN cord-302953-gr2kk9w4 375 45 of of IN cord-302953-gr2kk9w4 375 46 Sindbis Sindbis NNP cord-302953-gr2kk9w4 375 47 virus virus NN cord-302953-gr2kk9w4 375 48 infection infection NN cord-302953-gr2kk9w4 375 49 from from IN cord-302953-gr2kk9w4 375 50 neurons neuron NNS cord-302953-gr2kk9w4 375 51 by by IN cord-302953-gr2kk9w4 375 52 gamma gamma NN cord-302953-gr2kk9w4 375 53 interferon interferon NN cord-302953-gr2kk9w4 375 54 is be VBZ cord-302953-gr2kk9w4 375 55 dependent dependent JJ cord-302953-gr2kk9w4 375 56 on on IN cord-302953-gr2kk9w4 375 57 Jak Jak NNP cord-302953-gr2kk9w4 375 58 / / SYM cord-302953-gr2kk9w4 375 59 Stat Stat NNP cord-302953-gr2kk9w4 375 60 signaling signal VBG cord-302953-gr2kk9w4 375 61 The the DT cord-302953-gr2kk9w4 375 62 molecular molecular JJ cord-302953-gr2kk9w4 375 63 cell cell NN cord-302953-gr2kk9w4 375 64 biology biology NN cord-302953-gr2kk9w4 375 65 of of IN cord-302953-gr2kk9w4 375 66 interferon interferon NN cord-302953-gr2kk9w4 375 67 - - HYPH cord-302953-gr2kk9w4 375 68 gamma gamma NN cord-302953-gr2kk9w4 375 69 and and CC cord-302953-gr2kk9w4 375 70 its -PRON- PRP$ cord-302953-gr2kk9w4 375 71 receptor receptor NN cord-302953-gr2kk9w4 375 72 Antiviral antiviral JJ cord-302953-gr2kk9w4 375 73 actions action NNS cord-302953-gr2kk9w4 375 74 of of IN cord-302953-gr2kk9w4 375 75 interferons interferon NNS cord-302953-gr2kk9w4 376 1 An an DT cord-302953-gr2kk9w4 376 2 olfactory olfactory JJ cord-302953-gr2kk9w4 376 3 sensory sensory JJ cord-302953-gr2kk9w4 376 4 neuron neuron NN cord-302953-gr2kk9w4 376 5 line line NN cord-302953-gr2kk9w4 376 6 , , , cord-302953-gr2kk9w4 376 7 odora odora NNP cord-302953-gr2kk9w4 376 8 , , , cord-302953-gr2kk9w4 376 9 properly properly RB cord-302953-gr2kk9w4 376 10 targets target VBZ cord-302953-gr2kk9w4 376 11 olfactory olfactory JJ cord-302953-gr2kk9w4 376 12 proteins protein NNS cord-302953-gr2kk9w4 376 13 and and CC cord-302953-gr2kk9w4 376 14 responds respond VBZ cord-302953-gr2kk9w4 376 15 to to IN cord-302953-gr2kk9w4 376 16 odorants odorant NNS cord-302953-gr2kk9w4 376 17 Molecular molecular JJ cord-302953-gr2kk9w4 376 18 basis basis NN cord-302953-gr2kk9w4 376 19 of of IN cord-302953-gr2kk9w4 376 20 Sindbis Sindbis NNP cord-302953-gr2kk9w4 376 21 virus virus NN cord-302953-gr2kk9w4 376 22 neurovirulence neurovirulence NN cord-302953-gr2kk9w4 376 23 in in IN cord-302953-gr2kk9w4 376 24 mice mouse NNS cord-302953-gr2kk9w4 377 1 The the DT cord-302953-gr2kk9w4 377 2 nsP3 nsP3 NNS cord-302953-gr2kk9w4 377 3 macrodomain macrodomain NNP cord-302953-gr2kk9w4 377 4 is be VBZ cord-302953-gr2kk9w4 377 5 important important JJ cord-302953-gr2kk9w4 377 6 for for IN cord-302953-gr2kk9w4 377 7 Sindbis Sindbis NNP cord-302953-gr2kk9w4 377 8 virus virus NN cord-302953-gr2kk9w4 377 9 replication replication NN cord-302953-gr2kk9w4 377 10 in in IN cord-302953-gr2kk9w4 377 11 neurons neuron NNS cord-302953-gr2kk9w4 377 12 and and CC cord-302953-gr2kk9w4 377 13 neurovirulence neurovirulence NN cord-302953-gr2kk9w4 377 14 in in IN cord-302953-gr2kk9w4 377 15 mice mice NNP cord-302953-gr2kk9w4 377 16 Basis Basis NNP cord-302953-gr2kk9w4 377 17 of of IN cord-302953-gr2kk9w4 377 18 neurovirulence neurovirulence NN cord-302953-gr2kk9w4 377 19 in in IN cord-302953-gr2kk9w4 377 20 Sindbis Sindbis NNP cord-302953-gr2kk9w4 377 21 virus virus NN cord-302953-gr2kk9w4 377 22 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 377 23 of of IN cord-302953-gr2kk9w4 377 24 mice mouse NNS cord-302953-gr2kk9w4 378 1 The the DT cord-302953-gr2kk9w4 378 2 inflammatory inflammatory JJ cord-302953-gr2kk9w4 378 3 response response NN cord-302953-gr2kk9w4 378 4 to to IN cord-302953-gr2kk9w4 378 5 nonfatal nonfatal JJ cord-302953-gr2kk9w4 378 6 Sindbis Sindbis NNP cord-302953-gr2kk9w4 378 7 virus virus NN cord-302953-gr2kk9w4 378 8 infection infection NN cord-302953-gr2kk9w4 378 9 of of IN cord-302953-gr2kk9w4 378 10 the the DT cord-302953-gr2kk9w4 378 11 nervous nervous JJ cord-302953-gr2kk9w4 378 12 system system NN cord-302953-gr2kk9w4 378 13 is be VBZ cord-302953-gr2kk9w4 378 14 more more RBR cord-302953-gr2kk9w4 378 15 severe severe JJ cord-302953-gr2kk9w4 378 16 in in IN cord-302953-gr2kk9w4 378 17 SJL SJL NNP cord-302953-gr2kk9w4 378 18 than than IN cord-302953-gr2kk9w4 378 19 in in IN cord-302953-gr2kk9w4 378 20 BALB BALB NNP cord-302953-gr2kk9w4 378 21 / / SYM cord-302953-gr2kk9w4 378 22 c c NN cord-302953-gr2kk9w4 378 23 mice mouse NNS cord-302953-gr2kk9w4 378 24 and and CC cord-302953-gr2kk9w4 378 25 is be VBZ cord-302953-gr2kk9w4 378 26 associated associate VBN cord-302953-gr2kk9w4 378 27 with with IN cord-302953-gr2kk9w4 378 28 low low JJ cord-302953-gr2kk9w4 378 29 levels level NNS cord-302953-gr2kk9w4 378 30 of of IN cord-302953-gr2kk9w4 378 31 IL-4 IL-4 NNP cord-302953-gr2kk9w4 378 32 mRNA mRNA NNP cord-302953-gr2kk9w4 378 33 and and CC cord-302953-gr2kk9w4 378 34 high high JJ cord-302953-gr2kk9w4 378 35 levels level NNS cord-302953-gr2kk9w4 378 36 of of IN cord-302953-gr2kk9w4 378 37 IL-10-producing IL-10-producing NNP cord-302953-gr2kk9w4 378 38 CD4 CD4 NNP cord-302953-gr2kk9w4 378 39 + + CC cord-302953-gr2kk9w4 378 40 T t NN cord-302953-gr2kk9w4 378 41 cells cell NNS cord-302953-gr2kk9w4 378 42 Glutamine glutamine NN cord-302953-gr2kk9w4 378 43 antagonist antagonist NN cord-302953-gr2kk9w4 378 44 - - HYPH cord-302953-gr2kk9w4 378 45 mediated mediate VBN cord-302953-gr2kk9w4 378 46 immune immune JJ cord-302953-gr2kk9w4 378 47 suppression suppression NN cord-302953-gr2kk9w4 378 48 decreases decrease VBZ cord-302953-gr2kk9w4 378 49 pathology pathology NN cord-302953-gr2kk9w4 378 50 but but CC cord-302953-gr2kk9w4 378 51 delays delay VBZ cord-302953-gr2kk9w4 378 52 virus virus NN cord-302953-gr2kk9w4 378 53 clearance clearance NN cord-302953-gr2kk9w4 378 54 in in IN cord-302953-gr2kk9w4 378 55 mice mouse NNS cord-302953-gr2kk9w4 378 56 during during IN cord-302953-gr2kk9w4 378 57 nonfatal nonfatal JJ cord-302953-gr2kk9w4 378 58 alphavirus alphavirus NN cord-302953-gr2kk9w4 378 59 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 378 60 Immunity immunity NN cord-302953-gr2kk9w4 378 61 - - HYPH cord-302953-gr2kk9w4 378 62 related relate VBN cord-302953-gr2kk9w4 378 63 GTPase GTPase NNP cord-302953-gr2kk9w4 378 64 M M NNP cord-302953-gr2kk9w4 378 65 ( ( -LRB- cord-302953-gr2kk9w4 378 66 IRGM IRGM NNP cord-302953-gr2kk9w4 378 67 ) ) -RRB- cord-302953-gr2kk9w4 378 68 proteins protein NNS cord-302953-gr2kk9w4 378 69 influence influence VBP cord-302953-gr2kk9w4 378 70 the the DT cord-302953-gr2kk9w4 378 71 localization localization NN cord-302953-gr2kk9w4 378 72 of of IN cord-302953-gr2kk9w4 378 73 guanylate guanylate NN cord-302953-gr2kk9w4 378 74 - - HYPH cord-302953-gr2kk9w4 378 75 binding bind VBG cord-302953-gr2kk9w4 378 76 protein protein NN cord-302953-gr2kk9w4 378 77 2 2 CD cord-302953-gr2kk9w4 378 78 ( ( -LRB- cord-302953-gr2kk9w4 378 79 GBP2 GBP2 NNP cord-302953-gr2kk9w4 378 80 ) ) -RRB- cord-302953-gr2kk9w4 378 81 by by IN cord-302953-gr2kk9w4 378 82 modulating modulate VBG cord-302953-gr2kk9w4 378 83 macroautophagy macroautophagy NNS cord-302953-gr2kk9w4 378 84 Characterization characterization NN cord-302953-gr2kk9w4 378 85 of of IN cord-302953-gr2kk9w4 378 86 the the DT cord-302953-gr2kk9w4 378 87 2"-5-"oligoadenylate 2"-5-"oligoadenylate JJ cord-302953-gr2kk9w4 378 88 synthetase synthetase NNP cord-302953-gr2kk9w4 378 89 ubiquitin ubiquitin NN cord-302953-gr2kk9w4 378 90 - - HYPH cord-302953-gr2kk9w4 378 91 like like JJ cord-302953-gr2kk9w4 378 92 family family NN cord-302953-gr2kk9w4 378 93 the the DT cord-302953-gr2kk9w4 378 94 antiviral antiviral JJ cord-302953-gr2kk9w4 378 95 response response NN cord-302953-gr2kk9w4 378 96 . . . cord-302953-gr2kk9w4 379 1 Microbes microbe NNS cord-302953-gr2kk9w4 379 2 Infect infect VBP cord-302953-gr2kk9w4 379 3 Multiple multiple JJ cord-302953-gr2kk9w4 379 4 interferon interferon NN cord-302953-gr2kk9w4 379 5 stimulated stimulate VBD cord-302953-gr2kk9w4 379 6 genes gene NNS cord-302953-gr2kk9w4 379 7 synergize synergize VBP cord-302953-gr2kk9w4 379 8 with with IN cord-302953-gr2kk9w4 379 9 the the DT cord-302953-gr2kk9w4 379 10 zinc zinc NN cord-302953-gr2kk9w4 379 11 finger finger NN cord-302953-gr2kk9w4 379 12 antiviral antiviral JJ cord-302953-gr2kk9w4 379 13 protein protein NN cord-302953-gr2kk9w4 379 14 to to TO cord-302953-gr2kk9w4 379 15 mediate mediate VB cord-302953-gr2kk9w4 379 16 anti anti JJ cord-302953-gr2kk9w4 379 17 - - JJ cord-302953-gr2kk9w4 379 18 alphavirus alphavirus JJ cord-302953-gr2kk9w4 379 19 activity activity NN cord-302953-gr2kk9w4 379 20 Inhibition inhibition NN cord-302953-gr2kk9w4 379 21 of of IN cord-302953-gr2kk9w4 379 22 Japanese japanese JJ cord-302953-gr2kk9w4 379 23 encephalitis encephalitis RB cord-302953-gr2kk9w4 379 24 virus virus NN cord-302953-gr2kk9w4 379 25 infection infection NN cord-302953-gr2kk9w4 379 26 by by IN cord-302953-gr2kk9w4 379 27 the the DT cord-302953-gr2kk9w4 379 28 host host NN cord-302953-gr2kk9w4 379 29 zinc zinc NN cord-302953-gr2kk9w4 379 30 - - HYPH cord-302953-gr2kk9w4 379 31 finger finger NN cord-302953-gr2kk9w4 379 32 antiviral antiviral JJ cord-302953-gr2kk9w4 379 33 protein protein NN cord-302953-gr2kk9w4 379 34 Mice mouse NNS cord-302953-gr2kk9w4 379 35 deficient deficient JJ cord-302953-gr2kk9w4 379 36 in in IN cord-302953-gr2kk9w4 379 37 interferon interferon NN cord-302953-gr2kk9w4 379 38 - - HYPH cord-302953-gr2kk9w4 379 39 gamma gamma NN cord-302953-gr2kk9w4 379 40 or or CC cord-302953-gr2kk9w4 379 41 interferon interferon NN cord-302953-gr2kk9w4 379 42 - - HYPH cord-302953-gr2kk9w4 379 43 gamma gamma NN cord-302953-gr2kk9w4 379 44 receptor receptor NN cord-302953-gr2kk9w4 379 45 1 1 CD cord-302953-gr2kk9w4 379 46 have have VBP cord-302953-gr2kk9w4 379 47 distinct distinct JJ cord-302953-gr2kk9w4 379 48 inflammatory inflammatory JJ cord-302953-gr2kk9w4 379 49 responses response NNS cord-302953-gr2kk9w4 379 50 to to IN cord-302953-gr2kk9w4 379 51 acute acute JJ cord-302953-gr2kk9w4 379 52 viral viral JJ cord-302953-gr2kk9w4 379 53 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 379 54 Distinct distinct JJ cord-302953-gr2kk9w4 379 55 immune immune JJ cord-302953-gr2kk9w4 379 56 responses response NNS cord-302953-gr2kk9w4 379 57 in in IN cord-302953-gr2kk9w4 379 58 resistant resistant JJ cord-302953-gr2kk9w4 379 59 and and CC cord-302953-gr2kk9w4 379 60 susceptible susceptible JJ cord-302953-gr2kk9w4 379 61 strains strain NNS cord-302953-gr2kk9w4 379 62 of of IN cord-302953-gr2kk9w4 379 63 mice mouse NNS cord-302953-gr2kk9w4 379 64 during during IN cord-302953-gr2kk9w4 379 65 neurovirulent neurovirulent NNP cord-302953-gr2kk9w4 379 66 alphavirus alphavirus NNP cord-302953-gr2kk9w4 379 67 encephalomyelitis encephalomyelitis NNP cord-302953-gr2kk9w4 379 68 Immunopathogenesis Immunopathogenesis NNP cord-302953-gr2kk9w4 379 69 and and CC cord-302953-gr2kk9w4 379 70 immune immune JJ cord-302953-gr2kk9w4 379 71 modulation modulation NN cord-302953-gr2kk9w4 379 72 of of IN cord-302953-gr2kk9w4 379 73 Venezuelan venezuelan JJ cord-302953-gr2kk9w4 379 74 equine equine NN cord-302953-gr2kk9w4 379 75 encephalitis encephalitis NN cord-302953-gr2kk9w4 379 76 virus virus NN cord-302953-gr2kk9w4 379 77 - - HYPH cord-302953-gr2kk9w4 379 78 induced induce VBN cord-302953-gr2kk9w4 379 79 disease disease NN cord-302953-gr2kk9w4 379 80 in in IN cord-302953-gr2kk9w4 379 81 the the DT cord-302953-gr2kk9w4 379 82 mouse mouse NN cord-302953-gr2kk9w4 379 83 Protective protective JJ cord-302953-gr2kk9w4 379 84 effects effect NNS cord-302953-gr2kk9w4 379 85 of of IN cord-302953-gr2kk9w4 379 86 glutamine glutamine NN cord-302953-gr2kk9w4 379 87 antagonist antagonist NN cord-302953-gr2kk9w4 379 88 6-diazo-5-oxo 6-diazo-5-oxo NNP cord-302953-gr2kk9w4 379 89 - - HYPH cord-302953-gr2kk9w4 379 90 l l NN cord-302953-gr2kk9w4 379 91 - - HYPH cord-302953-gr2kk9w4 379 92 norleucine norleucine NN cord-302953-gr2kk9w4 379 93 in in IN cord-302953-gr2kk9w4 379 94 mice mouse NNS cord-302953-gr2kk9w4 379 95 with with IN cord-302953-gr2kk9w4 379 96 alphavirus alphavirus NNP cord-302953-gr2kk9w4 379 97 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 379 98 Cytotoxic Cytotoxic NNP cord-302953-gr2kk9w4 379 99 and and CC cord-302953-gr2kk9w4 379 100 non non JJ cord-302953-gr2kk9w4 379 101 - - JJ cord-302953-gr2kk9w4 379 102 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 379 103 roles role NNS cord-302953-gr2kk9w4 379 104 of of IN cord-302953-gr2kk9w4 379 105 the the DT cord-302953-gr2kk9w4 379 106 CTL CTL NNP cord-302953-gr2kk9w4 379 107 / / SYM cord-302953-gr2kk9w4 379 108 NK NK NNP cord-302953-gr2kk9w4 379 109 protease protease NN cord-302953-gr2kk9w4 379 110 granzyme granzyme NNS cord-302953-gr2kk9w4 379 111 B B NNP cord-302953-gr2kk9w4 379 112 Sensitive sensitive JJ cord-302953-gr2kk9w4 379 113 and and CC cord-302953-gr2kk9w4 379 114 viable viable JJ cord-302953-gr2kk9w4 379 115 identification identification NN cord-302953-gr2kk9w4 379 116 of of IN cord-302953-gr2kk9w4 379 117 antigen antigen NN cord-302953-gr2kk9w4 379 118 - - HYPH cord-302953-gr2kk9w4 379 119 specific specific JJ cord-302953-gr2kk9w4 379 120 CD8 CD8 NNP cord-302953-gr2kk9w4 379 121 + + CC cord-302953-gr2kk9w4 379 122 T t NN cord-302953-gr2kk9w4 379 123 cells cell NNS cord-302953-gr2kk9w4 379 124 by by IN cord-302953-gr2kk9w4 379 125 a a DT cord-302953-gr2kk9w4 379 126 flow flow NN cord-302953-gr2kk9w4 379 127 cytometric cytometric NN cord-302953-gr2kk9w4 379 128 assay assay NN cord-302953-gr2kk9w4 379 129 for for IN cord-302953-gr2kk9w4 379 130 degranulation degranulation NN cord-302953-gr2kk9w4 380 1 Granzyme Granzyme NNP cord-302953-gr2kk9w4 380 2 A A NNP cord-302953-gr2kk9w4 380 3 activates activate VBZ cord-302953-gr2kk9w4 380 4 another another DT cord-302953-gr2kk9w4 380 5 way way NN cord-302953-gr2kk9w4 380 6 to to TO cord-302953-gr2kk9w4 380 7 die die VB cord-302953-gr2kk9w4 380 8 Tissue tissue NN cord-302953-gr2kk9w4 380 9 - - HYPH cord-302953-gr2kk9w4 380 10 resident resident NN cord-302953-gr2kk9w4 380 11 memory memory NN cord-302953-gr2kk9w4 380 12 T T NNP cord-302953-gr2kk9w4 380 13 cells cell NNS cord-302953-gr2kk9w4 381 1 Gamma gamma NN cord-302953-gr2kk9w4 381 2 interferon interferon NN cord-302953-gr2kk9w4 381 3 - - HYPH cord-302953-gr2kk9w4 381 4 dependent dependent JJ cord-302953-gr2kk9w4 381 5 , , , cord-302953-gr2kk9w4 381 6 noncytolytic noncytolytic JJ cord-302953-gr2kk9w4 381 7 clearance clearance NN cord-302953-gr2kk9w4 381 8 of of IN cord-302953-gr2kk9w4 381 9 Sindbis Sindbis NNP cord-302953-gr2kk9w4 381 10 virus virus NN cord-302953-gr2kk9w4 381 11 infection infection NN cord-302953-gr2kk9w4 381 12 from from IN cord-302953-gr2kk9w4 381 13 neurons neuron NNS cord-302953-gr2kk9w4 382 1 in in FW cord-302953-gr2kk9w4 382 2 vitro vitro FW cord-302953-gr2kk9w4 382 3 Autophagy Autophagy NNP cord-302953-gr2kk9w4 382 4 protects protect VBZ cord-302953-gr2kk9w4 382 5 against against IN cord-302953-gr2kk9w4 382 6 Sindbis Sindbis NNP cord-302953-gr2kk9w4 382 7 virus virus NN cord-302953-gr2kk9w4 382 8 infection infection NN cord-302953-gr2kk9w4 382 9 of of IN cord-302953-gr2kk9w4 382 10 the the DT cord-302953-gr2kk9w4 382 11 central central JJ cord-302953-gr2kk9w4 382 12 nervous nervous JJ cord-302953-gr2kk9w4 382 13 system system NN cord-302953-gr2kk9w4 382 14 Eating eat VBG cord-302953-gr2kk9w4 382 15 oneself oneself PRP cord-302953-gr2kk9w4 382 16 and and CC cord-302953-gr2kk9w4 382 17 uninvited uninvited JJ cord-302953-gr2kk9w4 382 18 guests guest NNS cord-302953-gr2kk9w4 382 19 : : : cord-302953-gr2kk9w4 383 1 Autophagy Autophagy NNP cord-302953-gr2kk9w4 383 2 - - HYPH cord-302953-gr2kk9w4 383 3 related relate VBN cord-302953-gr2kk9w4 383 4 pathways pathway NNS cord-302953-gr2kk9w4 383 5 in in IN cord-302953-gr2kk9w4 383 6 cellular cellular JJ cord-302953-gr2kk9w4 383 7 defense defense NN cord-302953-gr2kk9w4 383 8 Autophagy autophagy NN cord-302953-gr2kk9w4 383 9 - - HYPH cord-302953-gr2kk9w4 383 10 dependent dependent JJ cord-302953-gr2kk9w4 383 11 viral viral JJ cord-302953-gr2kk9w4 383 12 recognition recognition NN cord-302953-gr2kk9w4 383 13 by by IN cord-302953-gr2kk9w4 383 14 plasmacytoid plasmacytoid NNP cord-302953-gr2kk9w4 383 15 dendritic dendritic JJ cord-302953-gr2kk9w4 383 16 cells cell NNS cord-302953-gr2kk9w4 383 17 IRGM IRGM NNP cord-302953-gr2kk9w4 383 18 Is be VBZ cord-302953-gr2kk9w4 383 19 a a DT cord-302953-gr2kk9w4 383 20 Common Common NNP cord-302953-gr2kk9w4 383 21 Target Target NNP cord-302953-gr2kk9w4 383 22 of of IN cord-302953-gr2kk9w4 383 23 RNA RNA NNP cord-302953-gr2kk9w4 383 24 Viruses virus NNS cord-302953-gr2kk9w4 383 25 that that WDT cord-302953-gr2kk9w4 383 26 Subvert subvert VBP cord-302953-gr2kk9w4 383 27 the the DT cord-302953-gr2kk9w4 383 28 Autophagy Autophagy NNP cord-302953-gr2kk9w4 383 29 Network Network NNP cord-302953-gr2kk9w4 383 30 Capsid Capsid NNP cord-302953-gr2kk9w4 383 31 , , , cord-302953-gr2kk9w4 383 32 membrane membrane NN cord-302953-gr2kk9w4 383 33 and and CC cord-302953-gr2kk9w4 383 34 NS3 ns3 RB cord-302953-gr2kk9w4 383 35 are be VBP cord-302953-gr2kk9w4 383 36 the the DT cord-302953-gr2kk9w4 383 37 major major JJ cord-302953-gr2kk9w4 383 38 viral viral JJ cord-302953-gr2kk9w4 383 39 proteins protein NNS cord-302953-gr2kk9w4 383 40 involved involve VBN cord-302953-gr2kk9w4 383 41 in in IN cord-302953-gr2kk9w4 383 42 autophagy autophagy NN cord-302953-gr2kk9w4 383 43 induced induce VBN cord-302953-gr2kk9w4 383 44 by by IN cord-302953-gr2kk9w4 383 45 Japanese japanese JJ cord-302953-gr2kk9w4 383 46 encephalitis encephalitis RB cord-302953-gr2kk9w4 383 47 virus virus NN cord-302953-gr2kk9w4 383 48 Common common JJ cord-302953-gr2kk9w4 383 49 host host NN cord-302953-gr2kk9w4 383 50 genes gene NNS cord-302953-gr2kk9w4 383 51 are be VBP cord-302953-gr2kk9w4 383 52 activated activate VBN cord-302953-gr2kk9w4 383 53 in in IN cord-302953-gr2kk9w4 383 54 mouse mouse NN cord-302953-gr2kk9w4 383 55 brain brain NN cord-302953-gr2kk9w4 383 56 by by IN cord-302953-gr2kk9w4 383 57 Japanese japanese JJ cord-302953-gr2kk9w4 383 58 encephalitis encephalitis RB cord-302953-gr2kk9w4 383 59 and and CC cord-302953-gr2kk9w4 383 60 rabies rabies NN cord-302953-gr2kk9w4 383 61 viruses virus NNS cord-302953-gr2kk9w4 384 1 Interferon interferon NN cord-302953-gr2kk9w4 384 2 - - HYPH cord-302953-gr2kk9w4 384 3 stimulated stimulate VBN cord-302953-gr2kk9w4 384 4 genes gene NNS cord-302953-gr2kk9w4 384 5 - - : cord-302953-gr2kk9w4 384 6 Mediators Mediators NNP cord-302953-gr2kk9w4 384 7 of of IN cord-302953-gr2kk9w4 384 8 the the DT cord-302953-gr2kk9w4 384 9 innate innate JJ cord-302953-gr2kk9w4 384 10 immune immune JJ cord-302953-gr2kk9w4 384 11 response response NN cord-302953-gr2kk9w4 384 12 during during IN cord-302953-gr2kk9w4 384 13 canine canine JJ cord-302953-gr2kk9w4 384 14 distemper distemper NN cord-302953-gr2kk9w4 384 15 virus virus NN cord-302953-gr2kk9w4 384 16 infection infection NN cord-302953-gr2kk9w4 384 17 Oas1b oas1b NN cord-302953-gr2kk9w4 384 18 - - HYPH cord-302953-gr2kk9w4 384 19 dependent dependent JJ cord-302953-gr2kk9w4 384 20 immune immune JJ cord-302953-gr2kk9w4 384 21 transcriptional transcriptional JJ cord-302953-gr2kk9w4 384 22 profiles profile NNS cord-302953-gr2kk9w4 384 23 of of IN cord-302953-gr2kk9w4 384 24 West West NNP cord-302953-gr2kk9w4 384 25 Nile Nile NNP cord-302953-gr2kk9w4 384 26 virus virus NN cord-302953-gr2kk9w4 384 27 infection infection NN cord-302953-gr2kk9w4 384 28 in in IN cord-302953-gr2kk9w4 384 29 the the DT cord-302953-gr2kk9w4 384 30 collaborative collaborative JJ cord-302953-gr2kk9w4 384 31 cross cross NN cord-302953-gr2kk9w4 385 1 The the DT cord-302953-gr2kk9w4 385 2 interferon interferon NN cord-302953-gr2kk9w4 385 3 - - HYPH cord-302953-gr2kk9w4 385 4 inducible inducible JJ cord-302953-gr2kk9w4 385 5 protein protein NN cord-302953-gr2kk9w4 385 6 viperin viperin NNP cord-302953-gr2kk9w4 385 7 inhibits inhibit VBZ cord-302953-gr2kk9w4 385 8 influenza influenza NN cord-302953-gr2kk9w4 385 9 virus virus NN cord-302953-gr2kk9w4 385 10 release release NN cord-302953-gr2kk9w4 385 11 by by IN cord-302953-gr2kk9w4 385 12 perturbing perturb VBG cord-302953-gr2kk9w4 385 13 lipid lipid NN cord-302953-gr2kk9w4 385 14 rafts raft NNS cord-302953-gr2kk9w4 385 15 HIV-1 HIV-1 NNP cord-302953-gr2kk9w4 385 16 infection infection NN cord-302953-gr2kk9w4 385 17 of of IN cord-302953-gr2kk9w4 385 18 human human JJ cord-302953-gr2kk9w4 385 19 macrophages macrophage NNS cord-302953-gr2kk9w4 385 20 directly directly RB cord-302953-gr2kk9w4 385 21 induces induce VBZ cord-302953-gr2kk9w4 385 22 viperin viperin NNP cord-302953-gr2kk9w4 385 23 which which WDT cord-302953-gr2kk9w4 385 24 inhibits inhibit VBZ cord-302953-gr2kk9w4 385 25 viral viral JJ cord-302953-gr2kk9w4 385 26 production production NN cord-302953-gr2kk9w4 385 27 In in IN cord-302953-gr2kk9w4 385 28 vivo vivo NN cord-302953-gr2kk9w4 385 29 and and CC cord-302953-gr2kk9w4 385 30 in in IN cord-302953-gr2kk9w4 385 31 vitro vitro FW cord-302953-gr2kk9w4 385 32 studies study NNS cord-302953-gr2kk9w4 385 33 on on IN cord-302953-gr2kk9w4 385 34 the the DT cord-302953-gr2kk9w4 385 35 antiviral antiviral JJ cord-302953-gr2kk9w4 385 36 activities activity NNS cord-302953-gr2kk9w4 385 37 of of IN cord-302953-gr2kk9w4 385 38 viperin viperin NNP cord-302953-gr2kk9w4 385 39 against against IN cord-302953-gr2kk9w4 385 40 influenza influenza NN cord-302953-gr2kk9w4 385 41 H1N1 H1N1 NNP cord-302953-gr2kk9w4 385 42 virus virus NN cord-302953-gr2kk9w4 385 43 infection infection NN cord-302953-gr2kk9w4 386 1 The the DT cord-302953-gr2kk9w4 386 2 antiviral antiviral JJ cord-302953-gr2kk9w4 386 3 protein protein NN cord-302953-gr2kk9w4 386 4 viperin viperin NNP cord-302953-gr2kk9w4 386 5 inhibits inhibit VBZ cord-302953-gr2kk9w4 386 6 hepatitis hepatitis NNP cord-302953-gr2kk9w4 386 7 C C NNP cord-302953-gr2kk9w4 386 8 virus virus NN cord-302953-gr2kk9w4 386 9 replication replication NN cord-302953-gr2kk9w4 386 10 via via IN cord-302953-gr2kk9w4 386 11 interaction interaction NN cord-302953-gr2kk9w4 386 12 with with IN cord-302953-gr2kk9w4 386 13 nonstructural nonstructural JJ cord-302953-gr2kk9w4 386 14 protein protein NN cord-302953-gr2kk9w4 386 15 5A 5a NN cord-302953-gr2kk9w4 386 16 Viperin Viperin NNP cord-302953-gr2kk9w4 386 17 restricts restrict VBZ cord-302953-gr2kk9w4 386 18 chikungunya chikungunya NN cord-302953-gr2kk9w4 386 19 virus virus NN cord-302953-gr2kk9w4 386 20 replication replication NN cord-302953-gr2kk9w4 386 21 and and CC cord-302953-gr2kk9w4 386 22 pathology pathology NN cord-302953-gr2kk9w4 386 23 Cell cell NN cord-302953-gr2kk9w4 386 24 - - HYPH cord-302953-gr2kk9w4 386 25 type type NN cord-302953-gr2kk9w4 386 26 - - HYPH cord-302953-gr2kk9w4 386 27 and and CC cord-302953-gr2kk9w4 386 28 region region NN cord-302953-gr2kk9w4 386 29 - - HYPH cord-302953-gr2kk9w4 386 30 specific specific JJ cord-302953-gr2kk9w4 386 31 restriction restriction NN cord-302953-gr2kk9w4 386 32 of of IN cord-302953-gr2kk9w4 386 33 neurotropic neurotropic NNP cord-302953-gr2kk9w4 386 34 flavivirus flavivirus NNP cord-302953-gr2kk9w4 386 35 infection infection NN cord-302953-gr2kk9w4 386 36 by by IN cord-302953-gr2kk9w4 386 37 viperin viperin NNP cord-302953-gr2kk9w4 386 38 Viperin Viperin NNP cord-302953-gr2kk9w4 386 39 inhibits inhibit VBZ cord-302953-gr2kk9w4 386 40 classical classical JJ cord-302953-gr2kk9w4 386 41 swine swine NN cord-302953-gr2kk9w4 386 42 fever fever NN cord-302953-gr2kk9w4 386 43 virus virus NN cord-302953-gr2kk9w4 386 44 replication replication NN cord-302953-gr2kk9w4 386 45 by by IN cord-302953-gr2kk9w4 386 46 interacting interact VBG cord-302953-gr2kk9w4 386 47 with with IN cord-302953-gr2kk9w4 386 48 viral viral JJ cord-302953-gr2kk9w4 386 49 nonstructural nonstructural JJ cord-302953-gr2kk9w4 386 50 5A 5a NN cord-302953-gr2kk9w4 386 51 protein protein NN cord-302953-gr2kk9w4 386 52 Expression Expression NNP cord-302953-gr2kk9w4 386 53 of of IN cord-302953-gr2kk9w4 386 54 the the DT cord-302953-gr2kk9w4 386 55 zinc zinc NN cord-302953-gr2kk9w4 386 56 - - HYPH cord-302953-gr2kk9w4 386 57 finger finger NN cord-302953-gr2kk9w4 386 58 antiviral antiviral JJ cord-302953-gr2kk9w4 386 59 protein protein NN cord-302953-gr2kk9w4 386 60 inhibits inhibit VBZ cord-302953-gr2kk9w4 387 1 alphavirus alphavirus NNP cord-302953-gr2kk9w4 387 2 replication replication NN cord-302953-gr2kk9w4 387 3 Inhibition Inhibition NNP cord-302953-gr2kk9w4 387 4 of of IN cord-302953-gr2kk9w4 387 5 filovirus filovirus NN cord-302953-gr2kk9w4 387 6 replication replication NN cord-302953-gr2kk9w4 387 7 by by IN cord-302953-gr2kk9w4 387 8 the the DT cord-302953-gr2kk9w4 387 9 zinc zinc NN cord-302953-gr2kk9w4 387 10 finger finger NN cord-302953-gr2kk9w4 387 11 antiviral antiviral JJ cord-302953-gr2kk9w4 387 12 protein protein NN cord-302953-gr2kk9w4 387 13 Zinc Zinc NNP cord-302953-gr2kk9w4 387 14 - - HYPH cord-302953-gr2kk9w4 387 15 finger finger NN cord-302953-gr2kk9w4 387 16 antiviral antiviral JJ cord-302953-gr2kk9w4 387 17 protein protein NN cord-302953-gr2kk9w4 387 18 inhibits inhibit VBZ cord-302953-gr2kk9w4 387 19 HIV-1 HIV-1 NNP cord-302953-gr2kk9w4 387 20 infection infection NN cord-302953-gr2kk9w4 387 21 by by IN cord-302953-gr2kk9w4 387 22 selectively selectively RB cord-302953-gr2kk9w4 387 23 targeting target VBG cord-302953-gr2kk9w4 387 24 multiply multiply VB cord-302953-gr2kk9w4 387 25 spliced splice VBN cord-302953-gr2kk9w4 387 26 viral viral JJ cord-302953-gr2kk9w4 387 27 mRNAs mrna NNS cord-302953-gr2kk9w4 387 28 for for IN cord-302953-gr2kk9w4 387 29 degradation degradation NN cord-302953-gr2kk9w4 387 30 Inhibition inhibition NN cord-302953-gr2kk9w4 387 31 of of IN cord-302953-gr2kk9w4 387 32 hepatitis hepatitis NN cord-302953-gr2kk9w4 387 33 B b NN cord-302953-gr2kk9w4 387 34 virus virus NN cord-302953-gr2kk9w4 387 35 replication replication NN cord-302953-gr2kk9w4 387 36 by by IN cord-302953-gr2kk9w4 387 37 the the DT cord-302953-gr2kk9w4 387 38 host host NN cord-302953-gr2kk9w4 387 39 zinc zinc NN cord-302953-gr2kk9w4 387 40 finger finger NN cord-302953-gr2kk9w4 387 41 antiviral antiviral JJ cord-302953-gr2kk9w4 387 42 protein protein NN cord-302953-gr2kk9w4 387 43 ZAP ZAP NNP cord-302953-gr2kk9w4 387 44 's 's POS cord-302953-gr2kk9w4 387 45 stress stress NN cord-302953-gr2kk9w4 387 46 granule granule NN cord-302953-gr2kk9w4 387 47 localization localization NN cord-302953-gr2kk9w4 387 48 is be VBZ cord-302953-gr2kk9w4 387 49 correlated correlate VBN cord-302953-gr2kk9w4 387 50 with with IN cord-302953-gr2kk9w4 387 51 its -PRON- PRP$ cord-302953-gr2kk9w4 387 52 antiviral antiviral JJ cord-302953-gr2kk9w4 387 53 activity activity NN cord-302953-gr2kk9w4 387 54 and and CC cord-302953-gr2kk9w4 387 55 induced induce VBN cord-302953-gr2kk9w4 387 56 by by IN cord-302953-gr2kk9w4 387 57 virus virus NN cord-302953-gr2kk9w4 387 58 replication replication NN cord-302953-gr2kk9w4 387 59 CD4 CD4 NNP cord-302953-gr2kk9w4 387 60 T T NNP cord-302953-gr2kk9w4 387 61 cells cell NNS cord-302953-gr2kk9w4 387 62 : : : cord-302953-gr2kk9w4 387 63 Fates fate NNS cord-302953-gr2kk9w4 387 64 , , , cord-302953-gr2kk9w4 387 65 functions function NNS cord-302953-gr2kk9w4 387 66 , , , cord-302953-gr2kk9w4 387 67 and and CC cord-302953-gr2kk9w4 387 68 faults fault NNS cord-302953-gr2kk9w4 387 69 Th17 Th17 . cord-302953-gr2kk9w4 388 1 cells cell NNS cord-302953-gr2kk9w4 388 2 enhance enhance VBP cord-302953-gr2kk9w4 388 3 viral viral JJ cord-302953-gr2kk9w4 388 4 persistence persistence NN cord-302953-gr2kk9w4 388 5 and and CC cord-302953-gr2kk9w4 388 6 inhibit inhibit VB cord-302953-gr2kk9w4 388 7 T t NN cord-302953-gr2kk9w4 388 8 cell cell NN cord-302953-gr2kk9w4 388 9 cytotoxicity cytotoxicity NN cord-302953-gr2kk9w4 388 10 in in IN cord-302953-gr2kk9w4 388 11 a a DT cord-302953-gr2kk9w4 388 12 model model NN cord-302953-gr2kk9w4 388 13 of of IN cord-302953-gr2kk9w4 388 14 chronic chronic JJ cord-302953-gr2kk9w4 388 15 virus virus NN cord-302953-gr2kk9w4 388 16 infection infection NN cord-302953-gr2kk9w4 389 1 IL-1 IL-1 NNP cord-302953-gr2kk9w4 389 2 signal signal NN cord-302953-gr2kk9w4 389 3 affects affect VBZ cord-302953-gr2kk9w4 389 4 both both CC cord-302953-gr2kk9w4 389 5 protection protection NN cord-302953-gr2kk9w4 389 6 and and CC cord-302953-gr2kk9w4 389 7 pathogenesis pathogenesis NN cord-302953-gr2kk9w4 389 8 of of IN cord-302953-gr2kk9w4 389 9 virus virus NN cord-302953-gr2kk9w4 389 10 - - HYPH cord-302953-gr2kk9w4 389 11 induced induce VBN cord-302953-gr2kk9w4 389 12 chronic chronic JJ cord-302953-gr2kk9w4 389 13 CNS CNS NNP cord-302953-gr2kk9w4 389 14 demyelinating demyelinate VBG cord-302953-gr2kk9w4 389 15 disease disease NN cord-302953-gr2kk9w4 389 16 IFN IFN NNP cord-302953-gr2kk9w4 389 17 - - HYPH cord-302953-gr2kk9w4 389 18 γ γ NNP cord-302953-gr2kk9w4 389 19 protects protect VBZ cord-302953-gr2kk9w4 389 20 from from IN cord-302953-gr2kk9w4 389 21 lethal lethal JJ cord-302953-gr2kk9w4 389 22 IL-17 IL-17 NNP cord-302953-gr2kk9w4 389 23 mediated mediate VBD cord-302953-gr2kk9w4 389 24 viral viral JJ cord-302953-gr2kk9w4 389 25 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 389 26 independent independent JJ cord-302953-gr2kk9w4 389 27 of of IN cord-302953-gr2kk9w4 389 28 neutrophils neutrophil NNS cord-302953-gr2kk9w4 390 1 Interleukin-17 interleukin-17 IN cord-302953-gr2kk9w4 390 2 : : : cord-302953-gr2kk9w4 391 1 A a DT cord-302953-gr2kk9w4 391 2 novel novel JJ cord-302953-gr2kk9w4 391 3 inflammatory inflammatory JJ cord-302953-gr2kk9w4 391 4 cytokine cytokine NN cord-302953-gr2kk9w4 391 5 that that IN cord-302953-gr2kk9w4 391 6 bridges bridge NNS cord-302953-gr2kk9w4 391 7 innate innate JJ cord-302953-gr2kk9w4 391 8 and and CC cord-302953-gr2kk9w4 391 9 adaptive adaptive JJ cord-302953-gr2kk9w4 391 10 immunity immunity NN cord-302953-gr2kk9w4 391 11 Negative negative JJ cord-302953-gr2kk9w4 391 12 impact impact NN cord-302953-gr2kk9w4 391 13 of of IN cord-302953-gr2kk9w4 391 14 IFN IFN NNP cord-302953-gr2kk9w4 391 15 - - HYPH cord-302953-gr2kk9w4 391 16 γ γ NNP cord-302953-gr2kk9w4 391 17 on on IN cord-302953-gr2kk9w4 391 18 early early JJ cord-302953-gr2kk9w4 391 19 host host NN cord-302953-gr2kk9w4 391 20 immune immune JJ cord-302953-gr2kk9w4 391 21 responses response NNS cord-302953-gr2kk9w4 391 22 to to IN cord-302953-gr2kk9w4 391 23 retroviral retroviral JJ cord-302953-gr2kk9w4 391 24 infection infection NN cord-302953-gr2kk9w4 391 25 Natural natural JJ cord-302953-gr2kk9w4 391 26 killer killer NN cord-302953-gr2kk9w4 391 27 cells cell NNS cord-302953-gr2kk9w4 391 28 appear appear VBP cord-302953-gr2kk9w4 391 29 to to TO cord-302953-gr2kk9w4 391 30 play play VB cord-302953-gr2kk9w4 391 31 no no DT cord-302953-gr2kk9w4 391 32 role role NN cord-302953-gr2kk9w4 391 33 in in IN cord-302953-gr2kk9w4 391 34 the the DT cord-302953-gr2kk9w4 391 35 recovery recovery NN cord-302953-gr2kk9w4 391 36 of of IN cord-302953-gr2kk9w4 391 37 mice mouse NNS cord-302953-gr2kk9w4 391 38 from from IN cord-302953-gr2kk9w4 391 39 Sindbis Sindbis NNP cord-302953-gr2kk9w4 391 40 virus virus NN cord-302953-gr2kk9w4 391 41 infection infection NN cord-302953-gr2kk9w4 391 42 NK NK NNP cord-302953-gr2kk9w4 391 43 cell cell NN cord-302953-gr2kk9w4 391 44 - - HYPH cord-302953-gr2kk9w4 391 45 mediated mediate VBN cord-302953-gr2kk9w4 391 46 immunopathology immunopathology NN cord-302953-gr2kk9w4 391 47 during during IN cord-302953-gr2kk9w4 391 48 an an DT cord-302953-gr2kk9w4 391 49 acute acute JJ cord-302953-gr2kk9w4 391 50 viral viral JJ cord-302953-gr2kk9w4 391 51 infection infection NN cord-302953-gr2kk9w4 391 52 of of IN cord-302953-gr2kk9w4 391 53 the the DT cord-302953-gr2kk9w4 391 54 CNS CNS NNP cord-302953-gr2kk9w4 391 55 Viral Viral NNP cord-302953-gr2kk9w4 391 56 persistence persistence NN cord-302953-gr2kk9w4 391 57 in in IN cord-302953-gr2kk9w4 391 58 neurons neuron NNS cord-302953-gr2kk9w4 391 59 explained explain VBN cord-302953-gr2kk9w4 391 60 by by IN cord-302953-gr2kk9w4 391 61 lack lack NN cord-302953-gr2kk9w4 391 62 of of IN cord-302953-gr2kk9w4 391 63 major major JJ cord-302953-gr2kk9w4 391 64 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 391 65 class class NN cord-302953-gr2kk9w4 392 1 I -PRON- PRP cord-302953-gr2kk9w4 392 2 expression expression NN cord-302953-gr2kk9w4 392 3 Consequences consequence NNS cord-302953-gr2kk9w4 392 4 of of IN cord-302953-gr2kk9w4 392 5 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 392 6 T t NN cord-302953-gr2kk9w4 392 7 lymphocyte lymphocyte NN cord-302953-gr2kk9w4 392 8 interaction interaction NN cord-302953-gr2kk9w4 392 9 with with IN cord-302953-gr2kk9w4 392 10 major major JJ cord-302953-gr2kk9w4 392 11 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 392 12 complex complex JJ cord-302953-gr2kk9w4 392 13 class class NN cord-302953-gr2kk9w4 392 14 I i NN cord-302953-gr2kk9w4 392 15 - - HYPH cord-302953-gr2kk9w4 392 16 expressing express VBG cord-302953-gr2kk9w4 392 17 neurons neuron NNS cord-302953-gr2kk9w4 392 18 in in IN cord-302953-gr2kk9w4 392 19 vivo vivo NNP cord-302953-gr2kk9w4 392 20 Regulation regulation NN cord-302953-gr2kk9w4 392 21 of of IN cord-302953-gr2kk9w4 392 22 class class NN cord-302953-gr2kk9w4 393 1 I -PRON- PRP cord-302953-gr2kk9w4 393 2 MHC MHC NNP cord-302953-gr2kk9w4 393 3 gene gene NN cord-302953-gr2kk9w4 393 4 expression expression NN cord-302953-gr2kk9w4 393 5 in in IN cord-302953-gr2kk9w4 393 6 the the DT cord-302953-gr2kk9w4 393 7 developing develop VBG cord-302953-gr2kk9w4 393 8 and and CC cord-302953-gr2kk9w4 393 9 mature mature VB cord-302953-gr2kk9w4 393 10 CNS CNS NNP cord-302953-gr2kk9w4 393 11 by by IN cord-302953-gr2kk9w4 393 12 neural neural JJ cord-302953-gr2kk9w4 393 13 activity activity NN cord-302953-gr2kk9w4 394 1 Detailed detail VBN cord-302953-gr2kk9w4 394 2 in in IN cord-302953-gr2kk9w4 394 3 vivo vivo NN cord-302953-gr2kk9w4 394 4 analysis analysis NN cord-302953-gr2kk9w4 394 5 of of IN cord-302953-gr2kk9w4 394 6 interferon interferon NN cord-302953-gr2kk9w4 394 7 - - HYPH cord-302953-gr2kk9w4 394 8 gamma gamma NN cord-302953-gr2kk9w4 394 9 induced induce VBN cord-302953-gr2kk9w4 394 10 major major JJ cord-302953-gr2kk9w4 394 11 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 394 12 complex complex JJ cord-302953-gr2kk9w4 394 13 expression expression NN cord-302953-gr2kk9w4 394 14 in in IN cord-302953-gr2kk9w4 394 15 the the DT cord-302953-gr2kk9w4 394 16 central central JJ cord-302953-gr2kk9w4 394 17 nervous nervous JJ cord-302953-gr2kk9w4 394 18 system system NN cord-302953-gr2kk9w4 394 19 : : : cord-302953-gr2kk9w4 394 20 Astrocytes Astrocytes NNPS cord-302953-gr2kk9w4 394 21 fail fail VBP cord-302953-gr2kk9w4 394 22 to to TO cord-302953-gr2kk9w4 394 23 express express VB cord-302953-gr2kk9w4 394 24 major major JJ cord-302953-gr2kk9w4 394 25 histocompatibility histocompatibility NN cord-302953-gr2kk9w4 394 26 complex complex JJ cord-302953-gr2kk9w4 394 27 class class NN cord-302953-gr2kk9w4 394 28 I i NN cord-302953-gr2kk9w4 394 29 and and CC cord-302953-gr2kk9w4 394 30 II II NNP cord-302953-gr2kk9w4 394 31 molecules molecule NNS cord-302953-gr2kk9w4 394 32 Rapid rapid JJ cord-302953-gr2kk9w4 394 33 formation formation NN cord-302953-gr2kk9w4 394 34 of of IN cord-302953-gr2kk9w4 394 35 extended extended JJ cord-302953-gr2kk9w4 394 36 processes process NNS cord-302953-gr2kk9w4 394 37 and and CC cord-302953-gr2kk9w4 394 38 engagement engagement NN cord-302953-gr2kk9w4 394 39 of of IN cord-302953-gr2kk9w4 394 40 Theiler Theiler NNP cord-302953-gr2kk9w4 394 41 's 's POS cord-302953-gr2kk9w4 394 42 virus virus NN cord-302953-gr2kk9w4 394 43 - - HYPH cord-302953-gr2kk9w4 394 44 infected infect VBN cord-302953-gr2kk9w4 394 45 neurons neuron NNS cord-302953-gr2kk9w4 394 46 by by IN cord-302953-gr2kk9w4 394 47 CNS CNS NNP cord-302953-gr2kk9w4 394 48 - - HYPH cord-302953-gr2kk9w4 394 49 infiltrating infiltrate VBG cord-302953-gr2kk9w4 394 50 CD8 CD8 NNP cord-302953-gr2kk9w4 394 51 T T NNP cord-302953-gr2kk9w4 394 52 cells cell NNS cord-302953-gr2kk9w4 394 53 Control Control NNP cord-302953-gr2kk9w4 394 54 of of IN cord-302953-gr2kk9w4 394 55 lymphocytic lymphocytic JJ cord-302953-gr2kk9w4 394 56 choriomeningitis choriomeningitis NNP cord-302953-gr2kk9w4 394 57 virus virus NN cord-302953-gr2kk9w4 394 58 infection infection NN cord-302953-gr2kk9w4 394 59 in in IN cord-302953-gr2kk9w4 395 1 granzyme granzyme NNP cord-302953-gr2kk9w4 395 2 B B NNP cord-302953-gr2kk9w4 395 3 deficient deficient JJ cord-302953-gr2kk9w4 395 4 mice mouse NNS cord-302953-gr2kk9w4 396 1 CD8 CD8 NNP cord-302953-gr2kk9w4 396 2 + + CC cord-302953-gr2kk9w4 396 3 T T NNP cord-302953-gr2kk9w4 396 4 cells cell NNS cord-302953-gr2kk9w4 396 5 require require VBP cord-302953-gr2kk9w4 396 6 perforin perforin NNP cord-302953-gr2kk9w4 396 7 to to TO cord-302953-gr2kk9w4 396 8 clear clear VB cord-302953-gr2kk9w4 396 9 West West NNP cord-302953-gr2kk9w4 396 10 Nile Nile NNP cord-302953-gr2kk9w4 396 11 virus virus NN cord-302953-gr2kk9w4 396 12 from from IN cord-302953-gr2kk9w4 396 13 infected infected JJ cord-302953-gr2kk9w4 396 14 neurons neuron NNS cord-302953-gr2kk9w4 396 15 Cytolytic cytolytic JJ cord-302953-gr2kk9w4 396 16 effector effector NN cord-302953-gr2kk9w4 396 17 pathways pathway NNS cord-302953-gr2kk9w4 396 18 and and CC cord-302953-gr2kk9w4 396 19 IFN IFN NNP cord-302953-gr2kk9w4 396 20 - - HYPH cord-302953-gr2kk9w4 396 21 γ γ NN cord-302953-gr2kk9w4 396 22 help help NN cord-302953-gr2kk9w4 396 23 protect protect VB cord-302953-gr2kk9w4 396 24 against against IN cord-302953-gr2kk9w4 396 25 Japanese japanese JJ cord-302953-gr2kk9w4 396 26 encephalitis encephalitis NN cord-302953-gr2kk9w4 396 27 Perforin Perforin NNP cord-302953-gr2kk9w4 396 28 - - HYPH cord-302953-gr2kk9w4 396 29 mediated mediate VBN cord-302953-gr2kk9w4 396 30 effector effector NN cord-302953-gr2kk9w4 396 31 function function NN cord-302953-gr2kk9w4 396 32 within within IN cord-302953-gr2kk9w4 396 33 the the DT cord-302953-gr2kk9w4 396 34 central central JJ cord-302953-gr2kk9w4 396 35 nervous nervous JJ cord-302953-gr2kk9w4 396 36 system system NN cord-302953-gr2kk9w4 396 37 requires require VBZ cord-302953-gr2kk9w4 396 38 IFN IFN NNP cord-302953-gr2kk9w4 396 39 - - HYPH cord-302953-gr2kk9w4 396 40 γ γ NNP cord-302953-gr2kk9w4 396 41 mediated mediate VBD cord-302953-gr2kk9w4 396 42 MHC MHC NNP cord-302953-gr2kk9w4 396 43 up up IN cord-302953-gr2kk9w4 396 44 - - HYPH cord-302953-gr2kk9w4 396 45 regulation regulation NN cord-302953-gr2kk9w4 397 1 The the DT cord-302953-gr2kk9w4 397 2 critical critical JJ cord-302953-gr2kk9w4 397 3 role role NN cord-302953-gr2kk9w4 397 4 of of IN cord-302953-gr2kk9w4 397 5 IFN IFN NNP cord-302953-gr2kk9w4 397 6 - - HYPH cord-302953-gr2kk9w4 397 7 γ γ NNP cord-302953-gr2kk9w4 397 8 in in IN cord-302953-gr2kk9w4 397 9 experimental experimental JJ cord-302953-gr2kk9w4 397 10 coronavirus coronavirus NN cord-302953-gr2kk9w4 397 11 retinopathy retinopathy NN cord-302953-gr2kk9w4 397 12 Are be VBP cord-302953-gr2kk9w4 397 13 proteinases proteinases NNP cord-302953-gr2kk9w4 397 14 functional functional JJ cord-302953-gr2kk9w4 397 15 molecules molecule NNS cord-302953-gr2kk9w4 397 16 of of IN cord-302953-gr2kk9w4 397 17 T t NN cord-302953-gr2kk9w4 397 18 lymphocytes lymphocyte NNS cord-302953-gr2kk9w4 397 19 ? ? . cord-302953-gr2kk9w4 398 1 Human human JJ cord-302953-gr2kk9w4 398 2 and and CC cord-302953-gr2kk9w4 398 3 mouse mouse NN cord-302953-gr2kk9w4 398 4 granzyme granzyme NNS cord-302953-gr2kk9w4 398 5 A a DT cord-302953-gr2kk9w4 398 6 induce induce VBP cord-302953-gr2kk9w4 398 7 a a DT cord-302953-gr2kk9w4 398 8 proinflammatory proinflammatory JJ cord-302953-gr2kk9w4 398 9 cytokine cytokine NN cord-302953-gr2kk9w4 398 10 response response NN cord-302953-gr2kk9w4 398 11 Granzyme Granzyme NNP cord-302953-gr2kk9w4 398 12 B b NN cord-302953-gr2kk9w4 398 13 - - HYPH cord-302953-gr2kk9w4 398 14 dependent dependent JJ cord-302953-gr2kk9w4 398 15 proteolysis proteolysis NN cord-302953-gr2kk9w4 398 16 acts act VBZ cord-302953-gr2kk9w4 398 17 as as IN cord-302953-gr2kk9w4 398 18 a a DT cord-302953-gr2kk9w4 398 19 switch switch NN cord-302953-gr2kk9w4 398 20 to to TO cord-302953-gr2kk9w4 398 21 enhance enhance VB cord-302953-gr2kk9w4 398 22 the the DT cord-302953-gr2kk9w4 398 23 proinflammatory proinflammatory JJ cord-302953-gr2kk9w4 398 24 activity activity NN cord-302953-gr2kk9w4 398 25 of of IN cord-302953-gr2kk9w4 398 26 IL-1α IL-1α NNP cord-302953-gr2kk9w4 398 27 Gamma Gamma NNP cord-302953-gr2kk9w4 398 28 interferon interferon NN cord-302953-gr2kk9w4 399 1 can can MD cord-302953-gr2kk9w4 399 2 block block VB cord-302953-gr2kk9w4 399 3 herpes herpes NN cord-302953-gr2kk9w4 399 4 simplex simplex NNP cord-302953-gr2kk9w4 399 5 virus virus NN cord-302953-gr2kk9w4 399 6 type type NN cord-302953-gr2kk9w4 399 7 1 1 CD cord-302953-gr2kk9w4 399 8 reactivation reactivation NN cord-302953-gr2kk9w4 399 9 from from IN cord-302953-gr2kk9w4 399 10 latency latency NNP cord-302953-gr2kk9w4 399 11 , , , cord-302953-gr2kk9w4 399 12 even even RB cord-302953-gr2kk9w4 399 13 in in IN cord-302953-gr2kk9w4 399 14 the the DT cord-302953-gr2kk9w4 399 15 presence presence NN cord-302953-gr2kk9w4 399 16 of of IN cord-302953-gr2kk9w4 399 17 late late JJ cord-302953-gr2kk9w4 399 18 gene gene NN cord-302953-gr2kk9w4 399 19 expression expression NN cord-302953-gr2kk9w4 399 20 Selective selective JJ cord-302953-gr2kk9w4 399 21 retention retention NN cord-302953-gr2kk9w4 399 22 of of IN cord-302953-gr2kk9w4 399 23 herpes herpes NNP cord-302953-gr2kk9w4 399 24 simplex simplex NNP cord-302953-gr2kk9w4 399 25 virus virus NN cord-302953-gr2kk9w4 399 26 - - HYPH cord-302953-gr2kk9w4 399 27 specific specific JJ cord-302953-gr2kk9w4 399 28 T t NN cord-302953-gr2kk9w4 399 29 cells cell NNS cord-302953-gr2kk9w4 399 30 in in IN cord-302953-gr2kk9w4 399 31 latently latently RB cord-302953-gr2kk9w4 399 32 infected infect VBN cord-302953-gr2kk9w4 399 33 human human JJ cord-302953-gr2kk9w4 399 34 trigeminal trigeminal NN cord-302953-gr2kk9w4 399 35 ganglia ganglion NNS cord-302953-gr2kk9w4 399 36 Noncytotoxic Noncytotoxic NNP cord-302953-gr2kk9w4 399 37 lytic lytic JJ cord-302953-gr2kk9w4 399 38 granule granule NN cord-302953-gr2kk9w4 399 39 - - HYPH cord-302953-gr2kk9w4 399 40 mediated mediate VBN cord-302953-gr2kk9w4 399 41 CD8 CD8 NNP cord-302953-gr2kk9w4 399 42 + + CC cord-302953-gr2kk9w4 399 43 T T NNP cord-302953-gr2kk9w4 399 44 cell cell NN cord-302953-gr2kk9w4 399 45 inhibition inhibition NN cord-302953-gr2kk9w4 399 46 of of IN cord-302953-gr2kk9w4 399 47 HSV-1 HSV-1 NNP cord-302953-gr2kk9w4 399 48 reactivation reactivation NN cord-302953-gr2kk9w4 399 49 from from IN cord-302953-gr2kk9w4 399 50 neuronal neuronal JJ cord-302953-gr2kk9w4 399 51 latency latency NN cord-302953-gr2kk9w4 399 52 Mouse mouse NN cord-302953-gr2kk9w4 399 53 granzyme granzyme NNS cord-302953-gr2kk9w4 400 1 K K NNP cord-302953-gr2kk9w4 400 2 has have VBZ cord-302953-gr2kk9w4 400 3 pro pro JJ cord-302953-gr2kk9w4 400 4 - - JJ cord-302953-gr2kk9w4 400 5 inflammatory inflammatory JJ cord-302953-gr2kk9w4 400 6 potential potential NN cord-302953-gr2kk9w4 400 7 A a DT cord-302953-gr2kk9w4 400 8 secretable secretable JJ cord-302953-gr2kk9w4 400 9 serine serine NN cord-302953-gr2kk9w4 400 10 proteinase proteinase NN cord-302953-gr2kk9w4 400 11 with with IN cord-302953-gr2kk9w4 400 12 highly highly RB cord-302953-gr2kk9w4 400 13 restricted restrict VBN cord-302953-gr2kk9w4 400 14 specificity specificity NN cord-302953-gr2kk9w4 400 15 from from IN cord-302953-gr2kk9w4 400 16 cytolytic cytolytic JJ cord-302953-gr2kk9w4 400 17 T t NN cord-302953-gr2kk9w4 400 18 lymphocytes lymphocyte NNS cord-302953-gr2kk9w4 400 19 inactivates inactivate VBZ cord-302953-gr2kk9w4 400 20 retrovirus retrovirus NN cord-302953-gr2kk9w4 400 21 - - HYPH cord-302953-gr2kk9w4 400 22 associated associate VBN cord-302953-gr2kk9w4 400 23 reverse reverse NN cord-302953-gr2kk9w4 400 24 transcriptase transcriptase NN cord-302953-gr2kk9w4 400 25 Granzyme Granzyme NNP cord-302953-gr2kk9w4 400 26 H H NNP cord-302953-gr2kk9w4 400 27 destroys destroy VBZ cord-302953-gr2kk9w4 400 28 the the DT cord-302953-gr2kk9w4 400 29 function function NN cord-302953-gr2kk9w4 400 30 of of IN cord-302953-gr2kk9w4 400 31 critical critical JJ cord-302953-gr2kk9w4 400 32 adenoviral adenoviral JJ cord-302953-gr2kk9w4 400 33 proteins protein NNS cord-302953-gr2kk9w4 400 34 required require VBN cord-302953-gr2kk9w4 400 35 for for IN cord-302953-gr2kk9w4 400 36 viral viral JJ cord-302953-gr2kk9w4 400 37 DNA dna NN cord-302953-gr2kk9w4 400 38 replication replication NN cord-302953-gr2kk9w4 400 39 and and CC cord-302953-gr2kk9w4 400 40 granzyme granzyme NNS cord-302953-gr2kk9w4 400 41 B B NNP cord-302953-gr2kk9w4 400 42 inhibition inhibition NN cord-302953-gr2kk9w4 400 43 Granzyme Granzyme NNP cord-302953-gr2kk9w4 400 44 M M NNP cord-302953-gr2kk9w4 400 45 targets target NNS cord-302953-gr2kk9w4 400 46 host host NN cord-302953-gr2kk9w4 400 47 cell cell NN cord-302953-gr2kk9w4 400 48 hnRNP hnrnp NN cord-302953-gr2kk9w4 401 1 K K NNP cord-302953-gr2kk9w4 401 2 that that WDT cord-302953-gr2kk9w4 401 3 is be VBZ cord-302953-gr2kk9w4 401 4 essential essential JJ cord-302953-gr2kk9w4 401 5 for for IN cord-302953-gr2kk9w4 401 6 human human JJ cord-302953-gr2kk9w4 401 7 cytomegalovirus cytomegalovirus NN cord-302953-gr2kk9w4 401 8 replication replication NN cord-302953-gr2kk9w4 401 9 Functional functional JJ cord-302953-gr2kk9w4 401 10 characterization characterization NN cord-302953-gr2kk9w4 401 11 of of IN cord-302953-gr2kk9w4 401 12 the the DT cord-302953-gr2kk9w4 401 13 interaction interaction NN cord-302953-gr2kk9w4 401 14 between between IN cord-302953-gr2kk9w4 401 15 human human NN cord-302953-gr2kk9w4 401 16 La La NNP cord-302953-gr2kk9w4 401 17 and and CC cord-302953-gr2kk9w4 401 18 hepatitis hepatitis NNP cord-302953-gr2kk9w4 401 19 B B NNP cord-302953-gr2kk9w4 401 20 virus virus NN cord-302953-gr2kk9w4 401 21 RNA RNA NNP cord-302953-gr2kk9w4 401 22 Cleavage Cleavage NNP cord-302953-gr2kk9w4 401 23 of of IN cord-302953-gr2kk9w4 401 24 La La NNP cord-302953-gr2kk9w4 401 25 protein protein NN cord-302953-gr2kk9w4 401 26 by by IN cord-302953-gr2kk9w4 401 27 granzyme granzyme NNS cord-302953-gr2kk9w4 401 28 H H NNP cord-302953-gr2kk9w4 401 29 induces induce VBZ cord-302953-gr2kk9w4 401 30 cytoplasmic cytoplasmic JJ cord-302953-gr2kk9w4 401 31 translocation translocation NN cord-302953-gr2kk9w4 401 32 and and CC cord-302953-gr2kk9w4 401 33 interferes interfere VBZ cord-302953-gr2kk9w4 401 34 with with IN cord-302953-gr2kk9w4 401 35 La La NNP cord-302953-gr2kk9w4 401 36 - - HYPH cord-302953-gr2kk9w4 401 37 mediated mediate VBN cord-302953-gr2kk9w4 401 38 HCV HCV NNP cord-302953-gr2kk9w4 401 39 - - HYPH cord-302953-gr2kk9w4 401 40 IRES ires JJ cord-302953-gr2kk9w4 401 41 translational translational JJ cord-302953-gr2kk9w4 401 42 activity activity NN cord-302953-gr2kk9w4 401 43 La La NNP cord-302953-gr2kk9w4 401 44 protein protein NN cord-302953-gr2kk9w4 401 45 binds bind VBZ cord-302953-gr2kk9w4 401 46 the the DT cord-302953-gr2kk9w4 401 47 predicted predict VBN cord-302953-gr2kk9w4 401 48 loop loop NN cord-302953-gr2kk9w4 401 49 structures structure NNS cord-302953-gr2kk9w4 401 50 in in IN cord-302953-gr2kk9w4 401 51 the the DT cord-302953-gr2kk9w4 401 52 3 3 CD cord-302953-gr2kk9w4 401 53 ' ' `` cord-302953-gr2kk9w4 401 54 non non JJ cord-302953-gr2kk9w4 401 55 - - JJ cord-302953-gr2kk9w4 401 56 coding coding JJ cord-302953-gr2kk9w4 401 57 region region NN cord-302953-gr2kk9w4 401 58 of of IN cord-302953-gr2kk9w4 401 59 Japanese japanese JJ cord-302953-gr2kk9w4 401 60 encephalitis encephalitis RB cord-302953-gr2kk9w4 401 61 virus virus NN cord-302953-gr2kk9w4 401 62 genome genome NN cord-302953-gr2kk9w4 401 63 : : : cord-302953-gr2kk9w4 402 1 Role role NN cord-302953-gr2kk9w4 402 2 in in IN cord-302953-gr2kk9w4 402 3 virus virus NN cord-302953-gr2kk9w4 402 4 replication replication NN cord-302953-gr2kk9w4 402 5 La La NNP cord-302953-gr2kk9w4 402 6 Protein Protein NNP cord-302953-gr2kk9w4 402 7 can can MD cord-302953-gr2kk9w4 402 8 simultaneously simultaneously RB cord-302953-gr2kk9w4 402 9 bind bind VB cord-302953-gr2kk9w4 402 10 to to IN cord-302953-gr2kk9w4 403 1 both both DT cord-302953-gr2kk9w4 403 2 3 3 CD cord-302953-gr2kk9w4 403 3 -and -and SYM cord-302953-gr2kk9w4 403 4 5 5 CD cord-302953-gr2kk9w4 403 5 -noncoding -noncoding NN cord-302953-gr2kk9w4 403 6 regions region NNS cord-302953-gr2kk9w4 403 7 of of IN cord-302953-gr2kk9w4 403 8 Japanese japanese JJ cord-302953-gr2kk9w4 403 9 encephalitis encephalitis RB cord-302953-gr2kk9w4 403 10 virus virus NN cord-302953-gr2kk9w4 403 11 genome genome NN cord-302953-gr2kk9w4 403 12 Heterogeneous heterogeneous JJ cord-302953-gr2kk9w4 403 13 nuclear nuclear JJ cord-302953-gr2kk9w4 403 14 ribonuclear ribonuclear NN cord-302953-gr2kk9w4 403 15 protein protein NN cord-302953-gr2kk9w4 403 16 K K NNP cord-302953-gr2kk9w4 403 17 interacts interact VBZ cord-302953-gr2kk9w4 403 18 with with IN cord-302953-gr2kk9w4 403 19 the the DT cord-302953-gr2kk9w4 403 20 enterovirus enterovirus NN cord-302953-gr2kk9w4 403 21 71 71 CD cord-302953-gr2kk9w4 403 22 5 5 CD cord-302953-gr2kk9w4 403 23 ' ' POS cord-302953-gr2kk9w4 403 24 untranslated untranslated JJ cord-302953-gr2kk9w4 403 25 region region NN cord-302953-gr2kk9w4 403 26 and and CC cord-302953-gr2kk9w4 403 27 participates participate VBZ cord-302953-gr2kk9w4 403 28 in in IN cord-302953-gr2kk9w4 403 29 virus virus NN cord-302953-gr2kk9w4 403 30 replication replication NN cord-302953-gr2kk9w4 404 1 HIV HIV NNP cord-302953-gr2kk9w4 404 2 Nef Nef NNP cord-302953-gr2kk9w4 404 3 enhances enhance VBZ cord-302953-gr2kk9w4 404 4 Tat Tat NNP cord-302953-gr2kk9w4 404 5 - - HYPH cord-302953-gr2kk9w4 404 6 mediated mediate VBN cord-302953-gr2kk9w4 404 7 viral viral JJ cord-302953-gr2kk9w4 404 8 transcription transcription NN cord-302953-gr2kk9w4 404 9 through through IN cord-302953-gr2kk9w4 404 10 a a DT cord-302953-gr2kk9w4 404 11 hnRNP hnrnp NN cord-302953-gr2kk9w4 404 12 - - HYPH cord-302953-gr2kk9w4 404 13 K k NN cord-302953-gr2kk9w4 404 14 - - HYPH cord-302953-gr2kk9w4 404 15 nucleated nucleated JJ cord-302953-gr2kk9w4 404 16 signaling signal VBG cord-302953-gr2kk9w4 404 17 complex complex JJ cord-302953-gr2kk9w4 404 18 Vimentin Vimentin NNP cord-302953-gr2kk9w4 404 19 interacts interact VBZ cord-302953-gr2kk9w4 404 20 with with IN cord-302953-gr2kk9w4 404 21 heterogeneous heterogeneous JJ cord-302953-gr2kk9w4 404 22 nuclear nuclear JJ cord-302953-gr2kk9w4 404 23 ribonucleoproteins ribonucleoprotein NNS cord-302953-gr2kk9w4 404 24 and and CC cord-302953-gr2kk9w4 404 25 dengue dengue NN cord-302953-gr2kk9w4 404 26 nonstructural nonstructural JJ cord-302953-gr2kk9w4 404 27 protein protein NN cord-302953-gr2kk9w4 404 28 1 1 CD cord-302953-gr2kk9w4 404 29 and and CC cord-302953-gr2kk9w4 404 30 is be VBZ cord-302953-gr2kk9w4 404 31 important important JJ cord-302953-gr2kk9w4 404 32 for for IN cord-302953-gr2kk9w4 404 33 viral viral JJ cord-302953-gr2kk9w4 404 34 replication replication NN cord-302953-gr2kk9w4 404 35 and and CC cord-302953-gr2kk9w4 404 36 release release NN cord-302953-gr2kk9w4 404 37 Mapping mapping NN cord-302953-gr2kk9w4 404 38 of of IN cord-302953-gr2kk9w4 404 39 chikungunya chikungunya NN cord-302953-gr2kk9w4 404 40 virus virus NN cord-302953-gr2kk9w4 404 41 interactions interaction NNS cord-302953-gr2kk9w4 404 42 with with IN cord-302953-gr2kk9w4 404 43 host host NN cord-302953-gr2kk9w4 404 44 proteins protein NNS cord-302953-gr2kk9w4 404 45 identified identify VBN cord-302953-gr2kk9w4 404 46 nsP2 nsp2 CC cord-302953-gr2kk9w4 404 47 as as IN cord-302953-gr2kk9w4 404 48 a a DT cord-302953-gr2kk9w4 404 49 highly highly RB cord-302953-gr2kk9w4 404 50 connected connect VBN cord-302953-gr2kk9w4 404 51 viral viral JJ cord-302953-gr2kk9w4 404 52 component component NN cord-302953-gr2kk9w4 404 53 Heterogeneous heterogeneous JJ cord-302953-gr2kk9w4 404 54 nuclear nuclear JJ cord-302953-gr2kk9w4 404 55 ribonuclear ribonuclear NN cord-302953-gr2kk9w4 404 56 protein protein NN cord-302953-gr2kk9w4 404 57 K K NNP cord-302953-gr2kk9w4 404 58 interacts interact VBZ cord-302953-gr2kk9w4 404 59 with with IN cord-302953-gr2kk9w4 404 60 Sindbis Sindbis NNP cord-302953-gr2kk9w4 404 61 virus virus NN cord-302953-gr2kk9w4 404 62 nonstructural nonstructural JJ cord-302953-gr2kk9w4 404 63 proteins protein NNS cord-302953-gr2kk9w4 404 64 and and CC cord-302953-gr2kk9w4 404 65 viral viral JJ cord-302953-gr2kk9w4 404 66 subgenomic subgenomic NNP cord-302953-gr2kk9w4 405 1 mRNA mRNA NNP cord-302953-gr2kk9w4 405 2 Identification identification NN cord-302953-gr2kk9w4 405 3 and and CC cord-302953-gr2kk9w4 405 4 characterization characterization NN cord-302953-gr2kk9w4 405 5 of of IN cord-302953-gr2kk9w4 405 6 Sindbis Sindbis NNP cord-302953-gr2kk9w4 405 7 virus virus NN cord-302953-gr2kk9w4 405 8 RNA rna NN cord-302953-gr2kk9w4 405 9 - - HYPH cord-302953-gr2kk9w4 405 10 host host NN cord-302953-gr2kk9w4 405 11 protein protein NN cord-302953-gr2kk9w4 405 12 interactions interaction NNS cord-302953-gr2kk9w4 405 13 Magnetic magnetic JJ cord-302953-gr2kk9w4 405 14 fractionation fractionation NN cord-302953-gr2kk9w4 405 15 and and CC cord-302953-gr2kk9w4 405 16 proteomic proteomic JJ cord-302953-gr2kk9w4 405 17 dissection dissection NN cord-302953-gr2kk9w4 405 18 of of IN cord-302953-gr2kk9w4 405 19 cellular cellular JJ cord-302953-gr2kk9w4 405 20 organelles organelle NNS cord-302953-gr2kk9w4 405 21 occupied occupy VBN cord-302953-gr2kk9w4 405 22 by by IN cord-302953-gr2kk9w4 405 23 the the DT cord-302953-gr2kk9w4 405 24 late late JJ cord-302953-gr2kk9w4 405 25 replication replication NN cord-302953-gr2kk9w4 405 26 complexes complex NNS cord-302953-gr2kk9w4 405 27 of of IN cord-302953-gr2kk9w4 405 28 Semliki Semliki NNP cord-302953-gr2kk9w4 405 29 Forest Forest NNP cord-302953-gr2kk9w4 405 30 virus virus NN cord-302953-gr2kk9w4 406 1 Long long JJ cord-302953-gr2kk9w4 406 2 term term NN cord-302953-gr2kk9w4 406 3 intraparenchymal intraparenchymal JJ cord-302953-gr2kk9w4 406 4 Ig ig JJ cord-302953-gr2kk9w4 406 5 secretion secretion NN cord-302953-gr2kk9w4 406 6 after after IN cord-302953-gr2kk9w4 406 7 acute acute JJ cord-302953-gr2kk9w4 406 8 viral viral JJ cord-302953-gr2kk9w4 406 9 encephalitis encephalitis RB cord-302953-gr2kk9w4 406 10 in in IN cord-302953-gr2kk9w4 406 11 mice mouse NNS cord-302953-gr2kk9w4 406 12 Persistence persistence NN cord-302953-gr2kk9w4 406 13 of of IN cord-302953-gr2kk9w4 406 14 Japanese japanese JJ cord-302953-gr2kk9w4 406 15 encephalitis encephalitis RB cord-302953-gr2kk9w4 406 16 virus virus NN cord-302953-gr2kk9w4 406 17 in in IN cord-302953-gr2kk9w4 406 18 the the DT cord-302953-gr2kk9w4 406 19 human human JJ cord-302953-gr2kk9w4 406 20 nervous nervous JJ cord-302953-gr2kk9w4 406 21 system system NN cord-302953-gr2kk9w4 406 22 Long long JJ cord-302953-gr2kk9w4 406 23 - - HYPH cord-302953-gr2kk9w4 406 24 term term NN cord-302953-gr2kk9w4 406 25 effects effect NNS cord-302953-gr2kk9w4 406 26 of of IN cord-302953-gr2kk9w4 406 27 Semliki Semliki NNP cord-302953-gr2kk9w4 406 28 Forest Forest NNP cord-302953-gr2kk9w4 406 29 virus virus NN cord-302953-gr2kk9w4 406 30 infection infection NN cord-302953-gr2kk9w4 406 31 in in IN cord-302953-gr2kk9w4 406 32 the the DT cord-302953-gr2kk9w4 406 33 mouse mouse NN cord-302953-gr2kk9w4 406 34 central central JJ cord-302953-gr2kk9w4 406 35 nervous nervous JJ cord-302953-gr2kk9w4 406 36 system system NN cord-302953-gr2kk9w4 406 37 Persistence Persistence NNP cord-302953-gr2kk9w4 406 38 of of IN cord-302953-gr2kk9w4 406 39 West West NNP cord-302953-gr2kk9w4 406 40 Nile Nile NNP cord-302953-gr2kk9w4 406 41 virus virus NN cord-302953-gr2kk9w4 406 42 in in IN cord-302953-gr2kk9w4 406 43 the the DT cord-302953-gr2kk9w4 406 44 central central JJ cord-302953-gr2kk9w4 406 45 nervous nervous JJ cord-302953-gr2kk9w4 406 46 system system NN cord-302953-gr2kk9w4 406 47 and and CC cord-302953-gr2kk9w4 406 48 periphery periphery NN cord-302953-gr2kk9w4 406 49 of of IN cord-302953-gr2kk9w4 406 50 mice mouse NNS cord-302953-gr2kk9w4 406 51 T T NNP cord-302953-gr2kk9w4 406 52 cells cell NNS cord-302953-gr2kk9w4 406 53 facilitate facilitate VBP cord-302953-gr2kk9w4 406 54 recovery recovery NN cord-302953-gr2kk9w4 406 55 from from IN cord-302953-gr2kk9w4 406 56 Venezuelan venezuelan JJ cord-302953-gr2kk9w4 406 57 equine equine NN cord-302953-gr2kk9w4 406 58 encephalitis encephalitis NN cord-302953-gr2kk9w4 406 59 virus virus NN cord-302953-gr2kk9w4 406 60 - - HYPH cord-302953-gr2kk9w4 406 61 induced induce VBN cord-302953-gr2kk9w4 406 62 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 406 63 in in IN cord-302953-gr2kk9w4 406 64 the the DT cord-302953-gr2kk9w4 406 65 absence absence NN cord-302953-gr2kk9w4 406 66 of of IN cord-302953-gr2kk9w4 406 67 antibody antibody NN cord-302953-gr2kk9w4 406 68 Persistence persistence NN cord-302953-gr2kk9w4 406 69 of of IN cord-302953-gr2kk9w4 406 70 virus virus NN cord-302953-gr2kk9w4 406 71 - - HYPH cord-302953-gr2kk9w4 406 72 specific specific JJ cord-302953-gr2kk9w4 406 73 immune immune JJ cord-302953-gr2kk9w4 406 74 responses response NNS cord-302953-gr2kk9w4 406 75 in in IN cord-302953-gr2kk9w4 406 76 the the DT cord-302953-gr2kk9w4 406 77 central central JJ cord-302953-gr2kk9w4 406 78 nervous nervous JJ cord-302953-gr2kk9w4 406 79 system system NN cord-302953-gr2kk9w4 406 80 of of IN cord-302953-gr2kk9w4 406 81 mice mouse NNS cord-302953-gr2kk9w4 406 82 after after IN cord-302953-gr2kk9w4 406 83 West West NNP cord-302953-gr2kk9w4 406 84 Nile Nile NNP cord-302953-gr2kk9w4 406 85 virus virus NN cord-302953-gr2kk9w4 406 86 infection infection NN cord-302953-gr2kk9w4 406 87 Recruitment recruitment NN cord-302953-gr2kk9w4 406 88 and and CC cord-302953-gr2kk9w4 406 89 retention retention NN cord-302953-gr2kk9w4 406 90 of of IN cord-302953-gr2kk9w4 406 91 B B NNP cord-302953-gr2kk9w4 406 92 Cells cell NNS cord-302953-gr2kk9w4 406 93 in in IN cord-302953-gr2kk9w4 406 94 the the DT cord-302953-gr2kk9w4 406 95 central central JJ cord-302953-gr2kk9w4 406 96 nervous nervous JJ cord-302953-gr2kk9w4 406 97 system system NN cord-302953-gr2kk9w4 406 98 in in IN cord-302953-gr2kk9w4 406 99 response response NN cord-302953-gr2kk9w4 406 100 to to IN cord-302953-gr2kk9w4 406 101 alphavirus alphavirus NNP cord-302953-gr2kk9w4 406 102 encephalomyelitis encephalomyelitis NN cord-302953-gr2kk9w4 406 103 Dendritic dendritic JJ cord-302953-gr2kk9w4 406 104 cell cell NN cord-302953-gr2kk9w4 406 105 - - HYPH cord-302953-gr2kk9w4 406 106 induced induce VBN cord-302953-gr2kk9w4 406 107 memory memory NN cord-302953-gr2kk9w4 406 108 T T NNP cord-302953-gr2kk9w4 406 109 cell cell NN cord-302953-gr2kk9w4 406 110 activation activation NN cord-302953-gr2kk9w4 406 111 in in IN cord-302953-gr2kk9w4 406 112 nonlymphoid nonlymphoid NNP cord-302953-gr2kk9w4 406 113 tissues tissue NNS cord-302953-gr2kk9w4 406 114 Long long RB cord-302953-gr2kk9w4 406 115 - - HYPH cord-302953-gr2kk9w4 406 116 lived live VBN cord-302953-gr2kk9w4 406 117 epithelial epithelial JJ cord-302953-gr2kk9w4 406 118 immunity immunity NN cord-302953-gr2kk9w4 406 119 by by IN cord-302953-gr2kk9w4 406 120 tissue tissue NN cord-302953-gr2kk9w4 406 121 - - HYPH cord-302953-gr2kk9w4 406 122 resident resident NN cord-302953-gr2kk9w4 406 123 memory memory NN cord-302953-gr2kk9w4 406 124 T T NNP cord-302953-gr2kk9w4 406 125 ( ( -LRB- cord-302953-gr2kk9w4 406 126 TRM TRM NNP cord-302953-gr2kk9w4 406 127 ) ) -RRB- cord-302953-gr2kk9w4 406 128 cells cell NNS cord-302953-gr2kk9w4 406 129 in in IN cord-302953-gr2kk9w4 406 130 the the DT cord-302953-gr2kk9w4 406 131 absence absence NN cord-302953-gr2kk9w4 406 132 of of IN cord-302953-gr2kk9w4 406 133 persisting persist VBG cord-302953-gr2kk9w4 406 134 local local JJ cord-302953-gr2kk9w4 406 135 antigen antigen NN cord-302953-gr2kk9w4 406 136 presentation presentation NN cord-302953-gr2kk9w4 406 137 Brain Brain NNP cord-302953-gr2kk9w4 406 138 - - HYPH cord-302953-gr2kk9w4 406 139 resident resident NN cord-302953-gr2kk9w4 406 140 memory memory NN cord-302953-gr2kk9w4 406 141 T T NNP cord-302953-gr2kk9w4 406 142 cells cell NNS cord-302953-gr2kk9w4 406 143 represent represent VBP cord-302953-gr2kk9w4 406 144 an an DT cord-302953-gr2kk9w4 406 145 autonomous autonomous JJ cord-302953-gr2kk9w4 406 146 cytotoxic cytotoxic JJ cord-302953-gr2kk9w4 406 147 barrier barrier NN cord-302953-gr2kk9w4 406 148 to to IN cord-302953-gr2kk9w4 406 149 viral viral JJ cord-302953-gr2kk9w4 406 150 infection infection NN cord-302953-gr2kk9w4 407 1 CD4 CD4 NNP cord-302953-gr2kk9w4 407 2 + + CC cord-302953-gr2kk9w4 407 3 T T NNP cord-302953-gr2kk9w4 407 4 cell cell NN cord-302953-gr2kk9w4 407 5 help help NN cord-302953-gr2kk9w4 407 6 guides guide VBZ cord-302953-gr2kk9w4 407 7 formation formation NN cord-302953-gr2kk9w4 407 8 of of IN cord-302953-gr2kk9w4 407 9 CD103 CD103 NNP cord-302953-gr2kk9w4 407 10 + + CC cord-302953-gr2kk9w4 407 11 lung lung NN cord-302953-gr2kk9w4 407 12 - - HYPH cord-302953-gr2kk9w4 407 13 resident resident NN cord-302953-gr2kk9w4 407 14 memory memory NN cord-302953-gr2kk9w4 407 15 CD8 CD8 NNP cord-302953-gr2kk9w4 407 16 + + CC cord-302953-gr2kk9w4 407 17 T T NNP cord-302953-gr2kk9w4 407 18 cells cell NNS cord-302953-gr2kk9w4 407 19 during during IN cord-302953-gr2kk9w4 407 20 influenza influenza JJ cord-302953-gr2kk9w4 407 21 viral viral JJ cord-302953-gr2kk9w4 407 22 infection infection NN cord-302953-gr2kk9w4 407 23 This this DT cord-302953-gr2kk9w4 407 24 article article NN cord-302953-gr2kk9w4 407 25 is be VBZ cord-302953-gr2kk9w4 407 26 an an DT cord-302953-gr2kk9w4 407 27 open open JJ cord-302953-gr2kk9w4 407 28 access access NN cord-302953-gr2kk9w4 407 29 article article NN cord-302953-gr2kk9w4 407 30 distributed distribute VBN cord-302953-gr2kk9w4 407 31 under under IN cord-302953-gr2kk9w4 407 32 the the DT cord-302953-gr2kk9w4 407 33 terms term NNS cord-302953-gr2kk9w4 407 34 and and CC cord-302953-gr2kk9w4 407 35 conditions condition NNS cord-302953-gr2kk9w4 407 36 of of IN cord-302953-gr2kk9w4 407 37 the the DT cord-302953-gr2kk9w4 407 38 Creative Creative NNP cord-302953-gr2kk9w4 407 39 Commons Commons NNP cord-302953-gr2kk9w4 407 40 Attribution Attribution NNP cord-302953-gr2kk9w4 407 41 ( ( -LRB- cord-302953-gr2kk9w4 407 42 CC CC NNP cord-302953-gr2kk9w4 407 43 BY by IN cord-302953-gr2kk9w4 407 44 ) ) -RRB- cord-302953-gr2kk9w4 407 45 license license NN cord-302953-gr2kk9w4 407 46 We -PRON- PRP cord-302953-gr2kk9w4 407 47 thank thank VBP cord-302953-gr2kk9w4 407 48 Kimberly Kimberly NNP cord-302953-gr2kk9w4 407 49 Schultz Schultz NNP cord-302953-gr2kk9w4 407 50 , , , cord-302953-gr2kk9w4 407 51 Kirsten Kirsten NNP cord-302953-gr2kk9w4 407 52 Kulcsar Kulcsar NNP cord-302953-gr2kk9w4 407 53 , , , cord-302953-gr2kk9w4 407 54 Lisa Lisa NNP cord-302953-gr2kk9w4 407 55 Mangus Mangus NNP cord-302953-gr2kk9w4 407 56 , , , cord-302953-gr2kk9w4 407 57 and and CC cord-302953-gr2kk9w4 407 58 Lauren Lauren NNP cord-302953-gr2kk9w4 407 59 Peiffer Peiffer NNP cord-302953-gr2kk9w4 407 60 for for IN cord-302953-gr2kk9w4 407 61 helpful helpful JJ cord-302953-gr2kk9w4 407 62 discussions discussion NNS cord-302953-gr2kk9w4 407 63 and and CC cord-302953-gr2kk9w4 407 64 Elizabeth Elizabeth NNP cord-302953-gr2kk9w4 407 65 Troisi Troisi NNP cord-302953-gr2kk9w4 407 66 and and CC cord-302953-gr2kk9w4 407 67 Jane Jane NNP cord-302953-gr2kk9w4 407 68 Yeh Yeh NNP cord-302953-gr2kk9w4 407 69 for for IN cord-302953-gr2kk9w4 407 70 technical technical JJ cord-302953-gr2kk9w4 407 71 assistance assistance NN cord-302953-gr2kk9w4 407 72 . . . cord-302953-gr2kk9w4 408 1 The the DT cord-302953-gr2kk9w4 408 2 funders funder NNS cord-302953-gr2kk9w4 408 3 had have VBD cord-302953-gr2kk9w4 408 4 no no DT cord-302953-gr2kk9w4 408 5 role role NN cord-302953-gr2kk9w4 408 6 in in IN cord-302953-gr2kk9w4 408 7 the the DT cord-302953-gr2kk9w4 408 8 design design NN cord-302953-gr2kk9w4 408 9 of of IN cord-302953-gr2kk9w4 408 10 the the DT cord-302953-gr2kk9w4 408 11 study study NN cord-302953-gr2kk9w4 408 12 , , , cord-302953-gr2kk9w4 408 13 in in IN cord-302953-gr2kk9w4 408 14 the the DT cord-302953-gr2kk9w4 408 15 collection collection NN cord-302953-gr2kk9w4 408 16 , , , cord-302953-gr2kk9w4 408 17 analyses analysis NNS cord-302953-gr2kk9w4 408 18 , , , cord-302953-gr2kk9w4 408 19 or or CC cord-302953-gr2kk9w4 408 20 interpretation interpretation NN cord-302953-gr2kk9w4 408 21 of of IN cord-302953-gr2kk9w4 408 22 data datum NNS cord-302953-gr2kk9w4 408 23 , , , cord-302953-gr2kk9w4 408 24 in in IN cord-302953-gr2kk9w4 408 25 the the DT cord-302953-gr2kk9w4 408 26 writing writing NN cord-302953-gr2kk9w4 408 27 of of IN cord-302953-gr2kk9w4 408 28 the the DT cord-302953-gr2kk9w4 408 29 manuscript manuscript NN cord-302953-gr2kk9w4 408 30 , , , cord-302953-gr2kk9w4 408 31 or or CC cord-302953-gr2kk9w4 408 32 in in IN cord-302953-gr2kk9w4 408 33 the the DT cord-302953-gr2kk9w4 408 34 decision decision NN cord-302953-gr2kk9w4 408 35 to to TO cord-302953-gr2kk9w4 408 36 publish publish VB cord-302953-gr2kk9w4 408 37 the the DT cord-302953-gr2kk9w4 408 38 results result NNS cord-302953-gr2kk9w4 408 39 . . . cord-302953-gr2kk9w4 409 1 The the DT cord-302953-gr2kk9w4 409 2 authors author NNS cord-302953-gr2kk9w4 409 3 declare declare VBP cord-302953-gr2kk9w4 409 4 no no DT cord-302953-gr2kk9w4 409 5 conflicts conflict NNS cord-302953-gr2kk9w4 409 6 of of IN cord-302953-gr2kk9w4 409 7 interest interest NN cord-302953-gr2kk9w4 409 8 . . .