id sid tid token lemma pos cord-261417-4pf5nsw2 1 1 key key JJ cord-261417-4pf5nsw2 1 2 : : : cord-261417-4pf5nsw2 1 3 cord-261417 cord-261417 ADD cord-261417-4pf5nsw2 1 4 - - HYPH cord-261417-4pf5nsw2 1 5 4pf5nsw2 4pf5nsw2 CD cord-261417-4pf5nsw2 1 6 authors author NNS cord-261417-4pf5nsw2 1 7 : : : cord-261417-4pf5nsw2 1 8 Harwig Harwig NNP cord-261417-4pf5nsw2 1 9 , , , cord-261417-4pf5nsw2 1 10 Alex Alex NNP cord-261417-4pf5nsw2 1 11 ; ; : cord-261417-4pf5nsw2 1 12 Landick Landick NNP cord-261417-4pf5nsw2 1 13 , , , cord-261417-4pf5nsw2 1 14 Robert Robert NNP cord-261417-4pf5nsw2 1 15 ; ; : cord-261417-4pf5nsw2 1 16 Berkhout Berkhout NNP cord-261417-4pf5nsw2 1 17 , , , cord-261417-4pf5nsw2 2 1 Ben Ben NNP cord-261417-4pf5nsw2 2 2 title title NN cord-261417-4pf5nsw2 2 3 : : : cord-261417-4pf5nsw2 3 1 The the DT cord-261417-4pf5nsw2 3 2 Battle Battle NNP cord-261417-4pf5nsw2 3 3 of of IN cord-261417-4pf5nsw2 3 4 RNA RNA NNP cord-261417-4pf5nsw2 3 5 Synthesis Synthesis NNP cord-261417-4pf5nsw2 3 6 : : : cord-261417-4pf5nsw2 3 7 Virus virus NN cord-261417-4pf5nsw2 3 8 versus versus IN cord-261417-4pf5nsw2 3 9 Host Host NNP cord-261417-4pf5nsw2 3 10 date date NN cord-261417-4pf5nsw2 3 11 : : : cord-261417-4pf5nsw2 3 12 2017 2017 CD cord-261417-4pf5nsw2 3 13 - - SYM cord-261417-4pf5nsw2 3 14 10 10 CD cord-261417-4pf5nsw2 3 15 - - SYM cord-261417-4pf5nsw2 3 16 21 21 CD cord-261417-4pf5nsw2 3 17 journal journal NN cord-261417-4pf5nsw2 3 18 : : : cord-261417-4pf5nsw2 3 19 Viruses virus NNS cord-261417-4pf5nsw2 3 20 DOI DOI NNP cord-261417-4pf5nsw2 3 21 : : : cord-261417-4pf5nsw2 4 1 10.3390 10.3390 CD cord-261417-4pf5nsw2 4 2 / / SYM cord-261417-4pf5nsw2 4 3 v9100309 v9100309 NNP cord-261417-4pf5nsw2 4 4 sha sha NNP cord-261417-4pf5nsw2 4 5 : : : cord-261417-4pf5nsw2 5 1 bbffb6a287ece187b7ad9ceb9f703854b0ea8e1d bbffb6a287ece187b7ad9ceb9f703854b0ea8e1d NNP cord-261417-4pf5nsw2 5 2 doc_id doc_id CD cord-261417-4pf5nsw2 5 3 : : : cord-261417-4pf5nsw2 5 4 261417 261417 CD cord-261417-4pf5nsw2 5 5 cord_uid cord_uid NNS cord-261417-4pf5nsw2 5 6 : : : cord-261417-4pf5nsw2 6 1 4pf5nsw2 4pf5nsw2 CD cord-261417-4pf5nsw2 6 2 Transcription Transcription NNP cord-261417-4pf5nsw2 6 3 control control NN cord-261417-4pf5nsw2 6 4 is be VBZ cord-261417-4pf5nsw2 6 5 the the DT cord-261417-4pf5nsw2 6 6 foundation foundation NN cord-261417-4pf5nsw2 6 7 of of IN cord-261417-4pf5nsw2 6 8 gene gene NN cord-261417-4pf5nsw2 6 9 regulation regulation NN cord-261417-4pf5nsw2 6 10 . . . cord-261417-4pf5nsw2 7 1 Whereas whereas IN cord-261417-4pf5nsw2 7 2 a a DT cord-261417-4pf5nsw2 7 3 cell cell NN cord-261417-4pf5nsw2 7 4 is be VBZ cord-261417-4pf5nsw2 7 5 fully fully RB cord-261417-4pf5nsw2 7 6 equipped equip VBN cord-261417-4pf5nsw2 7 7 for for IN cord-261417-4pf5nsw2 7 8 this this DT cord-261417-4pf5nsw2 7 9 task task NN cord-261417-4pf5nsw2 7 10 , , , cord-261417-4pf5nsw2 7 11 viruses virus NNS cord-261417-4pf5nsw2 7 12 often often RB cord-261417-4pf5nsw2 7 13 depend depend VBP cord-261417-4pf5nsw2 7 14 on on IN cord-261417-4pf5nsw2 7 15 the the DT cord-261417-4pf5nsw2 7 16 host host NN cord-261417-4pf5nsw2 7 17 to to TO cord-261417-4pf5nsw2 7 18 supply supply VB cord-261417-4pf5nsw2 7 19 tools tool NNS cord-261417-4pf5nsw2 7 20 for for IN cord-261417-4pf5nsw2 7 21 their -PRON- PRP$ cord-261417-4pf5nsw2 7 22 transcription transcription NN cord-261417-4pf5nsw2 7 23 program program NN cord-261417-4pf5nsw2 7 24 . . . cord-261417-4pf5nsw2 8 1 Over over IN cord-261417-4pf5nsw2 8 2 the the DT cord-261417-4pf5nsw2 8 3 course course NN cord-261417-4pf5nsw2 8 4 of of IN cord-261417-4pf5nsw2 8 5 evolution evolution NN cord-261417-4pf5nsw2 8 6 and and CC cord-261417-4pf5nsw2 8 7 adaptation adaptation NN cord-261417-4pf5nsw2 8 8 , , , cord-261417-4pf5nsw2 8 9 viruses virus NNS cord-261417-4pf5nsw2 8 10 have have VBP cord-261417-4pf5nsw2 8 11 found find VBN cord-261417-4pf5nsw2 8 12 diverse diverse JJ cord-261417-4pf5nsw2 8 13 ways way NNS cord-261417-4pf5nsw2 8 14 to to TO cord-261417-4pf5nsw2 8 15 optimally optimally RB cord-261417-4pf5nsw2 8 16 exploit exploit VB cord-261417-4pf5nsw2 8 17 cellular cellular JJ cord-261417-4pf5nsw2 8 18 host host NN cord-261417-4pf5nsw2 8 19 processes process NNS cord-261417-4pf5nsw2 8 20 such such JJ cord-261417-4pf5nsw2 8 21 as as IN cord-261417-4pf5nsw2 8 22 transcription transcription NN cord-261417-4pf5nsw2 8 23 to to IN cord-261417-4pf5nsw2 8 24 their -PRON- PRP$ cord-261417-4pf5nsw2 8 25 own own JJ cord-261417-4pf5nsw2 8 26 benefit benefit NN cord-261417-4pf5nsw2 8 27 . . . cord-261417-4pf5nsw2 9 1 Just just RB cord-261417-4pf5nsw2 9 2 as as IN cord-261417-4pf5nsw2 9 3 cells cell NNS cord-261417-4pf5nsw2 9 4 are be VBP cord-261417-4pf5nsw2 9 5 increasingly increasingly RB cord-261417-4pf5nsw2 9 6 understood understand VBN cord-261417-4pf5nsw2 9 7 to to TO cord-261417-4pf5nsw2 9 8 employ employ VB cord-261417-4pf5nsw2 9 9 nascent nascent JJ cord-261417-4pf5nsw2 9 10 RNAs rna NNS cord-261417-4pf5nsw2 9 11 in in IN cord-261417-4pf5nsw2 9 12 transcription transcription NN cord-261417-4pf5nsw2 9 13 regulation regulation NN cord-261417-4pf5nsw2 9 14 , , , cord-261417-4pf5nsw2 9 15 recent recent JJ cord-261417-4pf5nsw2 9 16 discoveries discovery NNS cord-261417-4pf5nsw2 9 17 are be VBP cord-261417-4pf5nsw2 9 18 revealing reveal VBG cord-261417-4pf5nsw2 9 19 how how WRB cord-261417-4pf5nsw2 9 20 viruses virus NNS cord-261417-4pf5nsw2 9 21 use use VBP cord-261417-4pf5nsw2 9 22 nascent nascent JJ cord-261417-4pf5nsw2 9 23 RNAs rna NNS cord-261417-4pf5nsw2 9 24 to to TO cord-261417-4pf5nsw2 9 25 benefit benefit VB cord-261417-4pf5nsw2 9 26 their -PRON- PRP$ cord-261417-4pf5nsw2 9 27 own own JJ cord-261417-4pf5nsw2 9 28 gene gene NN cord-261417-4pf5nsw2 9 29 expression expression NN cord-261417-4pf5nsw2 9 30 . . . cord-261417-4pf5nsw2 10 1 In in IN cord-261417-4pf5nsw2 10 2 this this DT cord-261417-4pf5nsw2 10 3 review review NN cord-261417-4pf5nsw2 10 4 , , , cord-261417-4pf5nsw2 10 5 we -PRON- PRP cord-261417-4pf5nsw2 10 6 first first RB cord-261417-4pf5nsw2 10 7 outline outline VBP cord-261417-4pf5nsw2 10 8 the the DT cord-261417-4pf5nsw2 10 9 two two CD cord-261417-4pf5nsw2 10 10 different different JJ cord-261417-4pf5nsw2 10 11 transcription transcription NN cord-261417-4pf5nsw2 10 12 programs program NNS cord-261417-4pf5nsw2 10 13 used use VBN cord-261417-4pf5nsw2 10 14 by by IN cord-261417-4pf5nsw2 10 15 viruses virus NNS cord-261417-4pf5nsw2 10 16 , , , cord-261417-4pf5nsw2 10 17 i.e. i.e. FW cord-261417-4pf5nsw2 10 18 , , , cord-261417-4pf5nsw2 10 19 transcription transcription NN cord-261417-4pf5nsw2 10 20 ( ( -LRB- cord-261417-4pf5nsw2 10 21 DNA dna NN cord-261417-4pf5nsw2 10 22 - - HYPH cord-261417-4pf5nsw2 10 23 dependent dependent JJ cord-261417-4pf5nsw2 10 24 ) ) -RRB- cord-261417-4pf5nsw2 10 25 and and CC cord-261417-4pf5nsw2 10 26 RNA RNA NNP cord-261417-4pf5nsw2 10 27 - - HYPH cord-261417-4pf5nsw2 10 28 dependent dependent JJ cord-261417-4pf5nsw2 10 29 RNA RNA NNP cord-261417-4pf5nsw2 10 30 synthesis synthesis NN cord-261417-4pf5nsw2 10 31 . . . cord-261417-4pf5nsw2 11 1 Subsequently subsequently RB cord-261417-4pf5nsw2 11 2 , , , cord-261417-4pf5nsw2 11 3 we -PRON- PRP cord-261417-4pf5nsw2 11 4 use use VBP cord-261417-4pf5nsw2 11 5 the the DT cord-261417-4pf5nsw2 11 6 distinct distinct JJ cord-261417-4pf5nsw2 11 7 stages stage NNS cord-261417-4pf5nsw2 11 8 ( ( -LRB- cord-261417-4pf5nsw2 11 9 initiation initiation NN cord-261417-4pf5nsw2 11 10 , , , cord-261417-4pf5nsw2 11 11 elongation elongation NN cord-261417-4pf5nsw2 11 12 , , , cord-261417-4pf5nsw2 11 13 termination termination NN cord-261417-4pf5nsw2 11 14 ) ) -RRB- cord-261417-4pf5nsw2 11 15 to to TO cord-261417-4pf5nsw2 11 16 describe describe VB cord-261417-4pf5nsw2 11 17 the the DT cord-261417-4pf5nsw2 11 18 latest late JJS cord-261417-4pf5nsw2 11 19 insights insight NNS cord-261417-4pf5nsw2 11 20 into into IN cord-261417-4pf5nsw2 11 21 nascent nascent JJ cord-261417-4pf5nsw2 11 22 RNA rna NN cord-261417-4pf5nsw2 11 23 - - HYPH cord-261417-4pf5nsw2 11 24 mediated mediate VBN cord-261417-4pf5nsw2 11 25 regulation regulation NN cord-261417-4pf5nsw2 11 26 in in IN cord-261417-4pf5nsw2 11 27 the the DT cord-261417-4pf5nsw2 11 28 context context NN cord-261417-4pf5nsw2 11 29 of of IN cord-261417-4pf5nsw2 11 30 each each DT cord-261417-4pf5nsw2 11 31 relevant relevant JJ cord-261417-4pf5nsw2 11 32 stage stage NN cord-261417-4pf5nsw2 11 33 . . . cord-261417-4pf5nsw2 12 1 All all DT cord-261417-4pf5nsw2 12 2 living live VBG cord-261417-4pf5nsw2 12 3 organisms organism NNS cord-261417-4pf5nsw2 12 4 are be VBP cord-261417-4pf5nsw2 12 5 fully fully RB cord-261417-4pf5nsw2 12 6 equipped equipped JJ cord-261417-4pf5nsw2 12 7 to to TO cord-261417-4pf5nsw2 12 8 synthesize synthesize VB cord-261417-4pf5nsw2 12 9 messenger messenger NN cord-261417-4pf5nsw2 12 10 RNA RNA NNP cord-261417-4pf5nsw2 12 11 ( ( -LRB- cord-261417-4pf5nsw2 12 12 mRNA mrna NN cord-261417-4pf5nsw2 12 13 ) ) -RRB- cord-261417-4pf5nsw2 12 14 using use VBG cord-261417-4pf5nsw2 12 15 their -PRON- PRP$ cord-261417-4pf5nsw2 12 16 endogenously endogenously RB cord-261417-4pf5nsw2 12 17 encoded encode VBN cord-261417-4pf5nsw2 12 18 multi multi JJ cord-261417-4pf5nsw2 12 19 - - JJ cord-261417-4pf5nsw2 12 20 subunit subunit JJ cord-261417-4pf5nsw2 12 21 RNA RNA NNP cord-261417-4pf5nsw2 12 22 polymerases polymerase NNS cord-261417-4pf5nsw2 12 23 ( ( -LRB- cord-261417-4pf5nsw2 12 24 RNAPs rnaps ADD cord-261417-4pf5nsw2 12 25 ) ) -RRB- cord-261417-4pf5nsw2 12 26 . . . cord-261417-4pf5nsw2 13 1 However however RB cord-261417-4pf5nsw2 13 2 , , , cord-261417-4pf5nsw2 13 3 many many JJ cord-261417-4pf5nsw2 13 4 viruses virus NNS cord-261417-4pf5nsw2 13 5 form form VBP cord-261417-4pf5nsw2 13 6 an an DT cord-261417-4pf5nsw2 13 7 exception exception NN cord-261417-4pf5nsw2 13 8 to to IN cord-261417-4pf5nsw2 13 9 this this DT cord-261417-4pf5nsw2 13 10 dogma dogma NN cord-261417-4pf5nsw2 13 11 and and CC cord-261417-4pf5nsw2 13 12 employ employ VB cord-261417-4pf5nsw2 13 13 a a DT cord-261417-4pf5nsw2 13 14 parasitic parasitic JJ cord-261417-4pf5nsw2 13 15 lifestyle lifestyle NN cord-261417-4pf5nsw2 13 16 that that WDT cord-261417-4pf5nsw2 13 17 exploit exploit VBP cord-261417-4pf5nsw2 13 18 parts part NNS cord-261417-4pf5nsw2 13 19 of of IN cord-261417-4pf5nsw2 13 20 the the DT cord-261417-4pf5nsw2 13 21 host host NN cord-261417-4pf5nsw2 13 22 transcription transcription NN cord-261417-4pf5nsw2 13 23 pathways pathway NNS cord-261417-4pf5nsw2 13 24 . . . cord-261417-4pf5nsw2 14 1 This this DT cord-261417-4pf5nsw2 14 2 co co NN cord-261417-4pf5nsw2 14 3 - - NN cord-261417-4pf5nsw2 14 4 option option NN cord-261417-4pf5nsw2 14 5 allows allow VBZ cord-261417-4pf5nsw2 14 6 viruses virus NNS cord-261417-4pf5nsw2 14 7 to to TO cord-261417-4pf5nsw2 14 8 dramatically dramatically RB cord-261417-4pf5nsw2 14 9 downsize downsize VB cord-261417-4pf5nsw2 14 10 their -PRON- PRP$ cord-261417-4pf5nsw2 14 11 genomes genome NNS cord-261417-4pf5nsw2 14 12 to to IN cord-261417-4pf5nsw2 14 13 the the DT cord-261417-4pf5nsw2 14 14 minimum minimum JJ cord-261417-4pf5nsw2 14 15 number number NN cord-261417-4pf5nsw2 14 16 of of IN cord-261417-4pf5nsw2 14 17 genes gene NNS cord-261417-4pf5nsw2 14 18 essential essential JJ cord-261417-4pf5nsw2 14 19 for for IN cord-261417-4pf5nsw2 14 20 successful successful JJ cord-261417-4pf5nsw2 14 21 infection infection NN cord-261417-4pf5nsw2 14 22 . . . cord-261417-4pf5nsw2 15 1 As as IN cord-261417-4pf5nsw2 15 2 a a DT cord-261417-4pf5nsw2 15 3 result result NN cord-261417-4pf5nsw2 15 4 , , , cord-261417-4pf5nsw2 15 5 viruses virus NNS cord-261417-4pf5nsw2 15 6 and and CC cord-261417-4pf5nsw2 15 7 their -PRON- PRP$ cord-261417-4pf5nsw2 15 8 hosts host NNS cord-261417-4pf5nsw2 15 9 have have VBP cord-261417-4pf5nsw2 15 10 been be VBN cord-261417-4pf5nsw2 15 11 involved involve VBN cord-261417-4pf5nsw2 15 12 in in IN cord-261417-4pf5nsw2 15 13 an an DT cord-261417-4pf5nsw2 15 14 eternal eternal JJ cord-261417-4pf5nsw2 15 15 battle battle NN cord-261417-4pf5nsw2 15 16 of of IN cord-261417-4pf5nsw2 15 17 adaptation adaptation NN cord-261417-4pf5nsw2 15 18 and and CC cord-261417-4pf5nsw2 15 19 counter counter NN cord-261417-4pf5nsw2 15 20 - - NN cord-261417-4pf5nsw2 15 21 adaptation adaptation NN cord-261417-4pf5nsw2 15 22 for for IN cord-261417-4pf5nsw2 15 23 RNA RNA NNP cord-261417-4pf5nsw2 15 24 synthesis synthesis NN cord-261417-4pf5nsw2 15 25 since since IN cord-261417-4pf5nsw2 15 26 far far RB cord-261417-4pf5nsw2 15 27 before before IN cord-261417-4pf5nsw2 15 28 the the DT cord-261417-4pf5nsw2 15 29 emergence emergence NN cord-261417-4pf5nsw2 15 30 of of IN cord-261417-4pf5nsw2 15 31 humans human NNS cord-261417-4pf5nsw2 15 32 [ [ -LRB- cord-261417-4pf5nsw2 15 33 1 1 CD cord-261417-4pf5nsw2 15 34 ] ] -RRB- cord-261417-4pf5nsw2 15 35 [ [ -LRB- cord-261417-4pf5nsw2 15 36 2 2 CD cord-261417-4pf5nsw2 15 37 ] ] -RRB- cord-261417-4pf5nsw2 15 38 [ [ -LRB- cord-261417-4pf5nsw2 15 39 3 3 CD cord-261417-4pf5nsw2 15 40 ] ] -RRB- cord-261417-4pf5nsw2 15 41 . . . cord-261417-4pf5nsw2 16 1 During during IN cord-261417-4pf5nsw2 16 2 this this DT cord-261417-4pf5nsw2 16 3 time time NN cord-261417-4pf5nsw2 16 4 , , , cord-261417-4pf5nsw2 16 5 viruses virus NNS cord-261417-4pf5nsw2 16 6 coevolved coevolve VBD cord-261417-4pf5nsw2 16 7 many many JJ cord-261417-4pf5nsw2 16 8 pathways pathway NNS cord-261417-4pf5nsw2 16 9 to to TO cord-261417-4pf5nsw2 16 10 transcribe transcribe VB cord-261417-4pf5nsw2 16 11 their -PRON- PRP$ cord-261417-4pf5nsw2 16 12 own own JJ cord-261417-4pf5nsw2 16 13 genetic genetic JJ cord-261417-4pf5nsw2 16 14 material material NN cord-261417-4pf5nsw2 16 15 , , , cord-261417-4pf5nsw2 16 16 meanwhile meanwhile RB cord-261417-4pf5nsw2 16 17 avoiding avoid VBG cord-261417-4pf5nsw2 16 18 counter counter NN cord-261417-4pf5nsw2 16 19 - - NNS cord-261417-4pf5nsw2 16 20 adaptations adaptation NNS cord-261417-4pf5nsw2 16 21 of of IN cord-261417-4pf5nsw2 16 22 the the DT cord-261417-4pf5nsw2 16 23 host host NN cord-261417-4pf5nsw2 16 24 [ [ -LRB- cord-261417-4pf5nsw2 16 25 4 4 CD cord-261417-4pf5nsw2 16 26 ] ] -RRB- cord-261417-4pf5nsw2 16 27 . . . cord-261417-4pf5nsw2 17 1 Weapons weapon NNS cord-261417-4pf5nsw2 17 2 in in IN cord-261417-4pf5nsw2 17 3 the the DT cord-261417-4pf5nsw2 17 4 arsenal arsenal NN cord-261417-4pf5nsw2 17 5 of of IN cord-261417-4pf5nsw2 17 6 the the DT cord-261417-4pf5nsw2 17 7 virus virus NN cord-261417-4pf5nsw2 17 8 include include VBP cord-261417-4pf5nsw2 17 9 virally virally RB cord-261417-4pf5nsw2 17 10 - - HYPH cord-261417-4pf5nsw2 17 11 encoded encode VBN cord-261417-4pf5nsw2 17 12 proteins protein NNS cord-261417-4pf5nsw2 17 13 and and CC cord-261417-4pf5nsw2 17 14 micro micro NNP cord-261417-4pf5nsw2 17 15 RNAs RNAs NNPS cord-261417-4pf5nsw2 17 16 ( ( -LRB- cord-261417-4pf5nsw2 17 17 miRNAs miRNAs NNP cord-261417-4pf5nsw2 17 18 ) ) -RRB- cord-261417-4pf5nsw2 17 19 , , , cord-261417-4pf5nsw2 17 20 which which WDT cord-261417-4pf5nsw2 17 21 alter alter VBP cord-261417-4pf5nsw2 17 22 transcription transcription NN cord-261417-4pf5nsw2 17 23 pathways pathway NNS cord-261417-4pf5nsw2 17 24 in in IN cord-261417-4pf5nsw2 17 25 both both DT cord-261417-4pf5nsw2 17 26 host host NN cord-261417-4pf5nsw2 17 27 and and CC cord-261417-4pf5nsw2 17 28 virus virus NN cord-261417-4pf5nsw2 17 29 via via IN cord-261417-4pf5nsw2 17 30 many many JJ cord-261417-4pf5nsw2 17 31 different different JJ cord-261417-4pf5nsw2 17 32 mechanisms mechanism NNS cord-261417-4pf5nsw2 17 33 . . . cord-261417-4pf5nsw2 18 1 These these DT cord-261417-4pf5nsw2 18 2 mechanisms mechanism NNS cord-261417-4pf5nsw2 18 3 have have VBP cord-261417-4pf5nsw2 18 4 been be VBN cord-261417-4pf5nsw2 18 5 reviewed review VBN cord-261417-4pf5nsw2 18 6 extensively extensively RB cord-261417-4pf5nsw2 18 7 elsewhere elsewhere RB cord-261417-4pf5nsw2 18 8 ( ( -LRB- cord-261417-4pf5nsw2 18 9 for for IN cord-261417-4pf5nsw2 18 10 example example NN cord-261417-4pf5nsw2 18 11 [ [ -LRB- cord-261417-4pf5nsw2 18 12 5 5 LS cord-261417-4pf5nsw2 18 13 ] ] -RRB- cord-261417-4pf5nsw2 18 14 [ [ -LRB- cord-261417-4pf5nsw2 18 15 6 6 CD cord-261417-4pf5nsw2 18 16 ] ] -RRB- cord-261417-4pf5nsw2 18 17 [ [ -LRB- cord-261417-4pf5nsw2 18 18 7 7 CD cord-261417-4pf5nsw2 18 19 ] ] -RRB- cord-261417-4pf5nsw2 18 20 [ [ -LRB- cord-261417-4pf5nsw2 18 21 8 8 CD cord-261417-4pf5nsw2 18 22 ] ] -RRB- cord-261417-4pf5nsw2 18 23 ) ) -RRB- cord-261417-4pf5nsw2 18 24 . . . cord-261417-4pf5nsw2 19 1 However however RB cord-261417-4pf5nsw2 19 2 , , , cord-261417-4pf5nsw2 19 3 one one CD cord-261417-4pf5nsw2 19 4 major major NN cord-261417-4pf5nsw2 19 5 , , , cord-261417-4pf5nsw2 19 6 yet yet CC cord-261417-4pf5nsw2 19 7 underappreciated underappreciated JJ cord-261417-4pf5nsw2 19 8 , , , cord-261417-4pf5nsw2 19 9 component component NN cord-261417-4pf5nsw2 19 10 of of IN cord-261417-4pf5nsw2 19 11 viral viral JJ cord-261417-4pf5nsw2 19 12 gene gene NN cord-261417-4pf5nsw2 19 13 regulation regulation NN cord-261417-4pf5nsw2 19 14 occurs occur VBZ cord-261417-4pf5nsw2 19 15 via via IN cord-261417-4pf5nsw2 19 16 nascent nascent JJ cord-261417-4pf5nsw2 19 17 RNAs rna NNS cord-261417-4pf5nsw2 19 18 . . . cord-261417-4pf5nsw2 20 1 RNAs rna NNS cord-261417-4pf5nsw2 20 2 have have VBP cord-261417-4pf5nsw2 20 3 many many JJ cord-261417-4pf5nsw2 20 4 attractive attractive JJ cord-261417-4pf5nsw2 20 5 properties property NNS cord-261417-4pf5nsw2 20 6 that that WDT cord-261417-4pf5nsw2 20 7 can can MD cord-261417-4pf5nsw2 20 8 be be VB cord-261417-4pf5nsw2 20 9 used use VBN cord-261417-4pf5nsw2 20 10 by by IN cord-261417-4pf5nsw2 20 11 viruses virus NNS cord-261417-4pf5nsw2 20 12 to to TO cord-261417-4pf5nsw2 20 13 manipulate manipulate VB cord-261417-4pf5nsw2 20 14 gene gene NN cord-261417-4pf5nsw2 20 15 regulation regulation NN cord-261417-4pf5nsw2 20 16 pathways pathway NNS cord-261417-4pf5nsw2 20 17 . . . cord-261417-4pf5nsw2 21 1 First first RB cord-261417-4pf5nsw2 21 2 , , , cord-261417-4pf5nsw2 21 3 RNAs rna NNS cord-261417-4pf5nsw2 21 4 , , , cord-261417-4pf5nsw2 21 5 like like IN cord-261417-4pf5nsw2 21 6 DNAs dna NNS cord-261417-4pf5nsw2 21 7 , , , cord-261417-4pf5nsw2 21 8 can can MD cord-261417-4pf5nsw2 21 9 specifically specifically RB cord-261417-4pf5nsw2 21 10 pair pair VB cord-261417-4pf5nsw2 21 11 with with IN cord-261417-4pf5nsw2 21 12 complementary complementary JJ cord-261417-4pf5nsw2 21 13 viral viral NN cord-261417-4pf5nsw2 21 14 or or CC cord-261417-4pf5nsw2 21 15 host host NN cord-261417-4pf5nsw2 21 16 sequences sequence NNS cord-261417-4pf5nsw2 21 17 using use VBG cord-261417-4pf5nsw2 21 18 minimal minimal JJ cord-261417-4pf5nsw2 21 19 investment investment NN cord-261417-4pf5nsw2 21 20 of of IN cord-261417-4pf5nsw2 21 21 genetic genetic JJ cord-261417-4pf5nsw2 21 22 material material NN cord-261417-4pf5nsw2 21 23 , , , cord-261417-4pf5nsw2 21 24 thus thus RB cord-261417-4pf5nsw2 21 25 allowing allow VBG cord-261417-4pf5nsw2 21 26 further further JJ cord-261417-4pf5nsw2 21 27 minimization minimization NN cord-261417-4pf5nsw2 21 28 of of IN cord-261417-4pf5nsw2 21 29 the the DT cord-261417-4pf5nsw2 21 30 viral viral JJ cord-261417-4pf5nsw2 21 31 genome genome NN cord-261417-4pf5nsw2 21 32 . . . cord-261417-4pf5nsw2 22 1 Encoding encode VBG cord-261417-4pf5nsw2 22 2 a a DT cord-261417-4pf5nsw2 22 3 DNA dna NN cord-261417-4pf5nsw2 22 4 - - HYPH cord-261417-4pf5nsw2 22 5 binding bind VBG cord-261417-4pf5nsw2 22 6 protein protein NN cord-261417-4pf5nsw2 22 7 , , , cord-261417-4pf5nsw2 22 8 on on IN cord-261417-4pf5nsw2 22 9 the the DT cord-261417-4pf5nsw2 22 10 other other JJ cord-261417-4pf5nsw2 22 11 hand hand NN cord-261417-4pf5nsw2 22 12 , , , cord-261417-4pf5nsw2 22 13 consumes consume VBZ cord-261417-4pf5nsw2 22 14 significantly significantly RB cord-261417-4pf5nsw2 22 15 more more RBR cord-261417-4pf5nsw2 22 16 genetic genetic JJ cord-261417-4pf5nsw2 22 17 information information NN cord-261417-4pf5nsw2 22 18 . . . cord-261417-4pf5nsw2 23 1 A a DT cord-261417-4pf5nsw2 23 2 typical typical JJ cord-261417-4pf5nsw2 23 3 DNA dna NN cord-261417-4pf5nsw2 23 4 - - HYPH cord-261417-4pf5nsw2 23 5 binding bind VBG cord-261417-4pf5nsw2 23 6 domain domain NN cord-261417-4pf5nsw2 23 7 recognizes~10 recognizes~10 NNP cord-261417-4pf5nsw2 23 8 base base NN cord-261417-4pf5nsw2 23 9 pairs pair NNS cord-261417-4pf5nsw2 23 10 ( ( -LRB- cord-261417-4pf5nsw2 23 11 bp bp NNP cord-261417-4pf5nsw2 23 12 ) ) -RRB- cord-261417-4pf5nsw2 23 13 or or CC cord-261417-4pf5nsw2 23 14 more more JJR cord-261417-4pf5nsw2 23 15 of of IN cord-261417-4pf5nsw2 23 16 DNA dna NN cord-261417-4pf5nsw2 23 17 and and CC cord-261417-4pf5nsw2 23 18 comprises comprise VBZ cord-261417-4pf5nsw2 23 19 at at RB cord-261417-4pf5nsw2 23 20 least least RBS cord-261417-4pf5nsw2 23 21 60 60 CD cord-261417-4pf5nsw2 23 22 amino amino NN cord-261417-4pf5nsw2 23 23 acids acid NNS cord-261417-4pf5nsw2 23 24 ( ( -LRB- cord-261417-4pf5nsw2 23 25 aa aa NNP cord-261417-4pf5nsw2 23 26 ) ) -RRB- cord-261417-4pf5nsw2 23 27 , , , cord-261417-4pf5nsw2 23 28 thereby thereby RB cord-261417-4pf5nsw2 23 29 requiring require VBG cord-261417-4pf5nsw2 23 30 180 180 CD cord-261417-4pf5nsw2 23 31 bp bp NNS cord-261417-4pf5nsw2 23 32 of of IN cord-261417-4pf5nsw2 23 33 encoding encode VBG cord-261417-4pf5nsw2 23 34 DNA DNA NNP cord-261417-4pf5nsw2 23 35 [ [ -LRB- cord-261417-4pf5nsw2 23 36 9 9 CD cord-261417-4pf5nsw2 23 37 ] ] -RRB- cord-261417-4pf5nsw2 23 38 . . . cord-261417-4pf5nsw2 24 1 In in IN cord-261417-4pf5nsw2 24 2 contrast contrast NN cord-261417-4pf5nsw2 24 3 , , , cord-261417-4pf5nsw2 24 4 RNA RNA NNP cord-261417-4pf5nsw2 24 5 requires require VBZ cord-261417-4pf5nsw2 24 6 only only RB cord-261417-4pf5nsw2 24 7 the the DT cord-261417-4pf5nsw2 24 8 number number NN cord-261417-4pf5nsw2 24 9 of of IN cord-261417-4pf5nsw2 24 10 complementary complementary JJ cord-261417-4pf5nsw2 24 11 nucleotides nucleotide NNS cord-261417-4pf5nsw2 24 12 as as IN cord-261417-4pf5nsw2 24 13 the the DT cord-261417-4pf5nsw2 24 14 DNA DNA NNP cord-261417-4pf5nsw2 24 15 / / SYM cord-261417-4pf5nsw2 24 16 RNA RNA NNP cord-261417-4pf5nsw2 24 17 region region NN cord-261417-4pf5nsw2 24 18 it -PRON- PRP cord-261417-4pf5nsw2 24 19 recognizes recognize VBZ cord-261417-4pf5nsw2 24 20 . . . cord-261417-4pf5nsw2 25 1 This this DT cord-261417-4pf5nsw2 25 2 can can MD cord-261417-4pf5nsw2 25 3 be be VB cord-261417-4pf5nsw2 25 4 beneficial beneficial JJ cord-261417-4pf5nsw2 25 5 for for IN cord-261417-4pf5nsw2 25 6 the the DT cord-261417-4pf5nsw2 25 7 virus virus NN cord-261417-4pf5nsw2 25 8 where where WRB cord-261417-4pf5nsw2 25 9 space space NN cord-261417-4pf5nsw2 25 10 constraints constraint NNS cord-261417-4pf5nsw2 25 11 are be VBP cord-261417-4pf5nsw2 25 12 dictated dictate VBN cord-261417-4pf5nsw2 25 13 by by IN cord-261417-4pf5nsw2 25 14 the the DT cord-261417-4pf5nsw2 25 15 size size NN cord-261417-4pf5nsw2 25 16 of of IN cord-261417-4pf5nsw2 25 17 the the DT cord-261417-4pf5nsw2 25 18 viral viral JJ cord-261417-4pf5nsw2 25 19 capsid capsid NN cord-261417-4pf5nsw2 25 20 . . . cord-261417-4pf5nsw2 26 1 Second second RB cord-261417-4pf5nsw2 26 2 , , , cord-261417-4pf5nsw2 26 3 RNAs rna NNS cord-261417-4pf5nsw2 26 4 are be VBP cord-261417-4pf5nsw2 26 5 less less RBR cord-261417-4pf5nsw2 26 6 immunogenic immunogenic JJ cord-261417-4pf5nsw2 26 7 compared compare VBN cord-261417-4pf5nsw2 26 8 to to IN cord-261417-4pf5nsw2 26 9 proteins protein NNS cord-261417-4pf5nsw2 26 10 . . . cord-261417-4pf5nsw2 27 1 Whereas whereas IN cord-261417-4pf5nsw2 27 2 hosts host NNS cord-261417-4pf5nsw2 27 3 developed develop VBD cord-261417-4pf5nsw2 27 4 many many JJ cord-261417-4pf5nsw2 27 5 pathways pathway NNS cord-261417-4pf5nsw2 27 6 to to TO cord-261417-4pf5nsw2 27 7 respond respond VB cord-261417-4pf5nsw2 27 8 to to IN cord-261417-4pf5nsw2 27 9 modules module NNS cord-261417-4pf5nsw2 27 10 that that WDT cord-261417-4pf5nsw2 27 11 make make VBP cord-261417-4pf5nsw2 27 12 up up RP cord-261417-4pf5nsw2 27 13 the the DT cord-261417-4pf5nsw2 27 14 RNA RNA NNP cord-261417-4pf5nsw2 27 15 - - HYPH cord-261417-4pf5nsw2 27 16 exit exit NN cord-261417-4pf5nsw2 27 17 channel channel NN cord-261417-4pf5nsw2 27 18 are be VBP cord-261417-4pf5nsw2 27 19 depicted depict VBN cord-261417-4pf5nsw2 27 20 in in IN cord-261417-4pf5nsw2 27 21 pink pink JJ cord-261417-4pf5nsw2 27 22 and and CC cord-261417-4pf5nsw2 27 23 blue blue JJ cord-261417-4pf5nsw2 27 24 , , , cord-261417-4pf5nsw2 27 25 respectively respectively RB cord-261417-4pf5nsw2 27 26 . . . cord-261417-4pf5nsw2 28 1 The the DT cord-261417-4pf5nsw2 28 2 first first JJ cord-261417-4pf5nsw2 28 3 repeat repeat NN cord-261417-4pf5nsw2 28 4 of of IN cord-261417-4pf5nsw2 28 5 the the DT cord-261417-4pf5nsw2 28 6 RNAPII RNAPII NNP cord-261417-4pf5nsw2 28 7 C C NNP cord-261417-4pf5nsw2 28 8 - - HYPH cord-261417-4pf5nsw2 28 9 terminal terminal NN cord-261417-4pf5nsw2 28 10 domain domain NN cord-261417-4pf5nsw2 28 11 ( ( -LRB- cord-261417-4pf5nsw2 28 12 CTD CTD NNP cord-261417-4pf5nsw2 28 13 ) ) -RRB- cord-261417-4pf5nsw2 28 14 is be VBZ cord-261417-4pf5nsw2 28 15 shown show VBN cord-261417-4pf5nsw2 28 16 as as IN cord-261417-4pf5nsw2 28 17 a a DT cord-261417-4pf5nsw2 28 18 string string NN cord-261417-4pf5nsw2 28 19 of of IN cord-261417-4pf5nsw2 28 20 amino amino JJ cord-261417-4pf5nsw2 28 21 acids acid NNS cord-261417-4pf5nsw2 28 22 with with IN cord-261417-4pf5nsw2 28 23 their -PRON- PRP$ cord-261417-4pf5nsw2 28 24 respective respective JJ cord-261417-4pf5nsw2 28 25 numbers number NNS cord-261417-4pf5nsw2 28 26 . . . cord-261417-4pf5nsw2 29 1 Next next RB cord-261417-4pf5nsw2 29 2 , , , cord-261417-4pf5nsw2 29 3 the the DT cord-261417-4pf5nsw2 29 4 stages stage NNS cord-261417-4pf5nsw2 29 5 of of IN cord-261417-4pf5nsw2 29 6 the the DT cord-261417-4pf5nsw2 29 7 transcription transcription NN cord-261417-4pf5nsw2 29 8 cycle cycle NN cord-261417-4pf5nsw2 29 9 are be VBP cord-261417-4pf5nsw2 29 10 shown show VBN cord-261417-4pf5nsw2 29 11 , , , cord-261417-4pf5nsw2 29 12 with with IN cord-261417-4pf5nsw2 29 13 the the DT cord-261417-4pf5nsw2 29 14 viral viral JJ cord-261417-4pf5nsw2 29 15 interfering interfere VBG cord-261417-4pf5nsw2 29 16 mechanisms mechanism NNS cord-261417-4pf5nsw2 29 17 . . . cord-261417-4pf5nsw2 30 1 First first RB cord-261417-4pf5nsw2 30 2 , , , cord-261417-4pf5nsw2 30 3 general general JJ cord-261417-4pf5nsw2 30 4 transcription transcription NN cord-261417-4pf5nsw2 30 5 factors factor NNS cord-261417-4pf5nsw2 30 6 assemble assemble VBP cord-261417-4pf5nsw2 30 7 at at IN cord-261417-4pf5nsw2 30 8 the the DT cord-261417-4pf5nsw2 30 9 promoter promoter NN cord-261417-4pf5nsw2 30 10 and and CC cord-261417-4pf5nsw2 30 11 direct direct JJ cord-261417-4pf5nsw2 30 12 RNAPII RNAPII NNP cord-261417-4pf5nsw2 30 13 towards towards IN cord-261417-4pf5nsw2 30 14 the the DT cord-261417-4pf5nsw2 30 15 transcription transcription NN cord-261417-4pf5nsw2 30 16 start start NN cord-261417-4pf5nsw2 30 17 site site NN cord-261417-4pf5nsw2 30 18 . . . cord-261417-4pf5nsw2 31 1 Transcription transcription NN cord-261417-4pf5nsw2 31 2 factor factor NN cord-261417-4pf5nsw2 31 3 ( ( -LRB- cord-261417-4pf5nsw2 31 4 TF TF NNP cord-261417-4pf5nsw2 31 5 ) ) -RRB- cord-261417-4pf5nsw2 31 6 IIH IIH NNP cord-261417-4pf5nsw2 31 7 phosphorylates phosphorylate VBZ cord-261417-4pf5nsw2 31 8 the the DT cord-261417-4pf5nsw2 31 9 RNAPII RNAPII NNP cord-261417-4pf5nsw2 31 10 at at IN cord-261417-4pf5nsw2 31 11 Ser5 Ser5 NNP cord-261417-4pf5nsw2 31 12 ( ( -LRB- cord-261417-4pf5nsw2 31 13 black black JJ cord-261417-4pf5nsw2 31 14 asterisk asterisk NN cord-261417-4pf5nsw2 31 15 ) ) -RRB- cord-261417-4pf5nsw2 31 16 . . . cord-261417-4pf5nsw2 32 1 TFIIH TFIIH NNP cord-261417-4pf5nsw2 32 2 opens open VBZ cord-261417-4pf5nsw2 32 3 the the DT cord-261417-4pf5nsw2 32 4 DNA dna NN cord-261417-4pf5nsw2 32 5 template template NN cord-261417-4pf5nsw2 32 6 , , , cord-261417-4pf5nsw2 32 7 forming form VBG cord-261417-4pf5nsw2 32 8 the the DT cord-261417-4pf5nsw2 32 9 transcription transcription NN cord-261417-4pf5nsw2 32 10 bubble bubble NN cord-261417-4pf5nsw2 32 11 , , , cord-261417-4pf5nsw2 32 12 permitting permit VBG cord-261417-4pf5nsw2 32 13 RNAPII RNAPII NNP cord-261417-4pf5nsw2 32 14 to to TO cord-261417-4pf5nsw2 32 15 begin begin VB cord-261417-4pf5nsw2 32 16 transcribing transcribe VBG cord-261417-4pf5nsw2 32 17 RNA RNA NNP cord-261417-4pf5nsw2 32 18 in in IN cord-261417-4pf5nsw2 32 19 its -PRON- PRP$ cord-261417-4pf5nsw2 32 20 active active JJ cord-261417-4pf5nsw2 32 21 center center NN cord-261417-4pf5nsw2 32 22 ( ( -LRB- cord-261417-4pf5nsw2 32 23 yellow yellow JJ cord-261417-4pf5nsw2 32 24 dot dot NN cord-261417-4pf5nsw2 32 25 ) ) -RRB- cord-261417-4pf5nsw2 32 26 . . . cord-261417-4pf5nsw2 33 1 Upon upon IN cord-261417-4pf5nsw2 33 2 transcribing transcribe VBG cord-261417-4pf5nsw2 33 3 the the DT cord-261417-4pf5nsw2 33 4 first first JJ cord-261417-4pf5nsw2 33 5 20 20 CD cord-261417-4pf5nsw2 33 6 - - SYM cord-261417-4pf5nsw2 33 7 60 60 CD cord-261417-4pf5nsw2 33 8 nucleotides nucleotide NNS cord-261417-4pf5nsw2 33 9 , , , cord-261417-4pf5nsw2 33 10 most most JJS cord-261417-4pf5nsw2 33 11 RNAP RNAP NNP cord-261417-4pf5nsw2 33 12 will will MD cord-261417-4pf5nsw2 33 13 pause pause VB cord-261417-4pf5nsw2 33 14 . . . cord-261417-4pf5nsw2 34 1 Transcription transcription NN cord-261417-4pf5nsw2 34 2 factor factor NN cord-261417-4pf5nsw2 34 3 recruitment recruitment NN cord-261417-4pf5nsw2 34 4 regulates regulate VBZ cord-261417-4pf5nsw2 34 5 these these DT cord-261417-4pf5nsw2 34 6 transcription transcription NN cord-261417-4pf5nsw2 34 7 kinetics kinetic NNS cord-261417-4pf5nsw2 34 8 and and CC cord-261417-4pf5nsw2 34 9 phosphorylate phosphorylate VB cord-261417-4pf5nsw2 34 10 RNAPII RNAPII NNP cord-261417-4pf5nsw2 34 11 at at IN cord-261417-4pf5nsw2 34 12 Ser2 Ser2 NNP cord-261417-4pf5nsw2 34 13 . . . cord-261417-4pf5nsw2 35 1 When when WRB cord-261417-4pf5nsw2 35 2 the the DT cord-261417-4pf5nsw2 35 3 correct correct JJ cord-261417-4pf5nsw2 35 4 signal signal NN cord-261417-4pf5nsw2 35 5 is be VBZ cord-261417-4pf5nsw2 35 6 encountered encounter VBN cord-261417-4pf5nsw2 35 7 , , , cord-261417-4pf5nsw2 35 8 RNAPII RNAPII NNP cord-261417-4pf5nsw2 35 9 will will MD cord-261417-4pf5nsw2 35 10 terminate terminate VB cord-261417-4pf5nsw2 35 11 transcription transcription NN cord-261417-4pf5nsw2 35 12 and and CC cord-261417-4pf5nsw2 35 13 release release VB cord-261417-4pf5nsw2 35 14 the the DT cord-261417-4pf5nsw2 35 15 RNA RNA NNP cord-261417-4pf5nsw2 35 16 . . . cord-261417-4pf5nsw2 36 1 Some some DT cord-261417-4pf5nsw2 36 2 viruses virus NNS cord-261417-4pf5nsw2 36 3 encode encode VBP cord-261417-4pf5nsw2 36 4 endonucleases endonuclease NNS cord-261417-4pf5nsw2 36 5 ( ( -LRB- cord-261417-4pf5nsw2 36 6 yellow yellow JJ cord-261417-4pf5nsw2 36 7 sphere sphere NN cord-261417-4pf5nsw2 36 8 with with IN cord-261417-4pf5nsw2 36 9 scissor scissor NNP cord-261417-4pf5nsw2 36 10 ) ) -RRB- cord-261417-4pf5nsw2 36 11 that that WDT cord-261417-4pf5nsw2 36 12 can can MD cord-261417-4pf5nsw2 36 13 cleave cleave VB cord-261417-4pf5nsw2 36 14 RNAs rna NNS cord-261417-4pf5nsw2 36 15 , , , cord-261417-4pf5nsw2 36 16 causing cause VBG cord-261417-4pf5nsw2 36 17 RNA RNA NNP cord-261417-4pf5nsw2 36 18 degradation degradation NN cord-261417-4pf5nsw2 36 19 . . . cord-261417-4pf5nsw2 37 1 Initiation initiation NN cord-261417-4pf5nsw2 37 2 is be VBZ cord-261417-4pf5nsw2 37 3 promoted promote VBN cord-261417-4pf5nsw2 37 4 by by IN cord-261417-4pf5nsw2 37 5 factors factor NNS cord-261417-4pf5nsw2 37 6 that that WDT cord-261417-4pf5nsw2 37 7 recruit recruit VBP cord-261417-4pf5nsw2 37 8 RNAP RNAP NNP cord-261417-4pf5nsw2 37 9 to to IN cord-261417-4pf5nsw2 37 10 the the DT cord-261417-4pf5nsw2 37 11 promoter promoter NN cord-261417-4pf5nsw2 37 12 , , , cord-261417-4pf5nsw2 37 13 melt melt VB cord-261417-4pf5nsw2 37 14 the the DT cord-261417-4pf5nsw2 37 15 DNA dna NN cord-261417-4pf5nsw2 37 16 duplex duplex NN cord-261417-4pf5nsw2 37 17 and and CC cord-261417-4pf5nsw2 37 18 load load VB cord-261417-4pf5nsw2 37 19 the the DT cord-261417-4pf5nsw2 37 20 template template NN cord-261417-4pf5nsw2 37 21 DNA dna NN cord-261417-4pf5nsw2 37 22 strand strand NN cord-261417-4pf5nsw2 37 23 into into IN cord-261417-4pf5nsw2 37 24 the the DT cord-261417-4pf5nsw2 37 25 active active JJ cord-261417-4pf5nsw2 37 26 site site NN cord-261417-4pf5nsw2 37 27 of of IN cord-261417-4pf5nsw2 37 28 RNAP RNAP NNP cord-261417-4pf5nsw2 37 29 . . . cord-261417-4pf5nsw2 38 1 For for IN cord-261417-4pf5nsw2 38 2 RNAPII RNAPII NNP cord-261417-4pf5nsw2 38 3 , , , cord-261417-4pf5nsw2 38 4 these these DT cord-261417-4pf5nsw2 38 5 steps step NNS cord-261417-4pf5nsw2 38 6 require require VBP cord-261417-4pf5nsw2 38 7 the the DT cord-261417-4pf5nsw2 38 8 combined combine VBN cord-261417-4pf5nsw2 38 9 action action NN cord-261417-4pf5nsw2 38 10 of of IN cord-261417-4pf5nsw2 38 11 basal basal NN cord-261417-4pf5nsw2 38 12 transcription transcription NN cord-261417-4pf5nsw2 38 13 factors factor NNS cord-261417-4pf5nsw2 38 14 ( ( -LRB- cord-261417-4pf5nsw2 38 15 TF TF NNP cord-261417-4pf5nsw2 38 16 ) ) -RRB- cord-261417-4pf5nsw2 39 1 ( ( -LRB- cord-261417-4pf5nsw2 39 2 Figure figure NN cord-261417-4pf5nsw2 39 3 1 1 CD cord-261417-4pf5nsw2 39 4 ) ) -RRB- cord-261417-4pf5nsw2 39 5 [ [ -LRB- cord-261417-4pf5nsw2 39 6 21 21 CD cord-261417-4pf5nsw2 39 7 , , , cord-261417-4pf5nsw2 39 8 22 22 CD cord-261417-4pf5nsw2 39 9 ] ] -RRB- cord-261417-4pf5nsw2 39 10 . . . cord-261417-4pf5nsw2 40 1 The the DT cord-261417-4pf5nsw2 40 2 minimal minimal JJ cord-261417-4pf5nsw2 40 3 pre pre JJ cord-261417-4pf5nsw2 40 4 - - JJ cord-261417-4pf5nsw2 40 5 initiation initiation JJ cord-261417-4pf5nsw2 40 6 complex complex NN cord-261417-4pf5nsw2 40 7 ( ( -LRB- cord-261417-4pf5nsw2 40 8 PIC pic NN cord-261417-4pf5nsw2 40 9 ) ) -RRB- cord-261417-4pf5nsw2 40 10 includes include VBZ cord-261417-4pf5nsw2 40 11 RNAPII RNAPII NNP cord-261417-4pf5nsw2 40 12 and and CC cord-261417-4pf5nsw2 40 13 six six CD cord-261417-4pf5nsw2 40 14 general general JJ cord-261417-4pf5nsw2 40 15 transcription transcription NN cord-261417-4pf5nsw2 40 16 factors factor NNS cord-261417-4pf5nsw2 40 17 : : : cord-261417-4pf5nsw2 40 18 TFIIA TFIIA NNP cord-261417-4pf5nsw2 40 19 , , , cord-261417-4pf5nsw2 40 20 TFIIB TFIIB NNP cord-261417-4pf5nsw2 40 21 , , , cord-261417-4pf5nsw2 40 22 TFIID TFIID NNP cord-261417-4pf5nsw2 40 23 , , , cord-261417-4pf5nsw2 40 24 TFIIE TFIIE NNP cord-261417-4pf5nsw2 40 25 , , , cord-261417-4pf5nsw2 40 26 TFIIF TFIIF NNP cord-261417-4pf5nsw2 40 27 , , , cord-261417-4pf5nsw2 40 28 and and CC cord-261417-4pf5nsw2 40 29 TFIIH TFIIH NNP cord-261417-4pf5nsw2 40 30 . . . cord-261417-4pf5nsw2 41 1 First first RB cord-261417-4pf5nsw2 41 2 , , , cord-261417-4pf5nsw2 41 3 TFIID TFIID NNP cord-261417-4pf5nsw2 41 4 containing contain VBG cord-261417-4pf5nsw2 41 5 the the DT cord-261417-4pf5nsw2 41 6 TATA TATA NNP cord-261417-4pf5nsw2 41 7 - - HYPH cord-261417-4pf5nsw2 41 8 binding bind VBG cord-261417-4pf5nsw2 41 9 protein protein NN cord-261417-4pf5nsw2 41 10 ( ( -LRB- cord-261417-4pf5nsw2 41 11 TBP TBP NNP cord-261417-4pf5nsw2 41 12 ) ) -RRB- cord-261417-4pf5nsw2 41 13 is be VBZ cord-261417-4pf5nsw2 41 14 recruited recruit VBN cord-261417-4pf5nsw2 41 15 to to IN cord-261417-4pf5nsw2 41 16 TATA TATA NNP cord-261417-4pf5nsw2 41 17 box box NN cord-261417-4pf5nsw2 41 18 containing contain VBG cord-261417-4pf5nsw2 41 19 promoter promoter NN cord-261417-4pf5nsw2 41 20 sequences sequence NNS cord-261417-4pf5nsw2 41 21 ( ( -LRB- cord-261417-4pf5nsw2 41 22 Figure figure NN cord-261417-4pf5nsw2 41 23 1 1 CD cord-261417-4pf5nsw2 41 24 ) ) -RRB- cord-261417-4pf5nsw2 41 25 [ [ -LRB- cord-261417-4pf5nsw2 41 26 23 23 CD cord-261417-4pf5nsw2 41 27 ] ] -RRB- cord-261417-4pf5nsw2 41 28 [ [ -LRB- cord-261417-4pf5nsw2 41 29 24 24 CD cord-261417-4pf5nsw2 41 30 ] ] -RRB- cord-261417-4pf5nsw2 41 31 [ [ -LRB- cord-261417-4pf5nsw2 41 32 25 25 CD cord-261417-4pf5nsw2 41 33 ] ] -RRB- cord-261417-4pf5nsw2 41 34 . . . cord-261417-4pf5nsw2 42 1 The the DT cord-261417-4pf5nsw2 42 2 binding binding NN cord-261417-4pf5nsw2 42 3 of of IN cord-261417-4pf5nsw2 42 4 TFIID TFIID NNP cord-261417-4pf5nsw2 42 5 to to IN cord-261417-4pf5nsw2 42 6 the the DT cord-261417-4pf5nsw2 42 7 TATA TATA NNP cord-261417-4pf5nsw2 42 8 box box NN cord-261417-4pf5nsw2 42 9 in in IN cord-261417-4pf5nsw2 42 10 the the DT cord-261417-4pf5nsw2 42 11 promoter promoter NN cord-261417-4pf5nsw2 42 12 region region NN cord-261417-4pf5nsw2 42 13 of of IN cord-261417-4pf5nsw2 42 14 the the DT cord-261417-4pf5nsw2 42 15 gene gene NN cord-261417-4pf5nsw2 42 16 initiates initiate VBZ cord-261417-4pf5nsw2 42 17 the the DT cord-261417-4pf5nsw2 42 18 recruitment recruitment NN cord-261417-4pf5nsw2 42 19 of of IN cord-261417-4pf5nsw2 42 20 TFIIB TFIIB NNP cord-261417-4pf5nsw2 42 21 , , , cord-261417-4pf5nsw2 42 22 TFIIE TFIIE NNP cord-261417-4pf5nsw2 42 23 , , , cord-261417-4pf5nsw2 42 24 TFIIF TFIIF NNP cord-261417-4pf5nsw2 42 25 and and CC cord-261417-4pf5nsw2 42 26 TFIIH TFIIH NNP cord-261417-4pf5nsw2 42 27 , , , cord-261417-4pf5nsw2 42 28 which which WDT cord-261417-4pf5nsw2 42 29 position position VBP cord-261417-4pf5nsw2 42 30 the the DT cord-261417-4pf5nsw2 42 31 double double RB cord-261417-4pf5nsw2 42 32 - - HYPH cord-261417-4pf5nsw2 42 33 stranded stranded JJ cord-261417-4pf5nsw2 42 34 ( ( -LRB- cord-261417-4pf5nsw2 42 35 ds ds NNP cord-261417-4pf5nsw2 42 36 ) ) -RRB- cord-261417-4pf5nsw2 42 37 DNA DNA NNP cord-261417-4pf5nsw2 42 38 above above IN cord-261417-4pf5nsw2 42 39 the the DT cord-261417-4pf5nsw2 42 40 cleft cleft NN cord-261417-4pf5nsw2 42 41 within within IN cord-261417-4pf5nsw2 42 42 RNAPII RNAPII NNP cord-261417-4pf5nsw2 42 43 [ [ -LRB- cord-261417-4pf5nsw2 42 44 26 26 CD cord-261417-4pf5nsw2 42 45 ] ] -RRB- cord-261417-4pf5nsw2 42 46 [ [ -LRB- cord-261417-4pf5nsw2 42 47 27 27 CD cord-261417-4pf5nsw2 42 48 ] ] -RRB- cord-261417-4pf5nsw2 42 49 [ [ -LRB- cord-261417-4pf5nsw2 42 50 28 28 CD cord-261417-4pf5nsw2 42 51 ] ] -RRB- cord-261417-4pf5nsw2 42 52 . . . cord-261417-4pf5nsw2 43 1 Local local JJ cord-261417-4pf5nsw2 43 2 unwinding unwinding NN cord-261417-4pf5nsw2 43 3 of of IN cord-261417-4pf5nsw2 43 4 the the DT cord-261417-4pf5nsw2 43 5 dsDNA dsdna NN cord-261417-4pf5nsw2 43 6 by by IN cord-261417-4pf5nsw2 43 7 the the DT cord-261417-4pf5nsw2 43 8 Ssl2 Ssl2 NNP cord-261417-4pf5nsw2 43 9 helicase helicase NN cord-261417-4pf5nsw2 43 10 subunit subunit NN cord-261417-4pf5nsw2 43 11 of of IN cord-261417-4pf5nsw2 43 12 TFIIH TFIIH NNP cord-261417-4pf5nsw2 43 13 delivers deliver VBZ cord-261417-4pf5nsw2 43 14 the the DT cord-261417-4pf5nsw2 43 15 template template NN cord-261417-4pf5nsw2 43 16 strand strand NN cord-261417-4pf5nsw2 43 17 into into IN cord-261417-4pf5nsw2 43 18 the the DT cord-261417-4pf5nsw2 43 19 RNAPII RNAPII NNP cord-261417-4pf5nsw2 43 20 active active JJ cord-261417-4pf5nsw2 43 21 center center NN cord-261417-4pf5nsw2 43 22 and and CC cord-261417-4pf5nsw2 43 23 creates create VBZ cord-261417-4pf5nsw2 43 24 a a DT cord-261417-4pf5nsw2 43 25 DNA dna NN cord-261417-4pf5nsw2 43 26 bubble bubble NN cord-261417-4pf5nsw2 43 27 downstream downstream NN cord-261417-4pf5nsw2 43 28 of of IN cord-261417-4pf5nsw2 43 29 the the DT cord-261417-4pf5nsw2 43 30 TATA TATA NNP cord-261417-4pf5nsw2 43 31 box box NN cord-261417-4pf5nsw2 43 32 [ [ -LRB- cord-261417-4pf5nsw2 43 33 29 29 CD cord-261417-4pf5nsw2 43 34 ] ] -RRB- cord-261417-4pf5nsw2 43 35 . . . cord-261417-4pf5nsw2 44 1 Efficient efficient JJ cord-261417-4pf5nsw2 44 2 DNA dna NN cord-261417-4pf5nsw2 44 3 opening opening NN cord-261417-4pf5nsw2 44 4 requires require VBZ cord-261417-4pf5nsw2 44 5 TFIIE TFIIE NNP cord-261417-4pf5nsw2 44 6 and and CC cord-261417-4pf5nsw2 44 7 TFIIH TFIIH NNP cord-261417-4pf5nsw2 44 8 , , , cord-261417-4pf5nsw2 44 9 but but CC cord-261417-4pf5nsw2 44 10 these these DT cord-261417-4pf5nsw2 44 11 factors factor NNS cord-261417-4pf5nsw2 44 12 are be VBP cord-261417-4pf5nsw2 44 13 not not RB cord-261417-4pf5nsw2 44 14 required require VBN cord-261417-4pf5nsw2 44 15 for for IN cord-261417-4pf5nsw2 44 16 low low JJ cord-261417-4pf5nsw2 44 17 levels level NNS cord-261417-4pf5nsw2 44 18 of of IN cord-261417-4pf5nsw2 44 19 transcription transcription NN cord-261417-4pf5nsw2 44 20 [ [ -LRB- cord-261417-4pf5nsw2 44 21 30 30 CD cord-261417-4pf5nsw2 44 22 ] ] -RRB- cord-261417-4pf5nsw2 44 23 . . . cord-261417-4pf5nsw2 45 1 The the DT cord-261417-4pf5nsw2 45 2 TFIIK TFIIK NNP cord-261417-4pf5nsw2 45 3 kinase kinase NN cord-261417-4pf5nsw2 45 4 module module NN cord-261417-4pf5nsw2 45 5 of of IN cord-261417-4pf5nsw2 45 6 TFIIH TFIIH NNP cord-261417-4pf5nsw2 45 7 will will MD cord-261417-4pf5nsw2 45 8 subsequently subsequently RB cord-261417-4pf5nsw2 45 9 phosphorylate phosphorylate VB cord-261417-4pf5nsw2 45 10 RNAPII RNAPII NNP cord-261417-4pf5nsw2 45 11 on on IN cord-261417-4pf5nsw2 45 12 the the DT cord-261417-4pf5nsw2 45 13 Ser5 Ser5 NNP cord-261417-4pf5nsw2 45 14 of of IN cord-261417-4pf5nsw2 45 15 its -PRON- PRP$ cord-261417-4pf5nsw2 45 16 CTD CTD NNP cord-261417-4pf5nsw2 46 1 repeats repeat NNS cord-261417-4pf5nsw2 46 2 , , , cord-261417-4pf5nsw2 46 3 facilitating facilitate VBG cord-261417-4pf5nsw2 46 4 promoter promoter NN cord-261417-4pf5nsw2 46 5 clearance clearance NN cord-261417-4pf5nsw2 46 6 and and CC cord-261417-4pf5nsw2 46 7 starting start VBG cord-261417-4pf5nsw2 46 8 the the DT cord-261417-4pf5nsw2 46 9 elongation elongation NN cord-261417-4pf5nsw2 46 10 stage stage NN cord-261417-4pf5nsw2 46 11 [ [ -LRB- cord-261417-4pf5nsw2 46 12 31 31 CD cord-261417-4pf5nsw2 46 13 ] ] -RRB- cord-261417-4pf5nsw2 46 14 . . . cord-261417-4pf5nsw2 47 1 Whereas whereas IN cord-261417-4pf5nsw2 47 2 DNA dna NN cord-261417-4pf5nsw2 47 3 viruses virus NNS cord-261417-4pf5nsw2 47 4 only only RB cord-261417-4pf5nsw2 47 5 need need VBP cord-261417-4pf5nsw2 47 6 to to TO cord-261417-4pf5nsw2 47 7 generate generate VB cord-261417-4pf5nsw2 47 8 mRNA mRNA NNP cord-261417-4pf5nsw2 47 9 , , , cord-261417-4pf5nsw2 47 10 RNA RNA NNP cord-261417-4pf5nsw2 47 11 viruses virus NNS cord-261417-4pf5nsw2 47 12 without without IN cord-261417-4pf5nsw2 47 13 a a DT cord-261417-4pf5nsw2 47 14 DNA dna NN cord-261417-4pf5nsw2 47 15 stage stage NN cord-261417-4pf5nsw2 47 16 have have VBP cord-261417-4pf5nsw2 47 17 to to TO cord-261417-4pf5nsw2 47 18 synthesize synthesize VB cord-261417-4pf5nsw2 47 19 both both DT cord-261417-4pf5nsw2 47 20 vRNA vrna JJ cord-261417-4pf5nsw2 47 21 and and CC cord-261417-4pf5nsw2 47 22 mRNA mrna NN cord-261417-4pf5nsw2 47 23 . . . cord-261417-4pf5nsw2 48 1 The the DT cord-261417-4pf5nsw2 48 2 vRNA vRNA NNS cord-261417-4pf5nsw2 48 3 is be VBZ cord-261417-4pf5nsw2 48 4 generated generate VBN cord-261417-4pf5nsw2 48 5 through through IN cord-261417-4pf5nsw2 48 6 a a DT cord-261417-4pf5nsw2 48 7 replication replication NN cord-261417-4pf5nsw2 48 8 intermediate intermediate NN cord-261417-4pf5nsw2 48 9 , , , cord-261417-4pf5nsw2 48 10 named name VBN cord-261417-4pf5nsw2 48 11 antigenome antigenome NNP cord-261417-4pf5nsw2 48 12 which which WDT cord-261417-4pf5nsw2 48 13 serves serve VBZ cord-261417-4pf5nsw2 48 14 as as IN cord-261417-4pf5nsw2 48 15 a a DT cord-261417-4pf5nsw2 48 16 template template NN cord-261417-4pf5nsw2 48 17 for for IN cord-261417-4pf5nsw2 48 18 vRNA vrna JJ cord-261417-4pf5nsw2 48 19 synthesis synthesis NN cord-261417-4pf5nsw2 48 20 . . . cord-261417-4pf5nsw2 49 1 ssRNA ssrna UH cord-261417-4pf5nsw2 50 1 viruses virus NNS cord-261417-4pf5nsw2 50 2 evolved evolve VBN cord-261417-4pf5nsw2 51 1 modules module NNS cord-261417-4pf5nsw2 51 2 that that WDT cord-261417-4pf5nsw2 51 3 make make VBP cord-261417-4pf5nsw2 51 4 up up RP cord-261417-4pf5nsw2 51 5 the the DT cord-261417-4pf5nsw2 51 6 RNA RNA NNP cord-261417-4pf5nsw2 51 7 - - HYPH cord-261417-4pf5nsw2 51 8 exit exit NN cord-261417-4pf5nsw2 51 9 channel channel NN cord-261417-4pf5nsw2 51 10 are be VBP cord-261417-4pf5nsw2 51 11 depicted depict VBN cord-261417-4pf5nsw2 51 12 in in IN cord-261417-4pf5nsw2 51 13 pink pink JJ cord-261417-4pf5nsw2 51 14 and and CC cord-261417-4pf5nsw2 51 15 blue blue JJ cord-261417-4pf5nsw2 51 16 , , , cord-261417-4pf5nsw2 51 17 respectively respectively RB cord-261417-4pf5nsw2 51 18 . . . cord-261417-4pf5nsw2 52 1 The the DT cord-261417-4pf5nsw2 52 2 first first JJ cord-261417-4pf5nsw2 52 3 repeat repeat NN cord-261417-4pf5nsw2 52 4 of of IN cord-261417-4pf5nsw2 52 5 the the DT cord-261417-4pf5nsw2 52 6 RNAPII RNAPII NNP cord-261417-4pf5nsw2 52 7 C C NNP cord-261417-4pf5nsw2 52 8 - - HYPH cord-261417-4pf5nsw2 52 9 terminal terminal NN cord-261417-4pf5nsw2 52 10 domain domain NN cord-261417-4pf5nsw2 52 11 ( ( -LRB- cord-261417-4pf5nsw2 52 12 CTD CTD NNP cord-261417-4pf5nsw2 52 13 ) ) -RRB- cord-261417-4pf5nsw2 52 14 is be VBZ cord-261417-4pf5nsw2 52 15 shown show VBN cord-261417-4pf5nsw2 52 16 as as IN cord-261417-4pf5nsw2 52 17 a a DT cord-261417-4pf5nsw2 52 18 string string NN cord-261417-4pf5nsw2 52 19 of of IN cord-261417-4pf5nsw2 52 20 amino amino JJ cord-261417-4pf5nsw2 52 21 acids acid NNS cord-261417-4pf5nsw2 52 22 with with IN cord-261417-4pf5nsw2 52 23 their -PRON- PRP$ cord-261417-4pf5nsw2 52 24 respective respective JJ cord-261417-4pf5nsw2 52 25 numbers number NNS cord-261417-4pf5nsw2 52 26 . . . cord-261417-4pf5nsw2 53 1 Next next RB cord-261417-4pf5nsw2 53 2 , , , cord-261417-4pf5nsw2 53 3 the the DT cord-261417-4pf5nsw2 53 4 stages stage NNS cord-261417-4pf5nsw2 53 5 of of IN cord-261417-4pf5nsw2 53 6 the the DT cord-261417-4pf5nsw2 53 7 transcription transcription NN cord-261417-4pf5nsw2 53 8 cycle cycle NN cord-261417-4pf5nsw2 53 9 are be VBP cord-261417-4pf5nsw2 53 10 shown show VBN cord-261417-4pf5nsw2 53 11 , , , cord-261417-4pf5nsw2 53 12 with with IN cord-261417-4pf5nsw2 53 13 the the DT cord-261417-4pf5nsw2 53 14 viral viral JJ cord-261417-4pf5nsw2 53 15 interfering interfere VBG cord-261417-4pf5nsw2 53 16 mechanisms mechanism NNS cord-261417-4pf5nsw2 53 17 . . . cord-261417-4pf5nsw2 54 1 First first RB cord-261417-4pf5nsw2 54 2 , , , cord-261417-4pf5nsw2 54 3 general general JJ cord-261417-4pf5nsw2 54 4 transcription transcription NN cord-261417-4pf5nsw2 54 5 factors factor NNS cord-261417-4pf5nsw2 54 6 assemble assemble VBP cord-261417-4pf5nsw2 54 7 at at IN cord-261417-4pf5nsw2 54 8 the the DT cord-261417-4pf5nsw2 54 9 promoter promoter NN cord-261417-4pf5nsw2 54 10 and and CC cord-261417-4pf5nsw2 54 11 direct direct JJ cord-261417-4pf5nsw2 54 12 RNAPII RNAPII NNP cord-261417-4pf5nsw2 54 13 towards towards IN cord-261417-4pf5nsw2 54 14 the the DT cord-261417-4pf5nsw2 54 15 transcription transcription NN cord-261417-4pf5nsw2 54 16 start start NN cord-261417-4pf5nsw2 54 17 site site NN cord-261417-4pf5nsw2 54 18 . . . cord-261417-4pf5nsw2 55 1 Transcription transcription NN cord-261417-4pf5nsw2 55 2 factor factor NN cord-261417-4pf5nsw2 55 3 ( ( -LRB- cord-261417-4pf5nsw2 55 4 TF TF NNP cord-261417-4pf5nsw2 55 5 ) ) -RRB- cord-261417-4pf5nsw2 55 6 IIH IIH NNP cord-261417-4pf5nsw2 55 7 phosphorylates phosphorylate VBZ cord-261417-4pf5nsw2 55 8 the the DT cord-261417-4pf5nsw2 55 9 RNAPII RNAPII NNP cord-261417-4pf5nsw2 55 10 at at IN cord-261417-4pf5nsw2 55 11 Ser5 Ser5 NNP cord-261417-4pf5nsw2 55 12 ( ( -LRB- cord-261417-4pf5nsw2 55 13 black black JJ cord-261417-4pf5nsw2 55 14 asterisk asterisk NN cord-261417-4pf5nsw2 55 15 ) ) -RRB- cord-261417-4pf5nsw2 55 16 . . . cord-261417-4pf5nsw2 56 1 TFIIH TFIIH NNP cord-261417-4pf5nsw2 56 2 opens open VBZ cord-261417-4pf5nsw2 56 3 the the DT cord-261417-4pf5nsw2 56 4 DNA dna NN cord-261417-4pf5nsw2 56 5 template template NN cord-261417-4pf5nsw2 56 6 , , , cord-261417-4pf5nsw2 56 7 forming form VBG cord-261417-4pf5nsw2 56 8 the the DT cord-261417-4pf5nsw2 56 9 transcription transcription NN cord-261417-4pf5nsw2 56 10 bubble bubble NN cord-261417-4pf5nsw2 56 11 , , , cord-261417-4pf5nsw2 56 12 permitting permit VBG cord-261417-4pf5nsw2 56 13 RNAPII RNAPII NNP cord-261417-4pf5nsw2 56 14 to to TO cord-261417-4pf5nsw2 56 15 begin begin VB cord-261417-4pf5nsw2 56 16 transcribing transcribe VBG cord-261417-4pf5nsw2 56 17 RNA RNA NNP cord-261417-4pf5nsw2 56 18 in in IN cord-261417-4pf5nsw2 56 19 its -PRON- PRP$ cord-261417-4pf5nsw2 56 20 active active JJ cord-261417-4pf5nsw2 56 21 center center NN cord-261417-4pf5nsw2 56 22 ( ( -LRB- cord-261417-4pf5nsw2 56 23 yellow yellow JJ cord-261417-4pf5nsw2 56 24 dot dot NN cord-261417-4pf5nsw2 56 25 ) ) -RRB- cord-261417-4pf5nsw2 56 26 . . . cord-261417-4pf5nsw2 57 1 Upon upon IN cord-261417-4pf5nsw2 57 2 transcribing transcribe VBG cord-261417-4pf5nsw2 57 3 the the DT cord-261417-4pf5nsw2 57 4 first first JJ cord-261417-4pf5nsw2 57 5 20 20 CD cord-261417-4pf5nsw2 57 6 - - SYM cord-261417-4pf5nsw2 57 7 60 60 CD cord-261417-4pf5nsw2 57 8 nucleotides nucleotide NNS cord-261417-4pf5nsw2 57 9 , , , cord-261417-4pf5nsw2 57 10 most most JJS cord-261417-4pf5nsw2 57 11 RNAP RNAP NNP cord-261417-4pf5nsw2 57 12 will will MD cord-261417-4pf5nsw2 57 13 pause pause VB cord-261417-4pf5nsw2 57 14 . . . cord-261417-4pf5nsw2 58 1 Transcription transcription NN cord-261417-4pf5nsw2 58 2 factor factor NN cord-261417-4pf5nsw2 58 3 recruitment recruitment NN cord-261417-4pf5nsw2 58 4 regulates regulate VBZ cord-261417-4pf5nsw2 58 5 these these DT cord-261417-4pf5nsw2 58 6 transcription transcription NN cord-261417-4pf5nsw2 58 7 kinetics kinetic NNS cord-261417-4pf5nsw2 58 8 and and CC cord-261417-4pf5nsw2 58 9 phosphorylate phosphorylate VB cord-261417-4pf5nsw2 58 10 RNAPII RNAPII NNP cord-261417-4pf5nsw2 58 11 at at IN cord-261417-4pf5nsw2 58 12 Ser2 Ser2 NNP cord-261417-4pf5nsw2 58 13 . . . cord-261417-4pf5nsw2 59 1 When when WRB cord-261417-4pf5nsw2 59 2 the the DT cord-261417-4pf5nsw2 59 3 correct correct JJ cord-261417-4pf5nsw2 59 4 signal signal NN cord-261417-4pf5nsw2 59 5 is be VBZ cord-261417-4pf5nsw2 59 6 encountered encounter VBN cord-261417-4pf5nsw2 59 7 , , , cord-261417-4pf5nsw2 59 8 RNAPII RNAPII NNP cord-261417-4pf5nsw2 59 9 will will MD cord-261417-4pf5nsw2 59 10 terminate terminate VB cord-261417-4pf5nsw2 59 11 transcription transcription NN cord-261417-4pf5nsw2 59 12 and and CC cord-261417-4pf5nsw2 59 13 release release VB cord-261417-4pf5nsw2 59 14 the the DT cord-261417-4pf5nsw2 59 15 RNA RNA NNP cord-261417-4pf5nsw2 59 16 . . . cord-261417-4pf5nsw2 60 1 Some some DT cord-261417-4pf5nsw2 60 2 viruses virus NNS cord-261417-4pf5nsw2 60 3 encode encode VBP cord-261417-4pf5nsw2 60 4 endonucleases endonuclease NNS cord-261417-4pf5nsw2 60 5 ( ( -LRB- cord-261417-4pf5nsw2 60 6 yellow yellow JJ cord-261417-4pf5nsw2 60 7 sphere sphere NN cord-261417-4pf5nsw2 60 8 with with IN cord-261417-4pf5nsw2 60 9 scissor scissor NNP cord-261417-4pf5nsw2 60 10 ) ) -RRB- cord-261417-4pf5nsw2 60 11 that that WDT cord-261417-4pf5nsw2 60 12 can can MD cord-261417-4pf5nsw2 60 13 cleave cleave VB cord-261417-4pf5nsw2 60 14 RNAs rna NNS cord-261417-4pf5nsw2 60 15 , , , cord-261417-4pf5nsw2 60 16 causing cause VBG cord-261417-4pf5nsw2 60 17 RNA RNA NNP cord-261417-4pf5nsw2 60 18 degradation degradation NN cord-261417-4pf5nsw2 60 19 . . . cord-261417-4pf5nsw2 61 1 Initiation initiation NN cord-261417-4pf5nsw2 61 2 is be VBZ cord-261417-4pf5nsw2 61 3 promoted promote VBN cord-261417-4pf5nsw2 61 4 by by IN cord-261417-4pf5nsw2 61 5 factors factor NNS cord-261417-4pf5nsw2 61 6 that that WDT cord-261417-4pf5nsw2 61 7 recruit recruit VBP cord-261417-4pf5nsw2 61 8 RNAP RNAP NNP cord-261417-4pf5nsw2 61 9 to to IN cord-261417-4pf5nsw2 61 10 the the DT cord-261417-4pf5nsw2 61 11 promoter promoter NN cord-261417-4pf5nsw2 61 12 , , , cord-261417-4pf5nsw2 61 13 melt melt VB cord-261417-4pf5nsw2 61 14 the the DT cord-261417-4pf5nsw2 61 15 DNA dna NN cord-261417-4pf5nsw2 61 16 duplex duplex NN cord-261417-4pf5nsw2 61 17 and and CC cord-261417-4pf5nsw2 61 18 load load VB cord-261417-4pf5nsw2 61 19 the the DT cord-261417-4pf5nsw2 61 20 template template NN cord-261417-4pf5nsw2 61 21 DNA dna NN cord-261417-4pf5nsw2 61 22 strand strand NN cord-261417-4pf5nsw2 61 23 into into IN cord-261417-4pf5nsw2 61 24 the the DT cord-261417-4pf5nsw2 61 25 active active JJ cord-261417-4pf5nsw2 61 26 site site NN cord-261417-4pf5nsw2 61 27 of of IN cord-261417-4pf5nsw2 61 28 RNAP RNAP NNP cord-261417-4pf5nsw2 61 29 . . . cord-261417-4pf5nsw2 62 1 For for IN cord-261417-4pf5nsw2 62 2 RNAPII RNAPII NNP cord-261417-4pf5nsw2 62 3 , , , cord-261417-4pf5nsw2 62 4 these these DT cord-261417-4pf5nsw2 62 5 steps step NNS cord-261417-4pf5nsw2 62 6 require require VBP cord-261417-4pf5nsw2 62 7 the the DT cord-261417-4pf5nsw2 62 8 combined combine VBN cord-261417-4pf5nsw2 62 9 action action NN cord-261417-4pf5nsw2 62 10 of of IN cord-261417-4pf5nsw2 62 11 basal basal NN cord-261417-4pf5nsw2 62 12 transcription transcription NN cord-261417-4pf5nsw2 62 13 factors factor NNS cord-261417-4pf5nsw2 62 14 ( ( -LRB- cord-261417-4pf5nsw2 62 15 TF TF NNP cord-261417-4pf5nsw2 62 16 ) ) -RRB- cord-261417-4pf5nsw2 63 1 ( ( -LRB- cord-261417-4pf5nsw2 63 2 Figure figure NN cord-261417-4pf5nsw2 63 3 1 1 CD cord-261417-4pf5nsw2 63 4 ) ) -RRB- cord-261417-4pf5nsw2 63 5 [ [ -LRB- cord-261417-4pf5nsw2 63 6 21 21 CD cord-261417-4pf5nsw2 63 7 , , , cord-261417-4pf5nsw2 63 8 22 22 CD cord-261417-4pf5nsw2 63 9 ] ] -RRB- cord-261417-4pf5nsw2 63 10 . . . cord-261417-4pf5nsw2 64 1 The the DT cord-261417-4pf5nsw2 64 2 minimal minimal JJ cord-261417-4pf5nsw2 64 3 pre pre JJ cord-261417-4pf5nsw2 64 4 - - JJ cord-261417-4pf5nsw2 64 5 initiation initiation JJ cord-261417-4pf5nsw2 64 6 complex complex NN cord-261417-4pf5nsw2 64 7 ( ( -LRB- cord-261417-4pf5nsw2 64 8 PIC pic NN cord-261417-4pf5nsw2 64 9 ) ) -RRB- cord-261417-4pf5nsw2 64 10 includes include VBZ cord-261417-4pf5nsw2 64 11 RNAPII RNAPII NNP cord-261417-4pf5nsw2 64 12 and and CC cord-261417-4pf5nsw2 64 13 six six CD cord-261417-4pf5nsw2 64 14 general general JJ cord-261417-4pf5nsw2 64 15 transcription transcription NN cord-261417-4pf5nsw2 64 16 factors factor NNS cord-261417-4pf5nsw2 64 17 : : : cord-261417-4pf5nsw2 64 18 TFIIA TFIIA NNP cord-261417-4pf5nsw2 64 19 , , , cord-261417-4pf5nsw2 64 20 TFIIB TFIIB NNP cord-261417-4pf5nsw2 64 21 , , , cord-261417-4pf5nsw2 64 22 TFIID TFIID NNP cord-261417-4pf5nsw2 64 23 , , , cord-261417-4pf5nsw2 64 24 TFIIE TFIIE NNP cord-261417-4pf5nsw2 64 25 , , , cord-261417-4pf5nsw2 64 26 TFIIF TFIIF NNP cord-261417-4pf5nsw2 64 27 , , , cord-261417-4pf5nsw2 64 28 and and CC cord-261417-4pf5nsw2 64 29 TFIIH TFIIH NNP cord-261417-4pf5nsw2 64 30 . . . cord-261417-4pf5nsw2 65 1 First first RB cord-261417-4pf5nsw2 65 2 , , , cord-261417-4pf5nsw2 65 3 TFIID TFIID NNP cord-261417-4pf5nsw2 65 4 containing contain VBG cord-261417-4pf5nsw2 65 5 the the DT cord-261417-4pf5nsw2 65 6 TATA TATA NNP cord-261417-4pf5nsw2 65 7 - - HYPH cord-261417-4pf5nsw2 65 8 binding bind VBG cord-261417-4pf5nsw2 65 9 protein protein NN cord-261417-4pf5nsw2 65 10 ( ( -LRB- cord-261417-4pf5nsw2 65 11 TBP TBP NNP cord-261417-4pf5nsw2 65 12 ) ) -RRB- cord-261417-4pf5nsw2 65 13 is be VBZ cord-261417-4pf5nsw2 65 14 recruited recruit VBN cord-261417-4pf5nsw2 65 15 to to IN cord-261417-4pf5nsw2 65 16 TATA TATA NNP cord-261417-4pf5nsw2 65 17 box box NN cord-261417-4pf5nsw2 65 18 containing contain VBG cord-261417-4pf5nsw2 65 19 promoter promoter NN cord-261417-4pf5nsw2 65 20 sequences sequence NNS cord-261417-4pf5nsw2 65 21 ( ( -LRB- cord-261417-4pf5nsw2 65 22 Figure figure NN cord-261417-4pf5nsw2 65 23 1 1 CD cord-261417-4pf5nsw2 65 24 ) ) -RRB- cord-261417-4pf5nsw2 65 25 [ [ -LRB- cord-261417-4pf5nsw2 65 26 23 23 CD cord-261417-4pf5nsw2 65 27 ] ] -RRB- cord-261417-4pf5nsw2 65 28 [ [ -LRB- cord-261417-4pf5nsw2 65 29 24 24 CD cord-261417-4pf5nsw2 65 30 ] ] -RRB- cord-261417-4pf5nsw2 65 31 [ [ -LRB- cord-261417-4pf5nsw2 65 32 25 25 CD cord-261417-4pf5nsw2 65 33 ] ] -RRB- cord-261417-4pf5nsw2 65 34 . . . cord-261417-4pf5nsw2 66 1 The the DT cord-261417-4pf5nsw2 66 2 binding binding NN cord-261417-4pf5nsw2 66 3 of of IN cord-261417-4pf5nsw2 66 4 TFIID TFIID NNP cord-261417-4pf5nsw2 66 5 to to IN cord-261417-4pf5nsw2 66 6 the the DT cord-261417-4pf5nsw2 66 7 TATA TATA NNP cord-261417-4pf5nsw2 66 8 box box NN cord-261417-4pf5nsw2 66 9 in in IN cord-261417-4pf5nsw2 66 10 the the DT cord-261417-4pf5nsw2 66 11 promoter promoter NN cord-261417-4pf5nsw2 66 12 region region NN cord-261417-4pf5nsw2 66 13 of of IN cord-261417-4pf5nsw2 66 14 the the DT cord-261417-4pf5nsw2 66 15 gene gene NN cord-261417-4pf5nsw2 66 16 initiates initiate VBZ cord-261417-4pf5nsw2 66 17 the the DT cord-261417-4pf5nsw2 66 18 recruitment recruitment NN cord-261417-4pf5nsw2 66 19 of of IN cord-261417-4pf5nsw2 66 20 TFIIB TFIIB NNP cord-261417-4pf5nsw2 66 21 , , , cord-261417-4pf5nsw2 66 22 TFIIE TFIIE NNP cord-261417-4pf5nsw2 66 23 , , , cord-261417-4pf5nsw2 66 24 TFIIF TFIIF NNP cord-261417-4pf5nsw2 66 25 and and CC cord-261417-4pf5nsw2 66 26 TFIIH TFIIH NNP cord-261417-4pf5nsw2 66 27 , , , cord-261417-4pf5nsw2 66 28 which which WDT cord-261417-4pf5nsw2 66 29 position position VBP cord-261417-4pf5nsw2 66 30 the the DT cord-261417-4pf5nsw2 66 31 double double RB cord-261417-4pf5nsw2 66 32 - - HYPH cord-261417-4pf5nsw2 66 33 stranded stranded JJ cord-261417-4pf5nsw2 66 34 ( ( -LRB- cord-261417-4pf5nsw2 66 35 ds ds NNP cord-261417-4pf5nsw2 66 36 ) ) -RRB- cord-261417-4pf5nsw2 66 37 DNA DNA NNP cord-261417-4pf5nsw2 66 38 above above IN cord-261417-4pf5nsw2 66 39 the the DT cord-261417-4pf5nsw2 66 40 cleft cleft NN cord-261417-4pf5nsw2 66 41 within within IN cord-261417-4pf5nsw2 66 42 RNAPII RNAPII NNP cord-261417-4pf5nsw2 66 43 [ [ -LRB- cord-261417-4pf5nsw2 66 44 26 26 CD cord-261417-4pf5nsw2 66 45 ] ] -RRB- cord-261417-4pf5nsw2 66 46 [ [ -LRB- cord-261417-4pf5nsw2 66 47 27 27 CD cord-261417-4pf5nsw2 66 48 ] ] -RRB- cord-261417-4pf5nsw2 66 49 [ [ -LRB- cord-261417-4pf5nsw2 66 50 28 28 CD cord-261417-4pf5nsw2 66 51 ] ] -RRB- cord-261417-4pf5nsw2 66 52 . . . cord-261417-4pf5nsw2 67 1 Local local JJ cord-261417-4pf5nsw2 67 2 unwinding unwinding NN cord-261417-4pf5nsw2 67 3 of of IN cord-261417-4pf5nsw2 67 4 the the DT cord-261417-4pf5nsw2 67 5 dsDNA dsdna NN cord-261417-4pf5nsw2 67 6 by by IN cord-261417-4pf5nsw2 67 7 the the DT cord-261417-4pf5nsw2 67 8 Ssl2 Ssl2 NNP cord-261417-4pf5nsw2 67 9 helicase helicase NN cord-261417-4pf5nsw2 67 10 subunit subunit NN cord-261417-4pf5nsw2 67 11 of of IN cord-261417-4pf5nsw2 67 12 TFIIH TFIIH NNP cord-261417-4pf5nsw2 67 13 delivers deliver VBZ cord-261417-4pf5nsw2 67 14 the the DT cord-261417-4pf5nsw2 67 15 template template NN cord-261417-4pf5nsw2 67 16 strand strand NN cord-261417-4pf5nsw2 67 17 into into IN cord-261417-4pf5nsw2 67 18 the the DT cord-261417-4pf5nsw2 67 19 RNAPII RNAPII NNP cord-261417-4pf5nsw2 67 20 active active JJ cord-261417-4pf5nsw2 67 21 center center NN cord-261417-4pf5nsw2 67 22 and and CC cord-261417-4pf5nsw2 67 23 creates create VBZ cord-261417-4pf5nsw2 67 24 a a DT cord-261417-4pf5nsw2 67 25 DNA dna NN cord-261417-4pf5nsw2 67 26 bubble bubble NN cord-261417-4pf5nsw2 67 27 downstream downstream NN cord-261417-4pf5nsw2 67 28 of of IN cord-261417-4pf5nsw2 67 29 the the DT cord-261417-4pf5nsw2 67 30 TATA TATA NNP cord-261417-4pf5nsw2 67 31 box box NN cord-261417-4pf5nsw2 67 32 [ [ -LRB- cord-261417-4pf5nsw2 67 33 29 29 CD cord-261417-4pf5nsw2 67 34 ] ] -RRB- cord-261417-4pf5nsw2 67 35 . . . cord-261417-4pf5nsw2 68 1 Efficient efficient JJ cord-261417-4pf5nsw2 68 2 DNA dna NN cord-261417-4pf5nsw2 68 3 opening opening NN cord-261417-4pf5nsw2 68 4 requires require VBZ cord-261417-4pf5nsw2 68 5 TFIIE TFIIE NNP cord-261417-4pf5nsw2 68 6 and and CC cord-261417-4pf5nsw2 68 7 TFIIH TFIIH NNP cord-261417-4pf5nsw2 68 8 , , , cord-261417-4pf5nsw2 68 9 but but CC cord-261417-4pf5nsw2 68 10 these these DT cord-261417-4pf5nsw2 68 11 factors factor NNS cord-261417-4pf5nsw2 68 12 are be VBP cord-261417-4pf5nsw2 68 13 not not RB cord-261417-4pf5nsw2 68 14 required require VBN cord-261417-4pf5nsw2 68 15 for for IN cord-261417-4pf5nsw2 68 16 low low JJ cord-261417-4pf5nsw2 68 17 levels level NNS cord-261417-4pf5nsw2 68 18 of of IN cord-261417-4pf5nsw2 68 19 transcription transcription NN cord-261417-4pf5nsw2 68 20 [ [ -LRB- cord-261417-4pf5nsw2 68 21 30 30 CD cord-261417-4pf5nsw2 68 22 ] ] -RRB- cord-261417-4pf5nsw2 68 23 . . . cord-261417-4pf5nsw2 69 1 The the DT cord-261417-4pf5nsw2 69 2 TFIIK TFIIK NNP cord-261417-4pf5nsw2 69 3 kinase kinase NN cord-261417-4pf5nsw2 69 4 module module NN cord-261417-4pf5nsw2 69 5 of of IN cord-261417-4pf5nsw2 69 6 TFIIH TFIIH NNP cord-261417-4pf5nsw2 69 7 will will MD cord-261417-4pf5nsw2 69 8 subsequently subsequently RB cord-261417-4pf5nsw2 69 9 phosphorylate phosphorylate VB cord-261417-4pf5nsw2 69 10 RNAPII RNAPII NNP cord-261417-4pf5nsw2 69 11 on on IN cord-261417-4pf5nsw2 69 12 the the DT cord-261417-4pf5nsw2 69 13 Ser5 Ser5 NNP cord-261417-4pf5nsw2 69 14 of of IN cord-261417-4pf5nsw2 69 15 its -PRON- PRP$ cord-261417-4pf5nsw2 69 16 CTD CTD NNP cord-261417-4pf5nsw2 70 1 repeats repeat NNS cord-261417-4pf5nsw2 70 2 , , , cord-261417-4pf5nsw2 70 3 facilitating facilitate VBG cord-261417-4pf5nsw2 70 4 promoter promoter NN cord-261417-4pf5nsw2 70 5 clearance clearance NN cord-261417-4pf5nsw2 70 6 and and CC cord-261417-4pf5nsw2 70 7 starting start VBG cord-261417-4pf5nsw2 70 8 the the DT cord-261417-4pf5nsw2 70 9 elongation elongation NN cord-261417-4pf5nsw2 70 10 stage stage NN cord-261417-4pf5nsw2 70 11 [ [ -LRB- cord-261417-4pf5nsw2 70 12 31 31 CD cord-261417-4pf5nsw2 70 13 ] ] -RRB- cord-261417-4pf5nsw2 70 14 . . . cord-261417-4pf5nsw2 71 1 Whereas whereas IN cord-261417-4pf5nsw2 71 2 DNA dna NN cord-261417-4pf5nsw2 71 3 viruses virus NNS cord-261417-4pf5nsw2 71 4 only only RB cord-261417-4pf5nsw2 71 5 need need VBP cord-261417-4pf5nsw2 71 6 to to TO cord-261417-4pf5nsw2 71 7 generate generate VB cord-261417-4pf5nsw2 71 8 mRNA mRNA NNP cord-261417-4pf5nsw2 71 9 , , , cord-261417-4pf5nsw2 71 10 RNA RNA NNP cord-261417-4pf5nsw2 71 11 viruses virus NNS cord-261417-4pf5nsw2 71 12 without without IN cord-261417-4pf5nsw2 71 13 a a DT cord-261417-4pf5nsw2 71 14 DNA dna NN cord-261417-4pf5nsw2 71 15 stage stage NN cord-261417-4pf5nsw2 71 16 have have VBP cord-261417-4pf5nsw2 71 17 to to TO cord-261417-4pf5nsw2 71 18 synthesize synthesize VB cord-261417-4pf5nsw2 71 19 both both DT cord-261417-4pf5nsw2 71 20 vRNA vrna JJ cord-261417-4pf5nsw2 71 21 and and CC cord-261417-4pf5nsw2 71 22 mRNA mrna NN cord-261417-4pf5nsw2 71 23 . . . cord-261417-4pf5nsw2 72 1 The the DT cord-261417-4pf5nsw2 72 2 vRNA vRNA NNS cord-261417-4pf5nsw2 72 3 is be VBZ cord-261417-4pf5nsw2 72 4 generated generate VBN cord-261417-4pf5nsw2 72 5 through through IN cord-261417-4pf5nsw2 72 6 a a DT cord-261417-4pf5nsw2 72 7 replication replication NN cord-261417-4pf5nsw2 72 8 intermediate intermediate NN cord-261417-4pf5nsw2 72 9 , , , cord-261417-4pf5nsw2 72 10 named name VBN cord-261417-4pf5nsw2 72 11 antigenome antigenome NNP cord-261417-4pf5nsw2 72 12 which which WDT cord-261417-4pf5nsw2 72 13 serves serve VBZ cord-261417-4pf5nsw2 72 14 as as IN cord-261417-4pf5nsw2 72 15 a a DT cord-261417-4pf5nsw2 72 16 template template NN cord-261417-4pf5nsw2 72 17 for for IN cord-261417-4pf5nsw2 72 18 vRNA vrna JJ cord-261417-4pf5nsw2 72 19 synthesis synthesis NN cord-261417-4pf5nsw2 72 20 . . . cord-261417-4pf5nsw2 73 1 ssRNA ssrna UH cord-261417-4pf5nsw2 74 1 viruses virus NNS cord-261417-4pf5nsw2 74 2 evolved evolve VBD cord-261417-4pf5nsw2 74 3 sophisticated sophisticated JJ cord-261417-4pf5nsw2 74 4 approaches approach NNS cord-261417-4pf5nsw2 74 5 to to TO cord-261417-4pf5nsw2 74 6 generate generate VB cord-261417-4pf5nsw2 74 7 both both DT cord-261417-4pf5nsw2 74 8 RNA RNA NNP cord-261417-4pf5nsw2 74 9 species specie NNS cord-261417-4pf5nsw2 74 10 from from IN cord-261417-4pf5nsw2 74 11 one one CD cord-261417-4pf5nsw2 74 12 template template NN cord-261417-4pf5nsw2 74 13 . . . cord-261417-4pf5nsw2 75 1 Using use VBG cord-261417-4pf5nsw2 75 2 respiratory respiratory JJ cord-261417-4pf5nsw2 75 3 syncytial syncytial JJ cord-261417-4pf5nsw2 75 4 virus virus NN cord-261417-4pf5nsw2 75 5 ( ( -LRB- cord-261417-4pf5nsw2 75 6 RSV RSV NNP cord-261417-4pf5nsw2 75 7 ) ) -RRB- cord-261417-4pf5nsw2 75 8 as as IN cord-261417-4pf5nsw2 75 9 a a DT cord-261417-4pf5nsw2 75 10 model model NN cord-261417-4pf5nsw2 75 11 , , , cord-261417-4pf5nsw2 75 12 it -PRON- PRP cord-261417-4pf5nsw2 75 13 was be VBD cord-261417-4pf5nsw2 75 14 illustrated illustrate VBN cord-261417-4pf5nsw2 75 15 that that IN cord-261417-4pf5nsw2 75 16 RdRp RdRp NNP cord-261417-4pf5nsw2 75 17 has have VBZ cord-261417-4pf5nsw2 75 18 two two CD cord-261417-4pf5nsw2 75 19 RNA RNA NNP cord-261417-4pf5nsw2 75 20 synthesis synthesis NN cord-261417-4pf5nsw2 75 21 activities activity NNS cord-261417-4pf5nsw2 75 22 which which WDT cord-261417-4pf5nsw2 75 23 determine determine VBP cord-261417-4pf5nsw2 75 24 nascent nascent JJ cord-261417-4pf5nsw2 75 25 RNA RNA NNP cord-261417-4pf5nsw2 75 26 fate fate NN cord-261417-4pf5nsw2 75 27 . . . cord-261417-4pf5nsw2 76 1 RSV RSV NNP cord-261417-4pf5nsw2 76 2 is be VBZ cord-261417-4pf5nsw2 76 3 a a DT cord-261417-4pf5nsw2 76 4 −ssRNA −ssrna CD cord-261417-4pf5nsw2 76 5 virus virus NN cord-261417-4pf5nsw2 76 6 and and CC cord-261417-4pf5nsw2 76 7 the the DT cord-261417-4pf5nsw2 76 8 major major JJ cord-261417-4pf5nsw2 76 9 cause cause NN cord-261417-4pf5nsw2 76 10 of of IN cord-261417-4pf5nsw2 76 11 respiratory respiratory JJ cord-261417-4pf5nsw2 76 12 tract tract NN cord-261417-4pf5nsw2 76 13 disease disease NN cord-261417-4pf5nsw2 76 14 in in IN cord-261417-4pf5nsw2 76 15 infants infant NNS cord-261417-4pf5nsw2 76 16 and and CC cord-261417-4pf5nsw2 76 17 young young JJ cord-261417-4pf5nsw2 76 18 children child NNS cord-261417-4pf5nsw2 76 19 , , , cord-261417-4pf5nsw2 76 20 causing cause VBG cord-261417-4pf5nsw2 76 21 between between IN cord-261417-4pf5nsw2 76 22 66,000 66,000 CD cord-261417-4pf5nsw2 76 23 and and CC cord-261417-4pf5nsw2 76 24 199,000 199,000 CD cord-261417-4pf5nsw2 76 25 deaths death NNS cord-261417-4pf5nsw2 76 26 per per IN cord-261417-4pf5nsw2 76 27 year year NN cord-261417-4pf5nsw2 76 28 worldwide worldwide RB cord-261417-4pf5nsw2 76 29 [ [ -LRB- cord-261417-4pf5nsw2 76 30 32 32 CD cord-261417-4pf5nsw2 76 31 ] ] -RRB- cord-261417-4pf5nsw2 76 32 . . . cord-261417-4pf5nsw2 77 1 To to TO cord-261417-4pf5nsw2 77 2 differentiate differentiate VB cord-261417-4pf5nsw2 77 3 between between IN cord-261417-4pf5nsw2 77 4 Rd Rd NNP cord-261417-4pf5nsw2 77 5 - - HYPH cord-261417-4pf5nsw2 77 6 mRNA mRNA NNP cord-261417-4pf5nsw2 77 7 synthesis synthesis NN cord-261417-4pf5nsw2 77 8 and and CC cord-261417-4pf5nsw2 77 9 vRNA vrna JJ cord-261417-4pf5nsw2 77 10 replication replication NN cord-261417-4pf5nsw2 77 11 , , , cord-261417-4pf5nsw2 77 12 RdRp RdRp NNP cord-261417-4pf5nsw2 77 13 initiates initiate VBZ cord-261417-4pf5nsw2 77 14 at at IN cord-261417-4pf5nsw2 77 15 one one CD cord-261417-4pf5nsw2 77 16 of of IN cord-261417-4pf5nsw2 77 17 two two CD cord-261417-4pf5nsw2 77 18 different different JJ cord-261417-4pf5nsw2 77 19 start start NN cord-261417-4pf5nsw2 77 20 sites site NNS cord-261417-4pf5nsw2 77 21 within within IN cord-261417-4pf5nsw2 77 22 the the DT cord-261417-4pf5nsw2 77 23 promoter promoter NN cord-261417-4pf5nsw2 77 24 sequences sequence NNS cord-261417-4pf5nsw2 77 25 at at IN cord-261417-4pf5nsw2 77 26 the the DT cord-261417-4pf5nsw2 77 27 3 3 CD cord-261417-4pf5nsw2 77 28 end end NN cord-261417-4pf5nsw2 77 29 of of IN cord-261417-4pf5nsw2 77 30 the the DT cord-261417-4pf5nsw2 77 31 RSV RSV NNP cord-261417-4pf5nsw2 77 32 RNA RNA NNP cord-261417-4pf5nsw2 77 33 genome genome NN cord-261417-4pf5nsw2 77 34 . . . cord-261417-4pf5nsw2 78 1 Synthesis synthesis NN cord-261417-4pf5nsw2 78 2 of of IN cord-261417-4pf5nsw2 78 3 the the DT cord-261417-4pf5nsw2 78 4 antigenome antigenome NN cord-261417-4pf5nsw2 78 5 starts start VBZ cord-261417-4pf5nsw2 78 6 at at IN cord-261417-4pf5nsw2 78 7 the the DT cord-261417-4pf5nsw2 78 8 expected expect VBN cord-261417-4pf5nsw2 78 9 +1 +1 HYPH cord-261417-4pf5nsw2 78 10 site site NN cord-261417-4pf5nsw2 78 11 . . . cord-261417-4pf5nsw2 79 1 However however RB cord-261417-4pf5nsw2 79 2 , , , cord-261417-4pf5nsw2 79 3 the the DT cord-261417-4pf5nsw2 79 4 more more RBR cord-261417-4pf5nsw2 79 5 abundant abundant JJ cord-261417-4pf5nsw2 79 6 RNA RNA NNP cord-261417-4pf5nsw2 79 7 species specie NNS cord-261417-4pf5nsw2 79 8 in in IN cord-261417-4pf5nsw2 79 9 infected infected JJ cord-261417-4pf5nsw2 79 10 cells cell NNS cord-261417-4pf5nsw2 79 11 was be VBD cord-261417-4pf5nsw2 79 12 found find VBN cord-261417-4pf5nsw2 79 13 to to TO cord-261417-4pf5nsw2 79 14 initiate initiate VB cord-261417-4pf5nsw2 79 15 at at IN cord-261417-4pf5nsw2 79 16 the the DT cord-261417-4pf5nsw2 79 17 +3 +3 CD cord-261417-4pf5nsw2 79 18 site site NN cord-261417-4pf5nsw2 79 19 [ [ -LRB- cord-261417-4pf5nsw2 79 20 33 33 CD cord-261417-4pf5nsw2 79 21 ] ] -RRB- cord-261417-4pf5nsw2 79 22 . . . cord-261417-4pf5nsw2 80 1 RdRp RdRp NNP cord-261417-4pf5nsw2 80 2 's 's POS cord-261417-4pf5nsw2 80 3 that that WDT cord-261417-4pf5nsw2 80 4 initiate initiate VBP cord-261417-4pf5nsw2 80 5 at at IN cord-261417-4pf5nsw2 80 6 the the DT cord-261417-4pf5nsw2 80 7 +3 +3 CD cord-261417-4pf5nsw2 80 8 site site NN cord-261417-4pf5nsw2 80 9 are be VBP cord-261417-4pf5nsw2 80 10 unable unable JJ cord-261417-4pf5nsw2 80 11 to to TO cord-261417-4pf5nsw2 80 12 enter enter VB cord-261417-4pf5nsw2 80 13 a a DT cord-261417-4pf5nsw2 80 14 stable stable JJ cord-261417-4pf5nsw2 80 15 elongation elongation NN cord-261417-4pf5nsw2 80 16 mode mode NN cord-261417-4pf5nsw2 80 17 and and CC cord-261417-4pf5nsw2 80 18 release release VB cord-261417-4pf5nsw2 80 19 the the DT cord-261417-4pf5nsw2 80 20 RNA RNA NNP cord-261417-4pf5nsw2 80 21 after after IN cord-261417-4pf5nsw2 80 22 approximately approximately RB cord-261417-4pf5nsw2 80 23 20 20 CD cord-261417-4pf5nsw2 80 24 - - SYM cord-261417-4pf5nsw2 80 25 25 25 CD cord-261417-4pf5nsw2 80 26 nucleotides nucleotide NNS cord-261417-4pf5nsw2 80 27 . . . cord-261417-4pf5nsw2 81 1 Many many JJ cord-261417-4pf5nsw2 81 2 de de IN cord-261417-4pf5nsw2 81 3 novo novo NNP cord-261417-4pf5nsw2 81 4 transcription transcription NN cord-261417-4pf5nsw2 81 5 initiation initiation NN cord-261417-4pf5nsw2 81 6 events event NNS cord-261417-4pf5nsw2 81 7 by by IN cord-261417-4pf5nsw2 81 8 RdRp RdRp NNP cord-261417-4pf5nsw2 81 9 are be VBP cord-261417-4pf5nsw2 81 10 known know VBN cord-261417-4pf5nsw2 81 11 to to TO cord-261417-4pf5nsw2 81 12 generate generate VB cord-261417-4pf5nsw2 81 13 abortive abortive JJ cord-261417-4pf5nsw2 81 14 transcripts transcript NNS cord-261417-4pf5nsw2 81 15 during during IN cord-261417-4pf5nsw2 81 16 the the DT cord-261417-4pf5nsw2 81 17 initiation initiation NN cord-261417-4pf5nsw2 81 18 phase phase NN cord-261417-4pf5nsw2 81 19 of of IN cord-261417-4pf5nsw2 81 20 RNA RNA NNP cord-261417-4pf5nsw2 81 21 synthesis synthesis NN cord-261417-4pf5nsw2 81 22 [ [ -LRB- cord-261417-4pf5nsw2 81 23 34 34 CD cord-261417-4pf5nsw2 81 24 ] ] -RRB- cord-261417-4pf5nsw2 81 25 [ [ -LRB- cord-261417-4pf5nsw2 81 26 35 35 CD cord-261417-4pf5nsw2 81 27 ] ] -RRB- cord-261417-4pf5nsw2 81 28 [ [ -LRB- cord-261417-4pf5nsw2 81 29 36 36 CD cord-261417-4pf5nsw2 81 30 ] ] -RRB- cord-261417-4pf5nsw2 81 31 . . . cord-261417-4pf5nsw2 82 1 However however RB cord-261417-4pf5nsw2 82 2 , , , cord-261417-4pf5nsw2 82 3 the the DT cord-261417-4pf5nsw2 82 4 function function NN cord-261417-4pf5nsw2 82 5 of of IN cord-261417-4pf5nsw2 82 6 this this DT cord-261417-4pf5nsw2 82 7 small small JJ cord-261417-4pf5nsw2 82 8 RNA RNA NNP cord-261417-4pf5nsw2 82 9 is be VBZ cord-261417-4pf5nsw2 82 10 yet yet RB cord-261417-4pf5nsw2 82 11 unknown unknown JJ cord-261417-4pf5nsw2 82 12 . . . cord-261417-4pf5nsw2 83 1 It -PRON- PRP cord-261417-4pf5nsw2 83 2 has have VBZ cord-261417-4pf5nsw2 83 3 been be VBN cord-261417-4pf5nsw2 83 4 proposed propose VBN cord-261417-4pf5nsw2 83 5 that that DT cord-261417-4pf5nsw2 83 6 synthesis synthesis NN cord-261417-4pf5nsw2 83 7 of of IN cord-261417-4pf5nsw2 83 8 this this DT cord-261417-4pf5nsw2 83 9 small small JJ cord-261417-4pf5nsw2 83 10 abortive abortive JJ cord-261417-4pf5nsw2 83 11 RNA RNA NNP cord-261417-4pf5nsw2 83 12 allows allow VBZ cord-261417-4pf5nsw2 83 13 the the DT cord-261417-4pf5nsw2 83 14 polymerase polymerase NN cord-261417-4pf5nsw2 83 15 to to TO cord-261417-4pf5nsw2 83 16 break break VB cord-261417-4pf5nsw2 83 17 contacts contact NNS cord-261417-4pf5nsw2 83 18 with with IN cord-261417-4pf5nsw2 83 19 the the DT cord-261417-4pf5nsw2 83 20 promoter promoter NN cord-261417-4pf5nsw2 83 21 [ [ -LRB- cord-261417-4pf5nsw2 83 22 37 37 CD cord-261417-4pf5nsw2 83 23 ] ] -RRB- cord-261417-4pf5nsw2 83 24 . . . cord-261417-4pf5nsw2 84 1 After after IN cord-261417-4pf5nsw2 84 2 releasing release VBG cord-261417-4pf5nsw2 84 3 the the DT cord-261417-4pf5nsw2 84 4 small small JJ cord-261417-4pf5nsw2 84 5 RNA RNA NNP cord-261417-4pf5nsw2 84 6 , , , cord-261417-4pf5nsw2 84 7 the the DT cord-261417-4pf5nsw2 84 8 RSV RSV NNP cord-261417-4pf5nsw2 84 9 polymerase polymerase NN cord-261417-4pf5nsw2 84 10 can can MD cord-261417-4pf5nsw2 84 11 now now RB cord-261417-4pf5nsw2 84 12 scan scan VB cord-261417-4pf5nsw2 84 13 the the DT cord-261417-4pf5nsw2 84 14 template template NN cord-261417-4pf5nsw2 84 15 and and CC cord-261417-4pf5nsw2 84 16 locate locate VB cord-261417-4pf5nsw2 84 17 the the DT cord-261417-4pf5nsw2 84 18 conserved conserve VBN cord-261417-4pf5nsw2 84 19 gene gene NN cord-261417-4pf5nsw2 84 20 start start NN cord-261417-4pf5nsw2 84 21 signal signal NN cord-261417-4pf5nsw2 84 22 ( ( -LRB- cord-261417-4pf5nsw2 84 23 ~10 ~10 CD cord-261417-4pf5nsw2 84 24 - - SYM cord-261417-4pf5nsw2 84 25 13 13 CD cord-261417-4pf5nsw2 84 26 nt nt NN cord-261417-4pf5nsw2 84 27 ) ) -RRB- cord-261417-4pf5nsw2 84 28 of of IN cord-261417-4pf5nsw2 84 29 the the DT cord-261417-4pf5nsw2 84 30 first first JJ cord-261417-4pf5nsw2 84 31 gene gene NN cord-261417-4pf5nsw2 84 32 , , , cord-261417-4pf5nsw2 84 33 however however RB cord-261417-4pf5nsw2 84 34 the the DT cord-261417-4pf5nsw2 84 35 mechanism mechanism NN cord-261417-4pf5nsw2 84 36 behind behind IN cord-261417-4pf5nsw2 84 37 this this DT cord-261417-4pf5nsw2 84 38 transition transition NN cord-261417-4pf5nsw2 84 39 is be VBZ cord-261417-4pf5nsw2 84 40 unknown unknown JJ cord-261417-4pf5nsw2 84 41 [ [ -LRB- cord-261417-4pf5nsw2 84 42 38 38 CD cord-261417-4pf5nsw2 84 43 ] ] -RRB- cord-261417-4pf5nsw2 84 44 . . . cord-261417-4pf5nsw2 85 1 Here here RB cord-261417-4pf5nsw2 85 2 the the DT cord-261417-4pf5nsw2 85 3 polymerase polymerase NN cord-261417-4pf5nsw2 85 4 will will MD cord-261417-4pf5nsw2 85 5 reinitiate reinitiate VB cord-261417-4pf5nsw2 85 6 RNA RNA NNP cord-261417-4pf5nsw2 85 7 synthesis synthesis NN cord-261417-4pf5nsw2 85 8 , , , cord-261417-4pf5nsw2 85 9 cap cap VB cord-261417-4pf5nsw2 85 10 the the DT cord-261417-4pf5nsw2 85 11 5 5 CD cord-261417-4pf5nsw2 85 12 end end NN cord-261417-4pf5nsw2 85 13 of of IN cord-261417-4pf5nsw2 85 14 the the DT cord-261417-4pf5nsw2 85 15 mRNA mrna NN cord-261417-4pf5nsw2 85 16 and and CC cord-261417-4pf5nsw2 85 17 commit commit VB cord-261417-4pf5nsw2 85 18 the the DT cord-261417-4pf5nsw2 85 19 RdRp RdRp NNP cord-261417-4pf5nsw2 85 20 to to IN cord-261417-4pf5nsw2 85 21 Rd Rd NNP cord-261417-4pf5nsw2 85 22 - - HYPH cord-261417-4pf5nsw2 85 23 mRNA mRNA NNP cord-261417-4pf5nsw2 85 24 synthesis synthesis NN cord-261417-4pf5nsw2 85 25 . . . cord-261417-4pf5nsw2 86 1 The the DT cord-261417-4pf5nsw2 86 2 choice choice NN cord-261417-4pf5nsw2 86 3 between between IN cord-261417-4pf5nsw2 86 4 the the DT cord-261417-4pf5nsw2 86 5 +1 +1 NNS cord-261417-4pf5nsw2 86 6 and and CC cord-261417-4pf5nsw2 86 7 +3 +3 JJ cord-261417-4pf5nsw2 86 8 initiation initiation NN cord-261417-4pf5nsw2 86 9 site site NN cord-261417-4pf5nsw2 86 10 by by IN cord-261417-4pf5nsw2 86 11 RSV RSV NNP cord-261417-4pf5nsw2 86 12 RdRp RdRp NNP cord-261417-4pf5nsw2 86 13 seems seem VBZ cord-261417-4pf5nsw2 86 14 to to TO cord-261417-4pf5nsw2 86 15 be be VB cord-261417-4pf5nsw2 86 16 determined determine VBN cord-261417-4pf5nsw2 86 17 by by IN cord-261417-4pf5nsw2 86 18 the the DT cord-261417-4pf5nsw2 86 19 loading loading NN cord-261417-4pf5nsw2 86 20 of of IN cord-261417-4pf5nsw2 86 21 a a DT cord-261417-4pf5nsw2 86 22 specific specific JJ cord-261417-4pf5nsw2 86 23 nucleotide nucleotide JJ cord-261417-4pf5nsw2 86 24 and and CC cord-261417-4pf5nsw2 86 25 subsequent subsequent JJ cord-261417-4pf5nsw2 86 26 creation creation NN cord-261417-4pf5nsw2 86 27 of of IN cord-261417-4pf5nsw2 86 28 a a DT cord-261417-4pf5nsw2 86 29 dinucleotide dinucleotide NN cord-261417-4pf5nsw2 86 30 primer primer NN cord-261417-4pf5nsw2 86 31 complementary complementary JJ cord-261417-4pf5nsw2 86 32 to to IN cord-261417-4pf5nsw2 86 33 the the DT cord-261417-4pf5nsw2 86 34 specific specific JJ cord-261417-4pf5nsw2 86 35 initiation initiation NN cord-261417-4pf5nsw2 86 36 site site NN cord-261417-4pf5nsw2 86 37 [ [ -LRB- cord-261417-4pf5nsw2 86 38 37 37 CD cord-261417-4pf5nsw2 86 39 ] ] -RRB- cord-261417-4pf5nsw2 86 40 . . . cord-261417-4pf5nsw2 87 1 Remarkably remarkably RB cord-261417-4pf5nsw2 87 2 , , , cord-261417-4pf5nsw2 87 3 even even RB cord-261417-4pf5nsw2 87 4 when when WRB cord-261417-4pf5nsw2 87 5 the the DT cord-261417-4pf5nsw2 87 6 priming priming NN cord-261417-4pf5nsw2 87 7 site site NN cord-261417-4pf5nsw2 87 8 is be VBZ cord-261417-4pf5nsw2 87 9 mutated mutate VBN cord-261417-4pf5nsw2 87 10 or or CC cord-261417-4pf5nsw2 87 11 absent absent JJ cord-261417-4pf5nsw2 87 12 , , , cord-261417-4pf5nsw2 87 13 the the DT cord-261417-4pf5nsw2 87 14 enzyme enzyme NN cord-261417-4pf5nsw2 87 15 is be VBZ cord-261417-4pf5nsw2 87 16 able able JJ cord-261417-4pf5nsw2 87 17 to to TO cord-261417-4pf5nsw2 87 18 selectively selectively RB cord-261417-4pf5nsw2 87 19 synthesize synthesize VB cord-261417-4pf5nsw2 87 20 the the DT cord-261417-4pf5nsw2 87 21 original original JJ cord-261417-4pf5nsw2 87 22 dinucleotide dinucleotide NN cord-261417-4pf5nsw2 87 23 priming prime VBG cord-261417-4pf5nsw2 87 24 site site NN cord-261417-4pf5nsw2 87 25 at at IN cord-261417-4pf5nsw2 87 26 the the DT cord-261417-4pf5nsw2 87 27 3 3 CD cord-261417-4pf5nsw2 87 28 end end NN cord-261417-4pf5nsw2 87 29 of of IN cord-261417-4pf5nsw2 87 30 the the DT cord-261417-4pf5nsw2 87 31 viral viral JJ cord-261417-4pf5nsw2 87 32 RNA RNA NNP cord-261417-4pf5nsw2 87 33 , , , cord-261417-4pf5nsw2 87 34 explaining explain VBG cord-261417-4pf5nsw2 87 35 the the DT cord-261417-4pf5nsw2 87 36 strict strict JJ cord-261417-4pf5nsw2 87 37 conservation conservation NN cord-261417-4pf5nsw2 87 38 of of IN cord-261417-4pf5nsw2 87 39 the the DT cord-261417-4pf5nsw2 87 40 5 5 CD cord-261417-4pf5nsw2 87 41 -and -and SYM cord-261417-4pf5nsw2 87 42 3 3 CD cord-261417-4pf5nsw2 88 1 -end -end : cord-261417-4pf5nsw2 88 2 dinucleotides dinucleotide NNS cord-261417-4pf5nsw2 88 3 of of IN cord-261417-4pf5nsw2 88 4 both both DT cord-261417-4pf5nsw2 88 5 + + SYM cord-261417-4pf5nsw2 88 6 ss ss NNP cord-261417-4pf5nsw2 88 7 and and CC cord-261417-4pf5nsw2 88 8 −ssRNA −ssRNA NFP cord-261417-4pf5nsw2 88 9 viruses virus NNS cord-261417-4pf5nsw2 88 10 [ [ -LRB- cord-261417-4pf5nsw2 88 11 39 39 CD cord-261417-4pf5nsw2 88 12 ] ] -RRB- cord-261417-4pf5nsw2 88 13 . . . cord-261417-4pf5nsw2 89 1 It -PRON- PRP cord-261417-4pf5nsw2 89 2 has have VBZ cord-261417-4pf5nsw2 89 3 been be VBN cord-261417-4pf5nsw2 89 4 proposed propose VBN cord-261417-4pf5nsw2 89 5 that that IN cord-261417-4pf5nsw2 89 6 a a DT cord-261417-4pf5nsw2 89 7 domain domain NN cord-261417-4pf5nsw2 89 8 , , , cord-261417-4pf5nsw2 89 9 unique unique JJ cord-261417-4pf5nsw2 89 10 in in IN cord-261417-4pf5nsw2 89 11 de de NNP cord-261417-4pf5nsw2 89 12 novo novo NNP cord-261417-4pf5nsw2 89 13 initiating initiate VBG cord-261417-4pf5nsw2 89 14 RdRp RdRp NNP cord-261417-4pf5nsw2 89 15 's 's POS cord-261417-4pf5nsw2 89 16 , , , cord-261417-4pf5nsw2 89 17 named name VBN cord-261417-4pf5nsw2 89 18 " " `` cord-261417-4pf5nsw2 89 19 priming priming NN cord-261417-4pf5nsw2 89 20 loop loop NN cord-261417-4pf5nsw2 89 21 " " '' cord-261417-4pf5nsw2 89 22 ( ( -LRB- cord-261417-4pf5nsw2 89 23 T794 T794 VBN cord-261417-4pf5nsw2 89 24 to to IN cord-261417-4pf5nsw2 89 25 A799 a799 NN cord-261417-4pf5nsw2 89 26 ) ) -RRB- cord-261417-4pf5nsw2 89 27 regulates regulate VBZ cord-261417-4pf5nsw2 89 28 the the DT cord-261417-4pf5nsw2 89 29 accessibility accessibility NN cord-261417-4pf5nsw2 89 30 of of IN cord-261417-4pf5nsw2 89 31 the the DT cord-261417-4pf5nsw2 89 32 active active JJ cord-261417-4pf5nsw2 89 33 site site NN cord-261417-4pf5nsw2 89 34 of of IN cord-261417-4pf5nsw2 89 35 RdRp RdRp NNP cord-261417-4pf5nsw2 89 36 [ [ -LRB- cord-261417-4pf5nsw2 89 37 40 40 CD cord-261417-4pf5nsw2 89 38 ] ] -RRB- cord-261417-4pf5nsw2 89 39 . . . cord-261417-4pf5nsw2 90 1 An an DT cord-261417-4pf5nsw2 90 2 essential essential JJ cord-261417-4pf5nsw2 90 3 role role NN cord-261417-4pf5nsw2 90 4 during during IN cord-261417-4pf5nsw2 90 5 initiation initiation NN cord-261417-4pf5nsw2 90 6 is be VBZ cord-261417-4pf5nsw2 90 7 played play VBN cord-261417-4pf5nsw2 90 8 by by IN cord-261417-4pf5nsw2 90 9 the the DT cord-261417-4pf5nsw2 90 10 residue residue NN cord-261417-4pf5nsw2 90 11 H798 h798 NN cord-261417-4pf5nsw2 90 12 of of IN cord-261417-4pf5nsw2 90 13 the the DT cord-261417-4pf5nsw2 90 14 priming priming NN cord-261417-4pf5nsw2 90 15 loop loop NN cord-261417-4pf5nsw2 90 16 , , , cord-261417-4pf5nsw2 90 17 by by IN cord-261417-4pf5nsw2 90 18 providing provide VBG cord-261417-4pf5nsw2 90 19 a a DT cord-261417-4pf5nsw2 90 20 platform platform NN cord-261417-4pf5nsw2 90 21 to to TO cord-261417-4pf5nsw2 90 22 which which WDT cord-261417-4pf5nsw2 90 23 the the DT cord-261417-4pf5nsw2 90 24 base base NN cord-261417-4pf5nsw2 90 25 of of IN cord-261417-4pf5nsw2 90 26 the the DT cord-261417-4pf5nsw2 90 27 priming prime VBG cord-261417-4pf5nsw2 90 28 ATP ATP NNP cord-261417-4pf5nsw2 90 29 could could MD cord-261417-4pf5nsw2 90 30 establish establish VB cord-261417-4pf5nsw2 90 31 a a DT cord-261417-4pf5nsw2 90 32 stacking stacking NN cord-261417-4pf5nsw2 90 33 interaction interaction NN cord-261417-4pf5nsw2 90 34 [ [ -LRB- cord-261417-4pf5nsw2 90 35 39 39 CD cord-261417-4pf5nsw2 90 36 ] ] -RRB- cord-261417-4pf5nsw2 90 37 . . . cord-261417-4pf5nsw2 91 1 These these DT cord-261417-4pf5nsw2 91 2 conservational conservational JJ cord-261417-4pf5nsw2 91 3 mechanisms mechanism NNS cord-261417-4pf5nsw2 91 4 , , , cord-261417-4pf5nsw2 91 5 mediated mediate VBN cord-261417-4pf5nsw2 91 6 by by IN cord-261417-4pf5nsw2 91 7 the the DT cord-261417-4pf5nsw2 91 8 polymerase polymerase NN cord-261417-4pf5nsw2 91 9 alone alone RB cord-261417-4pf5nsw2 91 10 have have VBP cord-261417-4pf5nsw2 91 11 been be VBN cord-261417-4pf5nsw2 91 12 suggested suggest VBN cord-261417-4pf5nsw2 91 13 to to TO cord-261417-4pf5nsw2 91 14 be be VB cord-261417-4pf5nsw2 91 15 used use VBN cord-261417-4pf5nsw2 91 16 by by IN cord-261417-4pf5nsw2 91 17 several several JJ cord-261417-4pf5nsw2 91 18 ssRNA ssrna NN cord-261417-4pf5nsw2 91 19 viruses virus NNS cord-261417-4pf5nsw2 91 20 [ [ -LRB- cord-261417-4pf5nsw2 91 21 41 41 CD cord-261417-4pf5nsw2 91 22 , , , cord-261417-4pf5nsw2 91 23 42 42 CD cord-261417-4pf5nsw2 91 24 ] ] -RRB- cord-261417-4pf5nsw2 91 25 . . . cord-261417-4pf5nsw2 92 1 5 5 LS cord-261417-4pf5nsw2 92 2 -terminal -terminal JJ cord-261417-4pf5nsw2 92 3 capping capping NN cord-261417-4pf5nsw2 92 4 of of IN cord-261417-4pf5nsw2 92 5 eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 92 6 mRNAs mRNAs NNPS cord-261417-4pf5nsw2 92 7 is be VBZ cord-261417-4pf5nsw2 92 8 probably probably RB cord-261417-4pf5nsw2 92 9 the the DT cord-261417-4pf5nsw2 92 10 first first JJ cord-261417-4pf5nsw2 92 11 co co JJ cord-261417-4pf5nsw2 92 12 - - JJ cord-261417-4pf5nsw2 92 13 transcriptional transcriptional JJ cord-261417-4pf5nsw2 92 14 RNA RNA NNP cord-261417-4pf5nsw2 92 15 processing processing NN cord-261417-4pf5nsw2 92 16 event event NN cord-261417-4pf5nsw2 92 17 . . . cord-261417-4pf5nsw2 93 1 Formation formation NN cord-261417-4pf5nsw2 93 2 of of IN cord-261417-4pf5nsw2 93 3 the the DT cord-261417-4pf5nsw2 93 4 5 5 CD cord-261417-4pf5nsw2 93 5 -terminal -terminal JJ cord-261417-4pf5nsw2 93 6 cap cap NN cord-261417-4pf5nsw2 93 7 structure structure NN cord-261417-4pf5nsw2 93 8 ( ( -LRB- cord-261417-4pf5nsw2 93 9 m7Gppp[5 m7Gppp[5 NNP cord-261417-4pf5nsw2 93 10 ] ] -RRB- cord-261417-4pf5nsw2 93 11 N- N- NNP cord-261417-4pf5nsw2 93 12 ; ; : cord-261417-4pf5nsw2 93 13 where where WRB cord-261417-4pf5nsw2 93 14 N N NNP cord-261417-4pf5nsw2 93 15 is be VBZ cord-261417-4pf5nsw2 93 16 the the DT cord-261417-4pf5nsw2 93 17 first first JJ cord-261417-4pf5nsw2 93 18 nt nt RB cord-261417-4pf5nsw2 93 19 of of IN cord-261417-4pf5nsw2 93 20 the the DT cord-261417-4pf5nsw2 93 21 nascent nascent JJ cord-261417-4pf5nsw2 93 22 RNA RNA NNP cord-261417-4pf5nsw2 93 23 ; ; : cord-261417-4pf5nsw2 93 24 Figure figure NN cord-261417-4pf5nsw2 93 25 2A 2a CD cord-261417-4pf5nsw2 93 26 ) ) -RRB- cord-261417-4pf5nsw2 93 27 in in IN cord-261417-4pf5nsw2 93 28 eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 93 29 mRNAs mRNAs NNPS cord-261417-4pf5nsw2 93 30 , , , cord-261417-4pf5nsw2 93 31 in in IN cord-261417-4pf5nsw2 93 32 which which WDT cord-261417-4pf5nsw2 93 33 7-methylguanosine 7-methylguanosine CD cord-261417-4pf5nsw2 93 34 ( ( -LRB- cord-261417-4pf5nsw2 93 35 m7 m7 NN cord-261417-4pf5nsw2 93 36 G G NNP cord-261417-4pf5nsw2 93 37 ) ) -RRB- cord-261417-4pf5nsw2 93 38 is be VBZ cord-261417-4pf5nsw2 93 39 linked link VBN cord-261417-4pf5nsw2 93 40 to to IN cord-261417-4pf5nsw2 93 41 the the DT cord-261417-4pf5nsw2 93 42 initiator initiator NN cord-261417-4pf5nsw2 93 43 nucleoside nucleoside NN cord-261417-4pf5nsw2 93 44 of of IN cord-261417-4pf5nsw2 93 45 mRNA mrna NN cord-261417-4pf5nsw2 93 46 through through IN cord-261417-4pf5nsw2 93 47 the the DT cord-261417-4pf5nsw2 93 48 5 5 CD cord-261417-4pf5nsw2 93 49 -5 -5 NNP cord-261417-4pf5nsw2 93 50 triphosphate triphosphate NN cord-261417-4pf5nsw2 93 51 bridge bridge NN cord-261417-4pf5nsw2 93 52 , , , cord-261417-4pf5nsw2 93 53 is be VBZ cord-261417-4pf5nsw2 93 54 mediated mediate VBN cord-261417-4pf5nsw2 93 55 by by IN cord-261417-4pf5nsw2 93 56 a a DT cord-261417-4pf5nsw2 93 57 series series NN cord-261417-4pf5nsw2 93 58 of of IN cord-261417-4pf5nsw2 93 59 enzymatic enzymatic JJ cord-261417-4pf5nsw2 93 60 steps step NNS cord-261417-4pf5nsw2 93 61 and and CC cord-261417-4pf5nsw2 93 62 is be VBZ cord-261417-4pf5nsw2 93 63 required require VBN cord-261417-4pf5nsw2 93 64 for for IN cord-261417-4pf5nsw2 93 65 the the DT cord-261417-4pf5nsw2 93 66 efficient efficient JJ cord-261417-4pf5nsw2 93 67 translation translation NN cord-261417-4pf5nsw2 93 68 and and CC cord-261417-4pf5nsw2 93 69 stability stability NN cord-261417-4pf5nsw2 93 70 of of IN cord-261417-4pf5nsw2 93 71 mRNAs mrnas CD cord-261417-4pf5nsw2 93 72 . . . cord-261417-4pf5nsw2 94 1 Eukaryotes eukaryote NNS cord-261417-4pf5nsw2 94 2 and and CC cord-261417-4pf5nsw2 94 3 some some DT cord-261417-4pf5nsw2 94 4 DNA dna NN cord-261417-4pf5nsw2 94 5 viruses virus NNS cord-261417-4pf5nsw2 94 6 ( ( -LRB- cord-261417-4pf5nsw2 94 7 e.g. e.g. RB cord-261417-4pf5nsw2 94 8 , , , cord-261417-4pf5nsw2 94 9 vaccinia vaccinia NN cord-261417-4pf5nsw2 94 10 virus virus NN cord-261417-4pf5nsw2 94 11 ) ) -RRB- cord-261417-4pf5nsw2 94 12 and and CC cord-261417-4pf5nsw2 94 13 dsRNA dsrna NN cord-261417-4pf5nsw2 94 14 viruses virus NNS cord-261417-4pf5nsw2 94 15 ( ( -LRB- cord-261417-4pf5nsw2 94 16 e.g. e.g. RB cord-261417-4pf5nsw2 94 17 , , , cord-261417-4pf5nsw2 94 18 reovirus reovirus NNP cord-261417-4pf5nsw2 94 19 ) ) -RRB- cord-261417-4pf5nsw2 95 1 obtain obtain VB cord-261417-4pf5nsw2 95 2 this this DT cord-261417-4pf5nsw2 95 3 cap cap NN cord-261417-4pf5nsw2 95 4 by by IN cord-261417-4pf5nsw2 95 5 processing process VBG cord-261417-4pf5nsw2 95 6 the the DT cord-261417-4pf5nsw2 95 7 5 5 CD cord-261417-4pf5nsw2 95 8 -triphosphate -triphosphate NN cord-261417-4pf5nsw2 95 9 end end NN cord-261417-4pf5nsw2 95 10 ( ( -LRB- cord-261417-4pf5nsw2 95 11 pppN- pppn- NN cord-261417-4pf5nsw2 95 12 ) ) -RRB- cord-261417-4pf5nsw2 95 13 of of IN cord-261417-4pf5nsw2 95 14 nascent nascent JJ cord-261417-4pf5nsw2 95 15 RNA RNA NNP cord-261417-4pf5nsw2 95 16 transcripts transcript NNS cord-261417-4pf5nsw2 95 17 into into IN cord-261417-4pf5nsw2 95 18 a a DT cord-261417-4pf5nsw2 95 19 diphosphate diphosphate NN cord-261417-4pf5nsw2 95 20 ( ( -LRB- cord-261417-4pf5nsw2 95 21 ppN- ppn- ADD cord-261417-4pf5nsw2 95 22 ) ) -RRB- cord-261417-4pf5nsw2 95 23 using use VBG cord-261417-4pf5nsw2 95 24 an an DT cord-261417-4pf5nsw2 95 25 RNA RNA NNP cord-261417-4pf5nsw2 95 26 5 5 CD cord-261417-4pf5nsw2 96 1 -triphosphatase -triphosphatase : cord-261417-4pf5nsw2 96 2 ( ( -LRB- cord-261417-4pf5nsw2 96 3 RTPase RTPase NFP cord-261417-4pf5nsw2 96 4 ) ) -RRB- cord-261417-4pf5nsw2 97 1 ( ( -LRB- cord-261417-4pf5nsw2 97 2 Figure figure NN cord-261417-4pf5nsw2 97 3 2B 2b CD cord-261417-4pf5nsw2 97 4 ) ) -RRB- cord-261417-4pf5nsw2 97 5 . . . cord-261417-4pf5nsw2 98 1 Subsequently subsequently RB cord-261417-4pf5nsw2 98 2 , , , cord-261417-4pf5nsw2 98 3 the the DT cord-261417-4pf5nsw2 98 4 guanosine guanosine NN cord-261417-4pf5nsw2 98 5 monophosphate monophosphate NN cord-261417-4pf5nsw2 98 6 ( ( -LRB- cord-261417-4pf5nsw2 98 7 GMP GMP NNP cord-261417-4pf5nsw2 98 8 ) ) -RRB- cord-261417-4pf5nsw2 98 9 moiety moiety VBZ cord-261417-4pf5nsw2 98 10 of of IN cord-261417-4pf5nsw2 98 11 a a DT cord-261417-4pf5nsw2 98 12 guanosine guanosine NN cord-261417-4pf5nsw2 98 13 triphosphate triphosphate NN cord-261417-4pf5nsw2 98 14 ( ( -LRB- cord-261417-4pf5nsw2 98 15 GTP GTP NNP cord-261417-4pf5nsw2 98 16 ) ) -RRB- cord-261417-4pf5nsw2 98 17 is be VBZ cord-261417-4pf5nsw2 98 18 transferred transfer VBN cord-261417-4pf5nsw2 98 19 to to IN cord-261417-4pf5nsw2 98 20 the the DT cord-261417-4pf5nsw2 98 21 5 5 CD cord-261417-4pf5nsw2 98 22 diphosphate diphosphate NN cord-261417-4pf5nsw2 98 23 by by IN cord-261417-4pf5nsw2 98 24 a a DT cord-261417-4pf5nsw2 98 25 GTP gtp NN cord-261417-4pf5nsw2 98 26 : : : cord-261417-4pf5nsw2 98 27 RNA rna NN cord-261417-4pf5nsw2 98 28 guanylyltransferase guanylyltransferase NN cord-261417-4pf5nsw2 98 29 ( ( -LRB- cord-261417-4pf5nsw2 98 30 GTase GTase NNP cord-261417-4pf5nsw2 98 31 ) ) -RRB- cord-261417-4pf5nsw2 98 32 to to TO cord-261417-4pf5nsw2 98 33 generate generate VB cord-261417-4pf5nsw2 98 34 the the DT cord-261417-4pf5nsw2 98 35 cap cap NN cord-261417-4pf5nsw2 98 36 core core NN cord-261417-4pf5nsw2 98 37 structure structure NN cord-261417-4pf5nsw2 98 38 ( ( -LRB- cord-261417-4pf5nsw2 98 39 Gp Gp NNP cord-261417-4pf5nsw2 98 40 - - HYPH cord-261417-4pf5nsw2 98 41 ppN- ppN- NNP cord-261417-4pf5nsw2 98 42 ) ) -RRB- cord-261417-4pf5nsw2 98 43 . . . cord-261417-4pf5nsw2 99 1 This this DT cord-261417-4pf5nsw2 99 2 core core NN cord-261417-4pf5nsw2 99 3 structure structure NN cord-261417-4pf5nsw2 99 4 is be VBZ cord-261417-4pf5nsw2 99 5 then then RB cord-261417-4pf5nsw2 99 6 methylated methylate VBN cord-261417-4pf5nsw2 99 7 at at IN cord-261417-4pf5nsw2 99 8 the the DT cord-261417-4pf5nsw2 99 9 guanine-7N guanine-7n NN cord-261417-4pf5nsw2 99 10 position position NN cord-261417-4pf5nsw2 99 11 by by IN cord-261417-4pf5nsw2 99 12 S s NN cord-261417-4pf5nsw2 99 13 - - HYPH cord-261417-4pf5nsw2 99 14 adenosyl adenosyl NN cord-261417-4pf5nsw2 99 15 - - HYPH cord-261417-4pf5nsw2 99 16 L l NN cord-261417-4pf5nsw2 99 17 - - HYPH cord-261417-4pf5nsw2 99 18 methionine methionine NN cord-261417-4pf5nsw2 99 19 ( ( -LRB- cord-261417-4pf5nsw2 99 20 AdoMet)-dependent AdoMet)-dependent NNP cord-261417-4pf5nsw2 99 21 cap cap NN cord-261417-4pf5nsw2 99 22 ( ( -LRB- cord-261417-4pf5nsw2 99 23 guanine guanine NN cord-261417-4pf5nsw2 99 24 - - HYPH cord-261417-4pf5nsw2 99 25 N7 n7 NN cord-261417-4pf5nsw2 99 26 ) ) -RRB- cord-261417-4pf5nsw2 100 1 methyltransferase methyltransferase NNP cord-261417-4pf5nsw2 100 2 ( ( -LRB- cord-261417-4pf5nsw2 100 3 MTase MTase NNP cord-261417-4pf5nsw2 100 4 ) ) -RRB- cord-261417-4pf5nsw2 101 1 to to TO cord-261417-4pf5nsw2 101 2 produce produce VB cord-261417-4pf5nsw2 101 3 the the DT cord-261417-4pf5nsw2 101 4 final final JJ cord-261417-4pf5nsw2 101 5 cap cap NN cord-261417-4pf5nsw2 101 6 structure structure NN cord-261417-4pf5nsw2 101 7 ( ( -LRB- cord-261417-4pf5nsw2 101 8 m7GpppN- m7GpppN- NNP cord-261417-4pf5nsw2 101 9 ) ) -RRB- cord-261417-4pf5nsw2 101 10 . . . cord-261417-4pf5nsw2 102 1 Higher high JJR cord-261417-4pf5nsw2 102 2 eukaryotes eukaryote NNS cord-261417-4pf5nsw2 102 3 and and CC cord-261417-4pf5nsw2 102 4 some some DT cord-261417-4pf5nsw2 102 5 viruses virus NNS cord-261417-4pf5nsw2 102 6 include include VBP cord-261417-4pf5nsw2 102 7 an an DT cord-261417-4pf5nsw2 102 8 additional additional JJ cord-261417-4pf5nsw2 102 9 methylation methylation NN cord-261417-4pf5nsw2 102 10 step step NN cord-261417-4pf5nsw2 102 11 in in IN cord-261417-4pf5nsw2 102 12 which which WDT cord-261417-4pf5nsw2 102 13 the the DT cord-261417-4pf5nsw2 102 14 2 2 CD cord-261417-4pf5nsw2 102 15 OH OH NNP cord-261417-4pf5nsw2 102 16 position position NN cord-261417-4pf5nsw2 102 17 of of IN cord-261417-4pf5nsw2 102 18 the the DT cord-261417-4pf5nsw2 102 19 penultimate penultimate JJ cord-261417-4pf5nsw2 102 20 ribose ribose NN cord-261417-4pf5nsw2 102 21 is be VBZ cord-261417-4pf5nsw2 102 22 methylated methylate VBN cord-261417-4pf5nsw2 102 23 by by IN cord-261417-4pf5nsw2 102 24 cap cap NN cord-261417-4pf5nsw2 102 25 ribose-2 ribose-2 NNP cord-261417-4pf5nsw2 102 26 -O -O : cord-261417-4pf5nsw2 102 27 - - : cord-261417-4pf5nsw2 102 28 MTase MTase NNP cord-261417-4pf5nsw2 102 29 ( ( -LRB- cord-261417-4pf5nsw2 102 30 m7GpppNm- m7GpppNm- NNP cord-261417-4pf5nsw2 102 31 ) ) -RRB- cord-261417-4pf5nsw2 102 32 . . . cord-261417-4pf5nsw2 103 1 However however RB cord-261417-4pf5nsw2 103 2 , , , cord-261417-4pf5nsw2 103 3 ssRNA ssrna NN cord-261417-4pf5nsw2 103 4 viruses virus NNS cord-261417-4pf5nsw2 103 5 ( ( -LRB- cord-261417-4pf5nsw2 103 6 e.g. e.g. RB cord-261417-4pf5nsw2 103 7 , , , cord-261417-4pf5nsw2 103 8 influenza influenza NN cord-261417-4pf5nsw2 103 9 , , , cord-261417-4pf5nsw2 103 10 Ebola Ebola NNP cord-261417-4pf5nsw2 103 11 , , , cord-261417-4pf5nsw2 103 12 measles measle NNS cord-261417-4pf5nsw2 103 13 ) ) -RRB- cord-261417-4pf5nsw2 103 14 do do VBP cord-261417-4pf5nsw2 103 15 not not RB cord-261417-4pf5nsw2 103 16 have have VB cord-261417-4pf5nsw2 103 17 a a DT cord-261417-4pf5nsw2 103 18 DNA dna NN cord-261417-4pf5nsw2 103 19 template template NN cord-261417-4pf5nsw2 103 20 and and CC cord-261417-4pf5nsw2 103 21 thus thus RB cord-261417-4pf5nsw2 103 22 can can MD cord-261417-4pf5nsw2 103 23 not not RB cord-261417-4pf5nsw2 103 24 rely rely VB cord-261417-4pf5nsw2 103 25 on on IN cord-261417-4pf5nsw2 103 26 the the DT cord-261417-4pf5nsw2 103 27 cellular cellular JJ cord-261417-4pf5nsw2 103 28 capping capping NN cord-261417-4pf5nsw2 103 29 enzymes enzyme NNS cord-261417-4pf5nsw2 103 30 . . . cord-261417-4pf5nsw2 104 1 For for IN cord-261417-4pf5nsw2 104 2 this this DT cord-261417-4pf5nsw2 104 3 reason reason NN cord-261417-4pf5nsw2 104 4 , , , cord-261417-4pf5nsw2 104 5 RNA RNA NNP cord-261417-4pf5nsw2 104 6 viruses virus NNS cord-261417-4pf5nsw2 104 7 have have VBP cord-261417-4pf5nsw2 104 8 evolved evolve VBN cord-261417-4pf5nsw2 104 9 capping cap VBG cord-261417-4pf5nsw2 104 10 mechanisms mechanism NNS cord-261417-4pf5nsw2 104 11 that that WDT cord-261417-4pf5nsw2 104 12 are be VBP cord-261417-4pf5nsw2 104 13 different different JJ cord-261417-4pf5nsw2 104 14 from from IN cord-261417-4pf5nsw2 104 15 capping cap VBG cord-261417-4pf5nsw2 104 16 during during IN cord-261417-4pf5nsw2 104 17 cellular cellular JJ cord-261417-4pf5nsw2 104 18 transcription transcription NN cord-261417-4pf5nsw2 104 19 . . . cord-261417-4pf5nsw2 105 1 Most Most JJS cord-261417-4pf5nsw2 105 2 + + CC cord-261417-4pf5nsw2 105 3 ssRNA ssrna NN cord-261417-4pf5nsw2 105 4 viruses virus NNS cord-261417-4pf5nsw2 105 5 ( ( -LRB- cord-261417-4pf5nsw2 105 6 e.g. e.g. RB cord-261417-4pf5nsw2 105 7 , , , cord-261417-4pf5nsw2 105 8 flaviviruses flavivirus NNS cord-261417-4pf5nsw2 105 9 and and CC cord-261417-4pf5nsw2 105 10 nidoviruses nidoviruse NNS cord-261417-4pf5nsw2 105 11 ) ) -RRB- cord-261417-4pf5nsw2 105 12 encode encode VB cord-261417-4pf5nsw2 105 13 capping cap VBG cord-261417-4pf5nsw2 105 14 enzymes enzyme NNS cord-261417-4pf5nsw2 105 15 that that WDT cord-261417-4pf5nsw2 105 16 selectively selectively RB cord-261417-4pf5nsw2 105 17 cap cap VBP cord-261417-4pf5nsw2 105 18 the the DT cord-261417-4pf5nsw2 105 19 newly newly RB cord-261417-4pf5nsw2 105 20 synthesized synthesize VBN cord-261417-4pf5nsw2 105 21 viral viral JJ cord-261417-4pf5nsw2 105 22 mRNAs mrnas CD cord-261417-4pf5nsw2 105 23 [ [ -LRB- cord-261417-4pf5nsw2 105 24 43 43 CD cord-261417-4pf5nsw2 105 25 ] ] -RRB- cord-261417-4pf5nsw2 105 26 [ [ -LRB- cord-261417-4pf5nsw2 105 27 44 44 CD cord-261417-4pf5nsw2 105 28 ] ] -RRB- cord-261417-4pf5nsw2 105 29 [ [ -LRB- cord-261417-4pf5nsw2 105 30 45 45 CD cord-261417-4pf5nsw2 105 31 ] ] -RRB- cord-261417-4pf5nsw2 105 32 . . . cord-261417-4pf5nsw2 106 1 For for IN cord-261417-4pf5nsw2 106 2 instance instance NN cord-261417-4pf5nsw2 106 3 , , , cord-261417-4pf5nsw2 106 4 the the DT cord-261417-4pf5nsw2 106 5 flavivirus flavivirus RB cord-261417-4pf5nsw2 106 6 - - HYPH cord-261417-4pf5nsw2 106 7 encoded encode VBN cord-261417-4pf5nsw2 106 8 nonstructural nonstructural JJ cord-261417-4pf5nsw2 106 9 protein protein NN cord-261417-4pf5nsw2 106 10 3 3 CD cord-261417-4pf5nsw2 106 11 ( ( -LRB- cord-261417-4pf5nsw2 106 12 NS3 ns3 RB cord-261417-4pf5nsw2 106 13 ) ) -RRB- cord-261417-4pf5nsw2 106 14 contains contain VBZ cord-261417-4pf5nsw2 106 15 a a DT cord-261417-4pf5nsw2 106 16 triphosphatase triphosphatase NN cord-261417-4pf5nsw2 106 17 that that WDT cord-261417-4pf5nsw2 106 18 releases release VBZ cord-261417-4pf5nsw2 106 19 the the DT cord-261417-4pf5nsw2 106 20 terminal terminal JJ cord-261417-4pf5nsw2 106 21 phosphate phosphate NN cord-261417-4pf5nsw2 106 22 from from IN cord-261417-4pf5nsw2 106 23 the the DT cord-261417-4pf5nsw2 106 24 5 5 CD cord-261417-4pf5nsw2 106 25 -triphosphate -triphosphate NN cord-261417-4pf5nsw2 106 26 end end NN cord-261417-4pf5nsw2 106 27 of of IN cord-261417-4pf5nsw2 106 28 nascent nascent JJ cord-261417-4pf5nsw2 106 29 + + SYM cord-261417-4pf5nsw2 106 30 stranded stranded JJ cord-261417-4pf5nsw2 106 31 RNA RNA NNP cord-261417-4pf5nsw2 106 32 , , , cord-261417-4pf5nsw2 106 33 forming form VBG cord-261417-4pf5nsw2 106 34 a a DT cord-261417-4pf5nsw2 106 35 diphosphorylated diphosphorylated JJ cord-261417-4pf5nsw2 106 36 ppN ppN NNP cord-261417-4pf5nsw2 106 37 - - HYPH cord-261417-4pf5nsw2 106 38 RNA RNA NNP cord-261417-4pf5nsw2 106 39 [ [ -LRB- cord-261417-4pf5nsw2 106 40 46 46 CD cord-261417-4pf5nsw2 106 41 ] ] -RRB- cord-261417-4pf5nsw2 106 42 . . . cord-261417-4pf5nsw2 107 1 Subsequently subsequently RB cord-261417-4pf5nsw2 107 2 , , , cord-261417-4pf5nsw2 107 3 a a DT cord-261417-4pf5nsw2 107 4 GMP GMP NNP cord-261417-4pf5nsw2 107 5 moiety moiety NN cord-261417-4pf5nsw2 107 6 from from IN cord-261417-4pf5nsw2 107 7 GTP GTP NNP cord-261417-4pf5nsw2 107 8 is be VBZ cord-261417-4pf5nsw2 107 9 transferred transfer VBN cord-261417-4pf5nsw2 107 10 to to IN cord-261417-4pf5nsw2 107 11 the the DT cord-261417-4pf5nsw2 107 12 5 5 CD cord-261417-4pf5nsw2 107 13 end end NN cord-261417-4pf5nsw2 107 14 of of IN cord-261417-4pf5nsw2 107 15 the the DT cord-261417-4pf5nsw2 107 16 ppN ppN NNP cord-261417-4pf5nsw2 107 17 - - : cord-261417-4pf5nsw2 107 18 RNA RNA NNP cord-261417-4pf5nsw2 107 19 through through IN cord-261417-4pf5nsw2 107 20 the the DT cord-261417-4pf5nsw2 107 21 GTase GTase NNP cord-261417-4pf5nsw2 107 22 activity activity NN cord-261417-4pf5nsw2 107 23 of of IN cord-261417-4pf5nsw2 107 24 the the DT cord-261417-4pf5nsw2 107 25 viral viral JJ cord-261417-4pf5nsw2 107 26 NS5 ns5 JJ cord-261417-4pf5nsw2 107 27 MTase MTase NNP cord-261417-4pf5nsw2 107 28 . . . cord-261417-4pf5nsw2 108 1 The the DT cord-261417-4pf5nsw2 108 2 GpppA GpppA NNP cord-261417-4pf5nsw2 108 3 - - HYPH cord-261417-4pf5nsw2 108 4 capped cap VBN cord-261417-4pf5nsw2 108 5 RNA RNA NNP cord-261417-4pf5nsw2 108 6 is be VBZ cord-261417-4pf5nsw2 108 7 further far RBR cord-261417-4pf5nsw2 108 8 methylated methylate VBN cord-261417-4pf5nsw2 108 9 by by IN cord-261417-4pf5nsw2 108 10 the the DT cord-261417-4pf5nsw2 108 11 NS5 ns5 JJ cord-261417-4pf5nsw2 108 12 MTase MTase NNP cord-261417-4pf5nsw2 108 13 to to TO cord-261417-4pf5nsw2 108 14 form form VB cord-261417-4pf5nsw2 108 15 the the DT cord-261417-4pf5nsw2 108 16 final final JJ cord-261417-4pf5nsw2 108 17 m(7)GpppA m(7)gpppa NN cord-261417-4pf5nsw2 108 18 - - HYPH cord-261417-4pf5nsw2 108 19 and and CC cord-261417-4pf5nsw2 108 20 m(7)GpppNm m(7)GpppNm NNP cord-261417-4pf5nsw2 108 21 - - HYPH cord-261417-4pf5nsw2 108 22 RNA RNA NNP cord-261417-4pf5nsw2 108 23 products product NNS cord-261417-4pf5nsw2 108 24 [ [ -LRB- cord-261417-4pf5nsw2 108 25 47 47 CD cord-261417-4pf5nsw2 108 26 , , , cord-261417-4pf5nsw2 108 27 48 48 CD cord-261417-4pf5nsw2 108 28 ] ] -RRB- cord-261417-4pf5nsw2 108 29 . . . cord-261417-4pf5nsw2 109 1 However however RB cord-261417-4pf5nsw2 109 2 , , , cord-261417-4pf5nsw2 109 3 both both CC cord-261417-4pf5nsw2 109 4 the the DT cord-261417-4pf5nsw2 109 5 process process NN cord-261417-4pf5nsw2 109 6 of of IN cord-261417-4pf5nsw2 109 7 discrimination discrimination NN cord-261417-4pf5nsw2 109 8 between between IN cord-261417-4pf5nsw2 109 9 −RNA −RNA NNP cord-261417-4pf5nsw2 109 10 and and CC cord-261417-4pf5nsw2 109 11 + + SYM cord-261417-4pf5nsw2 109 12 RNA RNA NNP cord-261417-4pf5nsw2 109 13 5 5 CD cord-261417-4pf5nsw2 110 1 -ends -end NNS cord-261417-4pf5nsw2 110 2 for for IN cord-261417-4pf5nsw2 110 3 capping capping NN cord-261417-4pf5nsw2 110 4 and and CC cord-261417-4pf5nsw2 110 5 the the DT cord-261417-4pf5nsw2 110 6 precise precise JJ cord-261417-4pf5nsw2 110 7 timing timing NN cord-261417-4pf5nsw2 110 8 of of IN cord-261417-4pf5nsw2 110 9 the the DT cord-261417-4pf5nsw2 110 10 capping capping NN cord-261417-4pf5nsw2 110 11 process process NN cord-261417-4pf5nsw2 110 12 remain remain VBP cord-261417-4pf5nsw2 110 13 largely largely RB cord-261417-4pf5nsw2 110 14 undefined undefined JJ cord-261417-4pf5nsw2 110 15 [ [ -LRB- cord-261417-4pf5nsw2 110 16 49 49 CD cord-261417-4pf5nsw2 110 17 ] ] -RRB- cord-261417-4pf5nsw2 110 18 . . . cord-261417-4pf5nsw2 111 1 On on IN cord-261417-4pf5nsw2 111 2 the the DT cord-261417-4pf5nsw2 111 3 other other JJ cord-261417-4pf5nsw2 111 4 hand hand NN cord-261417-4pf5nsw2 111 5 , , , cord-261417-4pf5nsw2 111 6 unsegmented unsegmente VBD cord-261417-4pf5nsw2 111 7 −ssRNA −ssRNA NNS cord-261417-4pf5nsw2 111 8 viruses virus NNS cord-261417-4pf5nsw2 111 9 ( ( -LRB- cord-261417-4pf5nsw2 111 10 including include VBG cord-261417-4pf5nsw2 111 11 rabies rabie NNS cord-261417-4pf5nsw2 111 12 , , , cord-261417-4pf5nsw2 111 13 measles measle NNS cord-261417-4pf5nsw2 111 14 , , , cord-261417-4pf5nsw2 111 15 and and CC cord-261417-4pf5nsw2 111 16 Ebola Ebola NNP cord-261417-4pf5nsw2 111 17 ) ) -RRB- cord-261417-4pf5nsw2 111 18 carry carry VBP cord-261417-4pf5nsw2 111 19 an an DT cord-261417-4pf5nsw2 111 20 RdRp RdRp NNP cord-261417-4pf5nsw2 111 21 termed term VBN cord-261417-4pf5nsw2 111 22 " " `` cord-261417-4pf5nsw2 111 23 L L NNP cord-261417-4pf5nsw2 111 24 " " '' cord-261417-4pf5nsw2 111 25 and and CC cord-261417-4pf5nsw2 111 26 a a DT cord-261417-4pf5nsw2 111 27 phosphoprotein phosphoprotein NN cord-261417-4pf5nsw2 111 28 " " `` cord-261417-4pf5nsw2 111 29 P p NN cord-261417-4pf5nsw2 111 30 " " '' cord-261417-4pf5nsw2 111 31 , , , cord-261417-4pf5nsw2 111 32 which which WDT cord-261417-4pf5nsw2 111 33 share share VBP cord-261417-4pf5nsw2 111 34 extensive extensive JJ cord-261417-4pf5nsw2 111 35 amino amino NN cord-261417-4pf5nsw2 111 36 acid acid NN cord-261417-4pf5nsw2 111 37 sequence sequence NN cord-261417-4pf5nsw2 111 38 similarity similarity NN cord-261417-4pf5nsw2 111 39 among among IN cord-261417-4pf5nsw2 111 40 all all PDT cord-261417-4pf5nsw2 111 41 these these DT cord-261417-4pf5nsw2 111 42 viruses virus NNS cord-261417-4pf5nsw2 111 43 [ [ -LRB- cord-261417-4pf5nsw2 111 44 50 50 CD cord-261417-4pf5nsw2 111 45 ] ] -RRB- cord-261417-4pf5nsw2 111 46 . . . cord-261417-4pf5nsw2 112 1 P p NN cord-261417-4pf5nsw2 112 2 is be VBZ cord-261417-4pf5nsw2 112 3 an an DT cord-261417-4pf5nsw2 112 4 essential essential JJ cord-261417-4pf5nsw2 112 5 co co NN cord-261417-4pf5nsw2 112 6 - - NN cord-261417-4pf5nsw2 112 7 factor factor NN cord-261417-4pf5nsw2 112 8 that that WDT cord-261417-4pf5nsw2 112 9 targets target VBZ cord-261417-4pf5nsw2 112 10 the the DT cord-261417-4pf5nsw2 112 11 L L NNP cord-261417-4pf5nsw2 112 12 polymerase polymerase NN cord-261417-4pf5nsw2 112 13 to to IN cord-261417-4pf5nsw2 112 14 the the DT cord-261417-4pf5nsw2 112 15 vRNA vRNA JJS cord-261417-4pf5nsw2 112 16 [ [ -LRB- cord-261417-4pf5nsw2 112 17 51 51 CD cord-261417-4pf5nsw2 112 18 ] ] -RRB- cord-261417-4pf5nsw2 112 19 [ [ -LRB- cord-261417-4pf5nsw2 112 20 52 52 CD cord-261417-4pf5nsw2 112 21 ] ] -RRB- cord-261417-4pf5nsw2 112 22 [ [ -LRB- cord-261417-4pf5nsw2 112 23 53 53 CD cord-261417-4pf5nsw2 112 24 ] ] -RRB- cord-261417-4pf5nsw2 112 25 . . . cord-261417-4pf5nsw2 113 1 Here here RB cord-261417-4pf5nsw2 113 2 , , , cord-261417-4pf5nsw2 113 3 the the DT cord-261417-4pf5nsw2 113 4 L l NN cord-261417-4pf5nsw2 113 5 polymerase polymerase NN cord-261417-4pf5nsw2 113 6 covalently covalently RB cord-261417-4pf5nsw2 113 7 links link VBZ cord-261417-4pf5nsw2 113 8 with with IN cord-261417-4pf5nsw2 113 9 the the DT cord-261417-4pf5nsw2 113 10 5 5 CD cord-261417-4pf5nsw2 113 11 -monophosphorylated -monophosphorylated JJ cord-261417-4pf5nsw2 113 12 viral viral JJ cord-261417-4pf5nsw2 113 13 mRNA mrna NN cord-261417-4pf5nsw2 113 14 - - HYPH cord-261417-4pf5nsw2 113 15 start start NN cord-261417-4pf5nsw2 113 16 sequence sequence NN cord-261417-4pf5nsw2 113 17 to to TO cord-261417-4pf5nsw2 113 18 form form VB cord-261417-4pf5nsw2 113 19 an an DT cord-261417-4pf5nsw2 113 20 intermediate intermediate JJ cord-261417-4pf5nsw2 113 21 complex complex NN cord-261417-4pf5nsw2 113 22 ( ( -LRB- cord-261417-4pf5nsw2 113 23 Figure figure NN cord-261417-4pf5nsw2 113 24 2C 2c NN cord-261417-4pf5nsw2 113 25 ) ) -RRB- cord-261417-4pf5nsw2 113 26 [ [ -LRB- cord-261417-4pf5nsw2 113 27 54 54 CD cord-261417-4pf5nsw2 113 28 ] ] -RRB- cord-261417-4pf5nsw2 113 29 . . . cord-261417-4pf5nsw2 114 1 Subsequently subsequently RB cord-261417-4pf5nsw2 114 2 , , , cord-261417-4pf5nsw2 114 3 the the DT cord-261417-4pf5nsw2 114 4 RNA RNA NNP cord-261417-4pf5nsw2 114 5 : : : cord-261417-4pf5nsw2 114 6 GDP GDP NNP cord-261417-4pf5nsw2 114 7 polyribonucleotidyltransferase polyribonucleotidyltransferase NN cord-261417-4pf5nsw2 114 8 activity activity NN cord-261417-4pf5nsw2 114 9 of of IN cord-261417-4pf5nsw2 114 10 the the DT cord-261417-4pf5nsw2 114 11 L l NN cord-261417-4pf5nsw2 114 12 polymerase polymerase NN cord-261417-4pf5nsw2 114 13 transfers transfer VBZ cord-261417-4pf5nsw2 114 14 the the DT cord-261417-4pf5nsw2 114 15 GDP GDP NNP cord-261417-4pf5nsw2 114 16 moiety moiety NN cord-261417-4pf5nsw2 114 17 of of IN cord-261417-4pf5nsw2 114 18 GTP GTP NNP cord-261417-4pf5nsw2 114 19 to to IN cord-261417-4pf5nsw2 114 20 the the DT cord-261417-4pf5nsw2 114 21 monophosphorylated monophosphorylated NNP cord-261417-4pf5nsw2 114 22 viral viral JJ cord-261417-4pf5nsw2 114 23 mRNA mRNA NNP cord-261417-4pf5nsw2 114 24 forming form VBG cord-261417-4pf5nsw2 114 25 the the DT cord-261417-4pf5nsw2 114 26 viral viral JJ cord-261417-4pf5nsw2 114 27 mRNA mRNA NNP cord-261417-4pf5nsw2 114 28 cap cap NN cord-261417-4pf5nsw2 114 29 . . . cord-261417-4pf5nsw2 115 1 Thus thus RB cord-261417-4pf5nsw2 115 2 , , , cord-261417-4pf5nsw2 115 3 in in IN cord-261417-4pf5nsw2 115 4 contrast contrast NN cord-261417-4pf5nsw2 115 5 to to IN cord-261417-4pf5nsw2 115 6 GTases gtase NNS cord-261417-4pf5nsw2 115 7 which which WDT cord-261417-4pf5nsw2 115 8 transfer transfer VBP cord-261417-4pf5nsw2 115 9 a a DT cord-261417-4pf5nsw2 115 10 monophosphate monophosphate NN cord-261417-4pf5nsw2 115 11 to to IN cord-261417-4pf5nsw2 115 12 the the DT cord-261417-4pf5nsw2 115 13 5 5 CD cord-261417-4pf5nsw2 115 14 diphosphate diphosphate NN cord-261417-4pf5nsw2 115 15 end end NN cord-261417-4pf5nsw2 115 16 of of IN cord-261417-4pf5nsw2 115 17 RNA RNA NNP cord-261417-4pf5nsw2 115 18 , , , cord-261417-4pf5nsw2 115 19 the the DT cord-261417-4pf5nsw2 115 20 L L NNP cord-261417-4pf5nsw2 115 21 polymerase polymerase NN cord-261417-4pf5nsw2 115 22 - - HYPH cord-261417-4pf5nsw2 115 23 mediated mediate VBN cord-261417-4pf5nsw2 115 24 capping cap VBG cord-261417-4pf5nsw2 115 25 reaction reaction NN cord-261417-4pf5nsw2 115 26 transfers transfer VBZ cord-261417-4pf5nsw2 115 27 a a DT cord-261417-4pf5nsw2 115 28 diphosphate diphosphate NN cord-261417-4pf5nsw2 115 29 to to IN cord-261417-4pf5nsw2 115 30 the the DT cord-261417-4pf5nsw2 115 31 5 5 CD cord-261417-4pf5nsw2 115 32 monophosphate monophosphate NN cord-261417-4pf5nsw2 115 33 end end NN cord-261417-4pf5nsw2 115 34 of of IN cord-261417-4pf5nsw2 115 35 RNA RNA NNP cord-261417-4pf5nsw2 115 36 . . . cord-261417-4pf5nsw2 116 1 Another another DT cord-261417-4pf5nsw2 116 2 solution solution NN cord-261417-4pf5nsw2 116 3 to to IN cord-261417-4pf5nsw2 116 4 the the DT cord-261417-4pf5nsw2 116 5 capping cap VBG cord-261417-4pf5nsw2 116 6 problem problem NN cord-261417-4pf5nsw2 116 7 of of IN cord-261417-4pf5nsw2 116 8 the the DT cord-261417-4pf5nsw2 116 9 negative negative JJ cord-261417-4pf5nsw2 116 10 - - HYPH cord-261417-4pf5nsw2 116 11 sense sense NN cord-261417-4pf5nsw2 116 12 RNA RNA NNP cord-261417-4pf5nsw2 116 13 viruses virus NNS cord-261417-4pf5nsw2 116 14 comes come VBZ cord-261417-4pf5nsw2 116 15 from from IN cord-261417-4pf5nsw2 116 16 the the DT cord-261417-4pf5nsw2 116 17 influenza influenza NN cord-261417-4pf5nsw2 116 18 virus virus NN cord-261417-4pf5nsw2 116 19 in in IN cord-261417-4pf5nsw2 116 20 the the DT cord-261417-4pf5nsw2 116 21 form form NN cord-261417-4pf5nsw2 116 22 of of IN cord-261417-4pf5nsw2 116 23 " " `` cord-261417-4pf5nsw2 116 24 cap cap NN cord-261417-4pf5nsw2 116 25 - - HYPH cord-261417-4pf5nsw2 116 26 snatching snatching NN cord-261417-4pf5nsw2 116 27 " " '' cord-261417-4pf5nsw2 116 28 from from IN cord-261417-4pf5nsw2 116 29 nascent nascent JJ cord-261417-4pf5nsw2 116 30 host host NN cord-261417-4pf5nsw2 116 31 pre pre VB cord-261417-4pf5nsw2 116 32 - - NNS cord-261417-4pf5nsw2 116 33 mRNAs mrnas JJ cord-261417-4pf5nsw2 116 34 [ [ -LRB- cord-261417-4pf5nsw2 116 35 55 55 CD cord-261417-4pf5nsw2 116 36 ] ] -RRB- cord-261417-4pf5nsw2 116 37 . . . cord-261417-4pf5nsw2 117 1 To to TO cord-261417-4pf5nsw2 117 2 synthesize synthesize VB cord-261417-4pf5nsw2 117 3 viral viral JJ cord-261417-4pf5nsw2 117 4 mRNA mrna NN cord-261417-4pf5nsw2 117 5 and and CC cord-261417-4pf5nsw2 118 1 vRNA vrna RB cord-261417-4pf5nsw2 118 2 from from IN cord-261417-4pf5nsw2 118 3 each each DT cord-261417-4pf5nsw2 118 4 of of IN cord-261417-4pf5nsw2 118 5 the the DT cord-261417-4pf5nsw2 118 6 eight eight CD cord-261417-4pf5nsw2 118 7 single single JJ cord-261417-4pf5nsw2 118 8 - - HYPH cord-261417-4pf5nsw2 118 9 stranded strand VBN cord-261417-4pf5nsw2 118 10 viral viral JJ cord-261417-4pf5nsw2 118 11 RNA RNA NNP cord-261417-4pf5nsw2 118 12 segments segment NNS cord-261417-4pf5nsw2 118 13 , , , cord-261417-4pf5nsw2 118 14 influenza influenza NN cord-261417-4pf5nsw2 118 15 uses use VBZ cord-261417-4pf5nsw2 118 16 a a DT cord-261417-4pf5nsw2 118 17 virally virally RB cord-261417-4pf5nsw2 118 18 encoded encode VBN cord-261417-4pf5nsw2 118 19 heterotrimeric heterotrimeric NN cord-261417-4pf5nsw2 118 20 RdRp RdRp NNP cord-261417-4pf5nsw2 118 21 called call VBN cord-261417-4pf5nsw2 118 22 FluPol FluPol NNP cord-261417-4pf5nsw2 118 23 ( ( -LRB- cord-261417-4pf5nsw2 118 24 Figure Figure NNP cord-261417-4pf5nsw2 118 25 2D 2d NN cord-261417-4pf5nsw2 118 26 ) ) -RRB- cord-261417-4pf5nsw2 118 27 . . . cord-261417-4pf5nsw2 119 1 FluPol FluPol NNP cord-261417-4pf5nsw2 119 2 consists consist VBZ cord-261417-4pf5nsw2 119 3 of of IN cord-261417-4pf5nsw2 119 4 three three CD cord-261417-4pf5nsw2 119 5 virally virally RB cord-261417-4pf5nsw2 119 6 encoded encode VBN cord-261417-4pf5nsw2 119 7 subunits subunit NNS cord-261417-4pf5nsw2 119 8 : : : cord-261417-4pf5nsw2 119 9 polymerase polymerase VB cord-261417-4pf5nsw2 119 10 basic basic JJ cord-261417-4pf5nsw2 119 11 1 1 CD cord-261417-4pf5nsw2 119 12 ( ( -LRB- cord-261417-4pf5nsw2 119 13 PB1 PB1 NNP cord-261417-4pf5nsw2 119 14 ) ) -RRB- cord-261417-4pf5nsw2 119 15 , , , cord-261417-4pf5nsw2 119 16 PB2 PB2 NNP cord-261417-4pf5nsw2 119 17 , , , cord-261417-4pf5nsw2 119 18 and and CC cord-261417-4pf5nsw2 119 19 polymerase polymerase VB cord-261417-4pf5nsw2 119 20 acidic acidic JJ cord-261417-4pf5nsw2 119 21 ( ( -LRB- cord-261417-4pf5nsw2 119 22 PA PA NNP cord-261417-4pf5nsw2 119 23 ) ) -RRB- cord-261417-4pf5nsw2 119 24 arranged arrange VBD cord-261417-4pf5nsw2 119 25 in in IN cord-261417-4pf5nsw2 119 26 a a DT cord-261417-4pf5nsw2 119 27 globular globular JJ cord-261417-4pf5nsw2 119 28 structure structure NN cord-261417-4pf5nsw2 119 29 [ [ -LRB- cord-261417-4pf5nsw2 119 30 56 56 CD cord-261417-4pf5nsw2 119 31 ] ] -RRB- cord-261417-4pf5nsw2 119 32 [ [ -LRB- cord-261417-4pf5nsw2 119 33 57 57 CD cord-261417-4pf5nsw2 119 34 ] ] -RRB- cord-261417-4pf5nsw2 119 35 [ [ -LRB- cord-261417-4pf5nsw2 119 36 58 58 CD cord-261417-4pf5nsw2 119 37 ] ] -RRB- cord-261417-4pf5nsw2 119 38 . . . cord-261417-4pf5nsw2 120 1 Each each DT cord-261417-4pf5nsw2 120 2 genome genome NN cord-261417-4pf5nsw2 120 3 segment segment NN cord-261417-4pf5nsw2 120 4 is be VBZ cord-261417-4pf5nsw2 120 5 circularized circularize VBN cord-261417-4pf5nsw2 120 6 by by IN cord-261417-4pf5nsw2 120 7 the the DT cord-261417-4pf5nsw2 120 8 base base NN cord-261417-4pf5nsw2 120 9 - - HYPH cord-261417-4pf5nsw2 120 10 pairing pairing NN cord-261417-4pf5nsw2 120 11 of of IN cord-261417-4pf5nsw2 120 12 the the DT cord-261417-4pf5nsw2 120 13 near near JJ cord-261417-4pf5nsw2 120 14 complementary complementary JJ cord-261417-4pf5nsw2 120 15 5 5 CD cord-261417-4pf5nsw2 120 16 and and CC cord-261417-4pf5nsw2 120 17 3 3 CD cord-261417-4pf5nsw2 120 18 ends end NNS cord-261417-4pf5nsw2 120 19 , , , cord-261417-4pf5nsw2 120 20 and and CC cord-261417-4pf5nsw2 120 21 individually individually RB cord-261417-4pf5nsw2 120 22 packaged package VBN cord-261417-4pf5nsw2 120 23 into into IN cord-261417-4pf5nsw2 120 24 viral viral JJ cord-261417-4pf5nsw2 120 25 ribonucleoprotein ribonucleoprotein NN cord-261417-4pf5nsw2 120 26 particles particle NNS cord-261417-4pf5nsw2 120 27 ( ( -LRB- cord-261417-4pf5nsw2 120 28 vRNPs vrnps RB cord-261417-4pf5nsw2 120 29 ) ) -RRB- cord-261417-4pf5nsw2 120 30 together together RB cord-261417-4pf5nsw2 120 31 with with IN cord-261417-4pf5nsw2 120 32 one one CD cord-261417-4pf5nsw2 120 33 copy copy NN cord-261417-4pf5nsw2 120 34 of of IN cord-261417-4pf5nsw2 120 35 FluPol FluPol NNP cord-261417-4pf5nsw2 120 36 . . . cord-261417-4pf5nsw2 121 1 FluPol FluPol NNP cord-261417-4pf5nsw2 121 2 is be VBZ cord-261417-4pf5nsw2 121 3 bound bind VBN cord-261417-4pf5nsw2 121 4 to to IN cord-261417-4pf5nsw2 121 5 the the DT cord-261417-4pf5nsw2 121 6 duplex duplex NN cord-261417-4pf5nsw2 121 7 at at IN cord-261417-4pf5nsw2 121 8 the the DT cord-261417-4pf5nsw2 121 9 point point NN cord-261417-4pf5nsw2 121 10 of of IN cord-261417-4pf5nsw2 121 11 circularization circularization NN cord-261417-4pf5nsw2 121 12 , , , cord-261417-4pf5nsw2 121 13 tightly tightly RB cord-261417-4pf5nsw2 121 14 docked dock VBN cord-261417-4pf5nsw2 121 15 into into IN cord-261417-4pf5nsw2 121 16 the the DT cord-261417-4pf5nsw2 121 17 5 5 CD cord-261417-4pf5nsw2 121 18 end end NN cord-261417-4pf5nsw2 121 19 of of IN cord-261417-4pf5nsw2 121 20 the the DT cord-261417-4pf5nsw2 121 21 vRNA vRNA JJS cord-261417-4pf5nsw2 121 22 by by IN cord-261417-4pf5nsw2 121 23 a a DT cord-261417-4pf5nsw2 121 24 pocket pocket NN cord-261417-4pf5nsw2 121 25 formed form VBN cord-261417-4pf5nsw2 121 26 between between IN cord-261417-4pf5nsw2 121 27 the the DT cord-261417-4pf5nsw2 121 28 PA PA NNP cord-261417-4pf5nsw2 121 29 and and CC cord-261417-4pf5nsw2 121 30 PB1 PB1 NNP cord-261417-4pf5nsw2 121 31 subunits subunit NNS cord-261417-4pf5nsw2 121 32 , , , cord-261417-4pf5nsw2 121 33 creating create VBG cord-261417-4pf5nsw2 121 34 an an DT cord-261417-4pf5nsw2 121 35 intramolecular intramolecular JJ cord-261417-4pf5nsw2 121 36 stem stem NN cord-261417-4pf5nsw2 121 37 - - HYPH cord-261417-4pf5nsw2 121 38 loop loop NN cord-261417-4pf5nsw2 121 39 ( ( -LRB- cord-261417-4pf5nsw2 121 40 ' ' `` cord-261417-4pf5nsw2 121 41 hook hook NN cord-261417-4pf5nsw2 121 42 ' ' '' cord-261417-4pf5nsw2 121 43 ; ; : cord-261417-4pf5nsw2 121 44 Figure figure NN cord-261417-4pf5nsw2 121 45 2A 2a CD cord-261417-4pf5nsw2 121 46 ) ) -RRB- cord-261417-4pf5nsw2 122 1 [ [ -LRB- cord-261417-4pf5nsw2 122 2 56 56 CD cord-261417-4pf5nsw2 122 3 , , , cord-261417-4pf5nsw2 122 4 57 57 CD cord-261417-4pf5nsw2 122 5 ] ] -RRB- cord-261417-4pf5nsw2 122 6 . . . cord-261417-4pf5nsw2 123 1 The the DT cord-261417-4pf5nsw2 123 2 3 3 CD cord-261417-4pf5nsw2 123 3 segment segment NN cord-261417-4pf5nsw2 123 4 of of IN cord-261417-4pf5nsw2 123 5 the the DT cord-261417-4pf5nsw2 123 6 negative negative JJ cord-261417-4pf5nsw2 123 7 - - HYPH cord-261417-4pf5nsw2 123 8 sense sense NN cord-261417-4pf5nsw2 123 9 vRNA vrna NN cord-261417-4pf5nsw2 123 10 enters enter VBZ cord-261417-4pf5nsw2 123 11 the the DT cord-261417-4pf5nsw2 123 12 active active JJ cord-261417-4pf5nsw2 123 13 - - HYPH cord-261417-4pf5nsw2 123 14 site site NN cord-261417-4pf5nsw2 123 15 cavity cavity NN cord-261417-4pf5nsw2 123 16 of of IN cord-261417-4pf5nsw2 123 17 FluPol FluPol NNP cord-261417-4pf5nsw2 123 18 , , , cord-261417-4pf5nsw2 123 19 where where WRB cord-261417-4pf5nsw2 123 20 it -PRON- PRP cord-261417-4pf5nsw2 123 21 serves serve VBZ cord-261417-4pf5nsw2 123 22 as as IN cord-261417-4pf5nsw2 123 23 a a DT cord-261417-4pf5nsw2 123 24 template template NN cord-261417-4pf5nsw2 123 25 ( ( -LRB- cord-261417-4pf5nsw2 123 26 Figure figure NN cord-261417-4pf5nsw2 123 27 2E 2e NN cord-261417-4pf5nsw2 123 28 ) ) -RRB- cord-261417-4pf5nsw2 124 1 [ [ -LRB- cord-261417-4pf5nsw2 124 2 59 59 CD cord-261417-4pf5nsw2 124 3 , , , cord-261417-4pf5nsw2 124 4 60 60 CD cord-261417-4pf5nsw2 124 5 ] ] -RRB- cord-261417-4pf5nsw2 124 6 . . . cord-261417-4pf5nsw2 125 1 After after IN cord-261417-4pf5nsw2 125 2 entry entry NN cord-261417-4pf5nsw2 125 3 into into IN cord-261417-4pf5nsw2 125 4 the the DT cord-261417-4pf5nsw2 125 5 cell cell NN cord-261417-4pf5nsw2 125 6 , , , cord-261417-4pf5nsw2 125 7 the the DT cord-261417-4pf5nsw2 125 8 vRNPs vrnp NNS cord-261417-4pf5nsw2 125 9 are be VBP cord-261417-4pf5nsw2 125 10 released release VBN cord-261417-4pf5nsw2 125 11 and and CC cord-261417-4pf5nsw2 125 12 transported transport VBN cord-261417-4pf5nsw2 125 13 into into IN cord-261417-4pf5nsw2 125 14 the the DT cord-261417-4pf5nsw2 125 15 nucleus nucleus NN cord-261417-4pf5nsw2 125 16 . . . cord-261417-4pf5nsw2 126 1 After after IN cord-261417-4pf5nsw2 126 2 arrival arrival NN cord-261417-4pf5nsw2 126 3 in in IN cord-261417-4pf5nsw2 126 4 the the DT cord-261417-4pf5nsw2 126 5 nucleus nucleus NN cord-261417-4pf5nsw2 126 6 , , , cord-261417-4pf5nsw2 126 7 the the DT cord-261417-4pf5nsw2 126 8 C C NNP cord-261417-4pf5nsw2 126 9 - - HYPH cord-261417-4pf5nsw2 126 10 terminal terminal NN cord-261417-4pf5nsw2 126 11 domain domain NN cord-261417-4pf5nsw2 126 12 of of IN cord-261417-4pf5nsw2 126 13 the the DT cord-261417-4pf5nsw2 126 14 FluPol FluPol NNP cord-261417-4pf5nsw2 126 15 PA PA NNP cord-261417-4pf5nsw2 126 16 subunit subunit NN cord-261417-4pf5nsw2 126 17 will will MD cord-261417-4pf5nsw2 126 18 specifically specifically RB cord-261417-4pf5nsw2 126 19 target target VB cord-261417-4pf5nsw2 126 20 and and CC cord-261417-4pf5nsw2 126 21 bind bind VB cord-261417-4pf5nsw2 126 22 the the DT cord-261417-4pf5nsw2 126 23 phosphorylated phosphorylated JJ cord-261417-4pf5nsw2 126 24 Ser5 Ser5 NNPS cord-261417-4pf5nsw2 126 25 of of IN cord-261417-4pf5nsw2 126 26 actively actively RB cord-261417-4pf5nsw2 126 27 transcribing transcribe VBG cord-261417-4pf5nsw2 126 28 RNAPII RNAPII NNP cord-261417-4pf5nsw2 126 29 CTD CTD NNP cord-261417-4pf5nsw2 126 30 [ [ -LRB- cord-261417-4pf5nsw2 126 31 61 61 CD cord-261417-4pf5nsw2 126 32 ] ] -RRB- cord-261417-4pf5nsw2 127 1 ( ( -LRB- cord-261417-4pf5nsw2 127 2 Figure figure NN cord-261417-4pf5nsw2 127 3 2E 2e NN cord-261417-4pf5nsw2 127 4 ) ) -RRB- cord-261417-4pf5nsw2 127 5 . . . cord-261417-4pf5nsw2 128 1 Subsequently subsequently RB cord-261417-4pf5nsw2 128 2 , , , cord-261417-4pf5nsw2 128 3 the the DT cord-261417-4pf5nsw2 128 4 PB2 PB2 NNP cord-261417-4pf5nsw2 128 5 cap cap NN cord-261417-4pf5nsw2 128 6 - - HYPH cord-261417-4pf5nsw2 128 7 binding bind VBG cord-261417-4pf5nsw2 128 8 domain domain NN cord-261417-4pf5nsw2 128 9 associates associate NNS cord-261417-4pf5nsw2 128 10 with with IN cord-261417-4pf5nsw2 128 11 the the DT cord-261417-4pf5nsw2 128 12 5 5 CD cord-261417-4pf5nsw2 128 13 end end NN cord-261417-4pf5nsw2 128 14 of of IN cord-261417-4pf5nsw2 128 15 the the DT cord-261417-4pf5nsw2 128 16 cellular cellular JJ cord-261417-4pf5nsw2 128 17 mRNA mrna NN cord-261417-4pf5nsw2 128 18 [ [ -LRB- cord-261417-4pf5nsw2 128 19 60 60 CD cord-261417-4pf5nsw2 128 20 ] ] -RRB- cord-261417-4pf5nsw2 128 21 . . . cord-261417-4pf5nsw2 129 1 The the DT cord-261417-4pf5nsw2 129 2 PA PA NNP cord-261417-4pf5nsw2 129 3 endonuclease endonuclease NN cord-261417-4pf5nsw2 129 4 domain domain NN cord-261417-4pf5nsw2 129 5 next next RB cord-261417-4pf5nsw2 129 6 cleaves cleave VBZ cord-261417-4pf5nsw2 129 7 the the DT cord-261417-4pf5nsw2 129 8 mRNA mrna NN cord-261417-4pf5nsw2 129 9 . . . cord-261417-4pf5nsw2 130 1 This this DT cord-261417-4pf5nsw2 130 2 creates create VBZ cord-261417-4pf5nsw2 130 3 a a DT cord-261417-4pf5nsw2 130 4 capped cap VBN cord-261417-4pf5nsw2 130 5 11 11 CD cord-261417-4pf5nsw2 130 6 - - SYM cord-261417-4pf5nsw2 130 7 12 12 CD cord-261417-4pf5nsw2 130 8 nt nt NNP cord-261417-4pf5nsw2 130 9 small small JJ cord-261417-4pf5nsw2 130 10 RNA RNA NNP cord-261417-4pf5nsw2 130 11 primer primer NN cord-261417-4pf5nsw2 130 12 that that WDT cord-261417-4pf5nsw2 130 13 is be VBZ cord-261417-4pf5nsw2 130 14 loaded load VBN cord-261417-4pf5nsw2 130 15 into into IN cord-261417-4pf5nsw2 130 16 the the DT cord-261417-4pf5nsw2 130 17 active active JJ cord-261417-4pf5nsw2 130 18 site site NN cord-261417-4pf5nsw2 130 19 of of IN cord-261417-4pf5nsw2 130 20 FluPol FluPol NNP cord-261417-4pf5nsw2 130 21 [ [ -LRB- cord-261417-4pf5nsw2 130 22 62 62 CD cord-261417-4pf5nsw2 130 23 ] ] -RRB- cord-261417-4pf5nsw2 131 1 [ [ -LRB- cord-261417-4pf5nsw2 131 2 63 63 CD cord-261417-4pf5nsw2 131 3 ] ] -RRB- cord-261417-4pf5nsw2 132 1 [ [ -LRB- cord-261417-4pf5nsw2 132 2 64 64 CD cord-261417-4pf5nsw2 132 3 ] ] -RRB- cord-261417-4pf5nsw2 133 1 ( ( -LRB- cord-261417-4pf5nsw2 133 2 Figure figure NN cord-261417-4pf5nsw2 133 3 2E 2e NN cord-261417-4pf5nsw2 133 4 ) ) -RRB- cord-261417-4pf5nsw2 133 5 . . . cord-261417-4pf5nsw2 134 1 Processive Processive NNP cord-261417-4pf5nsw2 134 2 Rd Rd NNP cord-261417-4pf5nsw2 134 3 - - HYPH cord-261417-4pf5nsw2 134 4 mRNA mRNA NNP cord-261417-4pf5nsw2 134 5 synthesis synthesis NN cord-261417-4pf5nsw2 134 6 is be VBZ cord-261417-4pf5nsw2 134 7 initiated initiate VBN cord-261417-4pf5nsw2 134 8 by by IN cord-261417-4pf5nsw2 134 9 the the DT cord-261417-4pf5nsw2 134 10 addition addition NN cord-261417-4pf5nsw2 134 11 of of IN cord-261417-4pf5nsw2 134 12 an an DT cord-261417-4pf5nsw2 134 13 NTP NTP NNP cord-261417-4pf5nsw2 134 14 to to IN cord-261417-4pf5nsw2 134 15 the the DT cord-261417-4pf5nsw2 134 16 3 3 CD cord-261417-4pf5nsw2 134 17 end end NN cord-261417-4pf5nsw2 134 18 of of IN cord-261417-4pf5nsw2 134 19 the the DT cord-261417-4pf5nsw2 134 20 capped cap VBN cord-261417-4pf5nsw2 134 21 primer primer NN cord-261417-4pf5nsw2 134 22 , , , cord-261417-4pf5nsw2 134 23 complementary complementary JJ cord-261417-4pf5nsw2 134 24 to to IN cord-261417-4pf5nsw2 134 25 the the DT cord-261417-4pf5nsw2 134 26 second second JJ cord-261417-4pf5nsw2 134 27 or or CC cord-261417-4pf5nsw2 134 28 third third JJ cord-261417-4pf5nsw2 134 29 residue residue NN cord-261417-4pf5nsw2 134 30 in in IN cord-261417-4pf5nsw2 134 31 the the DT cord-261417-4pf5nsw2 134 32 vRNA vrna JJ cord-261417-4pf5nsw2 134 33 template template NN cord-261417-4pf5nsw2 134 34 . . . cord-261417-4pf5nsw2 135 1 During during IN cord-261417-4pf5nsw2 135 2 elongation elongation NN cord-261417-4pf5nsw2 135 3 , , , cord-261417-4pf5nsw2 135 4 the the DT cord-261417-4pf5nsw2 135 5 5 5 CD cord-261417-4pf5nsw2 135 6 -capped -capped JJ cord-261417-4pf5nsw2 135 7 viral viral JJ cord-261417-4pf5nsw2 135 8 mRNA mrna NN cord-261417-4pf5nsw2 135 9 is be VBZ cord-261417-4pf5nsw2 135 10 separated separate VBN cord-261417-4pf5nsw2 135 11 from from IN cord-261417-4pf5nsw2 135 12 the the DT cord-261417-4pf5nsw2 135 13 vRNA vrna JJ cord-261417-4pf5nsw2 135 14 template template NN cord-261417-4pf5nsw2 135 15 by by IN cord-261417-4pf5nsw2 135 16 threading thread VBG cord-261417-4pf5nsw2 135 17 into into IN cord-261417-4pf5nsw2 135 18 their -PRON- PRP$ cord-261417-4pf5nsw2 135 19 respective respective JJ cord-261417-4pf5nsw2 135 20 exit exit NN cord-261417-4pf5nsw2 135 21 channels channel NNS cord-261417-4pf5nsw2 135 22 . . . cord-261417-4pf5nsw2 136 1 After after IN cord-261417-4pf5nsw2 136 2 elongation elongation NN cord-261417-4pf5nsw2 136 3 , , , cord-261417-4pf5nsw2 136 4 the the DT cord-261417-4pf5nsw2 136 5 viral viral JJ cord-261417-4pf5nsw2 136 6 mRNA mrna NN cord-261417-4pf5nsw2 136 7 is be VBZ cord-261417-4pf5nsw2 136 8 polyadenylated polyadenylate VBN cord-261417-4pf5nsw2 136 9 at at IN cord-261417-4pf5nsw2 136 10 an an DT cord-261417-4pf5nsw2 136 11 oligo oligo NN cord-261417-4pf5nsw2 136 12 - - HYPH cord-261417-4pf5nsw2 136 13 U u NN cord-261417-4pf5nsw2 136 14 stretch stretch NN cord-261417-4pf5nsw2 136 15 near near IN cord-261417-4pf5nsw2 136 16 the the DT cord-261417-4pf5nsw2 136 17 vRNA vrna JJ cord-261417-4pf5nsw2 136 18 5 5 CD cord-261417-4pf5nsw2 136 19 end end NN cord-261417-4pf5nsw2 136 20 [ [ -LRB- cord-261417-4pf5nsw2 136 21 65 65 CD cord-261417-4pf5nsw2 136 22 ] ] -RRB- cord-261417-4pf5nsw2 136 23 . . . cord-261417-4pf5nsw2 137 1 The the DT cord-261417-4pf5nsw2 137 2 capped capped JJ cord-261417-4pf5nsw2 137 3 viral viral JJ cord-261417-4pf5nsw2 137 4 mRNA mrna NN cord-261417-4pf5nsw2 137 5 can can MD cord-261417-4pf5nsw2 137 6 now now RB cord-261417-4pf5nsw2 137 7 be be VB cord-261417-4pf5nsw2 137 8 used use VBN cord-261417-4pf5nsw2 137 9 to to TO cord-261417-4pf5nsw2 137 10 translate translate VB cord-261417-4pf5nsw2 137 11 all all PDT cord-261417-4pf5nsw2 137 12 the the DT cord-261417-4pf5nsw2 137 13 necessary necessary JJ cord-261417-4pf5nsw2 137 14 viral viral JJ cord-261417-4pf5nsw2 137 15 proteins protein NNS cord-261417-4pf5nsw2 137 16 , , , cord-261417-4pf5nsw2 137 17 whereas whereas IN cord-261417-4pf5nsw2 137 18 the the DT cord-261417-4pf5nsw2 137 19 vRNA vRNA NNS cord-261417-4pf5nsw2 137 20 can can MD cord-261417-4pf5nsw2 137 21 be be VB cord-261417-4pf5nsw2 137 22 packaged package VBN cord-261417-4pf5nsw2 137 23 , , , cord-261417-4pf5nsw2 137 24 re re NNS cord-261417-4pf5nsw2 137 25 - - VBN cord-261417-4pf5nsw2 137 26 used use VBN cord-261417-4pf5nsw2 137 27 as as IN cord-261417-4pf5nsw2 137 28 template template NN cord-261417-4pf5nsw2 137 29 , , , cord-261417-4pf5nsw2 137 30 or or CC cord-261417-4pf5nsw2 137 31 degraded degrade VBN cord-261417-4pf5nsw2 137 32 . . . cord-261417-4pf5nsw2 138 1 Small small JJ cord-261417-4pf5nsw2 138 2 host host NN cord-261417-4pf5nsw2 138 3 non non JJ cord-261417-4pf5nsw2 138 4 - - JJ cord-261417-4pf5nsw2 138 5 coding coding JJ cord-261417-4pf5nsw2 138 6 RNAs rna NNS cord-261417-4pf5nsw2 138 7 ( ( -LRB- cord-261417-4pf5nsw2 138 8 snRNAs snRNAs NNP cord-261417-4pf5nsw2 138 9 ) ) -RRB- cord-261417-4pf5nsw2 138 10 , , , cord-261417-4pf5nsw2 138 11 especially especially RB cord-261417-4pf5nsw2 138 12 U1 U1 NNP cord-261417-4pf5nsw2 138 13 and and CC cord-261417-4pf5nsw2 138 14 U2 U2 NNP cord-261417-4pf5nsw2 138 15 snRNA snRNA NNP cord-261417-4pf5nsw2 138 16 , , , cord-261417-4pf5nsw2 138 17 are be VBP cord-261417-4pf5nsw2 138 18 the the DT cord-261417-4pf5nsw2 138 19 preferred preferred JJ cord-261417-4pf5nsw2 138 20 targets target NNS cord-261417-4pf5nsw2 138 21 for for IN cord-261417-4pf5nsw2 138 22 cap cap NN cord-261417-4pf5nsw2 138 23 - - HYPH cord-261417-4pf5nsw2 138 24 snatching snatching NN cord-261417-4pf5nsw2 138 25 , , , cord-261417-4pf5nsw2 138 26 rather rather RB cord-261417-4pf5nsw2 138 27 than than IN cord-261417-4pf5nsw2 138 28 mRNAs mrnas CD cord-261417-4pf5nsw2 138 29 or or CC cord-261417-4pf5nsw2 138 30 pre pre VB cord-261417-4pf5nsw2 138 31 - - JJ cord-261417-4pf5nsw2 138 32 mRNAs mrnas JJ cord-261417-4pf5nsw2 138 33 [ [ -LRB- cord-261417-4pf5nsw2 138 34 62 62 CD cord-261417-4pf5nsw2 138 35 ] ] -RRB- cord-261417-4pf5nsw2 138 36 [ [ -LRB- cord-261417-4pf5nsw2 138 37 63 63 CD cord-261417-4pf5nsw2 138 38 ] ] -RRB- cord-261417-4pf5nsw2 138 39 [ [ -LRB- cord-261417-4pf5nsw2 138 40 64 64 CD cord-261417-4pf5nsw2 138 41 ] ] -RRB- cord-261417-4pf5nsw2 138 42 . . . cord-261417-4pf5nsw2 139 1 Why why WRB cord-261417-4pf5nsw2 139 2 the the DT cord-261417-4pf5nsw2 139 3 virus virus NN cord-261417-4pf5nsw2 139 4 prefers prefer VBZ cord-261417-4pf5nsw2 139 5 to to TO cord-261417-4pf5nsw2 139 6 use use VB cord-261417-4pf5nsw2 139 7 these these DT cord-261417-4pf5nsw2 139 8 snRNAs snrna NNS cord-261417-4pf5nsw2 139 9 as as IN cord-261417-4pf5nsw2 139 10 targets target NNS cord-261417-4pf5nsw2 139 11 has have VBZ cord-261417-4pf5nsw2 139 12 yet yet RB cord-261417-4pf5nsw2 139 13 to to TO cord-261417-4pf5nsw2 139 14 be be VB cord-261417-4pf5nsw2 139 15 experimentally experimentally RB cord-261417-4pf5nsw2 139 16 established establish VBN cord-261417-4pf5nsw2 139 17 , , , cord-261417-4pf5nsw2 139 18 but but CC cord-261417-4pf5nsw2 139 19 it -PRON- PRP cord-261417-4pf5nsw2 139 20 has have VBZ cord-261417-4pf5nsw2 139 21 been be VBN cord-261417-4pf5nsw2 139 22 proposed propose VBN cord-261417-4pf5nsw2 139 23 that that IN cord-261417-4pf5nsw2 139 24 the the DT cord-261417-4pf5nsw2 139 25 selective selective JJ cord-261417-4pf5nsw2 139 26 de de NN cord-261417-4pf5nsw2 139 27 - - NN cord-261417-4pf5nsw2 139 28 capping capping NN cord-261417-4pf5nsw2 139 29 of of IN cord-261417-4pf5nsw2 139 30 U1 u1 NN cord-261417-4pf5nsw2 139 31 and and CC cord-261417-4pf5nsw2 139 32 U2 U2 NNP cord-261417-4pf5nsw2 139 33 RNAs rna NNS cord-261417-4pf5nsw2 139 34 in in IN cord-261417-4pf5nsw2 139 35 combination combination NN cord-261417-4pf5nsw2 139 36 with with IN cord-261417-4pf5nsw2 139 37 the the DT cord-261417-4pf5nsw2 139 38 binding binding NN cord-261417-4pf5nsw2 139 39 of of IN cord-261417-4pf5nsw2 139 40 the the DT cord-261417-4pf5nsw2 139 41 viral viral JJ cord-261417-4pf5nsw2 139 42 NS1 ns1 NN cord-261417-4pf5nsw2 139 43 protein protein NN cord-261417-4pf5nsw2 139 44 to to IN cord-261417-4pf5nsw2 139 45 U6 U6 NNP cord-261417-4pf5nsw2 139 46 snRNA snrna NN cord-261417-4pf5nsw2 139 47 may may MD cord-261417-4pf5nsw2 139 48 serve serve VB cord-261417-4pf5nsw2 139 49 to to TO cord-261417-4pf5nsw2 139 50 inhibit inhibit VB cord-261417-4pf5nsw2 139 51 host host NN cord-261417-4pf5nsw2 139 52 pre pre JJ cord-261417-4pf5nsw2 139 53 - - JJ cord-261417-4pf5nsw2 139 54 mRNA mrna JJ cord-261417-4pf5nsw2 139 55 splicing splicing NN cord-261417-4pf5nsw2 139 56 [ [ -LRB- cord-261417-4pf5nsw2 139 57 66 66 CD cord-261417-4pf5nsw2 139 58 ] ] -RRB- cord-261417-4pf5nsw2 139 59 . . . cord-261417-4pf5nsw2 140 1 This this DT cord-261417-4pf5nsw2 140 2 will will MD cord-261417-4pf5nsw2 140 3 allow allow VB cord-261417-4pf5nsw2 140 4 the the DT cord-261417-4pf5nsw2 140 5 PB2-cap PB2-cap NNP cord-261417-4pf5nsw2 140 6 domain domain NN cord-261417-4pf5nsw2 140 7 to to TO cord-261417-4pf5nsw2 140 8 bind bind VB cord-261417-4pf5nsw2 140 9 the the DT cord-261417-4pf5nsw2 140 10 cap cap NN cord-261417-4pf5nsw2 140 11 and and CC cord-261417-4pf5nsw2 140 12 to to TO cord-261417-4pf5nsw2 140 13 direct direct VB cord-261417-4pf5nsw2 140 14 the the DT cord-261417-4pf5nsw2 140 15 nascent nascent JJ cord-261417-4pf5nsw2 140 16 RNA RNA NNP cord-261417-4pf5nsw2 140 17 towards towards IN cord-261417-4pf5nsw2 140 18 PA PA NNP cord-261417-4pf5nsw2 140 19 - - HYPH cord-261417-4pf5nsw2 140 20 endo endo NNP cord-261417-4pf5nsw2 140 21 . . . cord-261417-4pf5nsw2 141 1 After after IN cord-261417-4pf5nsw2 141 2 cleavage cleavage NN cord-261417-4pf5nsw2 141 3 the the DT cord-261417-4pf5nsw2 141 4 nascent nascent JJ cord-261417-4pf5nsw2 141 5 RNA RNA NNP cord-261417-4pf5nsw2 141 6 will will MD cord-261417-4pf5nsw2 141 7 be be VB cord-261417-4pf5nsw2 141 8 loaded load VBN cord-261417-4pf5nsw2 141 9 into into IN cord-261417-4pf5nsw2 141 10 the the DT cord-261417-4pf5nsw2 141 11 active active JJ cord-261417-4pf5nsw2 141 12 domain domain NN cord-261417-4pf5nsw2 141 13 of of IN cord-261417-4pf5nsw2 141 14 FluPol FluPol NNP cord-261417-4pf5nsw2 141 15 where where WRB cord-261417-4pf5nsw2 141 16 it -PRON- PRP cord-261417-4pf5nsw2 141 17 will will MD cord-261417-4pf5nsw2 141 18 be be VB cord-261417-4pf5nsw2 141 19 used use VBN cord-261417-4pf5nsw2 141 20 to to TO cord-261417-4pf5nsw2 141 21 prime prime VB cord-261417-4pf5nsw2 141 22 the the DT cord-261417-4pf5nsw2 141 23 3′ 3′ CD cord-261417-4pf5nsw2 141 24 end end NN cord-261417-4pf5nsw2 141 25 of of IN cord-261417-4pf5nsw2 141 26 the the DT cord-261417-4pf5nsw2 141 27 vRNA vRNA JJS cord-261417-4pf5nsw2 141 28 , , , cord-261417-4pf5nsw2 141 29 allowing allow VBG cord-261417-4pf5nsw2 141 30 elongation elongation NN cord-261417-4pf5nsw2 141 31 of of IN cord-261417-4pf5nsw2 141 32 the the DT cord-261417-4pf5nsw2 141 33 RNA RNA NNP cord-261417-4pf5nsw2 141 34 primer primer NN cord-261417-4pf5nsw2 141 35 from from IN cord-261417-4pf5nsw2 141 36 5′ 5′ CD cord-261417-4pf5nsw2 141 37 to to IN cord-261417-4pf5nsw2 141 38 3′ 3′ CD cord-261417-4pf5nsw2 141 39 direction direction NN cord-261417-4pf5nsw2 141 40 ( ( -LRB- cord-261417-4pf5nsw2 141 41 indicated indicate VBN cord-261417-4pf5nsw2 141 42 with with IN cord-261417-4pf5nsw2 141 43 black black JJ cord-261417-4pf5nsw2 141 44 arrow arrow NN cord-261417-4pf5nsw2 141 45 ) ) -RRB- cord-261417-4pf5nsw2 141 46 . . . cord-261417-4pf5nsw2 142 1 Elongation elongation NN cord-261417-4pf5nsw2 142 2 is be VBZ cord-261417-4pf5nsw2 142 3 the the DT cord-261417-4pf5nsw2 142 4 repeated repeat VBN cord-261417-4pf5nsw2 142 5 addition addition NN cord-261417-4pf5nsw2 142 6 of of IN cord-261417-4pf5nsw2 142 7 a a DT cord-261417-4pf5nsw2 142 8 nucleoside nucleoside NN cord-261417-4pf5nsw2 142 9 monophosphate monophosphate NN cord-261417-4pf5nsw2 142 10 ( ( -LRB- cord-261417-4pf5nsw2 142 11 NMP NMP NNP cord-261417-4pf5nsw2 142 12 ) ) -RRB- cord-261417-4pf5nsw2 142 13 to to IN cord-261417-4pf5nsw2 142 14 the the DT cord-261417-4pf5nsw2 142 15 3′ 3′ CD cord-261417-4pf5nsw2 142 16 end end NN cord-261417-4pf5nsw2 142 17 of of IN cord-261417-4pf5nsw2 142 18 the the DT cord-261417-4pf5nsw2 142 19 growing grow VBG cord-261417-4pf5nsw2 142 20 RNA RNA NNP cord-261417-4pf5nsw2 142 21 chain chain NN cord-261417-4pf5nsw2 142 22 . . . cord-261417-4pf5nsw2 143 1 Progressive Progressive NNP cord-261417-4pf5nsw2 143 2 RNA RNA NNP cord-261417-4pf5nsw2 143 3 synthesis synthesis NN cord-261417-4pf5nsw2 143 4 during during IN cord-261417-4pf5nsw2 143 5 the the DT cord-261417-4pf5nsw2 143 6 elongation elongation NN cord-261417-4pf5nsw2 143 7 stage stage NN cord-261417-4pf5nsw2 143 8 can can MD cord-261417-4pf5nsw2 143 9 be be VB cord-261417-4pf5nsw2 143 10 affected affect VBN cord-261417-4pf5nsw2 143 11 by by IN cord-261417-4pf5nsw2 143 12 several several JJ cord-261417-4pf5nsw2 143 13 hurdles hurdle NNS cord-261417-4pf5nsw2 143 14 , , , cord-261417-4pf5nsw2 143 15 including include VBG cord-261417-4pf5nsw2 143 16 transcriptional transcriptional JJ cord-261417-4pf5nsw2 143 17 pause pause NN cord-261417-4pf5nsw2 143 18 sites site NNS cord-261417-4pf5nsw2 143 19 , , , cord-261417-4pf5nsw2 143 20 that that IN cord-261417-4pf5nsw2 143 21 RNAPII RNAPII NNP cord-261417-4pf5nsw2 143 22 must must MD cord-261417-4pf5nsw2 143 23 overcome overcome VB cord-261417-4pf5nsw2 143 24 [ [ -LRB- cord-261417-4pf5nsw2 143 25 67 67 CD cord-261417-4pf5nsw2 143 26 ] ] -RRB- cord-261417-4pf5nsw2 143 27 . . . cord-261417-4pf5nsw2 144 1 These these DT cord-261417-4pf5nsw2 144 2 purple purple NN cord-261417-4pf5nsw2 144 3 ) ) -RRB- cord-261417-4pf5nsw2 144 4 is be VBZ cord-261417-4pf5nsw2 144 5 circularized circularize VBN cord-261417-4pf5nsw2 144 6 with with IN cord-261417-4pf5nsw2 144 7 the the DT cord-261417-4pf5nsw2 144 8 extreme extreme JJ cord-261417-4pf5nsw2 144 9 5 5 CD cord-261417-4pf5nsw2 144 10 end end NN cord-261417-4pf5nsw2 144 11 docked dock VBN cord-261417-4pf5nsw2 144 12 in in IN cord-261417-4pf5nsw2 144 13 a a DT cord-261417-4pf5nsw2 144 14 pocket pocket NN cord-261417-4pf5nsw2 144 15 formed form VBN cord-261417-4pf5nsw2 144 16 by by IN cord-261417-4pf5nsw2 144 17 PA PA NNP cord-261417-4pf5nsw2 144 18 - - HYPH cord-261417-4pf5nsw2 144 19 C C NNP cord-261417-4pf5nsw2 144 20 and and CC cord-261417-4pf5nsw2 144 21 PB1 PB1 NNP cord-261417-4pf5nsw2 144 22 and and CC cord-261417-4pf5nsw2 144 23 the the DT cord-261417-4pf5nsw2 144 24 3 3 CD cord-261417-4pf5nsw2 144 25 end end NN cord-261417-4pf5nsw2 144 26 loaded load VBN cord-261417-4pf5nsw2 144 27 in in IN cord-261417-4pf5nsw2 144 28 the the DT cord-261417-4pf5nsw2 144 29 FluPol FluPol NNP cord-261417-4pf5nsw2 144 30 active active JJ cord-261417-4pf5nsw2 144 31 center center NN cord-261417-4pf5nsw2 144 32 ( ( -LRB- cord-261417-4pf5nsw2 144 33 yellow yellow NNP cord-261417-4pf5nsw2 144 34 star star NNP cord-261417-4pf5nsw2 144 35 ) ) -RRB- cord-261417-4pf5nsw2 144 36 ; ; : cord-261417-4pf5nsw2 144 37 ( ( -LRB- cord-261417-4pf5nsw2 144 38 E e LS cord-261417-4pf5nsw2 144 39 ) ) -RRB- cord-261417-4pf5nsw2 144 40 the the DT cord-261417-4pf5nsw2 144 41 first first JJ cord-261417-4pf5nsw2 144 42 step step NN cord-261417-4pf5nsw2 144 43 in in IN cord-261417-4pf5nsw2 144 44 cap cap NN cord-261417-4pf5nsw2 144 45 - - HYPH cord-261417-4pf5nsw2 144 46 snatching snatching NN cord-261417-4pf5nsw2 144 47 is be VBZ cord-261417-4pf5nsw2 144 48 the the DT cord-261417-4pf5nsw2 144 49 recognition recognition NN cord-261417-4pf5nsw2 144 50 and and CC cord-261417-4pf5nsw2 144 51 binding binding NN cord-261417-4pf5nsw2 144 52 of of IN cord-261417-4pf5nsw2 144 53 FluPol FluPol NNP cord-261417-4pf5nsw2 144 54 to to IN cord-261417-4pf5nsw2 144 55 the the DT cord-261417-4pf5nsw2 144 56 phosphorylated phosphorylated JJ cord-261417-4pf5nsw2 144 57 Ser5 Ser5 NNPS cord-261417-4pf5nsw2 144 58 of of IN cord-261417-4pf5nsw2 144 59 RNAPII RNAPII NNP cord-261417-4pf5nsw2 144 60 through through IN cord-261417-4pf5nsw2 144 61 its -PRON- PRP$ cord-261417-4pf5nsw2 144 62 PA PA NNP cord-261417-4pf5nsw2 144 63 - - HYPH cord-261417-4pf5nsw2 144 64 C C NNP cord-261417-4pf5nsw2 144 65 domain domain NN cord-261417-4pf5nsw2 144 66 . . . cord-261417-4pf5nsw2 145 1 This this DT cord-261417-4pf5nsw2 145 2 will will MD cord-261417-4pf5nsw2 145 3 allow allow VB cord-261417-4pf5nsw2 145 4 the the DT cord-261417-4pf5nsw2 145 5 PB2-cap PB2-cap NNP cord-261417-4pf5nsw2 145 6 domain domain NN cord-261417-4pf5nsw2 145 7 to to TO cord-261417-4pf5nsw2 145 8 bind bind VB cord-261417-4pf5nsw2 145 9 the the DT cord-261417-4pf5nsw2 145 10 cap cap NN cord-261417-4pf5nsw2 145 11 and and CC cord-261417-4pf5nsw2 145 12 to to TO cord-261417-4pf5nsw2 145 13 direct direct VB cord-261417-4pf5nsw2 145 14 the the DT cord-261417-4pf5nsw2 145 15 nascent nascent JJ cord-261417-4pf5nsw2 145 16 RNA RNA NNP cord-261417-4pf5nsw2 145 17 towards towards IN cord-261417-4pf5nsw2 145 18 PA PA NNP cord-261417-4pf5nsw2 145 19 - - HYPH cord-261417-4pf5nsw2 145 20 endo endo NNP cord-261417-4pf5nsw2 145 21 . . . cord-261417-4pf5nsw2 146 1 After after IN cord-261417-4pf5nsw2 146 2 cleavage cleavage NN cord-261417-4pf5nsw2 146 3 the the DT cord-261417-4pf5nsw2 146 4 nascent nascent JJ cord-261417-4pf5nsw2 146 5 RNA RNA NNP cord-261417-4pf5nsw2 146 6 will will MD cord-261417-4pf5nsw2 146 7 be be VB cord-261417-4pf5nsw2 146 8 loaded load VBN cord-261417-4pf5nsw2 146 9 into into IN cord-261417-4pf5nsw2 146 10 the the DT cord-261417-4pf5nsw2 146 11 active active JJ cord-261417-4pf5nsw2 146 12 domain domain NN cord-261417-4pf5nsw2 146 13 of of IN cord-261417-4pf5nsw2 146 14 FluPol FluPol NNP cord-261417-4pf5nsw2 146 15 where where WRB cord-261417-4pf5nsw2 146 16 it -PRON- PRP cord-261417-4pf5nsw2 146 17 will will MD cord-261417-4pf5nsw2 146 18 be be VB cord-261417-4pf5nsw2 146 19 used use VBN cord-261417-4pf5nsw2 146 20 to to TO cord-261417-4pf5nsw2 146 21 prime prime VB cord-261417-4pf5nsw2 146 22 the the DT cord-261417-4pf5nsw2 146 23 3 3 CD cord-261417-4pf5nsw2 146 24 end end NN cord-261417-4pf5nsw2 146 25 of of IN cord-261417-4pf5nsw2 146 26 the the DT cord-261417-4pf5nsw2 146 27 vRNA vRNA JJS cord-261417-4pf5nsw2 146 28 , , , cord-261417-4pf5nsw2 146 29 allowing allow VBG cord-261417-4pf5nsw2 146 30 elongation elongation NN cord-261417-4pf5nsw2 146 31 of of IN cord-261417-4pf5nsw2 146 32 the the DT cord-261417-4pf5nsw2 146 33 RNA RNA NNP cord-261417-4pf5nsw2 146 34 primer primer NN cord-261417-4pf5nsw2 146 35 from from IN cord-261417-4pf5nsw2 146 36 5 5 CD cord-261417-4pf5nsw2 146 37 to to TO cord-261417-4pf5nsw2 146 38 3 3 CD cord-261417-4pf5nsw2 146 39 direction direction NN cord-261417-4pf5nsw2 146 40 ( ( -LRB- cord-261417-4pf5nsw2 146 41 indicated indicate VBN cord-261417-4pf5nsw2 146 42 with with IN cord-261417-4pf5nsw2 146 43 black black JJ cord-261417-4pf5nsw2 146 44 arrow arrow NN cord-261417-4pf5nsw2 146 45 ) ) -RRB- cord-261417-4pf5nsw2 146 46 . . . cord-261417-4pf5nsw2 147 1 Elongation elongation NN cord-261417-4pf5nsw2 147 2 is be VBZ cord-261417-4pf5nsw2 147 3 the the DT cord-261417-4pf5nsw2 147 4 repeated repeat VBN cord-261417-4pf5nsw2 147 5 addition addition NN cord-261417-4pf5nsw2 147 6 of of IN cord-261417-4pf5nsw2 147 7 a a DT cord-261417-4pf5nsw2 147 8 nucleoside nucleoside NN cord-261417-4pf5nsw2 147 9 monophosphate monophosphate NN cord-261417-4pf5nsw2 147 10 ( ( -LRB- cord-261417-4pf5nsw2 147 11 NMP NMP NNP cord-261417-4pf5nsw2 147 12 ) ) -RRB- cord-261417-4pf5nsw2 147 13 to to IN cord-261417-4pf5nsw2 147 14 the the DT cord-261417-4pf5nsw2 147 15 3 3 CD cord-261417-4pf5nsw2 147 16 end end NN cord-261417-4pf5nsw2 147 17 of of IN cord-261417-4pf5nsw2 147 18 the the DT cord-261417-4pf5nsw2 147 19 growing grow VBG cord-261417-4pf5nsw2 147 20 RNA RNA NNP cord-261417-4pf5nsw2 147 21 chain chain NN cord-261417-4pf5nsw2 147 22 . . . cord-261417-4pf5nsw2 148 1 Progressive Progressive NNP cord-261417-4pf5nsw2 148 2 RNA RNA NNP cord-261417-4pf5nsw2 148 3 synthesis synthesis NN cord-261417-4pf5nsw2 148 4 during during IN cord-261417-4pf5nsw2 148 5 the the DT cord-261417-4pf5nsw2 148 6 elongation elongation NN cord-261417-4pf5nsw2 148 7 stage stage NN cord-261417-4pf5nsw2 148 8 can can MD cord-261417-4pf5nsw2 148 9 be be VB cord-261417-4pf5nsw2 148 10 affected affect VBN cord-261417-4pf5nsw2 148 11 by by IN cord-261417-4pf5nsw2 148 12 several several JJ cord-261417-4pf5nsw2 148 13 hurdles hurdle NNS cord-261417-4pf5nsw2 148 14 , , , cord-261417-4pf5nsw2 148 15 including include VBG cord-261417-4pf5nsw2 148 16 transcriptional transcriptional JJ cord-261417-4pf5nsw2 148 17 pause pause NN cord-261417-4pf5nsw2 148 18 sites site NNS cord-261417-4pf5nsw2 148 19 , , , cord-261417-4pf5nsw2 148 20 that that IN cord-261417-4pf5nsw2 148 21 RNAPII RNAPII NNP cord-261417-4pf5nsw2 148 22 must must MD cord-261417-4pf5nsw2 148 23 overcome overcome VB cord-261417-4pf5nsw2 148 24 [ [ -LRB- cord-261417-4pf5nsw2 148 25 67 67 CD cord-261417-4pf5nsw2 148 26 ] ] -RRB- cord-261417-4pf5nsw2 148 27 . . . cord-261417-4pf5nsw2 149 1 These these DT cord-261417-4pf5nsw2 149 2 transcriptional transcriptional JJ cord-261417-4pf5nsw2 149 3 pauses pause NNS cord-261417-4pf5nsw2 149 4 can can MD cord-261417-4pf5nsw2 149 5 be be VB cord-261417-4pf5nsw2 149 6 used use VBN cord-261417-4pf5nsw2 149 7 to to TO cord-261417-4pf5nsw2 149 8 create create VB cord-261417-4pf5nsw2 149 9 a a DT cord-261417-4pf5nsw2 149 10 time time NN cord-261417-4pf5nsw2 149 11 window window NN cord-261417-4pf5nsw2 149 12 for for IN cord-261417-4pf5nsw2 149 13 co co JJ cord-261417-4pf5nsw2 149 14 - - JJ cord-261417-4pf5nsw2 149 15 transcriptional transcriptional JJ cord-261417-4pf5nsw2 149 16 events event NNS cord-261417-4pf5nsw2 149 17 such such JJ cord-261417-4pf5nsw2 149 18 as as IN cord-261417-4pf5nsw2 149 19 splicing splicing NN cord-261417-4pf5nsw2 149 20 , , , cord-261417-4pf5nsw2 149 21 nucleotide nucleotide JJ cord-261417-4pf5nsw2 149 22 modification modification NN cord-261417-4pf5nsw2 149 23 , , , cord-261417-4pf5nsw2 149 24 or or CC cord-261417-4pf5nsw2 149 25 RNA RNA NNP cord-261417-4pf5nsw2 149 26 processing processing NN cord-261417-4pf5nsw2 149 27 . . . cord-261417-4pf5nsw2 150 1 Pauses pause NNS cord-261417-4pf5nsw2 150 2 also also RB cord-261417-4pf5nsw2 150 3 yield yield VB cord-261417-4pf5nsw2 150 4 opportunities opportunity NNS cord-261417-4pf5nsw2 150 5 to to TO cord-261417-4pf5nsw2 150 6 regulate regulate VB cord-261417-4pf5nsw2 150 7 transcription transcription NN cord-261417-4pf5nsw2 150 8 in in IN cord-261417-4pf5nsw2 150 9 response response NN cord-261417-4pf5nsw2 150 10 to to IN cord-261417-4pf5nsw2 150 11 intra intra JJ cord-261417-4pf5nsw2 150 12 - - JJ cord-261417-4pf5nsw2 150 13 and and CC cord-261417-4pf5nsw2 150 14 extra extra JJ cord-261417-4pf5nsw2 150 15 - - JJ cord-261417-4pf5nsw2 150 16 cellular cellular JJ cord-261417-4pf5nsw2 150 17 cues cue NNS cord-261417-4pf5nsw2 150 18 [ [ -LRB- cord-261417-4pf5nsw2 150 19 68 68 CD cord-261417-4pf5nsw2 150 20 ] ] -RRB- cord-261417-4pf5nsw2 150 21 . . . cord-261417-4pf5nsw2 151 1 At at IN cord-261417-4pf5nsw2 151 2 most most JJS cord-261417-4pf5nsw2 151 3 eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 151 4 promoters promoter NNS cord-261417-4pf5nsw2 151 5 , , , cord-261417-4pf5nsw2 151 6 major major JJ cord-261417-4pf5nsw2 151 7 transcriptional transcriptional NN cord-261417-4pf5nsw2 151 8 pauses pause NNS cord-261417-4pf5nsw2 151 9 typically typically RB cord-261417-4pf5nsw2 151 10 occur occur VBP cord-261417-4pf5nsw2 151 11 within within IN cord-261417-4pf5nsw2 151 12 20 20 CD cord-261417-4pf5nsw2 151 13 - - SYM cord-261417-4pf5nsw2 151 14 60 60 CD cord-261417-4pf5nsw2 151 15 nt nt RB cord-261417-4pf5nsw2 151 16 after after IN cord-261417-4pf5nsw2 151 17 transcription transcription NN cord-261417-4pf5nsw2 151 18 initiation initiation NN cord-261417-4pf5nsw2 151 19 [ [ -LRB- cord-261417-4pf5nsw2 151 20 69 69 CD cord-261417-4pf5nsw2 151 21 ] ] -RRB- cord-261417-4pf5nsw2 151 22 . . . cord-261417-4pf5nsw2 152 1 These these DT cord-261417-4pf5nsw2 152 2 promoter promoter NN cord-261417-4pf5nsw2 152 3 - - HYPH cord-261417-4pf5nsw2 152 4 proximal proximal JJ cord-261417-4pf5nsw2 152 5 pauses pause NNS cord-261417-4pf5nsw2 152 6 are be VBP cord-261417-4pf5nsw2 152 7 induced induce VBN cord-261417-4pf5nsw2 152 8 by by IN cord-261417-4pf5nsw2 152 9 a a DT cord-261417-4pf5nsw2 152 10 myriad myriad NN cord-261417-4pf5nsw2 152 11 of of IN cord-261417-4pf5nsw2 152 12 factors factor NNS cord-261417-4pf5nsw2 152 13 , , , cord-261417-4pf5nsw2 152 14 including include VBG cord-261417-4pf5nsw2 152 15 negative negative JJ cord-261417-4pf5nsw2 152 16 elongation elongation NN cord-261417-4pf5nsw2 152 17 factor factor NN cord-261417-4pf5nsw2 152 18 ( ( -LRB- cord-261417-4pf5nsw2 152 19 NELF NELF NNP cord-261417-4pf5nsw2 152 20 ) ) -RRB- cord-261417-4pf5nsw2 152 21 and and CC cord-261417-4pf5nsw2 152 22 nascent nascent JJ cord-261417-4pf5nsw2 152 23 RNA RNA NNP cord-261417-4pf5nsw2 152 24 structures structure NNS cord-261417-4pf5nsw2 152 25 . . . cord-261417-4pf5nsw2 153 1 These these DT cord-261417-4pf5nsw2 153 2 pauses pause NNS cord-261417-4pf5nsw2 153 3 give give VBP cord-261417-4pf5nsw2 153 4 opportunities opportunity NNS cord-261417-4pf5nsw2 153 5 for for IN cord-261417-4pf5nsw2 153 6 the the DT cord-261417-4pf5nsw2 153 7 organism organism NN cord-261417-4pf5nsw2 153 8 to to TO cord-261417-4pf5nsw2 153 9 regulate regulate VB cord-261417-4pf5nsw2 153 10 transcription transcription NN cord-261417-4pf5nsw2 153 11 at at IN cord-261417-4pf5nsw2 153 12 an an DT cord-261417-4pf5nsw2 153 13 early early JJ cord-261417-4pf5nsw2 153 14 time time NN cord-261417-4pf5nsw2 153 15 point point NN cord-261417-4pf5nsw2 153 16 . . . cord-261417-4pf5nsw2 154 1 A a DT cord-261417-4pf5nsw2 154 2 promoter promoter NN cord-261417-4pf5nsw2 154 3 - - HYPH cord-261417-4pf5nsw2 154 4 proximal proximal JJ cord-261417-4pf5nsw2 154 5 pause pause NN cord-261417-4pf5nsw2 154 6 will will MD cord-261417-4pf5nsw2 154 7 often often RB cord-261417-4pf5nsw2 154 8 allow allow VB cord-261417-4pf5nsw2 154 9 the the DT cord-261417-4pf5nsw2 154 10 nascent nascent JJ cord-261417-4pf5nsw2 154 11 RNA RNA NNP cord-261417-4pf5nsw2 154 12 to to TO cord-261417-4pf5nsw2 154 13 fold fold VB cord-261417-4pf5nsw2 154 14 a a DT cord-261417-4pf5nsw2 154 15 structure structure NN cord-261417-4pf5nsw2 154 16 that that WDT cord-261417-4pf5nsw2 154 17 can can MD cord-261417-4pf5nsw2 154 18 serve serve VB cord-261417-4pf5nsw2 154 19 as as IN cord-261417-4pf5nsw2 154 20 a a DT cord-261417-4pf5nsw2 154 21 protein protein NN cord-261417-4pf5nsw2 154 22 - - HYPH cord-261417-4pf5nsw2 154 23 recruiting recruit VBG cord-261417-4pf5nsw2 154 24 scaffold scaffold NN cord-261417-4pf5nsw2 154 25 [ [ -LRB- cord-261417-4pf5nsw2 154 26 70 70 CD cord-261417-4pf5nsw2 154 27 ] ] -RRB- cord-261417-4pf5nsw2 154 28 . . . cord-261417-4pf5nsw2 155 1 Additional additional JJ cord-261417-4pf5nsw2 155 2 transcription transcription NN cord-261417-4pf5nsw2 155 3 factors factor NNS cord-261417-4pf5nsw2 155 4 ( ( -LRB- cord-261417-4pf5nsw2 155 5 TFs tf NNS cord-261417-4pf5nsw2 155 6 ) ) -RRB- cord-261417-4pf5nsw2 155 7 can can MD cord-261417-4pf5nsw2 155 8 be be VB cord-261417-4pf5nsw2 155 9 recruited recruit VBN cord-261417-4pf5nsw2 155 10 during during IN cord-261417-4pf5nsw2 155 11 this this DT cord-261417-4pf5nsw2 155 12 step step NN cord-261417-4pf5nsw2 155 13 . . . cord-261417-4pf5nsw2 156 1 Three three CD cord-261417-4pf5nsw2 156 2 distinct distinct JJ cord-261417-4pf5nsw2 156 3 modes mode NNS cord-261417-4pf5nsw2 156 4 of of IN cord-261417-4pf5nsw2 156 5 action action NN cord-261417-4pf5nsw2 156 6 can can MD cord-261417-4pf5nsw2 156 7 be be VB cord-261417-4pf5nsw2 156 8 envisaged envisage VBN cord-261417-4pf5nsw2 156 9 whereby whereby WRB cord-261417-4pf5nsw2 156 10 TF TF NNP cord-261417-4pf5nsw2 156 11 - - HYPH cord-261417-4pf5nsw2 156 12 interacting interact VBG cord-261417-4pf5nsw2 156 13 RNAs rna NNS cord-261417-4pf5nsw2 156 14 might may MD cord-261417-4pf5nsw2 156 15 affect affect VB cord-261417-4pf5nsw2 156 16 transcription transcription NN cord-261417-4pf5nsw2 156 17 . . . cord-261417-4pf5nsw2 157 1 They -PRON- PRP cord-261417-4pf5nsw2 157 2 could could MD cord-261417-4pf5nsw2 157 3 act act VB cord-261417-4pf5nsw2 157 4 as as IN cord-261417-4pf5nsw2 157 5 ( ( -LRB- cord-261417-4pf5nsw2 157 6 i i NN cord-261417-4pf5nsw2 157 7 ) ) -RRB- cord-261417-4pf5nsw2 157 8 scaffolds scaffold NNS cord-261417-4pf5nsw2 157 9 to to TO cord-261417-4pf5nsw2 157 10 recruit recruit VB cord-261417-4pf5nsw2 157 11 one one CD cord-261417-4pf5nsw2 157 12 or or CC cord-261417-4pf5nsw2 157 13 more more JJR cord-261417-4pf5nsw2 157 14 TFs tf NNS cord-261417-4pf5nsw2 157 15 [ [ -LRB- cord-261417-4pf5nsw2 157 16 71 71 CD cord-261417-4pf5nsw2 157 17 ] ] -RRB- cord-261417-4pf5nsw2 157 18 [ [ -LRB- cord-261417-4pf5nsw2 157 19 72 72 CD cord-261417-4pf5nsw2 157 20 ] ] -RRB- cord-261417-4pf5nsw2 157 21 [ [ -LRB- cord-261417-4pf5nsw2 157 22 73 73 CD cord-261417-4pf5nsw2 157 23 ] ] -RRB- cord-261417-4pf5nsw2 157 24 ; ; : cord-261417-4pf5nsw2 157 25 ( ( -LRB- cord-261417-4pf5nsw2 157 26 ii ii NN cord-261417-4pf5nsw2 157 27 ) ) -RRB- cord-261417-4pf5nsw2 157 28 competitors competitor NNS cord-261417-4pf5nsw2 157 29 , , , cord-261417-4pf5nsw2 157 30 regulating regulate VBG cord-261417-4pf5nsw2 157 31 the the DT cord-261417-4pf5nsw2 157 32 binding binding NN cord-261417-4pf5nsw2 157 33 or or CC cord-261417-4pf5nsw2 157 34 release release NN cord-261417-4pf5nsw2 157 35 of of IN cord-261417-4pf5nsw2 157 36 a a DT cord-261417-4pf5nsw2 157 37 TF TF NNP cord-261417-4pf5nsw2 157 38 [ [ -LRB- cord-261417-4pf5nsw2 157 39 74 74 CD cord-261417-4pf5nsw2 157 40 ] ] -RRB- cord-261417-4pf5nsw2 157 41 ; ; : cord-261417-4pf5nsw2 157 42 or or CC cord-261417-4pf5nsw2 157 43 ( ( -LRB- cord-261417-4pf5nsw2 157 44 iii iii NN cord-261417-4pf5nsw2 157 45 ) ) -RRB- cord-261417-4pf5nsw2 157 46 transacting transacting NN cord-261417-4pf5nsw2 157 47 guides guide VBZ cord-261417-4pf5nsw2 157 48 for for IN cord-261417-4pf5nsw2 157 49 interacting interact VBG cord-261417-4pf5nsw2 157 50 TFs tf NNS cord-261417-4pf5nsw2 157 51 by by IN cord-261417-4pf5nsw2 157 52 base base NN cord-261417-4pf5nsw2 157 53 - - HYPH cord-261417-4pf5nsw2 157 54 pairing pair VBG cord-261417-4pf5nsw2 157 55 with with IN cord-261417-4pf5nsw2 157 56 DNA DNA NNP cord-261417-4pf5nsw2 157 57 or or CC cord-261417-4pf5nsw2 157 58 RNA RNA NNP cord-261417-4pf5nsw2 157 59 in in IN cord-261417-4pf5nsw2 157 60 the the DT cord-261417-4pf5nsw2 157 61 vicinity vicinity NN cord-261417-4pf5nsw2 157 62 of of IN cord-261417-4pf5nsw2 157 63 their -PRON- PRP$ cord-261417-4pf5nsw2 157 64 target target NN cord-261417-4pf5nsw2 157 65 sites site NNS cord-261417-4pf5nsw2 157 66 [ [ -LRB- cord-261417-4pf5nsw2 157 67 75 75 CD cord-261417-4pf5nsw2 157 68 ] ] -RRB- cord-261417-4pf5nsw2 157 69 . . . cord-261417-4pf5nsw2 158 1 The the DT cord-261417-4pf5nsw2 158 2 best well RBS cord-261417-4pf5nsw2 158 3 - - HYPH cord-261417-4pf5nsw2 158 4 studied study VBN cord-261417-4pf5nsw2 158 5 case case NN cord-261417-4pf5nsw2 158 6 of of IN cord-261417-4pf5nsw2 158 7 a a DT cord-261417-4pf5nsw2 158 8 TF TF NNP cord-261417-4pf5nsw2 158 9 - - HYPH cord-261417-4pf5nsw2 158 10 recruiting recruit VBG cord-261417-4pf5nsw2 158 11 RNA RNA NNP cord-261417-4pf5nsw2 158 12 scaffold scaffold NN cord-261417-4pf5nsw2 158 13 formed form VBN cord-261417-4pf5nsw2 158 14 by by IN cord-261417-4pf5nsw2 158 15 promoter promoter NN cord-261417-4pf5nsw2 158 16 - - HYPH cord-261417-4pf5nsw2 158 17 proximal proximal JJ cord-261417-4pf5nsw2 158 18 pausing pausing NN cord-261417-4pf5nsw2 158 19 is be VBZ cord-261417-4pf5nsw2 158 20 the the DT cord-261417-4pf5nsw2 158 21 human human JJ cord-261417-4pf5nsw2 158 22 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 158 23 virus virus NN cord-261417-4pf5nsw2 158 24 type type NN cord-261417-4pf5nsw2 158 25 1 1 CD cord-261417-4pf5nsw2 159 1 ( ( -LRB- cord-261417-4pf5nsw2 159 2 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 159 3 ) ) -RRB- cord-261417-4pf5nsw2 159 4 trans trans JJ cord-261417-4pf5nsw2 159 5 - - JJ cord-261417-4pf5nsw2 159 6 acting acting JJ cord-261417-4pf5nsw2 159 7 region region NN cord-261417-4pf5nsw2 159 8 ( ( -LRB- cord-261417-4pf5nsw2 159 9 TAR tar NN cord-261417-4pf5nsw2 159 10 ; ; : cord-261417-4pf5nsw2 159 11 Figure figure NN cord-261417-4pf5nsw2 159 12 3A 3a CD cord-261417-4pf5nsw2 159 13 ) ) -RRB- cord-261417-4pf5nsw2 160 1 [ [ -LRB- cord-261417-4pf5nsw2 160 2 76 76 CD cord-261417-4pf5nsw2 160 3 ] ] -RRB- cord-261417-4pf5nsw2 160 4 . . . cord-261417-4pf5nsw2 161 1 As as IN cord-261417-4pf5nsw2 161 2 a a DT cord-261417-4pf5nsw2 161 3 retrovirus retrovirus NN cord-261417-4pf5nsw2 161 4 , , , cord-261417-4pf5nsw2 161 5 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 161 6 contains contain VBZ cord-261417-4pf5nsw2 161 7 an an DT cord-261417-4pf5nsw2 161 8 RNA RNA NNP cord-261417-4pf5nsw2 161 9 genome genome NN cord-261417-4pf5nsw2 161 10 that that WDT cord-261417-4pf5nsw2 161 11 is be VBZ cord-261417-4pf5nsw2 161 12 reverse reverse JJ cord-261417-4pf5nsw2 161 13 transcribed transcribe VBN cord-261417-4pf5nsw2 161 14 into into IN cord-261417-4pf5nsw2 161 15 DNA dna NN cord-261417-4pf5nsw2 161 16 upon upon IN cord-261417-4pf5nsw2 161 17 entry entry NN cord-261417-4pf5nsw2 161 18 of of IN cord-261417-4pf5nsw2 161 19 the the DT cord-261417-4pf5nsw2 161 20 host host NN cord-261417-4pf5nsw2 161 21 cell cell NN cord-261417-4pf5nsw2 161 22 . . . cord-261417-4pf5nsw2 162 1 This this DT cord-261417-4pf5nsw2 162 2 DNA dna NN cord-261417-4pf5nsw2 162 3 integrates integrate VBZ cord-261417-4pf5nsw2 162 4 into into IN cord-261417-4pf5nsw2 162 5 the the DT cord-261417-4pf5nsw2 162 6 host host NN cord-261417-4pf5nsw2 162 7 genome genome NN cord-261417-4pf5nsw2 162 8 as as IN cord-261417-4pf5nsw2 162 9 a a DT cord-261417-4pf5nsw2 162 10 provirus provirus NN cord-261417-4pf5nsw2 162 11 where where WRB cord-261417-4pf5nsw2 162 12 it -PRON- PRP cord-261417-4pf5nsw2 162 13 can can MD cord-261417-4pf5nsw2 162 14 be be VB cord-261417-4pf5nsw2 162 15 actively actively RB cord-261417-4pf5nsw2 162 16 transcribed transcribe VBN cord-261417-4pf5nsw2 162 17 or or CC cord-261417-4pf5nsw2 162 18 enter enter VB cord-261417-4pf5nsw2 162 19 a a DT cord-261417-4pf5nsw2 162 20 latent latent JJ cord-261417-4pf5nsw2 162 21 state state NN cord-261417-4pf5nsw2 162 22 . . . cord-261417-4pf5nsw2 163 1 As as IN cord-261417-4pf5nsw2 163 2 in in IN cord-261417-4pf5nsw2 163 3 all all DT cord-261417-4pf5nsw2 163 4 retroviruses retrovirus NNS cord-261417-4pf5nsw2 163 5 , , , cord-261417-4pf5nsw2 163 6 the the DT cord-261417-4pf5nsw2 163 7 5 5 CD cord-261417-4pf5nsw2 163 8 located locate VBN cord-261417-4pf5nsw2 163 9 long long JJ cord-261417-4pf5nsw2 163 10 terminal terminal NN cord-261417-4pf5nsw2 163 11 repeat repeat NN cord-261417-4pf5nsw2 163 12 will will MD cord-261417-4pf5nsw2 163 13 act act VB cord-261417-4pf5nsw2 163 14 as as IN cord-261417-4pf5nsw2 163 15 the the DT cord-261417-4pf5nsw2 163 16 viral viral JJ cord-261417-4pf5nsw2 163 17 promoter promoter NN cord-261417-4pf5nsw2 163 18 . . . cord-261417-4pf5nsw2 164 1 The the DT cord-261417-4pf5nsw2 164 2 viral viral JJ cord-261417-4pf5nsw2 164 3 promoter promoter NN cord-261417-4pf5nsw2 164 4 can can MD cord-261417-4pf5nsw2 164 5 be be VB cord-261417-4pf5nsw2 164 6 subdivided subdivide VBN cord-261417-4pf5nsw2 164 7 into into IN cord-261417-4pf5nsw2 164 8 the the DT cord-261417-4pf5nsw2 164 9 enhancer enhancer NN cord-261417-4pf5nsw2 164 10 and and CC cord-261417-4pf5nsw2 164 11 core core NN cord-261417-4pf5nsw2 164 12 regions region NNS cord-261417-4pf5nsw2 164 13 . . . cord-261417-4pf5nsw2 165 1 The the DT cord-261417-4pf5nsw2 165 2 enhancer enhancer NN cord-261417-4pf5nsw2 165 3 region region NN cord-261417-4pf5nsw2 165 4 contains contain VBZ cord-261417-4pf5nsw2 165 5 binding bind VBG cord-261417-4pf5nsw2 165 6 sites site NNS cord-261417-4pf5nsw2 165 7 for for IN cord-261417-4pf5nsw2 165 8 NF nf NN cord-261417-4pf5nsw2 165 9 - - HYPH cord-261417-4pf5nsw2 165 10 κB κB NNP cord-261417-4pf5nsw2 165 11 [ [ -LRB- cord-261417-4pf5nsw2 165 12 77 77 CD cord-261417-4pf5nsw2 165 13 , , , cord-261417-4pf5nsw2 165 14 78 78 CD cord-261417-4pf5nsw2 165 15 ] ] -RRB- cord-261417-4pf5nsw2 165 16 , , , cord-261417-4pf5nsw2 165 17 nuclear nuclear JJ cord-261417-4pf5nsw2 165 18 factor factor NN cord-261417-4pf5nsw2 165 19 of of IN cord-261417-4pf5nsw2 165 20 activated activate VBN cord-261417-4pf5nsw2 165 21 T T NNP cord-261417-4pf5nsw2 165 22 - - HYPH cord-261417-4pf5nsw2 165 23 cells cell NNS cord-261417-4pf5nsw2 165 24 ( ( -LRB- cord-261417-4pf5nsw2 165 25 NFAT NFAT NNP cord-261417-4pf5nsw2 165 26 ) ) -RRB- cord-261417-4pf5nsw2 165 27 [ [ -LRB- cord-261417-4pf5nsw2 165 28 79 79 CD cord-261417-4pf5nsw2 165 29 ] ] -RRB- cord-261417-4pf5nsw2 165 30 , , , cord-261417-4pf5nsw2 165 31 activator activator NN cord-261417-4pf5nsw2 165 32 protein protein NN cord-261417-4pf5nsw2 165 33 1 1 CD cord-261417-4pf5nsw2 165 34 ( ( -LRB- cord-261417-4pf5nsw2 165 35 AP1 AP1 NNP cord-261417-4pf5nsw2 165 36 ) ) -RRB- cord-261417-4pf5nsw2 165 37 [ [ -LRB- cord-261417-4pf5nsw2 165 38 80 80 CD cord-261417-4pf5nsw2 165 39 , , , cord-261417-4pf5nsw2 165 40 81 81 CD cord-261417-4pf5nsw2 165 41 ] ] -RRB- cord-261417-4pf5nsw2 165 42 and and CC cord-261417-4pf5nsw2 165 43 variable variable JJ cord-261417-4pf5nsw2 165 44 other other JJ cord-261417-4pf5nsw2 165 45 TFs tf NNS cord-261417-4pf5nsw2 165 46 dependent dependent JJ cord-261417-4pf5nsw2 165 47 on on IN cord-261417-4pf5nsw2 165 48 the the DT cord-261417-4pf5nsw2 165 49 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 165 50 subtype subtype NN cord-261417-4pf5nsw2 165 51 [ [ -LRB- cord-261417-4pf5nsw2 165 52 82 82 CD cord-261417-4pf5nsw2 165 53 ] ] -RRB- cord-261417-4pf5nsw2 165 54 . . . cord-261417-4pf5nsw2 166 1 This this DT cord-261417-4pf5nsw2 166 2 enhancer enhancer NN cord-261417-4pf5nsw2 166 3 upregulates upregulate VBZ cord-261417-4pf5nsw2 166 4 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 166 5 transcription transcription NN cord-261417-4pf5nsw2 166 6 , , , cord-261417-4pf5nsw2 166 7 but but CC cord-261417-4pf5nsw2 166 8 removal removal NN cord-261417-4pf5nsw2 166 9 of of IN cord-261417-4pf5nsw2 166 10 its -PRON- PRP$ cord-261417-4pf5nsw2 166 11 binding binding NN cord-261417-4pf5nsw2 166 12 sites site NNS cord-261417-4pf5nsw2 166 13 is be VBZ cord-261417-4pf5nsw2 166 14 not not RB cord-261417-4pf5nsw2 166 15 deleterious deleterious JJ cord-261417-4pf5nsw2 166 16 in in IN cord-261417-4pf5nsw2 166 17 certain certain JJ cord-261417-4pf5nsw2 166 18 cell cell NN cord-261417-4pf5nsw2 166 19 lines line NNS cord-261417-4pf5nsw2 166 20 [ [ -LRB- cord-261417-4pf5nsw2 166 21 83 83 CD cord-261417-4pf5nsw2 166 22 ] ] -RRB- cord-261417-4pf5nsw2 166 23 . . . cord-261417-4pf5nsw2 167 1 In in IN cord-261417-4pf5nsw2 167 2 contrast contrast NN cord-261417-4pf5nsw2 167 3 , , , cord-261417-4pf5nsw2 167 4 the the DT cord-261417-4pf5nsw2 167 5 core core NN cord-261417-4pf5nsw2 167 6 promoter promoter NN cord-261417-4pf5nsw2 167 7 is be VBZ cord-261417-4pf5nsw2 167 8 essential essential JJ cord-261417-4pf5nsw2 167 9 for for IN cord-261417-4pf5nsw2 167 10 transcription transcription NN cord-261417-4pf5nsw2 167 11 and and CC cord-261417-4pf5nsw2 167 12 contains contain VBZ cord-261417-4pf5nsw2 167 13 three three CD cord-261417-4pf5nsw2 167 14 binding bind VBG cord-261417-4pf5nsw2 167 15 sites site NNS cord-261417-4pf5nsw2 167 16 for for IN cord-261417-4pf5nsw2 167 17 SP1 SP1 NNP cord-261417-4pf5nsw2 167 18 [ [ -LRB- cord-261417-4pf5nsw2 167 19 84 84 CD cord-261417-4pf5nsw2 167 20 ] ] -RRB- cord-261417-4pf5nsw2 167 21 and and CC cord-261417-4pf5nsw2 167 22 a a DT cord-261417-4pf5nsw2 167 23 TATA TATA NNP cord-261417-4pf5nsw2 167 24 box box NN cord-261417-4pf5nsw2 167 25 ( ( -LRB- cord-261417-4pf5nsw2 167 26 CATATAA CATATAA NNP cord-261417-4pf5nsw2 167 27 ) ) -RRB- cord-261417-4pf5nsw2 167 28 element element NN cord-261417-4pf5nsw2 167 29 [ [ -LRB- cord-261417-4pf5nsw2 167 30 81 81 CD cord-261417-4pf5nsw2 167 31 ] ] -RRB- cord-261417-4pf5nsw2 167 32 . . . cord-261417-4pf5nsw2 168 1 RNAPII RNAPII NNP cord-261417-4pf5nsw2 168 2 , , , cord-261417-4pf5nsw2 168 3 phosphorylated phosphorylate VBN cord-261417-4pf5nsw2 168 4 at at IN cord-261417-4pf5nsw2 168 5 Ser5 Ser5 NNP cord-261417-4pf5nsw2 168 6 by by IN cord-261417-4pf5nsw2 168 7 TFIIH TFIIH NNP cord-261417-4pf5nsw2 168 8 , , , cord-261417-4pf5nsw2 168 9 will will MD cord-261417-4pf5nsw2 168 10 initiate initiate VB cord-261417-4pf5nsw2 168 11 transcription transcription NN cord-261417-4pf5nsw2 168 12 from from IN cord-261417-4pf5nsw2 168 13 this this DT cord-261417-4pf5nsw2 168 14 core core NN cord-261417-4pf5nsw2 168 15 region region NN cord-261417-4pf5nsw2 168 16 [ [ -LRB- cord-261417-4pf5nsw2 168 17 85 85 CD cord-261417-4pf5nsw2 168 18 , , , cord-261417-4pf5nsw2 168 19 86 86 CD cord-261417-4pf5nsw2 168 20 ] ] -RRB- cord-261417-4pf5nsw2 168 21 ( ( -LRB- cord-261417-4pf5nsw2 168 22 Figure figure NN cord-261417-4pf5nsw2 168 23 3B 3b CD cord-261417-4pf5nsw2 168 24 ) ) -RRB- cord-261417-4pf5nsw2 168 25 . . . cord-261417-4pf5nsw2 169 1 However however RB cord-261417-4pf5nsw2 169 2 , , , cord-261417-4pf5nsw2 169 3 most most JJS cord-261417-4pf5nsw2 169 4 RNAPII RNAPII NNP cord-261417-4pf5nsw2 169 5 complexes complex NNS cord-261417-4pf5nsw2 169 6 will will MD cord-261417-4pf5nsw2 169 7 pause pause VB cord-261417-4pf5nsw2 169 8 after after IN cord-261417-4pf5nsw2 169 9 transcribing transcribe VBG cord-261417-4pf5nsw2 169 10 62-nt 62-nt CD cord-261417-4pf5nsw2 169 11 , , , cord-261417-4pf5nsw2 169 12 yielding yield VBG cord-261417-4pf5nsw2 169 13 short short JJ cord-261417-4pf5nsw2 169 14 transcripts transcript NNS cord-261417-4pf5nsw2 169 15 [ [ -LRB- cord-261417-4pf5nsw2 169 16 87 87 CD cord-261417-4pf5nsw2 169 17 , , , cord-261417-4pf5nsw2 169 18 88 88 CD cord-261417-4pf5nsw2 169 19 ] ] -RRB- cord-261417-4pf5nsw2 169 20 . . . cord-261417-4pf5nsw2 170 1 This this DT cord-261417-4pf5nsw2 170 2 is be VBZ cord-261417-4pf5nsw2 170 3 caused cause VBN cord-261417-4pf5nsw2 170 4 by by IN cord-261417-4pf5nsw2 170 5 the the DT cord-261417-4pf5nsw2 170 6 combined combine VBN cord-261417-4pf5nsw2 170 7 action action NN cord-261417-4pf5nsw2 170 8 of of IN cord-261417-4pf5nsw2 170 9 NELFs/5,6-dichloro-1-β nelfs/5,6-dichloro-1-β JJ cord-261417-4pf5nsw2 170 10 - - HYPH cord-261417-4pf5nsw2 170 11 d d NN cord-261417-4pf5nsw2 170 12 - - HYPH cord-261417-4pf5nsw2 170 13 ribofuranosylbenzimidazole ribofuranosylbenzimidazole JJ cord-261417-4pf5nsw2 170 14 ( ( -LRB- cord-261417-4pf5nsw2 170 15 DRB DRB NNP cord-261417-4pf5nsw2 170 16 ) ) -RRB- cord-261417-4pf5nsw2 170 17 sensitivity sensitivity NN cord-261417-4pf5nsw2 170 18 inducing induce VBG cord-261417-4pf5nsw2 170 19 factor factor NN cord-261417-4pf5nsw2 170 20 ( ( -LRB- cord-261417-4pf5nsw2 170 21 DSIF DSIF NNP cord-261417-4pf5nsw2 170 22 ) ) -RRB- cord-261417-4pf5nsw2 171 1 [ [ -LRB- cord-261417-4pf5nsw2 171 2 89 89 CD cord-261417-4pf5nsw2 171 3 , , , cord-261417-4pf5nsw2 171 4 90 90 CD cord-261417-4pf5nsw2 171 5 ] ] -RRB- cord-261417-4pf5nsw2 171 6 , , , cord-261417-4pf5nsw2 171 7 the the DT cord-261417-4pf5nsw2 171 8 local local JJ cord-261417-4pf5nsw2 171 9 RNA RNA NNP cord-261417-4pf5nsw2 171 10 structure structure NN cord-261417-4pf5nsw2 171 11 [ [ -LRB- cord-261417-4pf5nsw2 171 12 88 88 CD cord-261417-4pf5nsw2 171 13 , , , cord-261417-4pf5nsw2 171 14 91 91 CD cord-261417-4pf5nsw2 171 15 ] ] -RRB- cord-261417-4pf5nsw2 171 16 , , , cord-261417-4pf5nsw2 171 17 microprocessor microprocessor NN cord-261417-4pf5nsw2 171 18 [ [ -LRB- cord-261417-4pf5nsw2 171 19 70 70 CD cord-261417-4pf5nsw2 171 20 ] ] -RRB- cord-261417-4pf5nsw2 171 21 and and CC cord-261417-4pf5nsw2 171 22 sequences sequence NNS cord-261417-4pf5nsw2 171 23 within within IN cord-261417-4pf5nsw2 171 24 template template NN cord-261417-4pf5nsw2 171 25 DNA dna NN cord-261417-4pf5nsw2 171 26 that that WDT cord-261417-4pf5nsw2 171 27 promote promote VBP cord-261417-4pf5nsw2 171 28 transcriptional transcriptional JJ cord-261417-4pf5nsw2 171 29 pausing pause VBG cord-261417-4pf5nsw2 171 30 [ [ -LRB- cord-261417-4pf5nsw2 171 31 92 92 CD cord-261417-4pf5nsw2 171 32 ] ] -RRB- cord-261417-4pf5nsw2 171 33 . . . cord-261417-4pf5nsw2 172 1 The the DT cord-261417-4pf5nsw2 172 2 position position NN cord-261417-4pf5nsw2 172 3 of of IN cord-261417-4pf5nsw2 172 4 the the DT cord-261417-4pf5nsw2 172 5 promoter promoter NN cord-261417-4pf5nsw2 172 6 - - HYPH cord-261417-4pf5nsw2 172 7 proximal proximal JJ cord-261417-4pf5nsw2 172 8 paused pause VBD cord-261417-4pf5nsw2 172 9 RNAPII RNAPII NNP cord-261417-4pf5nsw2 172 10 on on IN cord-261417-4pf5nsw2 172 11 the the DT cord-261417-4pf5nsw2 172 12 3 3 CD cord-261417-4pf5nsw2 172 13 end end NN cord-261417-4pf5nsw2 172 14 of of IN cord-261417-4pf5nsw2 172 15 the the DT cord-261417-4pf5nsw2 172 16 short short JJ cord-261417-4pf5nsw2 172 17 transcript transcript NN cord-261417-4pf5nsw2 172 18 allows allow VBZ cord-261417-4pf5nsw2 172 19 the the DT cord-261417-4pf5nsw2 172 20 nascent nascent JJ cord-261417-4pf5nsw2 172 21 TAR tar NN cord-261417-4pf5nsw2 172 22 transcript transcript NN cord-261417-4pf5nsw2 172 23 to to TO cord-261417-4pf5nsw2 172 24 fold fold VB cord-261417-4pf5nsw2 172 25 into into IN cord-261417-4pf5nsw2 172 26 an an DT cord-261417-4pf5nsw2 172 27 initial initial JJ cord-261417-4pf5nsw2 172 28 , , , cord-261417-4pf5nsw2 172 29 semi semi JJ cord-261417-4pf5nsw2 172 30 - - JJ cord-261417-4pf5nsw2 172 31 stable stable JJ cord-261417-4pf5nsw2 172 32 RNA RNA NNP cord-261417-4pf5nsw2 172 33 structure structure NN cord-261417-4pf5nsw2 172 34 [ [ -LRB- cord-261417-4pf5nsw2 172 35 88 88 CD cord-261417-4pf5nsw2 172 36 ] ] -RRB- cord-261417-4pf5nsw2 172 37 ( ( -LRB- cord-261417-4pf5nsw2 172 38 Figure figure NN cord-261417-4pf5nsw2 172 39 3B 3b NN cord-261417-4pf5nsw2 172 40 ; ; : cord-261417-4pf5nsw2 172 41 paused pause VBD cord-261417-4pf5nsw2 172 42 TAR tar NN cord-261417-4pf5nsw2 172 43 ) ) -RRB- cord-261417-4pf5nsw2 172 44 . . . cord-261417-4pf5nsw2 173 1 This this DT cord-261417-4pf5nsw2 173 2 nascent nascent JJ cord-261417-4pf5nsw2 173 3 hairpin hairpin NN cord-261417-4pf5nsw2 173 4 allows allow VBZ cord-261417-4pf5nsw2 173 5 the the DT cord-261417-4pf5nsw2 173 6 initial initial JJ cord-261417-4pf5nsw2 173 7 RNAPII RNAPII NNP cord-261417-4pf5nsw2 173 8 complex complex NN cord-261417-4pf5nsw2 173 9 to to TO cord-261417-4pf5nsw2 173 10 backtrack backtrack VB cord-261417-4pf5nsw2 173 11 [ [ -LRB- cord-261417-4pf5nsw2 173 12 91 91 CD cord-261417-4pf5nsw2 173 13 ] ] -RRB- cord-261417-4pf5nsw2 173 14 , , , cord-261417-4pf5nsw2 173 15 such such JJ cord-261417-4pf5nsw2 173 16 that that IN cord-261417-4pf5nsw2 173 17 the the DT cord-261417-4pf5nsw2 173 18 3 3 CD cord-261417-4pf5nsw2 173 19 end end NN cord-261417-4pf5nsw2 173 20 of of IN cord-261417-4pf5nsw2 173 21 the the DT cord-261417-4pf5nsw2 173 22 nascent nascent JJ cord-261417-4pf5nsw2 173 23 transcript transcript NN cord-261417-4pf5nsw2 173 24 is be VBZ cord-261417-4pf5nsw2 173 25 displaced displace VBN cord-261417-4pf5nsw2 173 26 from from IN cord-261417-4pf5nsw2 173 27 the the DT cord-261417-4pf5nsw2 173 28 RNAPII RNAPII NNP cord-261417-4pf5nsw2 173 29 catalytic catalytic JJ cord-261417-4pf5nsw2 173 30 center center NN cord-261417-4pf5nsw2 173 31 [ [ -LRB- cord-261417-4pf5nsw2 173 32 93 93 CD cord-261417-4pf5nsw2 173 33 ] ] -RRB- cord-261417-4pf5nsw2 173 34 ( ( -LRB- cord-261417-4pf5nsw2 173 35 Figure figure NN cord-261417-4pf5nsw2 173 36 3B 3b CD cord-261417-4pf5nsw2 173 37 ) ) -RRB- cord-261417-4pf5nsw2 173 38 . . . cord-261417-4pf5nsw2 174 1 As as IN cord-261417-4pf5nsw2 174 2 a a DT cord-261417-4pf5nsw2 174 3 result result NN cord-261417-4pf5nsw2 174 4 , , , cord-261417-4pf5nsw2 174 5 RNAPII RNAPII NNP cord-261417-4pf5nsw2 174 6 is be VBZ cord-261417-4pf5nsw2 174 7 paused pause VBN cord-261417-4pf5nsw2 174 8 until until IN cord-261417-4pf5nsw2 174 9 it -PRON- PRP cord-261417-4pf5nsw2 174 10 is be VBZ cord-261417-4pf5nsw2 174 11 reactivated reactivate VBN cord-261417-4pf5nsw2 174 12 , , , cord-261417-4pf5nsw2 174 13 which which WDT cord-261417-4pf5nsw2 174 14 may may MD cord-261417-4pf5nsw2 174 15 include include VB cord-261417-4pf5nsw2 174 16 refolding refolde VBG cord-261417-4pf5nsw2 174 17 into into IN cord-261417-4pf5nsw2 174 18 the the DT cord-261417-4pf5nsw2 174 19 most most RBS cord-261417-4pf5nsw2 174 20 stable stable JJ cord-261417-4pf5nsw2 174 21 TAR tar NN cord-261417-4pf5nsw2 174 22 configuration configuration NN cord-261417-4pf5nsw2 174 23 . . . cord-261417-4pf5nsw2 175 1 The the DT cord-261417-4pf5nsw2 175 2 folding folding NN cord-261417-4pf5nsw2 175 3 of of IN cord-261417-4pf5nsw2 175 4 the the DT cord-261417-4pf5nsw2 175 5 TAR tar NN cord-261417-4pf5nsw2 175 6 hairpin hairpin NN cord-261417-4pf5nsw2 175 7 is be VBZ cord-261417-4pf5nsw2 175 8 key key JJ cord-261417-4pf5nsw2 175 9 to to IN cord-261417-4pf5nsw2 175 10 the the DT cord-261417-4pf5nsw2 175 11 regulation regulation NN cord-261417-4pf5nsw2 175 12 of of IN cord-261417-4pf5nsw2 175 13 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 175 14 transcription transcription NN cord-261417-4pf5nsw2 175 15 [ [ -LRB- cord-261417-4pf5nsw2 175 16 94 94 CD cord-261417-4pf5nsw2 175 17 ] ] -RRB- cord-261417-4pf5nsw2 175 18 as as IN cord-261417-4pf5nsw2 175 19 it -PRON- PRP cord-261417-4pf5nsw2 175 20 is be VBZ cord-261417-4pf5nsw2 175 21 used use VBN cord-261417-4pf5nsw2 175 22 as as IN cord-261417-4pf5nsw2 175 23 a a DT cord-261417-4pf5nsw2 175 24 scaffold scaffold NN cord-261417-4pf5nsw2 175 25 to to TO cord-261417-4pf5nsw2 175 26 recruit recruit VB cord-261417-4pf5nsw2 175 27 essential essential JJ cord-261417-4pf5nsw2 175 28 transcription transcription NN cord-261417-4pf5nsw2 175 29 factors factor NNS cord-261417-4pf5nsw2 175 30 , , , cord-261417-4pf5nsw2 175 31 including include VBG cord-261417-4pf5nsw2 175 32 the the DT cord-261417-4pf5nsw2 175 33 86 86 CD cord-261417-4pf5nsw2 175 34 - - SYM cord-261417-4pf5nsw2 175 35 101 101 CD cord-261417-4pf5nsw2 175 36 amino amino NN cord-261417-4pf5nsw2 175 37 acid acid NN cord-261417-4pf5nsw2 175 38 ( ( -LRB- cord-261417-4pf5nsw2 175 39 aa aa NNP cord-261417-4pf5nsw2 175 40 ) ) -RRB- cord-261417-4pf5nsw2 175 41 viral viral JJ cord-261417-4pf5nsw2 175 42 trans trans JJ cord-261417-4pf5nsw2 175 43 - - JJ cord-261417-4pf5nsw2 175 44 activator activator NN cord-261417-4pf5nsw2 175 45 protein protein NN cord-261417-4pf5nsw2 175 46 ( ( -LRB- cord-261417-4pf5nsw2 175 47 Tat tat NN cord-261417-4pf5nsw2 175 48 ) ) -RRB- cord-261417-4pf5nsw2 175 49 [ [ -LRB- cord-261417-4pf5nsw2 175 50 83 83 CD cord-261417-4pf5nsw2 175 51 ] ] -RRB- cord-261417-4pf5nsw2 175 52 ( ( -LRB- cord-261417-4pf5nsw2 175 53 Figure figure NN cord-261417-4pf5nsw2 175 54 3C 3c NN cord-261417-4pf5nsw2 175 55 ) ) -RRB- cord-261417-4pf5nsw2 175 56 . . . cord-261417-4pf5nsw2 176 1 The the DT cord-261417-4pf5nsw2 176 2 interaction interaction NN cord-261417-4pf5nsw2 176 3 between between IN cord-261417-4pf5nsw2 176 4 Tat Tat NNP cord-261417-4pf5nsw2 176 5 and and CC cord-261417-4pf5nsw2 176 6 TAR tar NN cord-261417-4pf5nsw2 176 7 is be VBZ cord-261417-4pf5nsw2 176 8 necessary necessary JJ cord-261417-4pf5nsw2 176 9 to to TO cord-261417-4pf5nsw2 176 10 recruit recruit VB cord-261417-4pf5nsw2 176 11 positive positive JJ cord-261417-4pf5nsw2 176 12 transcription transcription NN cord-261417-4pf5nsw2 176 13 elongation elongation NN cord-261417-4pf5nsw2 176 14 factor factor NN cord-261417-4pf5nsw2 176 15 b b NN cord-261417-4pf5nsw2 176 16 ( ( -LRB- cord-261417-4pf5nsw2 176 17 P p NN cord-261417-4pf5nsw2 176 18 - - HYPH cord-261417-4pf5nsw2 176 19 TEFb TEFb NNS cord-261417-4pf5nsw2 176 20 ) ) -RRB- cord-261417-4pf5nsw2 176 21 from from IN cord-261417-4pf5nsw2 176 22 the the DT cord-261417-4pf5nsw2 176 23 7SK 7sk CD cord-261417-4pf5nsw2 176 24 small small JJ cord-261417-4pf5nsw2 176 25 nuclear nuclear JJ cord-261417-4pf5nsw2 176 26 ribonucleoprotein ribonucleoprotein NN cord-261417-4pf5nsw2 176 27 ( ( -LRB- cord-261417-4pf5nsw2 176 28 snRNP snrnp NN cord-261417-4pf5nsw2 176 29 ) ) -RRB- cord-261417-4pf5nsw2 176 30 [ [ -LRB- cord-261417-4pf5nsw2 176 31 95 95 CD cord-261417-4pf5nsw2 176 32 ] ] -RRB- cord-261417-4pf5nsw2 176 33 . . . cord-261417-4pf5nsw2 177 1 P p NN cord-261417-4pf5nsw2 177 2 - - HYPH cord-261417-4pf5nsw2 177 3 TEFb TEFb NNS cord-261417-4pf5nsw2 177 4 consists consist VBZ cord-261417-4pf5nsw2 177 5 of of IN cord-261417-4pf5nsw2 177 6 CyclinT1 CyclinT1 . cord-261417-4pf5nsw2 178 1 ( ( -LRB- cord-261417-4pf5nsw2 178 2 CycT1 CycT1 NNP cord-261417-4pf5nsw2 178 3 ; ; : cord-261417-4pf5nsw2 178 4 Figure figure NN cord-261417-4pf5nsw2 178 5 3C 3c NN cord-261417-4pf5nsw2 178 6 ) ) -RRB- cord-261417-4pf5nsw2 178 7 tightly tightly RB cord-261417-4pf5nsw2 178 8 associated associate VBN cord-261417-4pf5nsw2 178 9 with with IN cord-261417-4pf5nsw2 178 10 CDK9 CDK9 NNP cord-261417-4pf5nsw2 178 11 kinase kinase NN cord-261417-4pf5nsw2 178 12 and and CC cord-261417-4pf5nsw2 178 13 is be VBZ cord-261417-4pf5nsw2 178 14 sequestered sequester VBN cord-261417-4pf5nsw2 178 15 in in IN cord-261417-4pf5nsw2 178 16 an an DT cord-261417-4pf5nsw2 178 17 inactive inactive JJ cord-261417-4pf5nsw2 178 18 form form NN cord-261417-4pf5nsw2 178 19 by by IN cord-261417-4pf5nsw2 178 20 the the DT cord-261417-4pf5nsw2 178 21 7SK 7SK NNP cord-261417-4pf5nsw2 178 22 snRNP snrnp NN cord-261417-4pf5nsw2 178 23 . . . cord-261417-4pf5nsw2 179 1 Tat tat NN cord-261417-4pf5nsw2 179 2 recruits recruit VBZ cord-261417-4pf5nsw2 179 3 P p NN cord-261417-4pf5nsw2 179 4 - - HYPH cord-261417-4pf5nsw2 179 5 TEFb TEFb NNS cord-261417-4pf5nsw2 179 6 by by IN cord-261417-4pf5nsw2 179 7 outcompeting outcompete VBG cord-261417-4pf5nsw2 179 8 the the DT cord-261417-4pf5nsw2 179 9 7SK 7sk CD cord-261417-4pf5nsw2 179 10 snRNP snrnp NN cord-261417-4pf5nsw2 179 11 in in IN cord-261417-4pf5nsw2 179 12 several several JJ cord-261417-4pf5nsw2 179 13 ways way NNS cord-261417-4pf5nsw2 179 14 . . . cord-261417-4pf5nsw2 180 1 First first RB cord-261417-4pf5nsw2 180 2 , , , cord-261417-4pf5nsw2 180 3 the the DT cord-261417-4pf5nsw2 180 4 TAR tar NN cord-261417-4pf5nsw2 180 5 - - HYPH cord-261417-4pf5nsw2 180 6 binding bind VBG cord-261417-4pf5nsw2 180 7 Arginine arginine NN cord-261417-4pf5nsw2 180 8 - - HYPH cord-261417-4pf5nsw2 180 9 rich rich JJ cord-261417-4pf5nsw2 180 10 motif motif NN cord-261417-4pf5nsw2 180 11 ( ( -LRB- cord-261417-4pf5nsw2 180 12 ARM arm NN cord-261417-4pf5nsw2 180 13 ) ) -RRB- cord-261417-4pf5nsw2 180 14 region region NN cord-261417-4pf5nsw2 180 15 of of IN cord-261417-4pf5nsw2 180 16 Tat Tat NNP cord-261417-4pf5nsw2 180 17 ( ( -LRB- cord-261417-4pf5nsw2 180 18 Figure Figure NNP cord-261417-4pf5nsw2 180 19 3C 3c NN cord-261417-4pf5nsw2 180 20 ; ; : cord-261417-4pf5nsw2 180 21 aa aa NNP cord-261417-4pf5nsw2 180 22 [ [ -LRB- cord-261417-4pf5nsw2 180 23 48 48 CD cord-261417-4pf5nsw2 180 24 ] ] -RRB- cord-261417-4pf5nsw2 180 25 [ [ -LRB- cord-261417-4pf5nsw2 180 26 49 49 CD cord-261417-4pf5nsw2 180 27 ] ] -RRB- cord-261417-4pf5nsw2 180 28 [ [ -LRB- cord-261417-4pf5nsw2 180 29 50 50 CD cord-261417-4pf5nsw2 180 30 ] ] -RRB- cord-261417-4pf5nsw2 180 31 [ [ -LRB- cord-261417-4pf5nsw2 180 32 51 51 CD cord-261417-4pf5nsw2 180 33 ] ] -RRB- cord-261417-4pf5nsw2 180 34 [ [ -LRB- cord-261417-4pf5nsw2 180 35 52 52 CD cord-261417-4pf5nsw2 180 36 ] ] -RRB- cord-261417-4pf5nsw2 180 37 [ [ -LRB- cord-261417-4pf5nsw2 180 38 53 53 CD cord-261417-4pf5nsw2 180 39 ] ] -RRB- cord-261417-4pf5nsw2 180 40 [ [ -LRB- cord-261417-4pf5nsw2 180 41 54 54 CD cord-261417-4pf5nsw2 180 42 ] ] -RRB- cord-261417-4pf5nsw2 180 43 [ [ -LRB- cord-261417-4pf5nsw2 180 44 55 55 CD cord-261417-4pf5nsw2 180 45 ] ] -RRB- cord-261417-4pf5nsw2 180 46 [ [ -LRB- cord-261417-4pf5nsw2 180 47 56 56 CD cord-261417-4pf5nsw2 180 48 ] ] -RRB- cord-261417-4pf5nsw2 180 49 [ [ -LRB- cord-261417-4pf5nsw2 180 50 57 57 CD cord-261417-4pf5nsw2 180 51 ] ] -RRB- cord-261417-4pf5nsw2 180 52 shows show VBZ cord-261417-4pf5nsw2 180 53 high high JJ cord-261417-4pf5nsw2 180 54 similarity similarity NN cord-261417-4pf5nsw2 180 55 to to IN cord-261417-4pf5nsw2 180 56 the the DT cord-261417-4pf5nsw2 180 57 7SK 7SK NNP cord-261417-4pf5nsw2 180 58 - - HYPH cord-261417-4pf5nsw2 180 59 binding binding NN cord-261417-4pf5nsw2 180 60 of of IN cord-261417-4pf5nsw2 180 61 7SK 7sk CD cord-261417-4pf5nsw2 180 62 snRNP snrnp NN cord-261417-4pf5nsw2 181 1 component component NNP cord-261417-4pf5nsw2 181 2 hexamethylene hexamethylene NNP cord-261417-4pf5nsw2 181 3 bisacetamide bisacetamide NNP cord-261417-4pf5nsw2 181 4 - - HYPH cord-261417-4pf5nsw2 181 5 induced induce VBN cord-261417-4pf5nsw2 181 6 protein protein NN cord-261417-4pf5nsw2 181 7 1 1 CD cord-261417-4pf5nsw2 181 8 ( ( -LRB- cord-261417-4pf5nsw2 181 9 HEXIM1 HEXIM1 NNP cord-261417-4pf5nsw2 181 10 ) ) -RRB- cord-261417-4pf5nsw2 182 1 [ [ -LRB- cord-261417-4pf5nsw2 182 2 96 96 CD cord-261417-4pf5nsw2 182 3 ] ] -RRB- cord-261417-4pf5nsw2 182 4 . . . cord-261417-4pf5nsw2 183 1 Second second RB cord-261417-4pf5nsw2 183 2 , , , cord-261417-4pf5nsw2 183 3 the the DT cord-261417-4pf5nsw2 183 4 HEXIM1-bound HEXIM1-bound NNP cord-261417-4pf5nsw2 183 5 7SK 7sk CD cord-261417-4pf5nsw2 183 6 stem stem NN cord-261417-4pf5nsw2 183 7 - - HYPH cord-261417-4pf5nsw2 183 8 loop loop NN cord-261417-4pf5nsw2 183 9 1 1 CD cord-261417-4pf5nsw2 183 10 ( ( -LRB- cord-261417-4pf5nsw2 183 11 SL1 SL1 NNP cord-261417-4pf5nsw2 183 12 ) ) -RRB- cord-261417-4pf5nsw2 183 13 is be VBZ cord-261417-4pf5nsw2 183 14 highly highly RB cord-261417-4pf5nsw2 183 15 similar similar JJ cord-261417-4pf5nsw2 183 16 to to IN cord-261417-4pf5nsw2 183 17 the the DT cord-261417-4pf5nsw2 183 18 consensus consensus NN cord-261417-4pf5nsw2 183 19 minimal minimal JJ cord-261417-4pf5nsw2 183 20 structure structure NN cord-261417-4pf5nsw2 183 21 of of IN cord-261417-4pf5nsw2 183 22 the the DT cord-261417-4pf5nsw2 183 23 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 183 24 TAR tar NN cord-261417-4pf5nsw2 183 25 element element NN cord-261417-4pf5nsw2 183 26 [ [ -LRB- cord-261417-4pf5nsw2 183 27 97 97 CD cord-261417-4pf5nsw2 183 28 ] ] -RRB- cord-261417-4pf5nsw2 183 29 , , , cord-261417-4pf5nsw2 183 30 and and CC cord-261417-4pf5nsw2 183 31 third third JJ cord-261417-4pf5nsw2 183 32 , , , cord-261417-4pf5nsw2 183 33 both both CC cord-261417-4pf5nsw2 183 34 Tat Tat NNP cord-261417-4pf5nsw2 183 35 and and CC cord-261417-4pf5nsw2 183 36 HEXIM1 HEXIM1 VBD cord-261417-4pf5nsw2 183 37 bind bind VB cord-261417-4pf5nsw2 183 38 CycT1 CycT1 NNP cord-261417-4pf5nsw2 183 39 in in IN cord-261417-4pf5nsw2 183 40 a a DT cord-261417-4pf5nsw2 183 41 mutually mutually RB cord-261417-4pf5nsw2 183 42 exclusive exclusive JJ cord-261417-4pf5nsw2 183 43 manner manner NN cord-261417-4pf5nsw2 183 44 due due IN cord-261417-4pf5nsw2 183 45 to to IN cord-261417-4pf5nsw2 183 46 the the DT cord-261417-4pf5nsw2 183 47 shared share VBN cord-261417-4pf5nsw2 183 48 CycT1 CycT1 NNP cord-261417-4pf5nsw2 183 49 binding binding NN cord-261417-4pf5nsw2 183 50 site site NN cord-261417-4pf5nsw2 183 51 [ [ -LRB- cord-261417-4pf5nsw2 183 52 98 98 CD cord-261417-4pf5nsw2 183 53 , , , cord-261417-4pf5nsw2 183 54 99 99 CD cord-261417-4pf5nsw2 183 55 ] ] -RRB- cord-261417-4pf5nsw2 183 56 . . . cord-261417-4pf5nsw2 184 1 However however RB cord-261417-4pf5nsw2 184 2 , , , cord-261417-4pf5nsw2 184 3 the the DT cord-261417-4pf5nsw2 184 4 Tat Tat NNP cord-261417-4pf5nsw2 184 5 activation activation NN cord-261417-4pf5nsw2 184 6 domain domain NN cord-261417-4pf5nsw2 184 7 ( ( -LRB- cord-261417-4pf5nsw2 184 8 Figure figure NN cord-261417-4pf5nsw2 184 9 3C 3c NN cord-261417-4pf5nsw2 184 10 ; ; : cord-261417-4pf5nsw2 184 11 AD ad NN cord-261417-4pf5nsw2 184 12 ; ; : cord-261417-4pf5nsw2 184 13 aa aa NNP cord-261417-4pf5nsw2 184 14 1 1 CD cord-261417-4pf5nsw2 184 15 - - SYM cord-261417-4pf5nsw2 184 16 47 47 CD cord-261417-4pf5nsw2 184 17 ) ) -RRB- cord-261417-4pf5nsw2 184 18 has have VBZ cord-261417-4pf5nsw2 184 19 a a DT cord-261417-4pf5nsw2 184 20 10-fold 10-fold JJ cord-261417-4pf5nsw2 184 21 higher high JJR cord-261417-4pf5nsw2 184 22 affinity affinity NN cord-261417-4pf5nsw2 184 23 for for IN cord-261417-4pf5nsw2 184 24 CycT1 CycT1 NNP cord-261417-4pf5nsw2 184 25 [ [ -LRB- cord-261417-4pf5nsw2 184 26 100 100 CD cord-261417-4pf5nsw2 184 27 ] ] -RRB- cord-261417-4pf5nsw2 184 28 . . . cord-261417-4pf5nsw2 185 1 Tat tat NN cord-261417-4pf5nsw2 185 2 will will MD cord-261417-4pf5nsw2 185 3 thus thus RB cord-261417-4pf5nsw2 185 4 bind bind VB cord-261417-4pf5nsw2 185 5 to to IN cord-261417-4pf5nsw2 185 6 7SK 7sk CD cord-261417-4pf5nsw2 185 7 and and CC cord-261417-4pf5nsw2 185 8 CycT1 CycT1 NNP cord-261417-4pf5nsw2 185 9 by by IN cord-261417-4pf5nsw2 185 10 displacing displace VBG cord-261417-4pf5nsw2 185 11 HEXIM1 HEXIM1 VBN cord-261417-4pf5nsw2 186 1 ( ( -LRB- cord-261417-4pf5nsw2 186 2 Figure figure NN cord-261417-4pf5nsw2 186 3 3B 3b CD cord-261417-4pf5nsw2 186 4 ) ) -RRB- cord-261417-4pf5nsw2 187 1 [ [ -LRB- cord-261417-4pf5nsw2 187 2 97 97 CD cord-261417-4pf5nsw2 187 3 ] ] -RRB- cord-261417-4pf5nsw2 187 4 . . . cord-261417-4pf5nsw2 188 1 As as RB cord-261417-4pf5nsw2 188 2 soon soon RB cord-261417-4pf5nsw2 188 3 as as IN cord-261417-4pf5nsw2 188 4 TAR tar NN cord-261417-4pf5nsw2 188 5 forms form NNS cord-261417-4pf5nsw2 188 6 in in IN cord-261417-4pf5nsw2 188 7 the the DT cord-261417-4pf5nsw2 188 8 nascent nascent JJ cord-261417-4pf5nsw2 188 9 viral viral JJ cord-261417-4pf5nsw2 188 10 transcript transcript NN cord-261417-4pf5nsw2 188 11 emerging emerge VBG cord-261417-4pf5nsw2 188 12 from from IN cord-261417-4pf5nsw2 188 13 RNAPII RNAPII NNP cord-261417-4pf5nsw2 188 14 , , , cord-261417-4pf5nsw2 188 15 the the DT cord-261417-4pf5nsw2 188 16 Tat tat NN cord-261417-4pf5nsw2 188 17 : : : cord-261417-4pf5nsw2 189 1 P p NN cord-261417-4pf5nsw2 189 2 - - HYPH cord-261417-4pf5nsw2 189 3 TEFb TEFb NNS cord-261417-4pf5nsw2 189 4 complex complex NN cord-261417-4pf5nsw2 189 5 will will MD cord-261417-4pf5nsw2 189 6 bind bind VB cord-261417-4pf5nsw2 189 7 to to IN cord-261417-4pf5nsw2 189 8 TAR tar NN cord-261417-4pf5nsw2 189 9 , , , cord-261417-4pf5nsw2 189 10 resulting result VBG cord-261417-4pf5nsw2 189 11 in in IN cord-261417-4pf5nsw2 189 12 the the DT cord-261417-4pf5nsw2 189 13 release release NN cord-261417-4pf5nsw2 189 14 of of IN cord-261417-4pf5nsw2 189 15 the the DT cord-261417-4pf5nsw2 189 16 inhibitory inhibitory JJ cord-261417-4pf5nsw2 189 17 7SK 7sk CD cord-261417-4pf5nsw2 189 18 snRNP snrnp NN cord-261417-4pf5nsw2 189 19 . . . cord-261417-4pf5nsw2 190 1 This this DT cord-261417-4pf5nsw2 190 2 activates activate VBZ cord-261417-4pf5nsw2 190 3 P p NN cord-261417-4pf5nsw2 190 4 - - HYPH cord-261417-4pf5nsw2 190 5 TEFb TEFb NNS cord-261417-4pf5nsw2 190 6 , , , cord-261417-4pf5nsw2 190 7 allowing allow VBG cord-261417-4pf5nsw2 190 8 it -PRON- PRP cord-261417-4pf5nsw2 190 9 to to TO cord-261417-4pf5nsw2 190 10 phosphorylate phosphorylate VB cord-261417-4pf5nsw2 190 11 NELF NELF NNP cord-261417-4pf5nsw2 190 12 , , , cord-261417-4pf5nsw2 190 13 DSIF DSIF NNP cord-261417-4pf5nsw2 190 14 , , , cord-261417-4pf5nsw2 190 15 and and CC cord-261417-4pf5nsw2 190 16 Ser2 Ser2 NNP cord-261417-4pf5nsw2 190 17 on on IN cord-261417-4pf5nsw2 190 18 the the DT cord-261417-4pf5nsw2 190 19 RNAPII RNAPII NNP cord-261417-4pf5nsw2 190 20 CTD CTD NNP cord-261417-4pf5nsw2 190 21 , , , cord-261417-4pf5nsw2 190 22 thus thus RB cord-261417-4pf5nsw2 190 23 flipping flip VBG cord-261417-4pf5nsw2 190 24 the the DT cord-261417-4pf5nsw2 190 25 switch switch NN cord-261417-4pf5nsw2 190 26 between between IN cord-261417-4pf5nsw2 190 27 RNAPII RNAPII NNP cord-261417-4pf5nsw2 190 28 pausing pausing NN cord-261417-4pf5nsw2 190 29 and and CC cord-261417-4pf5nsw2 190 30 elongation elongation NN cord-261417-4pf5nsw2 190 31 [ [ -LRB- cord-261417-4pf5nsw2 190 32 95 95 CD cord-261417-4pf5nsw2 190 33 ] ] -RRB- cord-261417-4pf5nsw2 190 34 . . . cord-261417-4pf5nsw2 191 1 Interestingly interestingly RB cord-261417-4pf5nsw2 191 2 , , , cord-261417-4pf5nsw2 191 3 the the DT cord-261417-4pf5nsw2 191 4 human human JJ cord-261417-4pf5nsw2 191 5 T T NNP cord-261417-4pf5nsw2 191 6 - - HYPH cord-261417-4pf5nsw2 191 7 lymphotropic lymphotropic NNP cord-261417-4pf5nsw2 191 8 virus virus NN cord-261417-4pf5nsw2 191 9 type type NN cord-261417-4pf5nsw2 191 10 1 1 CD cord-261417-4pf5nsw2 191 11 transcriptional transcriptional JJ cord-261417-4pf5nsw2 191 12 activator activator NN cord-261417-4pf5nsw2 191 13 Tax Tax NNP cord-261417-4pf5nsw2 191 14 also also RB cord-261417-4pf5nsw2 191 15 utilizes utilize VBZ cord-261417-4pf5nsw2 191 16 P p NN cord-261417-4pf5nsw2 191 17 - - HYPH cord-261417-4pf5nsw2 191 18 TEFb TEFb NNS cord-261417-4pf5nsw2 191 19 for for IN cord-261417-4pf5nsw2 191 20 viral viral JJ cord-261417-4pf5nsw2 191 21 transcription transcription NN cord-261417-4pf5nsw2 191 22 and and CC cord-261417-4pf5nsw2 191 23 displaces displace VBZ cord-261417-4pf5nsw2 191 24 P p NN cord-261417-4pf5nsw2 191 25 - - HYPH cord-261417-4pf5nsw2 191 26 TEFb TEFb NNS cord-261417-4pf5nsw2 191 27 from from IN cord-261417-4pf5nsw2 191 28 7SK 7sk CD cord-261417-4pf5nsw2 191 29 snRNP snrnp NN cord-261417-4pf5nsw2 191 30 through through IN cord-261417-4pf5nsw2 191 31 binding bind VBG cord-261417-4pf5nsw2 191 32 CycT1 CycT1 NNP cord-261417-4pf5nsw2 191 33 [ [ -LRB- cord-261417-4pf5nsw2 191 34 101 101 CD cord-261417-4pf5nsw2 191 35 , , , cord-261417-4pf5nsw2 191 36 102 102 CD cord-261417-4pf5nsw2 191 37 ] ] -RRB- cord-261417-4pf5nsw2 191 38 , , , cord-261417-4pf5nsw2 191 39 suggesting suggest VBG cord-261417-4pf5nsw2 191 40 that that IN cord-261417-4pf5nsw2 191 41 P p NN cord-261417-4pf5nsw2 191 42 - - HYPH cord-261417-4pf5nsw2 191 43 TEFb TEFb NNS cord-261417-4pf5nsw2 191 44 liberation liberation NN cord-261417-4pf5nsw2 191 45 from from IN cord-261417-4pf5nsw2 191 46 7SK 7sk CD cord-261417-4pf5nsw2 191 47 snRNP snrnp NN cord-261417-4pf5nsw2 191 48 could could MD cord-261417-4pf5nsw2 191 49 be be VB cord-261417-4pf5nsw2 191 50 a a DT cord-261417-4pf5nsw2 191 51 common common JJ cord-261417-4pf5nsw2 191 52 theme theme NN cord-261417-4pf5nsw2 191 53 developed develop VBN cord-261417-4pf5nsw2 191 54 by by IN cord-261417-4pf5nsw2 191 55 different different JJ cord-261417-4pf5nsw2 191 56 viruses virus NNS cord-261417-4pf5nsw2 191 57 to to TO cord-261417-4pf5nsw2 191 58 support support VB cord-261417-4pf5nsw2 191 59 their -PRON- PRP$ cord-261417-4pf5nsw2 191 60 replication replication NN cord-261417-4pf5nsw2 191 61 in in IN cord-261417-4pf5nsw2 191 62 host host NN cord-261417-4pf5nsw2 191 63 cells cell NNS cord-261417-4pf5nsw2 191 64 . . . cord-261417-4pf5nsw2 192 1 Viruses virus NNS cord-261417-4pf5nsw2 192 2 2017 2017 CD cord-261417-4pf5nsw2 192 3 , , , cord-261417-4pf5nsw2 192 4 9 9 CD cord-261417-4pf5nsw2 192 5 , , , cord-261417-4pf5nsw2 192 6 309 309 CD cord-261417-4pf5nsw2 192 7 8 8 CD cord-261417-4pf5nsw2 192 8 of of IN cord-261417-4pf5nsw2 192 9 17 17 CD cord-261417-4pf5nsw2 192 10 phosphorylate phosphorylate VBP cord-261417-4pf5nsw2 192 11 NELF NELF NNP cord-261417-4pf5nsw2 192 12 , , , cord-261417-4pf5nsw2 192 13 DSIF DSIF NNP cord-261417-4pf5nsw2 192 14 , , , cord-261417-4pf5nsw2 192 15 and and CC cord-261417-4pf5nsw2 192 16 Ser2 Ser2 NNP cord-261417-4pf5nsw2 192 17 on on IN cord-261417-4pf5nsw2 192 18 the the DT cord-261417-4pf5nsw2 192 19 RNAPII RNAPII NNP cord-261417-4pf5nsw2 192 20 CTD CTD NNP cord-261417-4pf5nsw2 192 21 , , , cord-261417-4pf5nsw2 192 22 thus thus RB cord-261417-4pf5nsw2 192 23 flipping flip VBG cord-261417-4pf5nsw2 192 24 the the DT cord-261417-4pf5nsw2 192 25 switch switch NN cord-261417-4pf5nsw2 192 26 between between IN cord-261417-4pf5nsw2 192 27 RNAPII RNAPII NNP cord-261417-4pf5nsw2 192 28 pausing pausing NN cord-261417-4pf5nsw2 192 29 and and CC cord-261417-4pf5nsw2 192 30 elongation elongation NN cord-261417-4pf5nsw2 192 31 [ [ -LRB- cord-261417-4pf5nsw2 192 32 95 95 CD cord-261417-4pf5nsw2 192 33 ] ] -RRB- cord-261417-4pf5nsw2 192 34 . . . cord-261417-4pf5nsw2 193 1 Interestingly interestingly RB cord-261417-4pf5nsw2 193 2 , , , cord-261417-4pf5nsw2 193 3 the the DT cord-261417-4pf5nsw2 193 4 human human JJ cord-261417-4pf5nsw2 193 5 T T NNP cord-261417-4pf5nsw2 193 6 - - HYPH cord-261417-4pf5nsw2 193 7 lymphotropic lymphotropic NNP cord-261417-4pf5nsw2 193 8 virus virus NN cord-261417-4pf5nsw2 193 9 type type NN cord-261417-4pf5nsw2 193 10 1 1 CD cord-261417-4pf5nsw2 193 11 transcriptional transcriptional JJ cord-261417-4pf5nsw2 193 12 activator activator NN cord-261417-4pf5nsw2 193 13 Tax Tax NNP cord-261417-4pf5nsw2 193 14 also also RB cord-261417-4pf5nsw2 193 15 utilizes utilize VBZ cord-261417-4pf5nsw2 193 16 P p NN cord-261417-4pf5nsw2 193 17 - - HYPH cord-261417-4pf5nsw2 193 18 TEFb TEFb NNS cord-261417-4pf5nsw2 193 19 for for IN cord-261417-4pf5nsw2 193 20 viral viral JJ cord-261417-4pf5nsw2 193 21 transcription transcription NN cord-261417-4pf5nsw2 193 22 and and CC cord-261417-4pf5nsw2 193 23 displaces displace VBZ cord-261417-4pf5nsw2 193 24 P p NN cord-261417-4pf5nsw2 193 25 - - HYPH cord-261417-4pf5nsw2 193 26 TEFb TEFb NNS cord-261417-4pf5nsw2 193 27 from from IN cord-261417-4pf5nsw2 193 28 7SK 7sk CD cord-261417-4pf5nsw2 193 29 snRNP snrnp NN cord-261417-4pf5nsw2 193 30 through through IN cord-261417-4pf5nsw2 193 31 binding bind VBG cord-261417-4pf5nsw2 193 32 CycT1 CycT1 NNP cord-261417-4pf5nsw2 193 33 [ [ -LRB- cord-261417-4pf5nsw2 193 34 101 101 CD cord-261417-4pf5nsw2 193 35 , , , cord-261417-4pf5nsw2 193 36 102 102 CD cord-261417-4pf5nsw2 193 37 ] ] -RRB- cord-261417-4pf5nsw2 193 38 , , , cord-261417-4pf5nsw2 193 39 suggesting suggest VBG cord-261417-4pf5nsw2 193 40 that that IN cord-261417-4pf5nsw2 193 41 P p NN cord-261417-4pf5nsw2 193 42 - - HYPH cord-261417-4pf5nsw2 193 43 TEFb TEFb NNS cord-261417-4pf5nsw2 193 44 liberation liberation NN cord-261417-4pf5nsw2 193 45 from from IN cord-261417-4pf5nsw2 193 46 7SK 7sk CD cord-261417-4pf5nsw2 193 47 snRNP snrnp NN cord-261417-4pf5nsw2 193 48 could could MD cord-261417-4pf5nsw2 193 49 be be VB cord-261417-4pf5nsw2 193 50 a a DT cord-261417-4pf5nsw2 193 51 common common JJ cord-261417-4pf5nsw2 193 52 theme theme NN cord-261417-4pf5nsw2 193 53 developed develop VBN cord-261417-4pf5nsw2 193 54 by by IN cord-261417-4pf5nsw2 193 55 different different JJ cord-261417-4pf5nsw2 193 56 viruses virus NNS cord-261417-4pf5nsw2 193 57 to to TO cord-261417-4pf5nsw2 193 58 support support VB cord-261417-4pf5nsw2 193 59 their -PRON- PRP$ cord-261417-4pf5nsw2 193 60 replication replication NN cord-261417-4pf5nsw2 193 61 in in IN cord-261417-4pf5nsw2 193 62 host host NN cord-261417-4pf5nsw2 193 63 cells cell NNS cord-261417-4pf5nsw2 193 64 . . . cord-261417-4pf5nsw2 193 65 _SP cord-261417-4pf5nsw2 194 1 Instead instead RB cord-261417-4pf5nsw2 194 2 of of IN cord-261417-4pf5nsw2 194 3 using use VBG cord-261417-4pf5nsw2 194 4 promoter promoter NN cord-261417-4pf5nsw2 194 5 - - HYPH cord-261417-4pf5nsw2 194 6 proximal proximal JJ cord-261417-4pf5nsw2 194 7 paused pause VBN cord-261417-4pf5nsw2 194 8 transcripts transcript NNS cord-261417-4pf5nsw2 194 9 as as IN cord-261417-4pf5nsw2 194 10 cis cis NNP cord-261417-4pf5nsw2 194 11 - - HYPH cord-261417-4pf5nsw2 194 12 acting act VBG cord-261417-4pf5nsw2 194 13 scaffolds scaffold NNS cord-261417-4pf5nsw2 194 14 to to TO cord-261417-4pf5nsw2 194 15 recruit recruit VB cord-261417-4pf5nsw2 194 16 TFs tf NNS cord-261417-4pf5nsw2 194 17 , , , cord-261417-4pf5nsw2 194 18 viruses virus NNS cord-261417-4pf5nsw2 194 19 can can MD cord-261417-4pf5nsw2 194 20 also also RB cord-261417-4pf5nsw2 194 21 use use VB cord-261417-4pf5nsw2 194 22 noncoding noncoding JJ cord-261417-4pf5nsw2 194 23 RNAs rna NNS cord-261417-4pf5nsw2 194 24 . . . cord-261417-4pf5nsw2 195 1 A a DT cord-261417-4pf5nsw2 195 2 recent recent JJ cord-261417-4pf5nsw2 195 3 example example NN cord-261417-4pf5nsw2 195 4 described describe VBD cord-261417-4pf5nsw2 195 5 that that IN cord-261417-4pf5nsw2 195 6 the the DT cord-261417-4pf5nsw2 195 7 Epstein Epstein NNP cord-261417-4pf5nsw2 195 8 - - HYPH cord-261417-4pf5nsw2 195 9 Barr Barr NNP cord-261417-4pf5nsw2 195 10 virus virus NN cord-261417-4pf5nsw2 195 11 ( ( -LRB- cord-261417-4pf5nsw2 195 12 EBV EBV NNP cord-261417-4pf5nsw2 195 13 ) ) -RRB- cord-261417-4pf5nsw2 195 14 uses use VBZ cord-261417-4pf5nsw2 195 15 a a DT cord-261417-4pf5nsw2 195 16 virally virally RB cord-261417-4pf5nsw2 195 17 encoded encode VBN cord-261417-4pf5nsw2 195 18 noncoding noncoding JJ cord-261417-4pf5nsw2 195 19 RNA RNA NNP cord-261417-4pf5nsw2 195 20 named name VBN cord-261417-4pf5nsw2 195 21 EBV EBV NNP cord-261417-4pf5nsw2 195 22 - - HYPH cord-261417-4pf5nsw2 195 23 encoded encode VBN cord-261417-4pf5nsw2 195 24 RNA RNA NNP cord-261417-4pf5nsw2 195 25 2 2 CD cord-261417-4pf5nsw2 195 26 ( ( -LRB- cord-261417-4pf5nsw2 195 27 EBER2 EBER2 NNP cord-261417-4pf5nsw2 195 28 ) ) -RRB- cord-261417-4pf5nsw2 195 29 that that WDT cord-261417-4pf5nsw2 195 30 acts act VBZ cord-261417-4pf5nsw2 195 31 as as IN cord-261417-4pf5nsw2 195 32 a a DT cord-261417-4pf5nsw2 195 33 transacting transacting NN cord-261417-4pf5nsw2 195 34 guide guide NN cord-261417-4pf5nsw2 195 35 to to TO cord-261417-4pf5nsw2 195 36 promote promote VB cord-261417-4pf5nsw2 195 37 its -PRON- PRP$ cord-261417-4pf5nsw2 195 38 own own JJ cord-261417-4pf5nsw2 195 39 transcription transcription NN cord-261417-4pf5nsw2 195 40 [ [ -LRB- cord-261417-4pf5nsw2 195 41 75 75 CD cord-261417-4pf5nsw2 195 42 ] ] -RRB- cord-261417-4pf5nsw2 196 1 ( ( -LRB- cord-261417-4pf5nsw2 196 2 Figure figure NN cord-261417-4pf5nsw2 196 3 4 4 CD cord-261417-4pf5nsw2 196 4 ) ) -RRB- cord-261417-4pf5nsw2 196 5 . . . cord-261417-4pf5nsw2 197 1 EBV EBV NNP cord-261417-4pf5nsw2 197 2 is be VBZ cord-261417-4pf5nsw2 197 3 a a DT cord-261417-4pf5nsw2 197 4 human human JJ cord-261417-4pf5nsw2 197 5 γ γ NN cord-261417-4pf5nsw2 197 6 - - HYPH cord-261417-4pf5nsw2 197 7 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 197 8 that that WDT cord-261417-4pf5nsw2 197 9 persists persist VBZ cord-261417-4pf5nsw2 197 10 as as IN cord-261417-4pf5nsw2 197 11 a a DT cord-261417-4pf5nsw2 197 12 mini mini NN cord-261417-4pf5nsw2 197 13 - - NN cord-261417-4pf5nsw2 197 14 chromosome chromosome NN cord-261417-4pf5nsw2 197 15 in in IN cord-261417-4pf5nsw2 197 16 the the DT cord-261417-4pf5nsw2 197 17 nucleus nucleus NN cord-261417-4pf5nsw2 197 18 of of IN cord-261417-4pf5nsw2 197 19 B b NN cord-261417-4pf5nsw2 197 20 lymphocytes lymphocyte NNS cord-261417-4pf5nsw2 197 21 [ [ -LRB- cord-261417-4pf5nsw2 197 22 103 103 CD cord-261417-4pf5nsw2 197 23 ] ] -RRB- cord-261417-4pf5nsw2 197 24 . . . cord-261417-4pf5nsw2 198 1 Herpesviruses Herpesviruses NNP cord-261417-4pf5nsw2 198 2 are be VBP cord-261417-4pf5nsw2 198 3 large large JJ cord-261417-4pf5nsw2 198 4 enveloped envelop VBN cord-261417-4pf5nsw2 198 5 ds ds NNP cord-261417-4pf5nsw2 198 6 DNA DNA NNP cord-261417-4pf5nsw2 198 7 viruses virus NNS cord-261417-4pf5nsw2 198 8 that that WDT cord-261417-4pf5nsw2 198 9 encode encode VBP cord-261417-4pf5nsw2 198 10 more more JJR cord-261417-4pf5nsw2 198 11 than than IN cord-261417-4pf5nsw2 198 12 80 80 CD cord-261417-4pf5nsw2 198 13 genes gene NNS cord-261417-4pf5nsw2 198 14 . . . cord-261417-4pf5nsw2 199 1 They -PRON- PRP cord-261417-4pf5nsw2 199 2 are be VBP cord-261417-4pf5nsw2 199 3 classified classify VBN cord-261417-4pf5nsw2 199 4 into into IN cord-261417-4pf5nsw2 199 5 three three CD cord-261417-4pf5nsw2 199 6 subfamilies subfamily NNS cord-261417-4pf5nsw2 199 7 ( ( -LRB- cord-261417-4pf5nsw2 199 8 α- α- XX cord-261417-4pf5nsw2 199 9 , , , cord-261417-4pf5nsw2 199 10 β- β- XX cord-261417-4pf5nsw2 199 11 , , , cord-261417-4pf5nsw2 199 12 and and CC cord-261417-4pf5nsw2 199 13 γ γ NN cord-261417-4pf5nsw2 199 14 - - HYPH cord-261417-4pf5nsw2 199 15 herpesviruses herpesviruses NNP cord-261417-4pf5nsw2 199 16 ) ) -RRB- cord-261417-4pf5nsw2 199 17 . . . cord-261417-4pf5nsw2 200 1 EBV EBV NNP cord-261417-4pf5nsw2 200 2 is be VBZ cord-261417-4pf5nsw2 200 3 the the DT cord-261417-4pf5nsw2 200 4 causative causative JJ cord-261417-4pf5nsw2 200 5 agent agent NN cord-261417-4pf5nsw2 200 6 of of IN cord-261417-4pf5nsw2 200 7 mononucleosis mononucleosis NN cord-261417-4pf5nsw2 200 8 and and CC cord-261417-4pf5nsw2 200 9 is be VBZ cord-261417-4pf5nsw2 200 10 associated associate VBN cord-261417-4pf5nsw2 200 11 with with IN cord-261417-4pf5nsw2 200 12 several several JJ cord-261417-4pf5nsw2 200 13 types type NNS cord-261417-4pf5nsw2 200 14 of of IN cord-261417-4pf5nsw2 200 15 tumors tumor NNS cord-261417-4pf5nsw2 200 16 , , , cord-261417-4pf5nsw2 200 17 including include VBG cord-261417-4pf5nsw2 200 18 lymphomas lymphoma NNS cord-261417-4pf5nsw2 200 19 and and CC cord-261417-4pf5nsw2 200 20 carcinomas carcinoma NNS cord-261417-4pf5nsw2 200 21 [ [ -LRB- cord-261417-4pf5nsw2 200 22 104 104 CD cord-261417-4pf5nsw2 200 23 ] ] -RRB- cord-261417-4pf5nsw2 200 24 . . . cord-261417-4pf5nsw2 201 1 Two two CD cord-261417-4pf5nsw2 201 2 long long JJ cord-261417-4pf5nsw2 201 3 ncRNAs ncRNAs NNP cord-261417-4pf5nsw2 201 4 called call VBN cord-261417-4pf5nsw2 201 5 EBER1 eber1 NN cord-261417-4pf5nsw2 201 6 ( ( -LRB- cord-261417-4pf5nsw2 201 7 167 167 CD cord-261417-4pf5nsw2 201 8 nt nt JJ cord-261417-4pf5nsw2 201 9 ) ) -RRB- cord-261417-4pf5nsw2 201 10 and and CC cord-261417-4pf5nsw2 201 11 EBER2 EBER2 NNS cord-261417-4pf5nsw2 201 12 ( ( -LRB- cord-261417-4pf5nsw2 201 13 173 173 CD cord-261417-4pf5nsw2 201 14 nt nt JJ cord-261417-4pf5nsw2 201 15 ) ) -RRB- cord-261417-4pf5nsw2 201 16 are be VBP cord-261417-4pf5nsw2 201 17 expressed express VBN cord-261417-4pf5nsw2 201 18 in in IN cord-261417-4pf5nsw2 201 19 infected infected JJ cord-261417-4pf5nsw2 201 20 cells cell NNS cord-261417-4pf5nsw2 201 21 at at IN cord-261417-4pf5nsw2 201 22 high high JJ cord-261417-4pf5nsw2 201 23 levels level NNS cord-261417-4pf5nsw2 201 24 ( ( -LRB- cord-261417-4pf5nsw2 201 25 EBER1 eber1 RB cord-261417-4pf5nsw2 201 26 : : : cord-261417-4pf5nsw2 201 27 ~10 ~10 NFP cord-261417-4pf5nsw2 201 28 6 6 CD cord-261417-4pf5nsw2 201 29 copies copy NNS cord-261417-4pf5nsw2 201 30 ; ; : cord-261417-4pf5nsw2 201 31 EBER2 EBER2 NNS cord-261417-4pf5nsw2 201 32 : : : cord-261417-4pf5nsw2 202 1 ~2.5 ~2.5 NFP cord-261417-4pf5nsw2 202 2 × × NN cord-261417-4pf5nsw2 202 3 10 10 CD cord-261417-4pf5nsw2 202 4 5 5 CD cord-261417-4pf5nsw2 202 5 ) ) -RRB- cord-261417-4pf5nsw2 203 1 [ [ -LRB- cord-261417-4pf5nsw2 203 2 105 105 CD cord-261417-4pf5nsw2 203 3 , , , cord-261417-4pf5nsw2 203 4 106 106 CD cord-261417-4pf5nsw2 203 5 ] ] -RRB- cord-261417-4pf5nsw2 203 6 and and CC cord-261417-4pf5nsw2 203 7 localize localize VBP cord-261417-4pf5nsw2 203 8 exclusively exclusively RB cord-261417-4pf5nsw2 203 9 to to IN cord-261417-4pf5nsw2 203 10 the the DT cord-261417-4pf5nsw2 203 11 nucleoplasm nucleoplasm NN cord-261417-4pf5nsw2 203 12 [ [ -LRB- cord-261417-4pf5nsw2 203 13 107 107 CD cord-261417-4pf5nsw2 203 14 ] ] -RRB- cord-261417-4pf5nsw2 203 15 . . . cord-261417-4pf5nsw2 204 1 Due due IN cord-261417-4pf5nsw2 204 2 to to IN cord-261417-4pf5nsw2 204 3 their -PRON- PRP$ cord-261417-4pf5nsw2 204 4 high high JJ cord-261417-4pf5nsw2 204 5 copy copy NN cord-261417-4pf5nsw2 204 6 number number NN cord-261417-4pf5nsw2 204 7 , , , cord-261417-4pf5nsw2 204 8 _SP cord-261417-4pf5nsw2 204 9 Instead instead RB cord-261417-4pf5nsw2 204 10 of of IN cord-261417-4pf5nsw2 204 11 using use VBG cord-261417-4pf5nsw2 204 12 promoter promoter NN cord-261417-4pf5nsw2 204 13 - - HYPH cord-261417-4pf5nsw2 204 14 proximal proximal JJ cord-261417-4pf5nsw2 204 15 paused pause VBN cord-261417-4pf5nsw2 204 16 transcripts transcript NNS cord-261417-4pf5nsw2 204 17 as as IN cord-261417-4pf5nsw2 204 18 cis cis NNP cord-261417-4pf5nsw2 204 19 - - HYPH cord-261417-4pf5nsw2 204 20 acting act VBG cord-261417-4pf5nsw2 204 21 scaffolds scaffold NNS cord-261417-4pf5nsw2 204 22 to to TO cord-261417-4pf5nsw2 204 23 recruit recruit VB cord-261417-4pf5nsw2 204 24 TFs tf NNS cord-261417-4pf5nsw2 204 25 , , , cord-261417-4pf5nsw2 204 26 viruses virus NNS cord-261417-4pf5nsw2 204 27 can can MD cord-261417-4pf5nsw2 204 28 also also RB cord-261417-4pf5nsw2 204 29 use use VB cord-261417-4pf5nsw2 204 30 noncoding noncoding JJ cord-261417-4pf5nsw2 204 31 RNAs rna NNS cord-261417-4pf5nsw2 204 32 . . . cord-261417-4pf5nsw2 205 1 A a DT cord-261417-4pf5nsw2 205 2 recent recent JJ cord-261417-4pf5nsw2 205 3 example example NN cord-261417-4pf5nsw2 205 4 described describe VBD cord-261417-4pf5nsw2 205 5 that that IN cord-261417-4pf5nsw2 205 6 the the DT cord-261417-4pf5nsw2 205 7 Epstein Epstein NNP cord-261417-4pf5nsw2 205 8 - - HYPH cord-261417-4pf5nsw2 205 9 Barr Barr NNP cord-261417-4pf5nsw2 205 10 virus virus NN cord-261417-4pf5nsw2 205 11 ( ( -LRB- cord-261417-4pf5nsw2 205 12 EBV EBV NNP cord-261417-4pf5nsw2 205 13 ) ) -RRB- cord-261417-4pf5nsw2 205 14 uses use VBZ cord-261417-4pf5nsw2 205 15 a a DT cord-261417-4pf5nsw2 205 16 virally virally RB cord-261417-4pf5nsw2 205 17 encoded encode VBN cord-261417-4pf5nsw2 205 18 noncoding noncoding JJ cord-261417-4pf5nsw2 205 19 RNA RNA NNP cord-261417-4pf5nsw2 205 20 named name VBN cord-261417-4pf5nsw2 205 21 EBV EBV NNP cord-261417-4pf5nsw2 205 22 - - HYPH cord-261417-4pf5nsw2 205 23 encoded encode VBN cord-261417-4pf5nsw2 205 24 RNA RNA NNP cord-261417-4pf5nsw2 205 25 2 2 CD cord-261417-4pf5nsw2 205 26 ( ( -LRB- cord-261417-4pf5nsw2 205 27 EBER2 EBER2 NNP cord-261417-4pf5nsw2 205 28 ) ) -RRB- cord-261417-4pf5nsw2 205 29 that that WDT cord-261417-4pf5nsw2 205 30 acts act VBZ cord-261417-4pf5nsw2 205 31 as as IN cord-261417-4pf5nsw2 205 32 a a DT cord-261417-4pf5nsw2 205 33 trans trans JJ cord-261417-4pf5nsw2 205 34 - - JJ cord-261417-4pf5nsw2 205 35 acting acting JJ cord-261417-4pf5nsw2 205 36 guide guide NN cord-261417-4pf5nsw2 205 37 to to TO cord-261417-4pf5nsw2 205 38 promote promote VB cord-261417-4pf5nsw2 205 39 its -PRON- PRP$ cord-261417-4pf5nsw2 205 40 own own JJ cord-261417-4pf5nsw2 205 41 transcription transcription NN cord-261417-4pf5nsw2 205 42 [ [ -LRB- cord-261417-4pf5nsw2 205 43 75 75 CD cord-261417-4pf5nsw2 205 44 ] ] -RRB- cord-261417-4pf5nsw2 206 1 ( ( -LRB- cord-261417-4pf5nsw2 206 2 Figure figure NN cord-261417-4pf5nsw2 206 3 4 4 CD cord-261417-4pf5nsw2 206 4 ) ) -RRB- cord-261417-4pf5nsw2 206 5 . . . cord-261417-4pf5nsw2 207 1 EBV EBV NNP cord-261417-4pf5nsw2 207 2 is be VBZ cord-261417-4pf5nsw2 207 3 a a DT cord-261417-4pf5nsw2 207 4 human human JJ cord-261417-4pf5nsw2 207 5 γ γ NN cord-261417-4pf5nsw2 207 6 - - HYPH cord-261417-4pf5nsw2 207 7 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 207 8 that that WDT cord-261417-4pf5nsw2 207 9 persists persist VBZ cord-261417-4pf5nsw2 207 10 as as IN cord-261417-4pf5nsw2 207 11 a a DT cord-261417-4pf5nsw2 207 12 mini mini NN cord-261417-4pf5nsw2 207 13 - - NN cord-261417-4pf5nsw2 207 14 chromosome chromosome NN cord-261417-4pf5nsw2 207 15 in in IN cord-261417-4pf5nsw2 207 16 the the DT cord-261417-4pf5nsw2 207 17 nucleus nucleus NN cord-261417-4pf5nsw2 207 18 of of IN cord-261417-4pf5nsw2 207 19 B b NN cord-261417-4pf5nsw2 207 20 lymphocytes lymphocyte NNS cord-261417-4pf5nsw2 207 21 [ [ -LRB- cord-261417-4pf5nsw2 207 22 103 103 CD cord-261417-4pf5nsw2 207 23 ] ] -RRB- cord-261417-4pf5nsw2 207 24 . . . cord-261417-4pf5nsw2 208 1 Herpesviruses Herpesviruses NNP cord-261417-4pf5nsw2 208 2 are be VBP cord-261417-4pf5nsw2 208 3 large large JJ cord-261417-4pf5nsw2 208 4 enveloped envelop VBN cord-261417-4pf5nsw2 208 5 ds ds NNP cord-261417-4pf5nsw2 208 6 DNA DNA NNP cord-261417-4pf5nsw2 208 7 viruses virus NNS cord-261417-4pf5nsw2 208 8 that that WDT cord-261417-4pf5nsw2 208 9 encode encode VBP cord-261417-4pf5nsw2 208 10 more more JJR cord-261417-4pf5nsw2 208 11 than than IN cord-261417-4pf5nsw2 208 12 80 80 CD cord-261417-4pf5nsw2 208 13 genes gene NNS cord-261417-4pf5nsw2 208 14 . . . cord-261417-4pf5nsw2 209 1 They -PRON- PRP cord-261417-4pf5nsw2 209 2 are be VBP cord-261417-4pf5nsw2 209 3 classified classify VBN cord-261417-4pf5nsw2 209 4 into into IN cord-261417-4pf5nsw2 209 5 three three CD cord-261417-4pf5nsw2 209 6 subfamilies subfamily NNS cord-261417-4pf5nsw2 209 7 ( ( -LRB- cord-261417-4pf5nsw2 209 8 α- α- XX cord-261417-4pf5nsw2 209 9 , , , cord-261417-4pf5nsw2 209 10 β- β- XX cord-261417-4pf5nsw2 209 11 , , , cord-261417-4pf5nsw2 209 12 and and CC cord-261417-4pf5nsw2 209 13 γ γ NN cord-261417-4pf5nsw2 209 14 - - HYPH cord-261417-4pf5nsw2 209 15 herpesviruses herpesviruses NNP cord-261417-4pf5nsw2 209 16 ) ) -RRB- cord-261417-4pf5nsw2 209 17 . . . cord-261417-4pf5nsw2 210 1 EBV EBV NNP cord-261417-4pf5nsw2 210 2 is be VBZ cord-261417-4pf5nsw2 210 3 the the DT cord-261417-4pf5nsw2 210 4 causative causative JJ cord-261417-4pf5nsw2 210 5 agent agent NN cord-261417-4pf5nsw2 210 6 of of IN cord-261417-4pf5nsw2 210 7 mononucleosis mononucleosis NN cord-261417-4pf5nsw2 210 8 and and CC cord-261417-4pf5nsw2 210 9 is be VBZ cord-261417-4pf5nsw2 210 10 associated associate VBN cord-261417-4pf5nsw2 210 11 with with IN cord-261417-4pf5nsw2 210 12 several several JJ cord-261417-4pf5nsw2 210 13 types type NNS cord-261417-4pf5nsw2 210 14 of of IN cord-261417-4pf5nsw2 210 15 tumors tumor NNS cord-261417-4pf5nsw2 210 16 , , , cord-261417-4pf5nsw2 210 17 including include VBG cord-261417-4pf5nsw2 210 18 lymphomas lymphoma NNS cord-261417-4pf5nsw2 210 19 and and CC cord-261417-4pf5nsw2 210 20 carcinomas carcinoma NNS cord-261417-4pf5nsw2 210 21 [ [ -LRB- cord-261417-4pf5nsw2 210 22 104 104 CD cord-261417-4pf5nsw2 210 23 ] ] -RRB- cord-261417-4pf5nsw2 210 24 . . . cord-261417-4pf5nsw2 211 1 Two two CD cord-261417-4pf5nsw2 211 2 long long JJ cord-261417-4pf5nsw2 211 3 ncRNAs ncRNAs NNP cord-261417-4pf5nsw2 211 4 called call VBN cord-261417-4pf5nsw2 211 5 EBER1 eber1 NN cord-261417-4pf5nsw2 211 6 ( ( -LRB- cord-261417-4pf5nsw2 211 7 167 167 CD cord-261417-4pf5nsw2 211 8 nt nt JJ cord-261417-4pf5nsw2 211 9 ) ) -RRB- cord-261417-4pf5nsw2 211 10 and and CC cord-261417-4pf5nsw2 211 11 EBER2 EBER2 NNS cord-261417-4pf5nsw2 211 12 ( ( -LRB- cord-261417-4pf5nsw2 211 13 173 173 CD cord-261417-4pf5nsw2 211 14 nt nt JJ cord-261417-4pf5nsw2 211 15 ) ) -RRB- cord-261417-4pf5nsw2 211 16 are be VBP cord-261417-4pf5nsw2 211 17 expressed express VBN cord-261417-4pf5nsw2 211 18 in in IN cord-261417-4pf5nsw2 211 19 infected infected JJ cord-261417-4pf5nsw2 211 20 cells cell NNS cord-261417-4pf5nsw2 211 21 at at IN cord-261417-4pf5nsw2 211 22 high high JJ cord-261417-4pf5nsw2 211 23 levels level NNS cord-261417-4pf5nsw2 211 24 ( ( -LRB- cord-261417-4pf5nsw2 211 25 EBER1:~10 eber1:~10 RB cord-261417-4pf5nsw2 211 26 6 6 CD cord-261417-4pf5nsw2 211 27 copies copy NNS cord-261417-4pf5nsw2 211 28 ; ; . cord-261417-4pf5nsw2 212 1 EBER2:~2.5 EBER2:~2.5 NNP cord-261417-4pf5nsw2 212 2 × × NNP cord-261417-4pf5nsw2 212 3 10 10 CD cord-261417-4pf5nsw2 212 4 5 5 CD cord-261417-4pf5nsw2 212 5 ) ) -RRB- cord-261417-4pf5nsw2 212 6 [ [ -LRB- cord-261417-4pf5nsw2 212 7 105 105 CD cord-261417-4pf5nsw2 212 8 , , , cord-261417-4pf5nsw2 212 9 106 106 CD cord-261417-4pf5nsw2 212 10 ] ] -RRB- cord-261417-4pf5nsw2 212 11 and and CC cord-261417-4pf5nsw2 212 12 localize localize VBP cord-261417-4pf5nsw2 212 13 exclusively exclusively RB cord-261417-4pf5nsw2 212 14 to to IN cord-261417-4pf5nsw2 212 15 the the DT cord-261417-4pf5nsw2 212 16 nucleoplasm nucleoplasm NN cord-261417-4pf5nsw2 212 17 [ [ -LRB- cord-261417-4pf5nsw2 212 18 107 107 CD cord-261417-4pf5nsw2 212 19 ] ] -RRB- cord-261417-4pf5nsw2 212 20 . . . cord-261417-4pf5nsw2 213 1 Due due IN cord-261417-4pf5nsw2 213 2 to to IN cord-261417-4pf5nsw2 213 3 their -PRON- PRP$ cord-261417-4pf5nsw2 213 4 high high JJ cord-261417-4pf5nsw2 213 5 copy copy NN cord-261417-4pf5nsw2 213 6 number number NN cord-261417-4pf5nsw2 213 7 , , , cord-261417-4pf5nsw2 213 8 these these DT cord-261417-4pf5nsw2 213 9 ncRNAs ncRNAs NNPS cord-261417-4pf5nsw2 213 10 were be VBD cord-261417-4pf5nsw2 213 11 used use VBN cord-261417-4pf5nsw2 213 12 as as IN cord-261417-4pf5nsw2 213 13 diagnostic diagnostic JJ cord-261417-4pf5nsw2 213 14 tool tool NN cord-261417-4pf5nsw2 213 15 for for IN cord-261417-4pf5nsw2 213 16 EBV EBV NNP cord-261417-4pf5nsw2 213 17 infection infection NN cord-261417-4pf5nsw2 213 18 [ [ -LRB- cord-261417-4pf5nsw2 213 19 108 108 CD cord-261417-4pf5nsw2 213 20 ] ] -RRB- cord-261417-4pf5nsw2 213 21 , , , cord-261417-4pf5nsw2 213 22 but but CC cord-261417-4pf5nsw2 213 23 their -PRON- PRP$ cord-261417-4pf5nsw2 213 24 function function NN cord-261417-4pf5nsw2 213 25 remained remain VBD cord-261417-4pf5nsw2 213 26 unknown unknown JJ cord-261417-4pf5nsw2 213 27 . . . cord-261417-4pf5nsw2 214 1 Employing employ VBG cord-261417-4pf5nsw2 214 2 a a DT cord-261417-4pf5nsw2 214 3 technique technique NN cord-261417-4pf5nsw2 214 4 named name VBN cord-261417-4pf5nsw2 214 5 ' ' `` cord-261417-4pf5nsw2 214 6 capture capture NN cord-261417-4pf5nsw2 214 7 hybridization hybridization NN cord-261417-4pf5nsw2 214 8 analysis analysis NN cord-261417-4pf5nsw2 214 9 of of IN cord-261417-4pf5nsw2 214 10 RNA RNA NNP cord-261417-4pf5nsw2 214 11 targets target NNS cord-261417-4pf5nsw2 214 12 ' ' '' cord-261417-4pf5nsw2 214 13 ( ( -LRB- cord-261417-4pf5nsw2 214 14 CHART CHART NNP cord-261417-4pf5nsw2 214 15 ) ) -RRB- cord-261417-4pf5nsw2 214 16 , , , cord-261417-4pf5nsw2 214 17 Lee Lee NNP cord-261417-4pf5nsw2 214 18 et et NNP cord-261417-4pf5nsw2 214 19 al al NNP cord-261417-4pf5nsw2 214 20 . . . cord-261417-4pf5nsw2 215 1 [ [ -LRB- cord-261417-4pf5nsw2 215 2 75 75 CD cord-261417-4pf5nsw2 215 3 ] ] -RRB- cord-261417-4pf5nsw2 215 4 found find VBD cord-261417-4pf5nsw2 215 5 that that IN cord-261417-4pf5nsw2 215 6 EBER2 EBER2 NNS cord-261417-4pf5nsw2 215 7 localizes localize VBZ cord-261417-4pf5nsw2 215 8 to to IN cord-261417-4pf5nsw2 215 9 the the DT cord-261417-4pf5nsw2 215 10 terminal terminal NN cord-261417-4pf5nsw2 215 11 repeats repeat NNS cord-261417-4pf5nsw2 215 12 ( ( -LRB- cord-261417-4pf5nsw2 215 13 TRs TRs NNP cord-261417-4pf5nsw2 215 14 ) ) -RRB- cord-261417-4pf5nsw2 215 15 in in IN cord-261417-4pf5nsw2 215 16 the the DT cord-261417-4pf5nsw2 215 17 latent latent JJ cord-261417-4pf5nsw2 215 18 EBV EBV NNP cord-261417-4pf5nsw2 215 19 genome genome NN cord-261417-4pf5nsw2 215 20 . . . cord-261417-4pf5nsw2 216 1 TRs tr NNS cord-261417-4pf5nsw2 216 2 are be VBP cord-261417-4pf5nsw2 216 3 tandem tandem JJ cord-261417-4pf5nsw2 216 4 direct direct JJ cord-261417-4pf5nsw2 216 5 repeats repeat NNS cord-261417-4pf5nsw2 216 6 of of IN cord-261417-4pf5nsw2 216 7 approximately approximately RB cord-261417-4pf5nsw2 216 8 550 550 CD cord-261417-4pf5nsw2 216 9 bp bp NNP cord-261417-4pf5nsw2 216 10 that that WDT cord-261417-4pf5nsw2 216 11 flank flank VBD cord-261417-4pf5nsw2 216 12 both both DT cord-261417-4pf5nsw2 216 13 ends end NNS cord-261417-4pf5nsw2 216 14 of of IN cord-261417-4pf5nsw2 216 15 the the DT cord-261417-4pf5nsw2 216 16 linear linear JJ cord-261417-4pf5nsw2 216 17 genome genome NN cord-261417-4pf5nsw2 216 18 present present NN cord-261417-4pf5nsw2 216 19 in in IN cord-261417-4pf5nsw2 216 20 virions virion NNS cord-261417-4pf5nsw2 216 21 and and CC cord-261417-4pf5nsw2 216 22 are be VBP cord-261417-4pf5nsw2 216 23 the the DT cord-261417-4pf5nsw2 216 24 site site NN cord-261417-4pf5nsw2 216 25 of of IN cord-261417-4pf5nsw2 216 26 circularization circularization NN cord-261417-4pf5nsw2 216 27 to to TO cord-261417-4pf5nsw2 216 28 form form VB cord-261417-4pf5nsw2 216 29 the the DT cord-261417-4pf5nsw2 216 30 viral viral JJ cord-261417-4pf5nsw2 216 31 episome episome NN cord-261417-4pf5nsw2 216 32 after after IN cord-261417-4pf5nsw2 216 33 its -PRON- PRP$ cord-261417-4pf5nsw2 216 34 entry entry NN cord-261417-4pf5nsw2 216 35 into into IN cord-261417-4pf5nsw2 216 36 the the DT cord-261417-4pf5nsw2 216 37 host host NN cord-261417-4pf5nsw2 216 38 cell cell NN cord-261417-4pf5nsw2 216 39 [ [ -LRB- cord-261417-4pf5nsw2 216 40 109 109 CD cord-261417-4pf5nsw2 216 41 ] ] -RRB- cord-261417-4pf5nsw2 216 42 . . . cord-261417-4pf5nsw2 217 1 EBER2 EBER2 NNP cord-261417-4pf5nsw2 217 2 localizes localize VBZ cord-261417-4pf5nsw2 217 3 in in IN cord-261417-4pf5nsw2 217 4 the the DT cord-261417-4pf5nsw2 217 5 vicinity vicinity NN cord-261417-4pf5nsw2 217 6 of of IN cord-261417-4pf5nsw2 217 7 a a DT cord-261417-4pf5nsw2 217 8 binding binding JJ cord-261417-4pf5nsw2 217 9 site site NN cord-261417-4pf5nsw2 217 10 for for IN cord-261417-4pf5nsw2 217 11 the the DT cord-261417-4pf5nsw2 217 12 paired pair VBN cord-261417-4pf5nsw2 217 13 box box NN cord-261417-4pf5nsw2 217 14 protein protein NN cord-261417-4pf5nsw2 217 15 5 5 CD cord-261417-4pf5nsw2 217 16 ( ( -LRB- cord-261417-4pf5nsw2 217 17 PAX5 PAX5 NNP cord-261417-4pf5nsw2 217 18 ) ) -RRB- cord-261417-4pf5nsw2 217 19 host host NN cord-261417-4pf5nsw2 217 20 transcription transcription NN cord-261417-4pf5nsw2 217 21 factor factor NN cord-261417-4pf5nsw2 217 22 [ [ -LRB- cord-261417-4pf5nsw2 217 23 110 110 CD cord-261417-4pf5nsw2 217 24 ] ] -RRB- cord-261417-4pf5nsw2 217 25 . . . cord-261417-4pf5nsw2 218 1 This this DT cord-261417-4pf5nsw2 218 2 co co NN cord-261417-4pf5nsw2 218 3 - - NN cord-261417-4pf5nsw2 218 4 localization localization NN cord-261417-4pf5nsw2 218 5 suggested suggest VBD cord-261417-4pf5nsw2 218 6 that that IN cord-261417-4pf5nsw2 218 7 these these DT cord-261417-4pf5nsw2 218 8 factors factor NNS cord-261417-4pf5nsw2 218 9 collaborate collaborate VBP cord-261417-4pf5nsw2 218 10 in in IN cord-261417-4pf5nsw2 218 11 some some DT cord-261417-4pf5nsw2 218 12 way way NN cord-261417-4pf5nsw2 218 13 , , , cord-261417-4pf5nsw2 218 14 and and CC cord-261417-4pf5nsw2 218 15 Lee Lee NNP cord-261417-4pf5nsw2 218 16 et et NNP cord-261417-4pf5nsw2 218 17 al al NNP cord-261417-4pf5nsw2 218 18 . . . cord-261417-4pf5nsw2 219 1 show show VB cord-261417-4pf5nsw2 219 2 that that IN cord-261417-4pf5nsw2 219 3 EBER2 EBER2 NNP cord-261417-4pf5nsw2 219 4 interacts interact VBZ cord-261417-4pf5nsw2 219 5 with with IN cord-261417-4pf5nsw2 219 6 PAX5 PAX5 NNP cord-261417-4pf5nsw2 219 7 , , , cord-261417-4pf5nsw2 219 8 albeit albeit IN cord-261417-4pf5nsw2 219 9 indirectly indirectly RB cord-261417-4pf5nsw2 219 10 through through IN cord-261417-4pf5nsw2 219 11 an an DT cord-261417-4pf5nsw2 219 12 as as RB cord-261417-4pf5nsw2 219 13 - - HYPH cord-261417-4pf5nsw2 219 14 yet yet RB cord-261417-4pf5nsw2 219 15 unidentified unidentified JJ cord-261417-4pf5nsw2 219 16 bridging bridging NN cord-261417-4pf5nsw2 219 17 factor factor NN cord-261417-4pf5nsw2 219 18 . . . cord-261417-4pf5nsw2 220 1 PAX5 PAX5 NNP cord-261417-4pf5nsw2 220 2 is be VBZ cord-261417-4pf5nsw2 220 3 known know VBN cord-261417-4pf5nsw2 220 4 to to TO cord-261417-4pf5nsw2 220 5 downregulate downregulate VB cord-261417-4pf5nsw2 220 6 viral viral JJ cord-261417-4pf5nsw2 220 7 latent latent NN cord-261417-4pf5nsw2 220 8 membrane membrane NN cord-261417-4pf5nsw2 220 9 protein protein NN cord-261417-4pf5nsw2 220 10 1/2A/2B 1/2A/2B NNP cord-261417-4pf5nsw2 220 11 ( ( -LRB- cord-261417-4pf5nsw2 220 12 LMP1/2 LMP1/2 NNP cord-261417-4pf5nsw2 220 13 ) ) -RRB- cord-261417-4pf5nsw2 221 1 gene gene NN cord-261417-4pf5nsw2 221 2 expression expression NN cord-261417-4pf5nsw2 221 3 and and CC cord-261417-4pf5nsw2 221 4 entry entry NN cord-261417-4pf5nsw2 221 5 into into IN cord-261417-4pf5nsw2 221 6 EBV EBV NNP cord-261417-4pf5nsw2 221 7 lytic lytic JJ cord-261417-4pf5nsw2 221 8 replication replication NN cord-261417-4pf5nsw2 221 9 [ [ -LRB- cord-261417-4pf5nsw2 221 10 111 111 CD cord-261417-4pf5nsw2 221 11 , , , cord-261417-4pf5nsw2 221 12 112 112 CD cord-261417-4pf5nsw2 221 13 ] ] -RRB- cord-261417-4pf5nsw2 221 14 . . . cord-261417-4pf5nsw2 222 1 Top top JJ cord-261417-4pf5nsw2 222 2 candidates candidate NNS cord-261417-4pf5nsw2 222 3 for for IN cord-261417-4pf5nsw2 222 4 this this DT cord-261417-4pf5nsw2 222 5 bridging bridging NN cord-261417-4pf5nsw2 222 6 factor factor NN cord-261417-4pf5nsw2 222 7 include include VBP cord-261417-4pf5nsw2 222 8 three three CD cord-261417-4pf5nsw2 222 9 host host NN cord-261417-4pf5nsw2 222 10 proteins protein NNS cord-261417-4pf5nsw2 222 11 : : : cord-261417-4pf5nsw2 222 12 splicing splicing NN cord-261417-4pf5nsw2 222 13 factor factor NN cord-261417-4pf5nsw2 222 14 proline proline NN cord-261417-4pf5nsw2 222 15 and and CC cord-261417-4pf5nsw2 222 16 glutamine glutamine NN cord-261417-4pf5nsw2 222 17 rich rich JJ cord-261417-4pf5nsw2 222 18 ( ( -LRB- cord-261417-4pf5nsw2 222 19 SFPQ SFPQ NNP cord-261417-4pf5nsw2 222 20 ) ) -RRB- cord-261417-4pf5nsw2 222 21 , , , cord-261417-4pf5nsw2 222 22 non non JJ cord-261417-4pf5nsw2 222 23 - - JJ cord-261417-4pf5nsw2 222 24 POU POU NNP cord-261417-4pf5nsw2 222 25 domain domain NN cord-261417-4pf5nsw2 222 26 - - HYPH cord-261417-4pf5nsw2 222 27 containing contain VBG cord-261417-4pf5nsw2 222 28 octamer octamer NN cord-261417-4pf5nsw2 222 29 - - HYPH cord-261417-4pf5nsw2 222 30 binding bind VBG cord-261417-4pf5nsw2 222 31 protein protein NN cord-261417-4pf5nsw2 222 32 ( ( -LRB- cord-261417-4pf5nsw2 222 33 NONO NONO NNP cord-261417-4pf5nsw2 222 34 ) ) -RRB- cord-261417-4pf5nsw2 222 35 , , , cord-261417-4pf5nsw2 222 36 and and CC cord-261417-4pf5nsw2 222 37 RNA rna NN cord-261417-4pf5nsw2 222 38 - - HYPH cord-261417-4pf5nsw2 222 39 binding bind VBG cord-261417-4pf5nsw2 222 40 motif motif NN cord-261417-4pf5nsw2 222 41 protein protein NN cord-261417-4pf5nsw2 222 42 14 14 CD cord-261417-4pf5nsw2 222 43 ( ( -LRB- cord-261417-4pf5nsw2 222 44 RBM14 rbm14 NN cord-261417-4pf5nsw2 222 45 ) ) -RRB- cord-261417-4pf5nsw2 223 1 [ [ -LRB- cord-261417-4pf5nsw2 223 2 112 112 CD cord-261417-4pf5nsw2 223 3 ] ] -RRB- cord-261417-4pf5nsw2 223 4 . . . cord-261417-4pf5nsw2 224 1 SFPQ SFPQ NNP cord-261417-4pf5nsw2 224 2 and and CC cord-261417-4pf5nsw2 224 3 RBM14 RBM14 NNP cord-261417-4pf5nsw2 224 4 contact contact NN cord-261417-4pf5nsw2 224 5 EBER2 EBER2 NNS cord-261417-4pf5nsw2 224 6 directly directly RB cord-261417-4pf5nsw2 224 7 as as IN cord-261417-4pf5nsw2 224 8 shown show VBN cord-261417-4pf5nsw2 224 9 by by IN cord-261417-4pf5nsw2 224 10 RNA rna NN cord-261417-4pf5nsw2 224 11 - - HYPH cord-261417-4pf5nsw2 224 12 protein protein NN cord-261417-4pf5nsw2 224 13 crosslinking crosslinking NN cord-261417-4pf5nsw2 224 14 , , , cord-261417-4pf5nsw2 224 15 and and CC cord-261417-4pf5nsw2 224 16 binding binding NN cord-261417-4pf5nsw2 224 17 studies study NNS cord-261417-4pf5nsw2 224 18 show show VBP cord-261417-4pf5nsw2 224 19 that that IN cord-261417-4pf5nsw2 224 20 SFPQ SFPQ NNP cord-261417-4pf5nsw2 224 21 and and CC cord-261417-4pf5nsw2 224 22 NONO NONO NNP cord-261417-4pf5nsw2 224 23 associate associate VB cord-261417-4pf5nsw2 224 24 with with IN cord-261417-4pf5nsw2 224 25 PAX5 PAX5 NNP cord-261417-4pf5nsw2 224 26 ( ( -LRB- cord-261417-4pf5nsw2 224 27 Figure Figure NNP cord-261417-4pf5nsw2 224 28 4 4 CD cord-261417-4pf5nsw2 224 29 ) ) -RRB- cord-261417-4pf5nsw2 224 30 . . . cord-261417-4pf5nsw2 225 1 EBER2 EBER2 NNP cord-261417-4pf5nsw2 225 2 depletion depletion NN cord-261417-4pf5nsw2 225 3 abrogates abrogate VBZ cord-261417-4pf5nsw2 225 4 PAX5 PAX5 NNP cord-261417-4pf5nsw2 225 5 recruitment recruitment NN cord-261417-4pf5nsw2 225 6 to to IN cord-261417-4pf5nsw2 225 7 the the DT cord-261417-4pf5nsw2 225 8 TR tr NN cord-261417-4pf5nsw2 225 9 , , , cord-261417-4pf5nsw2 225 10 but but CC cord-261417-4pf5nsw2 225 11 PAX5 pax5 JJ cord-261417-4pf5nsw2 225 12 depletion depletion NN cord-261417-4pf5nsw2 225 13 has have VBZ cord-261417-4pf5nsw2 225 14 no no DT cord-261417-4pf5nsw2 225 15 effect effect NN cord-261417-4pf5nsw2 225 16 on on IN cord-261417-4pf5nsw2 225 17 EBER2 EBER2 NNS cord-261417-4pf5nsw2 225 18 localization localization NN cord-261417-4pf5nsw2 225 19 , , , cord-261417-4pf5nsw2 225 20 suggesting suggest VBG cord-261417-4pf5nsw2 225 21 that that IN cord-261417-4pf5nsw2 225 22 this this DT cord-261417-4pf5nsw2 225 23 ncRNA ncrna NN cord-261417-4pf5nsw2 225 24 is be VBZ cord-261417-4pf5nsw2 225 25 used use VBN cord-261417-4pf5nsw2 225 26 to to TO cord-261417-4pf5nsw2 225 27 recruit recruit VB cord-261417-4pf5nsw2 225 28 PAX5 PAX5 NNP cord-261417-4pf5nsw2 225 29 to to IN cord-261417-4pf5nsw2 225 30 the the DT cord-261417-4pf5nsw2 225 31 TR tr NN cord-261417-4pf5nsw2 225 32 . . . cord-261417-4pf5nsw2 226 1 Indeed indeed RB cord-261417-4pf5nsw2 226 2 , , , cord-261417-4pf5nsw2 226 3 EBER2 eber2 NN cord-261417-4pf5nsw2 226 4 base base NN cord-261417-4pf5nsw2 226 5 pairs pair NNS cord-261417-4pf5nsw2 226 6 with with IN cord-261417-4pf5nsw2 226 7 nascent nascent JJ cord-261417-4pf5nsw2 226 8 transcripts transcript NNS cord-261417-4pf5nsw2 226 9 generated generate VBN cord-261417-4pf5nsw2 226 10 from from IN cord-261417-4pf5nsw2 226 11 the the DT cord-261417-4pf5nsw2 226 12 TR tr NN cord-261417-4pf5nsw2 226 13 regions region NNS cord-261417-4pf5nsw2 226 14 , , , cord-261417-4pf5nsw2 226 15 thus thus RB cord-261417-4pf5nsw2 226 16 potentially potentially RB cord-261417-4pf5nsw2 226 17 targeting target VBG cord-261417-4pf5nsw2 226 18 the the DT cord-261417-4pf5nsw2 226 19 interacting interact VBG cord-261417-4pf5nsw2 226 20 PAX5 PAX5 NNP cord-261417-4pf5nsw2 226 21 TF TF NNP cord-261417-4pf5nsw2 226 22 to to IN cord-261417-4pf5nsw2 226 23 its -PRON- PRP$ cord-261417-4pf5nsw2 226 24 consensus consensus NN cord-261417-4pf5nsw2 226 25 sequence sequence NN cord-261417-4pf5nsw2 226 26 sites site NNS cord-261417-4pf5nsw2 226 27 within within IN cord-261417-4pf5nsw2 226 28 the the DT cord-261417-4pf5nsw2 226 29 TRs tr NNS cord-261417-4pf5nsw2 226 30 and and CC cord-261417-4pf5nsw2 226 31 facilitating facilitate VBG cord-261417-4pf5nsw2 226 32 its -PRON- PRP$ cord-261417-4pf5nsw2 226 33 binding binding NN cord-261417-4pf5nsw2 226 34 . . . cord-261417-4pf5nsw2 227 1 Lee Lee NNP cord-261417-4pf5nsw2 227 2 et et NNP cord-261417-4pf5nsw2 227 3 al al NNP cord-261417-4pf5nsw2 227 4 . . . cord-261417-4pf5nsw2 228 1 [ [ -LRB- cord-261417-4pf5nsw2 228 2 75 75 CD cord-261417-4pf5nsw2 228 3 ] ] -RRB- cord-261417-4pf5nsw2 228 4 found find VBD cord-261417-4pf5nsw2 228 5 that that IN cord-261417-4pf5nsw2 228 6 EBER2 EBER2 NNS cord-261417-4pf5nsw2 228 7 localizes localize VBZ cord-261417-4pf5nsw2 228 8 to to IN cord-261417-4pf5nsw2 228 9 the the DT cord-261417-4pf5nsw2 228 10 terminal terminal NN cord-261417-4pf5nsw2 228 11 repeats repeat NNS cord-261417-4pf5nsw2 228 12 ( ( -LRB- cord-261417-4pf5nsw2 228 13 TRs TRs NNP cord-261417-4pf5nsw2 228 14 ) ) -RRB- cord-261417-4pf5nsw2 228 15 in in IN cord-261417-4pf5nsw2 228 16 the the DT cord-261417-4pf5nsw2 228 17 latent latent JJ cord-261417-4pf5nsw2 228 18 EBV EBV NNP cord-261417-4pf5nsw2 228 19 genome genome NN cord-261417-4pf5nsw2 228 20 . . . cord-261417-4pf5nsw2 229 1 TRs tr NNS cord-261417-4pf5nsw2 229 2 are be VBP cord-261417-4pf5nsw2 229 3 tandem tandem JJ cord-261417-4pf5nsw2 229 4 direct direct JJ cord-261417-4pf5nsw2 229 5 repeats repeat NNS cord-261417-4pf5nsw2 229 6 of of IN cord-261417-4pf5nsw2 229 7 approximately approximately RB cord-261417-4pf5nsw2 229 8 550 550 CD cord-261417-4pf5nsw2 229 9 bp bp NNP cord-261417-4pf5nsw2 229 10 that that WDT cord-261417-4pf5nsw2 229 11 flank flank VBD cord-261417-4pf5nsw2 229 12 both both DT cord-261417-4pf5nsw2 229 13 ends end NNS cord-261417-4pf5nsw2 229 14 of of IN cord-261417-4pf5nsw2 229 15 the the DT cord-261417-4pf5nsw2 229 16 linear linear JJ cord-261417-4pf5nsw2 229 17 genome genome NN cord-261417-4pf5nsw2 229 18 present present NN cord-261417-4pf5nsw2 229 19 in in IN cord-261417-4pf5nsw2 229 20 virions virion NNS cord-261417-4pf5nsw2 229 21 and and CC cord-261417-4pf5nsw2 229 22 are be VBP cord-261417-4pf5nsw2 229 23 the the DT cord-261417-4pf5nsw2 229 24 site site NN cord-261417-4pf5nsw2 229 25 of of IN cord-261417-4pf5nsw2 229 26 circularization circularization NN cord-261417-4pf5nsw2 229 27 to to TO cord-261417-4pf5nsw2 229 28 form form VB cord-261417-4pf5nsw2 229 29 the the DT cord-261417-4pf5nsw2 229 30 viral viral JJ cord-261417-4pf5nsw2 229 31 episome episome NN cord-261417-4pf5nsw2 229 32 after after IN cord-261417-4pf5nsw2 229 33 its -PRON- PRP$ cord-261417-4pf5nsw2 229 34 entry entry NN cord-261417-4pf5nsw2 229 35 into into IN cord-261417-4pf5nsw2 229 36 the the DT cord-261417-4pf5nsw2 229 37 host host NN cord-261417-4pf5nsw2 229 38 cell cell NN cord-261417-4pf5nsw2 229 39 [ [ -LRB- cord-261417-4pf5nsw2 229 40 109 109 CD cord-261417-4pf5nsw2 229 41 ] ] -RRB- cord-261417-4pf5nsw2 229 42 . . . cord-261417-4pf5nsw2 230 1 EBER2 EBER2 NNP cord-261417-4pf5nsw2 230 2 localizes localize VBZ cord-261417-4pf5nsw2 230 3 in in IN cord-261417-4pf5nsw2 230 4 the the DT cord-261417-4pf5nsw2 230 5 vicinity vicinity NN cord-261417-4pf5nsw2 230 6 of of IN cord-261417-4pf5nsw2 230 7 a a DT cord-261417-4pf5nsw2 230 8 binding binding JJ cord-261417-4pf5nsw2 230 9 site site NN cord-261417-4pf5nsw2 230 10 for for IN cord-261417-4pf5nsw2 230 11 the the DT cord-261417-4pf5nsw2 230 12 paired pair VBN cord-261417-4pf5nsw2 230 13 box box NN cord-261417-4pf5nsw2 230 14 protein protein NN cord-261417-4pf5nsw2 230 15 5 5 CD cord-261417-4pf5nsw2 230 16 ( ( -LRB- cord-261417-4pf5nsw2 230 17 PAX5 PAX5 NNP cord-261417-4pf5nsw2 230 18 ) ) -RRB- cord-261417-4pf5nsw2 230 19 host host NN cord-261417-4pf5nsw2 230 20 transcription transcription NN cord-261417-4pf5nsw2 230 21 factor factor NN cord-261417-4pf5nsw2 230 22 [ [ -LRB- cord-261417-4pf5nsw2 230 23 110 110 CD cord-261417-4pf5nsw2 230 24 ] ] -RRB- cord-261417-4pf5nsw2 230 25 . . . cord-261417-4pf5nsw2 231 1 This this DT cord-261417-4pf5nsw2 231 2 co co NN cord-261417-4pf5nsw2 231 3 - - NN cord-261417-4pf5nsw2 231 4 localization localization NN cord-261417-4pf5nsw2 231 5 suggested suggest VBD cord-261417-4pf5nsw2 231 6 that that IN cord-261417-4pf5nsw2 231 7 these these DT cord-261417-4pf5nsw2 231 8 factors factor NNS cord-261417-4pf5nsw2 231 9 collaborate collaborate VBP cord-261417-4pf5nsw2 231 10 in in IN cord-261417-4pf5nsw2 231 11 some some DT cord-261417-4pf5nsw2 231 12 way way NN cord-261417-4pf5nsw2 231 13 , , , cord-261417-4pf5nsw2 231 14 and and CC cord-261417-4pf5nsw2 231 15 Lee Lee NNP cord-261417-4pf5nsw2 231 16 et et NNP cord-261417-4pf5nsw2 231 17 al al NNP cord-261417-4pf5nsw2 231 18 . . . cord-261417-4pf5nsw2 232 1 show show VB cord-261417-4pf5nsw2 232 2 that that IN cord-261417-4pf5nsw2 232 3 EBER2 EBER2 NNP cord-261417-4pf5nsw2 232 4 interacts interact VBZ cord-261417-4pf5nsw2 232 5 with with IN cord-261417-4pf5nsw2 232 6 PAX5 PAX5 NNP cord-261417-4pf5nsw2 232 7 , , , cord-261417-4pf5nsw2 232 8 albeit albeit IN cord-261417-4pf5nsw2 232 9 indirectly indirectly RB cord-261417-4pf5nsw2 232 10 through through IN cord-261417-4pf5nsw2 232 11 an an DT cord-261417-4pf5nsw2 232 12 as as RB cord-261417-4pf5nsw2 232 13 - - HYPH cord-261417-4pf5nsw2 232 14 yet yet RB cord-261417-4pf5nsw2 232 15 unidentified unidentified JJ cord-261417-4pf5nsw2 232 16 bridging bridging NN cord-261417-4pf5nsw2 232 17 factor factor NN cord-261417-4pf5nsw2 232 18 . . . cord-261417-4pf5nsw2 233 1 PAX5 PAX5 NNP cord-261417-4pf5nsw2 233 2 is be VBZ cord-261417-4pf5nsw2 233 3 known know VBN cord-261417-4pf5nsw2 233 4 to to TO cord-261417-4pf5nsw2 233 5 downregulate downregulate VB cord-261417-4pf5nsw2 233 6 viral viral JJ cord-261417-4pf5nsw2 233 7 latent latent NN cord-261417-4pf5nsw2 233 8 membrane membrane NN cord-261417-4pf5nsw2 233 9 protein protein NN cord-261417-4pf5nsw2 233 10 1/2A/2B 1/2A/2B NNP cord-261417-4pf5nsw2 233 11 ( ( -LRB- cord-261417-4pf5nsw2 233 12 LMP1/2 LMP1/2 NNP cord-261417-4pf5nsw2 233 13 ) ) -RRB- cord-261417-4pf5nsw2 234 1 gene gene NN cord-261417-4pf5nsw2 234 2 expression expression NN cord-261417-4pf5nsw2 234 3 and and CC cord-261417-4pf5nsw2 234 4 entry entry NN cord-261417-4pf5nsw2 234 5 into into IN cord-261417-4pf5nsw2 234 6 EBV EBV NNP cord-261417-4pf5nsw2 234 7 lytic lytic JJ cord-261417-4pf5nsw2 234 8 replication replication NN cord-261417-4pf5nsw2 234 9 [ [ -LRB- cord-261417-4pf5nsw2 234 10 111 111 CD cord-261417-4pf5nsw2 234 11 , , , cord-261417-4pf5nsw2 234 12 112 112 CD cord-261417-4pf5nsw2 234 13 ] ] -RRB- cord-261417-4pf5nsw2 234 14 . . . cord-261417-4pf5nsw2 235 1 Top top JJ cord-261417-4pf5nsw2 235 2 candidates candidate NNS cord-261417-4pf5nsw2 235 3 for for IN cord-261417-4pf5nsw2 235 4 this this DT cord-261417-4pf5nsw2 235 5 bridging bridging NN cord-261417-4pf5nsw2 235 6 factor factor NN cord-261417-4pf5nsw2 235 7 include include VBP cord-261417-4pf5nsw2 235 8 three three CD cord-261417-4pf5nsw2 235 9 host host NN cord-261417-4pf5nsw2 235 10 proteins protein NNS cord-261417-4pf5nsw2 235 11 : : : cord-261417-4pf5nsw2 235 12 splicing splicing NN cord-261417-4pf5nsw2 235 13 factor factor NN cord-261417-4pf5nsw2 235 14 proline proline NN cord-261417-4pf5nsw2 235 15 and and CC cord-261417-4pf5nsw2 235 16 glutamine glutamine NN cord-261417-4pf5nsw2 235 17 rich rich JJ cord-261417-4pf5nsw2 235 18 ( ( -LRB- cord-261417-4pf5nsw2 235 19 SFPQ SFPQ NNP cord-261417-4pf5nsw2 235 20 ) ) -RRB- cord-261417-4pf5nsw2 235 21 , , , cord-261417-4pf5nsw2 235 22 non non JJ cord-261417-4pf5nsw2 235 23 - - JJ cord-261417-4pf5nsw2 235 24 POU pou JJ cord-261417-4pf5nsw2 235 25 domaincontaining domaincontaine VBG cord-261417-4pf5nsw2 235 26 octamer octamer NN cord-261417-4pf5nsw2 235 27 - - HYPH cord-261417-4pf5nsw2 235 28 binding bind VBG cord-261417-4pf5nsw2 235 29 protein protein NN cord-261417-4pf5nsw2 235 30 ( ( -LRB- cord-261417-4pf5nsw2 235 31 NONO NONO NNP cord-261417-4pf5nsw2 235 32 ) ) -RRB- cord-261417-4pf5nsw2 235 33 , , , cord-261417-4pf5nsw2 235 34 and and CC cord-261417-4pf5nsw2 235 35 RNA rna NN cord-261417-4pf5nsw2 235 36 - - HYPH cord-261417-4pf5nsw2 235 37 binding bind VBG cord-261417-4pf5nsw2 235 38 motif motif NN cord-261417-4pf5nsw2 235 39 protein protein NN cord-261417-4pf5nsw2 235 40 14 14 CD cord-261417-4pf5nsw2 235 41 ( ( -LRB- cord-261417-4pf5nsw2 235 42 RBM14 rbm14 NN cord-261417-4pf5nsw2 235 43 ) ) -RRB- cord-261417-4pf5nsw2 236 1 [ [ -LRB- cord-261417-4pf5nsw2 236 2 112 112 CD cord-261417-4pf5nsw2 236 3 ] ] -RRB- cord-261417-4pf5nsw2 236 4 . . . cord-261417-4pf5nsw2 237 1 SFPQ SFPQ NNP cord-261417-4pf5nsw2 237 2 and and CC cord-261417-4pf5nsw2 237 3 RBM14 RBM14 NNP cord-261417-4pf5nsw2 237 4 contact contact NN cord-261417-4pf5nsw2 237 5 EBER2 EBER2 NNS cord-261417-4pf5nsw2 237 6 directly directly RB cord-261417-4pf5nsw2 237 7 as as IN cord-261417-4pf5nsw2 237 8 shown show VBN cord-261417-4pf5nsw2 237 9 by by IN cord-261417-4pf5nsw2 237 10 RNA rna NN cord-261417-4pf5nsw2 237 11 - - HYPH cord-261417-4pf5nsw2 237 12 protein protein NN cord-261417-4pf5nsw2 237 13 crosslinking crosslinking NN cord-261417-4pf5nsw2 237 14 , , , cord-261417-4pf5nsw2 237 15 and and CC cord-261417-4pf5nsw2 237 16 binding binding NN cord-261417-4pf5nsw2 237 17 studies study NNS cord-261417-4pf5nsw2 237 18 show show VBP cord-261417-4pf5nsw2 237 19 that that IN cord-261417-4pf5nsw2 237 20 SFPQ SFPQ NNP cord-261417-4pf5nsw2 237 21 and and CC cord-261417-4pf5nsw2 237 22 NONO NONO NNP cord-261417-4pf5nsw2 237 23 associate associate VB cord-261417-4pf5nsw2 237 24 with with IN cord-261417-4pf5nsw2 237 25 PAX5 PAX5 NNP cord-261417-4pf5nsw2 237 26 ( ( -LRB- cord-261417-4pf5nsw2 237 27 Figure Figure NNP cord-261417-4pf5nsw2 237 28 4 4 CD cord-261417-4pf5nsw2 237 29 ) ) -RRB- cord-261417-4pf5nsw2 237 30 . . . cord-261417-4pf5nsw2 238 1 EBER2 EBER2 NNP cord-261417-4pf5nsw2 238 2 depletion depletion NN cord-261417-4pf5nsw2 238 3 abrogates abrogate VBZ cord-261417-4pf5nsw2 238 4 PAX5 PAX5 NNP cord-261417-4pf5nsw2 238 5 recruitment recruitment NN cord-261417-4pf5nsw2 238 6 to to IN cord-261417-4pf5nsw2 238 7 the the DT cord-261417-4pf5nsw2 238 8 TR tr NN cord-261417-4pf5nsw2 238 9 , , , cord-261417-4pf5nsw2 238 10 but but CC cord-261417-4pf5nsw2 238 11 PAX5 pax5 JJ cord-261417-4pf5nsw2 238 12 depletion depletion NN cord-261417-4pf5nsw2 238 13 has have VBZ cord-261417-4pf5nsw2 238 14 no no DT cord-261417-4pf5nsw2 238 15 effect effect NN cord-261417-4pf5nsw2 238 16 on on IN cord-261417-4pf5nsw2 238 17 EBER2 EBER2 NNS cord-261417-4pf5nsw2 238 18 localization localization NN cord-261417-4pf5nsw2 238 19 , , , cord-261417-4pf5nsw2 238 20 suggesting suggest VBG cord-261417-4pf5nsw2 238 21 that that IN cord-261417-4pf5nsw2 238 22 this this DT cord-261417-4pf5nsw2 238 23 ncRNA ncrna NN cord-261417-4pf5nsw2 238 24 is be VBZ cord-261417-4pf5nsw2 238 25 used use VBN cord-261417-4pf5nsw2 238 26 to to TO cord-261417-4pf5nsw2 238 27 recruit recruit VB cord-261417-4pf5nsw2 238 28 PAX5 PAX5 NNP cord-261417-4pf5nsw2 238 29 to to IN cord-261417-4pf5nsw2 238 30 the the DT cord-261417-4pf5nsw2 238 31 TR tr NN cord-261417-4pf5nsw2 238 32 . . . cord-261417-4pf5nsw2 239 1 Indeed indeed RB cord-261417-4pf5nsw2 239 2 , , , cord-261417-4pf5nsw2 239 3 EBER2 eber2 NN cord-261417-4pf5nsw2 239 4 base base NN cord-261417-4pf5nsw2 239 5 pairs pair NNS cord-261417-4pf5nsw2 239 6 with with IN cord-261417-4pf5nsw2 239 7 nascent nascent JJ cord-261417-4pf5nsw2 239 8 transcripts transcript NNS cord-261417-4pf5nsw2 239 9 generated generate VBN cord-261417-4pf5nsw2 239 10 from from IN cord-261417-4pf5nsw2 239 11 the the DT cord-261417-4pf5nsw2 239 12 TR tr NN cord-261417-4pf5nsw2 239 13 regions region NNS cord-261417-4pf5nsw2 239 14 , , , cord-261417-4pf5nsw2 239 15 thus thus RB cord-261417-4pf5nsw2 239 16 potentially potentially RB cord-261417-4pf5nsw2 239 17 targeting target VBG cord-261417-4pf5nsw2 239 18 the the DT cord-261417-4pf5nsw2 239 19 interacting interact VBG cord-261417-4pf5nsw2 239 20 PAX5 PAX5 NNP cord-261417-4pf5nsw2 239 21 TF TF NNP cord-261417-4pf5nsw2 239 22 to to IN cord-261417-4pf5nsw2 239 23 its -PRON- PRP$ cord-261417-4pf5nsw2 239 24 consensus consensus NN cord-261417-4pf5nsw2 239 25 sequence sequence NN cord-261417-4pf5nsw2 239 26 sites site NNS cord-261417-4pf5nsw2 239 27 within within IN cord-261417-4pf5nsw2 239 28 the the DT cord-261417-4pf5nsw2 239 29 TRs tr NNS cord-261417-4pf5nsw2 239 30 and and CC cord-261417-4pf5nsw2 239 31 facilitating facilitate VBG cord-261417-4pf5nsw2 239 32 its -PRON- PRP$ cord-261417-4pf5nsw2 239 33 binding binding NN cord-261417-4pf5nsw2 239 34 . . . cord-261417-4pf5nsw2 239 35 _SP cord-261417-4pf5nsw2 240 1 The the DT cord-261417-4pf5nsw2 240 2 last last JJ cord-261417-4pf5nsw2 240 3 stage stage NN cord-261417-4pf5nsw2 240 4 of of IN cord-261417-4pf5nsw2 240 5 transcription transcription NN cord-261417-4pf5nsw2 240 6 is be VBZ cord-261417-4pf5nsw2 240 7 termination termination NN cord-261417-4pf5nsw2 240 8 , , , cord-261417-4pf5nsw2 240 9 which which WDT cord-261417-4pf5nsw2 240 10 leads lead VBZ cord-261417-4pf5nsw2 240 11 to to IN cord-261417-4pf5nsw2 240 12 the the DT cord-261417-4pf5nsw2 240 13 release release NN cord-261417-4pf5nsw2 240 14 of of IN cord-261417-4pf5nsw2 240 15 the the DT cord-261417-4pf5nsw2 240 16 RNA RNA NNP cord-261417-4pf5nsw2 240 17 transcript transcript NN cord-261417-4pf5nsw2 240 18 and and CC cord-261417-4pf5nsw2 240 19 the the DT cord-261417-4pf5nsw2 240 20 dissociation dissociation NN cord-261417-4pf5nsw2 240 21 of of IN cord-261417-4pf5nsw2 240 22 RNAP RNAP NNP cord-261417-4pf5nsw2 240 23 from from IN cord-261417-4pf5nsw2 240 24 the the DT cord-261417-4pf5nsw2 240 25 template template NN cord-261417-4pf5nsw2 240 26 DNA dna NN cord-261417-4pf5nsw2 240 27 . . . cord-261417-4pf5nsw2 241 1 Upon upon IN cord-261417-4pf5nsw2 241 2 encountering encounter VBG cord-261417-4pf5nsw2 241 3 sequence sequence NN cord-261417-4pf5nsw2 241 4 - - HYPH cord-261417-4pf5nsw2 241 5 encoded encode VBN cord-261417-4pf5nsw2 241 6 termination termination NN cord-261417-4pf5nsw2 241 7 signals signal NNS cord-261417-4pf5nsw2 241 8 ( ( -LRB- cord-261417-4pf5nsw2 242 1 e.g. e.g. RB cord-261417-4pf5nsw2 242 2 , , , cord-261417-4pf5nsw2 242 3 the the DT cord-261417-4pf5nsw2 242 4 canonical canonical JJ cord-261417-4pf5nsw2 242 5 polyadenylation polyadenylation NN cord-261417-4pf5nsw2 242 6 signal signal NN cord-261417-4pf5nsw2 242 7 , , , cord-261417-4pf5nsw2 242 8 AAUAAA AAUAAA NNP cord-261417-4pf5nsw2 242 9 ) ) -RRB- cord-261417-4pf5nsw2 242 10 , , , cord-261417-4pf5nsw2 242 11 factors factor NNS cord-261417-4pf5nsw2 242 12 will will MD cord-261417-4pf5nsw2 242 13 be be VB cord-261417-4pf5nsw2 242 14 recruited recruit VBN cord-261417-4pf5nsw2 242 15 that that TO cord-261417-4pf5nsw2 242 16 cleave cleave VB cord-261417-4pf5nsw2 242 17 and and CC cord-261417-4pf5nsw2 242 18 modify modify VB cord-261417-4pf5nsw2 242 19 the the DT cord-261417-4pf5nsw2 242 20 RNA RNA NNP cord-261417-4pf5nsw2 242 21 3′ 3′ CD cord-261417-4pf5nsw2 242 22 end end NN cord-261417-4pf5nsw2 242 23 . . . cord-261417-4pf5nsw2 243 1 Eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 243 2 mRNA mrna NN cord-261417-4pf5nsw2 243 3 undergoes undergo VBZ cord-261417-4pf5nsw2 243 4 multiple multiple JJ cord-261417-4pf5nsw2 243 5 types type NNS cord-261417-4pf5nsw2 243 6 of of IN cord-261417-4pf5nsw2 243 7 modifications modification NNS cord-261417-4pf5nsw2 243 8 at at IN cord-261417-4pf5nsw2 243 9 its -PRON- PRP$ cord-261417-4pf5nsw2 243 10 3′ 3′ CD cord-261417-4pf5nsw2 243 11 end end NN cord-261417-4pf5nsw2 243 12 throughout throughout IN cord-261417-4pf5nsw2 243 13 its -PRON- PRP$ cord-261417-4pf5nsw2 243 14 life life NN cord-261417-4pf5nsw2 243 15 cycle cycle NN cord-261417-4pf5nsw2 243 16 [ [ -LRB- cord-261417-4pf5nsw2 243 17 113 113 CD cord-261417-4pf5nsw2 243 18 ] ] -RRB- cord-261417-4pf5nsw2 243 19 . . . cord-261417-4pf5nsw2 244 1 For for IN cord-261417-4pf5nsw2 244 2 example example NN cord-261417-4pf5nsw2 244 3 , , , cord-261417-4pf5nsw2 244 4 newly newly RB cord-261417-4pf5nsw2 244 5 synthesized synthesize VBN cord-261417-4pf5nsw2 244 6 mRNA mrna NN cord-261417-4pf5nsw2 244 7 acquires acquire VBZ cord-261417-4pf5nsw2 244 8 a a DT cord-261417-4pf5nsw2 244 9 long long JJ cord-261417-4pf5nsw2 244 10 poly poly NN cord-261417-4pf5nsw2 244 11 ( ( -LRB- cord-261417-4pf5nsw2 244 12 A a NN cord-261417-4pf5nsw2 244 13 ) ) -RRB- cord-261417-4pf5nsw2 244 14 tail tail NN cord-261417-4pf5nsw2 244 15 ( ( -LRB- cord-261417-4pf5nsw2 244 16 up up IN cord-261417-4pf5nsw2 244 17 to to IN cord-261417-4pf5nsw2 244 18 ∼250 ∼250 NNP cord-261417-4pf5nsw2 244 19 nt nt RB cord-261417-4pf5nsw2 244 20 ) ) -RRB- cord-261417-4pf5nsw2 244 21 through through IN cord-261417-4pf5nsw2 244 22 canonical canonical JJ cord-261417-4pf5nsw2 244 23 transcription transcription NN cord-261417-4pf5nsw2 244 24 - - HYPH cord-261417-4pf5nsw2 244 25 coupled couple VBN cord-261417-4pf5nsw2 244 26 polyadenylation polyadenylation NN cord-261417-4pf5nsw2 244 27 , , , cord-261417-4pf5nsw2 244 28 which which WDT cord-261417-4pf5nsw2 244 29 facilitates facilitate VBZ cord-261417-4pf5nsw2 244 30 mRNA mrna NN cord-261417-4pf5nsw2 244 31 export export NN cord-261417-4pf5nsw2 244 32 from from IN cord-261417-4pf5nsw2 244 33 the the DT cord-261417-4pf5nsw2 244 34 nucleus nucleus NN cord-261417-4pf5nsw2 244 35 [ [ -LRB- cord-261417-4pf5nsw2 244 36 114 114 CD cord-261417-4pf5nsw2 244 37 , , , cord-261417-4pf5nsw2 244 38 115 115 CD cord-261417-4pf5nsw2 244 39 ] ] -RRB- cord-261417-4pf5nsw2 244 40 . . . cord-261417-4pf5nsw2 245 1 In in IN cord-261417-4pf5nsw2 245 2 the the DT cord-261417-4pf5nsw2 245 3 cytoplasm cytoplasm NN cord-261417-4pf5nsw2 245 4 , , , cord-261417-4pf5nsw2 245 5 poly(A poly(A NNP cord-261417-4pf5nsw2 245 6 ) ) -RRB- cord-261417-4pf5nsw2 245 7 tails tail NNS cord-261417-4pf5nsw2 245 8 are be VBP cord-261417-4pf5nsw2 245 9 associated associate VBN cord-261417-4pf5nsw2 245 10 with with IN cord-261417-4pf5nsw2 245 11 poly(A)-binding poly(a)-binde VBG cord-261417-4pf5nsw2 245 12 proteins protein NNS cord-261417-4pf5nsw2 245 13 ( ( -LRB- cord-261417-4pf5nsw2 245 14 PABPCs pabpc NNS cord-261417-4pf5nsw2 245 15 ) ) -RRB- cord-261417-4pf5nsw2 245 16 that that WDT cord-261417-4pf5nsw2 245 17 stabilize stabilize VBP cord-261417-4pf5nsw2 245 18 the the DT cord-261417-4pf5nsw2 245 19 mRNA mrna NN cord-261417-4pf5nsw2 245 20 by by IN cord-261417-4pf5nsw2 245 21 acting act VBG cord-261417-4pf5nsw2 245 22 as as IN cord-261417-4pf5nsw2 245 23 a a DT cord-261417-4pf5nsw2 245 24 safeguard safeguard NN cord-261417-4pf5nsw2 245 25 against against IN cord-261417-4pf5nsw2 245 26 multiple multiple JJ cord-261417-4pf5nsw2 245 27 decay decay NN cord-261417-4pf5nsw2 245 28 machineries machinery NNS cord-261417-4pf5nsw2 245 29 and and CC cord-261417-4pf5nsw2 245 30 promote promote VB cord-261417-4pf5nsw2 245 31 protein protein NN cord-261417-4pf5nsw2 245 32 synthesis synthesis NN cord-261417-4pf5nsw2 245 33 [ [ -LRB- cord-261417-4pf5nsw2 245 34 116 116 CD cord-261417-4pf5nsw2 245 35 , , , cord-261417-4pf5nsw2 245 36 117 117 CD cord-261417-4pf5nsw2 245 37 ] ] -RRB- cord-261417-4pf5nsw2 245 38 . . . cord-261417-4pf5nsw2 246 1 mRNAs mrnas LS cord-261417-4pf5nsw2 246 2 carrying carry VBG cord-261417-4pf5nsw2 246 3 short short JJ cord-261417-4pf5nsw2 246 4 poly(A poly(A NNS cord-261417-4pf5nsw2 246 5 ) ) -RRB- cord-261417-4pf5nsw2 246 6 tails tail NNS cord-261417-4pf5nsw2 246 7 ( ( -LRB- cord-261417-4pf5nsw2 246 8 < < NNP cord-261417-4pf5nsw2 246 9 25 25 CD cord-261417-4pf5nsw2 246 10 nt nt NN cord-261417-4pf5nsw2 246 11 ) ) -RRB- cord-261417-4pf5nsw2 246 12 are be VBP cord-261417-4pf5nsw2 246 13 recognized recognize VBN cord-261417-4pf5nsw2 246 14 and and CC cord-261417-4pf5nsw2 246 15 poly poly JJ cord-261417-4pf5nsw2 246 16 - - HYPH cord-261417-4pf5nsw2 246 17 uridylated uridylate VBN cord-261417-4pf5nsw2 246 18 by by IN cord-261417-4pf5nsw2 246 19 terminal terminal JJ cord-261417-4pf5nsw2 246 20 uridylyl uridylyl JJ cord-261417-4pf5nsw2 246 21 transferases transferase NNS cord-261417-4pf5nsw2 246 22 ( ( -LRB- cord-261417-4pf5nsw2 246 23 TUTases TUTases NNP cord-261417-4pf5nsw2 246 24 ) ) -RRB- cord-261417-4pf5nsw2 246 25 4 4 CD cord-261417-4pf5nsw2 246 26 and and CC cord-261417-4pf5nsw2 246 27 7 7 CD cord-261417-4pf5nsw2 246 28 , , , cord-261417-4pf5nsw2 246 29 which which WDT cord-261417-4pf5nsw2 246 30 labels label VBZ cord-261417-4pf5nsw2 246 31 the the DT cord-261417-4pf5nsw2 246 32 mRNA mrna NN cord-261417-4pf5nsw2 246 33 for for IN cord-261417-4pf5nsw2 246 34 degradation degradation NN cord-261417-4pf5nsw2 246 35 [ [ -LRB- cord-261417-4pf5nsw2 246 36 118 118 CD cord-261417-4pf5nsw2 246 37 ] ] -RRB- cord-261417-4pf5nsw2 246 38 . . . cord-261417-4pf5nsw2 247 1 Many many JJ cord-261417-4pf5nsw2 247 2 + + CC cord-261417-4pf5nsw2 247 3 ssRNA ssrna NN cord-261417-4pf5nsw2 247 4 viruses virus NNS cord-261417-4pf5nsw2 247 5 lack lack VBP cord-261417-4pf5nsw2 247 6 a a DT cord-261417-4pf5nsw2 247 7 poly poly NN cord-261417-4pf5nsw2 247 8 ( ( -LRB- cord-261417-4pf5nsw2 247 9 A a NN cord-261417-4pf5nsw2 247 10 ) ) -RRB- cord-261417-4pf5nsw2 247 11 tail tail NN cord-261417-4pf5nsw2 247 12 at at IN cord-261417-4pf5nsw2 247 13 the the DT cord-261417-4pf5nsw2 247 14 3′ 3′ CD cord-261417-4pf5nsw2 247 15 end end NN cord-261417-4pf5nsw2 247 16 of of IN cord-261417-4pf5nsw2 247 17 their -PRON- PRP$ cord-261417-4pf5nsw2 247 18 genome genome NN cord-261417-4pf5nsw2 247 19 , , , cord-261417-4pf5nsw2 247 20 but but CC cord-261417-4pf5nsw2 247 21 are be VBP cord-261417-4pf5nsw2 247 22 still still RB cord-261417-4pf5nsw2 247 23 efficiently efficiently RB cord-261417-4pf5nsw2 247 24 translated translate VBN cord-261417-4pf5nsw2 247 25 . . . cord-261417-4pf5nsw2 248 1 For for IN cord-261417-4pf5nsw2 248 2 instance instance NN cord-261417-4pf5nsw2 248 3 , , , cord-261417-4pf5nsw2 248 4 flaviruses flaviruse NNS cord-261417-4pf5nsw2 248 5 ( ( -LRB- cord-261417-4pf5nsw2 248 6 e.g. e.g. RB cord-261417-4pf5nsw2 248 7 , , , cord-261417-4pf5nsw2 248 8 dengue dengue NN cord-261417-4pf5nsw2 248 9 virus virus NN cord-261417-4pf5nsw2 248 10 , , , cord-261417-4pf5nsw2 248 11 West West NNP cord-261417-4pf5nsw2 248 12 Nile Nile NNP cord-261417-4pf5nsw2 248 13 virus virus NN cord-261417-4pf5nsw2 248 14 ) ) -RRB- cord-261417-4pf5nsw2 248 15 have have VBP cord-261417-4pf5nsw2 248 16 a a DT cord-261417-4pf5nsw2 248 17 capped cap VBN cord-261417-4pf5nsw2 248 18 RNA RNA NNP cord-261417-4pf5nsw2 248 19 genome genome NN cord-261417-4pf5nsw2 248 20 _SP cord-261417-4pf5nsw2 249 1 The the DT cord-261417-4pf5nsw2 249 2 last last JJ cord-261417-4pf5nsw2 249 3 stage stage NN cord-261417-4pf5nsw2 249 4 of of IN cord-261417-4pf5nsw2 249 5 transcription transcription NN cord-261417-4pf5nsw2 249 6 is be VBZ cord-261417-4pf5nsw2 249 7 termination termination NN cord-261417-4pf5nsw2 249 8 , , , cord-261417-4pf5nsw2 249 9 which which WDT cord-261417-4pf5nsw2 249 10 leads lead VBZ cord-261417-4pf5nsw2 249 11 to to IN cord-261417-4pf5nsw2 249 12 the the DT cord-261417-4pf5nsw2 249 13 release release NN cord-261417-4pf5nsw2 249 14 of of IN cord-261417-4pf5nsw2 249 15 the the DT cord-261417-4pf5nsw2 249 16 RNA RNA NNP cord-261417-4pf5nsw2 249 17 transcript transcript NN cord-261417-4pf5nsw2 249 18 and and CC cord-261417-4pf5nsw2 249 19 the the DT cord-261417-4pf5nsw2 249 20 dissociation dissociation NN cord-261417-4pf5nsw2 249 21 of of IN cord-261417-4pf5nsw2 249 22 RNAP RNAP NNP cord-261417-4pf5nsw2 249 23 from from IN cord-261417-4pf5nsw2 249 24 the the DT cord-261417-4pf5nsw2 249 25 template template NN cord-261417-4pf5nsw2 249 26 DNA dna NN cord-261417-4pf5nsw2 249 27 . . . cord-261417-4pf5nsw2 250 1 Upon upon IN cord-261417-4pf5nsw2 250 2 encountering encounter VBG cord-261417-4pf5nsw2 250 3 sequence sequence NN cord-261417-4pf5nsw2 250 4 - - HYPH cord-261417-4pf5nsw2 250 5 encoded encode VBN cord-261417-4pf5nsw2 250 6 termination termination NN cord-261417-4pf5nsw2 250 7 signals signal NNS cord-261417-4pf5nsw2 250 8 ( ( -LRB- cord-261417-4pf5nsw2 251 1 e.g. e.g. RB cord-261417-4pf5nsw2 251 2 , , , cord-261417-4pf5nsw2 251 3 the the DT cord-261417-4pf5nsw2 251 4 canonical canonical JJ cord-261417-4pf5nsw2 251 5 polyadenylation polyadenylation NN cord-261417-4pf5nsw2 251 6 signal signal NN cord-261417-4pf5nsw2 251 7 , , , cord-261417-4pf5nsw2 251 8 AAUAAA AAUAAA NNP cord-261417-4pf5nsw2 251 9 ) ) -RRB- cord-261417-4pf5nsw2 251 10 , , , cord-261417-4pf5nsw2 251 11 factors factor NNS cord-261417-4pf5nsw2 251 12 will will MD cord-261417-4pf5nsw2 251 13 be be VB cord-261417-4pf5nsw2 251 14 recruited recruit VBN cord-261417-4pf5nsw2 251 15 that that TO cord-261417-4pf5nsw2 251 16 cleave cleave VB cord-261417-4pf5nsw2 251 17 and and CC cord-261417-4pf5nsw2 251 18 modify modify VB cord-261417-4pf5nsw2 251 19 the the DT cord-261417-4pf5nsw2 251 20 RNA RNA NNP cord-261417-4pf5nsw2 251 21 3 3 CD cord-261417-4pf5nsw2 251 22 end end NN cord-261417-4pf5nsw2 251 23 . . . cord-261417-4pf5nsw2 252 1 Eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 252 2 mRNA mrna NN cord-261417-4pf5nsw2 252 3 undergoes undergo VBZ cord-261417-4pf5nsw2 252 4 multiple multiple JJ cord-261417-4pf5nsw2 252 5 types type NNS cord-261417-4pf5nsw2 252 6 of of IN cord-261417-4pf5nsw2 252 7 modifications modification NNS cord-261417-4pf5nsw2 252 8 at at IN cord-261417-4pf5nsw2 252 9 its -PRON- PRP$ cord-261417-4pf5nsw2 252 10 3 3 CD cord-261417-4pf5nsw2 252 11 end end NN cord-261417-4pf5nsw2 252 12 throughout throughout IN cord-261417-4pf5nsw2 252 13 its -PRON- PRP$ cord-261417-4pf5nsw2 252 14 life life NN cord-261417-4pf5nsw2 252 15 cycle cycle NN cord-261417-4pf5nsw2 252 16 [ [ -LRB- cord-261417-4pf5nsw2 252 17 113 113 CD cord-261417-4pf5nsw2 252 18 ] ] -RRB- cord-261417-4pf5nsw2 252 19 . . . cord-261417-4pf5nsw2 253 1 For for IN cord-261417-4pf5nsw2 253 2 example example NN cord-261417-4pf5nsw2 253 3 , , , cord-261417-4pf5nsw2 253 4 newly newly RB cord-261417-4pf5nsw2 253 5 synthesized synthesize VBN cord-261417-4pf5nsw2 253 6 mRNA mrna NN cord-261417-4pf5nsw2 253 7 acquires acquire VBZ cord-261417-4pf5nsw2 253 8 a a DT cord-261417-4pf5nsw2 253 9 long long JJ cord-261417-4pf5nsw2 253 10 poly poly NN cord-261417-4pf5nsw2 253 11 ( ( -LRB- cord-261417-4pf5nsw2 253 12 A a NN cord-261417-4pf5nsw2 253 13 ) ) -RRB- cord-261417-4pf5nsw2 253 14 tail tail NN cord-261417-4pf5nsw2 253 15 ( ( -LRB- cord-261417-4pf5nsw2 253 16 up up IN cord-261417-4pf5nsw2 253 17 to to IN cord-261417-4pf5nsw2 253 18 ∼250 ∼250 NNP cord-261417-4pf5nsw2 253 19 nt nt RB cord-261417-4pf5nsw2 253 20 ) ) -RRB- cord-261417-4pf5nsw2 253 21 through through IN cord-261417-4pf5nsw2 253 22 canonical canonical JJ cord-261417-4pf5nsw2 253 23 transcription transcription NN cord-261417-4pf5nsw2 253 24 - - HYPH cord-261417-4pf5nsw2 253 25 coupled couple VBN cord-261417-4pf5nsw2 253 26 polyadenylation polyadenylation NN cord-261417-4pf5nsw2 253 27 , , , cord-261417-4pf5nsw2 253 28 which which WDT cord-261417-4pf5nsw2 253 29 facilitates facilitate VBZ cord-261417-4pf5nsw2 253 30 mRNA mrna NN cord-261417-4pf5nsw2 253 31 export export NN cord-261417-4pf5nsw2 253 32 from from IN cord-261417-4pf5nsw2 253 33 the the DT cord-261417-4pf5nsw2 253 34 nucleus nucleus NN cord-261417-4pf5nsw2 253 35 [ [ -LRB- cord-261417-4pf5nsw2 253 36 114 114 CD cord-261417-4pf5nsw2 253 37 , , , cord-261417-4pf5nsw2 253 38 115 115 CD cord-261417-4pf5nsw2 253 39 ] ] -RRB- cord-261417-4pf5nsw2 253 40 . . . cord-261417-4pf5nsw2 254 1 In in IN cord-261417-4pf5nsw2 254 2 the the DT cord-261417-4pf5nsw2 254 3 cytoplasm cytoplasm NN cord-261417-4pf5nsw2 254 4 , , , cord-261417-4pf5nsw2 254 5 poly(A poly(A NNP cord-261417-4pf5nsw2 254 6 ) ) -RRB- cord-261417-4pf5nsw2 254 7 tails tail NNS cord-261417-4pf5nsw2 254 8 are be VBP cord-261417-4pf5nsw2 254 9 associated associate VBN cord-261417-4pf5nsw2 254 10 with with IN cord-261417-4pf5nsw2 254 11 poly(A)-binding poly(a)-binde VBG cord-261417-4pf5nsw2 254 12 proteins protein NNS cord-261417-4pf5nsw2 254 13 ( ( -LRB- cord-261417-4pf5nsw2 254 14 PABPCs pabpc NNS cord-261417-4pf5nsw2 254 15 ) ) -RRB- cord-261417-4pf5nsw2 254 16 that that WDT cord-261417-4pf5nsw2 254 17 stabilize stabilize VBP cord-261417-4pf5nsw2 254 18 the the DT cord-261417-4pf5nsw2 254 19 mRNA mrna NN cord-261417-4pf5nsw2 254 20 by by IN cord-261417-4pf5nsw2 254 21 acting act VBG cord-261417-4pf5nsw2 254 22 as as IN cord-261417-4pf5nsw2 254 23 a a DT cord-261417-4pf5nsw2 254 24 safeguard safeguard NN cord-261417-4pf5nsw2 254 25 against against IN cord-261417-4pf5nsw2 254 26 multiple multiple JJ cord-261417-4pf5nsw2 254 27 decay decay NN cord-261417-4pf5nsw2 254 28 machineries machinery NNS cord-261417-4pf5nsw2 254 29 and and CC cord-261417-4pf5nsw2 254 30 promote promote VB cord-261417-4pf5nsw2 254 31 protein protein NN cord-261417-4pf5nsw2 254 32 synthesis synthesis NN cord-261417-4pf5nsw2 254 33 [ [ -LRB- cord-261417-4pf5nsw2 254 34 116 116 CD cord-261417-4pf5nsw2 254 35 , , , cord-261417-4pf5nsw2 254 36 117 117 CD cord-261417-4pf5nsw2 254 37 ] ] -RRB- cord-261417-4pf5nsw2 254 38 . . . cord-261417-4pf5nsw2 255 1 mRNAs mrnas LS cord-261417-4pf5nsw2 255 2 carrying carry VBG cord-261417-4pf5nsw2 255 3 short short JJ cord-261417-4pf5nsw2 255 4 poly(A poly(A NNS cord-261417-4pf5nsw2 255 5 ) ) -RRB- cord-261417-4pf5nsw2 255 6 tails tail NNS cord-261417-4pf5nsw2 255 7 ( ( -LRB- cord-261417-4pf5nsw2 255 8 < < NNP cord-261417-4pf5nsw2 255 9 25 25 CD cord-261417-4pf5nsw2 255 10 nt nt NN cord-261417-4pf5nsw2 255 11 ) ) -RRB- cord-261417-4pf5nsw2 255 12 are be VBP cord-261417-4pf5nsw2 255 13 recognized recognize VBN cord-261417-4pf5nsw2 255 14 and and CC cord-261417-4pf5nsw2 255 15 poly poly JJ cord-261417-4pf5nsw2 255 16 - - HYPH cord-261417-4pf5nsw2 255 17 uridylated uridylate VBN cord-261417-4pf5nsw2 255 18 by by IN cord-261417-4pf5nsw2 255 19 terminal terminal JJ cord-261417-4pf5nsw2 255 20 uridylyl uridylyl JJ cord-261417-4pf5nsw2 255 21 transferases transferase NNS cord-261417-4pf5nsw2 255 22 ( ( -LRB- cord-261417-4pf5nsw2 255 23 TUTases TUTases NNP cord-261417-4pf5nsw2 255 24 ) ) -RRB- cord-261417-4pf5nsw2 255 25 4 4 CD cord-261417-4pf5nsw2 255 26 and and CC cord-261417-4pf5nsw2 255 27 7 7 CD cord-261417-4pf5nsw2 255 28 , , , cord-261417-4pf5nsw2 255 29 which which WDT cord-261417-4pf5nsw2 255 30 labels label VBZ cord-261417-4pf5nsw2 255 31 the the DT cord-261417-4pf5nsw2 255 32 mRNA mrna NN cord-261417-4pf5nsw2 255 33 for for IN cord-261417-4pf5nsw2 255 34 degradation degradation NN cord-261417-4pf5nsw2 255 35 [ [ -LRB- cord-261417-4pf5nsw2 255 36 118 118 CD cord-261417-4pf5nsw2 255 37 ] ] -RRB- cord-261417-4pf5nsw2 255 38 . . . cord-261417-4pf5nsw2 256 1 Many many JJ cord-261417-4pf5nsw2 256 2 + + CC cord-261417-4pf5nsw2 256 3 ssRNA ssrna NN cord-261417-4pf5nsw2 256 4 viruses virus NNS cord-261417-4pf5nsw2 256 5 lack lack VBP cord-261417-4pf5nsw2 256 6 a a DT cord-261417-4pf5nsw2 256 7 poly poly NN cord-261417-4pf5nsw2 256 8 ( ( -LRB- cord-261417-4pf5nsw2 256 9 A a NN cord-261417-4pf5nsw2 256 10 ) ) -RRB- cord-261417-4pf5nsw2 256 11 tail tail NN cord-261417-4pf5nsw2 256 12 at at IN cord-261417-4pf5nsw2 256 13 the the DT cord-261417-4pf5nsw2 256 14 3 3 CD cord-261417-4pf5nsw2 256 15 end end NN cord-261417-4pf5nsw2 256 16 of of IN cord-261417-4pf5nsw2 256 17 their -PRON- PRP$ cord-261417-4pf5nsw2 256 18 genome genome NN cord-261417-4pf5nsw2 256 19 , , , cord-261417-4pf5nsw2 256 20 but but CC cord-261417-4pf5nsw2 256 21 are be VBP cord-261417-4pf5nsw2 256 22 still still RB cord-261417-4pf5nsw2 256 23 efficiently efficiently RB cord-261417-4pf5nsw2 256 24 translated translate VBN cord-261417-4pf5nsw2 256 25 . . . cord-261417-4pf5nsw2 257 1 For for IN cord-261417-4pf5nsw2 257 2 instance instance NN cord-261417-4pf5nsw2 257 3 , , , cord-261417-4pf5nsw2 257 4 flaviruses flaviruse NNS cord-261417-4pf5nsw2 257 5 ( ( -LRB- cord-261417-4pf5nsw2 257 6 e.g. e.g. RB cord-261417-4pf5nsw2 257 7 , , , cord-261417-4pf5nsw2 257 8 dengue dengue NN cord-261417-4pf5nsw2 257 9 virus virus NN cord-261417-4pf5nsw2 257 10 , , , cord-261417-4pf5nsw2 257 11 West West NNP cord-261417-4pf5nsw2 257 12 Nile Nile NNP cord-261417-4pf5nsw2 257 13 virus virus NN cord-261417-4pf5nsw2 257 14 ) ) -RRB- cord-261417-4pf5nsw2 257 15 have have VBP cord-261417-4pf5nsw2 257 16 a a DT cord-261417-4pf5nsw2 257 17 capped cap VBN cord-261417-4pf5nsw2 257 18 RNA RNA NNP cord-261417-4pf5nsw2 257 19 genome genome NN cord-261417-4pf5nsw2 257 20 which which WDT cord-261417-4pf5nsw2 257 21 contains contain VBZ cord-261417-4pf5nsw2 257 22 conserved conserved JJ cord-261417-4pf5nsw2 257 23 sequences sequence NNS cord-261417-4pf5nsw2 257 24 at at IN cord-261417-4pf5nsw2 257 25 the the DT cord-261417-4pf5nsw2 257 26 5 5 CD cord-261417-4pf5nsw2 257 27 and and CC cord-261417-4pf5nsw2 257 28 3 3 CD cord-261417-4pf5nsw2 257 29 ends end NNS cord-261417-4pf5nsw2 257 30 , , , cord-261417-4pf5nsw2 257 31 allowing allow VBG cord-261417-4pf5nsw2 257 32 for for IN cord-261417-4pf5nsw2 257 33 circularization circularization NN cord-261417-4pf5nsw2 257 34 and and CC cord-261417-4pf5nsw2 257 35 efficient efficient JJ cord-261417-4pf5nsw2 257 36 translation translation NN cord-261417-4pf5nsw2 257 37 [ [ -LRB- cord-261417-4pf5nsw2 257 38 119 119 CD cord-261417-4pf5nsw2 257 39 , , , cord-261417-4pf5nsw2 257 40 120 120 CD cord-261417-4pf5nsw2 257 41 ] ] -RRB- cord-261417-4pf5nsw2 257 42 . . . cord-261417-4pf5nsw2 258 1 Other other JJ cord-261417-4pf5nsw2 258 2 examples example NNS cord-261417-4pf5nsw2 258 3 that that WDT cord-261417-4pf5nsw2 258 4 follow follow VBP cord-261417-4pf5nsw2 258 5 the the DT cord-261417-4pf5nsw2 258 6 same same JJ cord-261417-4pf5nsw2 258 7 strategy strategy NN cord-261417-4pf5nsw2 258 8 include include VBP cord-261417-4pf5nsw2 258 9 rotaviruses rotaviruses NNP cord-261417-4pf5nsw2 258 10 [ [ -LRB- cord-261417-4pf5nsw2 258 11 121 121 CD cord-261417-4pf5nsw2 258 12 ] ] -RRB- cord-261417-4pf5nsw2 258 13 , , , cord-261417-4pf5nsw2 258 14 barley barley NN cord-261417-4pf5nsw2 258 15 yellow yellow JJ cord-261417-4pf5nsw2 258 16 dwarf dwarf NN cord-261417-4pf5nsw2 258 17 virus virus NN cord-261417-4pf5nsw2 258 18 [ [ -LRB- cord-261417-4pf5nsw2 258 19 122 122 CD cord-261417-4pf5nsw2 258 20 ] ] -RRB- cord-261417-4pf5nsw2 258 21 , , , cord-261417-4pf5nsw2 258 22 and and CC cord-261417-4pf5nsw2 258 23 possibly possibly RB cord-261417-4pf5nsw2 258 24 hepatitis hepatitis NNP cord-261417-4pf5nsw2 258 25 C C NNP cord-261417-4pf5nsw2 258 26 virus virus NN cord-261417-4pf5nsw2 258 27 [ [ -LRB- cord-261417-4pf5nsw2 258 28 123 123 CD cord-261417-4pf5nsw2 258 29 ] ] -RRB- cord-261417-4pf5nsw2 258 30 . . . cord-261417-4pf5nsw2 259 1 Additionally additionally RB cord-261417-4pf5nsw2 259 2 , , , cord-261417-4pf5nsw2 259 3 premature premature JJ cord-261417-4pf5nsw2 259 4 transcription transcription NN cord-261417-4pf5nsw2 259 5 termination termination NN cord-261417-4pf5nsw2 259 6 events event NNS cord-261417-4pf5nsw2 259 7 are be VBP cord-261417-4pf5nsw2 259 8 being be VBG cord-261417-4pf5nsw2 259 9 uncovered uncover VBN cord-261417-4pf5nsw2 259 10 that that WDT cord-261417-4pf5nsw2 259 11 allow allow VBP cord-261417-4pf5nsw2 259 12 viruses virus NNS cord-261417-4pf5nsw2 259 13 to to TO cord-261417-4pf5nsw2 259 14 produce produce VB cord-261417-4pf5nsw2 259 15 another another DT cord-261417-4pf5nsw2 259 16 layer layer NN cord-261417-4pf5nsw2 259 17 of of IN cord-261417-4pf5nsw2 259 18 transcripts transcript NNS cord-261417-4pf5nsw2 259 19 encoded encode VBN cord-261417-4pf5nsw2 259 20 by by IN cord-261417-4pf5nsw2 259 21 the the DT cord-261417-4pf5nsw2 259 22 same same JJ cord-261417-4pf5nsw2 259 23 genome genome NN cord-261417-4pf5nsw2 259 24 . . . cord-261417-4pf5nsw2 260 1 By by IN cord-261417-4pf5nsw2 260 2 using use VBG cord-261417-4pf5nsw2 260 3 these these DT cord-261417-4pf5nsw2 260 4 sub sub JJ cord-261417-4pf5nsw2 260 5 - - JJ cord-261417-4pf5nsw2 260 6 genomic genomic JJ cord-261417-4pf5nsw2 260 7 transcripts transcript NNS cord-261417-4pf5nsw2 260 8 , , , cord-261417-4pf5nsw2 260 9 viruses virus NNS cord-261417-4pf5nsw2 260 10 can can MD cord-261417-4pf5nsw2 260 11 create create VB cord-261417-4pf5nsw2 260 12 regulatory regulatory JJ cord-261417-4pf5nsw2 260 13 RNA RNA NNP cord-261417-4pf5nsw2 260 14 molecules molecule NNS cord-261417-4pf5nsw2 260 15 that that WDT cord-261417-4pf5nsw2 260 16 undergo undergo VBP cord-261417-4pf5nsw2 260 17 a a DT cord-261417-4pf5nsw2 260 18 different different JJ cord-261417-4pf5nsw2 260 19 fate fate NN cord-261417-4pf5nsw2 260 20 than than IN cord-261417-4pf5nsw2 260 21 the the DT cord-261417-4pf5nsw2 260 22 main main JJ cord-261417-4pf5nsw2 260 23 vRNA vrna NN cord-261417-4pf5nsw2 260 24 . . . cord-261417-4pf5nsw2 261 1 This this DT cord-261417-4pf5nsw2 261 2 can can MD cord-261417-4pf5nsw2 261 3 for for IN cord-261417-4pf5nsw2 261 4 instance instance NN cord-261417-4pf5nsw2 261 5 be be VB cord-261417-4pf5nsw2 261 6 miRNA miRNA NNP cord-261417-4pf5nsw2 261 7 production production NN cord-261417-4pf5nsw2 261 8 by by IN cord-261417-4pf5nsw2 261 9 retroviruses retrovirus NNS cord-261417-4pf5nsw2 261 10 [ [ -LRB- cord-261417-4pf5nsw2 261 11 6 6 CD cord-261417-4pf5nsw2 261 12 ] ] -RRB- cord-261417-4pf5nsw2 261 13 or or CC cord-261417-4pf5nsw2 262 1 the the DT cord-261417-4pf5nsw2 262 2 above above RB cord-261417-4pf5nsw2 262 3 described describe VBN cord-261417-4pf5nsw2 262 4 EBER EBER NNP cord-261417-4pf5nsw2 262 5 small small JJ cord-261417-4pf5nsw2 262 6 ncRNAs ncRNAs NNPS cord-261417-4pf5nsw2 262 7 produced produce VBN cord-261417-4pf5nsw2 262 8 by by IN cord-261417-4pf5nsw2 262 9 EBV EBV NNP cord-261417-4pf5nsw2 262 10 . . . cord-261417-4pf5nsw2 263 1 Retroviruses retrovirus NNS cord-261417-4pf5nsw2 263 2 have have VBP cord-261417-4pf5nsw2 263 3 to to TO cord-261417-4pf5nsw2 263 4 produce produce VB cord-261417-4pf5nsw2 263 5 an an DT cord-261417-4pf5nsw2 263 6 alternative alternative JJ cord-261417-4pf5nsw2 263 7 transcript transcript NN cord-261417-4pf5nsw2 263 8 as as IN cord-261417-4pf5nsw2 263 9 a a DT cord-261417-4pf5nsw2 263 10 miRNA miRNA NNP cord-261417-4pf5nsw2 263 11 - - HYPH cord-261417-4pf5nsw2 263 12 source source NN cord-261417-4pf5nsw2 263 13 to to TO cord-261417-4pf5nsw2 263 14 prevent prevent VB cord-261417-4pf5nsw2 263 15 cleavage cleavage NN cord-261417-4pf5nsw2 263 16 of of IN cord-261417-4pf5nsw2 263 17 the the DT cord-261417-4pf5nsw2 263 18 vRNA vrna JJ cord-261417-4pf5nsw2 263 19 genome genome NN cord-261417-4pf5nsw2 263 20 during during IN cord-261417-4pf5nsw2 263 21 miRNA miRNA NNP cord-261417-4pf5nsw2 263 22 processing processing NN cord-261417-4pf5nsw2 263 23 by by IN cord-261417-4pf5nsw2 263 24 the the DT cord-261417-4pf5nsw2 263 25 Microprocessor Microprocessor NNP cord-261417-4pf5nsw2 263 26 complex complex NN cord-261417-4pf5nsw2 263 27 [ [ -LRB- cord-261417-4pf5nsw2 263 28 6 6 CD cord-261417-4pf5nsw2 263 29 , , , cord-261417-4pf5nsw2 263 30 124 124 CD cord-261417-4pf5nsw2 263 31 ] ] -RRB- cord-261417-4pf5nsw2 263 32 . . . cord-261417-4pf5nsw2 264 1 Most Most JJS cord-261417-4pf5nsw2 264 2 of of IN cord-261417-4pf5nsw2 264 3 these these DT cord-261417-4pf5nsw2 264 4 sub sub JJ cord-261417-4pf5nsw2 264 5 - - JJ cord-261417-4pf5nsw2 264 6 genomic genomic JJ cord-261417-4pf5nsw2 264 7 transcripts transcript NNS cord-261417-4pf5nsw2 264 8 are be VBP cord-261417-4pf5nsw2 264 9 RNAPIII RNAPIII NNP cord-261417-4pf5nsw2 264 10 - - HYPH cord-261417-4pf5nsw2 264 11 encoded encode VBN cord-261417-4pf5nsw2 264 12 [ [ -LRB- cord-261417-4pf5nsw2 264 13 125 125 CD cord-261417-4pf5nsw2 264 14 , , , cord-261417-4pf5nsw2 264 15 126 126 CD cord-261417-4pf5nsw2 264 16 ] ] -RRB- cord-261417-4pf5nsw2 264 17 , , , cord-261417-4pf5nsw2 264 18 but but CC cord-261417-4pf5nsw2 264 19 can can MD cord-261417-4pf5nsw2 264 20 also also RB cord-261417-4pf5nsw2 264 21 result result VB cord-261417-4pf5nsw2 264 22 from from IN cord-261417-4pf5nsw2 264 23 transcription transcription NN cord-261417-4pf5nsw2 264 24 termination termination NN cord-261417-4pf5nsw2 264 25 of of IN cord-261417-4pf5nsw2 264 26 promoter promoter NN cord-261417-4pf5nsw2 264 27 - - HYPH cord-261417-4pf5nsw2 264 28 proximal proximal JJ cord-261417-4pf5nsw2 264 29 paused pause VBD cord-261417-4pf5nsw2 264 30 RNAPII RNAPII NNP cord-261417-4pf5nsw2 264 31 [ [ -LRB- cord-261417-4pf5nsw2 264 32 127 127 CD cord-261417-4pf5nsw2 264 33 ] ] -RRB- cord-261417-4pf5nsw2 264 34 . . . cord-261417-4pf5nsw2 265 1 This this DT cord-261417-4pf5nsw2 265 2 nascent nascent JJ cord-261417-4pf5nsw2 265 3 RNA RNA NNP cord-261417-4pf5nsw2 265 4 will will MD cord-261417-4pf5nsw2 265 5 subsequently subsequently RB cord-261417-4pf5nsw2 265 6 be be VB cord-261417-4pf5nsw2 265 7 exported export VBN cord-261417-4pf5nsw2 265 8 to to IN cord-261417-4pf5nsw2 265 9 the the DT cord-261417-4pf5nsw2 265 10 cytoplasm cytoplasm NN cord-261417-4pf5nsw2 265 11 , , , cord-261417-4pf5nsw2 265 12 where where WRB cord-261417-4pf5nsw2 265 13 it -PRON- PRP cord-261417-4pf5nsw2 265 14 can can MD cord-261417-4pf5nsw2 265 15 enter enter VB cord-261417-4pf5nsw2 265 16 the the DT cord-261417-4pf5nsw2 265 17 RNAi RNAi NNP cord-261417-4pf5nsw2 265 18 pathway pathway NN cord-261417-4pf5nsw2 265 19 at at IN cord-261417-4pf5nsw2 265 20 the the DT cord-261417-4pf5nsw2 265 21 Dicer Dicer NNP cord-261417-4pf5nsw2 265 22 step step NN cord-261417-4pf5nsw2 265 23 . . . cord-261417-4pf5nsw2 266 1 Viruses virus NNS cord-261417-4pf5nsw2 266 2 can can MD cord-261417-4pf5nsw2 266 3 downregulate downregulate VB cord-261417-4pf5nsw2 266 4 host host NN cord-261417-4pf5nsw2 266 5 transcription transcription NN cord-261417-4pf5nsw2 266 6 by by IN cord-261417-4pf5nsw2 266 7 targeted target VBN cord-261417-4pf5nsw2 266 8 mRNA mRNA NNP cord-261417-4pf5nsw2 266 9 degradation degradation NN cord-261417-4pf5nsw2 266 10 , , , cord-261417-4pf5nsw2 266 11 to to TO cord-261417-4pf5nsw2 266 12 benefit benefit VB cord-261417-4pf5nsw2 266 13 their -PRON- PRP$ cord-261417-4pf5nsw2 266 14 own own JJ cord-261417-4pf5nsw2 266 15 gene gene NN cord-261417-4pf5nsw2 266 16 expression expression NN cord-261417-4pf5nsw2 266 17 . . . cord-261417-4pf5nsw2 267 1 In in IN cord-261417-4pf5nsw2 267 2 this this DT cord-261417-4pf5nsw2 267 3 way way NN cord-261417-4pf5nsw2 267 4 , , , cord-261417-4pf5nsw2 267 5 the the DT cord-261417-4pf5nsw2 267 6 host host NN cord-261417-4pf5nsw2 267 7 transcription transcription NN cord-261417-4pf5nsw2 267 8 machinery machinery NN cord-261417-4pf5nsw2 267 9 is be VBZ cord-261417-4pf5nsw2 267 10 deprived deprive VBN cord-261417-4pf5nsw2 267 11 of of IN cord-261417-4pf5nsw2 267 12 targets target NNS cord-261417-4pf5nsw2 267 13 and and CC cord-261417-4pf5nsw2 267 14 the the DT cord-261417-4pf5nsw2 267 15 virus virus NN cord-261417-4pf5nsw2 267 16 can can MD cord-261417-4pf5nsw2 267 17 redirect redirect VB cord-261417-4pf5nsw2 267 18 the the DT cord-261417-4pf5nsw2 267 19 machinery machinery NN cord-261417-4pf5nsw2 267 20 to to IN cord-261417-4pf5nsw2 267 21 its -PRON- PRP$ cord-261417-4pf5nsw2 267 22 own own JJ cord-261417-4pf5nsw2 267 23 viral viral JJ cord-261417-4pf5nsw2 267 24 expression expression NN cord-261417-4pf5nsw2 267 25 . . . cord-261417-4pf5nsw2 268 1 As as IN cord-261417-4pf5nsw2 268 2 a a DT cord-261417-4pf5nsw2 268 3 beneficial beneficial JJ cord-261417-4pf5nsw2 268 4 side side NN cord-261417-4pf5nsw2 268 5 - - HYPH cord-261417-4pf5nsw2 268 6 effect effect NN cord-261417-4pf5nsw2 268 7 to to IN cord-261417-4pf5nsw2 268 8 the the DT cord-261417-4pf5nsw2 268 9 virus virus NN cord-261417-4pf5nsw2 268 10 , , , cord-261417-4pf5nsw2 268 11 lowering lower VBG cord-261417-4pf5nsw2 268 12 host host NN cord-261417-4pf5nsw2 268 13 transcription transcription NN cord-261417-4pf5nsw2 268 14 will will MD cord-261417-4pf5nsw2 268 15 also also RB cord-261417-4pf5nsw2 268 16 reduce reduce VB cord-261417-4pf5nsw2 268 17 the the DT cord-261417-4pf5nsw2 268 18 effectiveness effectiveness NN cord-261417-4pf5nsw2 268 19 of of IN cord-261417-4pf5nsw2 268 20 the the DT cord-261417-4pf5nsw2 268 21 immune immune JJ cord-261417-4pf5nsw2 268 22 system system NN cord-261417-4pf5nsw2 268 23 . . . cord-261417-4pf5nsw2 269 1 Therefore therefore RB cord-261417-4pf5nsw2 269 2 , , , cord-261417-4pf5nsw2 269 3 during during IN cord-261417-4pf5nsw2 269 4 infection infection NN cord-261417-4pf5nsw2 269 5 with with IN cord-261417-4pf5nsw2 269 6 many many JJ cord-261417-4pf5nsw2 269 7 human human JJ cord-261417-4pf5nsw2 269 8 viruses virus NNS cord-261417-4pf5nsw2 269 9 , , , cord-261417-4pf5nsw2 269 10 the the DT cord-261417-4pf5nsw2 269 11 accumulation accumulation NN cord-261417-4pf5nsw2 269 12 of of IN cord-261417-4pf5nsw2 269 13 viral viral JJ cord-261417-4pf5nsw2 269 14 proteins protein NNS cord-261417-4pf5nsw2 269 15 is be VBZ cord-261417-4pf5nsw2 269 16 accompanied accompany VBN cord-261417-4pf5nsw2 269 17 by by IN cord-261417-4pf5nsw2 269 18 a a DT cord-261417-4pf5nsw2 269 19 progressive progressive JJ cord-261417-4pf5nsw2 269 20 global global JJ cord-261417-4pf5nsw2 269 21 reduction reduction NN cord-261417-4pf5nsw2 269 22 in in IN cord-261417-4pf5nsw2 269 23 the the DT cord-261417-4pf5nsw2 269 24 production production NN cord-261417-4pf5nsw2 269 25 of of IN cord-261417-4pf5nsw2 269 26 host host NN cord-261417-4pf5nsw2 269 27 proteins protein NNS cord-261417-4pf5nsw2 269 28 , , , cord-261417-4pf5nsw2 269 29 a a DT cord-261417-4pf5nsw2 269 30 phenomenon phenomenon NN cord-261417-4pf5nsw2 269 31 that that WDT cord-261417-4pf5nsw2 269 32 has have VBZ cord-261417-4pf5nsw2 269 33 been be VBN cord-261417-4pf5nsw2 269 34 termed term VBN cord-261417-4pf5nsw2 269 35 " " `` cord-261417-4pf5nsw2 269 36 host host NN cord-261417-4pf5nsw2 269 37 shutoff shutoff NN cord-261417-4pf5nsw2 269 38 " " '' cord-261417-4pf5nsw2 269 39 . . . cord-261417-4pf5nsw2 270 1 Viral viral JJ cord-261417-4pf5nsw2 270 2 factors factor NNS cord-261417-4pf5nsw2 270 3 that that WDT cord-261417-4pf5nsw2 270 4 can can MD cord-261417-4pf5nsw2 270 5 induce induce VB cord-261417-4pf5nsw2 270 6 host host NN cord-261417-4pf5nsw2 270 7 shutoff shutoff NN cord-261417-4pf5nsw2 270 8 include include VBP cord-261417-4pf5nsw2 270 9 severe severe JJ cord-261417-4pf5nsw2 270 10 acute acute JJ cord-261417-4pf5nsw2 270 11 respiratory respiratory JJ cord-261417-4pf5nsw2 270 12 syndrome syndrome NN cord-261417-4pf5nsw2 270 13 ( ( -LRB- cord-261417-4pf5nsw2 270 14 SARS SARS NNP cord-261417-4pf5nsw2 270 15 ) ) -RRB- cord-261417-4pf5nsw2 270 16 coronavirus coronavirus NN cord-261417-4pf5nsw2 270 17 nsp1 nsp1 CD cord-261417-4pf5nsw2 270 18 [ [ -LRB- cord-261417-4pf5nsw2 270 19 128 128 CD cord-261417-4pf5nsw2 270 20 , , , cord-261417-4pf5nsw2 270 21 129 129 CD cord-261417-4pf5nsw2 270 22 ] ] -RRB- cord-261417-4pf5nsw2 270 23 , , , cord-261417-4pf5nsw2 270 24 herpes herpes NN cord-261417-4pf5nsw2 270 25 simplex simplex NN cord-261417-4pf5nsw2 270 26 virus virus NN cord-261417-4pf5nsw2 270 27 1 1 CD cord-261417-4pf5nsw2 270 28 ( ( -LRB- cord-261417-4pf5nsw2 270 29 HSV-1 HSV-1 NNP cord-261417-4pf5nsw2 270 30 ) ) -RRB- cord-261417-4pf5nsw2 270 31 vhs vhs NNP cord-261417-4pf5nsw2 270 32 [ [ -LRB- cord-261417-4pf5nsw2 270 33 130 130 CD cord-261417-4pf5nsw2 270 34 , , , cord-261417-4pf5nsw2 270 35 131 131 CD cord-261417-4pf5nsw2 270 36 ] ] -RRB- cord-261417-4pf5nsw2 270 37 , , . cord-261417-4pf5nsw2 271 1 vaccinia vaccinia NN cord-261417-4pf5nsw2 271 2 encoded encode VBD cord-261417-4pf5nsw2 271 3 decapping decapping NN cord-261417-4pf5nsw2 271 4 nucleases nuclease NNS cord-261417-4pf5nsw2 271 5 D9 D9 NNP cord-261417-4pf5nsw2 271 6 and and CC cord-261417-4pf5nsw2 271 7 D10 D10 NNP cord-261417-4pf5nsw2 271 8 [ [ -LRB- cord-261417-4pf5nsw2 271 9 132 132 CD cord-261417-4pf5nsw2 271 10 ] ] -RRB- cord-261417-4pf5nsw2 272 1 [ [ -LRB- cord-261417-4pf5nsw2 272 2 133 133 CD cord-261417-4pf5nsw2 272 3 ] ] -RRB- cord-261417-4pf5nsw2 272 4 [ [ -LRB- cord-261417-4pf5nsw2 272 5 134 134 CD cord-261417-4pf5nsw2 272 6 ] ] -RRB- cord-261417-4pf5nsw2 272 7 , , , cord-261417-4pf5nsw2 272 8 and and CC cord-261417-4pf5nsw2 272 9 two two CD cord-261417-4pf5nsw2 272 10 recently recently RB cord-261417-4pf5nsw2 272 11 described describe VBD cord-261417-4pf5nsw2 272 12 viral viral JJ cord-261417-4pf5nsw2 272 13 endonucleases endonuclease NNS cord-261417-4pf5nsw2 272 14 : : : cord-261417-4pf5nsw2 272 15 Kaposi Kaposi NNP cord-261417-4pf5nsw2 272 16 's 's POS cord-261417-4pf5nsw2 272 17 sarcoma sarcoma NN cord-261417-4pf5nsw2 272 18 - - HYPH cord-261417-4pf5nsw2 272 19 associated associate VBN cord-261417-4pf5nsw2 272 20 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 272 21 ( ( -LRB- cord-261417-4pf5nsw2 272 22 KSHV KSHV NNP cord-261417-4pf5nsw2 272 23 ) ) -RRB- cord-261417-4pf5nsw2 272 24 SOX SOX NNP cord-261417-4pf5nsw2 272 25 [ [ -LRB- cord-261417-4pf5nsw2 272 26 135 135 CD cord-261417-4pf5nsw2 272 27 , , , cord-261417-4pf5nsw2 272 28 136 136 CD cord-261417-4pf5nsw2 272 29 ] ] -RRB- cord-261417-4pf5nsw2 272 30 and and CC cord-261417-4pf5nsw2 272 31 Influenza Influenza NNP cord-261417-4pf5nsw2 272 32 A A NNP cord-261417-4pf5nsw2 272 33 Virus virus NN cord-261417-4pf5nsw2 272 34 ( ( -LRB- cord-261417-4pf5nsw2 272 35 IAV IAV NNP cord-261417-4pf5nsw2 272 36 ) ) -RRB- cord-261417-4pf5nsw2 272 37 PA PA NNP cord-261417-4pf5nsw2 272 38 - - HYPH cord-261417-4pf5nsw2 272 39 X x NN cord-261417-4pf5nsw2 272 40 protein protein NN cord-261417-4pf5nsw2 272 41 [ [ -LRB- cord-261417-4pf5nsw2 272 42 137 137 CD cord-261417-4pf5nsw2 272 43 ] ] -RRB- cord-261417-4pf5nsw2 272 44 . . . cord-261417-4pf5nsw2 273 1 Like like IN cord-261417-4pf5nsw2 273 2 all all DT cord-261417-4pf5nsw2 273 3 influenza influenza NN cord-261417-4pf5nsw2 273 4 viruses virus NNS cord-261417-4pf5nsw2 273 5 , , , cord-261417-4pf5nsw2 273 6 IAV IAV NNP cord-261417-4pf5nsw2 273 7 is be VBZ cord-261417-4pf5nsw2 273 8 a a DT cord-261417-4pf5nsw2 273 9 segmented segmented JJ cord-261417-4pf5nsw2 273 10 negative negative JJ cord-261417-4pf5nsw2 273 11 strand strand NN cord-261417-4pf5nsw2 273 12 RNA RNA NNP cord-261417-4pf5nsw2 273 13 virus virus NN cord-261417-4pf5nsw2 273 14 . . . cord-261417-4pf5nsw2 274 1 The the DT cord-261417-4pf5nsw2 274 2 PA PA NNP cord-261417-4pf5nsw2 274 3 - - HYPH cord-261417-4pf5nsw2 274 4 X X NNP cord-261417-4pf5nsw2 274 5 protein protein NN cord-261417-4pf5nsw2 274 6 - - HYPH cord-261417-4pf5nsw2 274 7 encoding encode VBG cord-261417-4pf5nsw2 274 8 gene gene NN cord-261417-4pf5nsw2 274 9 overlaps overlap VBZ cord-261417-4pf5nsw2 274 10 with with IN cord-261417-4pf5nsw2 274 11 the the DT cord-261417-4pf5nsw2 274 12 open open JJ cord-261417-4pf5nsw2 274 13 reading reading NN cord-261417-4pf5nsw2 274 14 frame frame NN cord-261417-4pf5nsw2 274 15 ( ( -LRB- cord-261417-4pf5nsw2 274 16 ORF ORF NNP cord-261417-4pf5nsw2 274 17 ) ) -RRB- cord-261417-4pf5nsw2 274 18 for for IN cord-261417-4pf5nsw2 274 19 the the DT cord-261417-4pf5nsw2 274 20 PA PA NNP cord-261417-4pf5nsw2 274 21 FluPol FluPol NNP cord-261417-4pf5nsw2 274 22 subunit subunit NN cord-261417-4pf5nsw2 274 23 [ [ -LRB- cord-261417-4pf5nsw2 274 24 138 138 CD cord-261417-4pf5nsw2 274 25 ] ] -RRB- cord-261417-4pf5nsw2 274 26 . . . cord-261417-4pf5nsw2 275 1 Ribosomal Ribosomal NNP cord-261417-4pf5nsw2 275 2 frameshifting frameshifte VBG cord-261417-4pf5nsw2 275 3 on on IN cord-261417-4pf5nsw2 275 4 a a DT cord-261417-4pf5nsw2 275 5 rare rare JJ cord-261417-4pf5nsw2 275 6 CGU CGU NNP cord-261417-4pf5nsw2 275 7 codon codon NN cord-261417-4pf5nsw2 275 8 results result NNS cord-261417-4pf5nsw2 275 9 in in IN cord-261417-4pf5nsw2 275 10 a a DT cord-261417-4pf5nsw2 275 11 fusion fusion NN cord-261417-4pf5nsw2 275 12 protein protein NN cord-261417-4pf5nsw2 275 13 with with IN cord-261417-4pf5nsw2 275 14 the the DT cord-261417-4pf5nsw2 275 15 191-aa 191-aa CD cord-261417-4pf5nsw2 275 16 N N NNP cord-261417-4pf5nsw2 275 17 - - HYPH cord-261417-4pf5nsw2 275 18 terminal terminal NN cord-261417-4pf5nsw2 275 19 mRNA mrna NN cord-261417-4pf5nsw2 275 20 endonuclease endonuclease NN cord-261417-4pf5nsw2 275 21 domain domain NN cord-261417-4pf5nsw2 275 22 of of IN cord-261417-4pf5nsw2 275 23 PA PA NNP cord-261417-4pf5nsw2 275 24 and and CC cord-261417-4pf5nsw2 275 25 an an DT cord-261417-4pf5nsw2 275 26 alternative alternative JJ cord-261417-4pf5nsw2 275 27 C c NN cord-261417-4pf5nsw2 275 28 - - HYPH cord-261417-4pf5nsw2 275 29 terminal terminal NN cord-261417-4pf5nsw2 275 30 X x NN cord-261417-4pf5nsw2 275 31 domain domain NN cord-261417-4pf5nsw2 275 32 of of IN cord-261417-4pf5nsw2 275 33 either either DT cord-261417-4pf5nsw2 275 34 41 41 CD cord-261417-4pf5nsw2 275 35 or or CC cord-261417-4pf5nsw2 275 36 61 61 CD cord-261417-4pf5nsw2 275 37 aa aa NN cord-261417-4pf5nsw2 275 38 [ [ -LRB- cord-261417-4pf5nsw2 275 39 139 139 CD cord-261417-4pf5nsw2 275 40 , , , cord-261417-4pf5nsw2 275 41 140 140 CD cord-261417-4pf5nsw2 275 42 ] ] -RRB- cord-261417-4pf5nsw2 275 43 . . . cord-261417-4pf5nsw2 276 1 Consequently consequently RB cord-261417-4pf5nsw2 276 2 , , , cord-261417-4pf5nsw2 276 3 PA PA NNP cord-261417-4pf5nsw2 276 4 - - HYPH cord-261417-4pf5nsw2 276 5 X X NNP cord-261417-4pf5nsw2 276 6 lacks lack VBZ cord-261417-4pf5nsw2 276 7 the the DT cord-261417-4pf5nsw2 276 8 CTD CTD NNP cord-261417-4pf5nsw2 276 9 of of IN cord-261417-4pf5nsw2 276 10 PA PA NNP cord-261417-4pf5nsw2 276 11 responsible responsible JJ cord-261417-4pf5nsw2 276 12 for for IN cord-261417-4pf5nsw2 276 13 its -PRON- PRP$ cord-261417-4pf5nsw2 276 14 interaction interaction NN cord-261417-4pf5nsw2 276 15 with with IN cord-261417-4pf5nsw2 276 16 the the DT cord-261417-4pf5nsw2 276 17 PB1 pb1 JJ cord-261417-4pf5nsw2 276 18 subunit subunit NN cord-261417-4pf5nsw2 276 19 of of IN cord-261417-4pf5nsw2 276 20 FluPol FluPol NNP cord-261417-4pf5nsw2 276 21 , , , cord-261417-4pf5nsw2 276 22 and and CC cord-261417-4pf5nsw2 276 23 was be VBD cord-261417-4pf5nsw2 276 24 found find VBN cord-261417-4pf5nsw2 276 25 to to TO cord-261417-4pf5nsw2 276 26 share share VB cord-261417-4pf5nsw2 276 27 sequence sequence NN cord-261417-4pf5nsw2 276 28 similarity similarity NN cord-261417-4pf5nsw2 276 29 with with IN cord-261417-4pf5nsw2 276 30 the the DT cord-261417-4pf5nsw2 276 31 above above RB cord-261417-4pf5nsw2 276 32 described describe VBN cord-261417-4pf5nsw2 276 33 viral viral JJ cord-261417-4pf5nsw2 276 34 host host NN cord-261417-4pf5nsw2 276 35 shutoff shutoff NN cord-261417-4pf5nsw2 276 36 proteins protein NNS cord-261417-4pf5nsw2 276 37 that that WDT cord-261417-4pf5nsw2 276 38 trigger trigger VBP cord-261417-4pf5nsw2 276 39 RNA RNA NNP cord-261417-4pf5nsw2 276 40 degradation degradation NN cord-261417-4pf5nsw2 276 41 . . . cord-261417-4pf5nsw2 277 1 KSHV KSHV NNP cord-261417-4pf5nsw2 277 2 is be VBZ cord-261417-4pf5nsw2 277 3 a a DT cord-261417-4pf5nsw2 277 4 γ γ NN cord-261417-4pf5nsw2 277 5 - - HYPH cord-261417-4pf5nsw2 277 6 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 277 7 that that WDT cord-261417-4pf5nsw2 277 8 causes cause VBZ cord-261417-4pf5nsw2 277 9 tumors tumor NNS cord-261417-4pf5nsw2 277 10 of of IN cord-261417-4pf5nsw2 277 11 endothelial endothelial JJ cord-261417-4pf5nsw2 277 12 cells cell NNS cord-261417-4pf5nsw2 277 13 and and CC cord-261417-4pf5nsw2 277 14 B b NN cord-261417-4pf5nsw2 277 15 cells cell NNS cord-261417-4pf5nsw2 277 16 . . . cord-261417-4pf5nsw2 278 1 During during IN cord-261417-4pf5nsw2 278 2 lytic lytic JJ cord-261417-4pf5nsw2 278 3 infection infection NN cord-261417-4pf5nsw2 278 4 with with IN cord-261417-4pf5nsw2 278 5 KSHV KSHV NNP cord-261417-4pf5nsw2 278 6 , , , cord-261417-4pf5nsw2 278 7 global global JJ cord-261417-4pf5nsw2 278 8 degradation degradation NN cord-261417-4pf5nsw2 278 9 of of IN cord-261417-4pf5nsw2 278 10 host host NN cord-261417-4pf5nsw2 278 11 RNA RNA NNP cord-261417-4pf5nsw2 278 12 is be VBZ cord-261417-4pf5nsw2 278 13 triggered trigger VBN cord-261417-4pf5nsw2 278 14 by by IN cord-261417-4pf5nsw2 278 15 a a DT cord-261417-4pf5nsw2 278 16 virally virally RB cord-261417-4pf5nsw2 278 17 encoded encode VBN cord-261417-4pf5nsw2 278 18 protein protein NN cord-261417-4pf5nsw2 278 19 named name VBN cord-261417-4pf5nsw2 278 20 shutoff shutoff NN cord-261417-4pf5nsw2 278 21 and and CC cord-261417-4pf5nsw2 278 22 exonuclease exonuclease NN cord-261417-4pf5nsw2 278 23 ( ( -LRB- cord-261417-4pf5nsw2 278 24 SOX SOX NNP cord-261417-4pf5nsw2 278 25 ) ) -RRB- cord-261417-4pf5nsw2 278 26 [ [ -LRB- cord-261417-4pf5nsw2 278 27 135 135 CD cord-261417-4pf5nsw2 278 28 , , , cord-261417-4pf5nsw2 278 29 141 141 CD cord-261417-4pf5nsw2 278 30 , , , cord-261417-4pf5nsw2 278 31 142 142 CD cord-261417-4pf5nsw2 278 32 ] ] -RRB- cord-261417-4pf5nsw2 278 33 . . . cord-261417-4pf5nsw2 279 1 SOX SOX NNP cord-261417-4pf5nsw2 279 2 cleaves cleave VBZ cord-261417-4pf5nsw2 279 3 most most RBS cord-261417-4pf5nsw2 279 4 cellular cellular JJ cord-261417-4pf5nsw2 279 5 mRNAs mrna NNS cord-261417-4pf5nsw2 279 6 at at IN cord-261417-4pf5nsw2 279 7 random random JJ cord-261417-4pf5nsw2 279 8 positions position NNS cord-261417-4pf5nsw2 279 9 [ [ -LRB- cord-261417-4pf5nsw2 279 10 136 136 CD cord-261417-4pf5nsw2 279 11 , , , cord-261417-4pf5nsw2 279 12 143 143 CD cord-261417-4pf5nsw2 279 13 , , , cord-261417-4pf5nsw2 279 14 144 144 CD cord-261417-4pf5nsw2 279 15 ] ] -RRB- cord-261417-4pf5nsw2 279 16 . . . cord-261417-4pf5nsw2 280 1 Although although IN cord-261417-4pf5nsw2 280 2 the the DT cord-261417-4pf5nsw2 280 3 α α NN cord-261417-4pf5nsw2 280 4 - - HYPH cord-261417-4pf5nsw2 280 5 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 280 6 vhs vhs NN cord-261417-4pf5nsw2 280 7 and and CC cord-261417-4pf5nsw2 280 8 γ γ NN cord-261417-4pf5nsw2 280 9 - - HYPH cord-261417-4pf5nsw2 280 10 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 280 11 SOX SOX NNP cord-261417-4pf5nsw2 280 12 proteins protein NNS cord-261417-4pf5nsw2 280 13 are be VBP cord-261417-4pf5nsw2 280 14 not not RB cord-261417-4pf5nsw2 280 15 orthologs ortholog NNS cord-261417-4pf5nsw2 280 16 , , , cord-261417-4pf5nsw2 280 17 they -PRON- PRP cord-261417-4pf5nsw2 280 18 have have VBP cord-261417-4pf5nsw2 280 19 a a DT cord-261417-4pf5nsw2 280 20 similar similar JJ cord-261417-4pf5nsw2 280 21 mechanism mechanism NN cord-261417-4pf5nsw2 280 22 of of IN cord-261417-4pf5nsw2 280 23 action action NN cord-261417-4pf5nsw2 280 24 [ [ -LRB- cord-261417-4pf5nsw2 280 25 144 144 CD cord-261417-4pf5nsw2 280 26 ] ] -RRB- cord-261417-4pf5nsw2 280 27 ; ; : cord-261417-4pf5nsw2 280 28 both both DT cord-261417-4pf5nsw2 280 29 are be VBP cord-261417-4pf5nsw2 280 30 RNA RNA NNP cord-261417-4pf5nsw2 280 31 endonucleases endonuclease NNS cord-261417-4pf5nsw2 280 32 that that WDT cord-261417-4pf5nsw2 280 33 cut cut VBD cord-261417-4pf5nsw2 280 34 host host NN cord-261417-4pf5nsw2 280 35 mRNAs mrna VBD cord-261417-4pf5nsw2 280 36 into into IN cord-261417-4pf5nsw2 280 37 fragments fragment NNS cord-261417-4pf5nsw2 280 38 . . . cord-261417-4pf5nsw2 281 1 The the DT cord-261417-4pf5nsw2 281 2 initial initial JJ cord-261417-4pf5nsw2 281 3 cleavage cleavage NN cord-261417-4pf5nsw2 281 4 is be VBZ cord-261417-4pf5nsw2 281 5 followed follow VBN cord-261417-4pf5nsw2 281 6 by by IN cord-261417-4pf5nsw2 281 7 degradation degradation NN cord-261417-4pf5nsw2 281 8 of of IN cord-261417-4pf5nsw2 281 9 the the DT cord-261417-4pf5nsw2 281 10 RNA RNA NNP cord-261417-4pf5nsw2 281 11 body body NN cord-261417-4pf5nsw2 281 12 by by IN cord-261417-4pf5nsw2 281 13 the the DT cord-261417-4pf5nsw2 281 14 cellular cellular JJ cord-261417-4pf5nsw2 281 15 5 5 CD cord-261417-4pf5nsw2 281 16 -3 -3 NNP cord-261417-4pf5nsw2 281 17 exonuclease exonuclease NNP cord-261417-4pf5nsw2 281 18 XrnI XrnI NNP cord-261417-4pf5nsw2 281 19 and and CC cord-261417-4pf5nsw2 281 20 potentially potentially RB cord-261417-4pf5nsw2 281 21 other other JJ cord-261417-4pf5nsw2 281 22 enzymes enzyme NNS cord-261417-4pf5nsw2 281 23 [ [ -LRB- cord-261417-4pf5nsw2 281 24 136 136 CD cord-261417-4pf5nsw2 281 25 , , , cord-261417-4pf5nsw2 281 26 143 143 CD cord-261417-4pf5nsw2 281 27 ] ] -RRB- cord-261417-4pf5nsw2 281 28 . . . cord-261417-4pf5nsw2 282 1 This this DT cord-261417-4pf5nsw2 282 2 mechanism mechanism NN cord-261417-4pf5nsw2 282 3 is be VBZ cord-261417-4pf5nsw2 282 4 shared share VBN cord-261417-4pf5nsw2 282 5 by by IN cord-261417-4pf5nsw2 282 6 other other JJ cord-261417-4pf5nsw2 282 7 viruses virus NNS cord-261417-4pf5nsw2 282 8 with with IN cord-261417-4pf5nsw2 282 9 shutoff shutoff NN cord-261417-4pf5nsw2 282 10 - - HYPH cord-261417-4pf5nsw2 282 11 RNases RNases NNP cord-261417-4pf5nsw2 282 12 like like IN cord-261417-4pf5nsw2 282 13 PA PA NNP cord-261417-4pf5nsw2 282 14 - - HYPH cord-261417-4pf5nsw2 282 15 X X NNP cord-261417-4pf5nsw2 282 16 for for IN cord-261417-4pf5nsw2 282 17 IAV IAV NNP cord-261417-4pf5nsw2 282 18 and and CC cord-261417-4pf5nsw2 282 19 nsp1 nsp1 NNS cord-261417-4pf5nsw2 282 20 for for IN cord-261417-4pf5nsw2 282 21 SARS SARS NNP cord-261417-4pf5nsw2 282 22 [ [ -LRB- cord-261417-4pf5nsw2 282 23 137 137 CD cord-261417-4pf5nsw2 282 24 , , , cord-261417-4pf5nsw2 282 25 144 144 CD cord-261417-4pf5nsw2 282 26 , , , cord-261417-4pf5nsw2 282 27 145 145 CD cord-261417-4pf5nsw2 282 28 ] ] -RRB- cord-261417-4pf5nsw2 282 29 . . . cord-261417-4pf5nsw2 283 1 Moreover moreover RB cord-261417-4pf5nsw2 283 2 , , , cord-261417-4pf5nsw2 283 3 all all DT cord-261417-4pf5nsw2 283 4 known know VBN cord-261417-4pf5nsw2 283 5 viral viral JJ cord-261417-4pf5nsw2 283 6 host host NN cord-261417-4pf5nsw2 283 7 shutoff shutoff NN cord-261417-4pf5nsw2 283 8 - - HYPH cord-261417-4pf5nsw2 283 9 RNases RNases NNP cord-261417-4pf5nsw2 283 10 , , , cord-261417-4pf5nsw2 283 11 degrade degrade VB cord-261417-4pf5nsw2 283 12 mRNAs mrnas CD cord-261417-4pf5nsw2 283 13 transcribed transcribe VBN cord-261417-4pf5nsw2 283 14 by by IN cord-261417-4pf5nsw2 283 15 the the DT cord-261417-4pf5nsw2 283 16 cellular cellular JJ cord-261417-4pf5nsw2 283 17 RNAPII rnapii NN cord-261417-4pf5nsw2 283 18 complex complex NN cord-261417-4pf5nsw2 283 19 and and CC cord-261417-4pf5nsw2 283 20 spare spare JJ cord-261417-4pf5nsw2 283 21 ncRNAs ncrna NNS cord-261417-4pf5nsw2 283 22 transcribed transcribe VBN cord-261417-4pf5nsw2 283 23 by by IN cord-261417-4pf5nsw2 283 24 RNAPI RNAPI NNP cord-261417-4pf5nsw2 283 25 and and CC cord-261417-4pf5nsw2 283 26 RNAPIII RNAPIII NNP cord-261417-4pf5nsw2 283 27 [ [ -LRB- cord-261417-4pf5nsw2 283 28 137 137 CD cord-261417-4pf5nsw2 283 29 , , , cord-261417-4pf5nsw2 283 30 143 143 CD cord-261417-4pf5nsw2 283 31 , , , cord-261417-4pf5nsw2 283 32 144 144 CD cord-261417-4pf5nsw2 283 33 ] ] -RRB- cord-261417-4pf5nsw2 283 34 . . . cord-261417-4pf5nsw2 284 1 Notably notably RB cord-261417-4pf5nsw2 284 2 , , , cord-261417-4pf5nsw2 284 3 viral viral JJ cord-261417-4pf5nsw2 284 4 mRNA mrna NN cord-261417-4pf5nsw2 284 5 transcription transcription NN cord-261417-4pf5nsw2 284 6 escapes escape VBZ cord-261417-4pf5nsw2 284 7 from from IN cord-261417-4pf5nsw2 284 8 decay decay NN cord-261417-4pf5nsw2 284 9 - - HYPH cord-261417-4pf5nsw2 284 10 induced induce VBN cord-261417-4pf5nsw2 284 11 repression repression NN cord-261417-4pf5nsw2 284 12 , , , cord-261417-4pf5nsw2 284 13 and and CC cord-261417-4pf5nsw2 284 14 this this DT cord-261417-4pf5nsw2 284 15 escape escape NN cord-261417-4pf5nsw2 284 16 also also RB cord-261417-4pf5nsw2 284 17 relies rely VBZ cord-261417-4pf5nsw2 284 18 on on IN cord-261417-4pf5nsw2 284 19 XrnI. XrnI. NNP cord-261417-4pf5nsw2 285 1 However however RB cord-261417-4pf5nsw2 285 2 , , , cord-261417-4pf5nsw2 285 3 the the DT cord-261417-4pf5nsw2 285 4 mechanisms mechanism NNS cord-261417-4pf5nsw2 285 5 that that WDT cord-261417-4pf5nsw2 285 6 allow allow VBP cord-261417-4pf5nsw2 285 7 viral viral JJ cord-261417-4pf5nsw2 285 8 mRNAs mrnas CD cord-261417-4pf5nsw2 285 9 , , , cord-261417-4pf5nsw2 285 10 unlike unlike IN cord-261417-4pf5nsw2 285 11 cellular cellular JJ cord-261417-4pf5nsw2 285 12 mRNAs mRNAs NNPS cord-261417-4pf5nsw2 285 13 , , , cord-261417-4pf5nsw2 285 14 to to TO cord-261417-4pf5nsw2 285 15 escape escape VB cord-261417-4pf5nsw2 285 16 from from IN cord-261417-4pf5nsw2 285 17 XrnI XrnI NNP cord-261417-4pf5nsw2 285 18 cleavage cleavage NN cord-261417-4pf5nsw2 285 19 are be VBP cord-261417-4pf5nsw2 285 20 unknown unknown JJ cord-261417-4pf5nsw2 285 21 . . . cord-261417-4pf5nsw2 286 1 A a DT cord-261417-4pf5nsw2 286 2 complex complex JJ cord-261417-4pf5nsw2 286 3 interplay interplay NN cord-261417-4pf5nsw2 286 4 between between IN cord-261417-4pf5nsw2 286 5 viruses virus NNS cord-261417-4pf5nsw2 286 6 and and CC cord-261417-4pf5nsw2 286 7 the the DT cord-261417-4pf5nsw2 286 8 host host NN cord-261417-4pf5nsw2 286 9 transcription transcription NN cord-261417-4pf5nsw2 286 10 machinery machinery NN cord-261417-4pf5nsw2 286 11 that that WDT cord-261417-4pf5nsw2 286 12 is be VBZ cord-261417-4pf5nsw2 286 13 mediated mediate VBN cord-261417-4pf5nsw2 286 14 by by IN cord-261417-4pf5nsw2 286 15 nascent nascent JJ cord-261417-4pf5nsw2 286 16 RNA RNA NNP cord-261417-4pf5nsw2 286 17 has have VBZ cord-261417-4pf5nsw2 286 18 recently recently RB cord-261417-4pf5nsw2 286 19 become become VBN cord-261417-4pf5nsw2 286 20 increasingly increasingly RB cord-261417-4pf5nsw2 286 21 apparent apparent JJ cord-261417-4pf5nsw2 286 22 . . . cord-261417-4pf5nsw2 287 1 Here here RB cord-261417-4pf5nsw2 287 2 , , , cord-261417-4pf5nsw2 287 3 we -PRON- PRP cord-261417-4pf5nsw2 287 4 explored explore VBD cord-261417-4pf5nsw2 287 5 a a DT cord-261417-4pf5nsw2 287 6 few few JJ cord-261417-4pf5nsw2 287 7 of of IN cord-261417-4pf5nsw2 287 8 the the DT cord-261417-4pf5nsw2 287 9 myriad myriad JJ cord-261417-4pf5nsw2 287 10 pathways pathway NNS cord-261417-4pf5nsw2 287 11 by by IN cord-261417-4pf5nsw2 287 12 which which WDT cord-261417-4pf5nsw2 287 13 viruses virus NNS cord-261417-4pf5nsw2 287 14 ( ( -LRB- cord-261417-4pf5nsw2 287 15 i i NN cord-261417-4pf5nsw2 287 16 ) ) -RRB- cord-261417-4pf5nsw2 287 17 use use VBP cord-261417-4pf5nsw2 287 18 their -PRON- PRP$ cord-261417-4pf5nsw2 287 19 own own JJ cord-261417-4pf5nsw2 287 20 nascent nascent JJ cord-261417-4pf5nsw2 287 21 RNA RNA NNP cord-261417-4pf5nsw2 287 22 - - HYPH cord-261417-4pf5nsw2 287 23 in in IN cord-261417-4pf5nsw2 287 24 cis cis NNP cord-261417-4pf5nsw2 287 25 or or CC cord-261417-4pf5nsw2 287 26 in in IN cord-261417-4pf5nsw2 287 27 trans trans NNP cord-261417-4pf5nsw2 287 28 - - : cord-261417-4pf5nsw2 287 29 as as IN cord-261417-4pf5nsw2 287 30 a a DT cord-261417-4pf5nsw2 287 31 scaffold scaffold NN cord-261417-4pf5nsw2 287 32 to to TO cord-261417-4pf5nsw2 287 33 recruit recruit VB cord-261417-4pf5nsw2 287 34 host host NN cord-261417-4pf5nsw2 287 35 transcription transcription NN cord-261417-4pf5nsw2 287 36 factors factor NNS cord-261417-4pf5nsw2 287 37 ; ; , cord-261417-4pf5nsw2 287 38 ( ( -LRB- cord-261417-4pf5nsw2 287 39 ii ii NN cord-261417-4pf5nsw2 287 40 ) ) -RRB- cord-261417-4pf5nsw2 287 41 use use VBP cord-261417-4pf5nsw2 287 42 host host NN cord-261417-4pf5nsw2 287 43 - - HYPH cord-261417-4pf5nsw2 287 44 capped cap VBN cord-261417-4pf5nsw2 287 45 RNAs rna NNS cord-261417-4pf5nsw2 287 46 as as IN cord-261417-4pf5nsw2 287 47 primers primer NNS cord-261417-4pf5nsw2 287 48 for for IN cord-261417-4pf5nsw2 287 49 RNA RNA NNP cord-261417-4pf5nsw2 287 50 synthesis synthesis NN cord-261417-4pf5nsw2 287 51 ; ; , cord-261417-4pf5nsw2 287 52 ( ( -LRB- cord-261417-4pf5nsw2 287 53 iii iii NN cord-261417-4pf5nsw2 287 54 ) ) -RRB- cord-261417-4pf5nsw2 287 55 use use NN cord-261417-4pf5nsw2 287 56 termination termination NN cord-261417-4pf5nsw2 287 57 of of IN cord-261417-4pf5nsw2 287 58 nascent nascent JJ cord-261417-4pf5nsw2 287 59 RNA RNA NNP cord-261417-4pf5nsw2 287 60 synthesis synthesis NN cord-261417-4pf5nsw2 287 61 to to TO cord-261417-4pf5nsw2 287 62 create create VB cord-261417-4pf5nsw2 287 63 sub sub JJ cord-261417-4pf5nsw2 287 64 - - JJ cord-261417-4pf5nsw2 287 65 genomic genomic JJ cord-261417-4pf5nsw2 287 66 mRNAs mrna NNS cord-261417-4pf5nsw2 287 67 , , , cord-261417-4pf5nsw2 287 68 and and CC cord-261417-4pf5nsw2 287 69 ( ( -LRB- cord-261417-4pf5nsw2 287 70 iv iv LS cord-261417-4pf5nsw2 287 71 ) ) -RRB- cord-261417-4pf5nsw2 287 72 and and CC cord-261417-4pf5nsw2 287 73 down down RB cord-261417-4pf5nsw2 287 74 - - HYPH cord-261417-4pf5nsw2 287 75 regulate regulate VB cord-261417-4pf5nsw2 287 76 host host NN cord-261417-4pf5nsw2 287 77 nascent nascent JJ cord-261417-4pf5nsw2 287 78 RNA RNA NNP cord-261417-4pf5nsw2 287 79 production production NN cord-261417-4pf5nsw2 287 80 for for IN cord-261417-4pf5nsw2 287 81 their -PRON- PRP$ cord-261417-4pf5nsw2 287 82 own own JJ cord-261417-4pf5nsw2 287 83 benefit benefit NN cord-261417-4pf5nsw2 287 84 . . . cord-261417-4pf5nsw2 288 1 Viral Viral NNP cord-261417-4pf5nsw2 288 2 RNA RNA NNP cord-261417-4pf5nsw2 288 3 synthesis synthesis NN cord-261417-4pf5nsw2 288 4 pathways pathway NNS cord-261417-4pf5nsw2 288 5 are be VBP cord-261417-4pf5nsw2 288 6 promising promising JJ cord-261417-4pf5nsw2 288 7 targets target NNS cord-261417-4pf5nsw2 288 8 for for IN cord-261417-4pf5nsw2 288 9 antiviral antiviral JJ cord-261417-4pf5nsw2 288 10 development development NN cord-261417-4pf5nsw2 288 11 because because IN cord-261417-4pf5nsw2 288 12 these these DT cord-261417-4pf5nsw2 288 13 mechanisms mechanism NNS cord-261417-4pf5nsw2 288 14 are be VBP cord-261417-4pf5nsw2 288 15 essential essential JJ cord-261417-4pf5nsw2 288 16 for for IN cord-261417-4pf5nsw2 288 17 virus virus NN cord-261417-4pf5nsw2 288 18 replication replication NN cord-261417-4pf5nsw2 288 19 . . . cord-261417-4pf5nsw2 289 1 However however RB cord-261417-4pf5nsw2 289 2 , , , cord-261417-4pf5nsw2 289 3 in in IN cord-261417-4pf5nsw2 289 4 order order NN cord-261417-4pf5nsw2 289 5 to to TO cord-261417-4pf5nsw2 289 6 identify identify VB cord-261417-4pf5nsw2 289 7 additional additional JJ cord-261417-4pf5nsw2 289 8 weak weak JJ cord-261417-4pf5nsw2 289 9 spots spot NNS cord-261417-4pf5nsw2 289 10 in in IN cord-261417-4pf5nsw2 289 11 viral viral JJ cord-261417-4pf5nsw2 289 12 infection infection NN cord-261417-4pf5nsw2 289 13 programs program NNS cord-261417-4pf5nsw2 289 14 , , , cord-261417-4pf5nsw2 289 15 it -PRON- PRP cord-261417-4pf5nsw2 289 16 is be VBZ cord-261417-4pf5nsw2 289 17 important important JJ cord-261417-4pf5nsw2 289 18 to to TO cord-261417-4pf5nsw2 289 19 understand understand VB cord-261417-4pf5nsw2 289 20 how how WRB cord-261417-4pf5nsw2 289 21 viruses virus NNS cord-261417-4pf5nsw2 289 22 regulate regulate VBP cord-261417-4pf5nsw2 289 23 their -PRON- PRP$ cord-261417-4pf5nsw2 289 24 gene gene NN cord-261417-4pf5nsw2 289 25 expression expression NN cord-261417-4pf5nsw2 289 26 and and CC cord-261417-4pf5nsw2 289 27 to to TO cord-261417-4pf5nsw2 289 28 disentangle disentangle VB cord-261417-4pf5nsw2 289 29 the the DT cord-261417-4pf5nsw2 289 30 complex complex JJ cord-261417-4pf5nsw2 289 31 ways way NNS cord-261417-4pf5nsw2 289 32 in in IN cord-261417-4pf5nsw2 289 33 which which WDT cord-261417-4pf5nsw2 289 34 these these DT cord-261417-4pf5nsw2 289 35 pathways pathway NNS cord-261417-4pf5nsw2 289 36 are be VBP cord-261417-4pf5nsw2 289 37 intertwined intertwine VBN cord-261417-4pf5nsw2 289 38 with with IN cord-261417-4pf5nsw2 289 39 host host NN cord-261417-4pf5nsw2 289 40 transcription transcription NN cord-261417-4pf5nsw2 289 41 . . . cord-261417-4pf5nsw2 290 1 Many many JJ cord-261417-4pf5nsw2 290 2 antivirals antiviral NNS cord-261417-4pf5nsw2 290 3 display display VBP cord-261417-4pf5nsw2 290 4 adverse adverse JJ cord-261417-4pf5nsw2 290 5 side side NN cord-261417-4pf5nsw2 290 6 - - HYPH cord-261417-4pf5nsw2 290 7 effects effect NNS cord-261417-4pf5nsw2 290 8 because because IN cord-261417-4pf5nsw2 290 9 the the DT cord-261417-4pf5nsw2 290 10 viral viral JJ cord-261417-4pf5nsw2 290 11 target target NN cord-261417-4pf5nsw2 290 12 molecule molecule NN cord-261417-4pf5nsw2 290 13 and and CC cord-261417-4pf5nsw2 290 14 process process NN cord-261417-4pf5nsw2 290 15 was be VBD cord-261417-4pf5nsw2 290 16 incompletely incompletely RB cord-261417-4pf5nsw2 290 17 understood understand VBN cord-261417-4pf5nsw2 290 18 . . . cord-261417-4pf5nsw2 291 1 The the DT cord-261417-4pf5nsw2 291 2 recently recently RB cord-261417-4pf5nsw2 291 3 described describe VBN cord-261417-4pf5nsw2 291 4 new new JJ cord-261417-4pf5nsw2 291 5 insights insight NNS cord-261417-4pf5nsw2 291 6 into into IN cord-261417-4pf5nsw2 291 7 the the DT cord-261417-4pf5nsw2 291 8 roles role NNS cord-261417-4pf5nsw2 291 9 of of IN cord-261417-4pf5nsw2 291 10 nascent nascent JJ cord-261417-4pf5nsw2 291 11 RNA RNA NNP cord-261417-4pf5nsw2 291 12 in in IN cord-261417-4pf5nsw2 291 13 viral viral JJ cord-261417-4pf5nsw2 291 14 gene gene NN cord-261417-4pf5nsw2 291 15 regulation regulation NN cord-261417-4pf5nsw2 291 16 are be VBP cord-261417-4pf5nsw2 291 17 important important JJ cord-261417-4pf5nsw2 291 18 steps step NNS cord-261417-4pf5nsw2 291 19 in in IN cord-261417-4pf5nsw2 291 20 the the DT cord-261417-4pf5nsw2 291 21 path path NN cord-261417-4pf5nsw2 291 22 to to IN cord-261417-4pf5nsw2 291 23 new new JJ cord-261417-4pf5nsw2 291 24 , , , cord-261417-4pf5nsw2 291 25 more more RBR cord-261417-4pf5nsw2 291 26 effective effective JJ cord-261417-4pf5nsw2 291 27 antivirals antiviral NNS cord-261417-4pf5nsw2 291 28 with with IN cord-261417-4pf5nsw2 291 29 fewer few JJR cord-261417-4pf5nsw2 291 30 side side NN cord-261417-4pf5nsw2 291 31 - - HYPH cord-261417-4pf5nsw2 291 32 effects effect NNS cord-261417-4pf5nsw2 291 33 . . . cord-261417-4pf5nsw2 292 1 Genetic genetic JJ cord-261417-4pf5nsw2 292 2 conflicts conflict NNS cord-261417-4pf5nsw2 292 3 : : : cord-261417-4pf5nsw2 293 1 The the DT cord-261417-4pf5nsw2 293 2 usual usual JJ cord-261417-4pf5nsw2 293 3 suspects suspect NNS cord-261417-4pf5nsw2 293 4 and and CC cord-261417-4pf5nsw2 293 5 beyond beyond IN cord-261417-4pf5nsw2 293 6 Paleovirology Paleovirology NNP cord-261417-4pf5nsw2 293 7 - - HYPH cord-261417-4pf5nsw2 293 8 Modern modern JJ cord-261417-4pf5nsw2 293 9 consequences consequence NNS cord-261417-4pf5nsw2 293 10 of of IN cord-261417-4pf5nsw2 293 11 ancient ancient JJ cord-261417-4pf5nsw2 293 12 viruses virus NNS cord-261417-4pf5nsw2 293 13 Co co NN cord-261417-4pf5nsw2 293 14 - - NN cord-261417-4pf5nsw2 293 15 option option NN cord-261417-4pf5nsw2 293 16 of of IN cord-261417-4pf5nsw2 293 17 an an DT cord-261417-4pf5nsw2 293 18 endogenous endogenous JJ cord-261417-4pf5nsw2 293 19 retrovirus retrovirus NN cord-261417-4pf5nsw2 293 20 envelope envelope NN cord-261417-4pf5nsw2 293 21 for for IN cord-261417-4pf5nsw2 293 22 host host NN cord-261417-4pf5nsw2 293 23 defense defense NN cord-261417-4pf5nsw2 293 24 in in IN cord-261417-4pf5nsw2 293 25 hominid hominid JJ cord-261417-4pf5nsw2 293 26 ancestors ancestor NNS cord-261417-4pf5nsw2 293 27 Evolutionary evolutionary JJ cord-261417-4pf5nsw2 293 28 genomics genomic NNS cord-261417-4pf5nsw2 293 29 of of IN cord-261417-4pf5nsw2 293 30 nucleo nucleo JJ cord-261417-4pf5nsw2 293 31 - - JJ cord-261417-4pf5nsw2 293 32 cytoplasmic cytoplasmic JJ cord-261417-4pf5nsw2 293 33 large large JJ cord-261417-4pf5nsw2 293 34 DNA dna NN cord-261417-4pf5nsw2 293 35 viruses virus NNS cord-261417-4pf5nsw2 293 36 Viral viral JJ cord-261417-4pf5nsw2 293 37 - - HYPH cord-261417-4pf5nsw2 293 38 encoded encode VBN cord-261417-4pf5nsw2 293 39 enzymes enzyme NNS cord-261417-4pf5nsw2 293 40 that that WDT cord-261417-4pf5nsw2 293 41 target target VBP cord-261417-4pf5nsw2 293 42 host host NN cord-261417-4pf5nsw2 293 43 chromatin chromatin NN cord-261417-4pf5nsw2 293 44 functions function NNS cord-261417-4pf5nsw2 293 45 Retroviral Retroviral NNP cord-261417-4pf5nsw2 293 46 micrornas micrornas NNP cord-261417-4pf5nsw2 293 47 Mechanisms Mechanisms NNPS cord-261417-4pf5nsw2 293 48 of of IN cord-261417-4pf5nsw2 293 49 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 293 50 control control NN cord-261417-4pf5nsw2 293 51 Virus Virus NNP cord-261417-4pf5nsw2 293 52 meets meet VBZ cord-261417-4pf5nsw2 293 53 host host NN cord-261417-4pf5nsw2 293 54 microrna microrna NNP cord-261417-4pf5nsw2 293 55 : : : cord-261417-4pf5nsw2 294 1 The the DT cord-261417-4pf5nsw2 294 2 destroyer destroyer NN cord-261417-4pf5nsw2 294 3 , , , cord-261417-4pf5nsw2 294 4 the the DT cord-261417-4pf5nsw2 294 5 booster booster NN cord-261417-4pf5nsw2 294 6 , , , cord-261417-4pf5nsw2 294 7 the the DT cord-261417-4pf5nsw2 294 8 hijacker hijacker NN cord-261417-4pf5nsw2 294 9 DNA dna NN cord-261417-4pf5nsw2 294 10 - - HYPH cord-261417-4pf5nsw2 294 11 binding bind VBG cord-261417-4pf5nsw2 294 12 specificities specificity NNS cord-261417-4pf5nsw2 294 13 of of IN cord-261417-4pf5nsw2 294 14 human human JJ cord-261417-4pf5nsw2 294 15 transcription transcription NN cord-261417-4pf5nsw2 294 16 factors factor NNS cord-261417-4pf5nsw2 294 17 Sensing Sensing NNP cord-261417-4pf5nsw2 294 18 of of IN cord-261417-4pf5nsw2 294 19 RNA RNA NNP cord-261417-4pf5nsw2 294 20 viruses virus NNS cord-261417-4pf5nsw2 294 21 : : : cord-261417-4pf5nsw2 294 22 A a DT cord-261417-4pf5nsw2 294 23 review review NN cord-261417-4pf5nsw2 294 24 of of IN cord-261417-4pf5nsw2 294 25 innate innate JJ cord-261417-4pf5nsw2 294 26 immune immune JJ cord-261417-4pf5nsw2 294 27 receptors receptor NNS cord-261417-4pf5nsw2 294 28 involved involve VBN cord-261417-4pf5nsw2 294 29 in in IN cord-261417-4pf5nsw2 294 30 recognizing recognize VBG cord-261417-4pf5nsw2 294 31 RNA RNA NNP cord-261417-4pf5nsw2 294 32 virus virus NN cord-261417-4pf5nsw2 294 33 invasion invasion NN cord-261417-4pf5nsw2 294 34 Rna Rna NNP cord-261417-4pf5nsw2 294 35 function function NN cord-261417-4pf5nsw2 294 36 . . . cord-261417-4pf5nsw2 295 1 RNA RNA NNP cord-261417-4pf5nsw2 295 2 and and CC cord-261417-4pf5nsw2 295 3 dynamic dynamic JJ cord-261417-4pf5nsw2 295 4 nuclear nuclear JJ cord-261417-4pf5nsw2 295 5 organization organization NN cord-261417-4pf5nsw2 295 6 Structure Structure NNP cord-261417-4pf5nsw2 295 7 of of IN cord-261417-4pf5nsw2 295 8 eukaryotic eukaryotic JJ cord-261417-4pf5nsw2 295 9 RNA RNA NNP cord-261417-4pf5nsw2 295 10 polymerases polymerase NNS cord-261417-4pf5nsw2 295 11 Cracking crack VBG cord-261417-4pf5nsw2 295 12 the the DT cord-261417-4pf5nsw2 295 13 RNA RNA NNP cord-261417-4pf5nsw2 295 14 polymerase polymerase NN cord-261417-4pf5nsw2 295 15 II II NNP cord-261417-4pf5nsw2 295 16 CTD CTD NNP cord-261417-4pf5nsw2 295 17 code code NN cord-261417-4pf5nsw2 295 18 Function function NN cord-261417-4pf5nsw2 295 19 and and CC cord-261417-4pf5nsw2 295 20 control control NN cord-261417-4pf5nsw2 295 21 of of IN cord-261417-4pf5nsw2 295 22 RNA RNA NNP cord-261417-4pf5nsw2 295 23 polymerase polymerase NN cord-261417-4pf5nsw2 295 24 II II NNP cord-261417-4pf5nsw2 295 25 C c NN cord-261417-4pf5nsw2 295 26 - - HYPH cord-261417-4pf5nsw2 295 27 terminal terminal NN cord-261417-4pf5nsw2 295 28 domain domain NN cord-261417-4pf5nsw2 295 29 phosphorylation phosphorylation NN cord-261417-4pf5nsw2 295 30 in in IN cord-261417-4pf5nsw2 295 31 vertebrate vertebrate JJ cord-261417-4pf5nsw2 295 32 transcription transcription NN cord-261417-4pf5nsw2 295 33 and and CC cord-261417-4pf5nsw2 295 34 RNA RNA NNP cord-261417-4pf5nsw2 295 35 processing processing NN cord-261417-4pf5nsw2 295 36 Effect Effect NNP cord-261417-4pf5nsw2 295 37 of of IN cord-261417-4pf5nsw2 295 38 actinomycin actinomycin NNS cord-261417-4pf5nsw2 295 39 D D NNP cord-261417-4pf5nsw2 295 40 on on IN cord-261417-4pf5nsw2 295 41 cellular cellular JJ cord-261417-4pf5nsw2 295 42 nucleic nucleic JJ cord-261417-4pf5nsw2 295 43 acid acid NN cord-261417-4pf5nsw2 295 44 synthesis synthesis NN cord-261417-4pf5nsw2 295 45 and and CC cord-261417-4pf5nsw2 295 46 virus virus NN cord-261417-4pf5nsw2 295 47 production production NN cord-261417-4pf5nsw2 295 48 Tentative tentative JJ cord-261417-4pf5nsw2 295 49 identification identification NN cord-261417-4pf5nsw2 295 50 of of IN cord-261417-4pf5nsw2 295 51 RNA RNA NNP cord-261417-4pf5nsw2 295 52 - - HYPH cord-261417-4pf5nsw2 295 53 dependent dependent JJ cord-261417-4pf5nsw2 295 54 RNA RNA NNP cord-261417-4pf5nsw2 295 55 polymerases polymerase NNS cord-261417-4pf5nsw2 295 56 of of IN cord-261417-4pf5nsw2 295 57 dsRNA dsrna NN cord-261417-4pf5nsw2 295 58 viruses virus NNS cord-261417-4pf5nsw2 295 59 and and CC cord-261417-4pf5nsw2 295 60 their -PRON- PRP$ cord-261417-4pf5nsw2 295 61 relationship relationship NN cord-261417-4pf5nsw2 295 62 to to IN cord-261417-4pf5nsw2 295 63 positive positive JJ cord-261417-4pf5nsw2 295 64 strand strand NN cord-261417-4pf5nsw2 295 65 RNA RNA NNP cord-261417-4pf5nsw2 295 66 viral viral JJ cord-261417-4pf5nsw2 295 67 polymerases polymerase NNS cord-261417-4pf5nsw2 296 1 A a DT cord-261417-4pf5nsw2 296 2 reevaluation reevaluation NN cord-261417-4pf5nsw2 296 3 of of IN cord-261417-4pf5nsw2 296 4 the the DT cord-261417-4pf5nsw2 296 5 higher high JJR cord-261417-4pf5nsw2 296 6 taxonomy taxonomy NN cord-261417-4pf5nsw2 296 7 of of IN cord-261417-4pf5nsw2 296 8 viruses virus NNS cord-261417-4pf5nsw2 296 9 based base VBN cord-261417-4pf5nsw2 296 10 on on IN cord-261417-4pf5nsw2 296 11 RNA RNA NNP cord-261417-4pf5nsw2 296 12 polymerases polymerase NNS cord-261417-4pf5nsw2 297 1 Elongation elongation NN cord-261417-4pf5nsw2 297 2 - - HYPH cord-261417-4pf5nsw2 297 3 competent competent JJ cord-261417-4pf5nsw2 297 4 pauses pause NNS cord-261417-4pf5nsw2 297 5 govern govern VBP cord-261417-4pf5nsw2 297 6 the the DT cord-261417-4pf5nsw2 297 7 fidelity fidelity NN cord-261417-4pf5nsw2 297 8 of of IN cord-261417-4pf5nsw2 297 9 a a DT cord-261417-4pf5nsw2 297 10 viral viral JJ cord-261417-4pf5nsw2 297 11 RNA rna NN cord-261417-4pf5nsw2 297 12 - - HYPH cord-261417-4pf5nsw2 297 13 dependent dependent JJ cord-261417-4pf5nsw2 297 14 RNA RNA NNP cord-261417-4pf5nsw2 297 15 polymerase polymerase NN cord-261417-4pf5nsw2 297 16 Assembly Assembly NNP cord-261417-4pf5nsw2 297 17 , , , cord-261417-4pf5nsw2 297 18 purification purification NN cord-261417-4pf5nsw2 297 19 , , , cord-261417-4pf5nsw2 297 20 and and CC cord-261417-4pf5nsw2 297 21 pre pre JJ cord-261417-4pf5nsw2 297 22 - - JJ cord-261417-4pf5nsw2 297 23 steady steady JJ cord-261417-4pf5nsw2 297 24 - - HYPH cord-261417-4pf5nsw2 297 25 state state NN cord-261417-4pf5nsw2 297 26 kinetic kinetic JJ cord-261417-4pf5nsw2 297 27 analysis analysis NN cord-261417-4pf5nsw2 297 28 of of IN cord-261417-4pf5nsw2 297 29 active active JJ cord-261417-4pf5nsw2 297 30 RNA RNA NNP cord-261417-4pf5nsw2 297 31 - - HYPH cord-261417-4pf5nsw2 297 32 dependent dependent JJ cord-261417-4pf5nsw2 297 33 RNA RNA NNP cord-261417-4pf5nsw2 297 34 polymerase polymerase NN cord-261417-4pf5nsw2 297 35 elongation elongation NN cord-261417-4pf5nsw2 297 36 complex complex JJ cord-261417-4pf5nsw2 297 37 De de FW cord-261417-4pf5nsw2 297 38 novo novo NN cord-261417-4pf5nsw2 297 39 initiation initiation NN cord-261417-4pf5nsw2 297 40 of of IN cord-261417-4pf5nsw2 297 41 viral viral JJ cord-261417-4pf5nsw2 297 42 RNA RNA NNP cord-261417-4pf5nsw2 297 43 - - HYPH cord-261417-4pf5nsw2 297 44 dependent dependent JJ cord-261417-4pf5nsw2 297 45 RNA RNA NNP cord-261417-4pf5nsw2 297 46 synthesis synthesis NN cord-261417-4pf5nsw2 297 47 Structural structural JJ cord-261417-4pf5nsw2 297 48 basis basis NN cord-261417-4pf5nsw2 297 49 of of IN cord-261417-4pf5nsw2 297 50 transcription transcription NN cord-261417-4pf5nsw2 297 51 initiation initiation NN cord-261417-4pf5nsw2 297 52 by by IN cord-261417-4pf5nsw2 297 53 RNA RNA NNP cord-261417-4pf5nsw2 297 54 polymerase polymerase NN cord-261417-4pf5nsw2 297 55 II II NNP cord-261417-4pf5nsw2 297 56 Structural structural JJ cord-261417-4pf5nsw2 297 57 insights insight NNS cord-261417-4pf5nsw2 297 58 into into IN cord-261417-4pf5nsw2 297 59 transcription transcription NN cord-261417-4pf5nsw2 297 60 initiation initiation NN cord-261417-4pf5nsw2 297 61 by by IN cord-261417-4pf5nsw2 297 62 RNA RNA NNP cord-261417-4pf5nsw2 297 63 polymerase polymerase NN cord-261417-4pf5nsw2 297 64 II II NNP cord-261417-4pf5nsw2 297 65 Structure structure NN cord-261417-4pf5nsw2 297 66 and and CC cord-261417-4pf5nsw2 297 67 function function NN cord-261417-4pf5nsw2 297 68 of of IN cord-261417-4pf5nsw2 297 69 a a DT cord-261417-4pf5nsw2 297 70 human human JJ cord-261417-4pf5nsw2 297 71 transcription transcription NN cord-261417-4pf5nsw2 297 72 factor factor NN cord-261417-4pf5nsw2 297 73 TFIIIB TFIIIB NNP cord-261417-4pf5nsw2 297 74 subunit subunit NN cord-261417-4pf5nsw2 297 75 that that WDT cord-261417-4pf5nsw2 297 76 is be VBZ cord-261417-4pf5nsw2 297 77 evolutionarily evolutionarily RB cord-261417-4pf5nsw2 297 78 conserved conserve VBN cord-261417-4pf5nsw2 297 79 and and CC cord-261417-4pf5nsw2 297 80 contains contain VBZ cord-261417-4pf5nsw2 297 81 both both DT cord-261417-4pf5nsw2 297 82 TFIIB TFIIB NNP cord-261417-4pf5nsw2 297 83 - - HYPH cord-261417-4pf5nsw2 297 84 and and CC cord-261417-4pf5nsw2 297 85 high high JJ cord-261417-4pf5nsw2 297 86 - - HYPH cord-261417-4pf5nsw2 297 87 mobility mobility NN cord-261417-4pf5nsw2 297 88 - - HYPH cord-261417-4pf5nsw2 297 89 group group NN cord-261417-4pf5nsw2 297 90 protein protein NN cord-261417-4pf5nsw2 297 91 2-related 2-related CD cord-261417-4pf5nsw2 297 92 domains domain NNS cord-261417-4pf5nsw2 297 93 Control Control NNP cord-261417-4pf5nsw2 297 94 of of IN cord-261417-4pf5nsw2 297 95 gene gene NN cord-261417-4pf5nsw2 297 96 expression expression NN cord-261417-4pf5nsw2 297 97 through through IN cord-261417-4pf5nsw2 297 98 regulation regulation NN cord-261417-4pf5nsw2 297 99 of of IN cord-261417-4pf5nsw2 297 100 the the DT cord-261417-4pf5nsw2 297 101 TATA TATA NNP cord-261417-4pf5nsw2 297 102 - - HYPH cord-261417-4pf5nsw2 297 103 binding bind VBG cord-261417-4pf5nsw2 297 104 protein protein NN cord-261417-4pf5nsw2 298 1 The the DT cord-261417-4pf5nsw2 298 2 basal basal NN cord-261417-4pf5nsw2 298 3 initiation initiation NN cord-261417-4pf5nsw2 298 4 machinery machinery NN cord-261417-4pf5nsw2 298 5 : : : cord-261417-4pf5nsw2 299 1 Beyond beyond IN cord-261417-4pf5nsw2 299 2 the the DT cord-261417-4pf5nsw2 299 3 general general JJ cord-261417-4pf5nsw2 299 4 transcription transcription NN cord-261417-4pf5nsw2 299 5 factors factor NNS cord-261417-4pf5nsw2 299 6 Isolation Isolation NNP cord-261417-4pf5nsw2 299 7 of of IN cord-261417-4pf5nsw2 299 8 coactivators coactivator NNS cord-261417-4pf5nsw2 299 9 associated associate VBN cord-261417-4pf5nsw2 299 10 with with IN cord-261417-4pf5nsw2 299 11 the the DT cord-261417-4pf5nsw2 299 12 TATA TATA NNP cord-261417-4pf5nsw2 299 13 - - HYPH cord-261417-4pf5nsw2 299 14 binding bind VBG cord-261417-4pf5nsw2 299 15 protein protein NN cord-261417-4pf5nsw2 299 16 that that WDT cord-261417-4pf5nsw2 299 17 mediate mediate VBP cord-261417-4pf5nsw2 299 18 transcriptional transcriptional JJ cord-261417-4pf5nsw2 299 19 activation activation NN cord-261417-4pf5nsw2 300 1 The the DT cord-261417-4pf5nsw2 300 2 general general JJ cord-261417-4pf5nsw2 300 3 transcription transcription NN cord-261417-4pf5nsw2 300 4 machinery machinery NN cord-261417-4pf5nsw2 300 5 and and CC cord-261417-4pf5nsw2 300 6 general general JJ cord-261417-4pf5nsw2 300 7 cofactors cofactor NNS cord-261417-4pf5nsw2 300 8 Architecture Architecture NNP cord-261417-4pf5nsw2 300 9 of of IN cord-261417-4pf5nsw2 300 10 an an DT cord-261417-4pf5nsw2 300 11 RNA RNA NNP cord-261417-4pf5nsw2 300 12 polymerase polymerase NN cord-261417-4pf5nsw2 300 13 II II NNP cord-261417-4pf5nsw2 300 14 transcription transcription NN cord-261417-4pf5nsw2 300 15 pre pre NN cord-261417-4pf5nsw2 300 16 - - JJ cord-261417-4pf5nsw2 300 17 initiation initiation JJ cord-261417-4pf5nsw2 300 18 complex complex JJ cord-261417-4pf5nsw2 300 19 DNA dna NN cord-261417-4pf5nsw2 300 20 melting melting NN cord-261417-4pf5nsw2 300 21 on on IN cord-261417-4pf5nsw2 300 22 yeast yeast NN cord-261417-4pf5nsw2 300 23 RNA RNA NNP cord-261417-4pf5nsw2 300 24 polymerase polymerase NN cord-261417-4pf5nsw2 300 25 II II NNP cord-261417-4pf5nsw2 300 26 promoters promoter NNS cord-261417-4pf5nsw2 301 1 Transcription transcription NN cord-261417-4pf5nsw2 301 2 initiation initiation NN cord-261417-4pf5nsw2 301 3 complex complex JJ cord-261417-4pf5nsw2 301 4 structures structure NNS cord-261417-4pf5nsw2 301 5 elucidate elucidate VBP cord-261417-4pf5nsw2 301 6 DNA DNA NNP cord-261417-4pf5nsw2 301 7 opening opening NN cord-261417-4pf5nsw2 301 8 Control Control NNP cord-261417-4pf5nsw2 301 9 of of IN cord-261417-4pf5nsw2 301 10 transcriptional transcriptional JJ cord-261417-4pf5nsw2 301 11 elongation elongation NN cord-261417-4pf5nsw2 301 12 Global global JJ cord-261417-4pf5nsw2 301 13 burden burden NN cord-261417-4pf5nsw2 301 14 of of IN cord-261417-4pf5nsw2 301 15 acute acute JJ cord-261417-4pf5nsw2 301 16 lower low JJR cord-261417-4pf5nsw2 301 17 respiratory respiratory JJ cord-261417-4pf5nsw2 301 18 infections infection NNS cord-261417-4pf5nsw2 301 19 due due JJ cord-261417-4pf5nsw2 301 20 to to IN cord-261417-4pf5nsw2 301 21 respiratory respiratory JJ cord-261417-4pf5nsw2 301 22 syncytial syncytial JJ cord-261417-4pf5nsw2 301 23 virus virus NN cord-261417-4pf5nsw2 301 24 in in IN cord-261417-4pf5nsw2 301 25 young young JJ cord-261417-4pf5nsw2 301 26 children child NNS cord-261417-4pf5nsw2 301 27 : : : cord-261417-4pf5nsw2 301 28 A a DT cord-261417-4pf5nsw2 301 29 systematic systematic JJ cord-261417-4pf5nsw2 301 30 review review NN cord-261417-4pf5nsw2 301 31 and and CC cord-261417-4pf5nsw2 301 32 meta meta NNP cord-261417-4pf5nsw2 301 33 - - HYPH cord-261417-4pf5nsw2 301 34 analysis analysis NN cord-261417-4pf5nsw2 301 35 Respiratory respiratory JJ cord-261417-4pf5nsw2 301 36 syncytial syncytial JJ cord-261417-4pf5nsw2 301 37 virus virus NN cord-261417-4pf5nsw2 301 38 polymerase polymerase NN cord-261417-4pf5nsw2 301 39 can can MD cord-261417-4pf5nsw2 301 40 initiate initiate VB cord-261417-4pf5nsw2 301 41 transcription transcription NN cord-261417-4pf5nsw2 301 42 from from IN cord-261417-4pf5nsw2 301 43 position position NN cord-261417-4pf5nsw2 301 44 3 3 CD cord-261417-4pf5nsw2 301 45 of of IN cord-261417-4pf5nsw2 301 46 the the DT cord-261417-4pf5nsw2 301 47 leader leader NN cord-261417-4pf5nsw2 301 48 promoter promoter NN cord-261417-4pf5nsw2 301 49 Transcriptional Transcriptional NNP cord-261417-4pf5nsw2 301 50 activities activity NNS cord-261417-4pf5nsw2 301 51 of of IN cord-261417-4pf5nsw2 301 52 reovirus reovirus NNP cord-261417-4pf5nsw2 301 53 RNA RNA NNP cord-261417-4pf5nsw2 301 54 polymerase polymerase NN cord-261417-4pf5nsw2 301 55 in in IN cord-261417-4pf5nsw2 301 56 recoated recoate VBN cord-261417-4pf5nsw2 301 57 cores core NNS cord-261417-4pf5nsw2 301 58 . . . cord-261417-4pf5nsw2 302 1 Initiation initiation NN cord-261417-4pf5nsw2 302 2 and and CC cord-261417-4pf5nsw2 302 3 elongation elongation NN cord-261417-4pf5nsw2 302 4 are be VBP cord-261417-4pf5nsw2 302 5 regulated regulate VBN cord-261417-4pf5nsw2 302 6 by by IN cord-261417-4pf5nsw2 302 7 separate separate JJ cord-261417-4pf5nsw2 302 8 mechanisms mechanism NNS cord-261417-4pf5nsw2 302 9 Mechanism Mechanism NNP cord-261417-4pf5nsw2 302 10 of of IN cord-261417-4pf5nsw2 302 11 RNA RNA NNP cord-261417-4pf5nsw2 302 12 synthesis synthesis NN cord-261417-4pf5nsw2 302 13 initiation initiation NN cord-261417-4pf5nsw2 302 14 by by IN cord-261417-4pf5nsw2 302 15 the the DT cord-261417-4pf5nsw2 302 16 vesicular vesicular JJ cord-261417-4pf5nsw2 302 17 stomatitis stomatitis NN cord-261417-4pf5nsw2 302 18 virus virus NN cord-261417-4pf5nsw2 302 19 polymerase polymerase NN cord-261417-4pf5nsw2 302 20 Template template NN cord-261417-4pf5nsw2 302 21 / / SYM cord-261417-4pf5nsw2 302 22 primer primer NN cord-261417-4pf5nsw2 302 23 requirements requirement NNS cord-261417-4pf5nsw2 302 24 and and CC cord-261417-4pf5nsw2 302 25 single single JJ cord-261417-4pf5nsw2 302 26 nucleotide nucleotide JJ cord-261417-4pf5nsw2 302 27 incorporation incorporation NN cord-261417-4pf5nsw2 302 28 by by IN cord-261417-4pf5nsw2 303 1 hepatitis hepatitis NNP cord-261417-4pf5nsw2 303 2 C C NNP cord-261417-4pf5nsw2 303 3 virus virus NN cord-261417-4pf5nsw2 303 4 nonstructural nonstructural JJ cord-261417-4pf5nsw2 303 5 protein protein NN cord-261417-4pf5nsw2 303 6 5B 5b NN cord-261417-4pf5nsw2 303 7 polymerase polymerase NN cord-261417-4pf5nsw2 303 8 Initiation initiation NN cord-261417-4pf5nsw2 303 9 and and CC cord-261417-4pf5nsw2 303 10 regulation regulation NN cord-261417-4pf5nsw2 303 11 of of IN cord-261417-4pf5nsw2 303 12 paramyxovirus paramyxovirus JJ cord-261417-4pf5nsw2 303 13 transcription transcription NN cord-261417-4pf5nsw2 303 14 and and CC cord-261417-4pf5nsw2 303 15 replication replication NN cord-261417-4pf5nsw2 303 16 Analysis Analysis NNP cord-261417-4pf5nsw2 303 17 of of IN cord-261417-4pf5nsw2 303 18 the the DT cord-261417-4pf5nsw2 303 19 gene gene NN cord-261417-4pf5nsw2 303 20 start start NN cord-261417-4pf5nsw2 303 21 and and CC cord-261417-4pf5nsw2 303 22 gene gene NN cord-261417-4pf5nsw2 303 23 end end NN cord-261417-4pf5nsw2 303 24 signals signal NNS cord-261417-4pf5nsw2 303 25 of of IN cord-261417-4pf5nsw2 303 26 human human JJ cord-261417-4pf5nsw2 303 27 respiratory respiratory JJ cord-261417-4pf5nsw2 303 28 syncytial syncytial JJ cord-261417-4pf5nsw2 303 29 virus virus NN cord-261417-4pf5nsw2 303 30 : : : cord-261417-4pf5nsw2 303 31 Quasi quasi JJ cord-261417-4pf5nsw2 303 32 - - JJ cord-261417-4pf5nsw2 303 33 templated templated JJ cord-261417-4pf5nsw2 303 34 initiation initiation NN cord-261417-4pf5nsw2 303 35 at at IN cord-261417-4pf5nsw2 303 36 position position NN cord-261417-4pf5nsw2 303 37 1 1 CD cord-261417-4pf5nsw2 303 38 of of IN cord-261417-4pf5nsw2 303 39 the the DT cord-261417-4pf5nsw2 303 40 encoded encode VBN cord-261417-4pf5nsw2 303 41 mRNA mrna NN cord-261417-4pf5nsw2 303 42 Molecular molecular JJ cord-261417-4pf5nsw2 303 43 basis basis NN cord-261417-4pf5nsw2 303 44 for for IN cord-261417-4pf5nsw2 303 45 nucleotide nucleotide JJ cord-261417-4pf5nsw2 303 46 conservation conservation NN cord-261417-4pf5nsw2 303 47 at at IN cord-261417-4pf5nsw2 303 48 the the DT cord-261417-4pf5nsw2 303 49 ends end NNS cord-261417-4pf5nsw2 303 50 of of IN cord-261417-4pf5nsw2 303 51 the the DT cord-261417-4pf5nsw2 303 52 dengue dengue NN cord-261417-4pf5nsw2 303 53 virus virus NN cord-261417-4pf5nsw2 303 54 genome genome NN cord-261417-4pf5nsw2 303 55 Crystal Crystal NNP cord-261417-4pf5nsw2 303 56 structure structure NN cord-261417-4pf5nsw2 303 57 of of IN cord-261417-4pf5nsw2 303 58 the the DT cord-261417-4pf5nsw2 303 59 dengue dengue NN cord-261417-4pf5nsw2 303 60 virus virus NN cord-261417-4pf5nsw2 303 61 RNA rna NN cord-261417-4pf5nsw2 303 62 - - HYPH cord-261417-4pf5nsw2 303 63 dependent dependent JJ cord-261417-4pf5nsw2 303 64 RNA RNA NNP cord-261417-4pf5nsw2 303 65 polymerase polymerase NN cord-261417-4pf5nsw2 303 66 catalytic catalytic JJ cord-261417-4pf5nsw2 303 67 domain domain NN cord-261417-4pf5nsw2 303 68 at at IN cord-261417-4pf5nsw2 303 69 1.85-angstrom 1.85-angstrom CD cord-261417-4pf5nsw2 303 70 resolution resolution NN cord-261417-4pf5nsw2 304 1 The the DT cord-261417-4pf5nsw2 304 2 respiratory respiratory JJ cord-261417-4pf5nsw2 304 3 syncytial syncytial JJ cord-261417-4pf5nsw2 304 4 virus virus NN cord-261417-4pf5nsw2 304 5 polymerase polymerase NN cord-261417-4pf5nsw2 304 6 has have VBZ cord-261417-4pf5nsw2 304 7 multiple multiple JJ cord-261417-4pf5nsw2 304 8 RNA RNA NNP cord-261417-4pf5nsw2 304 9 synthesis synthesis NN cord-261417-4pf5nsw2 304 10 activities activity NNS cord-261417-4pf5nsw2 304 11 at at IN cord-261417-4pf5nsw2 304 12 the the DT cord-261417-4pf5nsw2 304 13 promoter promoter NN cord-261417-4pf5nsw2 304 14 Transcription transcription NN cord-261417-4pf5nsw2 304 15 and and CC cord-261417-4pf5nsw2 304 16 replication replication NN cord-261417-4pf5nsw2 304 17 of of IN cord-261417-4pf5nsw2 304 18 nonsegmented nonsegmente VBN cord-261417-4pf5nsw2 304 19 negative negative JJ cord-261417-4pf5nsw2 304 20 - - HYPH cord-261417-4pf5nsw2 304 21 strand strand NN cord-261417-4pf5nsw2 304 22 RNA RNA NNP cord-261417-4pf5nsw2 304 23 viruses virus NNS cord-261417-4pf5nsw2 304 24 Regulation Regulation NNP cord-261417-4pf5nsw2 304 25 of of IN cord-261417-4pf5nsw2 304 26 flavivirus flavivirus NNP cord-261417-4pf5nsw2 304 27 RNA RNA NNP cord-261417-4pf5nsw2 304 28 synthesis synthesis NN cord-261417-4pf5nsw2 304 29 and and CC cord-261417-4pf5nsw2 304 30 capping cap VBG cord-261417-4pf5nsw2 304 31 Conventional conventional JJ cord-261417-4pf5nsw2 304 32 and and CC cord-261417-4pf5nsw2 304 33 unconventional unconventional JJ cord-261417-4pf5nsw2 304 34 mechanisms mechanism NNS cord-261417-4pf5nsw2 304 35 for for IN cord-261417-4pf5nsw2 304 36 capping cap VBG cord-261417-4pf5nsw2 304 37 viral viral JJ cord-261417-4pf5nsw2 304 38 mRNA mRNA NNP cord-261417-4pf5nsw2 304 39 Expression expression NN cord-261417-4pf5nsw2 304 40 , , , cord-261417-4pf5nsw2 304 41 purification purification NN cord-261417-4pf5nsw2 304 42 , , , cord-261417-4pf5nsw2 304 43 and and CC cord-261417-4pf5nsw2 304 44 characterization characterization NN cord-261417-4pf5nsw2 304 45 of of IN cord-261417-4pf5nsw2 304 46 the the DT cord-261417-4pf5nsw2 304 47 RNA RNA NNP cord-261417-4pf5nsw2 304 48 5 5 CD cord-261417-4pf5nsw2 304 49 -triphosphatase -triphosphatase NN cord-261417-4pf5nsw2 304 50 activity activity NN cord-261417-4pf5nsw2 304 51 of of IN cord-261417-4pf5nsw2 304 52 dengue dengue NN cord-261417-4pf5nsw2 304 53 virus virus NN cord-261417-4pf5nsw2 304 54 type type NN cord-261417-4pf5nsw2 304 55 2 2 CD cord-261417-4pf5nsw2 304 56 nonstructural nonstructural JJ cord-261417-4pf5nsw2 304 57 protein protein NN cord-261417-4pf5nsw2 304 58 3 3 CD cord-261417-4pf5nsw2 305 1 The the DT cord-261417-4pf5nsw2 305 2 flavivirus flavivirus JJ cord-261417-4pf5nsw2 305 3 NS5 ns5 JJ cord-261417-4pf5nsw2 305 4 protein protein NN cord-261417-4pf5nsw2 305 5 is be VBZ cord-261417-4pf5nsw2 305 6 a a DT cord-261417-4pf5nsw2 305 7 true true JJ cord-261417-4pf5nsw2 305 8 RNA rna NN cord-261417-4pf5nsw2 305 9 guanylyltransferase guanylyltransferase NN cord-261417-4pf5nsw2 305 10 that that WDT cord-261417-4pf5nsw2 305 11 catalyzes catalyze VBZ cord-261417-4pf5nsw2 305 12 a a DT cord-261417-4pf5nsw2 305 13 two two CD cord-261417-4pf5nsw2 305 14 - - HYPH cord-261417-4pf5nsw2 305 15 step step NN cord-261417-4pf5nsw2 305 16 reaction reaction NN cord-261417-4pf5nsw2 305 17 to to TO cord-261417-4pf5nsw2 305 18 form form VB cord-261417-4pf5nsw2 305 19 the the DT cord-261417-4pf5nsw2 305 20 RNA RNA NNP cord-261417-4pf5nsw2 305 21 cap cap NN cord-261417-4pf5nsw2 305 22 structure structure NN cord-261417-4pf5nsw2 306 1 Nile Nile NNP cord-261417-4pf5nsw2 306 2 virus virus NN cord-261417-4pf5nsw2 306 3 5 5 CD cord-261417-4pf5nsw2 306 4 -cap -cap : cord-261417-4pf5nsw2 306 5 structure structure NN cord-261417-4pf5nsw2 306 6 is be VBZ cord-261417-4pf5nsw2 306 7 formed form VBN cord-261417-4pf5nsw2 306 8 by by IN cord-261417-4pf5nsw2 306 9 sequential sequential JJ cord-261417-4pf5nsw2 306 10 guanine guanine NN cord-261417-4pf5nsw2 306 11 N-7 N-7 NNP cord-261417-4pf5nsw2 306 12 and and CC cord-261417-4pf5nsw2 306 13 ribose ribose NN cord-261417-4pf5nsw2 306 14 2 2 CD cord-261417-4pf5nsw2 306 15 -O -O HYPH cord-261417-4pf5nsw2 306 16 methylations methylation NNS cord-261417-4pf5nsw2 306 17 by by IN cord-261417-4pf5nsw2 306 18 nonstructural nonstructural JJ cord-261417-4pf5nsw2 306 19 protein protein NN cord-261417-4pf5nsw2 306 20 5 5 CD cord-261417-4pf5nsw2 306 21 Regulation Regulation NNP cord-261417-4pf5nsw2 306 22 of of IN cord-261417-4pf5nsw2 306 23 flavivirus flavivirus NNP cord-261417-4pf5nsw2 306 24 RNA RNA NNP cord-261417-4pf5nsw2 306 25 synthesis synthesis NN cord-261417-4pf5nsw2 306 26 and and CC cord-261417-4pf5nsw2 306 27 replication replication NN cord-261417-4pf5nsw2 306 28 Sequence sequence NN cord-261417-4pf5nsw2 306 29 comparison comparison NN cord-261417-4pf5nsw2 306 30 of of IN cord-261417-4pf5nsw2 306 31 five five CD cord-261417-4pf5nsw2 306 32 polymerases polymerase NNS cord-261417-4pf5nsw2 306 33 ( ( -LRB- cord-261417-4pf5nsw2 306 34 l l NN cord-261417-4pf5nsw2 306 35 proteins protein NNS cord-261417-4pf5nsw2 306 36 ) ) -RRB- cord-261417-4pf5nsw2 306 37 of of IN cord-261417-4pf5nsw2 306 38 unsegmented unsegmented JJ cord-261417-4pf5nsw2 306 39 negative negative JJ cord-261417-4pf5nsw2 306 40 - - HYPH cord-261417-4pf5nsw2 306 41 strand strand NN cord-261417-4pf5nsw2 306 42 RNA RNA NNP cord-261417-4pf5nsw2 306 43 viruses virus NNS cord-261417-4pf5nsw2 306 44 : : : cord-261417-4pf5nsw2 306 45 Theoretical theoretical JJ cord-261417-4pf5nsw2 306 46 assignment assignment NN cord-261417-4pf5nsw2 306 47 of of IN cord-261417-4pf5nsw2 306 48 functional functional JJ cord-261417-4pf5nsw2 306 49 domains domain NNS cord-261417-4pf5nsw2 306 50 Structure structure NN cord-261417-4pf5nsw2 306 51 and and CC cord-261417-4pf5nsw2 306 52 functional functional JJ cord-261417-4pf5nsw2 306 53 analysis analysis NN cord-261417-4pf5nsw2 306 54 of of IN cord-261417-4pf5nsw2 306 55 the the DT cord-261417-4pf5nsw2 306 56 RNA RNA NNP cord-261417-4pf5nsw2 306 57 - - , cord-261417-4pf5nsw2 306 58 and and CC cord-261417-4pf5nsw2 306 59 viral viral JJ cord-261417-4pf5nsw2 306 60 phosphoprotein phosphoprotein NN cord-261417-4pf5nsw2 306 61 - - HYPH cord-261417-4pf5nsw2 306 62 binding bind VBG cord-261417-4pf5nsw2 306 63 domain domain NN cord-261417-4pf5nsw2 306 64 of of IN cord-261417-4pf5nsw2 306 65 respiratory respiratory JJ cord-261417-4pf5nsw2 306 66 syncytial syncytial JJ cord-261417-4pf5nsw2 306 67 virus virus NN cord-261417-4pf5nsw2 306 68 M2 M2 NNP cord-261417-4pf5nsw2 306 69 - - SYM cord-261417-4pf5nsw2 306 70 1 1 CD cord-261417-4pf5nsw2 306 71 protein protein NN cord-261417-4pf5nsw2 307 1 The the DT cord-261417-4pf5nsw2 307 2 respiratory respiratory JJ cord-261417-4pf5nsw2 307 3 syncytial syncytial JJ cord-261417-4pf5nsw2 307 4 virus virus NN cord-261417-4pf5nsw2 307 5 M2 M2 NNP cord-261417-4pf5nsw2 307 6 - - SYM cord-261417-4pf5nsw2 307 7 1 1 CD cord-261417-4pf5nsw2 307 8 protein protein NN cord-261417-4pf5nsw2 307 9 forms form NNS cord-261417-4pf5nsw2 307 10 tetramers tetramer NNS cord-261417-4pf5nsw2 307 11 and and CC cord-261417-4pf5nsw2 307 12 interacts interact VBZ cord-261417-4pf5nsw2 307 13 with with IN cord-261417-4pf5nsw2 307 14 RNA RNA NNP cord-261417-4pf5nsw2 307 15 and and CC cord-261417-4pf5nsw2 307 16 p p NN cord-261417-4pf5nsw2 307 17 in in IN cord-261417-4pf5nsw2 307 18 a a DT cord-261417-4pf5nsw2 307 19 competitive competitive JJ cord-261417-4pf5nsw2 307 20 manner manner NN cord-261417-4pf5nsw2 307 21 Crystal Crystal NNP cord-261417-4pf5nsw2 307 22 structure structure NN cord-261417-4pf5nsw2 307 23 of of IN cord-261417-4pf5nsw2 307 24 a a DT cord-261417-4pf5nsw2 307 25 nucleocapsid nucleocapsid NN cord-261417-4pf5nsw2 307 26 - - HYPH cord-261417-4pf5nsw2 307 27 like like JJ cord-261417-4pf5nsw2 307 28 nucleoprotein nucleoprotein NNP cord-261417-4pf5nsw2 307 29 - - HYPH cord-261417-4pf5nsw2 307 30 RNA RNA NNP cord-261417-4pf5nsw2 307 31 complex complex NN cord-261417-4pf5nsw2 307 32 of of IN cord-261417-4pf5nsw2 307 33 respiratory respiratory JJ cord-261417-4pf5nsw2 307 34 syncytial syncytial JJ cord-261417-4pf5nsw2 307 35 virus virus NN cord-261417-4pf5nsw2 307 36 Unconventional unconventional JJ cord-261417-4pf5nsw2 307 37 mechanism mechanism NN cord-261417-4pf5nsw2 307 38 of of IN cord-261417-4pf5nsw2 307 39 mRNA mrna NN cord-261417-4pf5nsw2 307 40 capping cap VBG cord-261417-4pf5nsw2 307 41 by by IN cord-261417-4pf5nsw2 307 42 the the DT cord-261417-4pf5nsw2 307 43 RNA RNA NNP cord-261417-4pf5nsw2 307 44 - - HYPH cord-261417-4pf5nsw2 307 45 dependent dependent JJ cord-261417-4pf5nsw2 307 46 RNA RNA NNP cord-261417-4pf5nsw2 307 47 polymerase polymerase NN cord-261417-4pf5nsw2 307 48 of of IN cord-261417-4pf5nsw2 307 49 vesicular vesicular JJ cord-261417-4pf5nsw2 307 50 stomatitis stomatitis NN cord-261417-4pf5nsw2 307 51 virus virus NN cord-261417-4pf5nsw2 307 52 Influenza Influenza NNP cord-261417-4pf5nsw2 307 53 virus virus NN cord-261417-4pf5nsw2 307 54 RNA rna NN cord-261417-4pf5nsw2 307 55 polymerase polymerase NN cord-261417-4pf5nsw2 307 56 : : : cord-261417-4pf5nsw2 308 1 Insights insight NNS cord-261417-4pf5nsw2 308 2 into into IN cord-261417-4pf5nsw2 308 3 the the DT cord-261417-4pf5nsw2 308 4 mechanisms mechanism NNS cord-261417-4pf5nsw2 308 5 of of IN cord-261417-4pf5nsw2 308 6 viral viral JJ cord-261417-4pf5nsw2 308 7 RNA RNA NNP cord-261417-4pf5nsw2 308 8 synthesis synthesis NN cord-261417-4pf5nsw2 308 9 Structural structural JJ cord-261417-4pf5nsw2 308 10 insight insight NN cord-261417-4pf5nsw2 308 11 into into IN cord-261417-4pf5nsw2 308 12 cap cap NN cord-261417-4pf5nsw2 308 13 - - HYPH cord-261417-4pf5nsw2 308 14 snatching snatching NN cord-261417-4pf5nsw2 308 15 and and CC cord-261417-4pf5nsw2 308 16 RNA RNA NNP cord-261417-4pf5nsw2 308 17 synthesis synthesis NN cord-261417-4pf5nsw2 308 18 by by IN cord-261417-4pf5nsw2 308 19 influenza influenza NN cord-261417-4pf5nsw2 308 20 polymerase polymerase NNP cord-261417-4pf5nsw2 308 21 Structure Structure NNP cord-261417-4pf5nsw2 308 22 of of IN cord-261417-4pf5nsw2 308 23 influenza influenza NN cord-261417-4pf5nsw2 308 24 a a DT cord-261417-4pf5nsw2 308 25 polymerase polymerase NN cord-261417-4pf5nsw2 308 26 bound bind VBN cord-261417-4pf5nsw2 308 27 to to IN cord-261417-4pf5nsw2 308 28 the the DT cord-261417-4pf5nsw2 308 29 viral viral JJ cord-261417-4pf5nsw2 308 30 RNA RNA NNP cord-261417-4pf5nsw2 308 31 promoter promoter NN cord-261417-4pf5nsw2 308 32 Crystal Crystal NNP cord-261417-4pf5nsw2 308 33 structure structure NN cord-261417-4pf5nsw2 308 34 of of IN cord-261417-4pf5nsw2 308 35 the the DT cord-261417-4pf5nsw2 308 36 RNA RNA NNP cord-261417-4pf5nsw2 308 37 - - HYPH cord-261417-4pf5nsw2 308 38 dependent dependent JJ cord-261417-4pf5nsw2 308 39 RNA RNA NNP cord-261417-4pf5nsw2 308 40 polymerase polymerase NN cord-261417-4pf5nsw2 308 41 from from IN cord-261417-4pf5nsw2 308 42 influenza influenza NN cord-261417-4pf5nsw2 308 43 C C NNP cord-261417-4pf5nsw2 308 44 virus virus NN cord-261417-4pf5nsw2 308 45 Single single JJ cord-261417-4pf5nsw2 308 46 - - HYPH cord-261417-4pf5nsw2 308 47 molecule molecule NN cord-261417-4pf5nsw2 308 48 FRET fret NN cord-261417-4pf5nsw2 308 49 reveals reveal VBZ cord-261417-4pf5nsw2 308 50 the the DT cord-261417-4pf5nsw2 308 51 pre pre NN cord-261417-4pf5nsw2 308 52 - - NN cord-261417-4pf5nsw2 308 53 initiation initiation NN cord-261417-4pf5nsw2 308 54 and and CC cord-261417-4pf5nsw2 308 55 initiation initiation NN cord-261417-4pf5nsw2 308 56 conformations conformation NNS cord-261417-4pf5nsw2 308 57 of of IN cord-261417-4pf5nsw2 308 58 influenza influenza NN cord-261417-4pf5nsw2 308 59 virus virus NN cord-261417-4pf5nsw2 308 60 promoter promoter NN cord-261417-4pf5nsw2 308 61 RNA RNA NNP cord-261417-4pf5nsw2 308 62 An An NNP cord-261417-4pf5nsw2 308 63 in in FW cord-261417-4pf5nsw2 308 64 vitro vitro FW cord-261417-4pf5nsw2 308 65 fluorescence fluorescence NN cord-261417-4pf5nsw2 308 66 based base VBN cord-261417-4pf5nsw2 308 67 study study NN cord-261417-4pf5nsw2 308 68 of of IN cord-261417-4pf5nsw2 308 69 initiation initiation NN cord-261417-4pf5nsw2 308 70 of of IN cord-261417-4pf5nsw2 308 71 RNA RNA NNP cord-261417-4pf5nsw2 308 72 synthesis synthesis NN cord-261417-4pf5nsw2 308 73 by by IN cord-261417-4pf5nsw2 308 74 influenza influenza NN cord-261417-4pf5nsw2 308 75 B b NN cord-261417-4pf5nsw2 308 76 polymerase polymerase NN cord-261417-4pf5nsw2 309 1 RNA RNA NNP cord-261417-4pf5nsw2 309 2 - - HYPH cord-261417-4pf5nsw2 309 3 free free JJ cord-261417-4pf5nsw2 309 4 and and CC cord-261417-4pf5nsw2 309 5 ribonucleoprotein ribonucleoprotein NN cord-261417-4pf5nsw2 309 6 - - HYPH cord-261417-4pf5nsw2 309 7 associated associate VBN cord-261417-4pf5nsw2 309 8 influenza influenza NN cord-261417-4pf5nsw2 309 9 virus virus NN cord-261417-4pf5nsw2 309 10 polymerases polymerase NNS cord-261417-4pf5nsw2 309 11 directly directly RB cord-261417-4pf5nsw2 309 12 bind bind VBP cord-261417-4pf5nsw2 309 13 the the DT cord-261417-4pf5nsw2 309 14 serine-5-phosphorylated serine-5-phosphorylated NNP cord-261417-4pf5nsw2 309 15 carboxyl carboxyl NN cord-261417-4pf5nsw2 309 16 - - HYPH cord-261417-4pf5nsw2 309 17 terminal terminal NN cord-261417-4pf5nsw2 309 18 domain domain NN cord-261417-4pf5nsw2 309 19 of of IN cord-261417-4pf5nsw2 309 20 host host NN cord-261417-4pf5nsw2 309 21 RNA RNA NNP cord-261417-4pf5nsw2 309 22 polymerase polymerase NN cord-261417-4pf5nsw2 309 23 II II NNP cord-261417-4pf5nsw2 309 24 Influenza Influenza NNP cord-261417-4pf5nsw2 309 25 A a DT cord-261417-4pf5nsw2 309 26 virus virus NN cord-261417-4pf5nsw2 309 27 preferentially preferentially RB cord-261417-4pf5nsw2 309 28 snatches snatch VBZ cord-261417-4pf5nsw2 309 29 noncoding noncoding JJ cord-261417-4pf5nsw2 309 30 RNA RNA NNP cord-261417-4pf5nsw2 309 31 caps cap NNS cord-261417-4pf5nsw2 309 32 Sequencing Sequencing NNP cord-261417-4pf5nsw2 310 1 the the DT cord-261417-4pf5nsw2 310 2 cap cap NN cord-261417-4pf5nsw2 310 3 - - HYPH cord-261417-4pf5nsw2 310 4 snatching snatch VBG cord-261417-4pf5nsw2 310 5 repertoire repertoire NN cord-261417-4pf5nsw2 310 6 of of IN cord-261417-4pf5nsw2 310 7 H1N1 H1N1 NNP cord-261417-4pf5nsw2 310 8 influenza influenza NN cord-261417-4pf5nsw2 310 9 provides provide VBZ cord-261417-4pf5nsw2 310 10 insight insight NN cord-261417-4pf5nsw2 310 11 into into IN cord-261417-4pf5nsw2 310 12 the the DT cord-261417-4pf5nsw2 310 13 mechanism mechanism NN cord-261417-4pf5nsw2 310 14 of of IN cord-261417-4pf5nsw2 310 15 viral viral JJ cord-261417-4pf5nsw2 310 16 transcription transcription NN cord-261417-4pf5nsw2 310 17 initiation initiation NN cord-261417-4pf5nsw2 310 18 Deep deep JJ cord-261417-4pf5nsw2 310 19 sequencing sequencing NN cord-261417-4pf5nsw2 311 1 reveals reveal VBZ cord-261417-4pf5nsw2 311 2 the the DT cord-261417-4pf5nsw2 311 3 eight eight CD cord-261417-4pf5nsw2 311 4 facets facet NNS cord-261417-4pf5nsw2 311 5 of of IN cord-261417-4pf5nsw2 311 6 the the DT cord-261417-4pf5nsw2 311 7 influenza influenza NN cord-261417-4pf5nsw2 311 8 A a NN cord-261417-4pf5nsw2 311 9 / / SYM cord-261417-4pf5nsw2 311 10 HongKong/1/1968 HongKong/1/1968 NNP cord-261417-4pf5nsw2 311 11 ( ( -LRB- cord-261417-4pf5nsw2 311 12 H3N2 H3N2 NNP cord-261417-4pf5nsw2 311 13 ) ) -RRB- cord-261417-4pf5nsw2 311 14 virus virus NN cord-261417-4pf5nsw2 311 15 cap cap NN cord-261417-4pf5nsw2 311 16 - - HYPH cord-261417-4pf5nsw2 311 17 snatching snatching NN cord-261417-4pf5nsw2 311 18 process process NN cord-261417-4pf5nsw2 311 19 Polyadenylation Polyadenylation NNP cord-261417-4pf5nsw2 311 20 of of IN cord-261417-4pf5nsw2 311 21 influenza influenza NNP cord-261417-4pf5nsw2 311 22 virus virus NN cord-261417-4pf5nsw2 311 23 mRNA mRNA NNP cord-261417-4pf5nsw2 311 24 transcribed transcribe VBN cord-261417-4pf5nsw2 311 25 in in IN cord-261417-4pf5nsw2 311 26 vitro vitro FW cord-261417-4pf5nsw2 311 27 from from IN cord-261417-4pf5nsw2 311 28 model model NN cord-261417-4pf5nsw2 311 29 virion virion NN cord-261417-4pf5nsw2 311 30 RNA rna NN cord-261417-4pf5nsw2 311 31 templates template NNS cord-261417-4pf5nsw2 311 32 : : : cord-261417-4pf5nsw2 312 1 Requirement requirement NN cord-261417-4pf5nsw2 312 2 for for IN cord-261417-4pf5nsw2 312 3 5 5 CD cord-261417-4pf5nsw2 312 4 conserved conserved JJ cord-261417-4pf5nsw2 312 5 sequences sequence NNS cord-261417-4pf5nsw2 313 1 The the DT cord-261417-4pf5nsw2 313 2 influenza influenza NN cord-261417-4pf5nsw2 313 3 virus virus NN cord-261417-4pf5nsw2 313 4 NS1 ns1 NN cord-261417-4pf5nsw2 313 5 protein protein NN cord-261417-4pf5nsw2 313 6 binds bind VBZ cord-261417-4pf5nsw2 313 7 to to IN cord-261417-4pf5nsw2 313 8 a a DT cord-261417-4pf5nsw2 313 9 specific specific JJ cord-261417-4pf5nsw2 313 10 region region NN cord-261417-4pf5nsw2 313 11 in in IN cord-261417-4pf5nsw2 313 12 human human JJ cord-261417-4pf5nsw2 313 13 U6 U6 NNP cord-261417-4pf5nsw2 313 14 snRNA snrna NN cord-261417-4pf5nsw2 313 15 and and CC cord-261417-4pf5nsw2 313 16 inhibits inhibit VBZ cord-261417-4pf5nsw2 314 1 U6-U2 U6-U2 NNP cord-261417-4pf5nsw2 314 2 and and CC cord-261417-4pf5nsw2 314 3 U6-U4 U6-U4 NNP cord-261417-4pf5nsw2 314 4 snRNA snrna NN cord-261417-4pf5nsw2 314 5 interactions interaction NNS cord-261417-4pf5nsw2 314 6 during during IN cord-261417-4pf5nsw2 314 7 splicing splice VBG cord-261417-4pf5nsw2 314 8 Mammalian mammalian JJ cord-261417-4pf5nsw2 314 9 net net JJ cord-261417-4pf5nsw2 314 10 - - HYPH cord-261417-4pf5nsw2 314 11 seq seq NN cord-261417-4pf5nsw2 314 12 reveals reveal VBZ cord-261417-4pf5nsw2 314 13 genome genome NN cord-261417-4pf5nsw2 314 14 - - HYPH cord-261417-4pf5nsw2 314 15 wide wide JJ cord-261417-4pf5nsw2 314 16 nascent nascent JJ cord-261417-4pf5nsw2 314 17 transcription transcription NN cord-261417-4pf5nsw2 314 18 coupled couple VBN cord-261417-4pf5nsw2 314 19 to to IN cord-261417-4pf5nsw2 314 20 RNA RNA NNP cord-261417-4pf5nsw2 314 21 processing processing NN cord-261417-4pf5nsw2 314 22 Stable stable JJ cord-261417-4pf5nsw2 314 23 pausing pause VBG cord-261417-4pf5nsw2 314 24 by by IN cord-261417-4pf5nsw2 314 25 RNA RNA NNP cord-261417-4pf5nsw2 314 26 polymerase polymerase NN cord-261417-4pf5nsw2 314 27 II II NNP cord-261417-4pf5nsw2 314 28 provides provide VBZ cord-261417-4pf5nsw2 314 29 an an DT cord-261417-4pf5nsw2 314 30 opportunity opportunity NN cord-261417-4pf5nsw2 314 31 to to TO cord-261417-4pf5nsw2 314 32 target target VB cord-261417-4pf5nsw2 314 33 and and CC cord-261417-4pf5nsw2 314 34 integrate integrate VB cord-261417-4pf5nsw2 314 35 regulatory regulatory JJ cord-261417-4pf5nsw2 314 36 signals signal NNS cord-261417-4pf5nsw2 315 1 Promoter promoter NN cord-261417-4pf5nsw2 315 2 - - HYPH cord-261417-4pf5nsw2 315 3 proximal proximal JJ cord-261417-4pf5nsw2 315 4 pausing pausing NN cord-261417-4pf5nsw2 315 5 of of IN cord-261417-4pf5nsw2 315 6 RNA RNA NNP cord-261417-4pf5nsw2 315 7 polymerase polymerase NN cord-261417-4pf5nsw2 315 8 II II NNP cord-261417-4pf5nsw2 315 9 : : : cord-261417-4pf5nsw2 316 1 Emerging emerge VBG cord-261417-4pf5nsw2 316 2 roles role NNS cord-261417-4pf5nsw2 316 3 in in IN cord-261417-4pf5nsw2 316 4 metazoans metazoans NNP cord-261417-4pf5nsw2 316 5 SETX SETX NNP cord-261417-4pf5nsw2 316 6 , , , cord-261417-4pf5nsw2 316 7 XRN2 XRN2 NNP cord-261417-4pf5nsw2 316 8 , , , cord-261417-4pf5nsw2 316 9 and and CC cord-261417-4pf5nsw2 316 10 RRP6 RRP6 NNP cord-261417-4pf5nsw2 316 11 co co NN cord-261417-4pf5nsw2 316 12 - - VB cord-261417-4pf5nsw2 316 13 operate operate VB cord-261417-4pf5nsw2 316 14 to to TO cord-261417-4pf5nsw2 316 15 induce induce VB cord-261417-4pf5nsw2 316 16 premature premature JJ cord-261417-4pf5nsw2 316 17 termination termination NN cord-261417-4pf5nsw2 316 18 of of IN cord-261417-4pf5nsw2 316 19 transcription transcription NN cord-261417-4pf5nsw2 316 20 by by IN cord-261417-4pf5nsw2 316 21 RNAPII RNAPII NNP cord-261417-4pf5nsw2 316 22 7SK 7SK NNP cord-261417-4pf5nsw2 316 23 small small JJ cord-261417-4pf5nsw2 316 24 nuclear nuclear JJ cord-261417-4pf5nsw2 316 25 RNA RNA NNP cord-261417-4pf5nsw2 316 26 binds bind VBZ cord-261417-4pf5nsw2 316 27 to to IN cord-261417-4pf5nsw2 316 28 and and CC cord-261417-4pf5nsw2 316 29 inhibits inhibit VBZ cord-261417-4pf5nsw2 316 30 the the DT cord-261417-4pf5nsw2 316 31 activity activity NN cord-261417-4pf5nsw2 316 32 of of IN cord-261417-4pf5nsw2 316 33 CDK9 CDK9 NNP cord-261417-4pf5nsw2 316 34 / / SYM cord-261417-4pf5nsw2 316 35 Cyclin Cyclin NNP cord-261417-4pf5nsw2 316 36 T T NNP cord-261417-4pf5nsw2 316 37 complexes complex NNS cord-261417-4pf5nsw2 317 1 Long Long NNP cord-261417-4pf5nsw2 317 2 noncoding noncoding NNP cord-261417-4pf5nsw2 317 3 RNA RNA NNP cord-261417-4pf5nsw2 317 4 as as IN cord-261417-4pf5nsw2 317 5 modular modular JJ cord-261417-4pf5nsw2 317 6 scaffold scaffold NN cord-261417-4pf5nsw2 317 7 of of IN cord-261417-4pf5nsw2 317 8 histone histone NN cord-261417-4pf5nsw2 317 9 modification modification NN cord-261417-4pf5nsw2 317 10 complexes complex NNS cord-261417-4pf5nsw2 318 1 The the DT cord-261417-4pf5nsw2 318 2 7SK 7sk CD cord-261417-4pf5nsw2 318 3 small small JJ cord-261417-4pf5nsw2 318 4 nuclear nuclear JJ cord-261417-4pf5nsw2 318 5 RNA RNA NNP cord-261417-4pf5nsw2 318 6 inhibits inhibit VBZ cord-261417-4pf5nsw2 318 7 the the DT cord-261417-4pf5nsw2 318 8 CDK9 CDK9 NNP cord-261417-4pf5nsw2 318 9 / / SYM cord-261417-4pf5nsw2 318 10 Cyclin Cyclin NNP cord-261417-4pf5nsw2 318 11 T1 T1 NNP cord-261417-4pf5nsw2 318 12 kinase kinase NN cord-261417-4pf5nsw2 318 13 to to TO cord-261417-4pf5nsw2 318 14 control control VB cord-261417-4pf5nsw2 318 15 transcription transcription NN cord-261417-4pf5nsw2 318 16 Polycomb Polycomb NNP cord-261417-4pf5nsw2 318 17 proteins protein NNS cord-261417-4pf5nsw2 318 18 targeted target VBN cord-261417-4pf5nsw2 318 19 by by IN cord-261417-4pf5nsw2 318 20 a a DT cord-261417-4pf5nsw2 318 21 short short JJ cord-261417-4pf5nsw2 318 22 repeat repeat NN cord-261417-4pf5nsw2 318 23 RNA RNA NNP cord-261417-4pf5nsw2 318 24 to to IN cord-261417-4pf5nsw2 318 25 the the DT cord-261417-4pf5nsw2 318 26 mouse mouse NN cord-261417-4pf5nsw2 318 27 x x NN cord-261417-4pf5nsw2 318 28 chromosome chromosome NN cord-261417-4pf5nsw2 319 1 EBV EBV NNP cord-261417-4pf5nsw2 319 2 noncoding noncoding NNP cord-261417-4pf5nsw2 319 3 RNA RNA NNP cord-261417-4pf5nsw2 319 4 binds bind VBZ cord-261417-4pf5nsw2 319 5 nascent nascent JJ cord-261417-4pf5nsw2 319 6 RNA RNA NNP cord-261417-4pf5nsw2 319 7 to to TO cord-261417-4pf5nsw2 319 8 drive drive VB cord-261417-4pf5nsw2 319 9 host host NN cord-261417-4pf5nsw2 319 10 PAX5 PAX5 NNP cord-261417-4pf5nsw2 319 11 to to IN cord-261417-4pf5nsw2 319 12 viral viral JJ cord-261417-4pf5nsw2 319 13 DNA dna NN cord-261417-4pf5nsw2 320 1 Tat Tat NNP cord-261417-4pf5nsw2 320 2 trans trans NNP cord-261417-4pf5nsw2 320 3 - - VBZ cord-261417-4pf5nsw2 320 4 activates activate VBZ cord-261417-4pf5nsw2 320 5 the the DT cord-261417-4pf5nsw2 320 6 human human JJ cord-261417-4pf5nsw2 320 7 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 320 8 virus virus NN cord-261417-4pf5nsw2 320 9 through through IN cord-261417-4pf5nsw2 320 10 a a DT cord-261417-4pf5nsw2 320 11 nascent nascent JJ cord-261417-4pf5nsw2 320 12 RNA RNA NNP cord-261417-4pf5nsw2 320 13 target target NN cord-261417-4pf5nsw2 321 1 An an DT cord-261417-4pf5nsw2 321 2 inducible inducible JJ cord-261417-4pf5nsw2 321 3 transcription transcription NN cord-261417-4pf5nsw2 321 4 factor factor NN cord-261417-4pf5nsw2 321 5 activates activate VBZ cord-261417-4pf5nsw2 321 6 expression expression NN cord-261417-4pf5nsw2 321 7 of of IN cord-261417-4pf5nsw2 321 8 human human JJ cord-261417-4pf5nsw2 321 9 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 321 10 virus virus NN cord-261417-4pf5nsw2 321 11 in in IN cord-261417-4pf5nsw2 321 12 T T NNP cord-261417-4pf5nsw2 321 13 cells cell NNS cord-261417-4pf5nsw2 322 1 Specific specific JJ cord-261417-4pf5nsw2 322 2 NF nf NN cord-261417-4pf5nsw2 322 3 - - HYPH cord-261417-4pf5nsw2 322 4 κB κB NNP cord-261417-4pf5nsw2 322 5 subunits subunit NNS cord-261417-4pf5nsw2 322 6 act act VBP cord-261417-4pf5nsw2 322 7 in in IN cord-261417-4pf5nsw2 322 8 concert concert NN cord-261417-4pf5nsw2 322 9 with with IN cord-261417-4pf5nsw2 322 10 Tat Tat NNP cord-261417-4pf5nsw2 322 11 to to TO cord-261417-4pf5nsw2 322 12 stimulate stimulate VB cord-261417-4pf5nsw2 322 13 human human JJ cord-261417-4pf5nsw2 322 14 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 322 15 virus virus NN cord-261417-4pf5nsw2 322 16 type type NN cord-261417-4pf5nsw2 322 17 1 1 CD cord-261417-4pf5nsw2 322 18 transcription transcription NN cord-261417-4pf5nsw2 322 19 Host host NN cord-261417-4pf5nsw2 322 20 control control NN cord-261417-4pf5nsw2 322 21 of of IN cord-261417-4pf5nsw2 322 22 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 322 23 parasitism parasitism NN cord-261417-4pf5nsw2 322 24 in in IN cord-261417-4pf5nsw2 322 25 T t NN cord-261417-4pf5nsw2 322 26 cells cell NNS cord-261417-4pf5nsw2 322 27 by by IN cord-261417-4pf5nsw2 322 28 the the DT cord-261417-4pf5nsw2 322 29 nuclear nuclear JJ cord-261417-4pf5nsw2 322 30 factor factor NN cord-261417-4pf5nsw2 322 31 of of IN cord-261417-4pf5nsw2 322 32 activated activate VBN cord-261417-4pf5nsw2 322 33 T T NNP cord-261417-4pf5nsw2 322 34 cells cell NNS cord-261417-4pf5nsw2 322 35 Functional functional JJ cord-261417-4pf5nsw2 322 36 roles role NNS cord-261417-4pf5nsw2 322 37 for for IN cord-261417-4pf5nsw2 322 38 the the DT cord-261417-4pf5nsw2 322 39 TATA TATA NNP cord-261417-4pf5nsw2 322 40 promoter promoter NN cord-261417-4pf5nsw2 322 41 and and CC cord-261417-4pf5nsw2 322 42 enhancers enhancer NNS cord-261417-4pf5nsw2 322 43 in in IN cord-261417-4pf5nsw2 322 44 basal basal NN cord-261417-4pf5nsw2 322 45 and and CC cord-261417-4pf5nsw2 322 46 Tat tat NN cord-261417-4pf5nsw2 322 47 - - HYPH cord-261417-4pf5nsw2 322 48 induced induce VBN cord-261417-4pf5nsw2 322 49 expression expression NN cord-261417-4pf5nsw2 322 50 of of IN cord-261417-4pf5nsw2 322 51 the the DT cord-261417-4pf5nsw2 322 52 human human JJ cord-261417-4pf5nsw2 322 53 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 322 54 virus virus NN cord-261417-4pf5nsw2 322 55 type type NN cord-261417-4pf5nsw2 322 56 1 1 CD cord-261417-4pf5nsw2 322 57 long long JJ cord-261417-4pf5nsw2 322 58 terminal terminal NN cord-261417-4pf5nsw2 322 59 repeat repeat NN cord-261417-4pf5nsw2 322 60 Human human JJ cord-261417-4pf5nsw2 322 61 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 322 62 virus virus NN cord-261417-4pf5nsw2 322 63 type type NN cord-261417-4pf5nsw2 322 64 1 1 CD cord-261417-4pf5nsw2 322 65 subtypes subtype NNS cord-261417-4pf5nsw2 322 66 have have VBP cord-261417-4pf5nsw2 322 67 a a DT cord-261417-4pf5nsw2 322 68 distinct distinct JJ cord-261417-4pf5nsw2 322 69 long long JJ cord-261417-4pf5nsw2 322 70 terminal terminal NN cord-261417-4pf5nsw2 322 71 repeat repeat NN cord-261417-4pf5nsw2 322 72 that that WDT cord-261417-4pf5nsw2 322 73 determines determine VBZ cord-261417-4pf5nsw2 322 74 the the DT cord-261417-4pf5nsw2 322 75 replication replication NN cord-261417-4pf5nsw2 322 76 rate rate NN cord-261417-4pf5nsw2 322 77 in in IN cord-261417-4pf5nsw2 322 78 a a DT cord-261417-4pf5nsw2 322 79 host host NN cord-261417-4pf5nsw2 322 80 - - HYPH cord-261417-4pf5nsw2 322 81 cell cell NN cord-261417-4pf5nsw2 322 82 - - HYPH cord-261417-4pf5nsw2 322 83 specific specific JJ cord-261417-4pf5nsw2 322 84 manner manner JJ cord-261417-4pf5nsw2 322 85 Functional functional JJ cord-261417-4pf5nsw2 322 86 differences difference NNS cord-261417-4pf5nsw2 322 87 between between IN cord-261417-4pf5nsw2 322 88 the the DT cord-261417-4pf5nsw2 322 89 long long JJ cord-261417-4pf5nsw2 322 90 terminal terminal NN cord-261417-4pf5nsw2 322 91 repeat repeat NN cord-261417-4pf5nsw2 322 92 transcriptional transcriptional JJ cord-261417-4pf5nsw2 322 93 promoters promoter NNS cord-261417-4pf5nsw2 322 94 of of IN cord-261417-4pf5nsw2 322 95 human human JJ cord-261417-4pf5nsw2 322 96 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 322 97 virus virus NN cord-261417-4pf5nsw2 322 98 type type NN cord-261417-4pf5nsw2 322 99 1 1 CD cord-261417-4pf5nsw2 322 100 subtypes subtype NNS cord-261417-4pf5nsw2 322 101 a a DT cord-261417-4pf5nsw2 322 102 through through IN cord-261417-4pf5nsw2 322 103 g g NN cord-261417-4pf5nsw2 323 1 The the DT cord-261417-4pf5nsw2 323 2 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 323 3 Tat Tat NNP cord-261417-4pf5nsw2 323 4 protein protein NN cord-261417-4pf5nsw2 323 5 has have VBZ cord-261417-4pf5nsw2 323 6 a a DT cord-261417-4pf5nsw2 323 7 versatile versatile JJ cord-261417-4pf5nsw2 323 8 role role NN cord-261417-4pf5nsw2 323 9 in in IN cord-261417-4pf5nsw2 323 10 activating activate VBG cord-261417-4pf5nsw2 323 11 viral viral JJ cord-261417-4pf5nsw2 323 12 transcription transcription NN cord-261417-4pf5nsw2 323 13 Activation Activation NNP cord-261417-4pf5nsw2 323 14 of of IN cord-261417-4pf5nsw2 323 15 the the DT cord-261417-4pf5nsw2 323 16 aids aids NNP cord-261417-4pf5nsw2 323 17 retrovirus retrovirus NN cord-261417-4pf5nsw2 323 18 promoter promoter NN cord-261417-4pf5nsw2 323 19 by by IN cord-261417-4pf5nsw2 323 20 the the DT cord-261417-4pf5nsw2 323 21 cellular cellular JJ cord-261417-4pf5nsw2 323 22 transcription transcription NN cord-261417-4pf5nsw2 323 23 factor factor NN cord-261417-4pf5nsw2 323 24 , , , cord-261417-4pf5nsw2 323 25 SP1 SP1 NNP cord-261417-4pf5nsw2 323 26 . . . cord-261417-4pf5nsw2 324 1 Science Science NNP cord-261417-4pf5nsw2 324 2 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 324 3 core core NN cord-261417-4pf5nsw2 324 4 promoter promoter NN cord-261417-4pf5nsw2 324 5 lacks lack VBZ cord-261417-4pf5nsw2 324 6 a a DT cord-261417-4pf5nsw2 324 7 simple simple JJ cord-261417-4pf5nsw2 324 8 initiator initiator NN cord-261417-4pf5nsw2 324 9 element element NN cord-261417-4pf5nsw2 324 10 but but CC cord-261417-4pf5nsw2 324 11 contains contain VBZ cord-261417-4pf5nsw2 324 12 a a DT cord-261417-4pf5nsw2 324 13 bipartite bipartite JJ cord-261417-4pf5nsw2 324 14 activator activator NN cord-261417-4pf5nsw2 324 15 at at IN cord-261417-4pf5nsw2 324 16 the the DT cord-261417-4pf5nsw2 324 17 transcription transcription NN cord-261417-4pf5nsw2 324 18 start start NN cord-261417-4pf5nsw2 324 19 site site NN cord-261417-4pf5nsw2 324 20 Promoter promoter NN cord-261417-4pf5nsw2 324 21 clearance clearance NN cord-261417-4pf5nsw2 324 22 by by IN cord-261417-4pf5nsw2 324 23 RNA RNA NNP cord-261417-4pf5nsw2 324 24 polymerase polymerase NN cord-261417-4pf5nsw2 324 25 II II NNP cord-261417-4pf5nsw2 324 26 Anti Anti NNP cord-261417-4pf5nsw2 324 27 - - NN cord-261417-4pf5nsw2 324 28 termination termination NN cord-261417-4pf5nsw2 324 29 of of IN cord-261417-4pf5nsw2 324 30 transcription transcription NN cord-261417-4pf5nsw2 324 31 within within IN cord-261417-4pf5nsw2 324 32 the the DT cord-261417-4pf5nsw2 324 33 long long JJ cord-261417-4pf5nsw2 324 34 terminal terminal NN cord-261417-4pf5nsw2 324 35 repeat repeat NN cord-261417-4pf5nsw2 324 36 of of IN cord-261417-4pf5nsw2 324 37 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 324 38 by by IN cord-261417-4pf5nsw2 324 39 Tat Tat NNP cord-261417-4pf5nsw2 324 40 gene gene NN cord-261417-4pf5nsw2 324 41 product product NN cord-261417-4pf5nsw2 324 42 Transcriptional Transcriptional NNP cord-261417-4pf5nsw2 324 43 pausing pause VBG cord-261417-4pf5nsw2 324 44 at at IN cord-261417-4pf5nsw2 324 45 +62 +62 NNP cord-261417-4pf5nsw2 324 46 of of IN cord-261417-4pf5nsw2 325 1 the the DT cord-261417-4pf5nsw2 325 2 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 325 3 nascent nascent JJ cord-261417-4pf5nsw2 325 4 RNA RNA NNP cord-261417-4pf5nsw2 325 5 modulates modulate VBZ cord-261417-4pf5nsw2 325 6 formation formation NN cord-261417-4pf5nsw2 325 7 of of IN cord-261417-4pf5nsw2 325 8 the the DT cord-261417-4pf5nsw2 325 9 TAR TAR NNP cord-261417-4pf5nsw2 325 10 RNA RNA NNP cord-261417-4pf5nsw2 325 11 structure structure NN cord-261417-4pf5nsw2 325 12 DSIF DSIF NNP cord-261417-4pf5nsw2 325 13 and and CC cord-261417-4pf5nsw2 325 14 NELF NELF NNP cord-261417-4pf5nsw2 325 15 interact interact VBP cord-261417-4pf5nsw2 325 16 with with IN cord-261417-4pf5nsw2 325 17 RNA RNA NNP cord-261417-4pf5nsw2 325 18 polymerase polymerase NN cord-261417-4pf5nsw2 325 19 II II NNP cord-261417-4pf5nsw2 325 20 elongation elongation NN cord-261417-4pf5nsw2 325 21 complex complex NN cord-261417-4pf5nsw2 325 22 and and CC cord-261417-4pf5nsw2 326 1 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 326 2 Tat Tat NNP cord-261417-4pf5nsw2 326 3 stimulates stimulate VBZ cord-261417-4pf5nsw2 326 4 P p NN cord-261417-4pf5nsw2 326 5 - - HYPH cord-261417-4pf5nsw2 326 6 TEFb TEFb NNS cord-261417-4pf5nsw2 326 7 - - HYPH cord-261417-4pf5nsw2 326 8 mediated mediate VBN cord-261417-4pf5nsw2 326 9 phosphorylation phosphorylation NN cord-261417-4pf5nsw2 326 10 of of IN cord-261417-4pf5nsw2 326 11 RNA RNA NNP cord-261417-4pf5nsw2 326 12 polymerase polymerase NN cord-261417-4pf5nsw2 326 13 II II NNP cord-261417-4pf5nsw2 326 14 and and CC cord-261417-4pf5nsw2 326 15 DSIF DSIF NNP cord-261417-4pf5nsw2 326 16 during during IN cord-261417-4pf5nsw2 326 17 transcription transcription NN cord-261417-4pf5nsw2 326 18 elongation elongation NN cord-261417-4pf5nsw2 326 19 Negative negative JJ cord-261417-4pf5nsw2 326 20 elongation elongation NN cord-261417-4pf5nsw2 326 21 factor factor NN cord-261417-4pf5nsw2 326 22 ( ( -LRB- cord-261417-4pf5nsw2 326 23 NELF NELF NNP cord-261417-4pf5nsw2 326 24 ) ) -RRB- cord-261417-4pf5nsw2 327 1 coordinates coordinates NNP cord-261417-4pf5nsw2 327 2 RNA RNA NNP cord-261417-4pf5nsw2 327 3 polymerase polymerase NN cord-261417-4pf5nsw2 327 4 II II NNP cord-261417-4pf5nsw2 327 5 pausing pause VBG cord-261417-4pf5nsw2 327 6 , , , cord-261417-4pf5nsw2 327 7 premature premature JJ cord-261417-4pf5nsw2 327 8 termination termination NN cord-261417-4pf5nsw2 327 9 , , , cord-261417-4pf5nsw2 327 10 and and CC cord-261417-4pf5nsw2 327 11 chromatin chromatin NN cord-261417-4pf5nsw2 327 12 remodeling remodeling NN cord-261417-4pf5nsw2 327 13 to to TO cord-261417-4pf5nsw2 327 14 regulate regulate VB cord-261417-4pf5nsw2 327 15 HIV HIV NNP cord-261417-4pf5nsw2 327 16 transcription transcription NN cord-261417-4pf5nsw2 327 17 Roles Roles NNPS cord-261417-4pf5nsw2 327 18 of of IN cord-261417-4pf5nsw2 327 19 RNA RNA NNP cord-261417-4pf5nsw2 327 20 : : : cord-261417-4pf5nsw2 327 21 DNA dna NN cord-261417-4pf5nsw2 327 22 hybrid hybrid NN cord-261417-4pf5nsw2 327 23 stability stability NN cord-261417-4pf5nsw2 327 24 , , , cord-261417-4pf5nsw2 327 25 RNA RNA NNP cord-261417-4pf5nsw2 327 26 structure structure NN cord-261417-4pf5nsw2 327 27 , , , cord-261417-4pf5nsw2 327 28 and and CC cord-261417-4pf5nsw2 327 29 active active JJ cord-261417-4pf5nsw2 327 30 site site NN cord-261417-4pf5nsw2 327 31 conformation conformation NN cord-261417-4pf5nsw2 327 32 in in IN cord-261417-4pf5nsw2 327 33 pausing pause VBG cord-261417-4pf5nsw2 327 34 by by IN cord-261417-4pf5nsw2 327 35 human human JJ cord-261417-4pf5nsw2 327 36 RNA RNA NNP cord-261417-4pf5nsw2 327 37 polymerase polymerase NN cord-261417-4pf5nsw2 328 1 II II NNP cord-261417-4pf5nsw2 328 2 A a DT cord-261417-4pf5nsw2 328 3 pause pause NN cord-261417-4pf5nsw2 328 4 sequence sequence NN cord-261417-4pf5nsw2 328 5 enriched enrich VBN cord-261417-4pf5nsw2 328 6 at at IN cord-261417-4pf5nsw2 328 7 translation translation NN cord-261417-4pf5nsw2 328 8 start start NN cord-261417-4pf5nsw2 328 9 sites site NNS cord-261417-4pf5nsw2 328 10 drives drive VBZ cord-261417-4pf5nsw2 328 11 transcription transcription NN cord-261417-4pf5nsw2 328 12 dynamics dynamic NNS cord-261417-4pf5nsw2 328 13 in in IN cord-261417-4pf5nsw2 328 14 vivo vivo NNP cord-261417-4pf5nsw2 328 15 RNA RNA NNP cord-261417-4pf5nsw2 328 16 polymerase polymerase NN cord-261417-4pf5nsw2 328 17 switches switch VBZ cord-261417-4pf5nsw2 328 18 between between IN cord-261417-4pf5nsw2 328 19 inactivated inactivate VBN cord-261417-4pf5nsw2 328 20 and and CC cord-261417-4pf5nsw2 328 21 activated activate VBN cord-261417-4pf5nsw2 328 22 states state NNS cord-261417-4pf5nsw2 328 23 by by IN cord-261417-4pf5nsw2 328 24 translocating translocate VBG cord-261417-4pf5nsw2 328 25 back back RB cord-261417-4pf5nsw2 328 26 and and CC cord-261417-4pf5nsw2 328 27 forth forth RB cord-261417-4pf5nsw2 328 28 along along IN cord-261417-4pf5nsw2 328 29 the the DT cord-261417-4pf5nsw2 328 30 DNA dna NN cord-261417-4pf5nsw2 328 31 and and CC cord-261417-4pf5nsw2 328 32 the the DT cord-261417-4pf5nsw2 328 33 RNA RNA NNP cord-261417-4pf5nsw2 328 34 The the DT cord-261417-4pf5nsw2 328 35 TAR TAR NNP cord-261417-4pf5nsw2 328 36 hairpin hairpin NN cord-261417-4pf5nsw2 328 37 of of IN cord-261417-4pf5nsw2 328 38 human human JJ cord-261417-4pf5nsw2 328 39 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 328 40 virus virus NN cord-261417-4pf5nsw2 328 41 type type NN cord-261417-4pf5nsw2 328 42 1 1 CD cord-261417-4pf5nsw2 328 43 can can MD cord-261417-4pf5nsw2 328 44 be be VB cord-261417-4pf5nsw2 328 45 deleted delete VBN cord-261417-4pf5nsw2 328 46 when when WRB cord-261417-4pf5nsw2 328 47 not not RB cord-261417-4pf5nsw2 328 48 required require VBN cord-261417-4pf5nsw2 328 49 for for IN cord-261417-4pf5nsw2 328 50 Tat tat NN cord-261417-4pf5nsw2 328 51 - - HYPH cord-261417-4pf5nsw2 328 52 mediated mediate VBN cord-261417-4pf5nsw2 328 53 activation activation NN cord-261417-4pf5nsw2 328 54 of of IN cord-261417-4pf5nsw2 328 55 transcription transcription NN cord-261417-4pf5nsw2 328 56 RNA RNA NNP cord-261417-4pf5nsw2 328 57 - - HYPH cord-261417-4pf5nsw2 328 58 mediated mediate VBN cord-261417-4pf5nsw2 328 59 displacement displacement NN cord-261417-4pf5nsw2 328 60 of of IN cord-261417-4pf5nsw2 328 61 an an DT cord-261417-4pf5nsw2 328 62 inhibitory inhibitory JJ cord-261417-4pf5nsw2 328 63 SNRNP SNRNP NNP cord-261417-4pf5nsw2 328 64 complex complex JJ cord-261417-4pf5nsw2 329 1 activates activate VBZ cord-261417-4pf5nsw2 329 2 transcription transcription NN cord-261417-4pf5nsw2 329 3 elongation elongation NN cord-261417-4pf5nsw2 330 1 A a DT cord-261417-4pf5nsw2 330 2 human human JJ cord-261417-4pf5nsw2 330 3 immunodeficiency immunodeficiency NN cord-261417-4pf5nsw2 330 4 virus virus NN cord-261417-4pf5nsw2 330 5 type type NN cord-261417-4pf5nsw2 331 1 1 1 CD cord-261417-4pf5nsw2 331 2 Tat tat NN cord-261417-4pf5nsw2 331 3 -like -like NN cord-261417-4pf5nsw2 331 4 arginine arginine NN cord-261417-4pf5nsw2 331 5 - - HYPH cord-261417-4pf5nsw2 331 6 rich rich JJ cord-261417-4pf5nsw2 331 7 RNA rna NN cord-261417-4pf5nsw2 331 8 - - HYPH cord-261417-4pf5nsw2 331 9 binding bind VBG cord-261417-4pf5nsw2 331 10 domain domain NN cord-261417-4pf5nsw2 331 11 is be VBZ cord-261417-4pf5nsw2 331 12 essential essential JJ cord-261417-4pf5nsw2 331 13 for for IN cord-261417-4pf5nsw2 331 14 HEXIM1 hexim1 PRP cord-261417-4pf5nsw2 331 15 to to TO cord-261417-4pf5nsw2 331 16 inhibit inhibit VB cord-261417-4pf5nsw2 331 17 RNA RNA NNP cord-261417-4pf5nsw2 331 18 polymerase polymerase NN cord-261417-4pf5nsw2 331 19 II ii CD cord-261417-4pf5nsw2 331 20 transcription transcription NN cord-261417-4pf5nsw2 331 21 through through IN cord-261417-4pf5nsw2 331 22 7SK 7sk CD cord-261417-4pf5nsw2 331 23 snRNA snrna RB cord-261417-4pf5nsw2 331 24 - - HYPH cord-261417-4pf5nsw2 331 25 mediated mediate VBN cord-261417-4pf5nsw2 331 26 inactivation inactivation NN cord-261417-4pf5nsw2 331 27 of of IN cord-261417-4pf5nsw2 331 28 P p NN cord-261417-4pf5nsw2 331 29 - - HYPH cord-261417-4pf5nsw2 331 30 TEFb TEFb NNS cord-261417-4pf5nsw2 331 31 Controlling control VBG cord-261417-4pf5nsw2 331 32 cellular cellular JJ cord-261417-4pf5nsw2 331 33 P p NN cord-261417-4pf5nsw2 331 34 - - HYPH cord-261417-4pf5nsw2 331 35 TEFb TEFb NNS cord-261417-4pf5nsw2 331 36 activity activity NN cord-261417-4pf5nsw2 331 37 by by IN cord-261417-4pf5nsw2 331 38 the the DT cord-261417-4pf5nsw2 331 39 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 331 40 transcriptional transcriptional NN cord-261417-4pf5nsw2 331 41 transactivator transactivator NN cord-261417-4pf5nsw2 331 42 Tat Tat NNP cord-261417-4pf5nsw2 331 43 Identification Identification NNP cord-261417-4pf5nsw2 331 44 of of IN cord-261417-4pf5nsw2 331 45 a a DT cord-261417-4pf5nsw2 331 46 Cyclin Cyclin NNP cord-261417-4pf5nsw2 331 47 T t NN cord-261417-4pf5nsw2 331 48 - - HYPH cord-261417-4pf5nsw2 331 49 binding bind VBG cord-261417-4pf5nsw2 331 50 domain domain NN cord-261417-4pf5nsw2 331 51 in in IN cord-261417-4pf5nsw2 331 52 HEXIM1 hexim1 JJ cord-261417-4pf5nsw2 331 53 and and CC cord-261417-4pf5nsw2 331 54 biochemical biochemical JJ cord-261417-4pf5nsw2 331 55 analysis analysis NN cord-261417-4pf5nsw2 331 56 of of IN cord-261417-4pf5nsw2 331 57 its -PRON- PRP$ cord-261417-4pf5nsw2 331 58 binding bind VBG cord-261417-4pf5nsw2 331 59 competition competition NN cord-261417-4pf5nsw2 331 60 with with IN cord-261417-4pf5nsw2 331 61 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 331 62 Tat Tat NNP cord-261417-4pf5nsw2 331 63 Bensaude Bensaude NNP cord-261417-4pf5nsw2 331 64 , , , cord-261417-4pf5nsw2 331 65 O. O. NNP cord-261417-4pf5nsw2 331 66 MAQ1 MAQ1 NNP cord-261417-4pf5nsw2 331 67 and and CC cord-261417-4pf5nsw2 331 68 7SK 7sk CD cord-261417-4pf5nsw2 331 69 RNA RNA NNP cord-261417-4pf5nsw2 331 70 interact interact VBP cord-261417-4pf5nsw2 331 71 with with IN cord-261417-4pf5nsw2 331 72 CDK9 CDK9 NNP cord-261417-4pf5nsw2 331 73 / / SYM cord-261417-4pf5nsw2 331 74 Cyclin Cyclin NNP cord-261417-4pf5nsw2 331 75 T T NNP cord-261417-4pf5nsw2 331 76 complexes complex NNS cord-261417-4pf5nsw2 331 77 in in IN cord-261417-4pf5nsw2 331 78 a a DT cord-261417-4pf5nsw2 331 79 transcription transcription NN cord-261417-4pf5nsw2 331 80 - - HYPH cord-261417-4pf5nsw2 331 81 dependent dependent JJ cord-261417-4pf5nsw2 331 82 manner manner NN cord-261417-4pf5nsw2 332 1 Tat Tat NNP cord-261417-4pf5nsw2 332 2 competes compete VBZ cord-261417-4pf5nsw2 332 3 with with IN cord-261417-4pf5nsw2 332 4 HEXIM1 hexim1 PRP cord-261417-4pf5nsw2 332 5 to to TO cord-261417-4pf5nsw2 332 6 increase increase VB cord-261417-4pf5nsw2 332 7 the the DT cord-261417-4pf5nsw2 332 8 active active JJ cord-261417-4pf5nsw2 332 9 pool pool NN cord-261417-4pf5nsw2 332 10 of of IN cord-261417-4pf5nsw2 332 11 P p NN cord-261417-4pf5nsw2 332 12 - - HYPH cord-261417-4pf5nsw2 332 13 TEFb TEFb NNS cord-261417-4pf5nsw2 332 14 for for IN cord-261417-4pf5nsw2 332 15 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 332 16 transcription transcription NN cord-261417-4pf5nsw2 332 17 Human Human NNP cord-261417-4pf5nsw2 332 18 T T NNP cord-261417-4pf5nsw2 332 19 - - HYPH cord-261417-4pf5nsw2 332 20 lymphotropic lymphotropic NNP cord-261417-4pf5nsw2 332 21 virus virus NN cord-261417-4pf5nsw2 332 22 type type NN cord-261417-4pf5nsw2 332 23 1 1 CD cord-261417-4pf5nsw2 332 24 TAX tax NN cord-261417-4pf5nsw2 332 25 protein protein NN cord-261417-4pf5nsw2 332 26 complexes complex NNS cord-261417-4pf5nsw2 332 27 with with IN cord-261417-4pf5nsw2 332 28 P p NN cord-261417-4pf5nsw2 332 29 - - HYPH cord-261417-4pf5nsw2 332 30 TEFb TEFb NNS cord-261417-4pf5nsw2 332 31 and and CC cord-261417-4pf5nsw2 332 32 competes compete VBZ cord-261417-4pf5nsw2 332 33 for for IN cord-261417-4pf5nsw2 332 34 BRD4 BRD4 NNP cord-261417-4pf5nsw2 332 35 and and CC cord-261417-4pf5nsw2 332 36 7SK 7sk CD cord-261417-4pf5nsw2 332 37 SNRNP SNRNP NNP cord-261417-4pf5nsw2 332 38 / / SYM cord-261417-4pf5nsw2 332 39 HEXIM1 HEXIM1 VBN cord-261417-4pf5nsw2 332 40 binding bind VBG cord-261417-4pf5nsw2 332 41 Tax tax NN cord-261417-4pf5nsw2 333 1 interacts interact VBZ cord-261417-4pf5nsw2 333 2 with with IN cord-261417-4pf5nsw2 333 3 P p NN cord-261417-4pf5nsw2 333 4 - - HYPH cord-261417-4pf5nsw2 333 5 TEFb TEFb NNS cord-261417-4pf5nsw2 333 6 in in IN cord-261417-4pf5nsw2 333 7 a a DT cord-261417-4pf5nsw2 333 8 novel novel JJ cord-261417-4pf5nsw2 333 9 manner manner NN cord-261417-4pf5nsw2 333 10 to to TO cord-261417-4pf5nsw2 333 11 stimulate stimulate VB cord-261417-4pf5nsw2 333 12 human human JJ cord-261417-4pf5nsw2 333 13 T T NNP cord-261417-4pf5nsw2 333 14 - - HYPH cord-261417-4pf5nsw2 333 15 lymphotropic lymphotropic NNP cord-261417-4pf5nsw2 333 16 virus virus NN cord-261417-4pf5nsw2 333 17 type type NN cord-261417-4pf5nsw2 333 18 1 1 CD cord-261417-4pf5nsw2 333 19 transcription transcription NN cord-261417-4pf5nsw2 333 20 Epstein Epstein NNP cord-261417-4pf5nsw2 333 21 - - HYPH cord-261417-4pf5nsw2 333 22 barr barr NNP cord-261417-4pf5nsw2 333 23 virus virus NN cord-261417-4pf5nsw2 333 24 : : : cord-261417-4pf5nsw2 334 1 40 40 CD cord-261417-4pf5nsw2 334 2 years year NNS cord-261417-4pf5nsw2 334 3 on on IN cord-261417-4pf5nsw2 334 4 Epstein Epstein NNP cord-261417-4pf5nsw2 334 5 barr barr NNP cord-261417-4pf5nsw2 334 6 virus virus NN cord-261417-4pf5nsw2 334 7 - - HYPH cord-261417-4pf5nsw2 334 8 associated associate VBN cord-261417-4pf5nsw2 334 9 tumours tumour NNS cord-261417-4pf5nsw2 334 10 : : : cord-261417-4pf5nsw2 334 11 An an DT cord-261417-4pf5nsw2 334 12 update update NN cord-261417-4pf5nsw2 334 13 for for IN cord-261417-4pf5nsw2 334 14 the the DT cord-261417-4pf5nsw2 334 15 attention attention NN cord-261417-4pf5nsw2 334 16 of of IN cord-261417-4pf5nsw2 334 17 the the DT cord-261417-4pf5nsw2 334 18 working work VBG cord-261417-4pf5nsw2 334 19 pathologist pathologist NN cord-261417-4pf5nsw2 334 20 Viral Viral NNP cord-261417-4pf5nsw2 334 21 noncoding noncoding JJ cord-261417-4pf5nsw2 334 22 RNAs rna NNS cord-261417-4pf5nsw2 334 23 : : : cord-261417-4pf5nsw2 334 24 More More JJR cord-261417-4pf5nsw2 334 25 surprises surprise NNS cord-261417-4pf5nsw2 334 26 Genome genome NN cord-261417-4pf5nsw2 334 27 - - HYPH cord-261417-4pf5nsw2 334 28 wide wide JJ cord-261417-4pf5nsw2 334 29 analyses analysis NNS cord-261417-4pf5nsw2 334 30 of of IN cord-261417-4pf5nsw2 334 31 Epstein Epstein NNP cord-261417-4pf5nsw2 334 32 - - HYPH cord-261417-4pf5nsw2 334 33 Barr Barr NNP cord-261417-4pf5nsw2 334 34 virus virus NN cord-261417-4pf5nsw2 334 35 reveal reveal VBP cord-261417-4pf5nsw2 334 36 conserved conserve VBN cord-261417-4pf5nsw2 334 37 RNA RNA NNP cord-261417-4pf5nsw2 334 38 structures structure NNS cord-261417-4pf5nsw2 334 39 and and CC cord-261417-4pf5nsw2 334 40 a a DT cord-261417-4pf5nsw2 334 41 novel novel JJ cord-261417-4pf5nsw2 334 42 stable stable JJ cord-261417-4pf5nsw2 334 43 intronic intronic JJ cord-261417-4pf5nsw2 334 44 sequence sequence NN cord-261417-4pf5nsw2 334 45 RNA RNA NNP cord-261417-4pf5nsw2 334 46 Epstein Epstein NNP cord-261417-4pf5nsw2 334 47 - - HYPH cord-261417-4pf5nsw2 334 48 Barr Barr NNP cord-261417-4pf5nsw2 334 49 virus virus NN cord-261417-4pf5nsw2 334 50 noncoding noncoding JJ cord-261417-4pf5nsw2 334 51 RNAs rna NNS cord-261417-4pf5nsw2 334 52 are be VBP cord-261417-4pf5nsw2 334 53 confined confine VBN cord-261417-4pf5nsw2 334 54 to to IN cord-261417-4pf5nsw2 334 55 the the DT cord-261417-4pf5nsw2 334 56 nucleus nucleus NN cord-261417-4pf5nsw2 334 57 , , , cord-261417-4pf5nsw2 334 58 whereas whereas IN cord-261417-4pf5nsw2 334 59 their -PRON- PRP$ cord-261417-4pf5nsw2 334 60 partner partner NN cord-261417-4pf5nsw2 334 61 , , , cord-261417-4pf5nsw2 334 62 the the DT cord-261417-4pf5nsw2 334 63 human human JJ cord-261417-4pf5nsw2 334 64 La La NNP cord-261417-4pf5nsw2 334 65 protein protein NN cord-261417-4pf5nsw2 334 66 , , , cord-261417-4pf5nsw2 334 67 undergoes undergo VBZ cord-261417-4pf5nsw2 334 68 nucleocytoplasmic nucleocytoplasmic NNP cord-261417-4pf5nsw2 334 69 shuttling shuttle VBG cord-261417-4pf5nsw2 334 70 Laboratory laboratory NN cord-261417-4pf5nsw2 334 71 assays assay NNS cord-261417-4pf5nsw2 334 72 for for IN cord-261417-4pf5nsw2 334 73 Epstein Epstein NNP cord-261417-4pf5nsw2 334 74 - - HYPH cord-261417-4pf5nsw2 334 75 Barr Barr NNP cord-261417-4pf5nsw2 334 76 virus virus NN cord-261417-4pf5nsw2 334 77 - - HYPH cord-261417-4pf5nsw2 334 78 related relate VBN cord-261417-4pf5nsw2 334 79 disease disease NN cord-261417-4pf5nsw2 335 1 Covalently covalently RB cord-261417-4pf5nsw2 335 2 closed close VBD cord-261417-4pf5nsw2 335 3 circular circular JJ cord-261417-4pf5nsw2 335 4 duplex duplex JJ cord-261417-4pf5nsw2 335 5 DNA dna NN cord-261417-4pf5nsw2 335 6 of of IN cord-261417-4pf5nsw2 335 7 Epstein Epstein NNP cord-261417-4pf5nsw2 335 8 - - HYPH cord-261417-4pf5nsw2 335 9 Barr Barr NNP cord-261417-4pf5nsw2 335 10 virus virus NN cord-261417-4pf5nsw2 335 11 in in IN cord-261417-4pf5nsw2 335 12 a a DT cord-261417-4pf5nsw2 335 13 human human JJ cord-261417-4pf5nsw2 335 14 lymphoid lymphoid JJ cord-261417-4pf5nsw2 335 15 cell cell NN cord-261417-4pf5nsw2 335 16 line line NN cord-261417-4pf5nsw2 336 1 An an DT cord-261417-4pf5nsw2 336 2 atlas atlas NN cord-261417-4pf5nsw2 336 3 of of IN cord-261417-4pf5nsw2 336 4 the the DT cord-261417-4pf5nsw2 336 5 Epstein Epstein NNP cord-261417-4pf5nsw2 336 6 - - HYPH cord-261417-4pf5nsw2 336 7 Barr Barr NNP cord-261417-4pf5nsw2 336 8 virus virus NN cord-261417-4pf5nsw2 336 9 transcriptome transcriptome NN cord-261417-4pf5nsw2 336 10 and and CC cord-261417-4pf5nsw2 336 11 epigenome epigenome NN cord-261417-4pf5nsw2 336 12 reveals reveal VBZ cord-261417-4pf5nsw2 336 13 host host NN cord-261417-4pf5nsw2 336 14 - - HYPH cord-261417-4pf5nsw2 336 15 virus virus NN cord-261417-4pf5nsw2 336 16 regulatory regulatory JJ cord-261417-4pf5nsw2 336 17 interactions interaction NNS cord-261417-4pf5nsw2 337 1 Noncoding Noncoding NNP cord-261417-4pf5nsw2 337 2 RNA RNA NNP cord-261417-4pf5nsw2 337 3 - - HYPH cord-261417-4pf5nsw2 337 4 guided guide VBN cord-261417-4pf5nsw2 337 5 recruitment recruitment NN cord-261417-4pf5nsw2 337 6 of of IN cord-261417-4pf5nsw2 337 7 transcription transcription NN cord-261417-4pf5nsw2 337 8 factors factor NNS cord-261417-4pf5nsw2 337 9 : : : cord-261417-4pf5nsw2 337 10 A a DT cord-261417-4pf5nsw2 337 11 prevalent prevalent JJ cord-261417-4pf5nsw2 337 12 but but CC cord-261417-4pf5nsw2 337 13 undocumented undocumented JJ cord-261417-4pf5nsw2 337 14 mechanism mechanism NN cord-261417-4pf5nsw2 337 15 ? ? . cord-261417-4pf5nsw2 338 1 EBV EBV NNP cord-261417-4pf5nsw2 338 2 noncoding noncoding NNP cord-261417-4pf5nsw2 338 3 RNA RNA NNP cord-261417-4pf5nsw2 338 4 EBER2 EBER2 NNP cord-261417-4pf5nsw2 338 5 interacts interact VBZ cord-261417-4pf5nsw2 338 6 with with IN cord-261417-4pf5nsw2 338 7 host host NN cord-261417-4pf5nsw2 338 8 RNA rna NN cord-261417-4pf5nsw2 338 9 - - HYPH cord-261417-4pf5nsw2 338 10 binding bind VBG cord-261417-4pf5nsw2 338 11 proteins protein NNS cord-261417-4pf5nsw2 338 12 to to TO cord-261417-4pf5nsw2 338 13 regulate regulate VB cord-261417-4pf5nsw2 338 14 viral viral JJ cord-261417-4pf5nsw2 338 15 gene gene NN cord-261417-4pf5nsw2 338 16 expression expression NN cord-261417-4pf5nsw2 338 17 A a DT cord-261417-4pf5nsw2 338 18 comprehensive comprehensive JJ cord-261417-4pf5nsw2 338 19 survey survey NN cord-261417-4pf5nsw2 338 20 of of IN cord-261417-4pf5nsw2 338 21 3 3 CD cord-261417-4pf5nsw2 338 22 animal animal NN cord-261417-4pf5nsw2 338 23 miRNA miRNA NNP cord-261417-4pf5nsw2 338 24 modification modification NN cord-261417-4pf5nsw2 338 25 events event NNS cord-261417-4pf5nsw2 338 26 and and CC cord-261417-4pf5nsw2 338 27 a a DT cord-261417-4pf5nsw2 338 28 possible possible JJ cord-261417-4pf5nsw2 338 29 role role NN cord-261417-4pf5nsw2 338 30 for for IN cord-261417-4pf5nsw2 338 31 3 3 CD cord-261417-4pf5nsw2 338 32 adenylation adenylation NN cord-261417-4pf5nsw2 338 33 in in IN cord-261417-4pf5nsw2 338 34 modulating modulate VBG cord-261417-4pf5nsw2 338 35 miRNA miRNA NNP cord-261417-4pf5nsw2 338 36 targeting target VBG cord-261417-4pf5nsw2 338 37 effectiveness effectiveness NN cord-261417-4pf5nsw2 338 38 Transcription transcription NN cord-261417-4pf5nsw2 338 39 termination termination NN cord-261417-4pf5nsw2 338 40 by by IN cord-261417-4pf5nsw2 338 41 nuclear nuclear JJ cord-261417-4pf5nsw2 338 42 RNA RNA NNP cord-261417-4pf5nsw2 339 1 polymerases polymerase NNS cord-261417-4pf5nsw2 339 2 The the DT cord-261417-4pf5nsw2 339 3 biochemistry biochemistry NN cord-261417-4pf5nsw2 339 4 of of IN cord-261417-4pf5nsw2 339 5 polyadenylation polyadenylation NN cord-261417-4pf5nsw2 339 6 RNA RNA NNP cord-261417-4pf5nsw2 339 7 : : : cord-261417-4pf5nsw2 340 1 A a DT cord-261417-4pf5nsw2 340 2 case case NN cord-261417-4pf5nsw2 340 3 of of IN cord-261417-4pf5nsw2 340 4 the the DT cord-261417-4pf5nsw2 340 5 tail tail NN cord-261417-4pf5nsw2 340 6 wagging wag VBG cord-261417-4pf5nsw2 340 7 the the DT cord-261417-4pf5nsw2 340 8 dog dog NN cord-261417-4pf5nsw2 340 9 A)-binding A)-binding NNP cord-261417-4pf5nsw2 340 10 proteins protein NNS cord-261417-4pf5nsw2 340 11 : : : cord-261417-4pf5nsw2 340 12 Structure structure NN cord-261417-4pf5nsw2 340 13 , , , cord-261417-4pf5nsw2 340 14 domain domain NN cord-261417-4pf5nsw2 340 15 organization organization NN cord-261417-4pf5nsw2 340 16 , , , cord-261417-4pf5nsw2 340 17 and and CC cord-261417-4pf5nsw2 340 18 activity activity NN cord-261417-4pf5nsw2 340 19 regulation regulation NN cord-261417-4pf5nsw2 340 20 Uridylation Uridylation NNP cord-261417-4pf5nsw2 340 21 by by IN cord-261417-4pf5nsw2 340 22 TUT4 TUT4 NNP cord-261417-4pf5nsw2 340 23 and and CC cord-261417-4pf5nsw2 340 24 TUT7 TUT7 NNP cord-261417-4pf5nsw2 341 1 marks marks NNP cord-261417-4pf5nsw2 341 2 mRNA mRNA NNP cord-261417-4pf5nsw2 341 3 for for IN cord-261417-4pf5nsw2 341 4 degradation degradation NN cord-261417-4pf5nsw2 341 5 Functional Functional NNP cord-261417-4pf5nsw2 341 6 RNA RNA NNP cord-261417-4pf5nsw2 341 7 elements element NNS cord-261417-4pf5nsw2 341 8 in in IN cord-261417-4pf5nsw2 341 9 the the DT cord-261417-4pf5nsw2 341 10 dengue dengue NN cord-261417-4pf5nsw2 341 11 virus virus NN cord-261417-4pf5nsw2 341 12 genome genome NN cord-261417-4pf5nsw2 341 13 Essential essential JJ cord-261417-4pf5nsw2 341 14 role role NN cord-261417-4pf5nsw2 341 15 of of IN cord-261417-4pf5nsw2 341 16 cyclization cyclization NN cord-261417-4pf5nsw2 341 17 sequences sequence NNS cord-261417-4pf5nsw2 341 18 in in IN cord-261417-4pf5nsw2 341 19 flavivirus flavivirus NNP cord-261417-4pf5nsw2 341 20 RNA RNA NNP cord-261417-4pf5nsw2 341 21 replication replication NN cord-261417-4pf5nsw2 342 1 A a DT cord-261417-4pf5nsw2 342 2 four four CD cord-261417-4pf5nsw2 342 3 - - HYPH cord-261417-4pf5nsw2 342 4 nucleotide nucleotide JJ cord-261417-4pf5nsw2 342 5 translation translation NN cord-261417-4pf5nsw2 342 6 enhancer enhancer NN cord-261417-4pf5nsw2 342 7 in in IN cord-261417-4pf5nsw2 342 8 the the DT cord-261417-4pf5nsw2 342 9 3 3 CD cord-261417-4pf5nsw2 342 10 -terminal -terminal JJ cord-261417-4pf5nsw2 342 11 consensus consensus NN cord-261417-4pf5nsw2 342 12 sequence sequence NN cord-261417-4pf5nsw2 342 13 of of IN cord-261417-4pf5nsw2 342 14 the the DT cord-261417-4pf5nsw2 342 15 nonpolyadenylated nonpolyadenylated JJ cord-261417-4pf5nsw2 342 16 mRNAs mrnas CD cord-261417-4pf5nsw2 342 17 of of IN cord-261417-4pf5nsw2 342 18 rotavirus rotavirus JJ cord-261417-4pf5nsw2 342 19 Base Base NNP cord-261417-4pf5nsw2 342 20 - - HYPH cord-261417-4pf5nsw2 342 21 pairing pairing NN cord-261417-4pf5nsw2 342 22 between between IN cord-261417-4pf5nsw2 342 23 untranslated untranslated JJ cord-261417-4pf5nsw2 342 24 regions region NNS cord-261417-4pf5nsw2 342 25 facilitates facilitate VBZ cord-261417-4pf5nsw2 342 26 translation translation NN cord-261417-4pf5nsw2 342 27 of of IN cord-261417-4pf5nsw2 342 28 uncapped uncapped JJ cord-261417-4pf5nsw2 342 29 , , , cord-261417-4pf5nsw2 342 30 nonpolyadenylated nonpolyadenylated JJ cord-261417-4pf5nsw2 342 31 viral viral JJ cord-261417-4pf5nsw2 342 32 RNA RNA NNP cord-261417-4pf5nsw2 343 1 The the DT cord-261417-4pf5nsw2 343 2 yin yin NNP cord-261417-4pf5nsw2 343 3 and and CC cord-261417-4pf5nsw2 343 4 yang yang NNP cord-261417-4pf5nsw2 343 5 of of IN cord-261417-4pf5nsw2 343 6 hepatitis hepatitis NNP cord-261417-4pf5nsw2 343 7 C C NNP cord-261417-4pf5nsw2 343 8 : : : cord-261417-4pf5nsw2 343 9 Synthesis synthesis NN cord-261417-4pf5nsw2 343 10 and and CC cord-261417-4pf5nsw2 343 11 decay decay NN cord-261417-4pf5nsw2 343 12 of of IN cord-261417-4pf5nsw2 343 13 hepatitis hepatitis NN cord-261417-4pf5nsw2 343 14 C C NNP cord-261417-4pf5nsw2 343 15 virus virus NN cord-261417-4pf5nsw2 343 16 RNA RNA NNP cord-261417-4pf5nsw2 343 17 Regulation Regulation NNP cord-261417-4pf5nsw2 343 18 of of IN cord-261417-4pf5nsw2 343 19 microRNA microRNA NNP cord-261417-4pf5nsw2 343 20 biogenesis biogenesis NN cord-261417-4pf5nsw2 343 21 RNA RNA NNP cord-261417-4pf5nsw2 343 22 virus virus NN cord-261417-4pf5nsw2 343 23 microRNA microRNA NNP cord-261417-4pf5nsw2 343 24 that that WDT cord-261417-4pf5nsw2 343 25 mimics mimic VBZ cord-261417-4pf5nsw2 343 26 a a DT cord-261417-4pf5nsw2 343 27 B b NN cord-261417-4pf5nsw2 343 28 - - HYPH cord-261417-4pf5nsw2 343 29 cell cell NN cord-261417-4pf5nsw2 343 30 oncomiR oncomiR NNP cord-261417-4pf5nsw2 343 31 Identification identification NN cord-261417-4pf5nsw2 343 32 of of IN cord-261417-4pf5nsw2 343 33 novel novel NN cord-261417-4pf5nsw2 343 34 , , , cord-261417-4pf5nsw2 343 35 highly highly RB cord-261417-4pf5nsw2 343 36 expressed express VBN cord-261417-4pf5nsw2 343 37 retroviral retroviral NN cord-261417-4pf5nsw2 343 38 microRNAs microrna NNS cord-261417-4pf5nsw2 343 39 in in IN cord-261417-4pf5nsw2 343 40 cells cell NNS cord-261417-4pf5nsw2 343 41 infected infect VBN cord-261417-4pf5nsw2 343 42 by by IN cord-261417-4pf5nsw2 343 43 bovine bovine JJ cord-261417-4pf5nsw2 343 44 foamy foamy NN cord-261417-4pf5nsw2 343 45 virus virus NN cord-261417-4pf5nsw2 343 46 Tat tat NN cord-261417-4pf5nsw2 343 47 - - HYPH cord-261417-4pf5nsw2 343 48 dependent dependent JJ cord-261417-4pf5nsw2 343 49 production production NN cord-261417-4pf5nsw2 343 50 of of IN cord-261417-4pf5nsw2 343 51 an an DT cord-261417-4pf5nsw2 343 52 HIV-1 HIV-1 NNP cord-261417-4pf5nsw2 343 53 TAR TAR NNP cord-261417-4pf5nsw2 343 54 - - HYPH cord-261417-4pf5nsw2 343 55 encoded encode VBN cord-261417-4pf5nsw2 343 56 miRNA miRNA NNP cord-261417-4pf5nsw2 343 57 - - HYPH cord-261417-4pf5nsw2 343 58 like like JJ cord-261417-4pf5nsw2 343 59 small small JJ cord-261417-4pf5nsw2 343 60 RNA RNA NNP cord-261417-4pf5nsw2 343 61 Severe severe JJ cord-261417-4pf5nsw2 343 62 acute acute JJ cord-261417-4pf5nsw2 343 63 respiratory respiratory JJ cord-261417-4pf5nsw2 343 64 syndrome syndrome NN cord-261417-4pf5nsw2 343 65 coronavirus coronavirus NN cord-261417-4pf5nsw2 343 66 NSP1 NSP1 NNP cord-261417-4pf5nsw2 343 67 protein protein NN cord-261417-4pf5nsw2 344 1 suppresses suppress VBZ cord-261417-4pf5nsw2 344 2 host host NN cord-261417-4pf5nsw2 344 3 gene gene NN cord-261417-4pf5nsw2 344 4 expression expression NN cord-261417-4pf5nsw2 344 5 by by IN cord-261417-4pf5nsw2 344 6 promoting promote VBG cord-261417-4pf5nsw2 344 7 host host NN cord-261417-4pf5nsw2 344 8 mRNA mRNA NNP cord-261417-4pf5nsw2 344 9 degradation degradation NN cord-261417-4pf5nsw2 344 10 A a DT cord-261417-4pf5nsw2 344 11 two two CD cord-261417-4pf5nsw2 344 12 - - HYPH cord-261417-4pf5nsw2 344 13 pronged pronged JJ cord-261417-4pf5nsw2 344 14 strategy strategy NN cord-261417-4pf5nsw2 344 15 to to TO cord-261417-4pf5nsw2 344 16 suppress suppress VB cord-261417-4pf5nsw2 344 17 host host NN cord-261417-4pf5nsw2 344 18 protein protein NN cord-261417-4pf5nsw2 344 19 synthesis synthesis NN cord-261417-4pf5nsw2 344 20 by by IN cord-261417-4pf5nsw2 344 21 SARS SARS NNP cord-261417-4pf5nsw2 344 22 coronavirus coronavirus NN cord-261417-4pf5nsw2 345 1 NSP1 NSP1 NNP cord-261417-4pf5nsw2 345 2 protein protein NN cord-261417-4pf5nsw2 345 3 Herpes Herpes NNP cord-261417-4pf5nsw2 345 4 simplex simplex NN cord-261417-4pf5nsw2 345 5 virus virus NN cord-261417-4pf5nsw2 345 6 - - HYPH cord-261417-4pf5nsw2 345 7 infected infect VBN cord-261417-4pf5nsw2 345 8 cells cell NNS cord-261417-4pf5nsw2 345 9 contain contain VBP cord-261417-4pf5nsw2 345 10 a a DT cord-261417-4pf5nsw2 345 11 function(s function(s NNP cord-261417-4pf5nsw2 345 12 ) ) -RRB- cord-261417-4pf5nsw2 345 13 that that WDT cord-261417-4pf5nsw2 345 14 destabilizes destabilize VBZ cord-261417-4pf5nsw2 345 15 both both DT cord-261417-4pf5nsw2 345 16 host host NN cord-261417-4pf5nsw2 345 17 and and CC cord-261417-4pf5nsw2 345 18 viral viral JJ cord-261417-4pf5nsw2 345 19 mRNAs mrnas CD cord-261417-4pf5nsw2 345 20 Herpes herpes NN cord-261417-4pf5nsw2 345 21 simplex simplex NN cord-261417-4pf5nsw2 345 22 virus virus NN cord-261417-4pf5nsw2 345 23 mutants mutant NNS cord-261417-4pf5nsw2 345 24 defective defective JJ cord-261417-4pf5nsw2 345 25 in in IN cord-261417-4pf5nsw2 345 26 the the DT cord-261417-4pf5nsw2 345 27 virion virion NN cord-261417-4pf5nsw2 345 28 - - HYPH cord-261417-4pf5nsw2 345 29 associated associate VBN cord-261417-4pf5nsw2 345 30 shutoff shutoff NN cord-261417-4pf5nsw2 345 31 of of IN cord-261417-4pf5nsw2 345 32 host host NN cord-261417-4pf5nsw2 345 33 polypeptide polypeptide NN cord-261417-4pf5nsw2 345 34 synthesis synthesis NN cord-261417-4pf5nsw2 345 35 and and CC cord-261417-4pf5nsw2 345 36 exhibiting exhibit VBG cord-261417-4pf5nsw2 345 37 abnormal abnormal JJ cord-261417-4pf5nsw2 345 38 synthesis synthesis NN cord-261417-4pf5nsw2 345 39 of of IN cord-261417-4pf5nsw2 345 40 α α NNP cord-261417-4pf5nsw2 345 41 ( ( -LRB- cord-261417-4pf5nsw2 345 42 immediate immediate JJ cord-261417-4pf5nsw2 345 43 early early JJ cord-261417-4pf5nsw2 345 44 ) ) -RRB- cord-261417-4pf5nsw2 345 45 viral viral JJ cord-261417-4pf5nsw2 345 46 polypeptides polypeptide NNS cord-261417-4pf5nsw2 345 47 Characterization characterization NN cord-261417-4pf5nsw2 345 48 of of IN cord-261417-4pf5nsw2 345 49 a a DT cord-261417-4pf5nsw2 345 50 second second JJ cord-261417-4pf5nsw2 345 51 vaccinia vaccinia NN cord-261417-4pf5nsw2 345 52 virus virus NN cord-261417-4pf5nsw2 345 53 mRNA mrna NN cord-261417-4pf5nsw2 345 54 - - HYPH cord-261417-4pf5nsw2 345 55 decapping decappe VBG cord-261417-4pf5nsw2 345 56 enzyme enzyme NN cord-261417-4pf5nsw2 345 57 conserved conserve VBN cord-261417-4pf5nsw2 345 58 in in IN cord-261417-4pf5nsw2 345 59 poxviruses poxvirus NNS cord-261417-4pf5nsw2 345 60 Vaccinia Vaccinia NNP cord-261417-4pf5nsw2 345 61 virus virus NN cord-261417-4pf5nsw2 345 62 D10 D10 NNP cord-261417-4pf5nsw2 345 63 protein protein NN cord-261417-4pf5nsw2 345 64 has have VBZ cord-261417-4pf5nsw2 345 65 mRNA mrna NN cord-261417-4pf5nsw2 345 66 decapping decapping NN cord-261417-4pf5nsw2 345 67 activity activity NN cord-261417-4pf5nsw2 345 68 , , , cord-261417-4pf5nsw2 345 69 providing provide VBG cord-261417-4pf5nsw2 345 70 a a DT cord-261417-4pf5nsw2 345 71 mechanism mechanism NN cord-261417-4pf5nsw2 345 72 for for IN cord-261417-4pf5nsw2 345 73 control control NN cord-261417-4pf5nsw2 345 74 of of IN cord-261417-4pf5nsw2 345 75 host host NN cord-261417-4pf5nsw2 345 76 and and CC cord-261417-4pf5nsw2 345 77 viral viral JJ cord-261417-4pf5nsw2 345 78 gene gene NN cord-261417-4pf5nsw2 345 79 expression expression NN cord-261417-4pf5nsw2 345 80 Characterization characterization NN cord-261417-4pf5nsw2 345 81 of of IN cord-261417-4pf5nsw2 345 82 a a DT cord-261417-4pf5nsw2 345 83 vaccinia vaccinia NN cord-261417-4pf5nsw2 345 84 virus virus NN cord-261417-4pf5nsw2 345 85 mutant mutant JJ cord-261417-4pf5nsw2 345 86 with with IN cord-261417-4pf5nsw2 345 87 a a DT cord-261417-4pf5nsw2 345 88 deletion deletion NN cord-261417-4pf5nsw2 345 89 of of IN cord-261417-4pf5nsw2 345 90 the the DT cord-261417-4pf5nsw2 345 91 D10R d10r NN cord-261417-4pf5nsw2 345 92 gene gene NN cord-261417-4pf5nsw2 345 93 encoding encode VBG cord-261417-4pf5nsw2 345 94 a a DT cord-261417-4pf5nsw2 345 95 putative putative JJ cord-261417-4pf5nsw2 345 96 negative negative JJ cord-261417-4pf5nsw2 345 97 regulator regulator NN cord-261417-4pf5nsw2 345 98 of of IN cord-261417-4pf5nsw2 345 99 gene gene NN cord-261417-4pf5nsw2 345 100 expression expression NN cord-261417-4pf5nsw2 345 101 Lytic lytic JJ cord-261417-4pf5nsw2 345 102 KSHV KSHV NNP cord-261417-4pf5nsw2 345 103 infection infection NN cord-261417-4pf5nsw2 345 104 inhibits inhibit VBZ cord-261417-4pf5nsw2 345 105 host host NN cord-261417-4pf5nsw2 345 106 gene gene NN cord-261417-4pf5nsw2 345 107 expression expression NN cord-261417-4pf5nsw2 345 108 by by IN cord-261417-4pf5nsw2 345 109 accelerating accelerate VBG cord-261417-4pf5nsw2 345 110 global global JJ cord-261417-4pf5nsw2 345 111 mRNA mrna NN cord-261417-4pf5nsw2 345 112 turnover turnover NN cord-261417-4pf5nsw2 345 113 Viral viral JJ cord-261417-4pf5nsw2 345 114 nucleases nuclease NNS cord-261417-4pf5nsw2 345 115 induce induce VBP cord-261417-4pf5nsw2 345 116 an an DT cord-261417-4pf5nsw2 345 117 mRNA mRNA NNP cord-261417-4pf5nsw2 345 118 degradation degradation NN cord-261417-4pf5nsw2 345 119 - - HYPH cord-261417-4pf5nsw2 345 120 transcription transcription NN cord-261417-4pf5nsw2 345 121 feedback feedback NN cord-261417-4pf5nsw2 345 122 loop loop NN cord-261417-4pf5nsw2 345 123 in in IN cord-261417-4pf5nsw2 345 124 mammalian mammalian JJ cord-261417-4pf5nsw2 345 125 cells cell NNS cord-261417-4pf5nsw2 345 126 Selective selective JJ cord-261417-4pf5nsw2 345 127 degradation degradation NN cord-261417-4pf5nsw2 345 128 of of IN cord-261417-4pf5nsw2 345 129 host host NN cord-261417-4pf5nsw2 345 130 RNA RNA NNP cord-261417-4pf5nsw2 345 131 polymerase polymerase NN cord-261417-4pf5nsw2 345 132 II II NNP cord-261417-4pf5nsw2 345 133 transcripts transcript NNS cord-261417-4pf5nsw2 345 134 by by IN cord-261417-4pf5nsw2 345 135 influenza influenza NN cord-261417-4pf5nsw2 345 136 A a DT cord-261417-4pf5nsw2 345 137 virus virus NN cord-261417-4pf5nsw2 346 1 PA PA NNP cord-261417-4pf5nsw2 346 2 - - HYPH cord-261417-4pf5nsw2 346 3 X X NNP cord-261417-4pf5nsw2 346 4 host host NN cord-261417-4pf5nsw2 346 5 shutoff shutoff NN cord-261417-4pf5nsw2 346 6 protein protein NN cord-261417-4pf5nsw2 347 1 An an DT cord-261417-4pf5nsw2 347 2 overlapping overlap VBG cord-261417-4pf5nsw2 347 3 protein protein NN cord-261417-4pf5nsw2 347 4 - - HYPH cord-261417-4pf5nsw2 347 5 coding code VBG cord-261417-4pf5nsw2 347 6 region region NN cord-261417-4pf5nsw2 347 7 in in IN cord-261417-4pf5nsw2 347 8 influenza influenza NN cord-261417-4pf5nsw2 347 9 A a DT cord-261417-4pf5nsw2 347 10 virus virus NN cord-261417-4pf5nsw2 347 11 segment segment NN cord-261417-4pf5nsw2 347 12 3 3 CD cord-261417-4pf5nsw2 347 13 modulates modulate VBZ cord-261417-4pf5nsw2 347 14 the the DT cord-261417-4pf5nsw2 347 15 host host NN cord-261417-4pf5nsw2 347 16 response response NN cord-261417-4pf5nsw2 347 17 Ribosomal Ribosomal NNP cord-261417-4pf5nsw2 347 18 frameshifting frameshifte VBG cord-261417-4pf5nsw2 347 19 used use VBN cord-261417-4pf5nsw2 347 20 in in IN cord-261417-4pf5nsw2 347 21 influenza influenza NN cord-261417-4pf5nsw2 347 22 A a DT cord-261417-4pf5nsw2 347 23 virus virus NN cord-261417-4pf5nsw2 347 24 expression expression NN cord-261417-4pf5nsw2 347 25 occurs occur VBZ cord-261417-4pf5nsw2 347 26 within within IN cord-261417-4pf5nsw2 347 27 the the DT cord-261417-4pf5nsw2 347 28 sequence sequence NN cord-261417-4pf5nsw2 347 29 UCC_UUU_CGU UCC_UUU_CGU NNP cord-261417-4pf5nsw2 347 30 and and CC cord-261417-4pf5nsw2 347 31 is be VBZ cord-261417-4pf5nsw2 347 32 in in IN cord-261417-4pf5nsw2 347 33 the the DT cord-261417-4pf5nsw2 347 34 +1 +1 HYPH cord-261417-4pf5nsw2 347 35 direction direction NN cord-261417-4pf5nsw2 347 36 Evolutionary evolutionary JJ cord-261417-4pf5nsw2 347 37 conservation conservation NN cord-261417-4pf5nsw2 347 38 of of IN cord-261417-4pf5nsw2 347 39 the the DT cord-261417-4pf5nsw2 347 40 PA PA NNP cord-261417-4pf5nsw2 347 41 - - HYPH cord-261417-4pf5nsw2 347 42 X X NNP cord-261417-4pf5nsw2 347 43 open open JJ cord-261417-4pf5nsw2 347 44 reading reading NN cord-261417-4pf5nsw2 347 45 frame frame NN cord-261417-4pf5nsw2 347 46 in in IN cord-261417-4pf5nsw2 347 47 segment segment NN cord-261417-4pf5nsw2 347 48 3 3 CD cord-261417-4pf5nsw2 347 49 of of IN cord-261417-4pf5nsw2 347 50 influenza influenza NN cord-261417-4pf5nsw2 347 51 A a DT cord-261417-4pf5nsw2 347 52 virus virus NN cord-261417-4pf5nsw2 347 53 Host host NN cord-261417-4pf5nsw2 347 54 shutoff shutoff NN cord-261417-4pf5nsw2 347 55 is be VBZ cord-261417-4pf5nsw2 347 56 a a DT cord-261417-4pf5nsw2 347 57 conserved conserved JJ cord-261417-4pf5nsw2 347 58 phenotype phenotype NN cord-261417-4pf5nsw2 347 59 of of IN cord-261417-4pf5nsw2 347 60 γ γ NN cord-261417-4pf5nsw2 347 61 herpesvirus herpesvirus NN cord-261417-4pf5nsw2 347 62 infection infection NN cord-261417-4pf5nsw2 347 63 and and CC cord-261417-4pf5nsw2 347 64 is be VBZ cord-261417-4pf5nsw2 347 65 orchestrated orchestrate VBN cord-261417-4pf5nsw2 347 66 exclusively exclusively RB cord-261417-4pf5nsw2 347 67 from from IN cord-261417-4pf5nsw2 347 68 the the DT cord-261417-4pf5nsw2 347 69 cytoplasm cytoplasm JJ cord-261417-4pf5nsw2 347 70 Crystal Crystal NNP cord-261417-4pf5nsw2 347 71 structure structure NN cord-261417-4pf5nsw2 347 72 of of IN cord-261417-4pf5nsw2 347 73 a a DT cord-261417-4pf5nsw2 347 74 KSHV KSHV NNP cord-261417-4pf5nsw2 347 75 - - HYPH cord-261417-4pf5nsw2 347 76 SOX SOX NNP cord-261417-4pf5nsw2 347 77 - - HYPH cord-261417-4pf5nsw2 347 78 DNA dna NN cord-261417-4pf5nsw2 347 79 complex complex NN cord-261417-4pf5nsw2 347 80 : : : cord-261417-4pf5nsw2 347 81 Insights insight NNS cord-261417-4pf5nsw2 347 82 into into IN cord-261417-4pf5nsw2 347 83 the the DT cord-261417-4pf5nsw2 347 84 molecular molecular JJ cord-261417-4pf5nsw2 347 85 mechanisms mechanism NNS cord-261417-4pf5nsw2 347 86 underlying underlie VBG cord-261417-4pf5nsw2 347 87 DNase DNase NNP cord-261417-4pf5nsw2 347 88 activity activity NN cord-261417-4pf5nsw2 347 89 and and CC cord-261417-4pf5nsw2 347 90 host host NN cord-261417-4pf5nsw2 347 91 shutoff shutoff NN cord-261417-4pf5nsw2 348 1 Coordinated coordinated JJ cord-261417-4pf5nsw2 348 2 destruction destruction NN cord-261417-4pf5nsw2 348 3 of of IN cord-261417-4pf5nsw2 348 4 cellular cellular JJ cord-261417-4pf5nsw2 348 5 messages message NNS cord-261417-4pf5nsw2 348 6 in in IN cord-261417-4pf5nsw2 348 7 translation translation NN cord-261417-4pf5nsw2 348 8 complexes complex NNS cord-261417-4pf5nsw2 348 9 by by IN cord-261417-4pf5nsw2 348 10 the the DT cord-261417-4pf5nsw2 348 11 γ γ NNP cord-261417-4pf5nsw2 348 12 herpesvirus herpesvirus NNP cord-261417-4pf5nsw2 348 13 host host NN cord-261417-4pf5nsw2 348 14 shutoff shutoff NN cord-261417-4pf5nsw2 348 15 factor factor NN cord-261417-4pf5nsw2 348 16 and and CC cord-261417-4pf5nsw2 348 17 the the DT cord-261417-4pf5nsw2 348 18 mammalian mammalian JJ cord-261417-4pf5nsw2 348 19 exonuclease exonuclease NN cord-261417-4pf5nsw2 349 1 XRN1 XRN1 NNP cord-261417-4pf5nsw2 349 2 A a DT cord-261417-4pf5nsw2 349 3 common common JJ cord-261417-4pf5nsw2 349 4 strategy strategy NN cord-261417-4pf5nsw2 349 5 for for IN cord-261417-4pf5nsw2 349 6 host host NN cord-261417-4pf5nsw2 349 7 RNA RNA NNP cord-261417-4pf5nsw2 349 8 degradation degradation NN cord-261417-4pf5nsw2 349 9 by by IN cord-261417-4pf5nsw2 349 10 divergent divergent JJ cord-261417-4pf5nsw2 349 11 viruses virus NNS cord-261417-4pf5nsw2 350 1 The the DT cord-261417-4pf5nsw2 350 2 novel novel JJ cord-261417-4pf5nsw2 350 3 influenza influenza NN cord-261417-4pf5nsw2 350 4 a a DT cord-261417-4pf5nsw2 350 5 virus virus NN cord-261417-4pf5nsw2 351 1 protein protein NNP cord-261417-4pf5nsw2 351 2 PA PA NNP cord-261417-4pf5nsw2 351 3 - - HYPH cord-261417-4pf5nsw2 351 4 X X NNP cord-261417-4pf5nsw2 351 5 and and CC cord-261417-4pf5nsw2 351 6 its -PRON- PRP$ cord-261417-4pf5nsw2 351 7 naturally naturally RB cord-261417-4pf5nsw2 351 8 deleted delete VBN cord-261417-4pf5nsw2 351 9 variant variant NN cord-261417-4pf5nsw2 351 10 show show VBP cord-261417-4pf5nsw2 351 11 different different JJ cord-261417-4pf5nsw2 351 12 enzymatic enzymatic JJ cord-261417-4pf5nsw2 351 13 properties property NNS cord-261417-4pf5nsw2 351 14 in in IN cord-261417-4pf5nsw2 351 15 comparison comparison NN cord-261417-4pf5nsw2 351 16 to to IN cord-261417-4pf5nsw2 351 17 the the DT cord-261417-4pf5nsw2 351 18 viral viral JJ cord-261417-4pf5nsw2 351 19 endonuclease endonuclease NN cord-261417-4pf5nsw2 352 1 PA PA NNP cord-261417-4pf5nsw2 352 2 We -PRON- PRP cord-261417-4pf5nsw2 352 3 thank thank VBP cord-261417-4pf5nsw2 352 4 Michael Michael NNP cord-261417-4pf5nsw2 352 5 Bellecourt Bellecourt NNP cord-261417-4pf5nsw2 352 6 , , , cord-261417-4pf5nsw2 352 7 Tatiana Tatiana NNP cord-261417-4pf5nsw2 352 8 Mishanina Mishanina NNP cord-261417-4pf5nsw2 352 9 and and CC cord-261417-4pf5nsw2 352 10 Indroneil Indroneil NNP cord-261417-4pf5nsw2 352 11 Ghosh Ghosh NNP cord-261417-4pf5nsw2 352 12 for for IN cord-261417-4pf5nsw2 352 13 helpful helpful JJ cord-261417-4pf5nsw2 352 14 comments comment NNS cord-261417-4pf5nsw2 352 15 on on IN cord-261417-4pf5nsw2 352 16 the the DT cord-261417-4pf5nsw2 352 17 manuscript manuscript NN cord-261417-4pf5nsw2 352 18 . . . cord-261417-4pf5nsw2 353 1 This this DT cord-261417-4pf5nsw2 353 2 research research NN cord-261417-4pf5nsw2 353 3 was be VBD cord-261417-4pf5nsw2 353 4 partially partially RB cord-261417-4pf5nsw2 353 5 supported support VBN cord-261417-4pf5nsw2 353 6 by by IN cord-261417-4pf5nsw2 353 7 NIH NIH NNP cord-261417-4pf5nsw2 353 8 grant grant NN cord-261417-4pf5nsw2 353 9 GM38660.Author GM38660.Author NNP cord-261417-4pf5nsw2 353 10 Contributions Contributions NNPS cord-261417-4pf5nsw2 353 11 : : : cord-261417-4pf5nsw2 353 12 All all DT cord-261417-4pf5nsw2 353 13 authors author NNS cord-261417-4pf5nsw2 353 14 wrote write VBD cord-261417-4pf5nsw2 353 15 , , , cord-261417-4pf5nsw2 353 16 read read VBD cord-261417-4pf5nsw2 353 17 , , , cord-261417-4pf5nsw2 353 18 and and CC cord-261417-4pf5nsw2 353 19 approved approve VBD cord-261417-4pf5nsw2 353 20 the the DT cord-261417-4pf5nsw2 353 21 final final JJ cord-261417-4pf5nsw2 353 22 manuscript manuscript NN cord-261417-4pf5nsw2 353 23 . . . cord-261417-4pf5nsw2 354 1 The the DT cord-261417-4pf5nsw2 354 2 authors author NNS cord-261417-4pf5nsw2 354 3 declare declare VBP cord-261417-4pf5nsw2 354 4 no no DT cord-261417-4pf5nsw2 354 5 conflict conflict NN cord-261417-4pf5nsw2 354 6 of of IN cord-261417-4pf5nsw2 354 7 interest interest NN cord-261417-4pf5nsw2 354 8 . . .