id	sid	tid	token	lemma	pos
cord-012418-6ralcn8p	1	1	key	key	JJ
cord-012418-6ralcn8p	1	2	:	:	:
cord-012418-6ralcn8p	1	3	cord-012418	cord-012418	NNP
cord-012418-6ralcn8p	1	4	-	-	HYPH
cord-012418-6ralcn8p	1	5	6ralcn8p	6ralcn8p	CD
cord-012418-6ralcn8p	1	6	authors	author	NNS
cord-012418-6ralcn8p	1	7	:	:	:
cord-012418-6ralcn8p	1	8	Schwanke	Schwanke	NNP
cord-012418-6ralcn8p	1	9	,	,	,
cord-012418-6ralcn8p	1	10	Hella	hella	UH
cord-012418-6ralcn8p	1	11	;	;	:
cord-012418-6ralcn8p	1	12	Stempel	Stempel	NNP
cord-012418-6ralcn8p	1	13	,	,	,
cord-012418-6ralcn8p	1	14	Markus	Markus	NNP
cord-012418-6ralcn8p	1	15	;	;	:
cord-012418-6ralcn8p	1	16	Brinkmann	Brinkmann	NNP
cord-012418-6ralcn8p	1	17	,	,	,
cord-012418-6ralcn8p	1	18	Melanie	Melanie	NNP
cord-012418-6ralcn8p	1	19	M.	M.	NNP
cord-012418-6ralcn8p	2	1	title	title	NN
cord-012418-6ralcn8p	2	2	:	:	:
cord-012418-6ralcn8p	3	1	Of	of	IN
cord-012418-6ralcn8p	3	2	Keeping	keep	VBG
cord-012418-6ralcn8p	3	3	and	and	CC
cord-012418-6ralcn8p	3	4	Tipping	tip	VBG
cord-012418-6ralcn8p	3	5	the	the	DT
cord-012418-6ralcn8p	3	6	Balance	Balance	NNP
cord-012418-6ralcn8p	3	7	:	:	:
cord-012418-6ralcn8p	3	8	Host	host	NN
cord-012418-6ralcn8p	3	9	Regulation	regulation	NN
cord-012418-6ralcn8p	3	10	and	and	CC
cord-012418-6ralcn8p	3	11	Viral	Viral	NNP
cord-012418-6ralcn8p	3	12	Modulation	Modulation	NNP
cord-012418-6ralcn8p	3	13	of	of	IN
cord-012418-6ralcn8p	4	1	IRF3-Dependent	IRF3-Dependent	NNP
cord-012418-6ralcn8p	4	2	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	4	3	Expression	Expression	NNP
cord-012418-6ralcn8p	4	4	date	date	NN
cord-012418-6ralcn8p	5	1	:	:	:
cord-012418-6ralcn8p	5	2	2020	2020	CD
cord-012418-6ralcn8p	5	3	-	-	HYPH
cord-012418-6ralcn8p	5	4	07	07	CD
cord-012418-6ralcn8p	5	5	-	-	HYPH
cord-012418-6ralcn8p	5	6	07	07	CD
cord-012418-6ralcn8p	5	7	journal	journal	NN
cord-012418-6ralcn8p	5	8	:	:	:
cord-012418-6ralcn8p	6	1	Viruses	virus	NNS
cord-012418-6ralcn8p	6	2	DOI	DOI	NNP
cord-012418-6ralcn8p	6	3	:	:	:
cord-012418-6ralcn8p	7	1	10.3390/	10.3390/	CD
cord-012418-6ralcn8p	8	1	v12070733	v12070733	NNP
cord-012418-6ralcn8p	8	2	sha	sha	NNP
cord-012418-6ralcn8p	8	3	:	:	:
cord-012418-6ralcn8p	8	4	a88229c823a05bcae7b40f6e3bce55b0b411d65e	a88229c823a05bcae7b40f6e3bce55b0b411d65e	NNP
cord-012418-6ralcn8p	8	5	doc_id	doc_id	NNP
cord-012418-6ralcn8p	8	6	:	:	:
cord-012418-6ralcn8p	8	7	12418	12418	CD
cord-012418-6ralcn8p	8	8	cord_uid	cord_uid	NNS
cord-012418-6ralcn8p	8	9	:	:	:
cord-012418-6ralcn8p	8	10	6ralcn8p	6ralcn8p	ADD
cord-012418-6ralcn8p	9	1	The	the	DT
cord-012418-6ralcn8p	9	2	type	type	NN
cord-012418-6ralcn8p	10	1	I	-PRON-	PRP
cord-012418-6ralcn8p	11	1	interferon	interferon	NNP
cord-012418-6ralcn8p	11	2	(	(	-LRB-
cord-012418-6ralcn8p	11	3	IFN	IFN	NNP
cord-012418-6ralcn8p	11	4	)	)	-RRB-
cord-012418-6ralcn8p	11	5	response	response	NN
cord-012418-6ralcn8p	11	6	is	be	VBZ
cord-012418-6ralcn8p	11	7	a	a	DT
cord-012418-6ralcn8p	11	8	principal	principal	JJ
cord-012418-6ralcn8p	11	9	component	component	NN
cord-012418-6ralcn8p	11	10	of	of	IN
cord-012418-6ralcn8p	11	11	our	-PRON-	PRP$
cord-012418-6ralcn8p	11	12	immune	immune	JJ
cord-012418-6ralcn8p	11	13	system	system	NN
cord-012418-6ralcn8p	11	14	that	that	WDT
cord-012418-6ralcn8p	11	15	allows	allow	VBZ
cord-012418-6ralcn8p	11	16	to	to	TO
cord-012418-6ralcn8p	11	17	counter	counter	VB
cord-012418-6ralcn8p	11	18	a	a	DT
cord-012418-6ralcn8p	11	19	viral	viral	JJ
cord-012418-6ralcn8p	11	20	attack	attack	NN
cord-012418-6ralcn8p	11	21	immediately	immediately	RB
cord-012418-6ralcn8p	11	22	upon	upon	IN
cord-012418-6ralcn8p	11	23	viral	viral	JJ
cord-012418-6ralcn8p	11	24	entry	entry	NN
cord-012418-6ralcn8p	11	25	into	into	IN
cord-012418-6ralcn8p	11	26	host	host	NN
cord-012418-6ralcn8p	11	27	cells	cell	NNS
cord-012418-6ralcn8p	11	28	.	.	.
cord-012418-6ralcn8p	12	1	Upon	upon	IN
cord-012418-6ralcn8p	12	2	engagement	engagement	NN
cord-012418-6ralcn8p	12	3	of	of	IN
cord-012418-6ralcn8p	12	4	aberrantly	aberrantly	RB
cord-012418-6ralcn8p	12	5	localised	localised	JJ
cord-012418-6ralcn8p	12	6	nucleic	nucleic	JJ
cord-012418-6ralcn8p	12	7	acids	acid	NNS
cord-012418-6ralcn8p	12	8	,	,	,
cord-012418-6ralcn8p	12	9	germline	germline	NN
cord-012418-6ralcn8p	12	10	-	-	HYPH
cord-012418-6ralcn8p	12	11	encoded	encode	VBN
cord-012418-6ralcn8p	12	12	pattern	pattern	NN
cord-012418-6ralcn8p	12	13	recognition	recognition	NN
cord-012418-6ralcn8p	12	14	receptors	receptor	NNS
cord-012418-6ralcn8p	12	15	convey	convey	VBP
cord-012418-6ralcn8p	12	16	their	-PRON-	PRP$
cord-012418-6ralcn8p	12	17	find	find	NN
cord-012418-6ralcn8p	12	18	via	via	IN
cord-012418-6ralcn8p	12	19	a	a	DT
cord-012418-6ralcn8p	12	20	signalling	signal	VBG
cord-012418-6ralcn8p	12	21	cascade	cascade	NN
cord-012418-6ralcn8p	12	22	to	to	IN
cord-012418-6ralcn8p	12	23	prompt	prompt	JJ
cord-012418-6ralcn8p	12	24	kinase	kinase	NN
cord-012418-6ralcn8p	12	25	-	-	HYPH
cord-012418-6ralcn8p	12	26	mediated	mediate	VBN
cord-012418-6ralcn8p	12	27	activation	activation	NN
cord-012418-6ralcn8p	12	28	of	of	IN
cord-012418-6ralcn8p	12	29	a	a	DT
cord-012418-6ralcn8p	12	30	specific	specific	JJ
cord-012418-6ralcn8p	12	31	set	set	NN
cord-012418-6ralcn8p	12	32	of	of	IN
cord-012418-6ralcn8p	12	33	five	five	CD
cord-012418-6ralcn8p	12	34	transcription	transcription	NN
cord-012418-6ralcn8p	12	35	factors	factor	NNS
cord-012418-6ralcn8p	12	36	.	.	.
cord-012418-6ralcn8p	13	1	Within	within	IN
cord-012418-6ralcn8p	13	2	the	the	DT
cord-012418-6ralcn8p	13	3	nucleus	nucleus	NN
cord-012418-6ralcn8p	13	4	,	,	,
cord-012418-6ralcn8p	13	5	the	the	DT
cord-012418-6ralcn8p	13	6	coordinated	coordinated	JJ
cord-012418-6ralcn8p	13	7	interaction	interaction	NN
cord-012418-6ralcn8p	13	8	of	of	IN
cord-012418-6ralcn8p	13	9	these	these	DT
cord-012418-6ralcn8p	13	10	dimeric	dimeric	JJ
cord-012418-6ralcn8p	13	11	transcription	transcription	NN
cord-012418-6ralcn8p	13	12	factors	factor	NNS
cord-012418-6ralcn8p	13	13	with	with	IN
cord-012418-6ralcn8p	13	14	coactivators	coactivator	NNS
cord-012418-6ralcn8p	13	15	and	and	CC
cord-012418-6ralcn8p	13	16	the	the	DT
cord-012418-6ralcn8p	13	17	basal	basal	NN
cord-012418-6ralcn8p	13	18	RNA	RNA	NNP
cord-012418-6ralcn8p	13	19	transcription	transcription	NN
cord-012418-6ralcn8p	13	20	machinery	machinery	NN
cord-012418-6ralcn8p	13	21	is	be	VBZ
cord-012418-6ralcn8p	13	22	required	require	VBN
cord-012418-6ralcn8p	13	23	to	to	TO
cord-012418-6ralcn8p	13	24	access	access	VB
cord-012418-6ralcn8p	13	25	the	the	DT
cord-012418-6ralcn8p	13	26	gene	gene	NN
cord-012418-6ralcn8p	13	27	encoding	encode	VBG
cord-012418-6ralcn8p	13	28	the	the	DT
cord-012418-6ralcn8p	13	29	type	type	NN
cord-012418-6ralcn8p	14	1	I	-PRON-	PRP
cord-012418-6ralcn8p	14	2	IFN	IFN	NNP
cord-012418-6ralcn8p	14	3	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	14	4	(	(	-LRB-
cord-012418-6ralcn8p	14	5	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	14	6	)	)	-RRB-
cord-012418-6ralcn8p	14	7	.	.	.
cord-012418-6ralcn8p	15	1	Virus	virus	NN
cord-012418-6ralcn8p	15	2	-	-	HYPH
cord-012418-6ralcn8p	15	3	induced	induce	VBN
cord-012418-6ralcn8p	15	4	release	release	NN
cord-012418-6ralcn8p	15	5	of	of	IN
cord-012418-6ralcn8p	15	6	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	15	7	then	then	RB
cord-012418-6ralcn8p	15	8	induces	induce	VBZ
cord-012418-6ralcn8p	15	9	the	the	DT
cord-012418-6ralcn8p	15	10	antiviral	antiviral	JJ
cord-012418-6ralcn8p	15	11	state	state	NN
cord-012418-6ralcn8p	15	12	of	of	IN
cord-012418-6ralcn8p	15	13	the	the	DT
cord-012418-6ralcn8p	15	14	system	system	NN
cord-012418-6ralcn8p	15	15	and	and	CC
cord-012418-6ralcn8p	15	16	mediates	mediate	VBZ
cord-012418-6ralcn8p	15	17	further	further	JJ
cord-012418-6ralcn8p	15	18	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	15	19	for	for	IN
cord-012418-6ralcn8p	15	20	defence	defence	NN
cord-012418-6ralcn8p	15	21	.	.	.
cord-012418-6ralcn8p	16	1	Due	due	IN
cord-012418-6ralcn8p	16	2	to	to	IN
cord-012418-6ralcn8p	16	3	its	-PRON-	PRP$
cord-012418-6ralcn8p	16	4	key	key	JJ
cord-012418-6ralcn8p	16	5	role	role	NN
cord-012418-6ralcn8p	16	6	during	during	IN
cord-012418-6ralcn8p	16	7	the	the	DT
cord-012418-6ralcn8p	16	8	induction	induction	NN
cord-012418-6ralcn8p	16	9	of	of	IN
cord-012418-6ralcn8p	16	10	the	the	DT
cord-012418-6ralcn8p	16	11	initial	initial	JJ
cord-012418-6ralcn8p	16	12	IFN	IFN	NNP
cord-012418-6ralcn8p	16	13	response	response	NN
cord-012418-6ralcn8p	16	14	,	,	,
cord-012418-6ralcn8p	16	15	the	the	DT
cord-012418-6ralcn8p	16	16	activity	activity	NN
cord-012418-6ralcn8p	16	17	of	of	IN
cord-012418-6ralcn8p	16	18	the	the	DT
cord-012418-6ralcn8p	16	19	transcription	transcription	NN
cord-012418-6ralcn8p	16	20	factor	factor	NN
cord-012418-6ralcn8p	16	21	interferon	interferon	NN
cord-012418-6ralcn8p	16	22	regulatory	regulatory	JJ
cord-012418-6ralcn8p	16	23	factor	factor	NN
cord-012418-6ralcn8p	16	24	3	3	CD
cord-012418-6ralcn8p	17	1	(	(	-LRB-
cord-012418-6ralcn8p	17	2	IRF3	IRF3	NNP
cord-012418-6ralcn8p	17	3	)	)	-RRB-
cord-012418-6ralcn8p	17	4	is	be	VBZ
cord-012418-6ralcn8p	17	5	tightly	tightly	RB
cord-012418-6ralcn8p	17	6	regulated	regulate	VBN
cord-012418-6ralcn8p	17	7	by	by	IN
cord-012418-6ralcn8p	17	8	the	the	DT
cord-012418-6ralcn8p	17	9	host	host	NN
cord-012418-6ralcn8p	17	10	and	and	CC
cord-012418-6ralcn8p	17	11	fiercely	fiercely	RB
cord-012418-6ralcn8p	17	12	targeted	target	VBN
cord-012418-6ralcn8p	17	13	by	by	IN
cord-012418-6ralcn8p	17	14	viral	viral	JJ
cord-012418-6ralcn8p	17	15	proteins	protein	NNS
cord-012418-6ralcn8p	17	16	at	at	IN
cord-012418-6ralcn8p	17	17	all	all	DT
cord-012418-6ralcn8p	17	18	conceivable	conceivable	JJ
cord-012418-6ralcn8p	17	19	levels	level	NNS
cord-012418-6ralcn8p	17	20	.	.	.
cord-012418-6ralcn8p	18	1	In	in	IN
cord-012418-6ralcn8p	18	2	this	this	DT
cord-012418-6ralcn8p	18	3	review	review	NN
cord-012418-6ralcn8p	18	4	,	,	,
cord-012418-6ralcn8p	18	5	we	-PRON-	PRP
cord-012418-6ralcn8p	18	6	will	will	MD
cord-012418-6ralcn8p	18	7	revisit	revisit	VB
cord-012418-6ralcn8p	18	8	the	the	DT
cord-012418-6ralcn8p	18	9	steps	step	NNS
cord-012418-6ralcn8p	18	10	enabling	enable	VBG
cord-012418-6ralcn8p	18	11	the	the	DT
cord-012418-6ralcn8p	18	12	trans	trans	NNP
cord-012418-6ralcn8p	18	13	-	-	HYPH
cord-012418-6ralcn8p	18	14	activating	activate	VBG
cord-012418-6ralcn8p	18	15	potential	potential	NN
cord-012418-6ralcn8p	18	16	of	of	IN
cord-012418-6ralcn8p	18	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	18	18	after	after	IN
cord-012418-6ralcn8p	18	19	its	-PRON-	PRP$
cord-012418-6ralcn8p	18	20	activation	activation	NN
cord-012418-6ralcn8p	18	21	and	and	CC
cord-012418-6ralcn8p	18	22	the	the	DT
cord-012418-6ralcn8p	18	23	subsequent	subsequent	JJ
cord-012418-6ralcn8p	18	24	assembly	assembly	NN
cord-012418-6ralcn8p	18	25	of	of	IN
cord-012418-6ralcn8p	18	26	the	the	DT
cord-012418-6ralcn8p	18	27	multi	multi	JJ
cord-012418-6ralcn8p	18	28	-	-	JJ
cord-012418-6ralcn8p	18	29	protein	protein	JJ
cord-012418-6ralcn8p	18	30	complex	complex	NN
cord-012418-6ralcn8p	18	31	at	at	IN
cord-012418-6ralcn8p	18	32	the	the	DT
cord-012418-6ralcn8p	18	33	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	18	34	enhancer	enhancer	NN
cord-012418-6ralcn8p	18	35	that	that	WDT
cord-012418-6ralcn8p	18	36	controls	control	VBZ
cord-012418-6ralcn8p	18	37	gene	gene	NN
cord-012418-6ralcn8p	18	38	expression	expression	NN
cord-012418-6ralcn8p	18	39	.	.	.
cord-012418-6ralcn8p	19	1	Further	further	RB
cord-012418-6ralcn8p	19	2	,	,	,
cord-012418-6ralcn8p	19	3	we	-PRON-	PRP
cord-012418-6ralcn8p	19	4	will	will	MD
cord-012418-6ralcn8p	19	5	inspect	inspect	VB
cord-012418-6ralcn8p	19	6	the	the	DT
cord-012418-6ralcn8p	19	7	regulatory	regulatory	JJ
cord-012418-6ralcn8p	19	8	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	19	9	of	of	IN
cord-012418-6ralcn8p	19	10	these	these	DT
cord-012418-6ralcn8p	19	11	steps	step	NNS
cord-012418-6ralcn8p	19	12	imposed	impose	VBN
cord-012418-6ralcn8p	19	13	by	by	IN
cord-012418-6ralcn8p	19	14	the	the	DT
cord-012418-6ralcn8p	19	15	host	host	NN
cord-012418-6ralcn8p	19	16	cell	cell	NN
cord-012418-6ralcn8p	19	17	and	and	CC
cord-012418-6ralcn8p	19	18	present	present	VB
cord-012418-6ralcn8p	19	19	the	the	DT
cord-012418-6ralcn8p	19	20	manifold	manifold	JJ
cord-012418-6ralcn8p	19	21	strategies	strategy	NNS
cord-012418-6ralcn8p	19	22	viruses	virus	NNS
cord-012418-6ralcn8p	19	23	have	have	VBP
cord-012418-6ralcn8p	19	24	evolved	evolve	VBN
cord-012418-6ralcn8p	19	25	to	to	TO
cord-012418-6ralcn8p	19	26	intervene	intervene	VB
cord-012418-6ralcn8p	19	27	with	with	IN
cord-012418-6ralcn8p	19	28	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	19	29	transcription	transcription	NN
cord-012418-6ralcn8p	19	30	downstream	downstream	RB
cord-012418-6ralcn8p	19	31	of	of	IN
cord-012418-6ralcn8p	19	32	IRF3	IRF3	NNP
cord-012418-6ralcn8p	19	33	activation	activation	NN
cord-012418-6ralcn8p	19	34	in	in	IN
cord-012418-6ralcn8p	19	35	order	order	NN
cord-012418-6ralcn8p	19	36	to	to	TO
cord-012418-6ralcn8p	19	37	secure	secure	VB
cord-012418-6ralcn8p	19	38	establishment	establishment	NN
cord-012418-6ralcn8p	19	39	of	of	IN
cord-012418-6ralcn8p	19	40	a	a	DT
cord-012418-6ralcn8p	19	41	productive	productive	JJ
cord-012418-6ralcn8p	19	42	infection	infection	NN
cord-012418-6ralcn8p	19	43	.	.	.
cord-012418-6ralcn8p	20	1	The	the	DT
cord-012418-6ralcn8p	20	2	interferon	interferon	NN
cord-012418-6ralcn8p	20	3	(	(	-LRB-
cord-012418-6ralcn8p	20	4	IFN	IFN	NNP
cord-012418-6ralcn8p	20	5	)	)	-RRB-
cord-012418-6ralcn8p	20	6	system	system	NN
cord-012418-6ralcn8p	20	7	provides	provide	VBZ
cord-012418-6ralcn8p	20	8	mammalian	mammalian	JJ
cord-012418-6ralcn8p	20	9	cells	cell	NNS
cord-012418-6ralcn8p	20	10	with	with	IN
cord-012418-6ralcn8p	20	11	a	a	DT
cord-012418-6ralcn8p	20	12	potent	potent	JJ
cord-012418-6ralcn8p	20	13	framework	framework	NN
cord-012418-6ralcn8p	20	14	to	to	TO
cord-012418-6ralcn8p	20	15	fend	fend	VB
cord-012418-6ralcn8p	20	16	off	off	RP
cord-012418-6ralcn8p	20	17	intruding	intrude	VBG
cord-012418-6ralcn8p	20	18	pathogens	pathogen	NNS
cord-012418-6ralcn8p	20	19	.	.	.
cord-012418-6ralcn8p	21	1	Interferons	interferon	NNS
cord-012418-6ralcn8p	21	2	are	be	VBP
cord-012418-6ralcn8p	21	3	signalling	signal	VBG
cord-012418-6ralcn8p	21	4	molecules	molecule	NNS
cord-012418-6ralcn8p	21	5	first	first	RB
cord-012418-6ralcn8p	21	6	discovered	discover	VBD
cord-012418-6ralcn8p	21	7	more	more	JJR
cord-012418-6ralcn8p	21	8	than	than	IN
cord-012418-6ralcn8p	21	9	60	60	CD
cord-012418-6ralcn8p	21	10	years	year	NNS
cord-012418-6ralcn8p	21	11	ago	ago	RB
cord-012418-6ralcn8p	21	12	,	,	,
cord-012418-6ralcn8p	21	13	when	when	WRB
cord-012418-6ralcn8p	21	14	virus	virus	NN
cord-012418-6ralcn8p	21	15	-	-	HYPH
cord-012418-6ralcn8p	21	16	infected	infect	VBN
cord-012418-6ralcn8p	21	17	cells	cell	NNS
cord-012418-6ralcn8p	21	18	were	be	VBD
cord-012418-6ralcn8p	21	19	found	find	VBN
cord-012418-6ralcn8p	21	20	to	to	TO
cord-012418-6ralcn8p	21	21	release	release	VB
cord-012418-6ralcn8p	21	22	soluble	soluble	JJ
cord-012418-6ralcn8p	21	23	compounds	compound	NNS
cord-012418-6ralcn8p	21	24	that	that	WDT
cord-012418-6ralcn8p	21	25	could	could	MD
cord-012418-6ralcn8p	21	26	interfere	interfere	VB
cord-012418-6ralcn8p	21	27	with	with	IN
cord-012418-6ralcn8p	21	28	establishment	establishment	NN
cord-012418-6ralcn8p	21	29	of	of	IN
cord-012418-6ralcn8p	21	30	virus	virus	NN
cord-012418-6ralcn8p	21	31	infection	infection	NN
cord-012418-6ralcn8p	21	32	[	[	-LRB-
cord-012418-6ralcn8p	21	33	1	1	CD
cord-012418-6ralcn8p	21	34	]	]	-RRB-
cord-012418-6ralcn8p	21	35	.	.	.
cord-012418-6ralcn8p	22	1	Since	since	IN
cord-012418-6ralcn8p	22	2	this	this	DT
cord-012418-6ralcn8p	22	3	initial	initial	JJ
cord-012418-6ralcn8p	22	4	discovery	discovery	NN
cord-012418-6ralcn8p	22	5	,	,	,
cord-012418-6ralcn8p	22	6	we	-PRON-	PRP
cord-012418-6ralcn8p	22	7	have	have	VBP
cord-012418-6ralcn8p	22	8	come	come	VBN
cord-012418-6ralcn8p	22	9	to	to	TO
cord-012418-6ralcn8p	22	10	understand	understand	VB
cord-012418-6ralcn8p	22	11	the	the	DT
cord-012418-6ralcn8p	22	12	pivotal	pivotal	JJ
cord-012418-6ralcn8p	22	13	role	role	NN
cord-012418-6ralcn8p	22	14	of	of	IN
cord-012418-6ralcn8p	22	15	interferon	interferon	NN
cord-012418-6ralcn8p	22	16	signalling	signal	VBG
cord-012418-6ralcn8p	22	17	for	for	IN
cord-012418-6ralcn8p	22	18	the	the	DT
cord-012418-6ralcn8p	22	19	immune	immune	JJ
cord-012418-6ralcn8p	22	20	response	response	NN
cord-012418-6ralcn8p	22	21	to	to	IN
cord-012418-6ralcn8p	22	22	invading	invade	VBG
cord-012418-6ralcn8p	22	23	pathogens	pathogen	NNS
cord-012418-6ralcn8p	22	24	,	,	,
cord-012418-6ralcn8p	22	25	from	from	IN
cord-012418-6ralcn8p	22	26	conveying	convey	VBG
cord-012418-6ralcn8p	22	27	the	the	DT
cord-012418-6ralcn8p	22	28	very	very	RB
cord-012418-6ralcn8p	22	29	first	first	JJ
cord-012418-6ralcn8p	22	30	notice	notice	NN
cord-012418-6ralcn8p	22	31	of	of	IN
cord-012418-6ralcn8p	22	32	intrusion	intrusion	NN
cord-012418-6ralcn8p	22	33	to	to	IN
cord-012418-6ralcn8p	22	34	eliciting	elicit	VBG
cord-012418-6ralcn8p	22	35	a	a	DT
cord-012418-6ralcn8p	22	36	well	well	RB
cord-012418-6ralcn8p	22	37	-	-	HYPH
cord-012418-6ralcn8p	22	38	tailored	tailor	VBN
cord-012418-6ralcn8p	22	39	immune	immune	JJ
cord-012418-6ralcn8p	22	40	reaction	reaction	NN
cord-012418-6ralcn8p	22	41	suited	suit	VBN
cord-012418-6ralcn8p	22	42	to	to	TO
cord-012418-6ralcn8p	22	43	thwart	thwart	VB
cord-012418-6ralcn8p	22	44	the	the	DT
cord-012418-6ralcn8p	22	45	infection	infection	NN
cord-012418-6ralcn8p	22	46	.	.	.
cord-012418-6ralcn8p	23	1	Today	today	NN
cord-012418-6ralcn8p	23	2	,	,	,
cord-012418-6ralcn8p	23	3	we	-PRON-	PRP
cord-012418-6ralcn8p	23	4	differentiate	differentiate	VBP
cord-012418-6ralcn8p	23	5	three	three	CD
cord-012418-6ralcn8p	23	6	classes	class	NNS
cord-012418-6ralcn8p	23	7	of	of	IN
cord-012418-6ralcn8p	23	8	interferons	interferon	NNS
cord-012418-6ralcn8p	23	9	based	base	VBN
cord-012418-6ralcn8p	23	10	on	on	IN
cord-012418-6ralcn8p	23	11	the	the	DT
cord-012418-6ralcn8p	23	12	receptor	receptor	NN
cord-012418-6ralcn8p	23	13	they	-PRON-	PRP
cord-012418-6ralcn8p	23	14	employ	employ	VBP
cord-012418-6ralcn8p	23	15	for	for	IN
cord-012418-6ralcn8p	23	16	signal	signal	NN
cord-012418-6ralcn8p	23	17	transduction	transduction	NN
cord-012418-6ralcn8p	23	18	.	.	.
cord-012418-6ralcn8p	24	1	More	More	JJR
cord-012418-6ralcn8p	24	2	than	than	IN
cord-012418-6ralcn8p	24	3	a	a	DT
cord-012418-6ralcn8p	24	4	dozen	dozen	NN
cord-012418-6ralcn8p	24	5	genes	gene	NNS
cord-012418-6ralcn8p	24	6	encoding	encode	VBG
cord-012418-6ralcn8p	24	7	IFNα	IFNα	NNP
cord-012418-6ralcn8p	24	8	subtypes	subtype	NNS
cord-012418-6ralcn8p	24	9	and	and	CC
cord-012418-6ralcn8p	24	10	a	a	DT
cord-012418-6ralcn8p	24	11	single	single	JJ
cord-012418-6ralcn8p	24	12	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	24	13	gene	gene	NN
cord-012418-6ralcn8p	24	14	give	give	VBP
cord-012418-6ralcn8p	24	15	rise	rise	NN
cord-012418-6ralcn8p	24	16	to	to	IN
cord-012418-6ralcn8p	24	17	the	the	DT
cord-012418-6ralcn8p	24	18	majority	majority	NN
cord-012418-6ralcn8p	24	19	of	of	IN
cord-012418-6ralcn8p	24	20	type	type	NN
cord-012418-6ralcn8p	24	21	I	-PRON-	PRP
cord-012418-6ralcn8p	24	22	IFNs	ifns	VBP
cord-012418-6ralcn8p	24	23	in	in	IN
cord-012418-6ralcn8p	24	24	humans	human	NNS
cord-012418-6ralcn8p	24	25	.	.	.
cord-012418-6ralcn8p	25	1	They	-PRON-	PRP
cord-012418-6ralcn8p	25	2	are	be	VBP
cord-012418-6ralcn8p	25	3	the	the	DT
cord-012418-6ralcn8p	25	4	first	first	JJ
cord-012418-6ralcn8p	25	5	messenger	messenger	NN
cord-012418-6ralcn8p	25	6	molecules	molecule	NNS
cord-012418-6ralcn8p	25	7	released	release	VBN
cord-012418-6ralcn8p	25	8	upon	upon	IN
cord-012418-6ralcn8p	25	9	detection	detection	NN
cord-012418-6ralcn8p	25	10	of	of	IN
cord-012418-6ralcn8p	25	11	a	a	DT
cord-012418-6ralcn8p	25	12	pathogen	pathogen	NN
cord-012418-6ralcn8p	25	13	by	by	IN
cord-012418-6ralcn8p	25	14	infected	infected	JJ
cord-012418-6ralcn8p	25	15	cells	cell	NNS
cord-012418-6ralcn8p	25	16	and	and	CC
cord-012418-6ralcn8p	25	17	by	by	IN
cord-012418-6ralcn8p	25	18	bystanders	bystander	NNS
cord-012418-6ralcn8p	25	19	to	to	TO
cord-012418-6ralcn8p	25	20	initiate	initiate	VB
cord-012418-6ralcn8p	25	21	the	the	DT
cord-012418-6ralcn8p	25	22	intrinsic	intrinsic	JJ
cord-012418-6ralcn8p	25	23	defence	defence	NN
cord-012418-6ralcn8p	25	24	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	25	25	and	and	CC
cord-012418-6ralcn8p	25	26	to	to	TO
cord-012418-6ralcn8p	25	27	further	further	RB
cord-012418-6ralcn8p	25	28	involve	involve	VB
cord-012418-6ralcn8p	25	29	dedicated	dedicated	JJ
cord-012418-6ralcn8p	25	30	cells	cell	NNS
cord-012418-6ralcn8p	25	31	of	of	IN
cord-012418-6ralcn8p	25	32	the	the	DT
cord-012418-6ralcn8p	25	33	immune	immune	JJ
cord-012418-6ralcn8p	25	34	system	system	NN
cord-012418-6ralcn8p	25	35	(	(	-LRB-
cord-012418-6ralcn8p	25	36	recently	recently	RB
cord-012418-6ralcn8p	25	37	reviewed	review	VBN
cord-012418-6ralcn8p	25	38	in	in	IN
cord-012418-6ralcn8p	25	39	[	[	-LRB-
cord-012418-6ralcn8p	25	40	2	2	CD
cord-012418-6ralcn8p	25	41	,	,	,
cord-012418-6ralcn8p	25	42	3	3	CD
cord-012418-6ralcn8p	25	43	]	]	-RRB-
cord-012418-6ralcn8p	25	44	)	)	-RRB-
cord-012418-6ralcn8p	25	45	.	.	.
cord-012418-6ralcn8p	26	1	IFNγ	IFNγ	NNS
cord-012418-6ralcn8p	26	2	,	,	,
cord-012418-6ralcn8p	26	3	the	the	DT
cord-012418-6ralcn8p	26	4	only	only	JJ
cord-012418-6ralcn8p	26	5	type	type	NN
cord-012418-6ralcn8p	26	6	II	II	NNP
cord-012418-6ralcn8p	26	7	IFN	IFN	NNP
cord-012418-6ralcn8p	26	8	,	,	,
cord-012418-6ralcn8p	26	9	presents	present	VBZ
cord-012418-6ralcn8p	26	10	In	in	IN
cord-012418-6ralcn8p	26	11	the	the	DT
cord-012418-6ralcn8p	26	12	latent	latent	JJ
cord-012418-6ralcn8p	26	13	state	state	NN
cord-012418-6ralcn8p	26	14	,	,	,
cord-012418-6ralcn8p	26	15	a	a	DT
cord-012418-6ralcn8p	26	16	part	part	NN
cord-012418-6ralcn8p	26	17	of	of	IN
cord-012418-6ralcn8p	26	18	the	the	DT
cord-012418-6ralcn8p	26	19	linker	linker	NN
cord-012418-6ralcn8p	26	20	and	and	CC
cord-012418-6ralcn8p	26	21	the	the	DT
cord-012418-6ralcn8p	26	22	most	most	JJS
cord-012418-6ralcn8p	26	23	C	c	NN
cord-012418-6ralcn8p	26	24	-	-	HYPH
cord-012418-6ralcn8p	26	25	terminal	terminal	NN
cord-012418-6ralcn8p	26	26	portion	portion	NN
cord-012418-6ralcn8p	26	27	form	form	NN
cord-012418-6ralcn8p	26	28	auto	auto	NN
cord-012418-6ralcn8p	26	29	-	-	HYPH
cord-012418-6ralcn8p	26	30	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	26	31	elements	element	NNS
cord-012418-6ralcn8p	26	32	(	(	-LRB-
cord-012418-6ralcn8p	26	33	AIEs	AIEs	NNP
cord-012418-6ralcn8p	26	34	)	)	-RRB-
cord-012418-6ralcn8p	26	35	.	.	.
cord-012418-6ralcn8p	27	1	Phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	27	2	of	of	IN
cord-012418-6ralcn8p	27	3	two	two	CD
cord-012418-6ralcn8p	27	4	serine	serine	JJ
cord-012418-6ralcn8p	27	5	-	-	HYPH
cord-012418-6ralcn8p	27	6	rich	rich	JJ
cord-012418-6ralcn8p	27	7	clusters	cluster	NNS
cord-012418-6ralcn8p	27	8	(	(	-LRB-
cord-012418-6ralcn8p	27	9	c1	c1	NNP
cord-012418-6ralcn8p	27	10	and	and	CC
cord-012418-6ralcn8p	27	11	c2	c2	NNP
cord-012418-6ralcn8p	27	12	)	)	-RRB-
cord-012418-6ralcn8p	27	13	induces	induce	VBZ
cord-012418-6ralcn8p	27	14	conformational	conformational	JJ
cord-012418-6ralcn8p	27	15	rearrangements	rearrangement	NNS
cord-012418-6ralcn8p	27	16	of	of	IN
cord-012418-6ralcn8p	27	17	the	the	DT
cord-012418-6ralcn8p	27	18	AIEs	aie	NNS
cord-012418-6ralcn8p	27	19	and	and	CC
cord-012418-6ralcn8p	27	20	frees	free	VBZ
cord-012418-6ralcn8p	27	21	the	the	DT
cord-012418-6ralcn8p	27	22	IAD	IAD	NNP
cord-012418-6ralcn8p	27	23	to	to	TO
cord-012418-6ralcn8p	27	24	participate	participate	VB
cord-012418-6ralcn8p	27	25	in	in	IN
cord-012418-6ralcn8p	27	26	protein	protein	NN
cord-012418-6ralcn8p	27	27	-	-	HYPH
cord-012418-6ralcn8p	27	28	protein	protein	NN
cord-012418-6ralcn8p	27	29	interactions	interaction	NNS
cord-012418-6ralcn8p	27	30	with	with	IN
cord-012418-6ralcn8p	27	31	coactivators	coactivator	NNS
cord-012418-6ralcn8p	27	32	and	and	CC
cord-012418-6ralcn8p	27	33	for	for	IN
cord-012418-6ralcn8p	27	34	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	27	35	via	via	IN
cord-012418-6ralcn8p	27	36	the	the	DT
cord-012418-6ralcn8p	27	37	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	27	38	pLxIS	plxis	NN
cord-012418-6ralcn8p	27	39	motif	motif	NN
cord-012418-6ralcn8p	27	40	(	(	-LRB-
cord-012418-6ralcn8p	27	41	p	p	NN
cord-012418-6ralcn8p	27	42	:	:	:
cord-012418-6ralcn8p	27	43	hydrophilic	hydrophilic	JJ
cord-012418-6ralcn8p	27	44	,	,	,
cord-012418-6ralcn8p	28	1	x	x	LS
cord-012418-6ralcn8p	28	2	:	:	:
cord-012418-6ralcn8p	28	3	any	any	DT
cord-012418-6ralcn8p	28	4	amino	amino	NN
cord-012418-6ralcn8p	28	5	acid	acid	NN
cord-012418-6ralcn8p	28	6	)	)	-RRB-
cord-012418-6ralcn8p	28	7	.	.	.
cord-012418-6ralcn8p	29	1	The	the	DT
cord-012418-6ralcn8p	29	2	protein	protein	NN
cord-012418-6ralcn8p	29	3	further	further	RB
cord-012418-6ralcn8p	29	4	contains	contain	VBZ
cord-012418-6ralcn8p	29	5	a	a	DT
cord-012418-6ralcn8p	29	6	nuclear	nuclear	JJ
cord-012418-6ralcn8p	29	7	localization	localization	NN
cord-012418-6ralcn8p	29	8	signal	signal	NN
cord-012418-6ralcn8p	29	9	(	(	-LRB-
cord-012418-6ralcn8p	29	10	NLS	NLS	NNP
cord-012418-6ralcn8p	29	11	)	)	-RRB-
cord-012418-6ralcn8p	29	12	and	and	CC
cord-012418-6ralcn8p	29	13	a	a	DT
cord-012418-6ralcn8p	29	14	nuclear	nuclear	JJ
cord-012418-6ralcn8p	29	15	exit	exit	NN
cord-012418-6ralcn8p	29	16	signal	signal	NN
cord-012418-6ralcn8p	29	17	(	(	-LRB-
cord-012418-6ralcn8p	29	18	NES	NES	NNP
cord-012418-6ralcn8p	29	19	)	)	-RRB-
cord-012418-6ralcn8p	29	20	that	that	WDT
cord-012418-6ralcn8p	29	21	enable	enable	VBP
cord-012418-6ralcn8p	29	22	constitutive	constitutive	JJ
cord-012418-6ralcn8p	29	23	shuttling	shuttling	NN
cord-012418-6ralcn8p	29	24	between	between	IN
cord-012418-6ralcn8p	29	25	the	the	DT
cord-012418-6ralcn8p	29	26	cytosol	cytosol	NN
cord-012418-6ralcn8p	29	27	and	and	CC
cord-012418-6ralcn8p	29	28	nucleus	nucleus	NN
cord-012418-6ralcn8p	29	29	.	.	.
cord-012418-6ralcn8p	30	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	30	2	and	and	CC
cord-012418-6ralcn8p	30	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	30	4	are	be	VBP
cord-012418-6ralcn8p	30	5	the	the	DT
cord-012418-6ralcn8p	30	6	most	most	RBS
cord-012418-6ralcn8p	30	7	closely	closely	RB
cord-012418-6ralcn8p	30	8	related	related	JJ
cord-012418-6ralcn8p	30	9	members	member	NNS
cord-012418-6ralcn8p	30	10	of	of	IN
cord-012418-6ralcn8p	30	11	the	the	DT
cord-012418-6ralcn8p	30	12	IRF	IRF	NNP
cord-012418-6ralcn8p	30	13	family	family	NN
cord-012418-6ralcn8p	30	14	with	with	IN
cord-012418-6ralcn8p	30	15	especially	especially	RB
cord-012418-6ralcn8p	30	16	high	high	JJ
cord-012418-6ralcn8p	30	17	conservation	conservation	NN
cord-012418-6ralcn8p	30	18	of	of	IN
cord-012418-6ralcn8p	30	19	the	the	DT
cord-012418-6ralcn8p	30	20	AIE	AIE	NNP
cord-012418-6ralcn8p	30	21	,	,	,
cord-012418-6ralcn8p	30	22	enabling	enable	VBG
cord-012418-6ralcn8p	30	23	formation	formation	NN
cord-012418-6ralcn8p	30	24	of	of	IN
cord-012418-6ralcn8p	30	25	functional	functional	JJ
cord-012418-6ralcn8p	30	26	heterodimers	heterodimer	NNS
cord-012418-6ralcn8p	30	27	and	and	CC
cord-012418-6ralcn8p	30	28	providing	provide	VBG
cord-012418-6ralcn8p	30	29	the	the	DT
cord-012418-6ralcn8p	30	30	basis	basis	NN
cord-012418-6ralcn8p	30	31	for	for	IN
cord-012418-6ralcn8p	30	32	the	the	DT
cord-012418-6ralcn8p	30	33	shared	share	VBN
cord-012418-6ralcn8p	30	34	activation	activation	NN
cord-012418-6ralcn8p	30	35	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	30	36	as	as	RB
cord-012418-6ralcn8p	30	37	well	well	RB
cord-012418-6ralcn8p	30	38	as	as	IN
cord-012418-6ralcn8p	30	39	the	the	DT
cord-012418-6ralcn8p	30	40	similar	similar	JJ
cord-012418-6ralcn8p	30	41	mode	mode	NN
cord-012418-6ralcn8p	30	42	of	of	IN
cord-012418-6ralcn8p	30	43	action	action	NN
cord-012418-6ralcn8p	30	44	[	[	-LRB-
cord-012418-6ralcn8p	30	45	24	24	CD
cord-012418-6ralcn8p	30	46	]	]	-RRB-
cord-012418-6ralcn8p	30	47	[	[	-LRB-
cord-012418-6ralcn8p	30	48	25	25	CD
cord-012418-6ralcn8p	30	49	]	]	-RRB-
cord-012418-6ralcn8p	30	50	[	[	-LRB-
cord-012418-6ralcn8p	30	51	26	26	CD
cord-012418-6ralcn8p	30	52	]	]	-RRB-
cord-012418-6ralcn8p	30	53	.	.	.
cord-012418-6ralcn8p	31	1	Only	only	RB
cord-012418-6ralcn8p	31	2	in	in	IN
cord-012418-6ralcn8p	31	3	plasmacytoid	plasmacytoid	NNP
cord-012418-6ralcn8p	31	4	dendritic	dendritic	JJ
cord-012418-6ralcn8p	31	5	cells	cell	NNS
cord-012418-6ralcn8p	31	6	and	and	CC
cord-012418-6ralcn8p	31	7	macrophages	macrophage	NNS
cord-012418-6ralcn8p	31	8	,	,	,
cord-012418-6ralcn8p	31	9	IRF7	IRF7	NNP
cord-012418-6ralcn8p	31	10	is	be	VBZ
cord-012418-6ralcn8p	31	11	continuously	continuously	RB
cord-012418-6ralcn8p	31	12	expressed	express	VBN
cord-012418-6ralcn8p	31	13	at	at	IN
cord-012418-6ralcn8p	31	14	high	high	JJ
cord-012418-6ralcn8p	31	15	levels	level	NNS
cord-012418-6ralcn8p	31	16	and	and	CC
cord-012418-6ralcn8p	31	17	crucial	crucial	JJ
cord-012418-6ralcn8p	31	18	for	for	IN
cord-012418-6ralcn8p	31	19	the	the	DT
cord-012418-6ralcn8p	31	20	control	control	NN
cord-012418-6ralcn8p	31	21	of	of	IN
cord-012418-6ralcn8p	31	22	type	type	NN
cord-012418-6ralcn8p	32	1	I	-PRON-	PRP
cord-012418-6ralcn8p	32	2	IFN	IFN	NNP
cord-012418-6ralcn8p	32	3	induction	induction	NN
cord-012418-6ralcn8p	32	4	following	follow	VBG
cord-012418-6ralcn8p	32	5	TLR7	TLR7	NNP
cord-012418-6ralcn8p	32	6	and	and	CC
cord-012418-6ralcn8p	32	7	TLR9	tlr9	CD
cord-012418-6ralcn8p	32	8	engagement	engagement	NN
cord-012418-6ralcn8p	33	1	[	[	-LRB-
cord-012418-6ralcn8p	33	2	27	27	CD
cord-012418-6ralcn8p	33	3	]	]	-RRB-
cord-012418-6ralcn8p	33	4	.	.	.
cord-012418-6ralcn8p	34	1	Since	since	IN
cord-012418-6ralcn8p	34	2	these	these	DT
cord-012418-6ralcn8p	34	3	immune	immune	JJ
cord-012418-6ralcn8p	34	4	cells	cell	NNS
cord-012418-6ralcn8p	34	5	produce	produce	VBP
cord-012418-6ralcn8p	34	6	the	the	DT
cord-012418-6ralcn8p	34	7	major	major	JJ
cord-012418-6ralcn8p	34	8	share	share	NN
cord-012418-6ralcn8p	34	9	of	of	IN
cord-012418-6ralcn8p	34	10	type	type	NN
cord-012418-6ralcn8p	34	11	I	-PRON-	PRP
cord-012418-6ralcn8p	34	12	IFNs	ifns	VBP
cord-012418-6ralcn8p	34	13	in	in	IN
cord-012418-6ralcn8p	34	14	an	an	DT
cord-012418-6ralcn8p	34	15	infected	infected	JJ
cord-012418-6ralcn8p	34	16	host	host	NN
cord-012418-6ralcn8p	34	17	organism	organism	NN
cord-012418-6ralcn8p	34	18	,	,	,
cord-012418-6ralcn8p	34	19	IRF7	IRF7	NNP
cord-012418-6ralcn8p	34	20	was	be	VBD
cord-012418-6ralcn8p	34	21	termed	term	VBN
cord-012418-6ralcn8p	34	22	the	the	DT
cord-012418-6ralcn8p	34	23	"	"	``
cord-012418-6ralcn8p	34	24	master	master	NN
cord-012418-6ralcn8p	34	25	regulator	regulator	NN
cord-012418-6ralcn8p	34	26	"	"	''
cord-012418-6ralcn8p	34	27	of	of	IN
cord-012418-6ralcn8p	34	28	IFN	IFN	NNP
cord-012418-6ralcn8p	34	29	expression	expression	NN
cord-012418-6ralcn8p	34	30	(	(	-LRB-
cord-012418-6ralcn8p	34	31	reviewed	review	VBN
cord-012418-6ralcn8p	34	32	in	in	IN
cord-012418-6ralcn8p	34	33	[	[	-LRB-
cord-012418-6ralcn8p	34	34	28	28	CD
cord-012418-6ralcn8p	34	35	,	,	,
cord-012418-6ralcn8p	34	36	29	29	CD
cord-012418-6ralcn8p	34	37	]	]	-RRB-
cord-012418-6ralcn8p	34	38	)	)	-RRB-
cord-012418-6ralcn8p	34	39	.	.	.
cord-012418-6ralcn8p	35	1	In	in	IN
cord-012418-6ralcn8p	35	2	most	most	JJS
cord-012418-6ralcn8p	35	3	other	other	JJ
cord-012418-6ralcn8p	35	4	cell	cell	NN
cord-012418-6ralcn8p	35	5	types	type	NNS
cord-012418-6ralcn8p	35	6	,	,	,
cord-012418-6ralcn8p	35	7	however	however	RB
cord-012418-6ralcn8p	35	8	,	,	,
cord-012418-6ralcn8p	35	9	IRF7	IRF7	NNP
cord-012418-6ralcn8p	35	10	is	be	VBZ
cord-012418-6ralcn8p	35	11	expressed	express	VBN
cord-012418-6ralcn8p	35	12	at	at	IN
cord-012418-6ralcn8p	35	13	very	very	RB
cord-012418-6ralcn8p	35	14	low	low	JJ
cord-012418-6ralcn8p	35	15	levels	level	NNS
cord-012418-6ralcn8p	35	16	in	in	IN
cord-012418-6ralcn8p	35	17	absence	absence	NN
cord-012418-6ralcn8p	35	18	of	of	IN
cord-012418-6ralcn8p	35	19	stimulation	stimulation	NN
cord-012418-6ralcn8p	35	20	[	[	-LRB-
cord-012418-6ralcn8p	35	21	30	30	CD
cord-012418-6ralcn8p	35	22	]	]	-RRB-
cord-012418-6ralcn8p	35	23	.	.	.
cord-012418-6ralcn8p	36	1	In	in	IN
cord-012418-6ralcn8p	36	2	contrast	contrast	NN
cord-012418-6ralcn8p	36	3	to	to	IN
cord-012418-6ralcn8p	36	4	the	the	DT
cord-012418-6ralcn8p	36	5	ubiquitous	ubiquitous	JJ
cord-012418-6ralcn8p	36	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	36	7	,	,	,
cord-012418-6ralcn8p	36	8	participation	participation	NN
cord-012418-6ralcn8p	36	9	of	of	IN
cord-012418-6ralcn8p	36	10	IRF7	IRF7	NNP
cord-012418-6ralcn8p	36	11	molecules	molecule	NNS
cord-012418-6ralcn8p	36	12	seems	seem	VBZ
cord-012418-6ralcn8p	36	13	less	less	RBR
cord-012418-6ralcn8p	36	14	relevant	relevant	JJ
cord-012418-6ralcn8p	36	15	during	during	IN
cord-012418-6ralcn8p	36	16	the	the	DT
cord-012418-6ralcn8p	36	17	very	very	RB
cord-012418-6ralcn8p	36	18	first	first	JJ
cord-012418-6ralcn8p	36	19	response	response	NN
cord-012418-6ralcn8p	36	20	to	to	IN
cord-012418-6ralcn8p	36	21	virus	virus	NN
cord-012418-6ralcn8p	36	22	detection	detection	NN
cord-012418-6ralcn8p	36	23	at	at	IN
cord-012418-6ralcn8p	36	24	initial	initial	JJ
cord-012418-6ralcn8p	36	25	viral	viral	JJ
cord-012418-6ralcn8p	36	26	entry	entry	NN
cord-012418-6ralcn8p	36	27	sites	site	NNS
cord-012418-6ralcn8p	36	28	,	,	,
cord-012418-6ralcn8p	36	29	which	which	WDT
cord-012418-6ralcn8p	36	30	are	be	VBP
cord-012418-6ralcn8p	36	31	usually	usually	RB
cord-012418-6ralcn8p	36	32	composed	compose	VBN
cord-012418-6ralcn8p	36	33	of	of	IN
cord-012418-6ralcn8p	36	34	epithelial	epithelial	JJ
cord-012418-6ralcn8p	36	35	or	or	CC
cord-012418-6ralcn8p	36	36	endothelial	endothelial	JJ
cord-012418-6ralcn8p	36	37	cells	cell	NNS
cord-012418-6ralcn8p	36	38	or	or	CC
cord-012418-6ralcn8p	36	39	fibroblasts	fibroblast	NNS
cord-012418-6ralcn8p	36	40	.	.	.
cord-012418-6ralcn8p	37	1	Nevertheless	nevertheless	RB
cord-012418-6ralcn8p	37	2	,	,	,
cord-012418-6ralcn8p	37	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	37	4	is	be	VBZ
cord-012418-6ralcn8p	37	5	an	an	DT
cord-012418-6ralcn8p	37	6	important	important	JJ
cord-012418-6ralcn8p	37	7	contributor	contributor	NN
cord-012418-6ralcn8p	37	8	of	of	IN
cord-012418-6ralcn8p	37	9	the	the	DT
cord-012418-6ralcn8p	37	10	type	type	NN
cord-012418-6ralcn8p	37	11	I	-PRON-	PRP
cord-012418-6ralcn8p	37	12	IFN	IFN	NNP
cord-012418-6ralcn8p	37	13	response	response	NN
cord-012418-6ralcn8p	37	14	.	.	.
cord-012418-6ralcn8p	38	1	Upon	upon	IN
cord-012418-6ralcn8p	38	2	IFNα	IFNα	NNP
cord-012418-6ralcn8p	38	3	/	/	SYM
cord-012418-6ralcn8p	38	4	β	β	NN
cord-012418-6ralcn8p	38	5	signalling	signal	VBG
cord-012418-6ralcn8p	38	6	via	via	IN
cord-012418-6ralcn8p	38	7	the	the	DT
cord-012418-6ralcn8p	38	8	interferon	interferon	NN
cord-012418-6ralcn8p	38	9	-	-	HYPH
cord-012418-6ralcn8p	38	10	alpha	alpha	NN
cord-012418-6ralcn8p	38	11	/	/	SYM
cord-012418-6ralcn8p	38	12	beta	beta	NN
cord-012418-6ralcn8p	38	13	receptor	receptor	NN
cord-012418-6ralcn8p	38	14	(	(	-LRB-
cord-012418-6ralcn8p	38	15	IFNAR	IFNAR	NNP
cord-012418-6ralcn8p	38	16	)	)	-RRB-
cord-012418-6ralcn8p	38	17	,	,	,
cord-012418-6ralcn8p	38	18	IRF7	IRF7	NNP
cord-012418-6ralcn8p	38	19	expression	expression	NN
cord-012418-6ralcn8p	38	20	is	be	VBZ
cord-012418-6ralcn8p	38	21	highly	highly	RB
cord-012418-6ralcn8p	38	22	induced	induce	VBN
cord-012418-6ralcn8p	38	23	as	as	IN
cord-012418-6ralcn8p	38	24	part	part	NN
cord-012418-6ralcn8p	38	25	of	of	IN
cord-012418-6ralcn8p	38	26	the	the	DT
cord-012418-6ralcn8p	38	27	positive	positive	JJ
cord-012418-6ralcn8p	38	28	feedback	feedback	NN
cord-012418-6ralcn8p	38	29	regulation	regulation	NN
cord-012418-6ralcn8p	38	30	of	of	IN
cord-012418-6ralcn8p	38	31	the	the	DT
cord-012418-6ralcn8p	38	32	antiviral	antiviral	JJ
cord-012418-6ralcn8p	38	33	response	response	NN
cord-012418-6ralcn8p	38	34	;	;	:
cord-012418-6ralcn8p	38	35	in	in	IN
cord-012418-6ralcn8p	38	36	other	other	JJ
cord-012418-6ralcn8p	38	37	terms	term	NNS
cord-012418-6ralcn8p	38	38	,	,	,
cord-012418-6ralcn8p	38	39	IRF7	IRF7	NNP
cord-012418-6ralcn8p	38	40	is	be	VBZ
cord-012418-6ralcn8p	38	41	the	the	DT
cord-012418-6ralcn8p	38	42	product	product	NN
cord-012418-6ralcn8p	38	43	of	of	IN
cord-012418-6ralcn8p	38	44	an	an	DT
cord-012418-6ralcn8p	38	45	IFN	IFN	NNP
cord-012418-6ralcn8p	38	46	-	-	HYPH
cord-012418-6ralcn8p	38	47	stimulated	stimulate	VBN
cord-012418-6ralcn8p	38	48	gene	gene	NN
cord-012418-6ralcn8p	38	49	(	(	-LRB-
cord-012418-6ralcn8p	38	50	ISG	ISG	NNP
cord-012418-6ralcn8p	38	51	)	)	-RRB-
cord-012418-6ralcn8p	38	52	[	[	-LRB-
cord-012418-6ralcn8p	38	53	31	31	CD
cord-012418-6ralcn8p	38	54	]	]	-RRB-
cord-012418-6ralcn8p	38	55	.	.	.
cord-012418-6ralcn8p	39	1	Newly	newly	RB
cord-012418-6ralcn8p	39	2	synthesized	synthesize	VBN
cord-012418-6ralcn8p	39	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	39	4	undergoes	undergo	VBZ
cord-012418-6ralcn8p	39	5	an	an	DT
cord-012418-6ralcn8p	39	6	activation	activation	NN
cord-012418-6ralcn8p	39	7	similar	similar	JJ
cord-012418-6ralcn8p	39	8	to	to	IN
cord-012418-6ralcn8p	39	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	39	10	and	and	CC
cord-012418-6ralcn8p	39	11	in	in	IN
cord-012418-6ralcn8p	39	12	concert	concert	NN
cord-012418-6ralcn8p	39	13	with	with	IN
cord-012418-6ralcn8p	39	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	39	15	further	further	RB
cord-012418-6ralcn8p	39	16	amplifies	amplify	VBZ
cord-012418-6ralcn8p	39	17	transcription	transcription	NN
cord-012418-6ralcn8p	39	18	of	of	IN
cord-012418-6ralcn8p	39	19	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	39	20	.	.	.
cord-012418-6ralcn8p	40	1	This	this	DT
cord-012418-6ralcn8p	40	2	behaviour	behaviour	NN
cord-012418-6ralcn8p	40	3	can	can	MD
cord-012418-6ralcn8p	40	4	interfere	interfere	VB
cord-012418-6ralcn8p	40	5	with	with	IN
cord-012418-6ralcn8p	40	6	studies	study	NNS
cord-012418-6ralcn8p	40	7	focused	focus	VBN
cord-012418-6ralcn8p	40	8	on	on	IN
cord-012418-6ralcn8p	40	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	40	10	activity	activity	NN
cord-012418-6ralcn8p	40	11	or	or	CC
cord-012418-6ralcn8p	40	12	modulation	modulation	NN
cord-012418-6ralcn8p	40	13	thereof	thereof	RB
cord-012418-6ralcn8p	40	14	in	in	IN
cord-012418-6ralcn8p	40	15	later	later	JJ
cord-012418-6ralcn8p	40	16	stages	stage	NNS
cord-012418-6ralcn8p	40	17	.	.	.
cord-012418-6ralcn8p	41	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	41	2	is	be	VBZ
cord-012418-6ralcn8p	41	3	degraded	degrade	VBN
cord-012418-6ralcn8p	41	4	in	in	IN
cord-012418-6ralcn8p	41	5	the	the	DT
cord-012418-6ralcn8p	41	6	course	course	NN
cord-012418-6ralcn8p	41	7	of	of	IN
cord-012418-6ralcn8p	41	8	its	-PRON-	PRP$
cord-012418-6ralcn8p	41	9	activity	activity	NN
cord-012418-6ralcn8p	41	10	,	,	,
cord-012418-6ralcn8p	41	11	as	as	IN
cord-012418-6ralcn8p	41	12	discussed	discuss	VBN
cord-012418-6ralcn8p	41	13	below	below	RB
cord-012418-6ralcn8p	41	14	(	(	-LRB-
cord-012418-6ralcn8p	41	15	see	see	VB
cord-012418-6ralcn8p	41	16	Section	section	NN
cord-012418-6ralcn8p	41	17	4.3	4.3	CD
cord-012418-6ralcn8p	41	18	)	)	-RRB-
cord-012418-6ralcn8p	41	19	,	,	,
cord-012418-6ralcn8p	41	20	while	while	IN
cord-012418-6ralcn8p	41	21	IRF7	IRF7	NNP
cord-012418-6ralcn8p	41	22	,	,	,
cord-012418-6ralcn8p	41	23	though	though	IN
cord-012418-6ralcn8p	41	24	quickly	quickly	RB
cord-012418-6ralcn8p	41	25	degraded	degrade	VBN
cord-012418-6ralcn8p	41	26	,	,	,
cord-012418-6ralcn8p	41	27	is	be	VBZ
cord-012418-6ralcn8p	41	28	constantly	constantly	RB
cord-012418-6ralcn8p	41	29	expressed	express	VBN
cord-012418-6ralcn8p	41	30	during	during	IN
cord-012418-6ralcn8p	41	31	stimulation	stimulation	NN
cord-012418-6ralcn8p	41	32	[	[	-LRB-
cord-012418-6ralcn8p	41	33	28	28	CD
cord-012418-6ralcn8p	41	34	]	]	-RRB-
cord-012418-6ralcn8p	41	35	.	.	.
cord-012418-6ralcn8p	42	1	This	this	DT
cord-012418-6ralcn8p	42	2	shifts	shift	VBZ
cord-012418-6ralcn8p	42	3	the	the	DT
cord-012418-6ralcn8p	42	4	control	control	NN
cord-012418-6ralcn8p	42	5	of	of	IN
cord-012418-6ralcn8p	42	6	gene	gene	NN
cord-012418-6ralcn8p	42	7	expression	expression	NN
cord-012418-6ralcn8p	42	8	in	in	IN
cord-012418-6ralcn8p	42	9	fibroblasts	fibroblast	NNS
cord-012418-6ralcn8p	42	10	,	,	,
cord-012418-6ralcn8p	42	11	epithelial	epithelial	JJ
cord-012418-6ralcn8p	42	12	and	and	CC
cord-012418-6ralcn8p	42	13	endothelial	endothelial	JJ
cord-012418-6ralcn8p	42	14	cells	cell	NNS
cord-012418-6ralcn8p	42	15	from	from	IN
cord-012418-6ralcn8p	42	16	IRF3-mediated	irf3-mediate	VBN
cord-012418-6ralcn8p	42	17	regulation	regulation	NN
cord-012418-6ralcn8p	42	18	upon	upon	IN
cord-012418-6ralcn8p	42	19	initial	initial	JJ
cord-012418-6ralcn8p	42	20	sensing	sensing	NN
cord-012418-6ralcn8p	42	21	of	of	IN
cord-012418-6ralcn8p	42	22	an	an	DT
cord-012418-6ralcn8p	42	23	infection	infection	NN
cord-012418-6ralcn8p	42	24	towards	towards	IN
cord-012418-6ralcn8p	42	25	IRF7-mediated	irf7-mediate	VBN
cord-012418-6ralcn8p	42	26	in	in	IN
cord-012418-6ralcn8p	42	27	later	later	JJ
cord-012418-6ralcn8p	42	28	phases	phase	NNS
cord-012418-6ralcn8p	42	29	[	[	-LRB-
cord-012418-6ralcn8p	42	30	32	32	CD
cord-012418-6ralcn8p	42	31	]	]	-RRB-
cord-012418-6ralcn8p	43	1	[	[	-LRB-
cord-012418-6ralcn8p	43	2	33	33	CD
cord-012418-6ralcn8p	43	3	]	]	-RRB-
cord-012418-6ralcn8p	43	4	[	[	-LRB-
cord-012418-6ralcn8p	43	5	34	34	CD
cord-012418-6ralcn8p	43	6	]	]	-RRB-
cord-012418-6ralcn8p	43	7	.	.	.
cord-012418-6ralcn8p	44	1	Knockout	knockout	NN
cord-012418-6ralcn8p	44	2	experiments	experiment	NNS
cord-012418-6ralcn8p	44	3	in	in	IN
cord-012418-6ralcn8p	44	4	mice	mouse	NNS
cord-012418-6ralcn8p	44	5	have	have	VBP
cord-012418-6ralcn8p	44	6	shown	show	VBN
cord-012418-6ralcn8p	44	7	that	that	DT
cord-012418-6ralcn8p	44	8	lack	lack	NN
cord-012418-6ralcn8p	44	9	consists	consist	VBZ
cord-012418-6ralcn8p	44	10	of	of	IN
cord-012418-6ralcn8p	44	11	an	an	DT
cord-012418-6ralcn8p	44	12	N	n	CD
cord-012418-6ralcn8p	44	13	-	-	HYPH
cord-012418-6ralcn8p	44	14	terminal	terminal	JJ
cord-012418-6ralcn8p	44	15	DNA	dna	NN
cord-012418-6ralcn8p	44	16	-	-	HYPH
cord-012418-6ralcn8p	44	17	binding	bind	VBG
cord-012418-6ralcn8p	44	18	domain	domain	NN
cord-012418-6ralcn8p	44	19	(	(	-LRB-
cord-012418-6ralcn8p	44	20	DBD	DBD	NNP
cord-012418-6ralcn8p	44	21	)	)	-RRB-
cord-012418-6ralcn8p	44	22	linked	link	VBN
cord-012418-6ralcn8p	44	23	by	by	IN
cord-012418-6ralcn8p	44	24	a	a	DT
cord-012418-6ralcn8p	44	25	flexible	flexible	JJ
cord-012418-6ralcn8p	44	26	region	region	NN
cord-012418-6ralcn8p	44	27	to	to	IN
cord-012418-6ralcn8p	44	28	the	the	DT
cord-012418-6ralcn8p	44	29	C	C	NNP
cord-012418-6ralcn8p	44	30	-	-	HYPH
cord-012418-6ralcn8p	44	31	terminal	terminal	NN
cord-012418-6ralcn8p	44	32	IRF	IRF	NNP
cord-012418-6ralcn8p	44	33	association	association	NN
cord-012418-6ralcn8p	44	34	domain	domain	NN
cord-012418-6ralcn8p	44	35	(	(	-LRB-
cord-012418-6ralcn8p	44	36	IAD	IAD	NNP
cord-012418-6ralcn8p	44	37	)	)	-RRB-
cord-012418-6ralcn8p	44	38	.	.	.
cord-012418-6ralcn8p	45	1	In	in	IN
cord-012418-6ralcn8p	45	2	the	the	DT
cord-012418-6ralcn8p	45	3	latent	latent	JJ
cord-012418-6ralcn8p	45	4	state	state	NN
cord-012418-6ralcn8p	45	5	,	,	,
cord-012418-6ralcn8p	45	6	a	a	DT
cord-012418-6ralcn8p	45	7	part	part	NN
cord-012418-6ralcn8p	45	8	of	of	IN
cord-012418-6ralcn8p	45	9	the	the	DT
cord-012418-6ralcn8p	45	10	linker	linker	NN
cord-012418-6ralcn8p	45	11	and	and	CC
cord-012418-6ralcn8p	45	12	the	the	DT
cord-012418-6ralcn8p	45	13	most	most	JJS
cord-012418-6ralcn8p	45	14	C	c	NN
cord-012418-6ralcn8p	45	15	-	-	HYPH
cord-012418-6ralcn8p	45	16	terminal	terminal	NN
cord-012418-6ralcn8p	45	17	portion	portion	NN
cord-012418-6ralcn8p	45	18	form	form	NN
cord-012418-6ralcn8p	45	19	auto	auto	NN
cord-012418-6ralcn8p	45	20	-	-	HYPH
cord-012418-6ralcn8p	45	21	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	45	22	elements	element	NNS
cord-012418-6ralcn8p	45	23	(	(	-LRB-
cord-012418-6ralcn8p	45	24	AIEs	AIEs	NNP
cord-012418-6ralcn8p	45	25	)	)	-RRB-
cord-012418-6ralcn8p	45	26	.	.	.
cord-012418-6ralcn8p	46	1	Phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	46	2	of	of	IN
cord-012418-6ralcn8p	46	3	two	two	CD
cord-012418-6ralcn8p	46	4	serine	serine	JJ
cord-012418-6ralcn8p	46	5	-	-	HYPH
cord-012418-6ralcn8p	46	6	rich	rich	JJ
cord-012418-6ralcn8p	46	7	clusters	cluster	NNS
cord-012418-6ralcn8p	46	8	(	(	-LRB-
cord-012418-6ralcn8p	46	9	c1	c1	NNP
cord-012418-6ralcn8p	46	10	and	and	CC
cord-012418-6ralcn8p	46	11	c2	c2	NNP
cord-012418-6ralcn8p	46	12	)	)	-RRB-
cord-012418-6ralcn8p	46	13	induces	induce	VBZ
cord-012418-6ralcn8p	46	14	conformational	conformational	JJ
cord-012418-6ralcn8p	46	15	rearrangements	rearrangement	NNS
cord-012418-6ralcn8p	46	16	of	of	IN
cord-012418-6ralcn8p	46	17	the	the	DT
cord-012418-6ralcn8p	46	18	AIEs	aie	NNS
cord-012418-6ralcn8p	46	19	and	and	CC
cord-012418-6ralcn8p	46	20	frees	free	VBZ
cord-012418-6ralcn8p	46	21	the	the	DT
cord-012418-6ralcn8p	46	22	IAD	IAD	NNP
cord-012418-6ralcn8p	46	23	to	to	TO
cord-012418-6ralcn8p	46	24	participate	participate	VB
cord-012418-6ralcn8p	46	25	in	in	IN
cord-012418-6ralcn8p	46	26	protein	protein	NN
cord-012418-6ralcn8p	46	27	-	-	HYPH
cord-012418-6ralcn8p	46	28	protein	protein	NN
cord-012418-6ralcn8p	46	29	interactions	interaction	NNS
cord-012418-6ralcn8p	46	30	with	with	IN
cord-012418-6ralcn8p	46	31	coactivators	coactivator	NNS
cord-012418-6ralcn8p	46	32	and	and	CC
cord-012418-6ralcn8p	46	33	for	for	IN
cord-012418-6ralcn8p	46	34	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	46	35	via	via	IN
cord-012418-6ralcn8p	46	36	the	the	DT
cord-012418-6ralcn8p	46	37	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	46	38	pLxIS	plxis	NN
cord-012418-6ralcn8p	46	39	motif	motif	NN
cord-012418-6ralcn8p	46	40	(	(	-LRB-
cord-012418-6ralcn8p	46	41	p	p	NN
cord-012418-6ralcn8p	46	42	:	:	:
cord-012418-6ralcn8p	46	43	hydrophilic	hydrophilic	JJ
cord-012418-6ralcn8p	46	44	,	,	,
cord-012418-6ralcn8p	47	1	x	x	LS
cord-012418-6ralcn8p	47	2	:	:	:
cord-012418-6ralcn8p	47	3	any	any	DT
cord-012418-6ralcn8p	47	4	amino	amino	NN
cord-012418-6ralcn8p	47	5	acid	acid	NN
cord-012418-6ralcn8p	47	6	)	)	-RRB-
cord-012418-6ralcn8p	47	7	.	.	.
cord-012418-6ralcn8p	48	1	The	the	DT
cord-012418-6ralcn8p	48	2	protein	protein	NN
cord-012418-6ralcn8p	48	3	further	further	RB
cord-012418-6ralcn8p	48	4	contains	contain	VBZ
cord-012418-6ralcn8p	48	5	a	a	DT
cord-012418-6ralcn8p	48	6	nuclear	nuclear	JJ
cord-012418-6ralcn8p	48	7	localization	localization	NN
cord-012418-6ralcn8p	48	8	signal	signal	NN
cord-012418-6ralcn8p	48	9	(	(	-LRB-
cord-012418-6ralcn8p	48	10	NLS	NLS	NNP
cord-012418-6ralcn8p	48	11	)	)	-RRB-
cord-012418-6ralcn8p	48	12	and	and	CC
cord-012418-6ralcn8p	48	13	a	a	DT
cord-012418-6ralcn8p	48	14	nuclear	nuclear	JJ
cord-012418-6ralcn8p	48	15	exit	exit	NN
cord-012418-6ralcn8p	48	16	signal	signal	NN
cord-012418-6ralcn8p	48	17	(	(	-LRB-
cord-012418-6ralcn8p	48	18	NES	NES	NNP
cord-012418-6ralcn8p	48	19	)	)	-RRB-
cord-012418-6ralcn8p	48	20	that	that	WDT
cord-012418-6ralcn8p	48	21	enable	enable	VBP
cord-012418-6ralcn8p	48	22	constitutive	constitutive	JJ
cord-012418-6ralcn8p	48	23	shuttling	shuttling	NN
cord-012418-6ralcn8p	48	24	between	between	IN
cord-012418-6ralcn8p	48	25	the	the	DT
cord-012418-6ralcn8p	48	26	cytosol	cytosol	NN
cord-012418-6ralcn8p	48	27	and	and	CC
cord-012418-6ralcn8p	48	28	nucleus	nucleus	NN
cord-012418-6ralcn8p	48	29	.	.	.
cord-012418-6ralcn8p	49	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	49	2	and	and	CC
cord-012418-6ralcn8p	49	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	49	4	are	be	VBP
cord-012418-6ralcn8p	49	5	the	the	DT
cord-012418-6ralcn8p	49	6	most	most	RBS
cord-012418-6ralcn8p	49	7	closely	closely	RB
cord-012418-6ralcn8p	49	8	related	related	JJ
cord-012418-6ralcn8p	49	9	members	member	NNS
cord-012418-6ralcn8p	49	10	of	of	IN
cord-012418-6ralcn8p	49	11	the	the	DT
cord-012418-6ralcn8p	49	12	IRF	IRF	NNP
cord-012418-6ralcn8p	49	13	family	family	NN
cord-012418-6ralcn8p	49	14	with	with	IN
cord-012418-6ralcn8p	49	15	especially	especially	RB
cord-012418-6ralcn8p	49	16	high	high	JJ
cord-012418-6ralcn8p	49	17	conservation	conservation	NN
cord-012418-6ralcn8p	49	18	of	of	IN
cord-012418-6ralcn8p	49	19	the	the	DT
cord-012418-6ralcn8p	49	20	AIE	AIE	NNP
cord-012418-6ralcn8p	49	21	,	,	,
cord-012418-6ralcn8p	49	22	enabling	enable	VBG
cord-012418-6ralcn8p	49	23	formation	formation	NN
cord-012418-6ralcn8p	49	24	of	of	IN
cord-012418-6ralcn8p	49	25	functional	functional	JJ
cord-012418-6ralcn8p	49	26	heterodimers	heterodimer	NNS
cord-012418-6ralcn8p	49	27	and	and	CC
cord-012418-6ralcn8p	49	28	providing	provide	VBG
cord-012418-6ralcn8p	49	29	the	the	DT
cord-012418-6ralcn8p	49	30	basis	basis	NN
cord-012418-6ralcn8p	49	31	for	for	IN
cord-012418-6ralcn8p	49	32	the	the	DT
cord-012418-6ralcn8p	49	33	shared	share	VBN
cord-012418-6ralcn8p	49	34	activation	activation	NN
cord-012418-6ralcn8p	49	35	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	49	36	as	as	RB
cord-012418-6ralcn8p	49	37	well	well	RB
cord-012418-6ralcn8p	49	38	as	as	IN
cord-012418-6ralcn8p	49	39	the	the	DT
cord-012418-6ralcn8p	49	40	similar	similar	JJ
cord-012418-6ralcn8p	49	41	mode	mode	NN
cord-012418-6ralcn8p	49	42	of	of	IN
cord-012418-6ralcn8p	49	43	action	action	NN
cord-012418-6ralcn8p	49	44	[	[	-LRB-
cord-012418-6ralcn8p	49	45	24	24	CD
cord-012418-6ralcn8p	49	46	]	]	-RRB-
cord-012418-6ralcn8p	49	47	[	[	-LRB-
cord-012418-6ralcn8p	49	48	25	25	CD
cord-012418-6ralcn8p	49	49	]	]	-RRB-
cord-012418-6ralcn8p	49	50	[	[	-LRB-
cord-012418-6ralcn8p	49	51	26	26	CD
cord-012418-6ralcn8p	49	52	]	]	-RRB-
cord-012418-6ralcn8p	49	53	.	.	.
cord-012418-6ralcn8p	50	1	Only	only	RB
cord-012418-6ralcn8p	50	2	in	in	IN
cord-012418-6ralcn8p	50	3	plasmacytoid	plasmacytoid	NNP
cord-012418-6ralcn8p	50	4	dendritic	dendritic	JJ
cord-012418-6ralcn8p	50	5	cells	cell	NNS
cord-012418-6ralcn8p	50	6	and	and	CC
cord-012418-6ralcn8p	50	7	macrophages	macrophage	NNS
cord-012418-6ralcn8p	50	8	,	,	,
cord-012418-6ralcn8p	50	9	IRF7	IRF7	NNP
cord-012418-6ralcn8p	50	10	is	be	VBZ
cord-012418-6ralcn8p	50	11	continuously	continuously	RB
cord-012418-6ralcn8p	50	12	expressed	express	VBN
cord-012418-6ralcn8p	50	13	at	at	IN
cord-012418-6ralcn8p	50	14	high	high	JJ
cord-012418-6ralcn8p	50	15	levels	level	NNS
cord-012418-6ralcn8p	50	16	and	and	CC
cord-012418-6ralcn8p	50	17	crucial	crucial	JJ
cord-012418-6ralcn8p	50	18	for	for	IN
cord-012418-6ralcn8p	50	19	the	the	DT
cord-012418-6ralcn8p	50	20	control	control	NN
cord-012418-6ralcn8p	50	21	of	of	IN
cord-012418-6ralcn8p	50	22	type	type	NN
cord-012418-6ralcn8p	51	1	I	-PRON-	PRP
cord-012418-6ralcn8p	51	2	IFN	IFN	NNP
cord-012418-6ralcn8p	51	3	induction	induction	NN
cord-012418-6ralcn8p	51	4	following	follow	VBG
cord-012418-6ralcn8p	51	5	TLR7	TLR7	NNP
cord-012418-6ralcn8p	51	6	and	and	CC
cord-012418-6ralcn8p	51	7	TLR9	tlr9	CD
cord-012418-6ralcn8p	51	8	engagement	engagement	NN
cord-012418-6ralcn8p	52	1	[	[	-LRB-
cord-012418-6ralcn8p	52	2	27	27	CD
cord-012418-6ralcn8p	52	3	]	]	-RRB-
cord-012418-6ralcn8p	52	4	.	.	.
cord-012418-6ralcn8p	53	1	Since	since	IN
cord-012418-6ralcn8p	53	2	these	these	DT
cord-012418-6ralcn8p	53	3	immune	immune	JJ
cord-012418-6ralcn8p	53	4	cells	cell	NNS
cord-012418-6ralcn8p	53	5	produce	produce	VBP
cord-012418-6ralcn8p	53	6	the	the	DT
cord-012418-6ralcn8p	53	7	major	major	JJ
cord-012418-6ralcn8p	53	8	share	share	NN
cord-012418-6ralcn8p	53	9	of	of	IN
cord-012418-6ralcn8p	53	10	type	type	NN
cord-012418-6ralcn8p	53	11	I	-PRON-	PRP
cord-012418-6ralcn8p	53	12	IFNs	ifns	VBP
cord-012418-6ralcn8p	53	13	in	in	IN
cord-012418-6ralcn8p	53	14	an	an	DT
cord-012418-6ralcn8p	53	15	infected	infected	JJ
cord-012418-6ralcn8p	53	16	host	host	NN
cord-012418-6ralcn8p	53	17	organism	organism	NN
cord-012418-6ralcn8p	53	18	,	,	,
cord-012418-6ralcn8p	53	19	IRF7	IRF7	NNP
cord-012418-6ralcn8p	53	20	was	be	VBD
cord-012418-6ralcn8p	53	21	termed	term	VBN
cord-012418-6ralcn8p	53	22	the	the	DT
cord-012418-6ralcn8p	53	23	"	"	``
cord-012418-6ralcn8p	53	24	master	master	NN
cord-012418-6ralcn8p	53	25	regulator	regulator	NN
cord-012418-6ralcn8p	53	26	"	"	''
cord-012418-6ralcn8p	53	27	of	of	IN
cord-012418-6ralcn8p	53	28	IFN	IFN	NNP
cord-012418-6ralcn8p	53	29	expression	expression	NN
cord-012418-6ralcn8p	53	30	(	(	-LRB-
cord-012418-6ralcn8p	53	31	reviewed	review	VBN
cord-012418-6ralcn8p	53	32	in	in	IN
cord-012418-6ralcn8p	53	33	[	[	-LRB-
cord-012418-6ralcn8p	53	34	28	28	CD
cord-012418-6ralcn8p	53	35	,	,	,
cord-012418-6ralcn8p	53	36	29	29	CD
cord-012418-6ralcn8p	53	37	]	]	-RRB-
cord-012418-6ralcn8p	53	38	)	)	-RRB-
cord-012418-6ralcn8p	53	39	.	.	.
cord-012418-6ralcn8p	54	1	In	in	IN
cord-012418-6ralcn8p	54	2	most	most	JJS
cord-012418-6ralcn8p	54	3	other	other	JJ
cord-012418-6ralcn8p	54	4	cell	cell	NN
cord-012418-6ralcn8p	54	5	types	type	NNS
cord-012418-6ralcn8p	54	6	,	,	,
cord-012418-6ralcn8p	54	7	however	however	RB
cord-012418-6ralcn8p	54	8	,	,	,
cord-012418-6ralcn8p	54	9	IRF7	IRF7	NNP
cord-012418-6ralcn8p	54	10	is	be	VBZ
cord-012418-6ralcn8p	54	11	expressed	express	VBN
cord-012418-6ralcn8p	54	12	at	at	IN
cord-012418-6ralcn8p	54	13	very	very	RB
cord-012418-6ralcn8p	54	14	low	low	JJ
cord-012418-6ralcn8p	54	15	levels	level	NNS
cord-012418-6ralcn8p	54	16	in	in	IN
cord-012418-6ralcn8p	54	17	absence	absence	NN
cord-012418-6ralcn8p	54	18	of	of	IN
cord-012418-6ralcn8p	54	19	stimulation	stimulation	NN
cord-012418-6ralcn8p	54	20	[	[	-LRB-
cord-012418-6ralcn8p	54	21	30	30	CD
cord-012418-6ralcn8p	54	22	]	]	-RRB-
cord-012418-6ralcn8p	54	23	.	.	.
cord-012418-6ralcn8p	55	1	In	in	IN
cord-012418-6ralcn8p	55	2	contrast	contrast	NN
cord-012418-6ralcn8p	55	3	to	to	IN
cord-012418-6ralcn8p	55	4	the	the	DT
cord-012418-6ralcn8p	55	5	ubiquitous	ubiquitous	JJ
cord-012418-6ralcn8p	55	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	55	7	,	,	,
cord-012418-6ralcn8p	55	8	participation	participation	NN
cord-012418-6ralcn8p	55	9	of	of	IN
cord-012418-6ralcn8p	55	10	IRF7	IRF7	NNP
cord-012418-6ralcn8p	55	11	molecules	molecule	NNS
cord-012418-6ralcn8p	55	12	seems	seem	VBZ
cord-012418-6ralcn8p	55	13	less	less	RBR
cord-012418-6ralcn8p	55	14	relevant	relevant	JJ
cord-012418-6ralcn8p	55	15	during	during	IN
cord-012418-6ralcn8p	55	16	the	the	DT
cord-012418-6ralcn8p	55	17	very	very	RB
cord-012418-6ralcn8p	55	18	first	first	JJ
cord-012418-6ralcn8p	55	19	response	response	NN
cord-012418-6ralcn8p	55	20	to	to	IN
cord-012418-6ralcn8p	55	21	virus	virus	NN
cord-012418-6ralcn8p	55	22	detection	detection	NN
cord-012418-6ralcn8p	55	23	at	at	IN
cord-012418-6ralcn8p	55	24	initial	initial	JJ
cord-012418-6ralcn8p	55	25	viral	viral	JJ
cord-012418-6ralcn8p	55	26	entry	entry	NN
cord-012418-6ralcn8p	55	27	sites	site	NNS
cord-012418-6ralcn8p	55	28	,	,	,
cord-012418-6ralcn8p	55	29	which	which	WDT
cord-012418-6ralcn8p	55	30	are	be	VBP
cord-012418-6ralcn8p	55	31	usually	usually	RB
cord-012418-6ralcn8p	55	32	composed	compose	VBN
cord-012418-6ralcn8p	55	33	of	of	IN
cord-012418-6ralcn8p	55	34	epithelial	epithelial	JJ
cord-012418-6ralcn8p	55	35	or	or	CC
cord-012418-6ralcn8p	55	36	endothelial	endothelial	JJ
cord-012418-6ralcn8p	55	37	cells	cell	NNS
cord-012418-6ralcn8p	55	38	or	or	CC
cord-012418-6ralcn8p	55	39	fibroblasts	fibroblast	NNS
cord-012418-6ralcn8p	55	40	.	.	.
cord-012418-6ralcn8p	56	1	Nevertheless	nevertheless	RB
cord-012418-6ralcn8p	56	2	,	,	,
cord-012418-6ralcn8p	56	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	56	4	is	be	VBZ
cord-012418-6ralcn8p	56	5	an	an	DT
cord-012418-6ralcn8p	56	6	important	important	JJ
cord-012418-6ralcn8p	56	7	contributor	contributor	NN
cord-012418-6ralcn8p	56	8	of	of	IN
cord-012418-6ralcn8p	56	9	the	the	DT
cord-012418-6ralcn8p	56	10	type	type	NN
cord-012418-6ralcn8p	56	11	I	-PRON-	PRP
cord-012418-6ralcn8p	56	12	IFN	IFN	NNP
cord-012418-6ralcn8p	56	13	response	response	NN
cord-012418-6ralcn8p	56	14	.	.	.
cord-012418-6ralcn8p	57	1	Upon	upon	IN
cord-012418-6ralcn8p	57	2	IFNα	IFNα	NNP
cord-012418-6ralcn8p	57	3	/	/	SYM
cord-012418-6ralcn8p	57	4	β	β	NN
cord-012418-6ralcn8p	57	5	signalling	signal	VBG
cord-012418-6ralcn8p	57	6	via	via	IN
cord-012418-6ralcn8p	57	7	the	the	DT
cord-012418-6ralcn8p	57	8	interferon	interferon	NN
cord-012418-6ralcn8p	57	9	-	-	HYPH
cord-012418-6ralcn8p	57	10	alpha	alpha	NN
cord-012418-6ralcn8p	57	11	/	/	SYM
cord-012418-6ralcn8p	57	12	beta	beta	NN
cord-012418-6ralcn8p	57	13	receptor	receptor	NN
cord-012418-6ralcn8p	57	14	(	(	-LRB-
cord-012418-6ralcn8p	57	15	IFNAR	IFNAR	NNP
cord-012418-6ralcn8p	57	16	)	)	-RRB-
cord-012418-6ralcn8p	57	17	,	,	,
cord-012418-6ralcn8p	57	18	IRF7	IRF7	NNP
cord-012418-6ralcn8p	57	19	expression	expression	NN
cord-012418-6ralcn8p	57	20	is	be	VBZ
cord-012418-6ralcn8p	57	21	highly	highly	RB
cord-012418-6ralcn8p	57	22	induced	induce	VBN
cord-012418-6ralcn8p	57	23	as	as	IN
cord-012418-6ralcn8p	57	24	part	part	NN
cord-012418-6ralcn8p	57	25	of	of	IN
cord-012418-6ralcn8p	57	26	the	the	DT
cord-012418-6ralcn8p	57	27	positive	positive	JJ
cord-012418-6ralcn8p	57	28	feedback	feedback	NN
cord-012418-6ralcn8p	57	29	regulation	regulation	NN
cord-012418-6ralcn8p	57	30	of	of	IN
cord-012418-6ralcn8p	57	31	the	the	DT
cord-012418-6ralcn8p	57	32	antiviral	antiviral	JJ
cord-012418-6ralcn8p	57	33	response	response	NN
cord-012418-6ralcn8p	57	34	;	;	:
cord-012418-6ralcn8p	57	35	in	in	IN
cord-012418-6ralcn8p	57	36	other	other	JJ
cord-012418-6ralcn8p	57	37	terms	term	NNS
cord-012418-6ralcn8p	57	38	,	,	,
cord-012418-6ralcn8p	57	39	IRF7	IRF7	NNP
cord-012418-6ralcn8p	57	40	is	be	VBZ
cord-012418-6ralcn8p	57	41	the	the	DT
cord-012418-6ralcn8p	57	42	product	product	NN
cord-012418-6ralcn8p	57	43	of	of	IN
cord-012418-6ralcn8p	57	44	an	an	DT
cord-012418-6ralcn8p	57	45	IFN	IFN	NNP
cord-012418-6ralcn8p	57	46	-	-	HYPH
cord-012418-6ralcn8p	57	47	stimulated	stimulate	VBN
cord-012418-6ralcn8p	57	48	gene	gene	NN
cord-012418-6ralcn8p	57	49	(	(	-LRB-
cord-012418-6ralcn8p	57	50	ISG	ISG	NNP
cord-012418-6ralcn8p	57	51	)	)	-RRB-
cord-012418-6ralcn8p	57	52	[	[	-LRB-
cord-012418-6ralcn8p	57	53	31	31	CD
cord-012418-6ralcn8p	57	54	]	]	-RRB-
cord-012418-6ralcn8p	57	55	.	.	.
cord-012418-6ralcn8p	58	1	Newly	newly	RB
cord-012418-6ralcn8p	58	2	synthesized	synthesize	VBN
cord-012418-6ralcn8p	58	3	IRF7	IRF7	NNP
cord-012418-6ralcn8p	58	4	undergoes	undergo	VBZ
cord-012418-6ralcn8p	58	5	an	an	DT
cord-012418-6ralcn8p	58	6	activation	activation	NN
cord-012418-6ralcn8p	58	7	similar	similar	JJ
cord-012418-6ralcn8p	58	8	to	to	IN
cord-012418-6ralcn8p	58	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	58	10	and	and	CC
cord-012418-6ralcn8p	58	11	in	in	IN
cord-012418-6ralcn8p	58	12	concert	concert	NN
cord-012418-6ralcn8p	58	13	with	with	IN
cord-012418-6ralcn8p	58	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	58	15	further	further	RB
cord-012418-6ralcn8p	58	16	amplifies	amplify	VBZ
cord-012418-6ralcn8p	58	17	transcription	transcription	NN
cord-012418-6ralcn8p	58	18	of	of	IN
cord-012418-6ralcn8p	58	19	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	58	20	.	.	.
cord-012418-6ralcn8p	59	1	This	this	DT
cord-012418-6ralcn8p	59	2	behaviour	behaviour	NN
cord-012418-6ralcn8p	59	3	can	can	MD
cord-012418-6ralcn8p	59	4	interfere	interfere	VB
cord-012418-6ralcn8p	59	5	with	with	IN
cord-012418-6ralcn8p	59	6	studies	study	NNS
cord-012418-6ralcn8p	59	7	focused	focus	VBN
cord-012418-6ralcn8p	59	8	on	on	IN
cord-012418-6ralcn8p	59	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	59	10	activity	activity	NN
cord-012418-6ralcn8p	59	11	or	or	CC
cord-012418-6ralcn8p	59	12	modulation	modulation	NN
cord-012418-6ralcn8p	59	13	thereof	thereof	RB
cord-012418-6ralcn8p	59	14	in	in	IN
cord-012418-6ralcn8p	59	15	later	later	JJ
cord-012418-6ralcn8p	59	16	stages	stage	NNS
cord-012418-6ralcn8p	59	17	.	.	.
cord-012418-6ralcn8p	60	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	60	2	is	be	VBZ
cord-012418-6ralcn8p	60	3	degraded	degrade	VBN
cord-012418-6ralcn8p	60	4	in	in	IN
cord-012418-6ralcn8p	60	5	the	the	DT
cord-012418-6ralcn8p	60	6	course	course	NN
cord-012418-6ralcn8p	60	7	of	of	IN
cord-012418-6ralcn8p	60	8	its	-PRON-	PRP$
cord-012418-6ralcn8p	60	9	activity	activity	NN
cord-012418-6ralcn8p	60	10	,	,	,
cord-012418-6ralcn8p	60	11	as	as	IN
cord-012418-6ralcn8p	60	12	discussed	discuss	VBN
cord-012418-6ralcn8p	60	13	below	below	RB
cord-012418-6ralcn8p	60	14	(	(	-LRB-
cord-012418-6ralcn8p	60	15	see	see	VB
cord-012418-6ralcn8p	60	16	Section	section	NN
cord-012418-6ralcn8p	60	17	4.3	4.3	CD
cord-012418-6ralcn8p	60	18	)	)	-RRB-
cord-012418-6ralcn8p	60	19	,	,	,
cord-012418-6ralcn8p	60	20	while	while	IN
cord-012418-6ralcn8p	60	21	IRF7	IRF7	NNP
cord-012418-6ralcn8p	60	22	,	,	,
cord-012418-6ralcn8p	60	23	though	though	IN
cord-012418-6ralcn8p	60	24	quickly	quickly	RB
cord-012418-6ralcn8p	60	25	degraded	degrade	VBN
cord-012418-6ralcn8p	60	26	,	,	,
cord-012418-6ralcn8p	60	27	is	be	VBZ
cord-012418-6ralcn8p	60	28	constantly	constantly	RB
cord-012418-6ralcn8p	60	29	expressed	express	VBN
cord-012418-6ralcn8p	60	30	during	during	IN
cord-012418-6ralcn8p	60	31	stimulation	stimulation	NN
cord-012418-6ralcn8p	60	32	[	[	-LRB-
cord-012418-6ralcn8p	60	33	28	28	CD
cord-012418-6ralcn8p	60	34	]	]	-RRB-
cord-012418-6ralcn8p	60	35	.	.	.
cord-012418-6ralcn8p	61	1	This	this	DT
cord-012418-6ralcn8p	61	2	shifts	shift	VBZ
cord-012418-6ralcn8p	61	3	the	the	DT
cord-012418-6ralcn8p	61	4	control	control	NN
cord-012418-6ralcn8p	61	5	of	of	IN
cord-012418-6ralcn8p	61	6	gene	gene	NN
cord-012418-6ralcn8p	61	7	expression	expression	NN
cord-012418-6ralcn8p	61	8	in	in	IN
cord-012418-6ralcn8p	61	9	fibroblasts	fibroblast	NNS
cord-012418-6ralcn8p	61	10	,	,	,
cord-012418-6ralcn8p	61	11	epithelial	epithelial	JJ
cord-012418-6ralcn8p	61	12	and	and	CC
cord-012418-6ralcn8p	61	13	endothelial	endothelial	JJ
cord-012418-6ralcn8p	61	14	cells	cell	NNS
cord-012418-6ralcn8p	61	15	from	from	IN
cord-012418-6ralcn8p	61	16	IRF3-mediated	irf3-mediate	VBN
cord-012418-6ralcn8p	61	17	regulation	regulation	NN
cord-012418-6ralcn8p	61	18	upon	upon	IN
cord-012418-6ralcn8p	61	19	initial	initial	JJ
cord-012418-6ralcn8p	61	20	sensing	sensing	NN
cord-012418-6ralcn8p	61	21	of	of	IN
cord-012418-6ralcn8p	61	22	an	an	DT
cord-012418-6ralcn8p	61	23	infection	infection	NN
cord-012418-6ralcn8p	61	24	towards	towards	IN
cord-012418-6ralcn8p	61	25	IRF7-mediated	irf7-mediate	VBN
cord-012418-6ralcn8p	61	26	in	in	IN
cord-012418-6ralcn8p	61	27	later	later	JJ
cord-012418-6ralcn8p	61	28	phases	phase	NNS
cord-012418-6ralcn8p	61	29	[	[	-LRB-
cord-012418-6ralcn8p	61	30	32	32	CD
cord-012418-6ralcn8p	61	31	]	]	-RRB-
cord-012418-6ralcn8p	62	1	[	[	-LRB-
cord-012418-6ralcn8p	62	2	33	33	CD
cord-012418-6ralcn8p	62	3	]	]	-RRB-
cord-012418-6ralcn8p	62	4	[	[	-LRB-
cord-012418-6ralcn8p	62	5	34	34	CD
cord-012418-6ralcn8p	62	6	]	]	-RRB-
cord-012418-6ralcn8p	62	7	.	.	.
cord-012418-6ralcn8p	63	1	Knockout	knockout	NN
cord-012418-6ralcn8p	63	2	experiments	experiment	NNS
cord-012418-6ralcn8p	63	3	in	in	IN
cord-012418-6ralcn8p	63	4	mice	mouse	NNS
cord-012418-6ralcn8p	63	5	have	have	VBP
cord-012418-6ralcn8p	63	6	shown	show	VBN
cord-012418-6ralcn8p	63	7	that	that	DT
cord-012418-6ralcn8p	63	8	lack	lack	NN
cord-012418-6ralcn8p	63	9	of	of	IN
cord-012418-6ralcn8p	63	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	63	11	delays	delay	VBZ
cord-012418-6ralcn8p	63	12	the	the	DT
cord-012418-6ralcn8p	63	13	immune	immune	JJ
cord-012418-6ralcn8p	63	14	response	response	NN
cord-012418-6ralcn8p	63	15	,	,	,
cord-012418-6ralcn8p	63	16	while	while	IN
cord-012418-6ralcn8p	63	17	cells	cell	NNS
cord-012418-6ralcn8p	63	18	lacking	lack	VBG
cord-012418-6ralcn8p	63	19	IRF7	IRF7	NNP
cord-012418-6ralcn8p	63	20	respond	respond	NNS
cord-012418-6ralcn8p	63	21	early	early	RB
cord-012418-6ralcn8p	63	22	but	but	CC
cord-012418-6ralcn8p	63	23	are	be	VBP
cord-012418-6ralcn8p	63	24	unable	unable	JJ
cord-012418-6ralcn8p	63	25	to	to	TO
cord-012418-6ralcn8p	63	26	fend	fend	VB
cord-012418-6ralcn8p	63	27	off	off	RP
cord-012418-6ralcn8p	63	28	the	the	DT
cord-012418-6ralcn8p	63	29	infection	infection	NN
cord-012418-6ralcn8p	63	30	without	without	IN
cord-012418-6ralcn8p	63	31	the	the	DT
cord-012418-6ralcn8p	63	32	signal	signal	NN
cord-012418-6ralcn8p	63	33	amplification	amplification	NN
cord-012418-6ralcn8p	63	34	[	[	-LRB-
cord-012418-6ralcn8p	63	35	27	27	CD
cord-012418-6ralcn8p	63	36	]	]	-RRB-
cord-012418-6ralcn8p	63	37	.	.	.
cord-012418-6ralcn8p	64	1	Accordingly	accordingly	RB
cord-012418-6ralcn8p	64	2	,	,	,
cord-012418-6ralcn8p	64	3	together	together	RB
cord-012418-6ralcn8p	64	4	with	with	IN
cord-012418-6ralcn8p	64	5	the	the	DT
cord-012418-6ralcn8p	64	6	hefty	hefty	JJ
cord-012418-6ralcn8p	64	7	feed	feed	VB
cord-012418-6ralcn8p	64	8	-	-	HYPH
cord-012418-6ralcn8p	64	9	forward	forward	RP
cord-012418-6ralcn8p	64	10	amplification	amplification	NN
cord-012418-6ralcn8p	64	11	of	of	IN
cord-012418-6ralcn8p	64	12	IFNα	IFNα	NNP
cord-012418-6ralcn8p	64	13	/	/	SYM
cord-012418-6ralcn8p	64	14	β	β	NN
cord-012418-6ralcn8p	64	15	signalling	signal	VBG
cord-012418-6ralcn8p	64	16	,	,	,
cord-012418-6ralcn8p	64	17	this	this	DT
cord-012418-6ralcn8p	64	18	feature	feature	NN
cord-012418-6ralcn8p	64	19	is	be	VBZ
cord-012418-6ralcn8p	64	20	essential	essential	JJ
cord-012418-6ralcn8p	64	21	for	for	IN
cord-012418-6ralcn8p	64	22	the	the	DT
cord-012418-6ralcn8p	64	23	induction	induction	NN
cord-012418-6ralcn8p	64	24	of	of	IN
cord-012418-6ralcn8p	64	25	distinct	distinct	JJ
cord-012418-6ralcn8p	64	26	and	and	CC
cord-012418-6ralcn8p	64	27	diverse	diverse	JJ
cord-012418-6ralcn8p	64	28	cytokine	cytokine	JJ
cord-012418-6ralcn8p	64	29	subsets	subset	NNS
cord-012418-6ralcn8p	64	30	by	by	IN
cord-012418-6ralcn8p	64	31	IRF7	IRF7	NNP
cord-012418-6ralcn8p	64	32	,	,	,
cord-012418-6ralcn8p	64	33	especially	especially	RB
cord-012418-6ralcn8p	64	34	of	of	IN
cord-012418-6ralcn8p	64	35	IFNα	IFNα	NNP
cord-012418-6ralcn8p	64	36	,	,	,
cord-012418-6ralcn8p	64	37	that	that	WDT
cord-012418-6ralcn8p	64	38	differentiate	differentiate	VBP
cord-012418-6ralcn8p	64	39	the	the	DT
cord-012418-6ralcn8p	64	40	reaction	reaction	NN
cord-012418-6ralcn8p	64	41	and	and	CC
cord-012418-6ralcn8p	64	42	prime	prime	JJ
cord-012418-6ralcn8p	64	43	cellular	cellular	JJ
cord-012418-6ralcn8p	64	44	immunity	immunity	NN
cord-012418-6ralcn8p	64	45	[	[	-LRB-
cord-012418-6ralcn8p	64	46	28	28	CD
cord-012418-6ralcn8p	64	47	,	,	,
cord-012418-6ralcn8p	64	48	35	35	CD
cord-012418-6ralcn8p	64	49	]	]	-RRB-
cord-012418-6ralcn8p	64	50	.	.	.
cord-012418-6ralcn8p	65	1	For	for	IN
cord-012418-6ralcn8p	65	2	this	this	DT
cord-012418-6ralcn8p	65	3	reason	reason	NN
cord-012418-6ralcn8p	65	4	,	,	,
cord-012418-6ralcn8p	65	5	Viruses	virus	NNS
cord-012418-6ralcn8p	65	6	2020	2020	CD
cord-012418-6ralcn8p	65	7	,	,	,
cord-012418-6ralcn8p	65	8	12	12	CD
cord-012418-6ralcn8p	65	9	,	,	,
cord-012418-6ralcn8p	65	10	733	733	CD
cord-012418-6ralcn8p	65	11	4	4	CD
cord-012418-6ralcn8p	65	12	of	of	IN
cord-012418-6ralcn8p	65	13	33	33	CD
cord-012418-6ralcn8p	65	14	both	both	CC
cord-012418-6ralcn8p	65	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	65	16	and	and	CC
cord-012418-6ralcn8p	65	17	IRF7	IRF7	NNP
cord-012418-6ralcn8p	65	18	are	be	VBP
cord-012418-6ralcn8p	65	19	crucial	crucial	JJ
cord-012418-6ralcn8p	65	20	for	for	IN
cord-012418-6ralcn8p	65	21	the	the	DT
cord-012418-6ralcn8p	65	22	rapid	rapid	JJ
cord-012418-6ralcn8p	65	23	induction	induction	NN
cord-012418-6ralcn8p	65	24	and	and	CC
cord-012418-6ralcn8p	65	25	potent	potent	JJ
cord-012418-6ralcn8p	65	26	establishment	establishment	NN
cord-012418-6ralcn8p	65	27	of	of	IN
cord-012418-6ralcn8p	65	28	the	the	DT
cord-012418-6ralcn8p	65	29	antiviral	antiviral	JJ
cord-012418-6ralcn8p	65	30	response	response	NN
cord-012418-6ralcn8p	65	31	[	[	-LRB-
cord-012418-6ralcn8p	65	32	27	27	CD
cord-012418-6ralcn8p	65	33	,	,	,
cord-012418-6ralcn8p	65	34	34	34	CD
cord-012418-6ralcn8p	65	35	]	]	-RRB-
cord-012418-6ralcn8p	65	36	.	.	.
cord-012418-6ralcn8p	66	1	The	the	DT
cord-012418-6ralcn8p	66	2	crucial	crucial	JJ
cord-012418-6ralcn8p	66	3	role	role	NN
cord-012418-6ralcn8p	66	4	of	of	IN
cord-012418-6ralcn8p	66	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	66	6	and	and	CC
cord-012418-6ralcn8p	66	7	the	the	DT
cord-012418-6ralcn8p	66	8	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	66	9	changes	change	NNS
cord-012418-6ralcn8p	66	10	it	-PRON-	PRP
cord-012418-6ralcn8p	66	11	undergoes	undergo	VBZ
cord-012418-6ralcn8p	66	12	upon	upon	IN
cord-012418-6ralcn8p	66	13	viral	viral	JJ
cord-012418-6ralcn8p	66	14	infection	infection	NN
cord-012418-6ralcn8p	66	15	were	be	VBD
cord-012418-6ralcn8p	66	16	first	first	RB
cord-012418-6ralcn8p	66	17	reported	report	VBN
cord-012418-6ralcn8p	66	18	more	more	JJR
cord-012418-6ralcn8p	66	19	than	than	IN
cord-012418-6ralcn8p	66	20	20	20	CD
cord-012418-6ralcn8p	66	21	years	year	NNS
cord-012418-6ralcn8p	66	22	ago	ago	RB
cord-012418-6ralcn8p	66	23	:	:	:
cord-012418-6ralcn8p	66	24	Upon	upon	IN
cord-012418-6ralcn8p	66	25	stimulation	stimulation	NN
cord-012418-6ralcn8p	66	26	,	,	,
cord-012418-6ralcn8p	66	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	66	28	gets	get	VBZ
cord-012418-6ralcn8p	66	29	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	66	30	and	and	CC
cord-012418-6ralcn8p	66	31	accumulates	accumulate	VBZ
cord-012418-6ralcn8p	66	32	in	in	IN
cord-012418-6ralcn8p	66	33	the	the	DT
cord-012418-6ralcn8p	66	34	nucleus	nucleus	NN
cord-012418-6ralcn8p	66	35	where	where	WRB
cord-012418-6ralcn8p	66	36	it	-PRON-	PRP
cord-012418-6ralcn8p	66	37	interacts	interact	VBZ
cord-012418-6ralcn8p	66	38	with	with	IN
cord-012418-6ralcn8p	66	39	the	the	DT
cord-012418-6ralcn8p	66	40	coactivators	coactivators	NNP
cord-012418-6ralcn8p	66	41	CREB	CREB	NNP
cord-012418-6ralcn8p	66	42	-	-	HYPH
cord-012418-6ralcn8p	66	43	binding	bind	VBG
cord-012418-6ralcn8p	66	44	protein	protein	NN
cord-012418-6ralcn8p	66	45	(	(	-LRB-
cord-012418-6ralcn8p	66	46	CBP)/p300	CBP)/p300	NNP
cord-012418-6ralcn8p	66	47	to	to	TO
cord-012418-6ralcn8p	66	48	specifically	specifically	RB
cord-012418-6ralcn8p	66	49	bind	bind	VB
cord-012418-6ralcn8p	66	50	to	to	IN
cord-012418-6ralcn8p	66	51	virus	virus	NN
cord-012418-6ralcn8p	66	52	-	-	HYPH
cord-012418-6ralcn8p	66	53	inducible	inducible	JJ
cord-012418-6ralcn8p	66	54	enhancer	enhancer	NN
cord-012418-6ralcn8p	66	55	elements	element	NNS
cord-012418-6ralcn8p	66	56	and	and	CC
cord-012418-6ralcn8p	66	57	exerts	exert	VBZ
cord-012418-6ralcn8p	66	58	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	66	59	activation	activation	NN
cord-012418-6ralcn8p	66	60	of	of	IN
cord-012418-6ralcn8p	66	61	the	the	DT
cord-012418-6ralcn8p	66	62	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	66	63	gene	gene	NN
cord-012418-6ralcn8p	66	64	[	[	-LRB-
cord-012418-6ralcn8p	66	65	21	21	CD
cord-012418-6ralcn8p	66	66	,	,	,
cord-012418-6ralcn8p	66	67	[	[	-LRB-
cord-012418-6ralcn8p	66	68	36	36	CD
cord-012418-6ralcn8p	66	69	]	]	-RRB-
cord-012418-6ralcn8p	67	1	[	[	-LRB-
cord-012418-6ralcn8p	67	2	37	37	CD
cord-012418-6ralcn8p	67	3	]	]	-RRB-
cord-012418-6ralcn8p	68	1	[	[	-LRB-
cord-012418-6ralcn8p	68	2	38	38	CD
cord-012418-6ralcn8p	68	3	]	]	-RRB-
cord-012418-6ralcn8p	69	1	(	(	-LRB-
cord-012418-6ralcn8p	69	2	Figure	figure	NN
cord-012418-6ralcn8p	69	3	2	2	CD
cord-012418-6ralcn8p	69	4	)	)	-RRB-
cord-012418-6ralcn8p	69	5	.	.	.
cord-012418-6ralcn8p	70	1	Since	since	IN
cord-012418-6ralcn8p	70	2	these	these	DT
cord-012418-6ralcn8p	70	3	first	first	JJ
cord-012418-6ralcn8p	70	4	observations	observation	NNS
cord-012418-6ralcn8p	70	5	,	,	,
cord-012418-6ralcn8p	70	6	our	-PRON-	PRP$
cord-012418-6ralcn8p	70	7	knowledge	knowledge	NN
cord-012418-6ralcn8p	70	8	of	of	IN
cord-012418-6ralcn8p	70	9	the	the	DT
cord-012418-6ralcn8p	70	10	mechanism	mechanism	NN
cord-012418-6ralcn8p	70	11	of	of	IN
cord-012418-6ralcn8p	70	12	action	action	NN
cord-012418-6ralcn8p	70	13	of	of	IN
cord-012418-6ralcn8p	70	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	70	15	has	have	VBZ
cord-012418-6ralcn8p	70	16	been	be	VBN
cord-012418-6ralcn8p	70	17	greatly	greatly	RB
cord-012418-6ralcn8p	70	18	refined	refine	VBN
cord-012418-6ralcn8p	70	19	.	.	.
cord-012418-6ralcn8p	71	1	Viruses	virus	NNS
cord-012418-6ralcn8p	71	2	2020	2020	CD
cord-012418-6ralcn8p	71	3	,	,	,
cord-012418-6ralcn8p	71	4	12	12	CD
cord-012418-6ralcn8p	71	5	,	,	,
cord-012418-6ralcn8p	71	6	x	x	NN
cord-012418-6ralcn8p	72	1	FOR	for	IN
cord-012418-6ralcn8p	72	2	PEER	peer	NN
cord-012418-6ralcn8p	72	3	REVIEW	REVIEW	NNP
cord-012418-6ralcn8p	72	4	4	4	CD
cord-012418-6ralcn8p	72	5	of	of	IN
cord-012418-6ralcn8p	72	6	33	33	CD
cord-012418-6ralcn8p	72	7	of	of	IN
cord-012418-6ralcn8p	72	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	72	9	delays	delay	NNS
cord-012418-6ralcn8p	72	10	the	the	DT
cord-012418-6ralcn8p	72	11	immune	immune	JJ
cord-012418-6ralcn8p	72	12	response	response	NN
cord-012418-6ralcn8p	72	13	,	,	,
cord-012418-6ralcn8p	72	14	while	while	IN
cord-012418-6ralcn8p	72	15	cells	cell	NNS
cord-012418-6ralcn8p	72	16	lacking	lack	VBG
cord-012418-6ralcn8p	72	17	IRF7	IRF7	NNP
cord-012418-6ralcn8p	72	18	respond	respond	NNS
cord-012418-6ralcn8p	72	19	early	early	RB
cord-012418-6ralcn8p	72	20	but	but	CC
cord-012418-6ralcn8p	72	21	are	be	VBP
cord-012418-6ralcn8p	72	22	unable	unable	JJ
cord-012418-6ralcn8p	72	23	to	to	TO
cord-012418-6ralcn8p	72	24	fend	fend	VB
cord-012418-6ralcn8p	72	25	off	off	RP
cord-012418-6ralcn8p	72	26	the	the	DT
cord-012418-6ralcn8p	72	27	infection	infection	NN
cord-012418-6ralcn8p	72	28	without	without	IN
cord-012418-6ralcn8p	72	29	the	the	DT
cord-012418-6ralcn8p	72	30	signal	signal	NN
cord-012418-6ralcn8p	72	31	amplification	amplification	NN
cord-012418-6ralcn8p	72	32	[	[	-LRB-
cord-012418-6ralcn8p	72	33	27	27	CD
cord-012418-6ralcn8p	72	34	]	]	-RRB-
cord-012418-6ralcn8p	72	35	.	.	.
cord-012418-6ralcn8p	73	1	Accordingly	accordingly	RB
cord-012418-6ralcn8p	73	2	,	,	,
cord-012418-6ralcn8p	73	3	together	together	RB
cord-012418-6ralcn8p	73	4	with	with	IN
cord-012418-6ralcn8p	73	5	the	the	DT
cord-012418-6ralcn8p	73	6	hefty	hefty	JJ
cord-012418-6ralcn8p	73	7	feed	feed	VB
cord-012418-6ralcn8p	73	8	-	-	HYPH
cord-012418-6ralcn8p	73	9	forward	forward	RP
cord-012418-6ralcn8p	73	10	amplification	amplification	NN
cord-012418-6ralcn8p	73	11	of	of	IN
cord-012418-6ralcn8p	73	12	IFNα	IFNα	NNP
cord-012418-6ralcn8p	73	13	/	/	SYM
cord-012418-6ralcn8p	73	14	β	β	NN
cord-012418-6ralcn8p	73	15	signalling	signal	VBG
cord-012418-6ralcn8p	73	16	,	,	,
cord-012418-6ralcn8p	73	17	this	this	DT
cord-012418-6ralcn8p	73	18	feature	feature	NN
cord-012418-6ralcn8p	73	19	is	be	VBZ
cord-012418-6ralcn8p	73	20	essential	essential	JJ
cord-012418-6ralcn8p	73	21	for	for	IN
cord-012418-6ralcn8p	73	22	the	the	DT
cord-012418-6ralcn8p	73	23	induction	induction	NN
cord-012418-6ralcn8p	73	24	of	of	IN
cord-012418-6ralcn8p	73	25	distinct	distinct	JJ
cord-012418-6ralcn8p	73	26	and	and	CC
cord-012418-6ralcn8p	73	27	diverse	diverse	JJ
cord-012418-6ralcn8p	73	28	cytokine	cytokine	JJ
cord-012418-6ralcn8p	73	29	subsets	subset	NNS
cord-012418-6ralcn8p	73	30	by	by	IN
cord-012418-6ralcn8p	73	31	IRF7	IRF7	NNP
cord-012418-6ralcn8p	73	32	,	,	,
cord-012418-6ralcn8p	73	33	especially	especially	RB
cord-012418-6ralcn8p	73	34	of	of	IN
cord-012418-6ralcn8p	73	35	IFNα	IFNα	NNP
cord-012418-6ralcn8p	73	36	,	,	,
cord-012418-6ralcn8p	73	37	that	that	WDT
cord-012418-6ralcn8p	73	38	differentiate	differentiate	VBP
cord-012418-6ralcn8p	73	39	the	the	DT
cord-012418-6ralcn8p	73	40	reaction	reaction	NN
cord-012418-6ralcn8p	73	41	and	and	CC
cord-012418-6ralcn8p	73	42	prime	prime	JJ
cord-012418-6ralcn8p	73	43	cellular	cellular	JJ
cord-012418-6ralcn8p	73	44	immunity	immunity	NN
cord-012418-6ralcn8p	73	45	[	[	-LRB-
cord-012418-6ralcn8p	73	46	28	28	CD
cord-012418-6ralcn8p	73	47	,	,	,
cord-012418-6ralcn8p	73	48	35	35	CD
cord-012418-6ralcn8p	73	49	]	]	-RRB-
cord-012418-6ralcn8p	73	50	.	.	.
cord-012418-6ralcn8p	74	1	For	for	IN
cord-012418-6ralcn8p	74	2	this	this	DT
cord-012418-6ralcn8p	74	3	reason	reason	NN
cord-012418-6ralcn8p	74	4	,	,	,
cord-012418-6ralcn8p	74	5	both	both	CC
cord-012418-6ralcn8p	74	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	74	7	and	and	CC
cord-012418-6ralcn8p	74	8	IRF7	IRF7	NNP
cord-012418-6ralcn8p	74	9	are	be	VBP
cord-012418-6ralcn8p	74	10	crucial	crucial	JJ
cord-012418-6ralcn8p	74	11	for	for	IN
cord-012418-6ralcn8p	74	12	the	the	DT
cord-012418-6ralcn8p	74	13	rapid	rapid	JJ
cord-012418-6ralcn8p	74	14	induction	induction	NN
cord-012418-6ralcn8p	74	15	and	and	CC
cord-012418-6ralcn8p	74	16	potent	potent	JJ
cord-012418-6ralcn8p	74	17	establishment	establishment	NN
cord-012418-6ralcn8p	74	18	of	of	IN
cord-012418-6ralcn8p	74	19	the	the	DT
cord-012418-6ralcn8p	74	20	antiviral	antiviral	JJ
cord-012418-6ralcn8p	74	21	response	response	NN
cord-012418-6ralcn8p	74	22	[	[	-LRB-
cord-012418-6ralcn8p	74	23	27	27	CD
cord-012418-6ralcn8p	74	24	,	,	,
cord-012418-6ralcn8p	74	25	34	34	CD
cord-012418-6ralcn8p	74	26	]	]	-RRB-
cord-012418-6ralcn8p	74	27	.	.	.
cord-012418-6ralcn8p	75	1	The	the	DT
cord-012418-6ralcn8p	75	2	crucial	crucial	JJ
cord-012418-6ralcn8p	75	3	role	role	NN
cord-012418-6ralcn8p	75	4	of	of	IN
cord-012418-6ralcn8p	75	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	75	6	and	and	CC
cord-012418-6ralcn8p	75	7	the	the	DT
cord-012418-6ralcn8p	75	8	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	75	9	changes	change	NNS
cord-012418-6ralcn8p	75	10	it	-PRON-	PRP
cord-012418-6ralcn8p	75	11	undergoes	undergo	VBZ
cord-012418-6ralcn8p	75	12	upon	upon	IN
cord-012418-6ralcn8p	75	13	viral	viral	JJ
cord-012418-6ralcn8p	75	14	infection	infection	NN
cord-012418-6ralcn8p	75	15	were	be	VBD
cord-012418-6ralcn8p	75	16	first	first	RB
cord-012418-6ralcn8p	75	17	reported	report	VBN
cord-012418-6ralcn8p	75	18	more	more	JJR
cord-012418-6ralcn8p	75	19	than	than	IN
cord-012418-6ralcn8p	75	20	20	20	CD
cord-012418-6ralcn8p	75	21	years	year	NNS
cord-012418-6ralcn8p	75	22	ago	ago	RB
cord-012418-6ralcn8p	75	23	:	:	:
cord-012418-6ralcn8p	75	24	Upon	upon	IN
cord-012418-6ralcn8p	75	25	stimulation	stimulation	NN
cord-012418-6ralcn8p	75	26	,	,	,
cord-012418-6ralcn8p	75	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	75	28	gets	get	VBZ
cord-012418-6ralcn8p	75	29	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	75	30	and	and	CC
cord-012418-6ralcn8p	75	31	accumulates	accumulate	VBZ
cord-012418-6ralcn8p	75	32	in	in	IN
cord-012418-6ralcn8p	75	33	the	the	DT
cord-012418-6ralcn8p	75	34	nucleus	nucleus	NN
cord-012418-6ralcn8p	75	35	where	where	WRB
cord-012418-6ralcn8p	75	36	it	-PRON-	PRP
cord-012418-6ralcn8p	75	37	interacts	interact	VBZ
cord-012418-6ralcn8p	75	38	with	with	IN
cord-012418-6ralcn8p	75	39	the	the	DT
cord-012418-6ralcn8p	75	40	coactivators	coactivators	NNP
cord-012418-6ralcn8p	75	41	CREB	CREB	NNP
cord-012418-6ralcn8p	75	42	-	-	HYPH
cord-012418-6ralcn8p	75	43	binding	bind	VBG
cord-012418-6ralcn8p	75	44	protein	protein	NN
cord-012418-6ralcn8p	75	45	(	(	-LRB-
cord-012418-6ralcn8p	75	46	CBP)/p300	CBP)/p300	NNP
cord-012418-6ralcn8p	75	47	to	to	TO
cord-012418-6ralcn8p	75	48	specifically	specifically	RB
cord-012418-6ralcn8p	75	49	bind	bind	VB
cord-012418-6ralcn8p	75	50	to	to	IN
cord-012418-6ralcn8p	75	51	virus	virus	NN
cord-012418-6ralcn8p	75	52	-	-	HYPH
cord-012418-6ralcn8p	75	53	inducible	inducible	JJ
cord-012418-6ralcn8p	75	54	enhancer	enhancer	NN
cord-012418-6ralcn8p	75	55	elements	element	NNS
cord-012418-6ralcn8p	75	56	and	and	CC
cord-012418-6ralcn8p	75	57	exerts	exert	VBZ
cord-012418-6ralcn8p	75	58	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	75	59	activation	activation	NN
cord-012418-6ralcn8p	75	60	of	of	IN
cord-012418-6ralcn8p	75	61	the	the	DT
cord-012418-6ralcn8p	75	62	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	75	63	gene	gene	NN
cord-012418-6ralcn8p	75	64	[	[	-LRB-
cord-012418-6ralcn8p	75	65	21	21	CD
cord-012418-6ralcn8p	75	66	,	,	,
cord-012418-6ralcn8p	75	67	[	[	-LRB-
cord-012418-6ralcn8p	75	68	36	36	CD
cord-012418-6ralcn8p	75	69	]	]	-RRB-
cord-012418-6ralcn8p	76	1	[	[	-LRB-
cord-012418-6ralcn8p	76	2	37	37	CD
cord-012418-6ralcn8p	76	3	]	]	-RRB-
cord-012418-6ralcn8p	77	1	[	[	-LRB-
cord-012418-6ralcn8p	77	2	38	38	CD
cord-012418-6ralcn8p	77	3	]	]	-RRB-
cord-012418-6ralcn8p	78	1	(	(	-LRB-
cord-012418-6ralcn8p	78	2	Figure	figure	NN
cord-012418-6ralcn8p	78	3	2	2	CD
cord-012418-6ralcn8p	78	4	)	)	-RRB-
cord-012418-6ralcn8p	78	5	.	.	.
cord-012418-6ralcn8p	79	1	Since	since	IN
cord-012418-6ralcn8p	79	2	these	these	DT
cord-012418-6ralcn8p	79	3	first	first	JJ
cord-012418-6ralcn8p	79	4	observations	observation	NNS
cord-012418-6ralcn8p	79	5	,	,	,
cord-012418-6ralcn8p	79	6	our	-PRON-	PRP$
cord-012418-6ralcn8p	79	7	knowledge	knowledge	NN
cord-012418-6ralcn8p	79	8	of	of	IN
cord-012418-6ralcn8p	79	9	the	the	DT
cord-012418-6ralcn8p	79	10	mechanism	mechanism	NN
cord-012418-6ralcn8p	79	11	of	of	IN
cord-012418-6ralcn8p	79	12	action	action	NN
cord-012418-6ralcn8p	79	13	of	of	IN
cord-012418-6ralcn8p	79	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	79	15	has	have	VBZ
cord-012418-6ralcn8p	79	16	been	be	VBN
cord-012418-6ralcn8p	79	17	greatly	greatly	RB
cord-012418-6ralcn8p	79	18	refined	refine	VBN
cord-012418-6ralcn8p	79	19	.	.	.
cord-012418-6ralcn8p	80	1	by	by	IN
cord-012418-6ralcn8p	80	2	RNA	RNA	NNP
cord-012418-6ralcn8p	80	3	or	or	CC
cord-012418-6ralcn8p	80	4	DNA	DNA	NNP
cord-012418-6ralcn8p	80	5	sensors	sensor	NNS
cord-012418-6ralcn8p	80	6	in	in	IN
cord-012418-6ralcn8p	80	7	the	the	DT
cord-012418-6ralcn8p	80	8	cytosol	cytosol	NN
cord-012418-6ralcn8p	80	9	.	.	.
cord-012418-6ralcn8p	81	1	Activation	activation	NN
cord-012418-6ralcn8p	81	2	of	of	IN
cord-012418-6ralcn8p	81	3	retinoic	retinoic	JJ
cord-012418-6ralcn8p	81	4	acid	acid	NN
cord-012418-6ralcn8p	81	5	-	-	HYPH
cord-012418-6ralcn8p	81	6	inducible	inducible	JJ
cord-012418-6ralcn8p	81	7	gene	gene	NN
cord-012418-6ralcn8p	82	1	I	-PRON-	PRP
cord-012418-6ralcn8p	82	2	(	(	-LRB-
cord-012418-6ralcn8p	82	3	RIG	RIG	NNP
cord-012418-6ralcn8p	82	4	-	-	HYPH
cord-012418-6ralcn8p	82	5	I)-like	I)-like	NNP
cord-012418-6ralcn8p	82	6	receptors	receptor	NNS
cord-012418-6ralcn8p	82	7	(	(	-LRB-
cord-012418-6ralcn8p	82	8	RLRs	rlr	NNS
cord-012418-6ralcn8p	82	9	)	)	-RRB-
cord-012418-6ralcn8p	82	10	like	like	IN
cord-012418-6ralcn8p	82	11	RIG	rig	NN
cord-012418-6ralcn8p	83	1	-I	-i	WDT
cord-012418-6ralcn8p	83	2	induces	induce	VBZ
cord-012418-6ralcn8p	83	3	aggregation	aggregation	NN
cord-012418-6ralcn8p	83	4	of	of	IN
cord-012418-6ralcn8p	83	5	the	the	DT
cord-012418-6ralcn8p	83	6	mitochondrial	mitochondrial	JJ
cord-012418-6ralcn8p	83	7	adaptor	adaptor	NN
cord-012418-6ralcn8p	83	8	protein	protein	NN
cord-012418-6ralcn8p	83	9	mitochondrial	mitochondrial	NN
cord-012418-6ralcn8p	83	10	antiviral	antiviral	JJ
cord-012418-6ralcn8p	83	11	signalling	signal	VBG
cord-012418-6ralcn8p	83	12	protein	protein	NN
cord-012418-6ralcn8p	83	13	(	(	-LRB-
cord-012418-6ralcn8p	83	14	MAVS	MAVS	NNP
cord-012418-6ralcn8p	83	15	)	)	-RRB-
cord-012418-6ralcn8p	83	16	.	.	.
cord-012418-6ralcn8p	84	1	Detection	detection	NN
cord-012418-6ralcn8p	84	2	of	of	IN
cord-012418-6ralcn8p	84	3	DNA	dna	NN
cord-012418-6ralcn8p	84	4	by	by	IN
cord-012418-6ralcn8p	84	5	the	the	DT
cord-012418-6ralcn8p	84	6	DNA	dna	NN
cord-012418-6ralcn8p	84	7	sensor	sensor	NN
cord-012418-6ralcn8p	85	1	cyclic	cyclic	JJ
cord-012418-6ralcn8p	85	2	GMP	GMP	NNP
cord-012418-6ralcn8p	85	3	-	-	HYPH
cord-012418-6ralcn8p	85	4	AMP	AMP	NNP
cord-012418-6ralcn8p	85	5	(	(	-LRB-
cord-012418-6ralcn8p	85	6	cGAMP	cGAMP	NNP
cord-012418-6ralcn8p	85	7	)	)	-RRB-
cord-012418-6ralcn8p	85	8	synthase	synthase	NN
cord-012418-6ralcn8p	85	9	(	(	-LRB-
cord-012418-6ralcn8p	85	10	cGAS	cgas	NN
cord-012418-6ralcn8p	85	11	)	)	-RRB-
cord-012418-6ralcn8p	85	12	activates	activate	VBZ
cord-012418-6ralcn8p	85	13	production	production	NN
cord-012418-6ralcn8p	85	14	of	of	IN
cord-012418-6ralcn8p	85	15	the	the	DT
cord-012418-6ralcn8p	85	16	second	second	JJ
cord-012418-6ralcn8p	85	17	messenger	messenger	NN
cord-012418-6ralcn8p	85	18	cGAMP	cGAMP	NNP
cord-012418-6ralcn8p	85	19	,	,	,
cord-012418-6ralcn8p	85	20	which	which	WDT
cord-012418-6ralcn8p	85	21	in	in	IN
cord-012418-6ralcn8p	85	22	turn	turn	NN
cord-012418-6ralcn8p	85	23	induces	induce	VBZ
cord-012418-6ralcn8p	85	24	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	85	25	of	of	IN
cord-012418-6ralcn8p	85	26	the	the	DT
cord-012418-6ralcn8p	85	27	adaptor	adaptor	NN
cord-012418-6ralcn8p	85	28	protein	protein	NN
cord-012418-6ralcn8p	85	29	stimulator	stimulator	NN
cord-012418-6ralcn8p	85	30	of	of	IN
cord-012418-6ralcn8p	85	31	interferon	interferon	NN
cord-012418-6ralcn8p	85	32	genes	gene	NNS
cord-012418-6ralcn8p	85	33	(	(	-LRB-
cord-012418-6ralcn8p	85	34	STING	sting	VB
cord-012418-6ralcn8p	85	35	)	)	-RRB-
cord-012418-6ralcn8p	85	36	and	and	CC
cord-012418-6ralcn8p	85	37	its	-PRON-	PRP$
cord-012418-6ralcn8p	85	38	translocation	translocation	NN
cord-012418-6ralcn8p	85	39	from	from	IN
cord-012418-6ralcn8p	85	40	the	the	DT
cord-012418-6ralcn8p	85	41	endoplasmic	endoplasmic	NN
cord-012418-6ralcn8p	85	42	reticulum	reticulum	NN
cord-012418-6ralcn8p	85	43	(	(	-LRB-
cord-012418-6ralcn8p	85	44	ER	ER	NNP
cord-012418-6ralcn8p	85	45	)	)	-RRB-
cord-012418-6ralcn8p	85	46	to	to	IN
cord-012418-6ralcn8p	85	47	the	the	DT
cord-012418-6ralcn8p	85	48	Golgi	Golgi	NNP
cord-012418-6ralcn8p	85	49	apparatus	apparatus	NN
cord-012418-6ralcn8p	85	50	.	.	.
cord-012418-6ralcn8p	86	1	Higher	high	JJR
cord-012418-6ralcn8p	86	2	-	-	HYPH
cord-012418-6ralcn8p	86	3	order	order	NN
cord-012418-6ralcn8p	86	4	structures	structure	NNS
cord-012418-6ralcn8p	86	5	of	of	IN
cord-012418-6ralcn8p	86	6	the	the	DT
cord-012418-6ralcn8p	86	7	adaptor	adaptor	NN
cord-012418-6ralcn8p	86	8	molecules	molecule	NNS
cord-012418-6ralcn8p	86	9	recruit	recruit	VBP
cord-012418-6ralcn8p	86	10	the	the	DT
cord-012418-6ralcn8p	86	11	kinase	kinase	NN
cord-012418-6ralcn8p	86	12	TANK	tank	NN
cord-012418-6ralcn8p	86	13	-	-	HYPH
cord-012418-6ralcn8p	86	14	binding	bind	VBG
cord-012418-6ralcn8p	86	15	kinase	kinase	NN
cord-012418-6ralcn8p	86	16	1	1	CD
cord-012418-6ralcn8p	86	17	(	(	-LRB-
cord-012418-6ralcn8p	86	18	TBK1	TBK1	NNP
cord-012418-6ralcn8p	86	19	)	)	-RRB-
cord-012418-6ralcn8p	86	20	which	which	WDT
cord-012418-6ralcn8p	86	21	leads	lead	VBZ
cord-012418-6ralcn8p	86	22	to	to	IN
cord-012418-6ralcn8p	86	23	their	-PRON-	PRP$
cord-012418-6ralcn8p	86	24	TBK1-mediated	tbk1-mediate	VBN
cord-012418-6ralcn8p	86	25	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	86	26	.	.	.
cord-012418-6ralcn8p	87	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	87	2	is	be	VBZ
cord-012418-6ralcn8p	87	3	recruited	recruit	VBN
cord-012418-6ralcn8p	87	4	to	to	IN
cord-012418-6ralcn8p	87	5	this	this	DT
cord-012418-6ralcn8p	87	6	platform	platform	NN
cord-012418-6ralcn8p	87	7	and	and	CC
cord-012418-6ralcn8p	87	8	gets	get	VBZ
cord-012418-6ralcn8p	87	9	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	87	10	by	by	IN
cord-012418-6ralcn8p	87	11	TBK1	TBK1	NNP
cord-012418-6ralcn8p	87	12	at	at	IN
cord-012418-6ralcn8p	87	13	key	key	JJ
cord-012418-6ralcn8p	87	14	residues	residue	NNS
cord-012418-6ralcn8p	87	15	in	in	IN
cord-012418-6ralcn8p	87	16	the	the	DT
cord-012418-6ralcn8p	87	17	AIE	aie	NN
cord-012418-6ralcn8p	87	18	,	,	,
cord-012418-6ralcn8p	87	19	relieving	relieve	VBG
cord-012418-6ralcn8p	87	20	the	the	DT
cord-012418-6ralcn8p	87	21	auto	auto	NN
cord-012418-6ralcn8p	87	22	-	-	HYPH
cord-012418-6ralcn8p	87	23	inhibition	inhibition	NN
cord-012418-6ralcn8p	87	24	.	.	.
cord-012418-6ralcn8p	88	1	Activated	Activated	NNP
cord-012418-6ralcn8p	88	2	IRF3	IRF3	NNP
cord-012418-6ralcn8p	88	3	heterodimerises	heterodimerise	NNS
cord-012418-6ralcn8p	88	4	and	and	CC
cord-012418-6ralcn8p	88	5	associates	associate	NNS
cord-012418-6ralcn8p	88	6	with	with	IN
cord-012418-6ralcn8p	88	7	the	the	DT
cord-012418-6ralcn8p	88	8	coactivators	coactivators	NNP
cord-012418-6ralcn8p	88	9	CBP	CBP	NNP
cord-012418-6ralcn8p	88	10	/	/	SYM
cord-012418-6ralcn8p	88	11	p300	p300	NN
cord-012418-6ralcn8p	88	12	after	after	IN
cord-012418-6ralcn8p	88	13	translocation	translocation	NN
cord-012418-6ralcn8p	88	14	into	into	IN
cord-012418-6ralcn8p	88	15	the	the	DT
cord-012418-6ralcn8p	88	16	nucleus	nucleus	NN
cord-012418-6ralcn8p	88	17	,	,	,
cord-012418-6ralcn8p	88	18	yielding	yield	VBG
cord-012418-6ralcn8p	88	19	a	a	DT
cord-012418-6ralcn8p	88	20	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	88	21	with	with	IN
cord-012418-6ralcn8p	88	22	trans	trans	JJ
cord-012418-6ralcn8p	88	23	-	-	NN
cord-012418-6ralcn8p	88	24	activation	activation	JJ
cord-012418-6ralcn8p	88	25	potential	potential	NN
cord-012418-6ralcn8p	88	26	.	.	.
cord-012418-6ralcn8p	89	1	In	in	IN
cord-012418-6ralcn8p	89	2	parallel	parallel	NN
cord-012418-6ralcn8p	89	3	,	,	,
cord-012418-6ralcn8p	89	4	the	the	DT
cord-012418-6ralcn8p	89	5	heterodimeric	heterodimeric	JJ
cord-012418-6ralcn8p	89	6	transcription	transcription	NN
cord-012418-6ralcn8p	89	7	factors	factor	NNS
cord-012418-6ralcn8p	89	8	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	89	9	(	(	-LRB-
cord-012418-6ralcn8p	89	10	NF	nf	NN
cord-012418-6ralcn8p	89	11	-	-	HYPH
cord-012418-6ralcn8p	89	12	κB	κB	NNP
cord-012418-6ralcn8p	89	13	)	)	-RRB-
cord-012418-6ralcn8p	89	14	and	and	CC
cord-012418-6ralcn8p	89	15	ATF2-c	ATF2-c	NNP
cord-012418-6ralcn8p	89	16	-	-	HYPH
cord-012418-6ralcn8p	89	17	Jun	Jun	NNP
cord-012418-6ralcn8p	89	18	(	(	-LRB-
cord-012418-6ralcn8p	89	19	AP-1	AP-1	NNP
cord-012418-6ralcn8p	89	20	)	)	-RRB-
cord-012418-6ralcn8p	89	21	are	be	VBP
cord-012418-6ralcn8p	89	22	activated	activate	VBN
cord-012418-6ralcn8p	89	23	and	and	CC
cord-012418-6ralcn8p	89	24	enter	enter	VB
cord-012418-6ralcn8p	89	25	the	the	DT
cord-012418-6ralcn8p	89	26	nucleus	nucleus	NN
cord-012418-6ralcn8p	89	27	.	.	.
cord-012418-6ralcn8p	90	1	First	first	RB
cord-012418-6ralcn8p	90	2	,	,	,
cord-012418-6ralcn8p	90	3	p50-p65	p50-p65	NNP
cord-012418-6ralcn8p	90	4	is	be	VBZ
cord-012418-6ralcn8p	90	5	recruited	recruit	VBN
cord-012418-6ralcn8p	90	6	to	to	IN
cord-012418-6ralcn8p	90	7	the	the	DT
cord-012418-6ralcn8p	90	8	enhancer	enhancer	NN
cord-012418-6ralcn8p	90	9	element	element	NN
cord-012418-6ralcn8p	90	10	upstream	upstream	RB
cord-012418-6ralcn8p	90	11	of	of	IN
cord-012418-6ralcn8p	90	12	the	the	DT
cord-012418-6ralcn8p	90	13	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	90	14	gene	gene	NN
cord-012418-6ralcn8p	90	15	,	,	,
cord-012418-6ralcn8p	90	16	followed	follow	VBN
cord-012418-6ralcn8p	90	17	by	by	IN
cord-012418-6ralcn8p	90	18	ATF2-c	ATF2-c	NNP
cord-012418-6ralcn8p	90	19	-	-	HYPH
cord-012418-6ralcn8p	90	20	Jun	Jun	NNP
cord-012418-6ralcn8p	90	21	and	and	CC
cord-012418-6ralcn8p	90	22	the	the	DT
cord-012418-6ralcn8p	90	23	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	90	24	/	/	SYM
cord-012418-6ralcn8p	90	25	p300	p300	NNP
cord-012418-6ralcn8p	90	26	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	90	27	.	.	.
cord-012418-6ralcn8p	91	1	The	the	DT
cord-012418-6ralcn8p	91	2	assembled	assembled	JJ
cord-012418-6ralcn8p	91	3	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	91	4	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	91	5	promotes	promote	VBZ
cord-012418-6ralcn8p	91	6	recruitment	recruitment	NN
cord-012418-6ralcn8p	91	7	of	of	IN
cord-012418-6ralcn8p	91	8	the	the	DT
cord-012418-6ralcn8p	91	9	basal	basal	NN
cord-012418-6ralcn8p	91	10	transcription	transcription	NN
cord-012418-6ralcn8p	91	11	machinery	machinery	NN
cord-012418-6ralcn8p	91	12	for	for	IN
cord-012418-6ralcn8p	91	13	the	the	DT
cord-012418-6ralcn8p	91	14	expression	expression	NN
cord-012418-6ralcn8p	91	15	of	of	IN
cord-012418-6ralcn8p	91	16	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	91	17	.	.	.
cord-012418-6ralcn8p	92	1	Hyperphosphorylation	Hyperphosphorylation	NNP
cord-012418-6ralcn8p	92	2	is	be	VBZ
cord-012418-6ralcn8p	92	3	the	the	DT
cord-012418-6ralcn8p	92	4	first	first	JJ
cord-012418-6ralcn8p	92	5	step	step	NN
cord-012418-6ralcn8p	92	6	in	in	IN
cord-012418-6ralcn8p	92	7	the	the	DT
cord-012418-6ralcn8p	92	8	activation	activation	NN
cord-012418-6ralcn8p	92	9	of	of	IN
cord-012418-6ralcn8p	92	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	92	11	as	as	IN
cord-012418-6ralcn8p	92	12	a	a	DT
cord-012418-6ralcn8p	92	13	functional	functional	JJ
cord-012418-6ralcn8p	92	14	transcription	transcription	NN
cord-012418-6ralcn8p	92	15	factor	factor	NN
cord-012418-6ralcn8p	92	16	.	.	.
cord-012418-6ralcn8p	93	1	In	in	IN
cord-012418-6ralcn8p	93	2	unstimulated	unstimulated	JJ
cord-012418-6ralcn8p	93	3	cells	cell	NNS
cord-012418-6ralcn8p	93	4	,	,	,
cord-012418-6ralcn8p	93	5	the	the	DT
cord-012418-6ralcn8p	93	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	93	7	protein	protein	NN
cord-012418-6ralcn8p	93	8	exists	exist	VBZ
cord-012418-6ralcn8p	93	9	as	as	IN
cord-012418-6ralcn8p	93	10	two	two	CD
cord-012418-6ralcn8p	93	11	forms	form	NNS
cord-012418-6ralcn8p	93	12	,	,	,
cord-012418-6ralcn8p	93	13	an	an	DT
cord-012418-6ralcn8p	93	14	unphosphorylated	unphosphorylated	NNP
cord-012418-6ralcn8p	93	15	(	(	-LRB-
cord-012418-6ralcn8p	93	16	I	i	NN
cord-012418-6ralcn8p	93	17	)	)	-RRB-
cord-012418-6ralcn8p	93	18	and	and	CC
cord-012418-6ralcn8p	93	19	a	a	DT
cord-012418-6ralcn8p	93	20	basally	basally	RB
cord-012418-6ralcn8p	93	21	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	93	22	(	(	-LRB-
cord-012418-6ralcn8p	93	23	II	ii	NN
cord-012418-6ralcn8p	93	24	)	)	-RRB-
cord-012418-6ralcn8p	93	25	form	form	NN
cord-012418-6ralcn8p	93	26	[	[	-LRB-
cord-012418-6ralcn8p	93	27	39	39	CD
cord-012418-6ralcn8p	93	28	]	]	-RRB-
cord-012418-6ralcn8p	93	29	.	.	.
cord-012418-6ralcn8p	94	1	After	after	IN
cord-012418-6ralcn8p	94	2	viral	viral	JJ
cord-012418-6ralcn8p	94	3	infection	infection	NN
cord-012418-6ralcn8p	94	4	,	,	,
cord-012418-6ralcn8p	94	5	IκB	iκb	NN
cord-012418-6ralcn8p	94	6	kinase	kinase	NN
cord-012418-6ralcn8p	94	7	-	-	HYPH
cord-012418-6ralcn8p	94	8	epsilon	epsilon	NN
cord-012418-6ralcn8p	94	9	(	(	-LRB-
cord-012418-6ralcn8p	94	10	IKKε	IKKε	NNP
cord-012418-6ralcn8p	94	11	)	)	-RRB-
cord-012418-6ralcn8p	94	12	and	and	CC
cord-012418-6ralcn8p	94	13	TANK	tank	NN
cord-012418-6ralcn8p	94	14	-	-	HYPH
cord-012418-6ralcn8p	94	15	binding	bind	VBG
cord-012418-6ralcn8p	94	16	kinase	kinase	NN
cord-012418-6ralcn8p	94	17	1	1	CD
cord-012418-6ralcn8p	94	18	(	(	-LRB-
cord-012418-6ralcn8p	94	19	TBK1	TBK1	NNP
cord-012418-6ralcn8p	94	20	)	)	-RRB-
cord-012418-6ralcn8p	94	21	,	,	,
cord-012418-6ralcn8p	94	22	two	two	CD
cord-012418-6ralcn8p	94	23	homologs	homolog	NNS
cord-012418-6ralcn8p	94	24	of	of	IN
cord-012418-6ralcn8p	94	25	the	the	DT
cord-012418-6ralcn8p	94	26	inhibitor	inhibitor	NN
cord-012418-6ralcn8p	94	27	of	of	IN
cord-012418-6ralcn8p	94	28	NF	NF	NNP
cord-012418-6ralcn8p	94	29	-	-	HYPH
cord-012418-6ralcn8p	94	30	κB	κB	NNP
cord-012418-6ralcn8p	94	31	kinase	kinase	NN
cord-012418-6ralcn8p	94	32	(	(	-LRB-
cord-012418-6ralcn8p	94	33	IKK	IKK	NNP
cord-012418-6ralcn8p	94	34	)	)	-RRB-
cord-012418-6ralcn8p	94	35	,	,	,
cord-012418-6ralcn8p	94	36	are	be	VBP
cord-012418-6ralcn8p	94	37	activated	activate	VBN
cord-012418-6ralcn8p	94	38	when	when	WRB
cord-012418-6ralcn8p	94	39	PRRs	prr	NNS
cord-012418-6ralcn8p	94	40	convey	convey	VBP
cord-012418-6ralcn8p	94	41	the	the	DT
cord-012418-6ralcn8p	94	42	sensing	sensing	NN
cord-012418-6ralcn8p	94	43	of	of	IN
cord-012418-6ralcn8p	94	44	virus	virus	NN
cord-012418-6ralcn8p	94	45	infection	infection	NN
cord-012418-6ralcn8p	94	46	to	to	IN
cord-012418-6ralcn8p	94	47	their	-PRON-	PRP$
cord-012418-6ralcn8p	94	48	adaptor	adaptor	NN
cord-012418-6ralcn8p	94	49	proteins	protein	NNS
cord-012418-6ralcn8p	94	50	,	,	,
cord-012418-6ralcn8p	94	51	inducing	induce	VBG
cord-012418-6ralcn8p	94	52	conformational	conformational	JJ
cord-012418-6ralcn8p	94	53	changes	change	NNS
cord-012418-6ralcn8p	94	54	and	and	CC
cord-012418-6ralcn8p	94	55	interactions	interaction	NNS
cord-012418-6ralcn8p	94	56	that	that	WDT
cord-012418-6ralcn8p	94	57	lead	lead	VBP
cord-012418-6ralcn8p	94	58	to	to	IN
cord-012418-6ralcn8p	94	59	the	the	DT
cord-012418-6ralcn8p	94	60	formation	formation	NN
cord-012418-6ralcn8p	94	61	of	of	IN
cord-012418-6ralcn8p	94	62	a	a	DT
cord-012418-6ralcn8p	94	63	new	new	JJ
cord-012418-6ralcn8p	94	64	interaction	interaction	NN
cord-012418-6ralcn8p	94	65	surface	surface	NN
cord-012418-6ralcn8p	94	66	(	(	-LRB-
cord-012418-6ralcn8p	94	67	reviewed	review	VBN
cord-012418-6ralcn8p	94	68	in	in	IN
cord-012418-6ralcn8p	94	69	[	[	-LRB-
cord-012418-6ralcn8p	94	70	13	13	CD
cord-012418-6ralcn8p	94	71	]	]	-RRB-
cord-012418-6ralcn8p	94	72	)	)	-RRB-
cord-012418-6ralcn8p	94	73	.	.	.
cord-012418-6ralcn8p	95	1	The	the	DT
cord-012418-6ralcn8p	95	2	kinase	kinase	NN
cord-012418-6ralcn8p	95	3	binds	bind	VBZ
cord-012418-6ralcn8p	95	4	to	to	IN
cord-012418-6ralcn8p	95	5	this	this	DT
cord-012418-6ralcn8p	95	6	signal	signal	NN
cord-012418-6ralcn8p	95	7	-	-	HYPH
cord-012418-6ralcn8p	95	8	induced	induce	VBN
cord-012418-6ralcn8p	95	9	adaptor	adaptor	NN
cord-012418-6ralcn8p	95	10	platform	platform	NN
cord-012418-6ralcn8p	95	11	and	and	CC
cord-012418-6ralcn8p	95	12	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	95	13	the	the	DT
cord-012418-6ralcn8p	95	14	pLxIS	plxis	JJ
cord-012418-6ralcn8p	95	15	motif	motif	NN
cord-012418-6ralcn8p	95	16	(	(	-LRB-
cord-012418-6ralcn8p	95	17	p	p	NN
cord-012418-6ralcn8p	95	18	:	:	:
cord-012418-6ralcn8p	95	19	hydrophilic	hydrophilic	JJ
cord-012418-6ralcn8p	95	20	,	,	,
cord-012418-6ralcn8p	96	1	x	x	LS
cord-012418-6ralcn8p	96	2	:	:	:
cord-012418-6ralcn8p	96	3	any	any	DT
cord-012418-6ralcn8p	96	4	AA	AA	NNP
cord-012418-6ralcn8p	96	5	)	)	-RRB-
cord-012418-6ralcn8p	96	6	on	on	IN
cord-012418-6ralcn8p	96	7	the	the	DT
cord-012418-6ralcn8p	96	8	surface	surface	NN
cord-012418-6ralcn8p	96	9	of	of	IN
cord-012418-6ralcn8p	96	10	the	the	DT
cord-012418-6ralcn8p	96	11	adaptor	adaptor	NN
cord-012418-6ralcn8p	96	12	proteins	protein	NNS
cord-012418-6ralcn8p	96	13	[	[	-LRB-
cord-012418-6ralcn8p	96	14	40	40	CD
cord-012418-6ralcn8p	96	15	,	,	,
cord-012418-6ralcn8p	96	16	41	41	CD
cord-012418-6ralcn8p	96	17	]	]	-RRB-
cord-012418-6ralcn8p	96	18	.	.	.
cord-012418-6ralcn8p	97	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	97	2	is	be	VBZ
cord-012418-6ralcn8p	97	3	then	then	RB
cord-012418-6ralcn8p	97	4	recruited	recruit	VBN
cord-012418-6ralcn8p	97	5	to	to	IN
cord-012418-6ralcn8p	97	6	the	the	DT
cord-012418-6ralcn8p	97	7	platform	platform	NN
cord-012418-6ralcn8p	97	8	via	via	IN
cord-012418-6ralcn8p	97	9	its	-PRON-	PRP$
cord-012418-6ralcn8p	97	10	recognition	recognition	NN
cord-012418-6ralcn8p	97	11	site	site	NN
cord-012418-6ralcn8p	97	12	for	for	IN
cord-012418-6ralcn8p	97	13	the	the	DT
cord-012418-6ralcn8p	97	14	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	97	15	pLxIS	plxis	NN
cord-012418-6ralcn8p	97	16	motif	motif	NN
cord-012418-6ralcn8p	97	17	and	and	CC
cord-012418-6ralcn8p	97	18	gets	get	VBZ
cord-012418-6ralcn8p	97	19	further	further	RB
cord-012418-6ralcn8p	97	20	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	97	21	,	,	,
cord-012418-6ralcn8p	97	22	giving	give	VBG
cord-012418-6ralcn8p	97	23	rise	rise	NN
cord-012418-6ralcn8p	97	24	to	to	IN
cord-012418-6ralcn8p	97	25	two	two	CD
cord-012418-6ralcn8p	97	26	more	more	JJR
cord-012418-6ralcn8p	97	27	protein	protein	NN
cord-012418-6ralcn8p	97	28	forms	form	NNS
cord-012418-6ralcn8p	97	29	(	(	-LRB-
cord-012418-6ralcn8p	97	30	III	III	NNP
cord-012418-6ralcn8p	97	31	and	and	CC
cord-012418-6ralcn8p	97	32	IV	IV	NNP
cord-012418-6ralcn8p	97	33	)	)	-RRB-
cord-012418-6ralcn8p	97	34	whose	whose	WP$
cord-012418-6ralcn8p	97	35	appearance	appearance	NN
cord-012418-6ralcn8p	97	36	correlates	correlate	VBZ
cord-012418-6ralcn8p	97	37	with	with	IN
cord-012418-6ralcn8p	97	38	CBP	CBP	NNP
cord-012418-6ralcn8p	97	39	interaction	interaction	NN
cord-012418-6ralcn8p	97	40	and	and	CC
cord-012418-6ralcn8p	97	41	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	97	42	induction	induction	NN
cord-012418-6ralcn8p	97	43	[	[	-LRB-
cord-012418-6ralcn8p	97	44	39	39	CD
cord-012418-6ralcn8p	97	45	,	,	,
cord-012418-6ralcn8p	97	46	[	[	-LRB-
cord-012418-6ralcn8p	97	47	42	42	CD
cord-012418-6ralcn8p	97	48	]	]	-RRB-
cord-012418-6ralcn8p	98	1	[	[	-LRB-
cord-012418-6ralcn8p	98	2	43	43	CD
cord-012418-6ralcn8p	98	3	]	]	-RRB-
cord-012418-6ralcn8p	98	4	[	[	-LRB-
cord-012418-6ralcn8p	98	5	44	44	CD
cord-012418-6ralcn8p	98	6	]	]	-RRB-
cord-012418-6ralcn8p	98	7	.	.	.
cord-012418-6ralcn8p	99	1	The	the	DT
cord-012418-6ralcn8p	99	2	serine	serine	NN
cord-012418-6ralcn8p	99	3	-	-	HYPH
cord-012418-6ralcn8p	99	4	and	and	CC
cord-012418-6ralcn8p	99	5	threonine	threonine	JJ
cord-012418-6ralcn8p	99	6	-	-	HYPH
cord-012418-6ralcn8p	99	7	rich	rich	JJ
cord-012418-6ralcn8p	99	8	region	region	NN
cord-012418-6ralcn8p	99	9	within	within	IN
cord-012418-6ralcn8p	99	10	the	the	DT
cord-012418-6ralcn8p	99	11	C	c	NN
cord-012418-6ralcn8p	99	12	-	-	HYPH
cord-012418-6ralcn8p	99	13	terminal	terminal	NN
cord-012418-6ralcn8p	99	14	AIE	aie	NN
cord-012418-6ralcn8p	99	15	of	of	IN
cord-012418-6ralcn8p	99	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	99	17	contains	contain	VBZ
cord-012418-6ralcn8p	99	18	two	two	CD
cord-012418-6ralcn8p	99	19	clusters	cluster	NNS
cord-012418-6ralcn8p	99	20	of	of	IN
cord-012418-6ralcn8p	99	21	potential	potential	JJ
cord-012418-6ralcn8p	99	22	phosphoacceptor	phosphoacceptor	NN
cord-012418-6ralcn8p	99	23	residues	residue	NNS
cord-012418-6ralcn8p	99	24	:	:	:
cord-012418-6ralcn8p	99	25	cluster	cluster	NN
cord-012418-6ralcn8p	99	26	1	1	CD
cord-012418-6ralcn8p	99	27	(	(	-LRB-
cord-012418-6ralcn8p	99	28	S385	S385	NNP
cord-012418-6ralcn8p	99	29	/	/	SYM
cord-012418-6ralcn8p	99	30	S386	S386	NNP
cord-012418-6ralcn8p	99	31	)	)	-RRB-
cord-012418-6ralcn8p	99	32	and	and	CC
cord-012418-6ralcn8p	99	33	cluster	cluster	NN
cord-012418-6ralcn8p	99	34	2	2	CD
cord-012418-6ralcn8p	99	35	(	(	-LRB-
cord-012418-6ralcn8p	99	36	S396	S396	NNP
cord-012418-6ralcn8p	99	37	/	/	SYM
cord-012418-6ralcn8p	99	38	S398-S402	S398-S402	NNP
cord-012418-6ralcn8p	99	39	/	/	SYM
cord-012418-6ralcn8p	99	40	T404	t404	NN
cord-012418-6ralcn8p	99	41	/	/	SYM
cord-012418-6ralcn8p	99	42	S405	s405	CD
cord-012418-6ralcn8p	99	43	)	)	-RRB-
cord-012418-6ralcn8p	99	44	[	[	-LRB-
cord-012418-6ralcn8p	99	45	19	19	CD
cord-012418-6ralcn8p	99	46	]	]	-RRB-
cord-012418-6ralcn8p	99	47	.	.	.
cord-012418-6ralcn8p	100	1	First	first	RB
cord-012418-6ralcn8p	100	2	,	,	,
cord-012418-6ralcn8p	100	3	TBK1	TBK1	NNP
cord-012418-6ralcn8p	100	4	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	100	5	cluster	cluster	NN
cord-012418-6ralcn8p	100	6	2	2	CD
cord-012418-6ralcn8p	100	7	residues	residue	NNS
cord-012418-6ralcn8p	100	8	of	of	IN
cord-012418-6ralcn8p	100	9	monomeric	monomeric	JJ
cord-012418-6ralcn8p	100	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	100	11	,	,	,
cord-012418-6ralcn8p	100	12	and	and	CC
cord-012418-6ralcn8p	100	13	the	the	DT
cord-012418-6ralcn8p	100	14	additional	additional	JJ
cord-012418-6ralcn8p	100	15	negative	negative	JJ
cord-012418-6ralcn8p	100	16	charge	charge	NN
cord-012418-6ralcn8p	100	17	induces	induce	VBZ
cord-012418-6ralcn8p	100	18	a	a	DT
cord-012418-6ralcn8p	100	19	reorientation	reorientation	NN
cord-012418-6ralcn8p	100	20	of	of	IN
cord-012418-6ralcn8p	100	21	the	the	DT
cord-012418-6ralcn8p	100	22	AIEs	AIEs	NNP
cord-012418-6ralcn8p	100	23	N	N	NNP
cord-012418-6ralcn8p	100	24	-	-	:
cord-012418-6ralcn8p	100	25	and	and	CC
cord-012418-6ralcn8p	100	26	C	C	NNP
cord-012418-6ralcn8p	100	27	-	-	HYPH
cord-012418-6ralcn8p	100	28	terminal	terminal	NN
cord-012418-6ralcn8p	100	29	of	of	IN
cord-012418-6ralcn8p	100	30	the	the	DT
cord-012418-6ralcn8p	100	31	IAD	IAD	NNP
cord-012418-6ralcn8p	100	32	[	[	-LRB-
cord-012418-6ralcn8p	100	33	20	20	CD
cord-012418-6ralcn8p	100	34	,	,	,
cord-012418-6ralcn8p	100	35	45	45	CD
cord-012418-6ralcn8p	100	36	]	]	-RRB-
cord-012418-6ralcn8p	100	37	.	.	.
cord-012418-6ralcn8p	101	1	This	this	DT
cord-012418-6ralcn8p	101	2	unmasks	unmask	VBZ
cord-012418-6ralcn8p	101	3	a	a	DT
cord-012418-6ralcn8p	101	4	hydrophobic	hydrophobic	JJ
cord-012418-6ralcn8p	101	5	binding	bind	VBG
cord-012418-6ralcn8p	101	6	pocket	pocket	NN
cord-012418-6ralcn8p	101	7	required	require	VBN
cord-012418-6ralcn8p	101	8	for	for	IN
cord-012418-6ralcn8p	101	9	further	further	JJ
cord-012418-6ralcn8p	101	10	protein	protein	NN
cord-012418-6ralcn8p	101	11	interactions	interaction	NNS
cord-012418-6ralcn8p	101	12	and	and	CC
cord-012418-6ralcn8p	101	13	renders	render	VBZ
cord-012418-6ralcn8p	101	14	the	the	DT
cord-012418-6ralcn8p	101	15	C	c	NN
cord-012418-6ralcn8p	101	16	-	-	HYPH
cord-012418-6ralcn8p	101	17	terminal	terminal	NN
cord-012418-6ralcn8p	101	18	tail	tail	NN
cord-012418-6ralcn8p	101	19	(	(	-LRB-
cord-012418-6ralcn8p	101	20	CTT	CTT	NNP
cord-012418-6ralcn8p	101	21	)	)	-RRB-
cord-012418-6ralcn8p	101	22	accessible	accessible	JJ
cord-012418-6ralcn8p	101	23	for	for	IN
cord-012418-6ralcn8p	101	24	interactions	interaction	NNS
cord-012418-6ralcn8p	101	25	[	[	-LRB-
cord-012418-6ralcn8p	101	26	45	45	CD
cord-012418-6ralcn8p	101	27	,	,	,
cord-012418-6ralcn8p	101	28	46	46	CD
cord-012418-6ralcn8p	101	29	]	]	-RRB-
cord-012418-6ralcn8p	101	30	.	.	.
cord-012418-6ralcn8p	102	1	Additionally	additionally	RB
cord-012418-6ralcn8p	102	2	,	,	,
cord-012418-6ralcn8p	102	3	the	the	DT
cord-012418-6ralcn8p	102	4	conformational	conformational	JJ
cord-012418-6ralcn8p	102	5	change	change	NN
cord-012418-6ralcn8p	102	6	is	be	VBZ
cord-012418-6ralcn8p	102	7	relayed	relay	VBN
cord-012418-6ralcn8p	102	8	to	to	IN
cord-012418-6ralcn8p	102	9	the	the	DT
cord-012418-6ralcn8p	102	10	DBD	DBD	NNP
cord-012418-6ralcn8p	102	11	to	to	TO
cord-012418-6ralcn8p	102	12	enhance	enhance	VB
cord-012418-6ralcn8p	102	13	the	the	DT
cord-012418-6ralcn8p	102	14	DNA	dna	NN
cord-012418-6ralcn8p	102	15	-	-	HYPH
cord-012418-6ralcn8p	102	16	binding	bind	VBG
cord-012418-6ralcn8p	102	17	affinity	affinity	NN
cord-012418-6ralcn8p	102	18	.	.	.
cord-012418-6ralcn8p	103	1	The	the	DT
cord-012418-6ralcn8p	103	2	residues	residue	NNS
cord-012418-6ralcn8p	103	3	of	of	IN
cord-012418-6ralcn8p	103	4	cluster	cluster	NN
cord-012418-6ralcn8p	103	5	2	2	CD
cord-012418-6ralcn8p	103	6	are	be	VBP
cord-012418-6ralcn8p	103	7	functionally	functionally	RB
cord-012418-6ralcn8p	103	8	largely	largely	RB
cord-012418-6ralcn8p	103	9	redundant	redundant	JJ
cord-012418-6ralcn8p	103	10	in	in	IN
cord-012418-6ralcn8p	103	11	terms	term	NNS
cord-012418-6ralcn8p	103	12	of	of	IN
cord-012418-6ralcn8p	103	13	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	103	14	-	-	HYPH
cord-012418-6ralcn8p	103	15	mediated	mediate	VBN
cord-012418-6ralcn8p	103	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	103	17	activation	activation	NN
cord-012418-6ralcn8p	103	18	,	,	,
cord-012418-6ralcn8p	103	19	though	though	IN
cord-012418-6ralcn8p	103	20	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	103	21	of	of	IN
cord-012418-6ralcn8p	103	22	S396	S396	NNP
cord-012418-6ralcn8p	103	23	seems	seem	VBZ
cord-012418-6ralcn8p	103	24	to	to	TO
cord-012418-6ralcn8p	103	25	predominate	predominate	VB
cord-012418-6ralcn8p	103	26	in	in	IN
cord-012418-6ralcn8p	103	27	vivo	vivo	NNP
cord-012418-6ralcn8p	103	28	[	[	-LRB-
cord-012418-6ralcn8p	103	29	37	37	CD
cord-012418-6ralcn8p	103	30	,	,	,
cord-012418-6ralcn8p	103	31	47	47	CD
cord-012418-6ralcn8p	103	32	]	]	-RRB-
cord-012418-6ralcn8p	103	33	.	.	.
cord-012418-6ralcn8p	104	1	The	the	DT
cord-012418-6ralcn8p	104	2	alternative	alternative	JJ
cord-012418-6ralcn8p	104	3	use	use	NN
cord-012418-6ralcn8p	104	4	of	of	IN
cord-012418-6ralcn8p	104	5	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	104	6	sites	site	NNS
cord-012418-6ralcn8p	104	7	could	could	MD
cord-012418-6ralcn8p	104	8	be	be	VB
cord-012418-6ralcn8p	104	9	the	the	DT
cord-012418-6ralcn8p	104	10	reason	reason	NN
cord-012418-6ralcn8p	104	11	why	why	WRB
cord-012418-6ralcn8p	104	12	some	some	DT
cord-012418-6ralcn8p	104	13	studies	study	NNS
cord-012418-6ralcn8p	104	14	found	find	VBD
cord-012418-6ralcn8p	104	15	that	that	IN
cord-012418-6ralcn8p	104	16	mutation	mutation	NN
cord-012418-6ralcn8p	104	17	of	of	IN
cord-012418-6ralcn8p	104	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	104	19	S396	S396	NNP
cord-012418-6ralcn8p	104	20	to	to	IN
cord-012418-6ralcn8p	104	21	alanine	alanine	NN
cord-012418-6ralcn8p	104	22	sometimes	sometimes	RB
cord-012418-6ralcn8p	104	23	retained	retain	VBD
cord-012418-6ralcn8p	104	24	biological	biological	JJ
cord-012418-6ralcn8p	104	25	function	function	NN
cord-012418-6ralcn8p	104	26	(	(	-LRB-
cord-012418-6ralcn8p	104	27	for	for	IN
cord-012418-6ralcn8p	104	28	example	example	NN
cord-012418-6ralcn8p	104	29	in	in	IN
cord-012418-6ralcn8p	104	30	[	[	-LRB-
cord-012418-6ralcn8p	104	31	48	48	CD
cord-012418-6ralcn8p	104	32	,	,	,
cord-012418-6ralcn8p	104	33	49	49	CD
cord-012418-6ralcn8p	104	34	]	]	-RRB-
cord-012418-6ralcn8p	104	35	)	)	-RRB-
cord-012418-6ralcn8p	104	36	.	.	.
cord-012418-6ralcn8p	105	1	Second	second	JJ
cord-012418-6ralcn8p	105	2	,	,	,
cord-012418-6ralcn8p	105	3	and	and	CC
cord-012418-6ralcn8p	105	4	induced	induce	VBN
cord-012418-6ralcn8p	105	5	by	by	IN
cord-012418-6ralcn8p	105	6	the	the	DT
cord-012418-6ralcn8p	105	7	first	first	JJ
cord-012418-6ralcn8p	105	8	modification	modification	NN
cord-012418-6ralcn8p	105	9	,	,	,
cord-012418-6ralcn8p	105	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	105	11	gets	get	VBZ
cord-012418-6ralcn8p	105	12	further	further	RB
cord-012418-6ralcn8p	105	13	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	105	14	at	at	IN
cord-012418-6ralcn8p	105	15	S386	s386	PRP
cord-012418-6ralcn8p	105	16	which	which	WDT
cord-012418-6ralcn8p	105	17	is	be	VBZ
cord-012418-6ralcn8p	105	18	pivotal	pivotal	JJ
cord-012418-6ralcn8p	105	19	for	for	IN
cord-012418-6ralcn8p	105	20	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	105	21	[	[	-LRB-
cord-012418-6ralcn8p	105	22	45	45	CD
cord-012418-6ralcn8p	105	23	,	,	,
cord-012418-6ralcn8p	105	24	50	50	CD
cord-012418-6ralcn8p	105	25	]	]	-RRB-
cord-012418-6ralcn8p	105	26	.	.	.
cord-012418-6ralcn8p	106	1	Consistently	consistently	RB
cord-012418-6ralcn8p	106	2	,	,	,
cord-012418-6ralcn8p	106	3	100	100	CD
cord-012418-6ralcn8p	106	4	%	%	NN
cord-012418-6ralcn8p	106	5	of	of	IN
cord-012418-6ralcn8p	106	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	106	7	dimers	dimer	NNS
cord-012418-6ralcn8p	106	8	generated	generate	VBN
cord-012418-6ralcn8p	106	9	in	in	IN
cord-012418-6ralcn8p	106	10	vitro	vitro	FW
cord-012418-6ralcn8p	106	11	by	by	IN
cord-012418-6ralcn8p	106	12	incubation	incubation	NN
cord-012418-6ralcn8p	106	13	with	with	IN
cord-012418-6ralcn8p	106	14	TBK1	TBK1	NNP
cord-012418-6ralcn8p	106	15	are	be	VBP
cord-012418-6ralcn8p	106	16	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	106	17	at	at	IN
cord-012418-6ralcn8p	106	18	both	both	DT
cord-012418-6ralcn8p	106	19	clusters	cluster	NNS
cord-012418-6ralcn8p	106	20	[	[	-LRB-
cord-012418-6ralcn8p	106	21	45	45	CD
cord-012418-6ralcn8p	106	22	]	]	-RRB-
cord-012418-6ralcn8p	106	23	.	.	.
cord-012418-6ralcn8p	107	1	In	in	IN
cord-012418-6ralcn8p	107	2	contrast	contrast	NN
cord-012418-6ralcn8p	107	3	to	to	IN
cord-012418-6ralcn8p	107	4	cluster	cluster	NN
cord-012418-6ralcn8p	107	5	2	2	CD
cord-012418-6ralcn8p	107	6	,	,	,
cord-012418-6ralcn8p	107	7	added	add	VBN
cord-012418-6ralcn8p	107	8	phosphate	phosphate	NN
cord-012418-6ralcn8p	107	9	groups	group	NNS
cord-012418-6ralcn8p	107	10	at	at	IN
cord-012418-6ralcn8p	107	11	cluster	cluster	NN
cord-012418-6ralcn8p	107	12	1	1	CD
cord-012418-6ralcn8p	107	13	residues	residue	NNS
cord-012418-6ralcn8p	107	14	have	have	VBP
cord-012418-6ralcn8p	107	15	distinct	distinct	JJ
cord-012418-6ralcn8p	107	16	effects	effect	NNS
cord-012418-6ralcn8p	107	17	:	:	:
cord-012418-6ralcn8p	107	18	Addition	addition	NN
cord-012418-6ralcn8p	107	19	of	of	IN
cord-012418-6ralcn8p	107	20	a	a	DT
cord-012418-6ralcn8p	107	21	phosphate	phosphate	NN
cord-012418-6ralcn8p	107	22	group	group	NN
cord-012418-6ralcn8p	107	23	at	at	IN
cord-012418-6ralcn8p	107	24	S386	s386	PRP
cord-012418-6ralcn8p	107	25	promotes	promote	VBZ
cord-012418-6ralcn8p	107	26	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	107	27	of	of	IN
cord-012418-6ralcn8p	107	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	107	29	and	and	CC
cord-012418-6ralcn8p	107	30	strengthens	strengthen	VBZ
cord-012418-6ralcn8p	107	31	interaction	interaction	NN
cord-012418-6ralcn8p	107	32	with	with	IN
cord-012418-6ralcn8p	107	33	the	the	DT
cord-012418-6ralcn8p	107	34	coactivator	coactivator	NN
cord-012418-6ralcn8p	107	35	CBP	CBP	NNP
cord-012418-6ralcn8p	107	36	,	,	,
cord-012418-6ralcn8p	107	37	while	while	IN
cord-012418-6ralcn8p	107	38	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	107	39	of	of	IN
cord-012418-6ralcn8p	107	40	S385	S385	NNP
cord-012418-6ralcn8p	107	41	negatively	negatively	RB
cord-012418-6ralcn8p	107	42	affects	affect	VBZ
cord-012418-6ralcn8p	107	43	both	both	DT
cord-012418-6ralcn8p	107	44	interactions	interaction	NNS
cord-012418-6ralcn8p	107	45	[	[	-LRB-
cord-012418-6ralcn8p	107	46	19	19	CD
cord-012418-6ralcn8p	107	47	,	,	,
cord-012418-6ralcn8p	107	48	50	50	CD
cord-012418-6ralcn8p	107	49	,	,	,
cord-012418-6ralcn8p	107	50	51	51	CD
cord-012418-6ralcn8p	107	51	]	]	-RRB-
cord-012418-6ralcn8p	107	52	.	.	.
cord-012418-6ralcn8p	108	1	By	by	IN
cord-012418-6ralcn8p	108	2	relief	relief	NN
cord-012418-6ralcn8p	108	3	of	of	IN
cord-012418-6ralcn8p	108	4	the	the	DT
cord-012418-6ralcn8p	108	5	auto	auto	NN
cord-012418-6ralcn8p	108	6	-	-	HYPH
cord-012418-6ralcn8p	108	7	inhibition	inhibition	NN
cord-012418-6ralcn8p	108	8	,	,	,
cord-012418-6ralcn8p	108	9	phosphorylated	phosphorylate	VBD
cord-012418-6ralcn8p	108	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	108	11	can	can	MD
cord-012418-6ralcn8p	108	12	dimerise	dimerise	VB
cord-012418-6ralcn8p	108	13	and	and	CC
cord-012418-6ralcn8p	108	14	associate	associate	VB
cord-012418-6ralcn8p	108	15	with	with	IN
cord-012418-6ralcn8p	108	16	the	the	DT
cord-012418-6ralcn8p	108	17	coactivators	coactivators	NNP
cord-012418-6ralcn8p	108	18	CBP	CBP	NNP
cord-012418-6ralcn8p	108	19	/	/	SYM
cord-012418-6ralcn8p	108	20	p300	p300	NNP
cord-012418-6ralcn8p	108	21	to	to	TO
cord-012418-6ralcn8p	108	22	form	form	VB
cord-012418-6ralcn8p	108	23	an	an	DT
cord-012418-6ralcn8p	108	24	active	active	JJ
cord-012418-6ralcn8p	108	25	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	108	26	.	.	.
cord-012418-6ralcn8p	109	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	109	2	can	can	MD
cord-012418-6ralcn8p	109	3	also	also	RB
cord-012418-6ralcn8p	109	4	be	be	VB
cord-012418-6ralcn8p	109	5	rendered	render	VBN
cord-012418-6ralcn8p	109	6	constitutively	constitutively	RB
cord-012418-6ralcn8p	109	7	active	active	JJ
cord-012418-6ralcn8p	109	8	by	by	IN
cord-012418-6ralcn8p	109	9	exchange	exchange	NN
cord-012418-6ralcn8p	109	10	of	of	IN
cord-012418-6ralcn8p	109	11	the	the	DT
cord-012418-6ralcn8p	109	12	five	five	CD
cord-012418-6ralcn8p	109	13	phosphoacceptor	phosphoacceptor	NN
cord-012418-6ralcn8p	109	14	sites	site	NNS
cord-012418-6ralcn8p	109	15	in	in	IN
cord-012418-6ralcn8p	109	16	cluster	cluster	NN
cord-012418-6ralcn8p	109	17	2	2	CD
cord-012418-6ralcn8p	109	18	to	to	IN
cord-012418-6ralcn8p	109	19	aspartic	aspartic	JJ
cord-012418-6ralcn8p	109	20	or	or	CC
cord-012418-6ralcn8p	109	21	glutamic	glutamic	NN
cord-012418-6ralcn8p	109	22	acid	acid	NN
cord-012418-6ralcn8p	109	23	residues	residue	NNS
cord-012418-6ralcn8p	109	24	(	(	-LRB-
cord-012418-6ralcn8p	109	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	109	26	-	-	HYPH
cord-012418-6ralcn8p	109	27	5D	5D	NNP
cord-012418-6ralcn8p	109	28	or	or	CC
cord-012418-6ralcn8p	109	29	-5E	-5E	NNP
cord-012418-6ralcn8p	109	30	,	,	,
cord-012418-6ralcn8p	109	31	respectively	respectively	RB
cord-012418-6ralcn8p	109	32	)	)	-RRB-
cord-012418-6ralcn8p	109	33	,	,	,
cord-012418-6ralcn8p	109	34	and	and	CC
cord-012418-6ralcn8p	109	35	these	these	DT
cord-012418-6ralcn8p	109	36	mutants	mutant	NNS
cord-012418-6ralcn8p	109	37	display	display	VBP
cord-012418-6ralcn8p	109	38	a	a	DT
cord-012418-6ralcn8p	109	39	strong	strong	JJ
cord-012418-6ralcn8p	109	40	tendency	tendency	NN
cord-012418-6ralcn8p	109	41	to	to	TO
cord-012418-6ralcn8p	109	42	acquire	acquire	VB
cord-012418-6ralcn8p	109	43	the	the	DT
cord-012418-6ralcn8p	109	44	cluster	cluster	NN
cord-012418-6ralcn8p	109	45	1	1	CD
cord-012418-6ralcn8p	109	46	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	109	47	and	and	CC
cord-012418-6ralcn8p	109	48	dimerise	dimerise	NN
cord-012418-6ralcn8p	109	49	[	[	-LRB-
cord-012418-6ralcn8p	109	50	19	19	CD
cord-012418-6ralcn8p	109	51	,	,	,
cord-012418-6ralcn8p	109	52	45	45	CD
cord-012418-6ralcn8p	109	53	]	]	-RRB-
cord-012418-6ralcn8p	109	54	.	.	.
cord-012418-6ralcn8p	110	1	Since	since	IN
cord-012418-6ralcn8p	110	2	the	the	DT
cord-012418-6ralcn8p	110	3	first	first	JJ
cord-012418-6ralcn8p	110	4	description	description	NN
cord-012418-6ralcn8p	110	5	of	of	IN
cord-012418-6ralcn8p	110	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	110	7	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	110	8	,	,	,
cord-012418-6ralcn8p	110	9	it	-PRON-	PRP
cord-012418-6ralcn8p	110	10	is	be	VBZ
cord-012418-6ralcn8p	110	11	generally	generally	RB
cord-012418-6ralcn8p	110	12	noted	note	VBN
cord-012418-6ralcn8p	110	13	as	as	IN
cord-012418-6ralcn8p	110	14	the	the	DT
cord-012418-6ralcn8p	110	15	second	second	JJ
cord-012418-6ralcn8p	110	16	step	step	NN
cord-012418-6ralcn8p	110	17	of	of	IN
cord-012418-6ralcn8p	110	18	activation	activation	NN
cord-012418-6ralcn8p	110	19	after	after	IN
cord-012418-6ralcn8p	110	20	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	110	21	[	[	-LRB-
cord-012418-6ralcn8p	110	22	19	19	CD
cord-012418-6ralcn8p	110	23	]	]	-RRB-
cord-012418-6ralcn8p	110	24	.	.	.
cord-012418-6ralcn8p	111	1	Formation	formation	NN
cord-012418-6ralcn8p	111	2	of	of	IN
cord-012418-6ralcn8p	111	3	dimers	dimer	NNS
cord-012418-6ralcn8p	111	4	requires	require	VBZ
cord-012418-6ralcn8p	111	5	homotypic	homotypic	JJ
cord-012418-6ralcn8p	111	6	interactions	interaction	NNS
cord-012418-6ralcn8p	111	7	of	of	IN
cord-012418-6ralcn8p	111	8	the	the	DT
cord-012418-6ralcn8p	111	9	IAD	IAD	NNP
cord-012418-6ralcn8p	111	10	with	with	IN
cord-012418-6ralcn8p	111	11	a	a	DT
cord-012418-6ralcn8p	111	12	second	second	JJ
cord-012418-6ralcn8p	111	13	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	111	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	111	15	molecule	molecule	NN
cord-012418-6ralcn8p	111	16	.	.	.
cord-012418-6ralcn8p	112	1	Structural	structural	JJ
cord-012418-6ralcn8p	112	2	studies	study	NNS
cord-012418-6ralcn8p	112	3	revealed	reveal	VBD
cord-012418-6ralcn8p	112	4	that	that	IN
cord-012418-6ralcn8p	112	5	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	112	6	of	of	IN
cord-012418-6ralcn8p	112	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	112	8	in	in	IN
cord-012418-6ralcn8p	112	9	fact	fact	NN
cord-012418-6ralcn8p	112	10	modifies	modify	VBZ
cord-012418-6ralcn8p	112	11	a	a	DT
cord-012418-6ralcn8p	112	12	pLxIS	plxis	JJ
cord-012418-6ralcn8p	112	13	motif	motif	NN
cord-012418-6ralcn8p	112	14	in	in	IN
cord-012418-6ralcn8p	112	15	the	the	DT
cord-012418-6ralcn8p	112	16	CTT	CTT	NNP
cord-012418-6ralcn8p	112	17	,	,	,
cord-012418-6ralcn8p	112	18	similar	similar	JJ
cord-012418-6ralcn8p	112	19	to	to	IN
cord-012418-6ralcn8p	112	20	the	the	DT
cord-012418-6ralcn8p	112	21	motif	motif	NN
cord-012418-6ralcn8p	112	22	initiating	initiate	VBG
cord-012418-6ralcn8p	112	23	recruitment	recruitment	NN
cord-012418-6ralcn8p	112	24	of	of	IN
cord-012418-6ralcn8p	112	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	112	26	to	to	IN
cord-012418-6ralcn8p	112	27	the	the	DT
cord-012418-6ralcn8p	112	28	adaptor	adaptor	NN
cord-012418-6ralcn8p	112	29	platform	platform	NN
cord-012418-6ralcn8p	112	30	[	[	-LRB-
cord-012418-6ralcn8p	112	31	42	42	CD
cord-012418-6ralcn8p	112	32	]	]	-RRB-
cord-012418-6ralcn8p	112	33	.	.	.
cord-012418-6ralcn8p	113	1	Enabled	enable	VBN
cord-012418-6ralcn8p	113	2	by	by	IN
cord-012418-6ralcn8p	113	3	the	the	DT
cord-012418-6ralcn8p	113	4	negative	negative	JJ
cord-012418-6ralcn8p	113	5	charge	charge	NN
cord-012418-6ralcn8p	113	6	at	at	IN
cord-012418-6ralcn8p	113	7	S386	S386	NNP
cord-012418-6ralcn8p	113	8	after	after	IN
cord-012418-6ralcn8p	113	9	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	113	10	,	,	,
cord-012418-6ralcn8p	113	11	the	the	DT
cord-012418-6ralcn8p	113	12	extended	extended	JJ
cord-012418-6ralcn8p	113	13	CTT	CTT	NNP
cord-012418-6ralcn8p	113	14	can	can	MD
cord-012418-6ralcn8p	113	15	interact	interact	VB
cord-012418-6ralcn8p	113	16	with	with	IN
cord-012418-6ralcn8p	113	17	the	the	DT
cord-012418-6ralcn8p	113	18	pLxIS	plxis	NN
cord-012418-6ralcn8p	113	19	-	-	HYPH
cord-012418-6ralcn8p	113	20	binding	bind	VBG
cord-012418-6ralcn8p	113	21	surface	surface	NN
cord-012418-6ralcn8p	113	22	of	of	IN
cord-012418-6ralcn8p	113	23	a	a	DT
cord-012418-6ralcn8p	113	24	second	second	JJ
cord-012418-6ralcn8p	113	25	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	113	26	IRF3	IRF3	NNP
cord-012418-6ralcn8p	113	27	monomer	monomer	NN
cord-012418-6ralcn8p	113	28	to	to	TO
cord-012418-6ralcn8p	113	29	form	form	VB
cord-012418-6ralcn8p	113	30	a	a	DT
cord-012418-6ralcn8p	113	31	domain	domain	NN
cord-012418-6ralcn8p	113	32	-	-	HYPH
cord-012418-6ralcn8p	113	33	swapped	swap	VBN
cord-012418-6ralcn8p	113	34	dimer	dimer	NN
cord-012418-6ralcn8p	113	35	(	(	-LRB-
cord-012418-6ralcn8p	113	36	indicated	indicate	VBN
cord-012418-6ralcn8p	113	37	in	in	IN
cord-012418-6ralcn8p	113	38	Figure	figure	NN
cord-012418-6ralcn8p	113	39	2	2	CD
cord-012418-6ralcn8p	113	40	)	)	-RRB-
cord-012418-6ralcn8p	113	41	.	.	.
cord-012418-6ralcn8p	114	1	Zhao	Zhao	NNP
cord-012418-6ralcn8p	114	2	and	and	CC
cord-012418-6ralcn8p	114	3	colleagues	colleague	NNS
cord-012418-6ralcn8p	114	4	further	further	RB
cord-012418-6ralcn8p	114	5	proposed	propose	VBD
cord-012418-6ralcn8p	114	6	that	that	IN
cord-012418-6ralcn8p	114	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	114	8	dimerises	dimerise	NNS
cord-012418-6ralcn8p	114	9	at	at	IN
cord-012418-6ralcn8p	114	10	the	the	DT
cord-012418-6ralcn8p	114	11	adaptor	adaptor	NN
cord-012418-6ralcn8p	114	12	platform	platform	NN
cord-012418-6ralcn8p	114	13	to	to	TO
cord-012418-6ralcn8p	114	14	regain	regain	VB
cord-012418-6ralcn8p	114	15	stability	stability	NN
cord-012418-6ralcn8p	114	16	,	,	,
cord-012418-6ralcn8p	114	17	but	but	CC
cord-012418-6ralcn8p	114	18	this	this	DT
cord-012418-6ralcn8p	114	19	was	be	VBD
cord-012418-6ralcn8p	114	20	not	not	RB
cord-012418-6ralcn8p	114	21	yet	yet	RB
cord-012418-6ralcn8p	114	22	confirmed	confirm	VBN
cord-012418-6ralcn8p	114	23	.	.	.
cord-012418-6ralcn8p	115	1	Due	due	IN
cord-012418-6ralcn8p	115	2	to	to	IN
cord-012418-6ralcn8p	115	3	repulsion	repulsion	NN
cord-012418-6ralcn8p	115	4	caused	cause	VBN
cord-012418-6ralcn8p	115	5	by	by	IN
cord-012418-6ralcn8p	115	6	the	the	DT
cord-012418-6ralcn8p	115	7	newly	newly	RB
cord-012418-6ralcn8p	115	8	acquired	acquire	VBN
cord-012418-6ralcn8p	115	9	negative	negative	JJ
cord-012418-6ralcn8p	115	10	charges	charge	NNS
cord-012418-6ralcn8p	115	11	,	,	,
cord-012418-6ralcn8p	115	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	115	13	proteins	protein	NNS
cord-012418-6ralcn8p	115	14	could	could	MD
cord-012418-6ralcn8p	115	15	also	also	RB
cord-012418-6ralcn8p	115	16	dissociate	dissociate	VB
cord-012418-6ralcn8p	115	17	from	from	IN
cord-012418-6ralcn8p	115	18	the	the	DT
cord-012418-6ralcn8p	115	19	adaptor	adaptor	NN
cord-012418-6ralcn8p	115	20	complex	complex	NN
cord-012418-6ralcn8p	115	21	before	before	IN
cord-012418-6ralcn8p	115	22	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	115	23	and	and	CC
cord-012418-6ralcn8p	115	24	converge	converge	VBP
cord-012418-6ralcn8p	115	25	subsequently	subsequently	RB
cord-012418-6ralcn8p	115	26	either	either	RB
cord-012418-6ralcn8p	115	27	(	(	-LRB-
cord-012418-6ralcn8p	115	28	i	i	NN
cord-012418-6ralcn8p	115	29	)	)	-RRB-
cord-012418-6ralcn8p	115	30	in	in	IN
cord-012418-6ralcn8p	115	31	the	the	DT
cord-012418-6ralcn8p	115	32	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	115	33	,	,	,
cord-012418-6ralcn8p	115	34	(	(	-LRB-
cord-012418-6ralcn8p	115	35	ii	ii	NN
cord-012418-6ralcn8p	115	36	)	)	-RRB-
cord-012418-6ralcn8p	116	1	after	after	IN
cord-012418-6ralcn8p	116	2	translocation	translocation	NN
cord-012418-6ralcn8p	116	3	into	into	IN
cord-012418-6ralcn8p	116	4	the	the	DT
cord-012418-6ralcn8p	116	5	nucleus	nucleus	NN
cord-012418-6ralcn8p	116	6	or	or	CC
cord-012418-6ralcn8p	116	7	(	(	-LRB-
cord-012418-6ralcn8p	116	8	iii	iii	NN
cord-012418-6ralcn8p	116	9	)	)	-RRB-
cord-012418-6ralcn8p	116	10	after	after	IN
cord-012418-6ralcn8p	116	11	engagement	engagement	NN
cord-012418-6ralcn8p	116	12	of	of	IN
cord-012418-6ralcn8p	116	13	coactivators	coactivator	NNS
cord-012418-6ralcn8p	116	14	during	during	IN
cord-012418-6ralcn8p	116	15	recruitment	recruitment	NN
cord-012418-6ralcn8p	116	16	to	to	IN
cord-012418-6ralcn8p	116	17	the	the	DT
cord-012418-6ralcn8p	116	18	enhancer	enhancer	NN
cord-012418-6ralcn8p	116	19	.	.	.
cord-012418-6ralcn8p	117	1	Further	further	RB
cord-012418-6ralcn8p	117	2	,	,	,
cord-012418-6ralcn8p	117	3	the	the	DT
cord-012418-6ralcn8p	117	4	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	117	5	-	-	HYPH
cord-012418-6ralcn8p	117	6	induced	induce	VBN
cord-012418-6ralcn8p	117	7	rearrangement	rearrangement	NN
cord-012418-6ralcn8p	117	8	of	of	IN
cord-012418-6ralcn8p	117	9	the	the	DT
cord-012418-6ralcn8p	117	10	AIE	AIE	NNP
cord-012418-6ralcn8p	117	11	unmasks	unmask	VBZ
cord-012418-6ralcn8p	117	12	a	a	DT
cord-012418-6ralcn8p	117	13	hydrophobic	hydrophobic	JJ
cord-012418-6ralcn8p	117	14	binding	binding	NN
cord-012418-6ralcn8p	117	15	site	site	NN
cord-012418-6ralcn8p	117	16	of	of	IN
cord-012418-6ralcn8p	117	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	117	18	and	and	CC
cord-012418-6ralcn8p	117	19	enables	enable	VBZ
cord-012418-6ralcn8p	117	20	the	the	DT
cord-012418-6ralcn8p	117	21	interaction	interaction	NN
cord-012418-6ralcn8p	117	22	with	with	IN
cord-012418-6ralcn8p	117	23	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	117	24	coactivators	coactivator	NNS
cord-012418-6ralcn8p	117	25	[	[	-LRB-
cord-012418-6ralcn8p	117	26	21	21	CD
cord-012418-6ralcn8p	117	27	,	,	,
cord-012418-6ralcn8p	117	28	37	37	CD
cord-012418-6ralcn8p	117	29	,	,	,
cord-012418-6ralcn8p	117	30	52	52	CD
cord-012418-6ralcn8p	117	31	,	,	,
cord-012418-6ralcn8p	117	32	53	53	CD
cord-012418-6ralcn8p	117	33	]	]	-RRB-
cord-012418-6ralcn8p	117	34	.	.	.
cord-012418-6ralcn8p	118	1	Association	Association	NNP
cord-012418-6ralcn8p	118	2	of	of	IN
cord-012418-6ralcn8p	118	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	118	4	with	with	IN
cord-012418-6ralcn8p	118	5	the	the	DT
cord-012418-6ralcn8p	118	6	histone	histone	NN
cord-012418-6ralcn8p	118	7	-	-	HYPH
cord-012418-6ralcn8p	118	8	modifying	modify	VBG
cord-012418-6ralcn8p	118	9	lysine	lysine	NN
cord-012418-6ralcn8p	118	10	acetyltransferases	acetyltransferase	NNS
cord-012418-6ralcn8p	118	11	(	(	-LRB-
cord-012418-6ralcn8p	118	12	KATs	KATs	NNP
cord-012418-6ralcn8p	118	13	)	)	-RRB-
cord-012418-6ralcn8p	118	14	CREB	CREB	NNP
cord-012418-6ralcn8p	118	15	-	-	HYPH
cord-012418-6ralcn8p	118	16	binding	bind	VBG
cord-012418-6ralcn8p	118	17	protein	protein	NN
cord-012418-6ralcn8p	118	18	(	(	-LRB-
cord-012418-6ralcn8p	118	19	CBP	CBP	NNP
cord-012418-6ralcn8p	118	20	,	,	,
cord-012418-6ralcn8p	118	21	or	or	CC
cord-012418-6ralcn8p	118	22	KAT3A	KAT3A	NNP
cord-012418-6ralcn8p	118	23	)	)	-RRB-
cord-012418-6ralcn8p	119	1	and/or	and/or	CC
cord-012418-6ralcn8p	120	1	p300	p300	NNP
cord-012418-6ralcn8p	120	2	(	(	-LRB-
cord-012418-6ralcn8p	120	3	KAT3B	KAT3B	NNP
cord-012418-6ralcn8p	120	4	)	)	-RRB-
cord-012418-6ralcn8p	121	1	in	in	IN
cord-012418-6ralcn8p	121	2	form	form	NN
cord-012418-6ralcn8p	121	3	of	of	IN
cord-012418-6ralcn8p	121	4	a	a	DT
cord-012418-6ralcn8p	121	5	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	121	6	is	be	VBZ
cord-012418-6ralcn8p	121	7	pivotal	pivotal	JJ
cord-012418-6ralcn8p	121	8	for	for	IN
cord-012418-6ralcn8p	121	9	the	the	DT
cord-012418-6ralcn8p	121	10	ability	ability	NN
cord-012418-6ralcn8p	121	11	of	of	IN
cord-012418-6ralcn8p	121	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	121	13	to	to	TO
cord-012418-6ralcn8p	121	14	trans	trans	VB
cord-012418-6ralcn8p	121	15	-	-	JJ
cord-012418-6ralcn8p	121	16	activate	activate	VB
cord-012418-6ralcn8p	121	17	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	121	18	expression	expression	NN
cord-012418-6ralcn8p	121	19	[	[	-LRB-
cord-012418-6ralcn8p	121	20	22	22	CD
cord-012418-6ralcn8p	121	21	,	,	,
cord-012418-6ralcn8p	121	22	54	54	CD
cord-012418-6ralcn8p	121	23	,	,	,
cord-012418-6ralcn8p	121	24	55	55	CD
cord-012418-6ralcn8p	121	25	]	]	-RRB-
cord-012418-6ralcn8p	121	26	.	.	.
cord-012418-6ralcn8p	122	1	These	these	DT
cord-012418-6ralcn8p	122	2	coactivators	coactivator	NNS
cord-012418-6ralcn8p	122	3	are	be	VBP
cord-012418-6ralcn8p	122	4	large	large	JJ
cord-012418-6ralcn8p	122	5	proteins	protein	NNS
cord-012418-6ralcn8p	122	6	that	that	WDT
cord-012418-6ralcn8p	122	7	contain	contain	VBP
cord-012418-6ralcn8p	122	8	several	several	JJ
cord-012418-6ralcn8p	122	9	folded	fold	VBN
cord-012418-6ralcn8p	122	10	domains	domain	NNS
cord-012418-6ralcn8p	122	11	and	and	CC
cord-012418-6ralcn8p	122	12	additionally	additionally	RB
cord-012418-6ralcn8p	122	13	a	a	DT
cord-012418-6ralcn8p	122	14	big	big	JJ
cord-012418-6ralcn8p	122	15	share	share	NN
cord-012418-6ralcn8p	122	16	of	of	IN
cord-012418-6ralcn8p	122	17	intrinsically	intrinsically	RB
cord-012418-6ralcn8p	122	18	disordered	disordered	JJ
cord-012418-6ralcn8p	122	19	regions	region	NNS
cord-012418-6ralcn8p	122	20	that	that	WDT
cord-012418-6ralcn8p	122	21	allow	allow	VBP
cord-012418-6ralcn8p	122	22	for	for	IN
cord-012418-6ralcn8p	122	23	specific	specific	JJ
cord-012418-6ralcn8p	122	24	binding	binding	NN
cord-012418-6ralcn8p	122	25	to	to	IN
cord-012418-6ralcn8p	122	26	numerous	numerous	JJ
cord-012418-6ralcn8p	122	27	factors	factor	NNS
cord-012418-6ralcn8p	122	28	upon	upon	IN
cord-012418-6ralcn8p	122	29	interaction	interaction	NN
cord-012418-6ralcn8p	122	30	[	[	-LRB-
cord-012418-6ralcn8p	122	31	56	56	CD
cord-012418-6ralcn8p	122	32	]	]	-RRB-
cord-012418-6ralcn8p	122	33	.	.	.
cord-012418-6ralcn8p	123	1	Their	-PRON-	PRP$
cord-012418-6ralcn8p	123	2	flexible	flexible	JJ
cord-012418-6ralcn8p	123	3	structure	structure	NN
cord-012418-6ralcn8p	123	4	enables	enable	VBZ
cord-012418-6ralcn8p	123	5	the	the	DT
cord-012418-6ralcn8p	123	6	regulation	regulation	NN
cord-012418-6ralcn8p	123	7	of	of	IN
cord-012418-6ralcn8p	123	8	gene	gene	NN
cord-012418-6ralcn8p	123	9	transcription	transcription	NN
cord-012418-6ralcn8p	123	10	by	by	IN
cord-012418-6ralcn8p	123	11	integrating	integrate	VBG
cord-012418-6ralcn8p	123	12	the	the	DT
cord-012418-6ralcn8p	123	13	cues	cue	NNS
cord-012418-6ralcn8p	123	14	from	from	IN
cord-012418-6ralcn8p	123	15	several	several	JJ
cord-012418-6ralcn8p	123	16	hundred	hundred	CD
cord-012418-6ralcn8p	123	17	transcription	transcription	NN
cord-012418-6ralcn8p	123	18	factors	factor	NNS
cord-012418-6ralcn8p	123	19	,	,	,
cord-012418-6ralcn8p	123	20	yielding	yield	VBG
cord-012418-6ralcn8p	123	21	CBP	CBP	NNP
cord-012418-6ralcn8p	123	22	/	/	SYM
cord-012418-6ralcn8p	123	23	p300	p300	NNP
cord-012418-6ralcn8p	123	24	the	the	DT
cord-012418-6ralcn8p	123	25	designation	designation	NN
cord-012418-6ralcn8p	123	26	"	"	``
cord-012418-6ralcn8p	123	27	master	master	NN
cord-012418-6ralcn8p	123	28	"	"	''
cord-012418-6ralcn8p	123	29	coactivators	coactivator	NNS
cord-012418-6ralcn8p	123	30	of	of	IN
cord-012418-6ralcn8p	123	31	transcription	transcription	NN
cord-012418-6ralcn8p	123	32	.	.	.
cord-012418-6ralcn8p	124	1	The	the	DT
cord-012418-6ralcn8p	124	2	closely	closely	RB
cord-012418-6ralcn8p	124	3	related	related	JJ
cord-012418-6ralcn8p	124	4	proteins	protein	NNS
cord-012418-6ralcn8p	124	5	CBP	CBP	NNP
cord-012418-6ralcn8p	124	6	and	and	CC
cord-012418-6ralcn8p	124	7	p300	p300	NNP
cord-012418-6ralcn8p	124	8	are	be	VBP
cord-012418-6ralcn8p	124	9	usually	usually	RB
cord-012418-6ralcn8p	124	10	regarded	regard	VBN
cord-012418-6ralcn8p	124	11	as	as	IN
cord-012418-6ralcn8p	124	12	functionally	functionally	RB
cord-012418-6ralcn8p	124	13	redundant	redundant	JJ
cord-012418-6ralcn8p	124	14	-	-	:
cord-012418-6ralcn8p	124	15	thus	thus	RB
cord-012418-6ralcn8p	124	16	often	often	RB
cord-012418-6ralcn8p	124	17	referred	refer	VBN
cord-012418-6ralcn8p	124	18	to	to	IN
cord-012418-6ralcn8p	124	19	in	in	IN
cord-012418-6ralcn8p	124	20	combination	combination	NN
cord-012418-6ralcn8p	124	21	as	as	IN
cord-012418-6ralcn8p	124	22	CBP	CBP	NNP
cord-012418-6ralcn8p	124	23	/	/	SYM
cord-012418-6ralcn8p	124	24	p300-and	p300-and	NNP
cord-012418-6ralcn8p	124	25	due	due	IN
cord-012418-6ralcn8p	124	26	to	to	IN
cord-012418-6ralcn8p	124	27	this	this	DT
cord-012418-6ralcn8p	124	28	assumption	assumption	NN
cord-012418-6ralcn8p	124	29	,	,	,
cord-012418-6ralcn8p	124	30	studies	study	NNS
cord-012418-6ralcn8p	124	31	characterising	characterise	VBG
cord-012418-6ralcn8p	124	32	IRF3	IRF3	NNP
cord-012418-6ralcn8p	124	33	interactions	interaction	NNS
cord-012418-6ralcn8p	124	34	assessed	assess	VBD
cord-012418-6ralcn8p	124	35	association	association	NNP
cord-012418-6ralcn8p	124	36	of	of	IN
cord-012418-6ralcn8p	124	37	one	one	CD
cord-012418-6ralcn8p	124	38	or	or	CC
cord-012418-6ralcn8p	124	39	the	the	DT
cord-012418-6ralcn8p	124	40	other	other	JJ
cord-012418-6ralcn8p	124	41	[	[	-LRB-
cord-012418-6ralcn8p	124	42	57	57	CD
cord-012418-6ralcn8p	124	43	]	]	-RRB-
cord-012418-6ralcn8p	124	44	.	.	.
cord-012418-6ralcn8p	125	1	However	however	RB
cord-012418-6ralcn8p	125	2	,	,	,
cord-012418-6ralcn8p	125	3	there	there	EX
cord-012418-6ralcn8p	125	4	is	be	VBZ
cord-012418-6ralcn8p	125	5	growing	grow	VBG
cord-012418-6ralcn8p	125	6	evidence	evidence	NN
cord-012418-6ralcn8p	125	7	that	that	IN
cord-012418-6ralcn8p	125	8	their	-PRON-	PRP$
cord-012418-6ralcn8p	125	9	activity	activity	NN
cord-012418-6ralcn8p	125	10	is	be	VBZ
cord-012418-6ralcn8p	125	11	overlapping	overlap	VBG
cord-012418-6ralcn8p	125	12	but	but	CC
cord-012418-6ralcn8p	125	13	can	can	MD
cord-012418-6ralcn8p	125	14	be	be	VB
cord-012418-6ralcn8p	125	15	distinctly	distinctly	RB
cord-012418-6ralcn8p	125	16	involved	involve	VBN
cord-012418-6ralcn8p	125	17	in	in	IN
cord-012418-6ralcn8p	125	18	regulation	regulation	NN
cord-012418-6ralcn8p	125	19	of	of	IN
cord-012418-6ralcn8p	125	20	different	different	JJ
cord-012418-6ralcn8p	125	21	pathways	pathway	NNS
cord-012418-6ralcn8p	125	22	,	,	,
cord-012418-6ralcn8p	125	23	as	as	IN
cord-012418-6ralcn8p	125	24	exemplified	exemplify	VBN
cord-012418-6ralcn8p	125	25	by	by	IN
cord-012418-6ralcn8p	125	26	brain	brain	NN
cord-012418-6ralcn8p	125	27	development	development	NN
cord-012418-6ralcn8p	125	28	[	[	-LRB-
cord-012418-6ralcn8p	125	29	58	58	CD
cord-012418-6ralcn8p	125	30	,	,	,
cord-012418-6ralcn8p	125	31	59	59	CD
cord-012418-6ralcn8p	125	32	]	]	-RRB-
cord-012418-6ralcn8p	125	33	.	.	.
cord-012418-6ralcn8p	126	1	Considering	consider	VBG
cord-012418-6ralcn8p	126	2	that	that	IN
cord-012418-6ralcn8p	126	3	both	both	CC
cord-012418-6ralcn8p	126	4	CBP	CBP	NNP
cord-012418-6ralcn8p	126	5	and	and	CC
cord-012418-6ralcn8p	126	6	p300	p300	NNP
cord-012418-6ralcn8p	126	7	can	can	MD
cord-012418-6ralcn8p	126	8	participate	participate	VB
cord-012418-6ralcn8p	126	9	in	in	IN
cord-012418-6ralcn8p	126	10	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	126	11	formation	formation	NN
cord-012418-6ralcn8p	126	12	with	with	IN
cord-012418-6ralcn8p	126	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	126	14	but	but	CC
cord-012418-6ralcn8p	126	15	do	do	VBP
cord-012418-6ralcn8p	126	16	so	so	RB
cord-012418-6ralcn8p	126	17	with	with	IN
cord-012418-6ralcn8p	126	18	different	different	JJ
cord-012418-6ralcn8p	126	19	shares	share	NNS
cord-012418-6ralcn8p	126	20	[	[	-LRB-
cord-012418-6ralcn8p	126	21	38	38	CD
cord-012418-6ralcn8p	126	22	,	,	,
cord-012418-6ralcn8p	126	23	52	52	CD
cord-012418-6ralcn8p	126	24	]	]	-RRB-
cord-012418-6ralcn8p	126	25	,	,	,
cord-012418-6ralcn8p	126	26	it	-PRON-	PRP
cord-012418-6ralcn8p	126	27	would	would	MD
cord-012418-6ralcn8p	126	28	be	be	VB
cord-012418-6ralcn8p	126	29	interesting	interesting	JJ
cord-012418-6ralcn8p	126	30	to	to	TO
cord-012418-6ralcn8p	126	31	determine	determine	VB
cord-012418-6ralcn8p	126	32	whether	whether	IN
cord-012418-6ralcn8p	126	33	engagement	engagement	NN
cord-012418-6ralcn8p	126	34	of	of	IN
cord-012418-6ralcn8p	126	35	CBP	CBP	NNP
cord-012418-6ralcn8p	126	36	versus	versus	IN
cord-012418-6ralcn8p	126	37	p300	p300	NNP
cord-012418-6ralcn8p	126	38	is	be	VBZ
cord-012418-6ralcn8p	126	39	specific	specific	JJ
cord-012418-6ralcn8p	126	40	or	or	CC
cord-012418-6ralcn8p	126	41	coincidental	coincidental	JJ
cord-012418-6ralcn8p	126	42	.	.	.
cord-012418-6ralcn8p	127	1	Potentially	potentially	RB
cord-012418-6ralcn8p	127	2	,	,	,
cord-012418-6ralcn8p	127	3	the	the	DT
cord-012418-6ralcn8p	127	4	contribution	contribution	NN
cord-012418-6ralcn8p	127	5	of	of	IN
cord-012418-6ralcn8p	127	6	the	the	DT
cord-012418-6ralcn8p	127	7	individual	individual	JJ
cord-012418-6ralcn8p	127	8	coactivators	coactivator	NNS
cord-012418-6ralcn8p	127	9	could	could	MD
cord-012418-6ralcn8p	127	10	change	change	VB
cord-012418-6ralcn8p	127	11	during	during	IN
cord-012418-6ralcn8p	127	12	the	the	DT
cord-012418-6ralcn8p	127	13	different	different	JJ
cord-012418-6ralcn8p	127	14	phases	phase	NNS
cord-012418-6ralcn8p	127	15	of	of	IN
cord-012418-6ralcn8p	127	16	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	127	17	expression	expression	NN
cord-012418-6ralcn8p	127	18	depending	depend	VBG
cord-012418-6ralcn8p	127	19	on	on	IN
cord-012418-6ralcn8p	127	20	integrated	integrate	VBN
cord-012418-6ralcn8p	127	21	signals	signal	NNS
cord-012418-6ralcn8p	127	22	.	.	.
cord-012418-6ralcn8p	128	1	To	to	TO
cord-012418-6ralcn8p	128	2	exercise	exercise	VB
cord-012418-6ralcn8p	128	3	its	-PRON-	PRP$
cord-012418-6ralcn8p	128	4	function	function	NN
cord-012418-6ralcn8p	128	5	as	as	IN
cord-012418-6ralcn8p	128	6	a	a	DT
cord-012418-6ralcn8p	128	7	transcription	transcription	NN
cord-012418-6ralcn8p	128	8	factor	factor	NN
cord-012418-6ralcn8p	128	9	,	,	,
cord-012418-6ralcn8p	128	10	it	-PRON-	PRP
cord-012418-6ralcn8p	128	11	is	be	VBZ
cord-012418-6ralcn8p	128	12	pivotal	pivotal	JJ
cord-012418-6ralcn8p	128	13	that	that	IN
cord-012418-6ralcn8p	128	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	128	15	can	can	MD
cord-012418-6ralcn8p	128	16	reach	reach	VB
cord-012418-6ralcn8p	128	17	the	the	DT
cord-012418-6ralcn8p	128	18	nucleus	nucleus	NN
cord-012418-6ralcn8p	128	19	.	.	.
cord-012418-6ralcn8p	129	1	In	in	IN
cord-012418-6ralcn8p	129	2	fact	fact	NN
cord-012418-6ralcn8p	129	3	,	,	,
cord-012418-6ralcn8p	129	4	the	the	DT
cord-012418-6ralcn8p	129	5	latent	latent	JJ
cord-012418-6ralcn8p	129	6	protein	protein	NN
cord-012418-6ralcn8p	129	7	already	already	RB
cord-012418-6ralcn8p	129	8	shuttles	shuttle	VBZ
cord-012418-6ralcn8p	129	9	between	between	IN
cord-012418-6ralcn8p	129	10	the	the	DT
cord-012418-6ralcn8p	129	11	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	129	12	and	and	CC
cord-012418-6ralcn8p	129	13	nucleus	nucleus	NN
cord-012418-6ralcn8p	129	14	in	in	IN
cord-012418-6ralcn8p	129	15	unstimulated	unstimulated	JJ
cord-012418-6ralcn8p	129	16	conditions	condition	NNS
cord-012418-6ralcn8p	129	17	driven	drive	VBN
cord-012418-6ralcn8p	129	18	by	by	IN
cord-012418-6ralcn8p	129	19	its	-PRON-	PRP$
cord-012418-6ralcn8p	129	20	NLS	NLS	NNP
cord-012418-6ralcn8p	129	21	and	and	CC
cord-012418-6ralcn8p	129	22	NES	NES	NNP
cord-012418-6ralcn8p	129	23	.	.	.
cord-012418-6ralcn8p	130	1	As	as	IN
cord-012418-6ralcn8p	130	2	the	the	DT
cord-012418-6ralcn8p	130	3	influence	influence	NN
cord-012418-6ralcn8p	130	4	of	of	IN
cord-012418-6ralcn8p	130	5	the	the	DT
cord-012418-6ralcn8p	130	6	NES	NES	NNP
cord-012418-6ralcn8p	130	7	seems	seem	VBZ
cord-012418-6ralcn8p	130	8	to	to	TO
cord-012418-6ralcn8p	130	9	prevail	prevail	VB
cord-012418-6ralcn8p	130	10	the	the	DT
cord-012418-6ralcn8p	130	11	import	import	NN
cord-012418-6ralcn8p	130	12	,	,	,
cord-012418-6ralcn8p	130	13	the	the	DT
cord-012418-6ralcn8p	130	14	main	main	JJ
cord-012418-6ralcn8p	130	15	share	share	NN
cord-012418-6ralcn8p	130	16	of	of	IN
cord-012418-6ralcn8p	130	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	130	18	molecules	molecule	NNS
cord-012418-6ralcn8p	130	19	localises	localise	NNS
cord-012418-6ralcn8p	130	20	to	to	IN
cord-012418-6ralcn8p	130	21	the	the	DT
cord-012418-6ralcn8p	130	22	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	130	23	[	[	-LRB-
cord-012418-6ralcn8p	130	24	22	22	CD
cord-012418-6ralcn8p	130	25	]	]	-RRB-
cord-012418-6ralcn8p	130	26	.	.	.
cord-012418-6ralcn8p	131	1	The	the	DT
cord-012418-6ralcn8p	131	2	constitutive	constitutive	JJ
cord-012418-6ralcn8p	131	3	export	export	NN
cord-012418-6ralcn8p	131	4	of	of	IN
cord-012418-6ralcn8p	131	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	131	6	was	be	VBD
cord-012418-6ralcn8p	131	7	shown	show	VBN
cord-012418-6ralcn8p	131	8	to	to	TO
cord-012418-6ralcn8p	131	9	involve	involve	VB
cord-012418-6ralcn8p	131	10	exportin	exportin	NN
cord-012418-6ralcn8p	131	11	1	1	CD
cord-012418-6ralcn8p	131	12	(	(	-LRB-
cord-012418-6ralcn8p	131	13	CRM1	CRM1	NNP
cord-012418-6ralcn8p	131	14	)	)	-RRB-
cord-012418-6ralcn8p	132	1	[	[	-LRB-
cord-012418-6ralcn8p	132	2	21	21	CD
cord-012418-6ralcn8p	132	3	,	,	,
cord-012418-6ralcn8p	132	4	22	22	CD
cord-012418-6ralcn8p	132	5	]	]	-RRB-
cord-012418-6ralcn8p	132	6	,	,	,
cord-012418-6ralcn8p	132	7	and	and	CC
cord-012418-6ralcn8p	132	8	the	the	DT
cord-012418-6ralcn8p	132	9	import	import	NN
cord-012418-6ralcn8p	132	10	through	through	IN
cord-012418-6ralcn8p	132	11	nuclear	nuclear	JJ
cord-012418-6ralcn8p	132	12	pore	pore	NN
cord-012418-6ralcn8p	132	13	complexes	complex	NNS
cord-012418-6ralcn8p	132	14	involves	involve	VBZ
cord-012418-6ralcn8p	132	15	the	the	DT
cord-012418-6ralcn8p	132	16	importins	importins	NNP
cord-012418-6ralcn8p	132	17	karyopherin	karyopherin	NNP
cord-012418-6ralcn8p	132	18	(	(	-LRB-
cord-012418-6ralcn8p	132	19	KPN	KPN	NNP
cord-012418-6ralcn8p	132	20	)	)	-RRB-
cord-012418-6ralcn8p	132	21	subunit	subunit	NN
cord-012418-6ralcn8p	132	22	α2	α2	NNP
cord-012418-6ralcn8p	132	23	(	(	-LRB-
cord-012418-6ralcn8p	132	24	KPNA2	KPNA2	NNP
cord-012418-6ralcn8p	132	25	)	)	-RRB-
cord-012418-6ralcn8p	132	26	,	,	.
cord-012418-6ralcn8p	133	1	KPNA3	KPNA3	NNP
cord-012418-6ralcn8p	133	2	and	and	CC
cord-012418-6ralcn8p	133	3	KPNA4	KPNA4	NNP
cord-012418-6ralcn8p	133	4	(	(	-LRB-
cord-012418-6ralcn8p	133	5	or	or	CC
cord-012418-6ralcn8p	133	6	Qip1	Qip1	NNP
cord-012418-6ralcn8p	133	7	)	)	-RRB-
cord-012418-6ralcn8p	134	1	[	[	-LRB-
cord-012418-6ralcn8p	134	2	22	22	CD
cord-012418-6ralcn8p	134	3	,	,	,
cord-012418-6ralcn8p	134	4	60	60	CD
cord-012418-6ralcn8p	134	5	]	]	-RRB-
cord-012418-6ralcn8p	134	6	.	.	.
cord-012418-6ralcn8p	135	1	Upon	upon	IN
cord-012418-6ralcn8p	135	2	infection	infection	NN
cord-012418-6ralcn8p	135	3	,	,	,
cord-012418-6ralcn8p	135	4	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	135	5	of	of	IN
cord-012418-6ralcn8p	135	6	the	the	DT
cord-012418-6ralcn8p	135	7	AIE	aie	NN
cord-012418-6ralcn8p	135	8	and	and	CC
cord-012418-6ralcn8p	135	9	accompanying	accompany	VBG
cord-012418-6ralcn8p	135	10	structural	structural	JJ
cord-012418-6ralcn8p	135	11	rearrangements	rearrangement	NNS
cord-012418-6ralcn8p	135	12	enable	enable	VBP
cord-012418-6ralcn8p	135	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	135	14	to	to	TO
cord-012418-6ralcn8p	135	15	associate	associate	VB
cord-012418-6ralcn8p	135	16	with	with	IN
cord-012418-6ralcn8p	135	17	CBP	CBP	NNP
cord-012418-6ralcn8p	135	18	,	,	,
cord-012418-6ralcn8p	135	19	and	and	CC
cord-012418-6ralcn8p	135	20	this	this	DT
cord-012418-6ralcn8p	135	21	interaction	interaction	NN
cord-012418-6ralcn8p	135	22	retains	retain	VBZ
cord-012418-6ralcn8p	135	23	the	the	DT
cord-012418-6ralcn8p	135	24	activated	activate	VBN
cord-012418-6ralcn8p	135	25	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	135	26	in	in	IN
cord-012418-6ralcn8p	135	27	the	the	DT
cord-012418-6ralcn8p	135	28	nucleus	nucleus	NN
cord-012418-6ralcn8p	135	29	[	[	-LRB-
cord-012418-6ralcn8p	135	30	22	22	CD
cord-012418-6ralcn8p	135	31	]	]	-RRB-
cord-012418-6ralcn8p	135	32	.	.	.
cord-012418-6ralcn8p	136	1	Interestingly	interestingly	RB
cord-012418-6ralcn8p	136	2	,	,	,
cord-012418-6ralcn8p	136	3	in	in	IN
cord-012418-6ralcn8p	136	4	vitro	vitro	FW
cord-012418-6ralcn8p	136	5	experiments	experiment	NNS
cord-012418-6ralcn8p	136	6	from	from	IN
cord-012418-6ralcn8p	136	7	several	several	JJ
cord-012418-6ralcn8p	136	8	groups	group	NNS
cord-012418-6ralcn8p	136	9	analysing	analyse	VBG
cord-012418-6ralcn8p	136	10	the	the	DT
cord-012418-6ralcn8p	136	11	interaction	interaction	NN
cord-012418-6ralcn8p	136	12	between	between	IN
cord-012418-6ralcn8p	136	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	136	14	and	and	CC
cord-012418-6ralcn8p	136	15	the	the	DT
cord-012418-6ralcn8p	136	16	IRF	IRF	NNP
cord-012418-6ralcn8p	136	17	-	-	HYPH
cord-012418-6ralcn8p	136	18	binding	bind	VBG
cord-012418-6ralcn8p	136	19	domain	domain	NN
cord-012418-6ralcn8p	136	20	(	(	-LRB-
cord-012418-6ralcn8p	136	21	IBiD	ibid	JJ
cord-012418-6ralcn8p	136	22	)	)	-RRB-
cord-012418-6ralcn8p	136	23	in	in	IN
cord-012418-6ralcn8p	136	24	the	the	DT
cord-012418-6ralcn8p	136	25	C	c	NN
cord-012418-6ralcn8p	136	26	-	-	HYPH
cord-012418-6ralcn8p	136	27	terminus	terminus	NN
cord-012418-6ralcn8p	136	28	of	of	IN
cord-012418-6ralcn8p	136	29	CBP	CBP	NNP
cord-012418-6ralcn8p	136	30	have	have	VBP
cord-012418-6ralcn8p	136	31	shown	show	VBN
cord-012418-6ralcn8p	136	32	that	that	IN
cord-012418-6ralcn8p	136	33	independently	independently	RB
cord-012418-6ralcn8p	136	34	of	of	IN
cord-012418-6ralcn8p	136	35	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	136	36	,	,	,
cord-012418-6ralcn8p	136	37	monomeric	monomeric	JJ
cord-012418-6ralcn8p	136	38	IRF3	IRF3	NNP
cord-012418-6ralcn8p	136	39	can	can	MD
cord-012418-6ralcn8p	136	40	interact	interact	VB
cord-012418-6ralcn8p	136	41	with	with	IN
cord-012418-6ralcn8p	136	42	CBP	CBP	NNP
cord-012418-6ralcn8p	136	43	once	once	RB
cord-012418-6ralcn8p	136	44	the	the	DT
cord-012418-6ralcn8p	136	45	auto	auto	NN
cord-012418-6ralcn8p	136	46	-	-	HYPH
cord-012418-6ralcn8p	136	47	inhibition	inhibition	NN
cord-012418-6ralcn8p	136	48	is	be	VBZ
cord-012418-6ralcn8p	136	49	relieved	relieve	VBN
cord-012418-6ralcn8p	136	50	[	[	-LRB-
cord-012418-6ralcn8p	136	51	22	22	CD
cord-012418-6ralcn8p	136	52	,	,	,
cord-012418-6ralcn8p	136	53	45	45	CD
cord-012418-6ralcn8p	136	54	,	,	,
cord-012418-6ralcn8p	136	55	46	46	CD
cord-012418-6ralcn8p	136	56	,	,	,
cord-012418-6ralcn8p	136	57	51	51	CD
cord-012418-6ralcn8p	136	58	]	]	-RRB-
cord-012418-6ralcn8p	136	59	.	.	.
cord-012418-6ralcn8p	137	1	Moreover	moreover	RB
cord-012418-6ralcn8p	137	2	,	,	,
cord-012418-6ralcn8p	137	3	in	in	IN
cord-012418-6ralcn8p	137	4	vitro	vitro	FW
cord-012418-6ralcn8p	137	5	analyses	analysis	NNS
cord-012418-6ralcn8p	137	6	by	by	IN
cord-012418-6ralcn8p	137	7	Chen	Chen	NNP
cord-012418-6ralcn8p	137	8	and	and	CC
cord-012418-6ralcn8p	137	9	colleagues	colleague	NNS
cord-012418-6ralcn8p	137	10	implied	imply	VBD
cord-012418-6ralcn8p	137	11	that	that	IN
cord-012418-6ralcn8p	137	12	the	the	DT
cord-012418-6ralcn8p	137	13	presence	presence	NN
cord-012418-6ralcn8p	137	14	of	of	IN
cord-012418-6ralcn8p	137	15	CBP	CBP	NNP
cord-012418-6ralcn8p	137	16	promotes	promote	VBZ
cord-012418-6ralcn8p	137	17	oligomerisation	oligomerisation	NN
cord-012418-6ralcn8p	137	18	of	of	IN
cord-012418-6ralcn8p	137	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	137	20	molecules	molecule	NNS
cord-012418-6ralcn8p	137	21	with	with	IN
cord-012418-6ralcn8p	137	22	the	the	DT
cord-012418-6ralcn8p	137	23	required	require	VBN
cord-012418-6ralcn8p	137	24	phosphomimetic	phosphomimetic	JJ
cord-012418-6ralcn8p	137	25	mutations	mutation	NNS
cord-012418-6ralcn8p	137	26	that	that	WDT
cord-012418-6ralcn8p	137	27	enable	enable	VBP
cord-012418-6ralcn8p	137	28	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	137	29	,	,	,
cord-012418-6ralcn8p	137	30	while	while	IN
cord-012418-6ralcn8p	137	31	the	the	DT
cord-012418-6ralcn8p	137	32	mutant	mutant	JJ
cord-012418-6ralcn8p	137	33	proteins	protein	NNS
cord-012418-6ralcn8p	137	34	stayed	stay	VBD
cord-012418-6ralcn8p	137	35	monomeric	monomeric	JJ
cord-012418-6ralcn8p	137	36	without	without	IN
cord-012418-6ralcn8p	137	37	CBP	CBP	NNP
cord-012418-6ralcn8p	137	38	[	[	-LRB-
cord-012418-6ralcn8p	137	39	51	51	CD
cord-012418-6ralcn8p	137	40	]	]	-RRB-
cord-012418-6ralcn8p	137	41	.	.	.
cord-012418-6ralcn8p	138	1	In	in	IN
cord-012418-6ralcn8p	138	2	a	a	DT
cord-012418-6ralcn8p	138	3	cellular	cellular	JJ
cord-012418-6ralcn8p	138	4	scenario	scenario	NN
cord-012418-6ralcn8p	138	5	wherein	wherein	WRB
cord-012418-6ralcn8p	138	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	138	7	dimerises	dimerise	VBZ
cord-012418-6ralcn8p	138	8	directly	directly	RB
cord-012418-6ralcn8p	138	9	after	after	IN
cord-012418-6ralcn8p	138	10	acquiring	acquire	VBG
cord-012418-6ralcn8p	138	11	the	the	DT
cord-012418-6ralcn8p	138	12	required	require	VBN
cord-012418-6ralcn8p	138	13	modifications	modification	NNS
cord-012418-6ralcn8p	138	14	in	in	IN
cord-012418-6ralcn8p	138	15	the	the	DT
cord-012418-6ralcn8p	138	16	vicinity	vicinity	NN
cord-012418-6ralcn8p	138	17	of	of	IN
cord-012418-6ralcn8p	138	18	the	the	DT
cord-012418-6ralcn8p	138	19	adaptor	adaptor	NN
cord-012418-6ralcn8p	138	20	platform	platform	NN
cord-012418-6ralcn8p	138	21	in	in	IN
cord-012418-6ralcn8p	138	22	the	the	DT
cord-012418-6ralcn8p	138	23	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	138	24	,	,	,
cord-012418-6ralcn8p	138	25	this	this	DT
cord-012418-6ralcn8p	138	26	interaction	interaction	NN
cord-012418-6ralcn8p	138	27	might	may	MD
cord-012418-6ralcn8p	138	28	not	not	RB
cord-012418-6ralcn8p	138	29	be	be	VB
cord-012418-6ralcn8p	138	30	relevant	relevant	JJ
cord-012418-6ralcn8p	138	31	,	,	,
cord-012418-6ralcn8p	138	32	though	though	RB
cord-012418-6ralcn8p	138	33	.	.	.
cord-012418-6ralcn8p	139	1	Characterisation	Characterisation	NNP
cord-012418-6ralcn8p	139	2	of	of	IN
cord-012418-6ralcn8p	139	3	the	the	DT
cord-012418-6ralcn8p	139	4	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	139	5	demonstrated	demonstrate	VBD
cord-012418-6ralcn8p	139	6	that	that	IN
cord-012418-6ralcn8p	139	7	the	the	DT
cord-012418-6ralcn8p	139	8	homodimer	homodimer	NN
cord-012418-6ralcn8p	139	9	of	of	IN
cord-012418-6ralcn8p	139	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	139	11	is	be	VBZ
cord-012418-6ralcn8p	139	12	more	more	RBR
cord-012418-6ralcn8p	139	13	stable	stable	JJ
cord-012418-6ralcn8p	139	14	than	than	IN
cord-012418-6ralcn8p	139	15	the	the	DT
cord-012418-6ralcn8p	139	16	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	139	17	of	of	IN
cord-012418-6ralcn8p	139	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	139	19	dimer	dimer	NN
cord-012418-6ralcn8p	139	20	plus	plus	CC
cord-012418-6ralcn8p	139	21	p300	p300	NNP
cord-012418-6ralcn8p	139	22	[	[	-LRB-
cord-012418-6ralcn8p	139	23	53	53	CD
cord-012418-6ralcn8p	139	24	]	]	-RRB-
cord-012418-6ralcn8p	139	25	,	,	,
cord-012418-6ralcn8p	139	26	and	and	CC
cord-012418-6ralcn8p	139	27	the	the	DT
cord-012418-6ralcn8p	139	28	association	association	NN
cord-012418-6ralcn8p	139	29	of	of	IN
cord-012418-6ralcn8p	139	30	IRF3	IRF3	NNP
cord-012418-6ralcn8p	139	31	dimers	dimer	NNS
cord-012418-6ralcn8p	139	32	with	with	IN
cord-012418-6ralcn8p	139	33	CBP	CBP	NNP
cord-012418-6ralcn8p	139	34	is	be	VBZ
cord-012418-6ralcn8p	139	35	stronger	strong	JJR
cord-012418-6ralcn8p	139	36	than	than	IN
cord-012418-6ralcn8p	139	37	that	that	DT
cord-012418-6ralcn8p	139	38	of	of	IN
cord-012418-6ralcn8p	139	39	monomeric	monomeric	JJ
cord-012418-6ralcn8p	139	40	IRF3	IRF3	NNP
cord-012418-6ralcn8p	139	41	[	[	-LRB-
cord-012418-6ralcn8p	139	42	51	51	CD
cord-012418-6ralcn8p	139	43	]	]	-RRB-
cord-012418-6ralcn8p	139	44	,	,	,
cord-012418-6ralcn8p	139	45	Viruses	virus	NNS
cord-012418-6ralcn8p	139	46	2020	2020	CD
cord-012418-6ralcn8p	139	47	,	,	,
cord-012418-6ralcn8p	139	48	12	12	CD
cord-012418-6ralcn8p	139	49	,	,	,
cord-012418-6ralcn8p	139	50	733	733	CD
cord-012418-6ralcn8p	139	51	7	7	CD
cord-012418-6ralcn8p	139	52	of	of	IN
cord-012418-6ralcn8p	139	53	33	33	CD
cord-012418-6ralcn8p	139	54	favouring	favour	VBG
cord-012418-6ralcn8p	139	55	a	a	DT
cord-012418-6ralcn8p	139	56	model	model	NN
cord-012418-6ralcn8p	139	57	wherein	wherein	WRB
cord-012418-6ralcn8p	139	58	IRF3	IRF3	NNP
cord-012418-6ralcn8p	139	59	first	first	JJ
cord-012418-6ralcn8p	139	60	dimerises	dimerise	NNS
cord-012418-6ralcn8p	139	61	,	,	,
cord-012418-6ralcn8p	139	62	and	and	CC
cord-012418-6ralcn8p	139	63	dimers	dimer	NNS
cord-012418-6ralcn8p	139	64	subsequently	subsequently	RB
cord-012418-6ralcn8p	139	65	interact	interact	VBP
cord-012418-6ralcn8p	139	66	with	with	IN
cord-012418-6ralcn8p	139	67	CBP	CBP	NNP
cord-012418-6ralcn8p	139	68	.	.	.
cord-012418-6ralcn8p	140	1	However	however	RB
cord-012418-6ralcn8p	140	2	,	,	,
cord-012418-6ralcn8p	140	3	without	without	IN
cord-012418-6ralcn8p	140	4	determination	determination	NN
cord-012418-6ralcn8p	140	5	of	of	IN
cord-012418-6ralcn8p	140	6	the	the	DT
cord-012418-6ralcn8p	140	7	precise	precise	JJ
cord-012418-6ralcn8p	140	8	temporal	temporal	JJ
cord-012418-6ralcn8p	140	9	succession	succession	NN
cord-012418-6ralcn8p	140	10	of	of	IN
cord-012418-6ralcn8p	140	11	interactions	interaction	NNS
cord-012418-6ralcn8p	140	12	,	,	,
cord-012418-6ralcn8p	140	13	this	this	DT
cord-012418-6ralcn8p	140	14	leaves	leave	VBZ
cord-012418-6ralcn8p	140	15	the	the	DT
cord-012418-6ralcn8p	140	16	possibility	possibility	NN
cord-012418-6ralcn8p	140	17	that	that	IN
cord-012418-6ralcn8p	140	18	a	a	DT
cord-012418-6ralcn8p	140	19	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	140	20	IRF3	IRF3	NNP
cord-012418-6ralcn8p	140	21	monomer	monomer	NN
cord-012418-6ralcn8p	140	22	enters	enter	VBZ
cord-012418-6ralcn8p	140	23	the	the	DT
cord-012418-6ralcn8p	140	24	nucleus	nucleus	NN
cord-012418-6ralcn8p	140	25	and	and	CC
cord-012418-6ralcn8p	140	26	interacts	interact	VBZ
cord-012418-6ralcn8p	140	27	with	with	IN
cord-012418-6ralcn8p	140	28	CBP	CBP	NNP
cord-012418-6ralcn8p	140	29	/	/	SYM
cord-012418-6ralcn8p	140	30	p300	p300	NNP
cord-012418-6ralcn8p	140	31	before	before	IN
cord-012418-6ralcn8p	140	32	it	-PRON-	PRP
cord-012418-6ralcn8p	140	33	encounters	encounter	VBZ
cord-012418-6ralcn8p	140	34	a	a	DT
cord-012418-6ralcn8p	140	35	second	second	JJ
cord-012418-6ralcn8p	140	36	IRF3	IRF3	NNP
cord-012418-6ralcn8p	140	37	molecule	molecule	NN
cord-012418-6ralcn8p	140	38	to	to	IN
cord-012418-6ralcn8p	140	39	dimerise	dimerise	VB
cord-012418-6ralcn8p	140	40	and	and	CC
cord-012418-6ralcn8p	140	41	swiftly	swiftly	RB
cord-012418-6ralcn8p	140	42	induce	induce	VB
cord-012418-6ralcn8p	140	43	a	a	DT
cord-012418-6ralcn8p	140	44	response	response	NN
cord-012418-6ralcn8p	140	45	,	,	,
cord-012418-6ralcn8p	140	46	as	as	IN
cord-012418-6ralcn8p	140	47	suggested	suggest	VBN
cord-012418-6ralcn8p	140	48	before	before	IN
cord-012418-6ralcn8p	140	49	[	[	-LRB-
cord-012418-6ralcn8p	140	50	38	38	CD
cord-012418-6ralcn8p	140	51	]	]	-RRB-
cord-012418-6ralcn8p	140	52	.	.	.
cord-012418-6ralcn8p	141	1	In	in	IN
cord-012418-6ralcn8p	141	2	the	the	DT
cord-012418-6ralcn8p	141	3	end	end	NN
cord-012418-6ralcn8p	141	4	,	,	,
cord-012418-6ralcn8p	141	5	the	the	DT
cord-012418-6ralcn8p	141	6	coactivator	coactivator	NN
cord-012418-6ralcn8p	141	7	needs	need	VBZ
cord-012418-6ralcn8p	141	8	to	to	TO
cord-012418-6ralcn8p	141	9	associate	associate	VB
cord-012418-6ralcn8p	141	10	with	with	IN
cord-012418-6ralcn8p	141	11	dimeric	dimeric	JJ
cord-012418-6ralcn8p	141	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	141	13	because	because	IN
cord-012418-6ralcn8p	141	14	only	only	RB
cord-012418-6ralcn8p	141	15	this	this	DT
cord-012418-6ralcn8p	141	16	can	can	MD
cord-012418-6ralcn8p	141	17	induce	induce	VB
cord-012418-6ralcn8p	141	18	activation	activation	NN
cord-012418-6ralcn8p	141	19	of	of	IN
cord-012418-6ralcn8p	141	20	the	the	DT
cord-012418-6ralcn8p	141	21	KAT	KAT	NNP
cord-012418-6ralcn8p	141	22	activity	activity	NN
cord-012418-6ralcn8p	141	23	that	that	WDT
cord-012418-6ralcn8p	141	24	is	be	VBZ
cord-012418-6ralcn8p	141	25	later	later	RB
cord-012418-6ralcn8p	141	26	required	require	VBN
cord-012418-6ralcn8p	141	27	for	for	IN
cord-012418-6ralcn8p	141	28	assembly	assembly	NN
cord-012418-6ralcn8p	141	29	of	of	IN
cord-012418-6ralcn8p	141	30	the	the	DT
cord-012418-6ralcn8p	141	31	pre	pre	JJ
cord-012418-6ralcn8p	141	32	-	-	NN
cord-012418-6ralcn8p	141	33	initiation	initiation	JJ
cord-012418-6ralcn8p	141	34	complex	complex	NN
cord-012418-6ralcn8p	141	35	,	,	,
cord-012418-6ralcn8p	141	36	as	as	IN
cord-012418-6ralcn8p	141	37	demonstrated	demonstrate	VBN
cord-012418-6ralcn8p	141	38	for	for	IN
cord-012418-6ralcn8p	141	39	p300	p300	NNP
cord-012418-6ralcn8p	141	40	[	[	-LRB-
cord-012418-6ralcn8p	141	41	61	61	CD
cord-012418-6ralcn8p	141	42	]	]	-RRB-
cord-012418-6ralcn8p	141	43	.	.	.
cord-012418-6ralcn8p	142	1	Several	several	JJ
cord-012418-6ralcn8p	142	2	groups	group	NNS
cord-012418-6ralcn8p	142	3	noted	note	VBD
cord-012418-6ralcn8p	142	4	exceptions	exception	NNS
cord-012418-6ralcn8p	142	5	to	to	IN
cord-012418-6ralcn8p	142	6	the	the	DT
cord-012418-6ralcn8p	142	7	common	common	JJ
cord-012418-6ralcn8p	142	8	model	model	NN
cord-012418-6ralcn8p	142	9	of	of	IN
cord-012418-6ralcn8p	142	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	142	11	activation	activation	NN
cord-012418-6ralcn8p	142	12	followed	follow	VBD
cord-012418-6ralcn8p	142	13	above	above	RB
cord-012418-6ralcn8p	142	14	,	,	,
cord-012418-6ralcn8p	142	15	drawing	draw	VBG
cord-012418-6ralcn8p	142	16	attention	attention	NN
cord-012418-6ralcn8p	142	17	to	to	IN
cord-012418-6ralcn8p	142	18	the	the	DT
cord-012418-6ralcn8p	142	19	fact	fact	NN
cord-012418-6ralcn8p	142	20	that	that	IN
cord-012418-6ralcn8p	142	21	assessment	assessment	NN
cord-012418-6ralcn8p	142	22	of	of	IN
cord-012418-6ralcn8p	142	23	the	the	DT
cord-012418-6ralcn8p	142	24	conventional	conventional	JJ
cord-012418-6ralcn8p	142	25	signs	sign	NNS
cord-012418-6ralcn8p	142	26	like	like	IN
cord-012418-6ralcn8p	142	27	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	142	28	that	that	WDT
cord-012418-6ralcn8p	142	29	reflect	reflect	VBP
cord-012418-6ralcn8p	142	30	the	the	DT
cord-012418-6ralcn8p	142	31	intermediate	intermediate	JJ
cord-012418-6ralcn8p	142	32	states	state	NNS
cord-012418-6ralcn8p	142	33	is	be	VBZ
cord-012418-6ralcn8p	142	34	not	not	RB
cord-012418-6ralcn8p	142	35	always	always	RB
cord-012418-6ralcn8p	142	36	sufficient	sufficient	JJ
cord-012418-6ralcn8p	142	37	to	to	TO
cord-012418-6ralcn8p	142	38	infer	infer	VB
cord-012418-6ralcn8p	142	39	on	on	IN
cord-012418-6ralcn8p	142	40	the	the	DT
cord-012418-6ralcn8p	142	41	downstream	downstream	JJ
cord-012418-6ralcn8p	142	42	biological	biological	JJ
cord-012418-6ralcn8p	142	43	response	response	NN
cord-012418-6ralcn8p	142	44	[	[	-LRB-
cord-012418-6ralcn8p	142	45	48	48	CD
cord-012418-6ralcn8p	142	46	,	,	,
cord-012418-6ralcn8p	142	47	62	62	CD
cord-012418-6ralcn8p	142	48	,	,	,
cord-012418-6ralcn8p	142	49	63	63	CD
cord-012418-6ralcn8p	142	50	]	]	-RRB-
cord-012418-6ralcn8p	142	51	.	.	.
cord-012418-6ralcn8p	143	1	Due	due	IN
cord-012418-6ralcn8p	143	2	to	to	IN
cord-012418-6ralcn8p	143	3	these	these	DT
cord-012418-6ralcn8p	143	4	discrepancies	discrepancy	NNS
cord-012418-6ralcn8p	143	5	we	-PRON-	PRP
cord-012418-6ralcn8p	143	6	suggest	suggest	VBP
cord-012418-6ralcn8p	143	7	to	to	TO
cord-012418-6ralcn8p	143	8	differentiate	differentiate	VB
cord-012418-6ralcn8p	143	9	between	between	IN
cord-012418-6ralcn8p	143	10	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	143	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	143	12	that	that	WDT
cord-012418-6ralcn8p	143	13	is	be	VBZ
cord-012418-6ralcn8p	143	14	relieved	relieve	VBN
cord-012418-6ralcn8p	143	15	of	of	IN
cord-012418-6ralcn8p	143	16	the	the	DT
cord-012418-6ralcn8p	143	17	auto	auto	NN
cord-012418-6ralcn8p	143	18	-	-	HYPH
cord-012418-6ralcn8p	143	19	inhibition	inhibition	NN
cord-012418-6ralcn8p	143	20	and	and	CC
cord-012418-6ralcn8p	143	21	can	can	MD
cord-012418-6ralcn8p	143	22	"	"	``
cord-012418-6ralcn8p	143	23	actively	actively	RB
cord-012418-6ralcn8p	143	24	"	"	''
cord-012418-6ralcn8p	143	25	participate	participate	VB
cord-012418-6ralcn8p	143	26	in	in	IN
cord-012418-6ralcn8p	143	27	subsequent	subsequent	JJ
cord-012418-6ralcn8p	143	28	steps	step	NNS
cord-012418-6ralcn8p	143	29	and	and	CC
cord-012418-6ralcn8p	143	30	IRF3	IRF3	NNP
cord-012418-6ralcn8p	143	31	in	in	IN
cord-012418-6ralcn8p	143	32	the	the	DT
cord-012418-6ralcn8p	143	33	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	143	34	that	that	WDT
cord-012418-6ralcn8p	143	35	can	can	MD
cord-012418-6ralcn8p	143	36	exercise	exercise	VB
cord-012418-6ralcn8p	143	37	its	-PRON-	PRP$
cord-012418-6ralcn8p	143	38	trans	trans	JJ
cord-012418-6ralcn8p	143	39	-	-	JJ
cord-012418-6ralcn8p	143	40	activation	activation	JJ
cord-012418-6ralcn8p	143	41	potential	potential	NN
cord-012418-6ralcn8p	143	42	as	as	IN
cord-012418-6ralcn8p	143	43	a	a	DT
cord-012418-6ralcn8p	143	44	transcription	transcription	NN
cord-012418-6ralcn8p	143	45	factor	factor	NN
cord-012418-6ralcn8p	143	46	to	to	IN
cord-012418-6ralcn8p	143	47	"	"	``
cord-012418-6ralcn8p	143	48	actively	actively	RB
cord-012418-6ralcn8p	143	49	"	"	''
cord-012418-6ralcn8p	143	50	induce	induce	VB
cord-012418-6ralcn8p	143	51	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	143	52	expression	expression	NN
cord-012418-6ralcn8p	143	53	.	.	.
cord-012418-6ralcn8p	144	1	In	in	IN
cord-012418-6ralcn8p	144	2	fact	fact	NN
cord-012418-6ralcn8p	144	3	,	,	,
cord-012418-6ralcn8p	144	4	some	some	DT
cord-012418-6ralcn8p	144	5	of	of	IN
cord-012418-6ralcn8p	144	6	these	these	DT
cord-012418-6ralcn8p	144	7	studies	study	NNS
cord-012418-6ralcn8p	144	8	assessed	assess	VBD
cord-012418-6ralcn8p	144	9	the	the	DT
cord-012418-6ralcn8p	144	10	activity	activity	NN
cord-012418-6ralcn8p	144	11	of	of	IN
cord-012418-6ralcn8p	144	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	144	13	in	in	IN
cord-012418-6ralcn8p	144	14	terms	term	NNS
cord-012418-6ralcn8p	144	15	of	of	IN
cord-012418-6ralcn8p	144	16	induction	induction	NN
cord-012418-6ralcn8p	144	17	of	of	IN
cord-012418-6ralcn8p	144	18	ISG56	ISG56	NNP
cord-012418-6ralcn8p	144	19	[	[	-LRB-
cord-012418-6ralcn8p	144	20	48	48	CD
cord-012418-6ralcn8p	144	21	,	,	,
cord-012418-6ralcn8p	144	22	62	62	CD
cord-012418-6ralcn8p	144	23	]	]	-RRB-
cord-012418-6ralcn8p	144	24	,	,	,
cord-012418-6ralcn8p	144	25	which	which	WDT
cord-012418-6ralcn8p	144	26	intermingles	intermingle	VBZ
cord-012418-6ralcn8p	144	27	the	the	DT
cord-012418-6ralcn8p	144	28	IRF3-dependent	IRF3-dependent	NNP
cord-012418-6ralcn8p	144	29	regulation	regulation	NN
cord-012418-6ralcn8p	144	30	of	of	IN
cord-012418-6ralcn8p	144	31	type	type	NN
cord-012418-6ralcn8p	144	32	I	-PRON-	PRP
cord-012418-6ralcn8p	144	33	IFNs	ifns	VBP
cord-012418-6ralcn8p	144	34	with	with	IN
cord-012418-6ralcn8p	144	35	directly	directly	RB
cord-012418-6ralcn8p	144	36	IRF3-regulated	irf3-regulate	VBN
cord-012418-6ralcn8p	144	37	ISG	ISG	NNP
cord-012418-6ralcn8p	144	38	expression	expression	NN
cord-012418-6ralcn8p	144	39	[	[	-LRB-
cord-012418-6ralcn8p	144	40	64	64	CD
cord-012418-6ralcn8p	144	41	]	]	-RRB-
cord-012418-6ralcn8p	144	42	.	.	.
cord-012418-6ralcn8p	145	1	To	to	IN
cord-012418-6ralcn8p	145	2	our	-PRON-	PRP$
cord-012418-6ralcn8p	145	3	knowledge	knowledge	NN
cord-012418-6ralcn8p	145	4	,	,	,
cord-012418-6ralcn8p	145	5	it	-PRON-	PRP
cord-012418-6ralcn8p	145	6	remains	remain	VBZ
cord-012418-6ralcn8p	145	7	to	to	TO
cord-012418-6ralcn8p	145	8	be	be	VB
cord-012418-6ralcn8p	145	9	determined	determine	VBN
cord-012418-6ralcn8p	145	10	whether	whether	IN
cord-012418-6ralcn8p	145	11	the	the	DT
cord-012418-6ralcn8p	145	12	form	form	NN
cord-012418-6ralcn8p	145	13	of	of	IN
cord-012418-6ralcn8p	145	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	145	15	induced	induce	VBN
cord-012418-6ralcn8p	145	16	for	for	IN
cord-012418-6ralcn8p	145	17	up	up	IN
cord-012418-6ralcn8p	145	18	-	-	HYPH
cord-012418-6ralcn8p	145	19	regulation	regulation	NN
cord-012418-6ralcn8p	145	20	of	of	IN
cord-012418-6ralcn8p	145	21	specific	specific	JJ
cord-012418-6ralcn8p	145	22	ISG	ISG	NNP
cord-012418-6ralcn8p	145	23	promoters	promoter	NNS
cord-012418-6ralcn8p	145	24	is	be	VBZ
cord-012418-6ralcn8p	145	25	the	the	DT
cord-012418-6ralcn8p	145	26	same	same	JJ
cord-012418-6ralcn8p	145	27	as	as	IN
cord-012418-6ralcn8p	145	28	the	the	DT
cord-012418-6ralcn8p	145	29	form	form	NN
cord-012418-6ralcn8p	145	30	of	of	IN
cord-012418-6ralcn8p	145	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	145	32	able	able	JJ
cord-012418-6ralcn8p	145	33	to	to	TO
cord-012418-6ralcn8p	145	34	induce	induce	VB
cord-012418-6ralcn8p	145	35	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	145	36	expression	expression	NN
cord-012418-6ralcn8p	145	37	.	.	.
cord-012418-6ralcn8p	146	1	Moreover	moreover	RB
cord-012418-6ralcn8p	146	2	,	,	,
cord-012418-6ralcn8p	146	3	reports	report	NNS
cord-012418-6ralcn8p	146	4	clearly	clearly	RB
cord-012418-6ralcn8p	146	5	reflect	reflect	VBP
cord-012418-6ralcn8p	146	6	that	that	IN
cord-012418-6ralcn8p	146	7	there	there	EX
cord-012418-6ralcn8p	146	8	are	be	VBP
cord-012418-6ralcn8p	146	9	different	different	JJ
cord-012418-6ralcn8p	146	10	extents	extent	NNS
cord-012418-6ralcn8p	146	11	of	of	IN
cord-012418-6ralcn8p	146	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	146	13	activity	activity	NN
cord-012418-6ralcn8p	146	14	,	,	,
cord-012418-6ralcn8p	146	15	and	and	CC
cord-012418-6ralcn8p	146	16	the	the	DT
cord-012418-6ralcn8p	146	17	protein	protein	NN
cord-012418-6ralcn8p	146	18	might	may	MD
cord-012418-6ralcn8p	146	19	not	not	RB
cord-012418-6ralcn8p	146	20	yet	yet	RB
cord-012418-6ralcn8p	146	21	be	be	VB
cord-012418-6ralcn8p	146	22	fully	fully	RB
cord-012418-6ralcn8p	146	23	activated	activate	VBN
cord-012418-6ralcn8p	146	24	when	when	WRB
cord-012418-6ralcn8p	146	25	initiating	initiate	VBG
cord-012418-6ralcn8p	146	26	a	a	DT
cord-012418-6ralcn8p	146	27	first	first	JJ
cord-012418-6ralcn8p	146	28	wave	wave	NN
cord-012418-6ralcn8p	146	29	of	of	IN
cord-012418-6ralcn8p	146	30	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	146	31	expression	expression	NN
cord-012418-6ralcn8p	146	32	.	.	.
cord-012418-6ralcn8p	147	1	Instead	instead	RB
cord-012418-6ralcn8p	147	2	,	,	,
cord-012418-6ralcn8p	147	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	147	4	might	may	MD
cord-012418-6ralcn8p	147	5	acquire	acquire	VB
cord-012418-6ralcn8p	147	6	modifications	modification	NNS
cord-012418-6ralcn8p	147	7	and	and	CC
cord-012418-6ralcn8p	147	8	engage	engage	VB
cord-012418-6ralcn8p	147	9	in	in	IN
cord-012418-6ralcn8p	147	10	distinct	distinct	JJ
cord-012418-6ralcn8p	147	11	interactions	interaction	NNS
cord-012418-6ralcn8p	147	12	in	in	IN
cord-012418-6ralcn8p	147	13	different	different	JJ
cord-012418-6ralcn8p	147	14	waves	wave	NNS
cord-012418-6ralcn8p	147	15	of	of	IN
cord-012418-6ralcn8p	147	16	the	the	DT
cord-012418-6ralcn8p	147	17	type	type	NN
cord-012418-6ralcn8p	147	18	I	-PRON-	PRP
cord-012418-6ralcn8p	147	19	IFN	IFN	NNP
cord-012418-6ralcn8p	147	20	response	response	NN
cord-012418-6ralcn8p	147	21	until	until	IN
cord-012418-6ralcn8p	147	22	it	-PRON-	PRP
cord-012418-6ralcn8p	147	23	is	be	VBZ
cord-012418-6ralcn8p	147	24	fully	fully	RB
cord-012418-6ralcn8p	147	25	activated	activate	VBN
cord-012418-6ralcn8p	147	26	.	.	.
cord-012418-6ralcn8p	148	1	In	in	IN
cord-012418-6ralcn8p	148	2	line	line	NN
cord-012418-6ralcn8p	148	3	with	with	IN
cord-012418-6ralcn8p	148	4	this	this	DT
cord-012418-6ralcn8p	148	5	,	,	,
cord-012418-6ralcn8p	148	6	we	-PRON-	PRP
cord-012418-6ralcn8p	148	7	noticed	notice	VBD
cord-012418-6ralcn8p	148	8	several	several	JJ
cord-012418-6ralcn8p	148	9	reports	report	NNS
cord-012418-6ralcn8p	148	10	referring	refer	VBG
cord-012418-6ralcn8p	148	11	to	to	IN
cord-012418-6ralcn8p	148	12	"	"	``
cord-012418-6ralcn8p	148	13	full	full	JJ
cord-012418-6ralcn8p	148	14	"	"	''
cord-012418-6ralcn8p	148	15	activity	activity	NN
cord-012418-6ralcn8p	148	16	of	of	IN
cord-012418-6ralcn8p	148	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	148	18	in	in	IN
cord-012418-6ralcn8p	148	19	later	later	JJ
cord-012418-6ralcn8p	148	20	loops	loop	NNS
cord-012418-6ralcn8p	148	21	of	of	IN
cord-012418-6ralcn8p	148	22	the	the	DT
cord-012418-6ralcn8p	148	23	response	response	NN
cord-012418-6ralcn8p	148	24	,	,	,
cord-012418-6ralcn8p	148	25	for	for	IN
cord-012418-6ralcn8p	148	26	example	example	NN
cord-012418-6ralcn8p	148	27	enabled	enable	VBN
cord-012418-6ralcn8p	148	28	by	by	IN
cord-012418-6ralcn8p	148	29	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	148	30	at	at	IN
cord-012418-6ralcn8p	148	31	both	both	DT
cord-012418-6ralcn8p	148	32	clusters	cluster	NNS
cord-012418-6ralcn8p	148	33	of	of	IN
cord-012418-6ralcn8p	148	34	the	the	DT
cord-012418-6ralcn8p	148	35	AIE	AIE	NNP
cord-012418-6ralcn8p	148	36	or	or	CC
cord-012418-6ralcn8p	148	37	determined	determine	VBN
cord-012418-6ralcn8p	148	38	only	only	RB
cord-012418-6ralcn8p	148	39	in	in	IN
cord-012418-6ralcn8p	148	40	the	the	DT
cord-012418-6ralcn8p	148	41	presence	presence	NN
cord-012418-6ralcn8p	148	42	of	of	IN
cord-012418-6ralcn8p	148	43	IFNAR	IFNAR	NNP
cord-012418-6ralcn8p	148	44	signalling	signal	VBG
cord-012418-6ralcn8p	148	45	[	[	-LRB-
cord-012418-6ralcn8p	148	46	55	55	CD
cord-012418-6ralcn8p	148	47	,	,	,
cord-012418-6ralcn8p	148	48	65	65	CD
cord-012418-6ralcn8p	148	49	]	]	-RRB-
cord-012418-6ralcn8p	148	50	.	.	.
cord-012418-6ralcn8p	149	1	This	this	DT
cord-012418-6ralcn8p	149	2	aligns	align	VBZ
cord-012418-6ralcn8p	149	3	with	with	IN
cord-012418-6ralcn8p	149	4	the	the	DT
cord-012418-6ralcn8p	149	5	kinetics	kinetic	NNS
cord-012418-6ralcn8p	149	6	of	of	IN
cord-012418-6ralcn8p	149	7	the	the	DT
cord-012418-6ralcn8p	149	8	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	149	9	response	response	NN
cord-012418-6ralcn8p	149	10	we	-PRON-	PRP
cord-012418-6ralcn8p	149	11	will	will	MD
cord-012418-6ralcn8p	149	12	briefly	briefly	RB
cord-012418-6ralcn8p	149	13	revisit	revisit	VB
cord-012418-6ralcn8p	149	14	below	below	RB
cord-012418-6ralcn8p	149	15	(	(	-LRB-
cord-012418-6ralcn8p	149	16	see	see	VB
cord-012418-6ralcn8p	149	17	Section	Section	NNP
cord-012418-6ralcn8p	149	18	3.3	3.3	CD
cord-012418-6ralcn8p	149	19	)	)	-RRB-
cord-012418-6ralcn8p	149	20	,	,	,
cord-012418-6ralcn8p	149	21	wherein	wherein	WRB
cord-012418-6ralcn8p	149	22	only	only	RB
cord-012418-6ralcn8p	149	23	a	a	DT
cord-012418-6ralcn8p	149	24	part	part	NN
cord-012418-6ralcn8p	149	25	of	of	IN
cord-012418-6ralcn8p	149	26	the	the	DT
cord-012418-6ralcn8p	149	27	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	149	28	alleles	allele	NNS
cord-012418-6ralcn8p	149	29	are	be	VBP
cord-012418-6ralcn8p	149	30	engaged	engage	VBN
cord-012418-6ralcn8p	149	31	in	in	IN
cord-012418-6ralcn8p	149	32	the	the	DT
cord-012418-6ralcn8p	149	33	early	early	JJ
cord-012418-6ralcn8p	149	34	response	response	NN
cord-012418-6ralcn8p	149	35	.	.	.
cord-012418-6ralcn8p	150	1	Expression	expression	NN
cord-012418-6ralcn8p	150	2	of	of	IN
cord-012418-6ralcn8p	150	3	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	150	4	is	be	VBZ
cord-012418-6ralcn8p	150	5	probably	probably	RB
cord-012418-6ralcn8p	150	6	the	the	DT
cord-012418-6ralcn8p	150	7	best	well	RBS
cord-012418-6ralcn8p	150	8	studied	study	VBN
cord-012418-6ralcn8p	150	9	model	model	NN
cord-012418-6ralcn8p	150	10	of	of	IN
cord-012418-6ralcn8p	150	11	induced	induce	VBN
cord-012418-6ralcn8p	150	12	eukaryotic	eukaryotic	JJ
cord-012418-6ralcn8p	150	13	gene	gene	NN
cord-012418-6ralcn8p	150	14	regulation	regulation	NN
cord-012418-6ralcn8p	150	15	.	.	.
cord-012418-6ralcn8p	151	1	It	-PRON-	PRP
cord-012418-6ralcn8p	151	2	exemplifies	exemplify	VBZ
cord-012418-6ralcn8p	151	3	how	how	WRB
cord-012418-6ralcn8p	151	4	factors	factor	NNS
cord-012418-6ralcn8p	151	5	activated	activate	VBN
cord-012418-6ralcn8p	151	6	by	by	IN
cord-012418-6ralcn8p	151	7	specific	specific	JJ
cord-012418-6ralcn8p	151	8	signals	signal	NNS
cord-012418-6ralcn8p	151	9	cooperate	cooperate	VBP
cord-012418-6ralcn8p	151	10	to	to	TO
cord-012418-6ralcn8p	151	11	prompt	prompt	VB
cord-012418-6ralcn8p	151	12	a	a	DT
cord-012418-6ralcn8p	151	13	defined	define	VBN
cord-012418-6ralcn8p	151	14	expression	expression	NN
cord-012418-6ralcn8p	151	15	programme	programme	NN
cord-012418-6ralcn8p	151	16	,	,	,
cord-012418-6ralcn8p	151	17	as	as	IN
cord-012418-6ralcn8p	151	18	reviewed	review	VBN
cord-012418-6ralcn8p	151	19	before	before	IN
cord-012418-6ralcn8p	151	20	[	[	-LRB-
cord-012418-6ralcn8p	151	21	17	17	CD
cord-012418-6ralcn8p	151	22	,	,	,
cord-012418-6ralcn8p	151	23	[	[	-LRB-
cord-012418-6ralcn8p	151	24	66	66	CD
cord-012418-6ralcn8p	151	25	]	]	-RRB-
cord-012418-6ralcn8p	151	26	[	[	-LRB-
cord-012418-6ralcn8p	151	27	67	67	CD
cord-012418-6ralcn8p	151	28	]	]	-RRB-
cord-012418-6ralcn8p	151	29	[	[	-LRB-
cord-012418-6ralcn8p	151	30	68	68	CD
cord-012418-6ralcn8p	151	31	]	]	-RRB-
cord-012418-6ralcn8p	151	32	.	.	.
cord-012418-6ralcn8p	152	1	Upon	upon	IN
cord-012418-6ralcn8p	152	2	viral	viral	JJ
cord-012418-6ralcn8p	152	3	stimulation	stimulation	NN
cord-012418-6ralcn8p	152	4	,	,	,
cord-012418-6ralcn8p	152	5	a	a	DT
cord-012418-6ralcn8p	152	6	multicomponent	multicomponent	JJ
cord-012418-6ralcn8p	152	7	complex	complex	NN
cord-012418-6ralcn8p	152	8	of	of	IN
cord-012418-6ralcn8p	152	9	transcription	transcription	NN
cord-012418-6ralcn8p	152	10	factors	factor	NNS
cord-012418-6ralcn8p	152	11	,	,	,
cord-012418-6ralcn8p	152	12	coactivators	coactivator	NNS
cord-012418-6ralcn8p	152	13	and	and	CC
cord-012418-6ralcn8p	152	14	architectural	architectural	JJ
cord-012418-6ralcn8p	152	15	proteins	protein	NNS
cord-012418-6ralcn8p	152	16	forms	form	NNS
cord-012418-6ralcn8p	152	17	at	at	IN
cord-012418-6ralcn8p	152	18	the	the	DT
cord-012418-6ralcn8p	152	19	enhancer	enhancer	NN
cord-012418-6ralcn8p	152	20	sequence	sequence	NN
cord-012418-6ralcn8p	152	21	upstream	upstream	RB
cord-012418-6ralcn8p	152	22	of	of	IN
cord-012418-6ralcn8p	152	23	the	the	DT
cord-012418-6ralcn8p	152	24	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	152	25	gene	gene	NN
cord-012418-6ralcn8p	152	26	promoter	promoter	NN
cord-012418-6ralcn8p	152	27	.	.	.
cord-012418-6ralcn8p	153	1	This	this	DT
cord-012418-6ralcn8p	153	2	higher	high	JJR
cord-012418-6ralcn8p	153	3	-	-	HYPH
cord-012418-6ralcn8p	153	4	order	order	NN
cord-012418-6ralcn8p	153	5	nucleoprotein	nucleoprotein	NNP
cord-012418-6ralcn8p	153	6	complex	complex	NNP
cord-012418-6ralcn8p	153	7	,	,	,
cord-012418-6ralcn8p	153	8	termed	term	VBD
cord-012418-6ralcn8p	153	9	the	the	DT
cord-012418-6ralcn8p	153	10	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	153	11	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	153	12	,	,	,
cord-012418-6ralcn8p	153	13	works	work	VBZ
cord-012418-6ralcn8p	153	14	as	as	IN
cord-012418-6ralcn8p	153	15	a	a	DT
cord-012418-6ralcn8p	153	16	molecular	molecular	JJ
cord-012418-6ralcn8p	153	17	switch	switch	NN
cord-012418-6ralcn8p	153	18	that	that	WDT
cord-012418-6ralcn8p	153	19	turns	turn	VBZ
cord-012418-6ralcn8p	153	20	on	on	RP
cord-012418-6ralcn8p	153	21	upon	upon	IN
cord-012418-6ralcn8p	153	22	virus	virus	NN
cord-012418-6ralcn8p	153	23	-	-	HYPH
cord-012418-6ralcn8p	153	24	induced	induce	VBN
cord-012418-6ralcn8p	153	25	activation	activation	NN
cord-012418-6ralcn8p	153	26	of	of	IN
cord-012418-6ralcn8p	153	27	a	a	DT
cord-012418-6ralcn8p	153	28	specific	specific	JJ
cord-012418-6ralcn8p	153	29	set	set	NN
cord-012418-6ralcn8p	153	30	of	of	IN
cord-012418-6ralcn8p	153	31	transcription	transcription	NN
cord-012418-6ralcn8p	153	32	factors	factor	NNS
cord-012418-6ralcn8p	153	33	[	[	-LRB-
cord-012418-6ralcn8p	153	34	69	69	CD
cord-012418-6ralcn8p	153	35	,	,	,
cord-012418-6ralcn8p	153	36	70	70	CD
cord-012418-6ralcn8p	153	37	]	]	-RRB-
cord-012418-6ralcn8p	153	38	.	.	.
cord-012418-6ralcn8p	154	1	When	when	WRB
cord-012418-6ralcn8p	154	2	completed	complete	VBN
cord-012418-6ralcn8p	154	3	,	,	,
cord-012418-6ralcn8p	154	4	the	the	DT
cord-012418-6ralcn8p	154	5	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	154	6	in	in	IN
cord-012418-6ralcn8p	154	7	turn	turn	NN
cord-012418-6ralcn8p	154	8	recruits	recruit	VBZ
cord-012418-6ralcn8p	154	9	factors	factor	NNS
cord-012418-6ralcn8p	154	10	with	with	IN
cord-012418-6ralcn8p	154	11	chromatin	chromatin	NN
cord-012418-6ralcn8p	154	12	-	-	HYPH
cord-012418-6ralcn8p	154	13	modifying	modify	VBG
cord-012418-6ralcn8p	154	14	activities	activity	NNS
cord-012418-6ralcn8p	154	15	as	as	RB
cord-012418-6ralcn8p	154	16	well	well	RB
cord-012418-6ralcn8p	154	17	as	as	IN
cord-012418-6ralcn8p	154	18	basal	basal	NN
cord-012418-6ralcn8p	154	19	eukaryotic	eukaryotic	JJ
cord-012418-6ralcn8p	154	20	transcription	transcription	NN
cord-012418-6ralcn8p	154	21	factors	factor	NNS
cord-012418-6ralcn8p	154	22	to	to	IN
cord-012418-6ralcn8p	154	23	the	the	DT
cord-012418-6ralcn8p	154	24	nearby	nearby	JJ
cord-012418-6ralcn8p	154	25	transcription	transcription	NN
cord-012418-6ralcn8p	154	26	start	start	NN
cord-012418-6ralcn8p	154	27	site	site	NN
cord-012418-6ralcn8p	154	28	(	(	-LRB-
cord-012418-6ralcn8p	154	29	TSS	TSS	NNP
cord-012418-6ralcn8p	154	30	)	)	-RRB-
cord-012418-6ralcn8p	154	31	to	to	TO
cord-012418-6ralcn8p	154	32	initiate	initiate	VB
cord-012418-6ralcn8p	154	33	gene	gene	NN
cord-012418-6ralcn8p	154	34	expression	expression	NN
cord-012418-6ralcn8p	154	35	.	.	.
cord-012418-6ralcn8p	155	1	The	the	DT
cord-012418-6ralcn8p	155	2	assembly	assembly	NN
cord-012418-6ralcn8p	155	3	is	be	VBZ
cord-012418-6ralcn8p	155	4	regulated	regulate	VBN
cord-012418-6ralcn8p	155	5	at	at	IN
cord-012418-6ralcn8p	155	6	several	several	JJ
cord-012418-6ralcn8p	155	7	levels	level	NNS
cord-012418-6ralcn8p	155	8	and	and	CC
cord-012418-6ralcn8p	155	9	highly	highly	RB
cord-012418-6ralcn8p	155	10	specific	specific	JJ
cord-012418-6ralcn8p	155	11	due	due	IN
cord-012418-6ralcn8p	155	12	to	to	IN
cord-012418-6ralcn8p	155	13	an	an	DT
cord-012418-6ralcn8p	155	14	elaborate	elaborate	JJ
cord-012418-6ralcn8p	155	15	organisation	organisation	NN
cord-012418-6ralcn8p	155	16	of	of	IN
cord-012418-6ralcn8p	155	17	transcription	transcription	NN
cord-012418-6ralcn8p	155	18	factor	factor	NN
cord-012418-6ralcn8p	155	19	binding	bind	VBG
cord-012418-6ralcn8p	155	20	motifs	motif	NNS
cord-012418-6ralcn8p	155	21	,	,	,
cord-012418-6ralcn8p	155	22	the	the	DT
cord-012418-6ralcn8p	155	23	required	require	VBN
cord-012418-6ralcn8p	155	24	set	set	NN
cord-012418-6ralcn8p	155	25	of	of	IN
cord-012418-6ralcn8p	155	26	activated	activate	VBN
cord-012418-6ralcn8p	155	27	transcription	transcription	NN
cord-012418-6ralcn8p	155	28	factors	factor	NNS
cord-012418-6ralcn8p	155	29	and	and	CC
cord-012418-6ralcn8p	155	30	architectural	architectural	JJ
cord-012418-6ralcn8p	155	31	proteins	protein	NNS
cord-012418-6ralcn8p	155	32	and	and	CC
cord-012418-6ralcn8p	155	33	finely	finely	RB
cord-012418-6ralcn8p	155	34	coordinated	coordinate	VBN
cord-012418-6ralcn8p	155	35	interactions	interaction	NNS
cord-012418-6ralcn8p	155	36	of	of	IN
cord-012418-6ralcn8p	155	37	the	the	DT
cord-012418-6ralcn8p	155	38	individual	individual	JJ
cord-012418-6ralcn8p	155	39	participants	participant	NNS
cord-012418-6ralcn8p	155	40	as	as	RB
cord-012418-6ralcn8p	155	41	well	well	RB
cord-012418-6ralcn8p	155	42	as	as	IN
cord-012418-6ralcn8p	155	43	of	of	IN
cord-012418-6ralcn8p	155	44	the	the	DT
cord-012418-6ralcn8p	155	45	arising	arise	VBG
cord-012418-6ralcn8p	155	46	composite	composite	JJ
cord-012418-6ralcn8p	155	47	structures	structure	NNS
cord-012418-6ralcn8p	155	48	.	.	.
cord-012418-6ralcn8p	156	1	From	from	IN
cord-012418-6ralcn8p	156	2	just	just	RB
cord-012418-6ralcn8p	156	3	slightly	slightly	RB
cord-012418-6ralcn8p	156	4	upstream	upstream	RB
cord-012418-6ralcn8p	156	5	of	of	IN
cord-012418-6ralcn8p	156	6	the	the	DT
cord-012418-6ralcn8p	156	7	TSS	TSS	NNP
cord-012418-6ralcn8p	156	8	of	of	IN
cord-012418-6ralcn8p	156	9	the	the	DT
cord-012418-6ralcn8p	156	10	human	human	JJ
cord-012418-6ralcn8p	156	11	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	156	12	gene	gene	NN
cord-012418-6ralcn8p	156	13	,	,	,
cord-012418-6ralcn8p	156	14	a	a	DT
cord-012418-6ralcn8p	156	15	precisely	precisely	RB
cord-012418-6ralcn8p	156	16	arranged	arrange	VBN
cord-012418-6ralcn8p	156	17	sequence	sequence	NN
cord-012418-6ralcn8p	156	18	of	of	IN
cord-012418-6ralcn8p	156	19	cis	cis	NNP
cord-012418-6ralcn8p	156	20	-	-	HYPH
cord-012418-6ralcn8p	156	21	acting	act	VBG
cord-012418-6ralcn8p	156	22	DNA	DNA	NNP
cord-012418-6ralcn8p	156	23	constitutes	constitute	VBZ
cord-012418-6ralcn8p	156	24	the	the	DT
cord-012418-6ralcn8p	156	25	key	key	JJ
cord-012418-6ralcn8p	156	26	enhancer	enhancer	NN
cord-012418-6ralcn8p	156	27	element	element	NN
cord-012418-6ralcn8p	156	28	that	that	WDT
cord-012418-6ralcn8p	156	29	defines	define	VBZ
cord-012418-6ralcn8p	156	30	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	156	31	expression	expression	NN
cord-012418-6ralcn8p	156	32	.	.	.
cord-012418-6ralcn8p	157	1	The	the	DT
cord-012418-6ralcn8p	157	2	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	157	3	enhancer	enhancer	NN
cord-012418-6ralcn8p	157	4	itself	-PRON-	PRP
cord-012418-6ralcn8p	157	5	is	be	VBZ
cord-012418-6ralcn8p	157	6	accessible	accessible	JJ
cord-012418-6ralcn8p	158	1	yet	yet	CC
cord-012418-6ralcn8p	158	2	directly	directly	RB
cord-012418-6ralcn8p	158	3	flanked	flank	VBN
cord-012418-6ralcn8p	158	4	by	by	IN
cord-012418-6ralcn8p	158	5	two	two	CD
cord-012418-6ralcn8p	158	6	nucleosomes	nucleosome	NNS
cord-012418-6ralcn8p	158	7	,	,	,
cord-012418-6ralcn8p	158	8	one	one	CD
cord-012418-6ralcn8p	158	9	of	of	IN
cord-012418-6ralcn8p	158	10	them	-PRON-	PRP
cord-012418-6ralcn8p	158	11	covering	cover	VBG
cord-012418-6ralcn8p	158	12	the	the	DT
cord-012418-6ralcn8p	158	13	TSS	TSS	NNP
cord-012418-6ralcn8p	158	14	and	and	CC
cord-012418-6ralcn8p	158	15	a	a	DT
cord-012418-6ralcn8p	158	16	TATA	TATA	NNP
cord-012418-6ralcn8p	158	17	box	box	NN
cord-012418-6ralcn8p	158	18	[	[	-LRB-
cord-012418-6ralcn8p	158	19	71	71	CD
cord-012418-6ralcn8p	158	20	]	]	-RRB-
cord-012418-6ralcn8p	158	21	.	.	.
cord-012418-6ralcn8p	159	1	This	this	DT
cord-012418-6ralcn8p	159	2	setup	setup	NN
cord-012418-6ralcn8p	159	3	strategically	strategically	RB
cord-012418-6ralcn8p	159	4	restricts	restrict	VBZ
cord-012418-6ralcn8p	159	5	the	the	DT
cord-012418-6ralcn8p	159	6	access	access	NN
cord-012418-6ralcn8p	159	7	of	of	IN
cord-012418-6ralcn8p	159	8	the	the	DT
cord-012418-6ralcn8p	159	9	transcription	transcription	NN
cord-012418-6ralcn8p	159	10	machinery	machinery	NN
cord-012418-6ralcn8p	159	11	in	in	IN
cord-012418-6ralcn8p	159	12	latent	latent	JJ
cord-012418-6ralcn8p	159	13	conditions	condition	NNS
cord-012418-6ralcn8p	159	14	[	[	-LRB-
cord-012418-6ralcn8p	159	15	72	72	CD
cord-012418-6ralcn8p	159	16	,	,	,
cord-012418-6ralcn8p	159	17	73	73	CD
cord-012418-6ralcn8p	159	18	]	]	-RRB-
cord-012418-6ralcn8p	159	19	.	.	.
cord-012418-6ralcn8p	160	1	The	the	DT
cord-012418-6ralcn8p	160	2	enhancer	enhancer	NN
cord-012418-6ralcn8p	160	3	can	can	MD
cord-012418-6ralcn8p	160	4	be	be	VB
cord-012418-6ralcn8p	160	5	divided	divide	VBN
cord-012418-6ralcn8p	160	6	into	into	IN
cord-012418-6ralcn8p	160	7	four	four	CD
cord-012418-6ralcn8p	160	8	positive	positive	JJ
cord-012418-6ralcn8p	160	9	regulatory	regulatory	JJ
cord-012418-6ralcn8p	160	10	domains	domain	NNS
cord-012418-6ralcn8p	160	11	(	(	-LRB-
cord-012418-6ralcn8p	160	12	PRDs	prd	NNS
cord-012418-6ralcn8p	160	13	)	)	-RRB-
cord-012418-6ralcn8p	160	14	in	in	IN
cord-012418-6ralcn8p	160	15	the	the	DT
cord-012418-6ralcn8p	160	16	order	order	NN
cord-012418-6ralcn8p	160	17	IV	IV	NNP
cord-012418-6ralcn8p	160	18	-	-	HYPH
cord-012418-6ralcn8p	160	19	III	III	NNP
cord-012418-6ralcn8p	160	20	-	-	HYPH
cord-012418-6ralcn8p	160	21	I	I	NNP
cord-012418-6ralcn8p	160	22	-	-	HYPH
cord-012418-6ralcn8p	160	23	II	II	NNP
cord-012418-6ralcn8p	160	24	that	that	WDT
cord-012418-6ralcn8p	160	25	are	be	VBP
cord-012418-6ralcn8p	160	26	discussed	discuss	VBN
cord-012418-6ralcn8p	160	27	in	in	IN
cord-012418-6ralcn8p	160	28	detail	detail	NN
cord-012418-6ralcn8p	160	29	in	in	IN
cord-012418-6ralcn8p	160	30	[	[	-LRB-
cord-012418-6ralcn8p	160	31	68	68	CD
cord-012418-6ralcn8p	160	32	]	]	-RRB-
cord-012418-6ralcn8p	160	33	.	.	.
cord-012418-6ralcn8p	161	1	Of	of	IN
cord-012418-6ralcn8p	161	2	note	note	NN
cord-012418-6ralcn8p	161	3	,	,	,
cord-012418-6ralcn8p	161	4	however	however	RB
cord-012418-6ralcn8p	161	5	,	,	,
cord-012418-6ralcn8p	161	6	is	be	VBZ
cord-012418-6ralcn8p	161	7	the	the	DT
cord-012418-6ralcn8p	161	8	overall	overall	JJ
cord-012418-6ralcn8p	161	9	architecture	architecture	NN
cord-012418-6ralcn8p	161	10	that	that	WDT
cord-012418-6ralcn8p	161	11	is	be	VBZ
cord-012418-6ralcn8p	161	12	essential	essential	JJ
cord-012418-6ralcn8p	161	13	for	for	IN
cord-012418-6ralcn8p	161	14	the	the	DT
cord-012418-6ralcn8p	161	15	precise	precise	JJ
cord-012418-6ralcn8p	161	16	recognition	recognition	NN
cord-012418-6ralcn8p	161	17	and	and	CC
cord-012418-6ralcn8p	161	18	following	follow	VBG
cord-012418-6ralcn8p	161	19	interplay	interplay	NN
cord-012418-6ralcn8p	161	20	of	of	IN
cord-012418-6ralcn8p	161	21	the	the	DT
cord-012418-6ralcn8p	161	22	array	array	NN
cord-012418-6ralcn8p	161	23	of	of	IN
cord-012418-6ralcn8p	161	24	core	core	NN
cord-012418-6ralcn8p	161	25	transcription	transcription	NN
cord-012418-6ralcn8p	161	26	factors	factor	NNS
cord-012418-6ralcn8p	161	27	[	[	-LRB-
cord-012418-6ralcn8p	161	28	74	74	CD
cord-012418-6ralcn8p	161	29	]	]	-RRB-
cord-012418-6ralcn8p	161	30	.	.	.
cord-012418-6ralcn8p	162	1	The	the	DT
cord-012418-6ralcn8p	162	2	PRD	PRD	NNP
cord-012418-6ralcn8p	162	3	farthest	farthest	RBS
cord-012418-6ralcn8p	162	4	away	away	RB
cord-012418-6ralcn8p	162	5	from	from	IN
cord-012418-6ralcn8p	162	6	the	the	DT
cord-012418-6ralcn8p	162	7	promoter	promoter	NN
cord-012418-6ralcn8p	162	8	,	,	,
cord-012418-6ralcn8p	162	9	PRDIV	PRDIV	NNP
cord-012418-6ralcn8p	162	10	,	,	,
cord-012418-6ralcn8p	162	11	features	feature	VBZ
cord-012418-6ralcn8p	162	12	motifs	motif	NNS
cord-012418-6ralcn8p	162	13	for	for	IN
cord-012418-6ralcn8p	162	14	binding	bind	VBG
cord-012418-6ralcn8p	162	15	an	an	DT
cord-012418-6ralcn8p	162	16	AP-1	AP-1	NNP
cord-012418-6ralcn8p	162	17	heterodimer	heterodimer	NN
cord-012418-6ralcn8p	162	18	formed	form	VBN
cord-012418-6ralcn8p	162	19	by	by	IN
cord-012418-6ralcn8p	162	20	activating	activate	VBG
cord-012418-6ralcn8p	162	21	transcription	transcription	NN
cord-012418-6ralcn8p	162	22	factor	factor	NN
cord-012418-6ralcn8p	162	23	2	2	CD
cord-012418-6ralcn8p	162	24	(	(	-LRB-
cord-012418-6ralcn8p	162	25	ATF2	ATF2	NNP
cord-012418-6ralcn8p	162	26	)	)	-RRB-
cord-012418-6ralcn8p	162	27	and	and	CC
cord-012418-6ralcn8p	162	28	c	c	LS
cord-012418-6ralcn8p	162	29	-	-	:
cord-012418-6ralcn8p	162	30	Jun	Jun	NNP
cord-012418-6ralcn8p	162	31	of	of	IN
cord-012418-6ralcn8p	162	32	the	the	DT
cord-012418-6ralcn8p	162	33	basic	basic	JJ
cord-012418-6ralcn8p	162	34	-	-	HYPH
cord-012418-6ralcn8p	162	35	region	region	NN
cord-012418-6ralcn8p	162	36	leucine	leucine	NN
cord-012418-6ralcn8p	162	37	zipper	zipper	NN
cord-012418-6ralcn8p	162	38	(	(	-LRB-
cord-012418-6ralcn8p	162	39	bZIP	bZIP	VBG
cord-012418-6ralcn8p	162	40	)	)	-RRB-
cord-012418-6ralcn8p	162	41	family	family	NN
cord-012418-6ralcn8p	162	42	[	[	-LRB-
cord-012418-6ralcn8p	162	43	66	66	CD
cord-012418-6ralcn8p	162	44	,	,	,
cord-012418-6ralcn8p	162	45	75	75	CD
cord-012418-6ralcn8p	162	46	]	]	-RRB-
cord-012418-6ralcn8p	162	47	.	.	.
cord-012418-6ralcn8p	163	1	Binding	bind	VBG
cord-012418-6ralcn8p	163	2	of	of	IN
cord-012418-6ralcn8p	163	3	the	the	DT
cord-012418-6ralcn8p	163	4	heterodimer	heterodimer	NN
cord-012418-6ralcn8p	163	5	over	over	IN
cord-012418-6ralcn8p	163	6	homodimers	homodimer	NNS
cord-012418-6ralcn8p	163	7	is	be	VBZ
cord-012418-6ralcn8p	163	8	favoured	favour	VBN
cord-012418-6ralcn8p	163	9	by	by	IN
cord-012418-6ralcn8p	163	10	the	the	DT
cord-012418-6ralcn8p	163	11	intrinsic	intrinsic	JJ
cord-012418-6ralcn8p	163	12	architecture	architecture	NN
cord-012418-6ralcn8p	163	13	of	of	IN
cord-012418-6ralcn8p	163	14	the	the	DT
cord-012418-6ralcn8p	163	15	enhancer	enhancer	NN
cord-012418-6ralcn8p	163	16	and	and	CC
cord-012418-6ralcn8p	163	17	important	important	JJ
cord-012418-6ralcn8p	163	18	for	for	IN
cord-012418-6ralcn8p	163	19	subsequent	subsequent	JJ
cord-012418-6ralcn8p	163	20	interactions	interaction	NNS
cord-012418-6ralcn8p	163	21	[	[	-LRB-
cord-012418-6ralcn8p	163	22	76	76	CD
cord-012418-6ralcn8p	163	23	]	]	-RRB-
cord-012418-6ralcn8p	163	24	.	.	.
cord-012418-6ralcn8p	164	1	The	the	DT
cord-012418-6ralcn8p	164	2	last	last	JJ
cord-012418-6ralcn8p	164	3	PRD	prd	NN
cord-012418-6ralcn8p	164	4	in	in	IN
cord-012418-6ralcn8p	164	5	the	the	DT
cord-012418-6ralcn8p	164	6	sequence	sequence	NN
cord-012418-6ralcn8p	164	7	of	of	IN
cord-012418-6ralcn8p	164	8	the	the	DT
cord-012418-6ralcn8p	164	9	enhancer	enhancer	NN
cord-012418-6ralcn8p	164	10	,	,	,
cord-012418-6ralcn8p	164	11	PRDII	PRDII	NNP
cord-012418-6ralcn8p	164	12	,	,	,
cord-012418-6ralcn8p	164	13	is	be	VBZ
cord-012418-6ralcn8p	164	14	recognised	recognise	VBN
cord-012418-6ralcn8p	164	15	by	by	IN
cord-012418-6ralcn8p	164	16	a	a	DT
cord-012418-6ralcn8p	164	17	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	164	18	or	or	CC
cord-012418-6ralcn8p	164	19	p50-p50	p50-p50	NNP
cord-012418-6ralcn8p	164	20	NF	nf	NN
cord-012418-6ralcn8p	164	21	-	-	HYPH
cord-012418-6ralcn8p	164	22	κB	κb	CD
cord-012418-6ralcn8p	164	23	dimer	dimer	NN
cord-012418-6ralcn8p	164	24	[	[	-LRB-
cord-012418-6ralcn8p	164	25	77	77	CD
cord-012418-6ralcn8p	164	26	]	]	-RRB-
cord-012418-6ralcn8p	165	1	[	[	-LRB-
cord-012418-6ralcn8p	165	2	78	78	CD
cord-012418-6ralcn8p	165	3	]	]	-RRB-
cord-012418-6ralcn8p	165	4	[	[	-LRB-
cord-012418-6ralcn8p	165	5	79	79	CD
cord-012418-6ralcn8p	165	6	]	]	-RRB-
cord-012418-6ralcn8p	165	7	.	.	.
cord-012418-6ralcn8p	166	1	PRDIII	PRDIII	NNP
cord-012418-6ralcn8p	166	2	and	and	CC
cord-012418-6ralcn8p	166	3	PRDI	PRDI	NNP
cord-012418-6ralcn8p	166	4	in	in	IN
cord-012418-6ralcn8p	166	5	the	the	DT
cord-012418-6ralcn8p	166	6	middle	middle	JJ
cord-012418-6ralcn8p	166	7	section	section	NN
cord-012418-6ralcn8p	166	8	feature	feature	NN
cord-012418-6ralcn8p	166	9	in	in	IN
cord-012418-6ralcn8p	166	10	total	total	JJ
cord-012418-6ralcn8p	166	11	four	four	CD
cord-012418-6ralcn8p	166	12	overlapping	overlap	VBG
cord-012418-6ralcn8p	166	13	IRF	IRF	NNP
cord-012418-6ralcn8p	166	14	-	-	HYPH
cord-012418-6ralcn8p	166	15	binding	bind	VBG
cord-012418-6ralcn8p	166	16	elements	element	NNS
cord-012418-6ralcn8p	166	17	(	(	-LRB-
cord-012418-6ralcn8p	166	18	IRF	IRF	NNP
cord-012418-6ralcn8p	166	19	-	-	HYPH
cord-012418-6ralcn8p	166	20	Es	Es	NNP
cord-012418-6ralcn8p	166	21	)	)	-RRB-
cord-012418-6ralcn8p	166	22	of	of	IN
cord-012418-6ralcn8p	166	23	the	the	DT
cord-012418-6ralcn8p	166	24	consensus	consensus	NN
cord-012418-6ralcn8p	166	25	sequence	sequence	NN
cord-012418-6ralcn8p	166	26	5	5	CD
cord-012418-6ralcn8p	166	27	-AANNGAAA-3	-AANNGAAA-3	NNS
cord-012418-6ralcn8p	166	28	that	that	WDT
cord-012418-6ralcn8p	166	29	form	form	NN
cord-012418-6ralcn8p	166	30	two	two	CD
cord-012418-6ralcn8p	166	31	composite	composite	JJ
cord-012418-6ralcn8p	166	32	binding	binding	NN
cord-012418-6ralcn8p	166	33	sites	site	NNS
cord-012418-6ralcn8p	166	34	enabling	enable	VBG
cord-012418-6ralcn8p	166	35	binding	bind	VBG
cord-012418-6ralcn8p	166	36	of	of	IN
cord-012418-6ralcn8p	166	37	two	two	CD
cord-012418-6ralcn8p	166	38	IRF	IRF	NNP
cord-012418-6ralcn8p	166	39	dimers	dimer	NNS
cord-012418-6ralcn8p	166	40	[	[	-LRB-
cord-012418-6ralcn8p	166	41	34	34	CD
cord-012418-6ralcn8p	166	42	,	,	,
cord-012418-6ralcn8p	166	43	36	36	CD
cord-012418-6ralcn8p	166	44	,	,	,
cord-012418-6ralcn8p	166	45	80	80	CD
cord-012418-6ralcn8p	166	46	,	,	,
cord-012418-6ralcn8p	166	47	81	81	CD
cord-012418-6ralcn8p	166	48	]	]	-RRB-
cord-012418-6ralcn8p	166	49	.	.	.
cord-012418-6ralcn8p	167	1	This	this	DT
cord-012418-6ralcn8p	167	2	region	region	NN
cord-012418-6ralcn8p	167	3	was	be	VBD
cord-012418-6ralcn8p	167	4	also	also	RB
cord-012418-6ralcn8p	167	5	termed	term	VBN
cord-012418-6ralcn8p	167	6	P31	P31	NNP
cord-012418-6ralcn8p	167	7	because	because	IN
cord-012418-6ralcn8p	167	8	these	these	DT
cord-012418-6ralcn8p	167	9	two	two	CD
cord-012418-6ralcn8p	167	10	PRDs	prd	NNS
cord-012418-6ralcn8p	167	11	act	act	VBP
cord-012418-6ralcn8p	167	12	as	as	IN
cord-012418-6ralcn8p	167	13	a	a	DT
cord-012418-6ralcn8p	167	14	functional	functional	JJ
cord-012418-6ralcn8p	167	15	unit	unit	NN
cord-012418-6ralcn8p	167	16	,	,	,
cord-012418-6ralcn8p	167	17	an	an	DT
cord-012418-6ralcn8p	167	18	enhanson	enhanson	NN
cord-012418-6ralcn8p	167	19	[	[	-LRB-
cord-012418-6ralcn8p	167	20	38	38	CD
cord-012418-6ralcn8p	167	21	]	]	-RRB-
cord-012418-6ralcn8p	167	22	.	.	.
cord-012418-6ralcn8p	168	1	Recent	recent	JJ
cord-012418-6ralcn8p	168	2	in	in	IN
cord-012418-6ralcn8p	168	3	-	-	HYPH
cord-012418-6ralcn8p	168	4	depth	depth	NN
cord-012418-6ralcn8p	168	5	analysis	analysis	NN
cord-012418-6ralcn8p	168	6	of	of	IN
cord-012418-6ralcn8p	168	7	the	the	DT
cord-012418-6ralcn8p	168	8	binding	binding	JJ
cord-012418-6ralcn8p	168	9	requirements	requirement	NNS
cord-012418-6ralcn8p	168	10	of	of	IN
cord-012418-6ralcn8p	168	11	different	different	JJ
cord-012418-6ralcn8p	168	12	IRF	IRF	NNP
cord-012418-6ralcn8p	168	13	members	member	NNS
cord-012418-6ralcn8p	168	14	suggests	suggest	VBZ
cord-012418-6ralcn8p	168	15	that	that	IN
cord-012418-6ralcn8p	168	16	,	,	,
cord-012418-6ralcn8p	168	17	in	in	IN
cord-012418-6ralcn8p	168	18	addition	addition	NN
cord-012418-6ralcn8p	168	19	to	to	IN
cord-012418-6ralcn8p	168	20	a	a	DT
cord-012418-6ralcn8p	168	21	slight	slight	JJ
cord-012418-6ralcn8p	168	22	variation	variation	NN
cord-012418-6ralcn8p	168	23	of	of	IN
cord-012418-6ralcn8p	168	24	the	the	DT
cord-012418-6ralcn8p	168	25	core	core	NN
cord-012418-6ralcn8p	168	26	GAAA	GAAA	NNP
cord-012418-6ralcn8p	168	27	recognition	recognition	NN
cord-012418-6ralcn8p	168	28	motif	motif	NN
cord-012418-6ralcn8p	168	29	,	,	,
cord-012418-6ralcn8p	168	30	the	the	DT
cord-012418-6ralcn8p	168	31	flanking	flank	VBG
cord-012418-6ralcn8p	168	32	regions	region	NNS
cord-012418-6ralcn8p	168	33	along	along	IN
cord-012418-6ralcn8p	168	34	with	with	IN
cord-012418-6ralcn8p	168	35	the	the	DT
cord-012418-6ralcn8p	168	36	spacing	spacing	NN
cord-012418-6ralcn8p	168	37	in	in	RP
cord-012418-6ralcn8p	168	38	between	between	IN
cord-012418-6ralcn8p	168	39	the	the	DT
cord-012418-6ralcn8p	168	40	IRF	IRF	NNP
cord-012418-6ralcn8p	168	41	-	-	HYPH
cord-012418-6ralcn8p	168	42	Es	Es	NNP
cord-012418-6ralcn8p	168	43	contribute	contribute	VB
cord-012418-6ralcn8p	168	44	to	to	IN
cord-012418-6ralcn8p	168	45	specific	specific	JJ
cord-012418-6ralcn8p	168	46	binding	binding	NN
cord-012418-6ralcn8p	168	47	of	of	IN
cord-012418-6ralcn8p	168	48	distinct	distinct	JJ
cord-012418-6ralcn8p	168	49	IRF	IRF	NNP
cord-012418-6ralcn8p	168	50	family	family	NN
cord-012418-6ralcn8p	168	51	members	member	NNS
cord-012418-6ralcn8p	168	52	,	,	,
cord-012418-6ralcn8p	168	53	here	here	RB
cord-012418-6ralcn8p	168	54	favouring	favour	VBG
cord-012418-6ralcn8p	168	55	recruitment	recruitment	NN
cord-012418-6ralcn8p	168	56	of	of	IN
cord-012418-6ralcn8p	168	57	IRF3	IRF3	NNP
cord-012418-6ralcn8p	168	58	and	and	CC
cord-012418-6ralcn8p	168	59	IRF7	IRF7	NNP
cord-012418-6ralcn8p	168	60	[	[	-LRB-
cord-012418-6ralcn8p	168	61	81	81	CD
cord-012418-6ralcn8p	168	62	,	,	,
cord-012418-6ralcn8p	168	63	82	82	CD
cord-012418-6ralcn8p	168	64	]	]	-RRB-
cord-012418-6ralcn8p	168	65	.	.	.
cord-012418-6ralcn8p	169	1	The	the	DT
cord-012418-6ralcn8p	169	2	nucleotide	nucleotide	JJ
cord-012418-6ralcn8p	169	3	sequence	sequence	NN
cord-012418-6ralcn8p	169	4	of	of	IN
cord-012418-6ralcn8p	169	5	the	the	DT
cord-012418-6ralcn8p	169	6	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	169	7	enhancer	enhancer	NN
cord-012418-6ralcn8p	169	8	causes	cause	VBZ
cord-012418-6ralcn8p	169	9	a	a	DT
cord-012418-6ralcn8p	169	10	bent	bent	JJ
cord-012418-6ralcn8p	169	11	conformation	conformation	NN
cord-012418-6ralcn8p	169	12	of	of	IN
cord-012418-6ralcn8p	169	13	the	the	DT
cord-012418-6ralcn8p	169	14	DNA	dna	NN
cord-012418-6ralcn8p	169	15	helix	helix	NN
cord-012418-6ralcn8p	169	16	in	in	IN
cord-012418-6ralcn8p	169	17	inactive	inactive	JJ
cord-012418-6ralcn8p	169	18	conditions	condition	NNS
cord-012418-6ralcn8p	169	19	and	and	CC
cord-012418-6ralcn8p	169	20	in	in	IN
cord-012418-6ralcn8p	169	21	this	this	DT
cord-012418-6ralcn8p	169	22	way	way	NN
cord-012418-6ralcn8p	169	23	drives	drive	VBZ
cord-012418-6ralcn8p	169	24	cooperative	cooperative	JJ
cord-012418-6ralcn8p	169	25	binding	binding	NN
cord-012418-6ralcn8p	169	26	of	of	IN
cord-012418-6ralcn8p	169	27	the	the	DT
cord-012418-6ralcn8p	169	28	transcription	transcription	NN
cord-012418-6ralcn8p	169	29	factor	factor	NN
cord-012418-6ralcn8p	170	1	heterodimers	heterodimer	NNS
cord-012418-6ralcn8p	170	2	upon	upon	IN
cord-012418-6ralcn8p	170	3	stimulation	stimulation	NN
cord-012418-6ralcn8p	170	4	[	[	-LRB-
cord-012418-6ralcn8p	170	5	68	68	CD
cord-012418-6ralcn8p	170	6	]	]	-RRB-
cord-012418-6ralcn8p	170	7	.	.	.
cord-012418-6ralcn8p	171	1	After	after	IN
cord-012418-6ralcn8p	171	2	stimulus	stimulus	NN
cord-012418-6ralcn8p	171	3	-	-	HYPH
cord-012418-6ralcn8p	171	4	induced	induce	VBN
cord-012418-6ralcn8p	171	5	activation	activation	NN
cord-012418-6ralcn8p	171	6	,	,	,
cord-012418-6ralcn8p	171	7	the	the	DT
cord-012418-6ralcn8p	171	8	transcription	transcription	NN
cord-012418-6ralcn8p	171	9	factors	factor	NNS
cord-012418-6ralcn8p	171	10	translocate	translocate	VBP
cord-012418-6ralcn8p	171	11	into	into	IN
cord-012418-6ralcn8p	171	12	the	the	DT
cord-012418-6ralcn8p	171	13	nucleus	nucleus	NN
cord-012418-6ralcn8p	171	14	.	.	.
cord-012418-6ralcn8p	172	1	First	first	RB
cord-012418-6ralcn8p	172	2	,	,	,
cord-012418-6ralcn8p	172	3	the	the	DT
cord-012418-6ralcn8p	172	4	NF	nf	NN
cord-012418-6ralcn8p	172	5	-	-	HYPH
cord-012418-6ralcn8p	172	6	κB	κb	CD
cord-012418-6ralcn8p	172	7	dimer	dimer	NN
cord-012418-6ralcn8p	172	8	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	172	9	is	be	VBZ
cord-012418-6ralcn8p	172	10	recruited	recruit	VBN
cord-012418-6ralcn8p	172	11	and	and	CC
cord-012418-6ralcn8p	172	12	nucleates	nucleates	NNP
cord-012418-6ralcn8p	172	13	assembly	assembly	NNP
cord-012418-6ralcn8p	172	14	[	[	-LRB-
cord-012418-6ralcn8p	172	15	71	71	CD
cord-012418-6ralcn8p	172	16	]	]	-RRB-
cord-012418-6ralcn8p	172	17	.	.	.
cord-012418-6ralcn8p	173	1	Association	Association	NNP
cord-012418-6ralcn8p	173	2	of	of	IN
cord-012418-6ralcn8p	173	3	NF	NF	NNP
cord-012418-6ralcn8p	173	4	-	-	HYPH
cord-012418-6ralcn8p	173	5	κB	κB	NNP
cord-012418-6ralcn8p	173	6	is	be	VBZ
cord-012418-6ralcn8p	173	7	the	the	DT
cord-012418-6ralcn8p	173	8	most	most	RBS
cord-012418-6ralcn8p	173	9	limiting	limiting	JJ
cord-012418-6ralcn8p	173	10	factor	factor	NN
cord-012418-6ralcn8p	173	11	of	of	IN
cord-012418-6ralcn8p	173	12	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	173	13	assembly	assembly	NN
cord-012418-6ralcn8p	173	14	,	,	,
cord-012418-6ralcn8p	173	15	and	and	CC
cord-012418-6ralcn8p	173	16	to	to	TO
cord-012418-6ralcn8p	173	17	optimise	optimise	VB
cord-012418-6ralcn8p	173	18	recruitment	recruitment	NN
cord-012418-6ralcn8p	173	19	,	,	,
cord-012418-6ralcn8p	173	20	it	-PRON-	PRP
cord-012418-6ralcn8p	173	21	is	be	VBZ
cord-012418-6ralcn8p	173	22	initially	initially	RB
cord-012418-6ralcn8p	173	23	targeted	target	VBN
cord-012418-6ralcn8p	173	24	to	to	IN
cord-012418-6ralcn8p	173	25	three	three	CD
cord-012418-6ralcn8p	173	26	loci	locus	NNS
cord-012418-6ralcn8p	173	27	at	at	IN
cord-012418-6ralcn8p	173	28	distinct	distinct	JJ
cord-012418-6ralcn8p	173	29	chromatin	chromatin	NN
cord-012418-6ralcn8p	173	30	regions	region	NNS
cord-012418-6ralcn8p	173	31	via	via	IN
cord-012418-6ralcn8p	173	32	Alu	Alu	NNP
cord-012418-6ralcn8p	173	33	elements	element	NNS
cord-012418-6ralcn8p	173	34	,	,	,
cord-012418-6ralcn8p	173	35	also	also	RB
cord-012418-6ralcn8p	173	36	termed	term	VBN
cord-012418-6ralcn8p	173	37	NF	nf	NN
cord-012418-6ralcn8p	173	38	-	-	HYPH
cord-012418-6ralcn8p	173	39	κB	κb	CD
cord-012418-6ralcn8p	173	40	reception	reception	NN
cord-012418-6ralcn8p	173	41	centres	centre	NNS
cord-012418-6ralcn8p	173	42	(	(	-LRB-
cord-012418-6ralcn8p	173	43	NRCs	NRCs	NNP
cord-012418-6ralcn8p	173	44	)	)	-RRB-
cord-012418-6ralcn8p	173	45	[	[	-LRB-
cord-012418-6ralcn8p	173	46	71	71	CD
cord-012418-6ralcn8p	173	47	,	,	,
cord-012418-6ralcn8p	173	48	83	83	CD
cord-012418-6ralcn8p	173	49	,	,	,
cord-012418-6ralcn8p	173	50	84	84	CD
cord-012418-6ralcn8p	173	51	]	]	-RRB-
cord-012418-6ralcn8p	173	52	.	.	.
cord-012418-6ralcn8p	174	1	The	the	DT
cord-012418-6ralcn8p	174	2	transcription	transcription	NN
cord-012418-6ralcn8p	174	3	factor	factor	NN
cord-012418-6ralcn8p	175	1	ThPOK	ThPOK	NNP
cord-012418-6ralcn8p	175	2	(	(	-LRB-
cord-012418-6ralcn8p	175	3	T	t	NN
cord-012418-6ralcn8p	175	4	-	-	HYPH
cord-012418-6ralcn8p	175	5	helper	helper	NN
cord-012418-6ralcn8p	175	6	-	-	HYPH
cord-012418-6ralcn8p	175	7	inducing	induce	VBG
cord-012418-6ralcn8p	175	8	POZ	POZ	NNP
cord-012418-6ralcn8p	175	9	/	/	SYM
cord-012418-6ralcn8p	175	10	Krüppel	Krüppel	NNP
cord-012418-6ralcn8p	175	11	-	-	HYPH
cord-012418-6ralcn8p	175	12	like	like	JJ
cord-012418-6ralcn8p	175	13	factor	factor	NN
cord-012418-6ralcn8p	175	14	,	,	,
cord-012418-6ralcn8p	175	15	also	also	RB
cord-012418-6ralcn8p	175	16	ZBTB7B	ZBTB7B	NNP
cord-012418-6ralcn8p	175	17	)	)	-RRB-
cord-012418-6ralcn8p	175	18	binds	bind	VBZ
cord-012418-6ralcn8p	175	19	cooperatively	cooperatively	RB
cord-012418-6ralcn8p	175	20	with	with	IN
cord-012418-6ralcn8p	175	21	NF	nf	NN
cord-012418-6ralcn8p	175	22	-	-	HYPH
cord-012418-6ralcn8p	175	23	κB	κB	NNP
cord-012418-6ralcn8p	175	24	to	to	IN
cord-012418-6ralcn8p	175	25	these	these	DT
cord-012418-6ralcn8p	175	26	regions	region	NNS
cord-012418-6ralcn8p	175	27	,	,	,
cord-012418-6ralcn8p	175	28	and	and	CC
cord-012418-6ralcn8p	175	29	oligomerisation	oligomerisation	NN
cord-012418-6ralcn8p	175	30	of	of	IN
cord-012418-6ralcn8p	175	31	ThPOK	ThPOK	NNP
cord-012418-6ralcn8p	175	32	mediates	mediate	VBZ
cord-012418-6ralcn8p	175	33	interchromosomal	interchromosomal	JJ
cord-012418-6ralcn8p	175	34	interactions	interaction	NNS
cord-012418-6ralcn8p	175	35	of	of	IN
cord-012418-6ralcn8p	175	36	the	the	DT
cord-012418-6ralcn8p	175	37	NRCs	nrc	NNS
cord-012418-6ralcn8p	175	38	with	with	IN
cord-012418-6ralcn8p	175	39	the	the	DT
cord-012418-6ralcn8p	175	40	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	175	41	enhancer	enhancer	NN
cord-012418-6ralcn8p	175	42	to	to	TO
cord-012418-6ralcn8p	175	43	deliver	deliver	VB
cord-012418-6ralcn8p	175	44	NF	NF	NNP
cord-012418-6ralcn8p	175	45	-	-	HYPH
cord-012418-6ralcn8p	175	46	κB	κB	NNP
cord-012418-6ralcn8p	176	1	[	[	-LRB-
cord-012418-6ralcn8p	176	2	83	83	CD
cord-012418-6ralcn8p	176	3	,	,	,
cord-012418-6ralcn8p	176	4	84	84	CD
cord-012418-6ralcn8p	176	5	]	]	-RRB-
cord-012418-6ralcn8p	176	6	.	.	.
cord-012418-6ralcn8p	177	1	Alongside	alongside	IN
cord-012418-6ralcn8p	177	2	NF	NF	NNP
cord-012418-6ralcn8p	177	3	-	-	HYPH
cord-012418-6ralcn8p	177	4	κB	κB	NNP
cord-012418-6ralcn8p	177	5	,	,	,
cord-012418-6ralcn8p	177	6	the	the	DT
cord-012418-6ralcn8p	177	7	architectural	architectural	JJ
cord-012418-6ralcn8p	177	8	DNA	dna	NN
cord-012418-6ralcn8p	177	9	-	-	HYPH
cord-012418-6ralcn8p	177	10	binding	bind	VBG
cord-012418-6ralcn8p	177	11	high	high	JJ
cord-012418-6ralcn8p	177	12	mobility	mobility	NN
cord-012418-6ralcn8p	177	13	group	group	NN
cord-012418-6ralcn8p	177	14	protein	protein	NN
cord-012418-6ralcn8p	177	15	I(Y	I(Y	NNP
cord-012418-6ralcn8p	177	16	)	)	-RRB-
cord-012418-6ralcn8p	178	1	(	(	-LRB-
cord-012418-6ralcn8p	178	2	HMG	HMG	NNP
cord-012418-6ralcn8p	178	3	I(Y	I(Y	NNP
cord-012418-6ralcn8p	178	4	)	)	-RRB-
cord-012418-6ralcn8p	178	5	,	,	,
cord-012418-6ralcn8p	178	6	also	also	RB
cord-012418-6ralcn8p	178	7	HMGA1	HMGA1	NNP
cord-012418-6ralcn8p	178	8	)	)	-RRB-
cord-012418-6ralcn8p	178	9	binds	bind	VBZ
cord-012418-6ralcn8p	178	10	at	at	IN
cord-012418-6ralcn8p	178	11	two	two	CD
cord-012418-6ralcn8p	178	12	sites	site	NNS
cord-012418-6ralcn8p	178	13	to	to	IN
cord-012418-6ralcn8p	178	14	the	the	DT
cord-012418-6ralcn8p	178	15	minor	minor	JJ
cord-012418-6ralcn8p	178	16	groove	groove	NN
cord-012418-6ralcn8p	178	17	in	in	IN
cord-012418-6ralcn8p	178	18	PRDII	PRDII	NNP
cord-012418-6ralcn8p	178	19	and	and	CC
cord-012418-6ralcn8p	178	20	straightens	straighten	VBZ
cord-012418-6ralcn8p	178	21	the	the	DT
cord-012418-6ralcn8p	178	22	DNA	dna	NN
cord-012418-6ralcn8p	178	23	conformation	conformation	NN
cord-012418-6ralcn8p	178	24	,	,	,
cord-012418-6ralcn8p	178	25	thereby	thereby	RB
cord-012418-6ralcn8p	178	26	supporting	support	VBG
cord-012418-6ralcn8p	178	27	interaction	interaction	NN
cord-012418-6ralcn8p	178	28	of	of	IN
cord-012418-6ralcn8p	178	29	NF	nf	NN
cord-012418-6ralcn8p	179	1	-κB	-κB	.
cord-012418-6ralcn8p	180	1	[	[	-LRB-
cord-012418-6ralcn8p	180	2	69	69	CD
cord-012418-6ralcn8p	180	3	,	,	,
cord-012418-6ralcn8p	180	4	[	[	-LRB-
cord-012418-6ralcn8p	180	5	85	85	CD
cord-012418-6ralcn8p	180	6	]	]	-RRB-
cord-012418-6ralcn8p	180	7	[	[	-LRB-
cord-012418-6ralcn8p	180	8	86	86	CD
cord-012418-6ralcn8p	180	9	]	]	-RRB-
cord-012418-6ralcn8p	180	10	[	[	-LRB-
cord-012418-6ralcn8p	180	11	87	87	CD
cord-012418-6ralcn8p	180	12	]	]	-RRB-
cord-012418-6ralcn8p	180	13	[	[	-LRB-
cord-012418-6ralcn8p	180	14	88	88	CD
cord-012418-6ralcn8p	180	15	]	]	-RRB-
cord-012418-6ralcn8p	180	16	.	.	.
cord-012418-6ralcn8p	181	1	Subsequently	subsequently	RB
cord-012418-6ralcn8p	181	2	,	,	,
cord-012418-6ralcn8p	181	3	the	the	DT
cord-012418-6ralcn8p	181	4	remaining	remain	VBG
cord-012418-6ralcn8p	181	5	virus	virus	NN
cord-012418-6ralcn8p	181	6	-	-	HYPH
cord-012418-6ralcn8p	181	7	induced	induce	VBN
cord-012418-6ralcn8p	181	8	transcription	transcription	NN
cord-012418-6ralcn8p	181	9	factors	factor	NNS
cord-012418-6ralcn8p	181	10	are	be	VBP
cord-012418-6ralcn8p	181	11	recruited	recruit	VBN
cord-012418-6ralcn8p	181	12	.	.	.
cord-012418-6ralcn8p	182	1	A	a	DT
cord-012418-6ralcn8p	182	2	second	second	JJ
cord-012418-6ralcn8p	182	3	HMG	HMG	NNP
cord-012418-6ralcn8p	182	4	I(Y	I(Y	NNP
cord-012418-6ralcn8p	182	5	)	)	-RRB-
cord-012418-6ralcn8p	182	6	molecule	molecule	NN
cord-012418-6ralcn8p	182	7	interacts	interact	VBZ
cord-012418-6ralcn8p	182	8	with	with	IN
cord-012418-6ralcn8p	182	9	ATF2-c	ATF2-c	NNP
cord-012418-6ralcn8p	182	10	-	-	HYPH
cord-012418-6ralcn8p	182	11	Jun	Jun	NNP
cord-012418-6ralcn8p	182	12	to	to	TO
cord-012418-6ralcn8p	182	13	promote	promote	VB
cord-012418-6ralcn8p	182	14	binding	binding	NN
cord-012418-6ralcn8p	182	15	of	of	IN
cord-012418-6ralcn8p	182	16	the	the	DT
cord-012418-6ralcn8p	182	17	heterodimer	heterodimer	NN
cord-012418-6ralcn8p	182	18	to	to	IN
cord-012418-6ralcn8p	182	19	PRDV	PRDV	NNP
cord-012418-6ralcn8p	182	20	by	by	IN
cord-012418-6ralcn8p	182	21	straightening	straighten	VBG
cord-012418-6ralcn8p	182	22	the	the	DT
cord-012418-6ralcn8p	182	23	DNA	dna	NN
cord-012418-6ralcn8p	182	24	helix	helix	NN
cord-012418-6ralcn8p	182	25	[	[	-LRB-
cord-012418-6ralcn8p	182	26	69	69	CD
cord-012418-6ralcn8p	182	27	,	,	,
cord-012418-6ralcn8p	182	28	88	88	CD
cord-012418-6ralcn8p	182	29	,	,	,
cord-012418-6ralcn8p	182	30	89	89	CD
cord-012418-6ralcn8p	182	31	]	]	-RRB-
cord-012418-6ralcn8p	182	32	.	.	.
cord-012418-6ralcn8p	183	1	Additionally	additionally	RB
cord-012418-6ralcn8p	183	2	,	,	,
cord-012418-6ralcn8p	183	3	NF	NF	NNP
cord-012418-6ralcn8p	183	4	-	-	HYPH
cord-012418-6ralcn8p	183	5	κB	κB	NNP
cord-012418-6ralcn8p	183	6	mediates	mediate	VBZ
cord-012418-6ralcn8p	183	7	capture	capture	NN
cord-012418-6ralcn8p	183	8	and	and	CC
cord-012418-6ralcn8p	183	9	binding	binding	NN
cord-012418-6ralcn8p	183	10	of	of	IN
cord-012418-6ralcn8p	183	11	the	the	DT
cord-012418-6ralcn8p	184	1	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	184	2	/	/	SYM
cord-012418-6ralcn8p	184	3	p300	p300	NNP
cord-012418-6ralcn8p	184	4	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	184	5	[	[	-LRB-
cord-012418-6ralcn8p	184	6	38	38	CD
cord-012418-6ralcn8p	184	7	,	,	,
cord-012418-6ralcn8p	184	8	90	90	CD
cord-012418-6ralcn8p	184	9	]	]	-RRB-
cord-012418-6ralcn8p	184	10	.	.	.
cord-012418-6ralcn8p	185	1	In	in	IN
cord-012418-6ralcn8p	185	2	vitro	vitro	FW
cord-012418-6ralcn8p	185	3	,	,	,
cord-012418-6ralcn8p	185	4	IRF3	IRF3	NNP
cord-012418-6ralcn8p	185	5	displays	display	VBZ
cord-012418-6ralcn8p	185	6	a	a	DT
cord-012418-6ralcn8p	185	7	surprisingly	surprisingly	RB
cord-012418-6ralcn8p	185	8	weak	weak	JJ
cord-012418-6ralcn8p	185	9	affinity	affinity	NN
cord-012418-6ralcn8p	185	10	for	for	IN
cord-012418-6ralcn8p	185	11	P31	P31	NNP
cord-012418-6ralcn8p	185	12	,	,	,
cord-012418-6ralcn8p	185	13	which	which	WDT
cord-012418-6ralcn8p	185	14	led	lead	VBD
cord-012418-6ralcn8p	185	15	to	to	IN
cord-012418-6ralcn8p	185	16	the	the	DT
cord-012418-6ralcn8p	185	17	former	former	JJ
cord-012418-6ralcn8p	185	18	model	model	NN
cord-012418-6ralcn8p	185	19	in	in	IN
cord-012418-6ralcn8p	185	20	which	which	WDT
cord-012418-6ralcn8p	185	21	IRF1	IRF1	NNP
cord-012418-6ralcn8p	185	22	is	be	VBZ
cord-012418-6ralcn8p	185	23	the	the	DT
cord-012418-6ralcn8p	185	24	critical	critical	JJ
cord-012418-6ralcn8p	185	25	IRF	IRF	NNP
cord-012418-6ralcn8p	185	26	member	member	NN
cord-012418-6ralcn8p	185	27	in	in	IN
cord-012418-6ralcn8p	185	28	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	185	29	induction	induction	NN
cord-012418-6ralcn8p	185	30	because	because	IN
cord-012418-6ralcn8p	185	31	it	-PRON-	PRP
cord-012418-6ralcn8p	185	32	freely	freely	RB
cord-012418-6ralcn8p	185	33	associates	associate	VBZ
cord-012418-6ralcn8p	185	34	with	with	IN
cord-012418-6ralcn8p	185	35	the	the	DT
cord-012418-6ralcn8p	185	36	enhancer	enhancer	NN
cord-012418-6ralcn8p	185	37	sequence	sequence	NN
cord-012418-6ralcn8p	185	38	[	[	-LRB-
cord-012418-6ralcn8p	185	39	91	91	CD
cord-012418-6ralcn8p	185	40	]	]	-RRB-
cord-012418-6ralcn8p	185	41	[	[	-LRB-
cord-012418-6ralcn8p	185	42	92	92	CD
cord-012418-6ralcn8p	185	43	]	]	-RRB-
cord-012418-6ralcn8p	186	1	[	[	-LRB-
cord-012418-6ralcn8p	186	2	93	93	CD
cord-012418-6ralcn8p	186	3	]	]	-RRB-
cord-012418-6ralcn8p	186	4	.	.	.
cord-012418-6ralcn8p	187	1	However	however	RB
cord-012418-6ralcn8p	187	2	,	,	,
cord-012418-6ralcn8p	187	3	IRF1	IRF1	NNP
cord-012418-6ralcn8p	187	4	was	be	VBD
cord-012418-6ralcn8p	187	5	then	then	RB
cord-012418-6ralcn8p	187	6	found	find	VBN
cord-012418-6ralcn8p	187	7	to	to	TO
cord-012418-6ralcn8p	187	8	be	be	VB
cord-012418-6ralcn8p	187	9	dispensable	dispensable	JJ
cord-012418-6ralcn8p	187	10	for	for	IN
cord-012418-6ralcn8p	187	11	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	187	12	expression	expression	NN
cord-012418-6ralcn8p	187	13	upon	upon	IN
cord-012418-6ralcn8p	187	14	PRR	PRR	NNP
cord-012418-6ralcn8p	187	15	activation	activation	NN
cord-012418-6ralcn8p	187	16	,	,	,
cord-012418-6ralcn8p	187	17	which	which	WDT
cord-012418-6ralcn8p	187	18	is	be	VBZ
cord-012418-6ralcn8p	187	19	congruent	congruent	JJ
cord-012418-6ralcn8p	187	20	with	with	IN
cord-012418-6ralcn8p	187	21	its	-PRON-	PRP$
cord-012418-6ralcn8p	187	22	expression	expression	NN
cord-012418-6ralcn8p	187	23	pattern	pattern	NN
cord-012418-6ralcn8p	187	24	as	as	IN
cord-012418-6ralcn8p	187	25	an	an	DT
cord-012418-6ralcn8p	187	26	ISG	ISG	NNP
cord-012418-6ralcn8p	187	27	[	[	-LRB-
cord-012418-6ralcn8p	187	28	94	94	CD
cord-012418-6ralcn8p	187	29	]	]	-RRB-
cord-012418-6ralcn8p	188	1	[	[	-LRB-
cord-012418-6ralcn8p	188	2	95	95	CD
cord-012418-6ralcn8p	188	3	]	]	-RRB-
cord-012418-6ralcn8p	188	4	[	[	-LRB-
cord-012418-6ralcn8p	188	5	96	96	CD
cord-012418-6ralcn8p	188	6	]	]	-RRB-
cord-012418-6ralcn8p	188	7	.	.	.
cord-012418-6ralcn8p	189	1	Instead	instead	RB
cord-012418-6ralcn8p	189	2	,	,	,
cord-012418-6ralcn8p	189	3	when	when	WRB
cord-012418-6ralcn8p	189	4	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	189	5	releases	release	VBZ
cord-012418-6ralcn8p	189	6	the	the	DT
cord-012418-6ralcn8p	189	7	auto	auto	NN
cord-012418-6ralcn8p	189	8	-	-	HYPH
cord-012418-6ralcn8p	189	9	inhibition	inhibition	NN
cord-012418-6ralcn8p	189	10	of	of	IN
cord-012418-6ralcn8p	189	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	189	12	and	and	CC
cord-012418-6ralcn8p	189	13	enables	enable	VBZ
cord-012418-6ralcn8p	189	14	interaction	interaction	NN
cord-012418-6ralcn8p	189	15	with	with	IN
cord-012418-6ralcn8p	189	16	CBP	CBP	NNP
cord-012418-6ralcn8p	189	17	/	/	SYM
cord-012418-6ralcn8p	189	18	p300	p300	NNP
cord-012418-6ralcn8p	189	19	,	,	,
cord-012418-6ralcn8p	189	20	the	the	DT
cord-012418-6ralcn8p	189	21	coactivator	coactivator	NN
cord-012418-6ralcn8p	189	22	strongly	strongly	RB
cord-012418-6ralcn8p	189	23	increases	increase	VBZ
cord-012418-6ralcn8p	189	24	the	the	DT
cord-012418-6ralcn8p	189	25	affinity	affinity	NN
cord-012418-6ralcn8p	189	26	of	of	IN
cord-012418-6ralcn8p	189	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	189	28	for	for	IN
cord-012418-6ralcn8p	189	29	DNA	DNA	NNP
cord-012418-6ralcn8p	189	30	and	and	CC
cord-012418-6ralcn8p	189	31	enables	enable	VBZ
cord-012418-6ralcn8p	189	32	association	association	NN
cord-012418-6ralcn8p	189	33	of	of	IN
cord-012418-6ralcn8p	189	34	the	the	DT
cord-012418-6ralcn8p	189	35	complex	complex	JJ
cord-012418-6ralcn8p	189	36	[	[	-LRB-
cord-012418-6ralcn8p	189	37	18	18	CD
cord-012418-6ralcn8p	189	38	,	,	,
cord-012418-6ralcn8p	189	39	38	38	CD
cord-012418-6ralcn8p	189	40	,	,	,
cord-012418-6ralcn8p	189	41	54	54	CD
cord-012418-6ralcn8p	189	42	,	,	,
cord-012418-6ralcn8p	189	43	55	55	CD
cord-012418-6ralcn8p	189	44	]	]	-RRB-
cord-012418-6ralcn8p	189	45	.	.	.
cord-012418-6ralcn8p	190	1	Further	further	JJ
cord-012418-6ralcn8p	190	2	cooperativity	cooperativity	NN
cord-012418-6ralcn8p	190	3	is	be	VBZ
cord-012418-6ralcn8p	190	4	mediated	mediate	VBN
cord-012418-6ralcn8p	190	5	by	by	IN
cord-012418-6ralcn8p	190	6	the	the	DT
cord-012418-6ralcn8p	190	7	P31	P31	NNP
cord-012418-6ralcn8p	190	8	sequence	sequence	NN
cord-012418-6ralcn8p	190	9	that	that	WDT
cord-012418-6ralcn8p	190	10	ensures	ensure	VBZ
cord-012418-6ralcn8p	190	11	concerted	concerted	JJ
cord-012418-6ralcn8p	190	12	binding	binding	NN
cord-012418-6ralcn8p	190	13	of	of	IN
cord-012418-6ralcn8p	190	14	ATF2-c	ATF2-c	NNP
cord-012418-6ralcn8p	190	15	-	-	HYPH
cord-012418-6ralcn8p	190	16	Jun	Jun	NNP
cord-012418-6ralcn8p	190	17	and	and	CC
cord-012418-6ralcn8p	190	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	190	19	[	[	-LRB-
cord-012418-6ralcn8p	190	20	97	97	CD
cord-012418-6ralcn8p	190	21	,	,	,
cord-012418-6ralcn8p	190	22	98	98	CD
cord-012418-6ralcn8p	190	23	]	]	-RRB-
cord-012418-6ralcn8p	190	24	and	and	CC
cord-012418-6ralcn8p	190	25	by	by	IN
cord-012418-6ralcn8p	190	26	CBP	CBP	NNP
cord-012418-6ralcn8p	190	27	/	/	SYM
cord-012418-6ralcn8p	190	28	p300-mediated	p300-mediate	VBN
cord-012418-6ralcn8p	190	29	interactions	interaction	NNS
cord-012418-6ralcn8p	190	30	within	within	IN
cord-012418-6ralcn8p	190	31	the	the	DT
cord-012418-6ralcn8p	190	32	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	190	33	complex	complex	NN
cord-012418-6ralcn8p	190	34	[	[	-LRB-
cord-012418-6ralcn8p	190	35	38	38	CD
cord-012418-6ralcn8p	190	36	,	,	,
cord-012418-6ralcn8p	190	37	90	90	CD
cord-012418-6ralcn8p	190	38	]	]	-RRB-
cord-012418-6ralcn8p	190	39	.	.	.
cord-012418-6ralcn8p	191	1	Clustering	clustering	NN
cord-012418-6ralcn8p	191	2	of	of	IN
cord-012418-6ralcn8p	191	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	191	4	target	target	NN
cord-012418-6ralcn8p	191	5	regions	region	NNS
cord-012418-6ralcn8p	191	6	with	with	IN
cord-012418-6ralcn8p	191	7	binding	bind	VBG
cord-012418-6ralcn8p	191	8	motifs	motif	NNS
cord-012418-6ralcn8p	191	9	for	for	IN
cord-012418-6ralcn8p	191	10	NF	nf	NN
cord-012418-6ralcn8p	191	11	-	-	HYPH
cord-012418-6ralcn8p	191	12	κB	κB	NNP
cord-012418-6ralcn8p	191	13	or	or	CC
cord-012418-6ralcn8p	191	14	other	other	JJ
cord-012418-6ralcn8p	191	15	transcription	transcription	NN
cord-012418-6ralcn8p	191	16	factors	factor	NNS
cord-012418-6ralcn8p	191	17	along	along	IN
cord-012418-6ralcn8p	191	18	with	with	IN
cord-012418-6ralcn8p	191	19	low	low	JJ
cord-012418-6ralcn8p	191	20	chromatin	chromatin	NN
cord-012418-6ralcn8p	191	21	accessibility	accessibility	NN
cord-012418-6ralcn8p	191	22	in	in	IN
cord-012418-6ralcn8p	191	23	steady	steady	JJ
cord-012418-6ralcn8p	191	24	-	-	HYPH
cord-012418-6ralcn8p	191	25	state	state	NN
cord-012418-6ralcn8p	191	26	conditions	condition	NNS
cord-012418-6ralcn8p	191	27	was	be	VBD
cord-012418-6ralcn8p	191	28	recently	recently	RB
cord-012418-6ralcn8p	191	29	described	describe	VBN
cord-012418-6ralcn8p	191	30	as	as	IN
cord-012418-6ralcn8p	191	31	a	a	DT
cord-012418-6ralcn8p	191	32	common	common	JJ
cord-012418-6ralcn8p	191	33	feature	feature	NN
cord-012418-6ralcn8p	191	34	of	of	IN
cord-012418-6ralcn8p	191	35	IRF3-DNA	IRF3-DNA	NNP
cord-012418-6ralcn8p	191	36	interactions	interaction	NNS
cord-012418-6ralcn8p	191	37	,	,	,
cord-012418-6ralcn8p	191	38	implying	imply	VBG
cord-012418-6ralcn8p	191	39	an	an	DT
cord-012418-6ralcn8p	191	40	obligatory	obligatory	JJ
cord-012418-6ralcn8p	191	41	collaborative	collaborative	JJ
cord-012418-6ralcn8p	191	42	binding	binding	NN
cord-012418-6ralcn8p	191	43	mode	mode	NN
cord-012418-6ralcn8p	191	44	of	of	IN
cord-012418-6ralcn8p	191	45	IRF3	IRF3	NNP
cord-012418-6ralcn8p	191	46	that	that	WDT
cord-012418-6ralcn8p	191	47	promotes	promote	VBZ
cord-012418-6ralcn8p	191	48	access	access	NN
cord-012418-6ralcn8p	191	49	to	to	IN
cord-012418-6ralcn8p	191	50	chromatin	chromatin	NN
cord-012418-6ralcn8p	191	51	[	[	-LRB-
cord-012418-6ralcn8p	191	52	82	82	CD
cord-012418-6ralcn8p	191	53	]	]	-RRB-
cord-012418-6ralcn8p	191	54	.	.	.
cord-012418-6ralcn8p	192	1	At	at	IN
cord-012418-6ralcn8p	192	2	the	the	DT
cord-012418-6ralcn8p	192	3	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	192	4	enhancer	enhancer	NN
cord-012418-6ralcn8p	192	5	,	,	,
cord-012418-6ralcn8p	192	6	a	a	DT
cord-012418-6ralcn8p	192	7	total	total	NN
cord-012418-6ralcn8p	192	8	of	of	IN
cord-012418-6ralcn8p	192	9	four	four	CD
cord-012418-6ralcn8p	192	10	IRF3/7	IRF3/7	NNP
cord-012418-6ralcn8p	192	11	molecules	molecule	NNS
cord-012418-6ralcn8p	192	12	bound	bind	VBN
cord-012418-6ralcn8p	192	13	to	to	IN
cord-012418-6ralcn8p	192	14	four	four	CD
cord-012418-6ralcn8p	192	15	IRF	IRF	NNP
cord-012418-6ralcn8p	192	16	-	-	HYPH
cord-012418-6ralcn8p	192	17	Es	Es	NNP
cord-012418-6ralcn8p	192	18	in	in	IN
cord-012418-6ralcn8p	192	19	tandem	tandem	NN
cord-012418-6ralcn8p	192	20	are	be	VBP
cord-012418-6ralcn8p	192	21	required	require	VBN
cord-012418-6ralcn8p	192	22	to	to	TO
cord-012418-6ralcn8p	192	23	induce	induce	VB
cord-012418-6ralcn8p	192	24	gene	gene	NN
cord-012418-6ralcn8p	192	25	expression	expression	NN
cord-012418-6ralcn8p	192	26	of	of	IN
cord-012418-6ralcn8p	192	27	a	a	DT
cord-012418-6ralcn8p	192	28	luciferase	luciferase	NN
cord-012418-6ralcn8p	192	29	-	-	HYPH
cord-012418-6ralcn8p	192	30	based	base	VBN
cord-012418-6ralcn8p	192	31	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	192	32	-	-	HYPH
cord-012418-6ralcn8p	192	33	reporter	reporter	NN
cord-012418-6ralcn8p	192	34	plasmid	plasmid	NN
cord-012418-6ralcn8p	192	35	in	in	IN
cord-012418-6ralcn8p	192	36	the	the	DT
cord-012418-6ralcn8p	192	37	commonly	commonly	RB
cord-012418-6ralcn8p	192	38	used	use	VBN
cord-012418-6ralcn8p	192	39	human	human	JJ
cord-012418-6ralcn8p	192	40	embryonic	embryonic	JJ
cord-012418-6ralcn8p	192	41	kidney	kidney	NN
cord-012418-6ralcn8p	192	42	cell	cell	NN
cord-012418-6ralcn8p	192	43	line	line	NN
cord-012418-6ralcn8p	192	44	HEK293	HEK293	NNP
cord-012418-6ralcn8p	192	45	T	T	NNP
cord-012418-6ralcn8p	192	46	[	[	-LRB-
cord-012418-6ralcn8p	192	47	99	99	CD
cord-012418-6ralcn8p	192	48	]	]	-RRB-
cord-012418-6ralcn8p	192	49	.	.	.
cord-012418-6ralcn8p	193	1	Structural	structural	JJ
cord-012418-6ralcn8p	193	2	analysis	analysis	NN
cord-012418-6ralcn8p	193	3	suggests	suggest	VBZ
cord-012418-6ralcn8p	193	4	that	that	IN
cord-012418-6ralcn8p	193	5	one	one	CD
cord-012418-6ralcn8p	193	6	IRF	IRF	NNP
cord-012418-6ralcn8p	193	7	dimer	dimer	NN
cord-012418-6ralcn8p	193	8	binds	bind	VBZ
cord-012418-6ralcn8p	193	9	on	on	IN
cord-012418-6ralcn8p	193	10	one	one	CD
cord-012418-6ralcn8p	193	11	side	side	NN
cord-012418-6ralcn8p	193	12	of	of	IN
cord-012418-6ralcn8p	193	13	the	the	DT
cord-012418-6ralcn8p	193	14	duplex	duplex	NN
cord-012418-6ralcn8p	193	15	,	,	,
cord-012418-6ralcn8p	193	16	occupying	occupy	VBG
cord-012418-6ralcn8p	193	17	the	the	DT
cord-012418-6ralcn8p	193	18	first	first	JJ
cord-012418-6ralcn8p	193	19	and	and	CC
cord-012418-6ralcn8p	193	20	the	the	DT
cord-012418-6ralcn8p	193	21	third	third	JJ
cord-012418-6ralcn8p	193	22	IRF	IRF	NNP
cord-012418-6ralcn8p	193	23	-	-	HYPH
cord-012418-6ralcn8p	193	24	E	E	NNP
cord-012418-6ralcn8p	193	25	,	,	,
cord-012418-6ralcn8p	193	26	and	and	CC
cord-012418-6ralcn8p	193	27	the	the	DT
cord-012418-6ralcn8p	193	28	second	second	JJ
cord-012418-6ralcn8p	193	29	dimer	dimer	NN
cord-012418-6ralcn8p	193	30	binds	bind	VBZ
cord-012418-6ralcn8p	193	31	from	from	IN
cord-012418-6ralcn8p	193	32	the	the	DT
cord-012418-6ralcn8p	193	33	opposite	opposite	JJ
cord-012418-6ralcn8p	193	34	side	side	NN
cord-012418-6ralcn8p	193	35	,	,	,
cord-012418-6ralcn8p	193	36	binding	bind	VBG
cord-012418-6ralcn8p	193	37	to	to	IN
cord-012418-6ralcn8p	193	38	the	the	DT
cord-012418-6ralcn8p	193	39	second	second	JJ
cord-012418-6ralcn8p	193	40	and	and	CC
cord-012418-6ralcn8p	193	41	fourth	fourth	JJ
cord-012418-6ralcn8p	193	42	IRF	IRF	NNP
cord-012418-6ralcn8p	193	43	-	-	HYPH
cord-012418-6ralcn8p	193	44	E	E	NNP
cord-012418-6ralcn8p	193	45	[	[	-LRB-
cord-012418-6ralcn8p	193	46	81	81	CD
cord-012418-6ralcn8p	193	47	]	]	-RRB-
cord-012418-6ralcn8p	193	48	.	.	.
cord-012418-6ralcn8p	194	1	Remarkably	remarkably	RB
cord-012418-6ralcn8p	194	2	,	,	,
cord-012418-6ralcn8p	194	3	the	the	DT
cord-012418-6ralcn8p	194	4	DBDs	dbd	NNS
cord-012418-6ralcn8p	194	5	of	of	IN
cord-012418-6ralcn8p	194	6	the	the	DT
cord-012418-6ralcn8p	194	7	eight	eight	CD
cord-012418-6ralcn8p	194	8	transcription	transcription	NN
cord-012418-6ralcn8p	194	9	factors	factor	NNS
cord-012418-6ralcn8p	194	10	barely	barely	RB
cord-012418-6ralcn8p	194	11	interact	interact	VBP
cord-012418-6ralcn8p	194	12	with	with	IN
cord-012418-6ralcn8p	194	13	each	each	DT
cord-012418-6ralcn8p	194	14	other	other	JJ
cord-012418-6ralcn8p	194	15	despite	despite	IN
cord-012418-6ralcn8p	194	16	the	the	DT
cord-012418-6ralcn8p	194	17	great	great	JJ
cord-012418-6ralcn8p	194	18	overlap	overlap	NN
cord-012418-6ralcn8p	194	19	of	of	IN
cord-012418-6ralcn8p	194	20	their	-PRON-	PRP$
cord-012418-6ralcn8p	194	21	binding	bind	VBG
cord-012418-6ralcn8p	194	22	elements	element	NNS
cord-012418-6ralcn8p	194	23	[	[	-LRB-
cord-012418-6ralcn8p	194	24	81	81	CD
cord-012418-6ralcn8p	194	25	]	]	-RRB-
cord-012418-6ralcn8p	194	26	.	.	.
cord-012418-6ralcn8p	195	1	Instead	instead	RB
cord-012418-6ralcn8p	195	2	,	,	,
cord-012418-6ralcn8p	195	3	the	the	DT
cord-012418-6ralcn8p	195	4	high	high	JJ
cord-012418-6ralcn8p	195	5	level	level	NN
cord-012418-6ralcn8p	195	6	of	of	IN
cord-012418-6ralcn8p	195	7	cooperativity	cooperativity	NN
cord-012418-6ralcn8p	195	8	between	between	IN
cord-012418-6ralcn8p	195	9	binding	bind	VBG
cord-012418-6ralcn8p	195	10	events	event	NNS
cord-012418-6ralcn8p	195	11	is	be	VBZ
cord-012418-6ralcn8p	195	12	achieved	achieve	VBN
cord-012418-6ralcn8p	195	13	by	by	IN
cord-012418-6ralcn8p	195	14	the	the	DT
cord-012418-6ralcn8p	195	15	specific	specific	JJ
cord-012418-6ralcn8p	195	16	order	order	NN
cord-012418-6ralcn8p	195	17	of	of	IN
cord-012418-6ralcn8p	195	18	individual	individual	JJ
cord-012418-6ralcn8p	195	19	response	response	NN
cord-012418-6ralcn8p	195	20	elements	element	NNS
cord-012418-6ralcn8p	195	21	that	that	WDT
cord-012418-6ralcn8p	195	22	allows	allow	VBZ
cord-012418-6ralcn8p	195	23	for	for	IN
cord-012418-6ralcn8p	195	24	binding	bind	VBG
cord-012418-6ralcn8p	195	25	-	-	HYPH
cord-012418-6ralcn8p	195	26	induced	induce	VBN
cord-012418-6ralcn8p	195	27	conformational	conformational	JJ
cord-012418-6ralcn8p	195	28	changes	change	NNS
cord-012418-6ralcn8p	195	29	of	of	IN
cord-012418-6ralcn8p	195	30	the	the	DT
cord-012418-6ralcn8p	195	31	DNA	dna	NN
cord-012418-6ralcn8p	195	32	to	to	TO
cord-012418-6ralcn8p	195	33	transmit	transmit	VB
cord-012418-6ralcn8p	195	34	allosteric	allosteric	JJ
cord-012418-6ralcn8p	195	35	effects	effect	NNS
cord-012418-6ralcn8p	195	36	[	[	-LRB-
cord-012418-6ralcn8p	195	37	68	68	CD
cord-012418-6ralcn8p	195	38	,	,	,
cord-012418-6ralcn8p	195	39	74	74	CD
cord-012418-6ralcn8p	195	40	,	,	,
cord-012418-6ralcn8p	195	41	81	81	CD
cord-012418-6ralcn8p	195	42	,	,	,
cord-012418-6ralcn8p	195	43	100	100	CD
cord-012418-6ralcn8p	195	44	]	]	-RRB-
cord-012418-6ralcn8p	195	45	.	.	.
cord-012418-6ralcn8p	196	1	Molecular	molecular	JJ
cord-012418-6ralcn8p	196	2	dynamics	dynamic	NNS
cord-012418-6ralcn8p	196	3	simulations	simulation	NNS
cord-012418-6ralcn8p	196	4	by	by	IN
cord-012418-6ralcn8p	196	5	Pan	Pan	NNP
cord-012418-6ralcn8p	196	6	and	and	CC
cord-012418-6ralcn8p	196	7	Nussinov	Nussinov	NNP
cord-012418-6ralcn8p	196	8	further	further	RB
cord-012418-6ralcn8p	196	9	showed	show	VBD
cord-012418-6ralcn8p	196	10	that	that	IN
cord-012418-6ralcn8p	196	11	the	the	DT
cord-012418-6ralcn8p	196	12	combination	combination	NN
cord-012418-6ralcn8p	196	13	of	of	IN
cord-012418-6ralcn8p	196	14	overlapping	overlap	VBG
cord-012418-6ralcn8p	196	15	recognition	recognition	NN
cord-012418-6ralcn8p	196	16	Viruses	virus	NNS
cord-012418-6ralcn8p	196	17	2020	2020	CD
cord-012418-6ralcn8p	196	18	,	,	,
cord-012418-6ralcn8p	196	19	12	12	CD
cord-012418-6ralcn8p	196	20	,	,	,
cord-012418-6ralcn8p	196	21	733	733	CD
cord-012418-6ralcn8p	196	22	9	9	CD
cord-012418-6ralcn8p	196	23	of	of	IN
cord-012418-6ralcn8p	196	24	33	33	CD
cord-012418-6ralcn8p	196	25	elements	element	NNS
cord-012418-6ralcn8p	196	26	with	with	IN
cord-012418-6ralcn8p	196	27	an	an	DT
cord-012418-6ralcn8p	196	28	alternation	alternation	NN
cord-012418-6ralcn8p	196	29	between	between	IN
cord-012418-6ralcn8p	196	30	consensus	consensus	NN
cord-012418-6ralcn8p	196	31	and	and	CC
cord-012418-6ralcn8p	196	32	non	non	JJ
cord-012418-6ralcn8p	196	33	-	-	JJ
cord-012418-6ralcn8p	196	34	consensus	consensus	JJ
cord-012418-6ralcn8p	196	35	motifs	motif	NNS
cord-012418-6ralcn8p	196	36	optimises	optimise	VBZ
cord-012418-6ralcn8p	196	37	the	the	DT
cord-012418-6ralcn8p	196	38	specific	specific	JJ
cord-012418-6ralcn8p	196	39	interactions	interaction	NNS
cord-012418-6ralcn8p	196	40	by	by	IN
cord-012418-6ralcn8p	196	41	enhancing	enhance	VBG
cord-012418-6ralcn8p	196	42	or	or	CC
cord-012418-6ralcn8p	196	43	restricting	restrict	VBG
cord-012418-6ralcn8p	196	44	binding	binding	NN
cord-012418-6ralcn8p	196	45	of	of	IN
cord-012418-6ralcn8p	196	46	neighbouring	neighbour	VBG
cord-012418-6ralcn8p	196	47	transcription	transcription	NN
cord-012418-6ralcn8p	196	48	factors	factor	NNS
cord-012418-6ralcn8p	196	49	.	.	.
cord-012418-6ralcn8p	197	1	Moreover	moreover	RB
cord-012418-6ralcn8p	197	2	,	,	,
cord-012418-6ralcn8p	197	3	the	the	DT
cord-012418-6ralcn8p	197	4	signal	signal	NN
cord-012418-6ralcn8p	197	5	integration	integration	NN
cord-012418-6ralcn8p	197	6	by	by	IN
cord-012418-6ralcn8p	197	7	CBP	CBP	NNP
cord-012418-6ralcn8p	197	8	/	/	SYM
cord-012418-6ralcn8p	197	9	p300	p300	NNP
cord-012418-6ralcn8p	197	10	that	that	WDT
cord-012418-6ralcn8p	197	11	interacts	interact	VBZ
cord-012418-6ralcn8p	197	12	with	with	IN
cord-012418-6ralcn8p	197	13	each	each	DT
cord-012418-6ralcn8p	197	14	transcription	transcription	NN
cord-012418-6ralcn8p	197	15	factor	factor	NN
cord-012418-6ralcn8p	197	16	through	through	IN
cord-012418-6ralcn8p	197	17	different	different	JJ
cord-012418-6ralcn8p	197	18	domains	domain	NNS
cord-012418-6ralcn8p	197	19	is	be	VBZ
cord-012418-6ralcn8p	197	20	essential	essential	JJ
cord-012418-6ralcn8p	197	21	for	for	IN
cord-012418-6ralcn8p	197	22	the	the	DT
cord-012418-6ralcn8p	197	23	functionality	functionality	NN
cord-012418-6ralcn8p	197	24	of	of	IN
cord-012418-6ralcn8p	197	25	the	the	DT
cord-012418-6ralcn8p	197	26	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	197	27	[	[	-LRB-
cord-012418-6ralcn8p	197	28	90	90	CD
cord-012418-6ralcn8p	197	29	]	]	-RRB-
cord-012418-6ralcn8p	197	30	.	.	.
cord-012418-6ralcn8p	198	1	In	in	IN
cord-012418-6ralcn8p	198	2	addition	addition	NN
cord-012418-6ralcn8p	198	3	to	to	IN
cord-012418-6ralcn8p	198	4	the	the	DT
cord-012418-6ralcn8p	198	5	pivotal	pivotal	JJ
cord-012418-6ralcn8p	198	6	architectural	architectural	JJ
cord-012418-6ralcn8p	198	7	role	role	NN
cord-012418-6ralcn8p	198	8	of	of	IN
cord-012418-6ralcn8p	198	9	recruiting	recruit	VBG
cord-012418-6ralcn8p	198	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	198	11	and	and	CC
cord-012418-6ralcn8p	198	12	mediating	mediate	VBG
cord-012418-6ralcn8p	198	13	interactions	interaction	NNS
cord-012418-6ralcn8p	198	14	with	with	IN
cord-012418-6ralcn8p	198	15	the	the	DT
cord-012418-6ralcn8p	198	16	transcription	transcription	NN
cord-012418-6ralcn8p	198	17	machinery	machinery	NN
cord-012418-6ralcn8p	198	18	as	as	IN
cord-012418-6ralcn8p	198	19	coactivator	coactivator	NN
cord-012418-6ralcn8p	198	20	,	,	,
cord-012418-6ralcn8p	198	21	CBP	CBP	NNP
cord-012418-6ralcn8p	198	22	/	/	SYM
cord-012418-6ralcn8p	198	23	p300	p300	NNP
cord-012418-6ralcn8p	198	24	also	also	RB
cord-012418-6ralcn8p	198	25	participates	participate	VBZ
cord-012418-6ralcn8p	198	26	in	in	IN
cord-012418-6ralcn8p	198	27	the	the	DT
cord-012418-6ralcn8p	198	28	subsequent	subsequent	JJ
cord-012418-6ralcn8p	198	29	chromatin	chromatin	NN
cord-012418-6ralcn8p	198	30	remodelling	remodelling	NN
cord-012418-6ralcn8p	198	31	in	in	IN
cord-012418-6ralcn8p	198	32	its	-PRON-	PRP$
cord-012418-6ralcn8p	198	33	vicinity	vicinity	NN
cord-012418-6ralcn8p	198	34	[	[	-LRB-
cord-012418-6ralcn8p	198	35	71	71	CD
cord-012418-6ralcn8p	198	36	,	,	,
cord-012418-6ralcn8p	198	37	101	101	CD
cord-012418-6ralcn8p	198	38	,	,	,
cord-012418-6ralcn8p	198	39	102	102	CD
cord-012418-6ralcn8p	198	40	]	]	-RRB-
cord-012418-6ralcn8p	198	41	.	.	.
cord-012418-6ralcn8p	199	1	As	as	IN
cord-012418-6ralcn8p	199	2	implied	imply	VBN
cord-012418-6ralcn8p	199	3	above	above	RB
cord-012418-6ralcn8p	199	4	,	,	,
cord-012418-6ralcn8p	199	5	however	however	RB
cord-012418-6ralcn8p	199	6	,	,	,
cord-012418-6ralcn8p	199	7	the	the	DT
cord-012418-6ralcn8p	199	8	precise	precise	JJ
cord-012418-6ralcn8p	199	9	number	number	NN
cord-012418-6ralcn8p	199	10	and	and	CC
cord-012418-6ralcn8p	199	11	identity	identity	NN
cord-012418-6ralcn8p	199	12	of	of	IN
cord-012418-6ralcn8p	199	13	coactivator	coactivator	NN
cord-012418-6ralcn8p	199	14	molecules	molecule	NNS
cord-012418-6ralcn8p	199	15	participating	participate	VBG
cord-012418-6ralcn8p	199	16	in	in	IN
cord-012418-6ralcn8p	199	17	the	the	DT
cord-012418-6ralcn8p	199	18	formation	formation	NN
cord-012418-6ralcn8p	199	19	of	of	IN
cord-012418-6ralcn8p	199	20	the	the	DT
cord-012418-6ralcn8p	199	21	active	active	JJ
cord-012418-6ralcn8p	199	22	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	199	23	/	/	SYM
cord-012418-6ralcn8p	199	24	p300	p300	NNP
cord-012418-6ralcn8p	199	25	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	199	26	as	as	RB
cord-012418-6ralcn8p	199	27	well	well	RB
cord-012418-6ralcn8p	199	28	as	as	IN
cord-012418-6ralcn8p	199	29	in	in	IN
cord-012418-6ralcn8p	199	30	the	the	DT
cord-012418-6ralcn8p	199	31	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	199	32	is	be	VBZ
cord-012418-6ralcn8p	199	33	unknown	unknown	JJ
cord-012418-6ralcn8p	199	34	.	.	.
cord-012418-6ralcn8p	200	1	Potentially	potentially	RB
cord-012418-6ralcn8p	200	2	,	,	,
cord-012418-6ralcn8p	200	3	they	-PRON-	PRP
cord-012418-6ralcn8p	200	4	present	present	VBP
cord-012418-6ralcn8p	200	5	a	a	DT
cord-012418-6ralcn8p	200	6	module	module	NN
cord-012418-6ralcn8p	200	7	for	for	IN
cord-012418-6ralcn8p	200	8	further	further	JJ
cord-012418-6ralcn8p	200	9	signal	signal	NN
cord-012418-6ralcn8p	200	10	integration	integration	NN
cord-012418-6ralcn8p	200	11	by	by	IN
cord-012418-6ralcn8p	200	12	participating	participate	VBG
cord-012418-6ralcn8p	200	13	in	in	IN
cord-012418-6ralcn8p	200	14	dynamic	dynamic	JJ
cord-012418-6ralcn8p	200	15	compositions	composition	NNS
cord-012418-6ralcn8p	200	16	.	.	.
cord-012418-6ralcn8p	201	1	Further	further	RB
cord-012418-6ralcn8p	201	2	,	,	,
cord-012418-6ralcn8p	201	3	also	also	RB
cord-012418-6ralcn8p	201	4	the	the	DT
cord-012418-6ralcn8p	201	5	subtle	subtle	JJ
cord-012418-6ralcn8p	201	6	modulation	modulation	NN
cord-012418-6ralcn8p	201	7	by	by	IN
cord-012418-6ralcn8p	201	8	the	the	DT
cord-012418-6ralcn8p	201	9	two	two	CD
cord-012418-6ralcn8p	201	10	HMG	HMG	NNP
cord-012418-6ralcn8p	201	11	I(Y	I(Y	NNP
cord-012418-6ralcn8p	201	12	)	)	-RRB-
cord-012418-6ralcn8p	201	13	proteins	protein	NNS
cord-012418-6ralcn8p	201	14	is	be	VBZ
cord-012418-6ralcn8p	201	15	required	require	VBN
cord-012418-6ralcn8p	201	16	for	for	IN
cord-012418-6ralcn8p	201	17	the	the	DT
cord-012418-6ralcn8p	201	18	maximal	maximal	JJ
cord-012418-6ralcn8p	201	19	level	level	NN
cord-012418-6ralcn8p	201	20	of	of	IN
cord-012418-6ralcn8p	201	21	expression	expression	NN
cord-012418-6ralcn8p	201	22	[	[	-LRB-
cord-012418-6ralcn8p	201	23	86	86	CD
cord-012418-6ralcn8p	201	24	]	]	-RRB-
cord-012418-6ralcn8p	201	25	,	,	,
cord-012418-6ralcn8p	201	26	though	though	IN
cord-012418-6ralcn8p	201	27	their	-PRON-	PRP$
cord-012418-6ralcn8p	201	28	participation	participation	NN
cord-012418-6ralcn8p	201	29	in	in	IN
cord-012418-6ralcn8p	201	30	the	the	DT
cord-012418-6ralcn8p	201	31	final	final	JJ
cord-012418-6ralcn8p	201	32	assembly	assembly	NN
cord-012418-6ralcn8p	201	33	is	be	VBZ
cord-012418-6ralcn8p	201	34	controversial	controversial	JJ
cord-012418-6ralcn8p	201	35	as	as	IN
cord-012418-6ralcn8p	201	36	previously	previously	RB
cord-012418-6ralcn8p	201	37	discussed	discuss	VBN
cord-012418-6ralcn8p	201	38	[	[	-LRB-
cord-012418-6ralcn8p	201	39	17	17	CD
cord-012418-6ralcn8p	201	40	]	]	-RRB-
cord-012418-6ralcn8p	201	41	.	.	.
cord-012418-6ralcn8p	202	1	In	in	IN
cord-012418-6ralcn8p	202	2	line	line	NN
cord-012418-6ralcn8p	202	3	with	with	IN
cord-012418-6ralcn8p	202	4	the	the	DT
cord-012418-6ralcn8p	202	5	high	high	JJ
cord-012418-6ralcn8p	202	6	synergy	synergy	NN
cord-012418-6ralcn8p	202	7	during	during	IN
cord-012418-6ralcn8p	202	8	assembly	assembly	NN
cord-012418-6ralcn8p	202	9	,	,	,
cord-012418-6ralcn8p	202	10	the	the	DT
cord-012418-6ralcn8p	202	11	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	202	12	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	202	13	is	be	VBZ
cord-012418-6ralcn8p	202	14	extraordinarily	extraordinarily	RB
cord-012418-6ralcn8p	202	15	stable	stable	JJ
cord-012418-6ralcn8p	202	16	and	and	CC
cord-012418-6ralcn8p	202	17	enables	enable	VBZ
cord-012418-6ralcn8p	202	18	multiple	multiple	JJ
cord-012418-6ralcn8p	202	19	rounds	round	NNS
cord-012418-6ralcn8p	202	20	of	of	IN
cord-012418-6ralcn8p	202	21	re	re	NN
cord-012418-6ralcn8p	202	22	-	-	NN
cord-012418-6ralcn8p	202	23	initiation	initiation	NN
cord-012418-6ralcn8p	202	24	in	in	IN
cord-012418-6ralcn8p	202	25	vitro	vitro	FW
cord-012418-6ralcn8p	202	26	[	[	-LRB-
cord-012418-6ralcn8p	202	27	70	70	CD
cord-012418-6ralcn8p	202	28	,	,	,
cord-012418-6ralcn8p	202	29	88	88	CD
cord-012418-6ralcn8p	202	30	]	]	-RRB-
cord-012418-6ralcn8p	202	31	.	.	.
cord-012418-6ralcn8p	203	1	Due	due	IN
cord-012418-6ralcn8p	203	2	to	to	IN
cord-012418-6ralcn8p	203	3	the	the	DT
cord-012418-6ralcn8p	203	4	binding	binding	NN
cord-012418-6ralcn8p	203	5	-	-	HYPH
cord-012418-6ralcn8p	203	6	induced	induce	VBN
cord-012418-6ralcn8p	203	7	conformational	conformational	JJ
cord-012418-6ralcn8p	203	8	changes	change	NNS
cord-012418-6ralcn8p	203	9	of	of	IN
cord-012418-6ralcn8p	203	10	the	the	DT
cord-012418-6ralcn8p	203	11	DNA	DNA	NNP
cord-012418-6ralcn8p	203	12	foundation	foundation	NN
cord-012418-6ralcn8p	203	13	,	,	,
cord-012418-6ralcn8p	203	14	the	the	DT
cord-012418-6ralcn8p	203	15	fully	fully	RB
cord-012418-6ralcn8p	203	16	assembled	assemble	VBN
cord-012418-6ralcn8p	203	17	structure	structure	NN
cord-012418-6ralcn8p	203	18	encompasses	encompass	VBZ
cord-012418-6ralcn8p	203	19	a	a	DT
cord-012418-6ralcn8p	203	20	straight	straight	JJ
cord-012418-6ralcn8p	203	21	segment	segment	NN
cord-012418-6ralcn8p	203	22	of	of	IN
cord-012418-6ralcn8p	203	23	DNA	dna	NN
cord-012418-6ralcn8p	203	24	covered	cover	VBN
cord-012418-6ralcn8p	203	25	by	by	IN
cord-012418-6ralcn8p	203	26	eight	eight	CD
cord-012418-6ralcn8p	203	27	specifically	specifically	RB
cord-012418-6ralcn8p	203	28	bound	bind	VBN
cord-012418-6ralcn8p	203	29	transcription	transcription	NN
cord-012418-6ralcn8p	203	30	factors	factor	NNS
cord-012418-6ralcn8p	203	31	all	all	DT
cord-012418-6ralcn8p	203	32	of	of	IN
cord-012418-6ralcn8p	203	33	which	which	WDT
cord-012418-6ralcn8p	203	34	interact	interact	VBP
cord-012418-6ralcn8p	203	35	with	with	IN
cord-012418-6ralcn8p	203	36	the	the	DT
cord-012418-6ralcn8p	203	37	essential	essential	JJ
cord-012418-6ralcn8p	203	38	coactivator	coactivator	NN
cord-012418-6ralcn8p	203	39	CBP	CBP	NNP
cord-012418-6ralcn8p	203	40	/	/	SYM
cord-012418-6ralcn8p	203	41	p300	p300	NNP
cord-012418-6ralcn8p	203	42	.	.	.
cord-012418-6ralcn8p	204	1	This	this	DT
cord-012418-6ralcn8p	204	2	final	final	JJ
cord-012418-6ralcn8p	204	3	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	204	4	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	204	5	presents	present	VBZ
cord-012418-6ralcn8p	204	6	a	a	DT
cord-012418-6ralcn8p	204	7	single	single	JJ
cord-012418-6ralcn8p	204	8	new	new	JJ
cord-012418-6ralcn8p	204	9	,	,	,
cord-012418-6ralcn8p	204	10	continuous	continuous	JJ
cord-012418-6ralcn8p	204	11	activating	activate	VBG
cord-012418-6ralcn8p	204	12	surface	surface	NN
cord-012418-6ralcn8p	204	13	and	and	CC
cord-012418-6ralcn8p	204	14	provides	provide	VBZ
cord-012418-6ralcn8p	204	15	the	the	DT
cord-012418-6ralcn8p	204	16	basis	basis	NN
cord-012418-6ralcn8p	204	17	for	for	IN
cord-012418-6ralcn8p	204	18	the	the	DT
cord-012418-6ralcn8p	204	19	association	association	NN
cord-012418-6ralcn8p	204	20	of	of	IN
cord-012418-6ralcn8p	204	21	the	the	DT
cord-012418-6ralcn8p	204	22	basal	basal	NN
cord-012418-6ralcn8p	204	23	transcription	transcription	NN
cord-012418-6ralcn8p	204	24	apparatus	apparatus	NN
cord-012418-6ralcn8p	204	25	.	.	.
cord-012418-6ralcn8p	205	1	Before	before	IN
cord-012418-6ralcn8p	205	2	transcription	transcription	NN
cord-012418-6ralcn8p	205	3	of	of	IN
cord-012418-6ralcn8p	205	4	the	the	DT
cord-012418-6ralcn8p	205	5	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	205	6	gene	gene	NN
cord-012418-6ralcn8p	205	7	can	can	MD
cord-012418-6ralcn8p	205	8	commence	commence	VB
cord-012418-6ralcn8p	205	9	,	,	,
cord-012418-6ralcn8p	205	10	the	the	DT
cord-012418-6ralcn8p	205	11	chromatin	chromatin	NN
cord-012418-6ralcn8p	205	12	landscape	landscape	NN
cord-012418-6ralcn8p	205	13	needs	need	VBZ
cord-012418-6ralcn8p	205	14	to	to	TO
cord-012418-6ralcn8p	205	15	be	be	VB
cord-012418-6ralcn8p	205	16	modified	modify	VBN
cord-012418-6ralcn8p	205	17	so	so	IN
cord-012418-6ralcn8p	205	18	that	that	IN
cord-012418-6ralcn8p	205	19	the	the	DT
cord-012418-6ralcn8p	205	20	pre	pre	JJ
cord-012418-6ralcn8p	205	21	-	-	NN
cord-012418-6ralcn8p	205	22	initiation	initiation	JJ
cord-012418-6ralcn8p	205	23	complex	complex	NN
cord-012418-6ralcn8p	205	24	can	can	MD
cord-012418-6ralcn8p	205	25	be	be	VB
cord-012418-6ralcn8p	205	26	assembled	assemble	VBN
cord-012418-6ralcn8p	205	27	and	and	CC
cord-012418-6ralcn8p	205	28	access	access	VB
cord-012418-6ralcn8p	205	29	the	the	DT
cord-012418-6ralcn8p	205	30	TSS	TSS	NNP
cord-012418-6ralcn8p	205	31	.	.	.
cord-012418-6ralcn8p	206	1	First	first	RB
cord-012418-6ralcn8p	206	2	,	,	,
cord-012418-6ralcn8p	206	3	the	the	DT
cord-012418-6ralcn8p	206	4	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	206	5	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	206	6	mediates	mediate	VBZ
cord-012418-6ralcn8p	206	7	the	the	DT
cord-012418-6ralcn8p	206	8	transient	transient	JJ
cord-012418-6ralcn8p	206	9	recruitment	recruitment	NN
cord-012418-6ralcn8p	206	10	of	of	IN
cord-012418-6ralcn8p	206	11	a	a	DT
cord-012418-6ralcn8p	206	12	complex	complex	NN
cord-012418-6ralcn8p	206	13	of	of	IN
cord-012418-6ralcn8p	206	14	p300	p300	NNP
cord-012418-6ralcn8p	206	15	/	/	SYM
cord-012418-6ralcn8p	206	16	CBP	CBP	NNP
cord-012418-6ralcn8p	206	17	-	-	HYPH
cord-012418-6ralcn8p	206	18	associated	associate	VBN
cord-012418-6ralcn8p	206	19	factor	factor	NN
cord-012418-6ralcn8p	206	20	(	(	-LRB-
cord-012418-6ralcn8p	206	21	PCAF	PCAF	NNP
cord-012418-6ralcn8p	206	22	,	,	,
cord-012418-6ralcn8p	206	23	or	or	CC
cord-012418-6ralcn8p	206	24	KAT2A	KAT2A	NNP
cord-012418-6ralcn8p	206	25	)	)	-RRB-
cord-012418-6ralcn8p	206	26	and	and	CC
cord-012418-6ralcn8p	206	27	general	general	JJ
cord-012418-6ralcn8p	206	28	control	control	NN
cord-012418-6ralcn8p	206	29	nonderepressible-5	nonderepressible-5	NNP
cord-012418-6ralcn8p	207	1	(	(	-LRB-
cord-012418-6ralcn8p	207	2	GCN5	GCN5	NNP
cord-012418-6ralcn8p	207	3	or	or	CC
cord-012418-6ralcn8p	207	4	,	,	,
cord-012418-6ralcn8p	207	5	KAT2B	kat2b	NN
cord-012418-6ralcn8p	207	6	)	)	-RRB-
cord-012418-6ralcn8p	207	7	to	to	IN
cord-012418-6ralcn8p	207	8	the	the	DT
cord-012418-6ralcn8p	207	9	promoter	promoter	NN
cord-012418-6ralcn8p	207	10	and	and	CC
cord-012418-6ralcn8p	207	11	induces	induce	VBZ
cord-012418-6ralcn8p	207	12	the	the	DT
cord-012418-6ralcn8p	207	13	remodelling	remodelling	NN
cord-012418-6ralcn8p	207	14	,	,	,
cord-012418-6ralcn8p	207	15	starting	start	VBG
cord-012418-6ralcn8p	207	16	with	with	IN
cord-012418-6ralcn8p	207	17	GCN5-mediated	gcn5-mediated	JJ
cord-012418-6ralcn8p	207	18	acetylation	acetylation	NN
cord-012418-6ralcn8p	207	19	of	of	IN
cord-012418-6ralcn8p	207	20	nucleosomes	nucleosome	NNS
cord-012418-6ralcn8p	207	21	and	and	CC
cord-012418-6ralcn8p	207	22	HMG	HMG	NNP
cord-012418-6ralcn8p	207	23	I(Y	I(Y	NNP
cord-012418-6ralcn8p	207	24	)	)	-RRB-
cord-012418-6ralcn8p	207	25	in	in	IN
cord-012418-6ralcn8p	207	26	its	-PRON-	PRP$
cord-012418-6ralcn8p	207	27	vicinity	vicinity	NN
cord-012418-6ralcn8p	207	28	[	[	-LRB-
cord-012418-6ralcn8p	207	29	70	70	CD
cord-012418-6ralcn8p	207	30	,	,	,
cord-012418-6ralcn8p	207	31	71	71	CD
cord-012418-6ralcn8p	207	32	,	,	,
cord-012418-6ralcn8p	207	33	103	103	CD
cord-012418-6ralcn8p	207	34	]	]	-RRB-
cord-012418-6ralcn8p	207	35	.	.	.
cord-012418-6ralcn8p	208	1	Acetylation	Acetylation	NNP
cord-012418-6ralcn8p	208	2	of	of	IN
cord-012418-6ralcn8p	208	3	HMG	HMG	NNP
cord-012418-6ralcn8p	208	4	I(Y	I(Y	NNP
cord-012418-6ralcn8p	208	5	)	)	-RRB-
cord-012418-6ralcn8p	208	6	at	at	IN
cord-012418-6ralcn8p	208	7	K71	K71	NNP
cord-012418-6ralcn8p	208	8	by	by	IN
cord-012418-6ralcn8p	208	9	GCN5	GCN5	NNP
cord-012418-6ralcn8p	208	10	strengthens	strengthen	VBZ
cord-012418-6ralcn8p	208	11	the	the	DT
cord-012418-6ralcn8p	208	12	association	association	NN
cord-012418-6ralcn8p	208	13	of	of	IN
cord-012418-6ralcn8p	208	14	NF	NF	NNP
cord-012418-6ralcn8p	208	15	-	-	HYPH
cord-012418-6ralcn8p	208	16	κB	κB	NNP
cord-012418-6ralcn8p	208	17	and	and	CC
cord-012418-6ralcn8p	208	18	thereby	thereby	RB
cord-012418-6ralcn8p	208	19	further	further	RB
cord-012418-6ralcn8p	208	20	stabilises	stabilise	VBZ
cord-012418-6ralcn8p	208	21	the	the	DT
cord-012418-6ralcn8p	208	22	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	208	23	[	[	-LRB-
cord-012418-6ralcn8p	208	24	70	70	CD
cord-012418-6ralcn8p	208	25	,	,	,
cord-012418-6ralcn8p	208	26	71	71	CD
cord-012418-6ralcn8p	208	27	]	]	-RRB-
cord-012418-6ralcn8p	208	28	.	.	.
cord-012418-6ralcn8p	209	1	Next	next	RB
cord-012418-6ralcn8p	209	2	,	,	,
cord-012418-6ralcn8p	209	3	the	the	DT
cord-012418-6ralcn8p	209	4	modification	modification	NN
cord-012418-6ralcn8p	209	5	of	of	IN
cord-012418-6ralcn8p	209	6	the	the	DT
cord-012418-6ralcn8p	209	7	histone	histone	NN
cord-012418-6ralcn8p	209	8	tails	tail	NNS
cord-012418-6ralcn8p	209	9	of	of	IN
cord-012418-6ralcn8p	209	10	nucleosomes	nucleosome	NNS
cord-012418-6ralcn8p	209	11	at	at	IN
cord-012418-6ralcn8p	209	12	H3	H3	NNP
cord-012418-6ralcn8p	209	13	and	and	CC
cord-012418-6ralcn8p	209	14	H4	H4	NNP
cord-012418-6ralcn8p	209	15	promotes	promote	VBZ
cord-012418-6ralcn8p	209	16	recruitment	recruitment	NN
cord-012418-6ralcn8p	209	17	of	of	IN
cord-012418-6ralcn8p	209	18	the	the	DT
cord-012418-6ralcn8p	209	19	chromatin	chromatin	NN
cord-012418-6ralcn8p	209	20	remodelling	remodelle	VBG
cord-012418-6ralcn8p	209	21	BRG1-or	BRG1-or	NNP
cord-012418-6ralcn8p	209	22	BRM	BRM	NNP
cord-012418-6ralcn8p	209	23	-	-	HYPH
cord-012418-6ralcn8p	209	24	associated	associate	VBN
cord-012418-6ralcn8p	209	25	factor	factor	NN
cord-012418-6ralcn8p	209	26	(	(	-LRB-
cord-012418-6ralcn8p	209	27	BAF	BAF	NNP
cord-012418-6ralcn8p	209	28	)	)	-RRB-
cord-012418-6ralcn8p	209	29	complex	complex	NN
cord-012418-6ralcn8p	209	30	of	of	IN
cord-012418-6ralcn8p	209	31	the	the	DT
cord-012418-6ralcn8p	209	32	SWI	SWI	NNP
cord-012418-6ralcn8p	209	33	/	/	SYM
cord-012418-6ralcn8p	209	34	SFN	SFN	NNP
cord-012418-6ralcn8p	209	35	family	family	NN
cord-012418-6ralcn8p	209	36	[	[	-LRB-
cord-012418-6ralcn8p	209	37	71	71	CD
cord-012418-6ralcn8p	209	38	,	,	,
cord-012418-6ralcn8p	209	39	87	87	CD
cord-012418-6ralcn8p	209	40	,	,	,
cord-012418-6ralcn8p	209	41	90	90	CD
cord-012418-6ralcn8p	209	42	,	,	,
cord-012418-6ralcn8p	209	43	102	102	CD
cord-012418-6ralcn8p	209	44	,	,	,
cord-012418-6ralcn8p	209	45	103	103	CD
cord-012418-6ralcn8p	209	46	]	]	-RRB-
cord-012418-6ralcn8p	209	47	.	.	.
cord-012418-6ralcn8p	210	1	In	in	IN
cord-012418-6ralcn8p	210	2	parallel	parallel	JJ
cord-012418-6ralcn8p	210	3	,	,	,
cord-012418-6ralcn8p	210	4	general	general	JJ
cord-012418-6ralcn8p	210	5	eukaryotic	eukaryotic	JJ
cord-012418-6ralcn8p	210	6	transcription	transcription	NN
cord-012418-6ralcn8p	210	7	factors	factor	NNS
cord-012418-6ralcn8p	210	8	(	(	-LRB-
cord-012418-6ralcn8p	210	9	TFs	tf	NNS
cord-012418-6ralcn8p	210	10	)	)	-RRB-
cord-012418-6ralcn8p	210	11	TFIIA	TFIIA	NNP
cord-012418-6ralcn8p	210	12	,	,	,
cord-012418-6ralcn8p	210	13	TFIIB	TFIIB	NNP
cord-012418-6ralcn8p	210	14	,	,	,
cord-012418-6ralcn8p	210	15	TFIIE	TFIIE	NNP
cord-012418-6ralcn8p	210	16	,	,	,
cord-012418-6ralcn8p	210	17	TFIIH	TFIIH	NNP
cord-012418-6ralcn8p	210	18	,	,	,
cord-012418-6ralcn8p	210	19	TFIIF	TFIIF	NNP
cord-012418-6ralcn8p	210	20	and	and	CC
cord-012418-6ralcn8p	210	21	upstream	upstream	JJ
cord-012418-6ralcn8p	210	22	stimulatory	stimulatory	JJ
cord-012418-6ralcn8p	210	23	activity	activity	NN
cord-012418-6ralcn8p	210	24	(	(	-LRB-
cord-012418-6ralcn8p	210	25	USA	USA	NNP
cord-012418-6ralcn8p	210	26	)	)	-RRB-
cord-012418-6ralcn8p	210	27	cofactors	cofactor	NNS
cord-012418-6ralcn8p	210	28	assemble	assemble	VBP
cord-012418-6ralcn8p	210	29	at	at	IN
cord-012418-6ralcn8p	210	30	the	the	DT
cord-012418-6ralcn8p	210	31	promoter	promoter	NN
cord-012418-6ralcn8p	210	32	along	along	IN
cord-012418-6ralcn8p	210	33	with	with	IN
cord-012418-6ralcn8p	210	34	the	the	DT
cord-012418-6ralcn8p	210	35	RNA	RNA	NNP
cord-012418-6ralcn8p	210	36	polymerase	polymerase	NN
cord-012418-6ralcn8p	210	37	II	II	NNP
cord-012418-6ralcn8p	210	38	(	(	-LRB-
cord-012418-6ralcn8p	210	39	RNAP	RNAP	NNP
cord-012418-6ralcn8p	210	40	II	II	NNP
cord-012418-6ralcn8p	210	41	)	)	-RRB-
cord-012418-6ralcn8p	210	42	holoenzyme	holoenzyme	NNP
cord-012418-6ralcn8p	210	43	[	[	-LRB-
cord-012418-6ralcn8p	210	44	71	71	CD
cord-012418-6ralcn8p	210	45	,	,	,
cord-012418-6ralcn8p	210	46	87	87	CD
cord-012418-6ralcn8p	210	47	,	,	,
cord-012418-6ralcn8p	210	48	101	101	CD
cord-012418-6ralcn8p	210	49	]	]	-RRB-
cord-012418-6ralcn8p	210	50	.	.	.
cord-012418-6ralcn8p	211	1	Stimulated	stimulate	VBN
cord-012418-6ralcn8p	211	2	by	by	IN
cord-012418-6ralcn8p	211	3	the	the	DT
cord-012418-6ralcn8p	211	4	environment	environment	NN
cord-012418-6ralcn8p	211	5	rich	rich	JJ
cord-012418-6ralcn8p	211	6	in	in	IN
cord-012418-6ralcn8p	211	7	acetylated	acetylated	JJ
cord-012418-6ralcn8p	211	8	histones	histone	NNS
cord-012418-6ralcn8p	211	9	,	,	,
cord-012418-6ralcn8p	211	10	the	the	DT
cord-012418-6ralcn8p	211	11	ATPase	ATPase	NNP
cord-012418-6ralcn8p	211	12	Brahma	Brahma	NNP
cord-012418-6ralcn8p	211	13	-	-	HYPH
cord-012418-6ralcn8p	211	14	related	relate	VBN
cord-012418-6ralcn8p	211	15	gene	gene	NN
cord-012418-6ralcn8p	211	16	1	1	CD
cord-012418-6ralcn8p	211	17	(	(	-LRB-
cord-012418-6ralcn8p	211	18	BRG1	BRG1	NNP
cord-012418-6ralcn8p	211	19	or	or	CC
cord-012418-6ralcn8p	211	20	SMARCA4	SMARCA4	NNS
cord-012418-6ralcn8p	211	21	)	)	-RRB-
cord-012418-6ralcn8p	211	22	of	of	IN
cord-012418-6ralcn8p	211	23	the	the	DT
cord-012418-6ralcn8p	211	24	BAF	BAF	NNP
cord-012418-6ralcn8p	211	25	complex	complex	NN
cord-012418-6ralcn8p	211	26	induces	induce	VBZ
cord-012418-6ralcn8p	211	27	a	a	DT
cord-012418-6ralcn8p	211	28	conformational	conformational	JJ
cord-012418-6ralcn8p	211	29	change	change	NN
cord-012418-6ralcn8p	211	30	of	of	IN
cord-012418-6ralcn8p	211	31	the	the	DT
cord-012418-6ralcn8p	211	32	nucleosome	nucleosome	NN
cord-012418-6ralcn8p	211	33	at	at	IN
cord-012418-6ralcn8p	211	34	the	the	DT
cord-012418-6ralcn8p	211	35	TSS	TSS	NNP
cord-012418-6ralcn8p	211	36	[	[	-LRB-
cord-012418-6ralcn8p	211	37	71	71	CD
cord-012418-6ralcn8p	211	38	,	,	,
cord-012418-6ralcn8p	211	39	104	104	CD
cord-012418-6ralcn8p	211	40	]	]	-RRB-
cord-012418-6ralcn8p	211	41	.	.	.
cord-012418-6ralcn8p	212	1	Now	now	RB
cord-012418-6ralcn8p	212	2	,	,	,
cord-012418-6ralcn8p	212	3	the	the	DT
cord-012418-6ralcn8p	212	4	TATA	TATA	NNP
cord-012418-6ralcn8p	212	5	box	box	NN
cord-012418-6ralcn8p	212	6	at	at	IN
cord-012418-6ralcn8p	212	7	the	the	DT
cord-012418-6ralcn8p	212	8	TSS	TSS	NNP
cord-012418-6ralcn8p	212	9	is	be	VBZ
cord-012418-6ralcn8p	212	10	available	available	JJ
cord-012418-6ralcn8p	212	11	for	for	IN
cord-012418-6ralcn8p	212	12	binding	bind	VBG
cord-012418-6ralcn8p	212	13	by	by	IN
cord-012418-6ralcn8p	212	14	the	the	DT
cord-012418-6ralcn8p	212	15	TATA	TATA	NNP
cord-012418-6ralcn8p	212	16	box	box	NN
cord-012418-6ralcn8p	212	17	-	-	HYPH
cord-012418-6ralcn8p	212	18	binding	bind	VBG
cord-012418-6ralcn8p	212	19	protein	protein	NN
cord-012418-6ralcn8p	212	20	(	(	-LRB-
cord-012418-6ralcn8p	212	21	TBP	TBP	NNP
cord-012418-6ralcn8p	212	22	)	)	-RRB-
cord-012418-6ralcn8p	212	23	and	and	CC
cord-012418-6ralcn8p	212	24	allows	allow	VBZ
cord-012418-6ralcn8p	212	25	association	association	NN
cord-012418-6ralcn8p	212	26	of	of	IN
cord-012418-6ralcn8p	212	27	the	the	DT
cord-012418-6ralcn8p	212	28	TFIID	TFIID	NNP
cord-012418-6ralcn8p	212	29	complex	complex	NN
cord-012418-6ralcn8p	212	30	[	[	-LRB-
cord-012418-6ralcn8p	212	31	71	71	CD
cord-012418-6ralcn8p	212	32	,	,	,
cord-012418-6ralcn8p	212	33	103	103	CD
cord-012418-6ralcn8p	212	34	]	]	-RRB-
cord-012418-6ralcn8p	212	35	.	.	.
cord-012418-6ralcn8p	213	1	Notably	notably	RB
cord-012418-6ralcn8p	213	2	,	,	,
cord-012418-6ralcn8p	213	3	TFIID	TFIID	NNP
cord-012418-6ralcn8p	213	4	binds	bind	VBZ
cord-012418-6ralcn8p	213	5	here	here	RB
cord-012418-6ralcn8p	213	6	after	after	IN
cord-012418-6ralcn8p	213	7	the	the	DT
cord-012418-6ralcn8p	213	8	RNAP	RNAP	NNP
cord-012418-6ralcn8p	213	9	II	II	NNP
cord-012418-6ralcn8p	213	10	complex	complex	NN
cord-012418-6ralcn8p	213	11	,	,	,
cord-012418-6ralcn8p	213	12	as	as	IN
cord-012418-6ralcn8p	213	13	opposed	oppose	VBN
cord-012418-6ralcn8p	213	14	to	to	IN
cord-012418-6ralcn8p	213	15	the	the	DT
cord-012418-6ralcn8p	213	16	classical	classical	JJ
cord-012418-6ralcn8p	213	17	sequence	sequence	NN
cord-012418-6ralcn8p	213	18	of	of	IN
cord-012418-6ralcn8p	213	19	events	event	NNS
cord-012418-6ralcn8p	213	20	in	in	IN
cord-012418-6ralcn8p	213	21	assembly	assembly	NN
cord-012418-6ralcn8p	213	22	of	of	IN
cord-012418-6ralcn8p	213	23	the	the	DT
cord-012418-6ralcn8p	213	24	pre	pre	JJ
cord-012418-6ralcn8p	213	25	-	-	NN
cord-012418-6ralcn8p	213	26	initiation	initiation	JJ
cord-012418-6ralcn8p	213	27	complex	complex	NN
cord-012418-6ralcn8p	213	28	[	[	-LRB-
cord-012418-6ralcn8p	213	29	105	105	CD
cord-012418-6ralcn8p	213	30	]	]	-RRB-
cord-012418-6ralcn8p	213	31	.	.	.
cord-012418-6ralcn8p	214	1	Association	Association	NNP
cord-012418-6ralcn8p	214	2	of	of	IN
cord-012418-6ralcn8p	214	3	TFIID	TFIID	NNP
cord-012418-6ralcn8p	214	4	induces	induce	VBZ
cord-012418-6ralcn8p	214	5	a	a	DT
cord-012418-6ralcn8p	214	6	bend	bend	NN
cord-012418-6ralcn8p	214	7	of	of	IN
cord-012418-6ralcn8p	214	8	the	the	DT
cord-012418-6ralcn8p	214	9	DNA	dna	NN
cord-012418-6ralcn8p	214	10	helix	helix	NN
cord-012418-6ralcn8p	214	11	so	so	IN
cord-012418-6ralcn8p	214	12	that	that	IN
cord-012418-6ralcn8p	214	13	the	the	DT
cord-012418-6ralcn8p	214	14	nucleosome	nucleosome	NN
cord-012418-6ralcn8p	214	15	covering	cover	VBG
cord-012418-6ralcn8p	214	16	the	the	DT
cord-012418-6ralcn8p	214	17	TATA	TATA	NNP
cord-012418-6ralcn8p	214	18	box	box	NN
cord-012418-6ralcn8p	214	19	slides	slide	VBZ
cord-012418-6ralcn8p	214	20	36	36	CD
cord-012418-6ralcn8p	214	21	bp	bp	NNP
cord-012418-6ralcn8p	214	22	downstream	downstream	NN
cord-012418-6ralcn8p	214	23	of	of	IN
cord-012418-6ralcn8p	214	24	its	-PRON-	PRP$
cord-012418-6ralcn8p	214	25	latent	latent	JJ
cord-012418-6ralcn8p	214	26	position	position	NN
cord-012418-6ralcn8p	214	27	[	[	-LRB-
cord-012418-6ralcn8p	214	28	73	73	CD
cord-012418-6ralcn8p	214	29	,	,	,
cord-012418-6ralcn8p	214	30	106	106	CD
cord-012418-6ralcn8p	214	31	]	]	-RRB-
cord-012418-6ralcn8p	214	32	.	.	.
cord-012418-6ralcn8p	215	1	With	with	IN
cord-012418-6ralcn8p	215	2	this	this	DT
cord-012418-6ralcn8p	215	3	,	,	,
cord-012418-6ralcn8p	215	4	the	the	DT
cord-012418-6ralcn8p	215	5	arrangement	arrangement	NN
cord-012418-6ralcn8p	215	6	of	of	IN
cord-012418-6ralcn8p	215	7	the	the	DT
cord-012418-6ralcn8p	215	8	pre	pre	JJ
cord-012418-6ralcn8p	215	9	-	-	NN
cord-012418-6ralcn8p	215	10	initiation	initiation	JJ
cord-012418-6ralcn8p	215	11	complex	complex	NN
cord-012418-6ralcn8p	215	12	can	can	MD
cord-012418-6ralcn8p	215	13	be	be	VB
cord-012418-6ralcn8p	215	14	completed	complete	VBN
cord-012418-6ralcn8p	215	15	,	,	,
cord-012418-6ralcn8p	215	16	and	and	CC
cord-012418-6ralcn8p	215	17	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	215	18	transcription	transcription	NN
cord-012418-6ralcn8p	215	19	can	can	MD
cord-012418-6ralcn8p	215	20	begin	begin	VB
cord-012418-6ralcn8p	215	21	[	[	-LRB-
cord-012418-6ralcn8p	215	22	17	17	CD
cord-012418-6ralcn8p	215	23	,	,	,
cord-012418-6ralcn8p	215	24	107	107	CD
cord-012418-6ralcn8p	215	25	]	]	-RRB-
cord-012418-6ralcn8p	215	26	.	.	.
cord-012418-6ralcn8p	216	1	Notably	notably	RB
cord-012418-6ralcn8p	216	2	,	,	,
cord-012418-6ralcn8p	216	3	while	while	IN
cord-012418-6ralcn8p	216	4	the	the	DT
cord-012418-6ralcn8p	216	5	rapid	rapid	JJ
cord-012418-6ralcn8p	216	6	induction	induction	NN
cord-012418-6ralcn8p	216	7	of	of	IN
cord-012418-6ralcn8p	216	8	the	the	DT
cord-012418-6ralcn8p	216	9	type	type	NN
cord-012418-6ralcn8p	216	10	I	-PRON-	PRP
cord-012418-6ralcn8p	216	11	IFN	IFN	NNP
cord-012418-6ralcn8p	216	12	response	response	NN
cord-012418-6ralcn8p	216	13	is	be	VBZ
cord-012418-6ralcn8p	216	14	crucial	crucial	JJ
cord-012418-6ralcn8p	216	15	for	for	IN
cord-012418-6ralcn8p	216	16	the	the	DT
cord-012418-6ralcn8p	216	17	host	host	NN
cord-012418-6ralcn8p	216	18	defence	defence	NN
cord-012418-6ralcn8p	216	19	,	,	,
cord-012418-6ralcn8p	216	20	the	the	DT
cord-012418-6ralcn8p	216	21	first	first	JJ
cord-012418-6ralcn8p	216	22	round	round	NN
cord-012418-6ralcn8p	216	23	of	of	IN
cord-012418-6ralcn8p	216	24	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	216	25	expression	expression	NN
cord-012418-6ralcn8p	216	26	yields	yield	VBZ
cord-012418-6ralcn8p	216	27	only	only	RB
cord-012418-6ralcn8p	216	28	low	low	JJ
cord-012418-6ralcn8p	216	29	levels	level	NNS
cord-012418-6ralcn8p	216	30	of	of	IN
cord-012418-6ralcn8p	216	31	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	216	32	,	,	,
cord-012418-6ralcn8p	216	33	as	as	IN
cord-012418-6ralcn8p	216	34	discussed	discuss	VBN
cord-012418-6ralcn8p	216	35	by	by	IN
cord-012418-6ralcn8p	216	36	Ford	Ford	NNP
cord-012418-6ralcn8p	216	37	and	and	CC
cord-012418-6ralcn8p	216	38	Thanos	Thanos	NNP
cord-012418-6ralcn8p	216	39	[	[	-LRB-
cord-012418-6ralcn8p	216	40	17	17	CD
cord-012418-6ralcn8p	216	41	]	]	-RRB-
cord-012418-6ralcn8p	216	42	.	.	.
cord-012418-6ralcn8p	217	1	Briefly	briefly	RB
cord-012418-6ralcn8p	217	2	,	,	,
cord-012418-6ralcn8p	217	3	after	after	IN
cord-012418-6ralcn8p	217	4	stimulation	stimulation	NN
cord-012418-6ralcn8p	217	5	of	of	IN
cord-012418-6ralcn8p	217	6	a	a	DT
cord-012418-6ralcn8p	217	7	cell	cell	NN
cord-012418-6ralcn8p	217	8	population	population	NN
cord-012418-6ralcn8p	217	9	,	,	,
cord-012418-6ralcn8p	217	10	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	217	11	is	be	VBZ
cord-012418-6ralcn8p	217	12	initially	initially	RB
cord-012418-6ralcn8p	217	13	expressed	express	VBN
cord-012418-6ralcn8p	217	14	only	only	RB
cord-012418-6ralcn8p	217	15	by	by	IN
cord-012418-6ralcn8p	217	16	a	a	DT
cord-012418-6ralcn8p	217	17	fraction	fraction	NN
cord-012418-6ralcn8p	217	18	of	of	IN
cord-012418-6ralcn8p	217	19	cells	cell	NNS
cord-012418-6ralcn8p	217	20	and	and	CC
cord-012418-6ralcn8p	217	21	from	from	IN
cord-012418-6ralcn8p	217	22	only	only	RB
cord-012418-6ralcn8p	217	23	one	one	CD
cord-012418-6ralcn8p	217	24	allele	allele	NN
cord-012418-6ralcn8p	217	25	due	due	IN
cord-012418-6ralcn8p	217	26	to	to	IN
cord-012418-6ralcn8p	217	27	a	a	DT
cord-012418-6ralcn8p	217	28	stochastic	stochastic	JJ
cord-012418-6ralcn8p	217	29	phenomenon	phenomenon	NN
cord-012418-6ralcn8p	217	30	that	that	WDT
cord-012418-6ralcn8p	217	31	indicates	indicate	VBZ
cord-012418-6ralcn8p	217	32	a	a	DT
cord-012418-6ralcn8p	217	33	limiting	limit	VBG
cord-012418-6ralcn8p	217	34	amount	amount	NN
cord-012418-6ralcn8p	217	35	of	of	IN
cord-012418-6ralcn8p	217	36	required	require	VBN
cord-012418-6ralcn8p	217	37	cellular	cellular	JJ
cord-012418-6ralcn8p	217	38	factors	factor	NNS
cord-012418-6ralcn8p	217	39	[	[	-LRB-
cord-012418-6ralcn8p	217	40	108	108	CD
cord-012418-6ralcn8p	217	41	]	]	-RRB-
cord-012418-6ralcn8p	217	42	[	[	-LRB-
cord-012418-6ralcn8p	217	43	109	109	CD
cord-012418-6ralcn8p	217	44	]	]	-RRB-
cord-012418-6ralcn8p	217	45	[	[	-LRB-
cord-012418-6ralcn8p	217	46	110	110	CD
cord-012418-6ralcn8p	217	47	]	]	-RRB-
cord-012418-6ralcn8p	217	48	.	.	.
cord-012418-6ralcn8p	218	1	The	the	DT
cord-012418-6ralcn8p	218	2	initial	initial	JJ
cord-012418-6ralcn8p	218	3	recruitment	recruitment	NN
cord-012418-6ralcn8p	218	4	of	of	IN
cord-012418-6ralcn8p	218	5	NF	NF	NNP
cord-012418-6ralcn8p	218	6	-	-	HYPH
cord-012418-6ralcn8p	218	7	κB	κB	NNP
cord-012418-6ralcn8p	218	8	to	to	IN
cord-012418-6ralcn8p	218	9	other	other	JJ
cord-012418-6ralcn8p	218	10	loci	locus	NNS
cord-012418-6ralcn8p	218	11	that	that	WDT
cord-012418-6ralcn8p	218	12	collect	collect	VBP
cord-012418-6ralcn8p	218	13	the	the	DT
cord-012418-6ralcn8p	218	14	available	available	JJ
cord-012418-6ralcn8p	218	15	transcription	transcription	NN
cord-012418-6ralcn8p	218	16	factor	factor	NN
cord-012418-6ralcn8p	218	17	and	and	CC
cord-012418-6ralcn8p	218	18	transfer	transfer	VB
cord-012418-6ralcn8p	218	19	it	-PRON-	PRP
cord-012418-6ralcn8p	218	20	to	to	IN
cord-012418-6ralcn8p	218	21	the	the	DT
cord-012418-6ralcn8p	218	22	required	require	VBN
cord-012418-6ralcn8p	218	23	binding	binding	NN
cord-012418-6ralcn8p	218	24	sequence	sequence	NN
cord-012418-6ralcn8p	218	25	highlights	highlight	VBZ
cord-012418-6ralcn8p	218	26	the	the	DT
cord-012418-6ralcn8p	218	27	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	218	28	heterodimer	heterodimer	NN
cord-012418-6ralcn8p	218	29	as	as	IN
cord-012418-6ralcn8p	218	30	the	the	DT
cord-012418-6ralcn8p	218	31	most	most	RBS
cord-012418-6ralcn8p	218	32	limiting	limit	VBG
cord-012418-6ralcn8p	218	33	factor	factor	NN
cord-012418-6ralcn8p	218	34	[	[	-LRB-
cord-012418-6ralcn8p	218	35	83	83	CD
cord-012418-6ralcn8p	218	36	,	,	,
cord-012418-6ralcn8p	218	37	84	84	CD
cord-012418-6ralcn8p	218	38	]	]	-RRB-
cord-012418-6ralcn8p	218	39	.	.	.
cord-012418-6ralcn8p	219	1	The	the	DT
cord-012418-6ralcn8p	219	2	weak	weak	JJ
cord-012418-6ralcn8p	219	3	initial	initial	JJ
cord-012418-6ralcn8p	219	4	signal	signal	NN
cord-012418-6ralcn8p	219	5	of	of	IN
cord-012418-6ralcn8p	219	6	secreted	secrete	VBN
cord-012418-6ralcn8p	219	7	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	219	8	induces	induce	VBZ
cord-012418-6ralcn8p	219	9	high	high	JJ
cord-012418-6ralcn8p	219	10	-	-	HYPH
cord-012418-6ralcn8p	219	11	level	level	NN
cord-012418-6ralcn8p	219	12	expression	expression	NN
cord-012418-6ralcn8p	219	13	of	of	IN
cord-012418-6ralcn8p	219	14	IRF7	IRF7	NNP
cord-012418-6ralcn8p	219	15	,	,	,
cord-012418-6ralcn8p	219	16	and	and	CC
cord-012418-6ralcn8p	219	17	newly	newly	RB
cord-012418-6ralcn8p	219	18	synthesized	synthesize	VBN
cord-012418-6ralcn8p	219	19	IRF7	IRF7	NNP
cord-012418-6ralcn8p	219	20	promotes	promote	VBZ
cord-012418-6ralcn8p	219	21	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	219	22	assembly	assembly	NN
cord-012418-6ralcn8p	219	23	and	and	CC
cord-012418-6ralcn8p	219	24	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	219	25	transcription	transcription	NN
cord-012418-6ralcn8p	219	26	from	from	IN
cord-012418-6ralcn8p	219	27	the	the	DT
cord-012418-6ralcn8p	219	28	remaining	remain	VBG
cord-012418-6ralcn8p	219	29	allele	allele	NN
cord-012418-6ralcn8p	219	30	and	and	CC
cord-012418-6ralcn8p	219	31	in	in	IN
cord-012418-6ralcn8p	219	32	more	more	JJR
cord-012418-6ralcn8p	219	33	cells	cell	NNS
cord-012418-6ralcn8p	219	34	[	[	-LRB-
cord-012418-6ralcn8p	219	35	83	83	CD
cord-012418-6ralcn8p	219	36	]	]	-RRB-
cord-012418-6ralcn8p	219	37	.	.	.
cord-012418-6ralcn8p	220	1	Finally	finally	RB
cord-012418-6ralcn8p	220	2	,	,	,
cord-012418-6ralcn8p	220	3	the	the	DT
cord-012418-6ralcn8p	220	4	weak	weak	JJ
cord-012418-6ralcn8p	220	5	initial	initial	JJ
cord-012418-6ralcn8p	220	6	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	220	7	signal	signal	NN
cord-012418-6ralcn8p	220	8	is	be	VBZ
cord-012418-6ralcn8p	220	9	then	then	RB
cord-012418-6ralcn8p	220	10	amplified	amplify	VBN
cord-012418-6ralcn8p	220	11	to	to	TO
cord-012418-6ralcn8p	220	12	eventually	eventually	RB
cord-012418-6ralcn8p	220	13	induce	induce	VB
cord-012418-6ralcn8p	220	14	the	the	DT
cord-012418-6ralcn8p	220	15	cytokine	cytokine	NN
cord-012418-6ralcn8p	220	16	storm	storm	NN
cord-012418-6ralcn8p	220	17	of	of	IN
cord-012418-6ralcn8p	220	18	the	the	DT
cord-012418-6ralcn8p	220	19	antiviral	antiviral	JJ
cord-012418-6ralcn8p	220	20	response	response	NN
cord-012418-6ralcn8p	220	21	.	.	.
cord-012418-6ralcn8p	221	1	The	the	DT
cord-012418-6ralcn8p	221	2	expression	expression	NN
cord-012418-6ralcn8p	221	3	of	of	IN
cord-012418-6ralcn8p	221	4	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	221	5	is	be	VBZ
cord-012418-6ralcn8p	221	6	,	,	,
cord-012418-6ralcn8p	221	7	at	at	IN
cord-012418-6ralcn8p	221	8	least	least	JJS
cord-012418-6ralcn8p	221	9	in	in	IN
cord-012418-6ralcn8p	221	10	murine	murine	JJ
cord-012418-6ralcn8p	221	11	cells	cell	NNS
cord-012418-6ralcn8p	221	12	,	,	,
cord-012418-6ralcn8p	221	13	tightly	tightly	RB
cord-012418-6ralcn8p	221	14	regulated	regulate	VBN
cord-012418-6ralcn8p	221	15	by	by	IN
cord-012418-6ralcn8p	221	16	different	different	JJ
cord-012418-6ralcn8p	221	17	forms	form	NNS
cord-012418-6ralcn8p	221	18	of	of	IN
cord-012418-6ralcn8p	221	19	NF	nf	NN
cord-012418-6ralcn8p	221	20	-	-	HYPH
cord-012418-6ralcn8p	221	21	κB	κB	NNP
cord-012418-6ralcn8p	221	22	dimers	dimer	NNS
cord-012418-6ralcn8p	221	23	in	in	IN
cord-012418-6ralcn8p	221	24	the	the	DT
cord-012418-6ralcn8p	221	25	initial	initial	JJ
cord-012418-6ralcn8p	221	26	response	response	NN
cord-012418-6ralcn8p	221	27	to	to	IN
cord-012418-6ralcn8p	221	28	infection	infection	NN
cord-012418-6ralcn8p	221	29	,	,	,
cord-012418-6ralcn8p	221	30	as	as	IN
cord-012418-6ralcn8p	221	31	reviewed	review	VBN
cord-012418-6ralcn8p	221	32	by	by	IN
cord-012418-6ralcn8p	221	33	Balachandran	Balachandran	NNP
cord-012418-6ralcn8p	221	34	and	and	CC
cord-012418-6ralcn8p	221	35	Beg	beg	VBP
cord-012418-6ralcn8p	221	36	[	[	-LRB-
cord-012418-6ralcn8p	221	37	111	111	CD
cord-012418-6ralcn8p	221	38	]	]	-RRB-
cord-012418-6ralcn8p	221	39	.	.	.
cord-012418-6ralcn8p	222	1	At	at	IN
cord-012418-6ralcn8p	222	2	resting	rest	VBG
cord-012418-6ralcn8p	222	3	conditions	condition	NNS
cord-012418-6ralcn8p	222	4	,	,	,
cord-012418-6ralcn8p	222	5	p50	p50	NNP
cord-012418-6ralcn8p	222	6	homodimers	homodimer	NNS
cord-012418-6ralcn8p	222	7	associate	associate	VBP
cord-012418-6ralcn8p	222	8	with	with	IN
cord-012418-6ralcn8p	222	9	the	the	DT
cord-012418-6ralcn8p	222	10	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	222	11	promoter	promoter	NN
cord-012418-6ralcn8p	222	12	region	region	NN
cord-012418-6ralcn8p	222	13	and	and	CC
cord-012418-6ralcn8p	222	14	repress	repress	VB
cord-012418-6ralcn8p	222	15	basal	basal	NN
cord-012418-6ralcn8p	222	16	transcription	transcription	NN
cord-012418-6ralcn8p	222	17	in	in	IN
cord-012418-6ralcn8p	222	18	the	the	DT
cord-012418-6ralcn8p	222	19	absence	absence	NN
cord-012418-6ralcn8p	222	20	of	of	IN
cord-012418-6ralcn8p	222	21	appropriate	appropriate	JJ
cord-012418-6ralcn8p	222	22	stimulation	stimulation	NN
cord-012418-6ralcn8p	222	23	[	[	-LRB-
cord-012418-6ralcn8p	222	24	66	66	CD
cord-012418-6ralcn8p	222	25	,	,	,
cord-012418-6ralcn8p	222	26	112	112	CD
cord-012418-6ralcn8p	222	27	,	,	,
cord-012418-6ralcn8p	222	28	113	113	CD
cord-012418-6ralcn8p	222	29	]	]	-RRB-
cord-012418-6ralcn8p	222	30	.	.	.
cord-012418-6ralcn8p	223	1	In	in	IN
cord-012418-6ralcn8p	223	2	addition	addition	NN
cord-012418-6ralcn8p	223	3	,	,	,
cord-012418-6ralcn8p	223	4	a	a	DT
cord-012418-6ralcn8p	223	5	binding	binding	JJ
cord-012418-6ralcn8p	223	6	site	site	NN
cord-012418-6ralcn8p	223	7	for	for	IN
cord-012418-6ralcn8p	223	8	NF	nf	NN
cord-012418-6ralcn8p	223	9	-	-	HYPH
cord-012418-6ralcn8p	223	10	κB	κb	CD
cord-012418-6ralcn8p	223	11	regulatory	regulatory	JJ
cord-012418-6ralcn8p	223	12	factor	factor	NN
cord-012418-6ralcn8p	223	13	(	(	-LRB-
cord-012418-6ralcn8p	223	14	NRF	NRF	NNP
cord-012418-6ralcn8p	223	15	)	)	-RRB-
cord-012418-6ralcn8p	223	16	overlaps	overlap	VBZ
cord-012418-6ralcn8p	223	17	the	the	DT
cord-012418-6ralcn8p	223	18	NF	nf	NN
cord-012418-6ralcn8p	223	19	-	-	HYPH
cord-012418-6ralcn8p	223	20	κB	κb	CD
cord-012418-6ralcn8p	223	21	binding	bind	VBG
cord-012418-6ralcn8p	223	22	element	element	NN
cord-012418-6ralcn8p	223	23	in	in	IN
cord-012418-6ralcn8p	223	24	PRDII	PRDII	NNP
cord-012418-6ralcn8p	223	25	and	and	CC
cord-012418-6ralcn8p	223	26	negatively	negatively	RB
cord-012418-6ralcn8p	223	27	affects	affect	VBZ
cord-012418-6ralcn8p	223	28	basal	basal	NN
cord-012418-6ralcn8p	223	29	transcription	transcription	NN
cord-012418-6ralcn8p	223	30	[	[	-LRB-
cord-012418-6ralcn8p	223	31	114	114	CD
cord-012418-6ralcn8p	223	32	,	,	,
cord-012418-6ralcn8p	223	33	115	115	CD
cord-012418-6ralcn8p	223	34	]	]	-RRB-
cord-012418-6ralcn8p	223	35	.	.	.
cord-012418-6ralcn8p	224	1	In	in	IN
cord-012418-6ralcn8p	224	2	line	line	NN
cord-012418-6ralcn8p	224	3	with	with	IN
cord-012418-6ralcn8p	224	4	a	a	DT
cord-012418-6ralcn8p	224	5	primary	primary	JJ
cord-012418-6ralcn8p	224	6	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	224	7	effect	effect	NN
cord-012418-6ralcn8p	224	8	,	,	,
cord-012418-6ralcn8p	224	9	knockout	knockout	NN
cord-012418-6ralcn8p	224	10	of	of	IN
cord-012418-6ralcn8p	224	11	murine	murine	JJ
cord-012418-6ralcn8p	224	12	p50	p50	NN
cord-012418-6ralcn8p	224	13	does	do	VBZ
cord-012418-6ralcn8p	224	14	not	not	RB
cord-012418-6ralcn8p	224	15	affect	affect	VB
cord-012418-6ralcn8p	224	16	induction	induction	NN
cord-012418-6ralcn8p	224	17	of	of	IN
cord-012418-6ralcn8p	224	18	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	224	19	expression	expression	NN
cord-012418-6ralcn8p	224	20	after	after	IN
cord-012418-6ralcn8p	224	21	virus	virus	NN
cord-012418-6ralcn8p	224	22	infection	infection	NN
cord-012418-6ralcn8p	224	23	[	[	-LRB-
cord-012418-6ralcn8p	224	24	116	116	CD
cord-012418-6ralcn8p	224	25	]	]	-RRB-
cord-012418-6ralcn8p	224	26	.	.	.
cord-012418-6ralcn8p	225	1	However	however	RB
cord-012418-6ralcn8p	225	2	,	,	,
cord-012418-6ralcn8p	225	3	the	the	DT
cord-012418-6ralcn8p	225	4	p50-imposed	p50-imposed	JJ
cord-012418-6ralcn8p	225	5	down	down	NN
cord-012418-6ralcn8p	225	6	-	-	HYPH
cord-012418-6ralcn8p	225	7	regulation	regulation	NN
cord-012418-6ralcn8p	225	8	in	in	IN
cord-012418-6ralcn8p	225	9	resting	rest	VBG
cord-012418-6ralcn8p	225	10	cells	cell	NNS
cord-012418-6ralcn8p	225	11	is	be	VBZ
cord-012418-6ralcn8p	225	12	competed	compete	VBN
cord-012418-6ralcn8p	225	13	with	with	IN
cord-012418-6ralcn8p	225	14	by	by	IN
cord-012418-6ralcn8p	225	15	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	225	16	dimers	dimer	NNS
cord-012418-6ralcn8p	225	17	that	that	WDT
cord-012418-6ralcn8p	225	18	are	be	VBP
cord-012418-6ralcn8p	225	19	constitutively	constitutively	RB
cord-012418-6ralcn8p	225	20	activated	activate	VBN
cord-012418-6ralcn8p	225	21	by	by	IN
cord-012418-6ralcn8p	225	22	IKKβ	IKKβ	NNS
cord-012418-6ralcn8p	225	23	and	and	CC
cord-012418-6ralcn8p	225	24	cycle	cycle	NN
cord-012418-6ralcn8p	225	25	between	between	IN
cord-012418-6ralcn8p	225	26	the	the	DT
cord-012418-6ralcn8p	225	27	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	225	28	and	and	CC
cord-012418-6ralcn8p	225	29	nucleus	nucleus	NN
cord-012418-6ralcn8p	225	30	[	[	-LRB-
cord-012418-6ralcn8p	225	31	117	117	CD
cord-012418-6ralcn8p	225	32	]	]	-RRB-
cord-012418-6ralcn8p	225	33	.	.	.
cord-012418-6ralcn8p	226	1	This	this	DT
cord-012418-6ralcn8p	226	2	low	low	JJ
cord-012418-6ralcn8p	226	3	level	level	NN
cord-012418-6ralcn8p	226	4	activity	activity	NN
cord-012418-6ralcn8p	226	5	of	of	IN
cord-012418-6ralcn8p	226	6	p65	p65	NN
cord-012418-6ralcn8p	226	7	supports	support	VBZ
cord-012418-6ralcn8p	226	8	a	a	DT
cord-012418-6ralcn8p	226	9	basal	basal	NN
cord-012418-6ralcn8p	226	10	level	level	NN
cord-012418-6ralcn8p	226	11	of	of	IN
cord-012418-6ralcn8p	226	12	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	226	13	expression	expression	NN
cord-012418-6ralcn8p	226	14	that	that	WDT
cord-012418-6ralcn8p	226	15	ensures	ensure	VBZ
cord-012418-6ralcn8p	226	16	rapid	rapid	JJ
cord-012418-6ralcn8p	226	17	and	and	CC
cord-012418-6ralcn8p	226	18	robust	robust	JJ
cord-012418-6ralcn8p	226	19	responsiveness	responsiveness	NN
cord-012418-6ralcn8p	226	20	on	on	IN
cord-012418-6ralcn8p	226	21	demand	demand	NN
cord-012418-6ralcn8p	226	22	,	,	,
cord-012418-6ralcn8p	226	23	while	while	IN
cord-012418-6ralcn8p	226	24	the	the	DT
cord-012418-6ralcn8p	226	25	negative	negative	JJ
cord-012418-6ralcn8p	226	26	regulation	regulation	NN
cord-012418-6ralcn8p	226	27	by	by	IN
cord-012418-6ralcn8p	226	28	p50	p50	NN
cord-012418-6ralcn8p	226	29	ensures	ensure	VBZ
cord-012418-6ralcn8p	226	30	specificity	specificity	NN
cord-012418-6ralcn8p	226	31	[	[	-LRB-
cord-012418-6ralcn8p	226	32	113	113	CD
cord-012418-6ralcn8p	226	33	]	]	-RRB-
cord-012418-6ralcn8p	226	34	.	.	.
cord-012418-6ralcn8p	227	1	After	after	IN
cord-012418-6ralcn8p	227	2	stimulation	stimulation	NN
cord-012418-6ralcn8p	227	3	,	,	,
cord-012418-6ralcn8p	227	4	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	227	5	is	be	VBZ
cord-012418-6ralcn8p	227	6	required	require	VBN
cord-012418-6ralcn8p	227	7	to	to	TO
cord-012418-6ralcn8p	227	8	assist	assist	VB
cord-012418-6ralcn8p	227	9	in	in	IN
cord-012418-6ralcn8p	227	10	the	the	DT
cord-012418-6ralcn8p	227	11	early	early	JJ
cord-012418-6ralcn8p	227	12	recruitment	recruitment	NN
cord-012418-6ralcn8p	227	13	of	of	IN
cord-012418-6ralcn8p	227	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	227	15	together	together	RB
cord-012418-6ralcn8p	227	16	with	with	IN
cord-012418-6ralcn8p	227	17	CBP	CBP	NNP
cord-012418-6ralcn8p	227	18	/	/	SYM
cord-012418-6ralcn8p	227	19	p300	p300	NNP
cord-012418-6ralcn8p	227	20	to	to	TO
cord-012418-6ralcn8p	227	21	support	support	VB
cord-012418-6ralcn8p	227	22	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	227	23	expression	expression	NN
cord-012418-6ralcn8p	227	24	[	[	-LRB-
cord-012418-6ralcn8p	227	25	90	90	CD
cord-012418-6ralcn8p	227	26	,	,	,
cord-012418-6ralcn8p	227	27	113	113	CD
cord-012418-6ralcn8p	227	28	,	,	,
cord-012418-6ralcn8p	227	29	118	118	CD
cord-012418-6ralcn8p	227	30	]	]	-RRB-
cord-012418-6ralcn8p	227	31	.	.	.
cord-012418-6ralcn8p	228	1	Only	only	RB
cord-012418-6ralcn8p	228	2	at	at	IN
cord-012418-6ralcn8p	228	3	high	high	JJ
cord-012418-6ralcn8p	228	4	levels	level	NNS
cord-012418-6ralcn8p	228	5	of	of	IN
cord-012418-6ralcn8p	228	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	228	7	activity	activity	NN
cord-012418-6ralcn8p	228	8	,	,	,
cord-012418-6ralcn8p	228	9	i.e.	i.e.	FW
cord-012418-6ralcn8p	228	10	,	,	,
cord-012418-6ralcn8p	228	11	at	at	IN
cord-012418-6ralcn8p	228	12	the	the	DT
cord-012418-6ralcn8p	228	13	peak	peak	NN
cord-012418-6ralcn8p	228	14	of	of	IN
cord-012418-6ralcn8p	228	15	activity	activity	NN
cord-012418-6ralcn8p	228	16	later	later	RB
cord-012418-6ralcn8p	228	17	in	in	IN
cord-012418-6ralcn8p	228	18	infection	infection	NN
cord-012418-6ralcn8p	228	19	or	or	CC
cord-012418-6ralcn8p	228	20	brought	bring	VBN
cord-012418-6ralcn8p	228	21	about	about	RP
cord-012418-6ralcn8p	228	22	by	by	IN
cord-012418-6ralcn8p	228	23	expression	expression	NN
cord-012418-6ralcn8p	228	24	of	of	IN
cord-012418-6ralcn8p	228	25	the	the	DT
cord-012418-6ralcn8p	228	26	constitutively	constitutively	RB
cord-012418-6ralcn8p	228	27	active	active	JJ
cord-012418-6ralcn8p	228	28	IRF3-S396D	irf3-s396d	NN
cord-012418-6ralcn8p	228	29	,	,	,
cord-012418-6ralcn8p	228	30	p50-p65	p50-p65	NNS
cord-012418-6ralcn8p	228	31	is	be	VBZ
cord-012418-6ralcn8p	228	32	dispensable	dispensable	JJ
cord-012418-6ralcn8p	228	33	for	for	IN
cord-012418-6ralcn8p	228	34	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	228	35	transcription	transcription	NN
cord-012418-6ralcn8p	228	36	[	[	-LRB-
cord-012418-6ralcn8p	228	37	118	118	CD
cord-012418-6ralcn8p	228	38	]	]	-RRB-
cord-012418-6ralcn8p	228	39	.	.	.
cord-012418-6ralcn8p	229	1	Subsequent	subsequent	JJ
cord-012418-6ralcn8p	229	2	to	to	IN
cord-012418-6ralcn8p	229	3	the	the	DT
cord-012418-6ralcn8p	229	4	initial	initial	JJ
cord-012418-6ralcn8p	229	5	recruitment	recruitment	NN
cord-012418-6ralcn8p	229	6	,	,	,
cord-012418-6ralcn8p	229	7	the	the	DT
cord-012418-6ralcn8p	229	8	increasing	increase	VBG
cord-012418-6ralcn8p	229	9	levels	level	NNS
cord-012418-6ralcn8p	229	10	of	of	IN
cord-012418-6ralcn8p	229	11	active	active	JJ
cord-012418-6ralcn8p	229	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	229	13	and	and	CC
cord-012418-6ralcn8p	229	14	IRF7	IRF7	NNP
cord-012418-6ralcn8p	229	15	can	can	MD
cord-012418-6ralcn8p	229	16	fully	fully	RB
cord-012418-6ralcn8p	229	17	assume	assume	VB
cord-012418-6ralcn8p	229	18	the	the	DT
cord-012418-6ralcn8p	229	19	regulation	regulation	NN
cord-012418-6ralcn8p	229	20	of	of	IN
cord-012418-6ralcn8p	229	21	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	229	22	production	production	NN
cord-012418-6ralcn8p	229	23	,	,	,
cord-012418-6ralcn8p	229	24	and	and	CC
cord-012418-6ralcn8p	229	25	NF	nf	NN
cord-012418-6ralcn8p	229	26	-	-	HYPH
cord-012418-6ralcn8p	229	27	κB	κB	NNP
cord-012418-6ralcn8p	229	28	proceeds	proceed	NNS
cord-012418-6ralcn8p	229	29	to	to	TO
cord-012418-6ralcn8p	229	30	regulate	regulate	VB
cord-012418-6ralcn8p	229	31	expression	expression	NN
cord-012418-6ralcn8p	229	32	of	of	IN
cord-012418-6ralcn8p	229	33	pro	pro	JJ
cord-012418-6ralcn8p	229	34	-	-	JJ
cord-012418-6ralcn8p	229	35	inflammatory	inflammatory	JJ
cord-012418-6ralcn8p	229	36	genes	gene	NNS
cord-012418-6ralcn8p	229	37	[	[	-LRB-
cord-012418-6ralcn8p	229	38	118	118	CD
cord-012418-6ralcn8p	229	39	]	]	-RRB-
cord-012418-6ralcn8p	229	40	.	.	.
cord-012418-6ralcn8p	230	1	The	the	DT
cord-012418-6ralcn8p	230	2	p50-p65-mediated	p50-p65-mediated	JJ
cord-012418-6ralcn8p	230	3	basal	basal	JJ
cord-012418-6ralcn8p	230	4	expression	expression	NN
cord-012418-6ralcn8p	230	5	of	of	IN
cord-012418-6ralcn8p	230	6	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	230	7	raises	raise	VBZ
cord-012418-6ralcn8p	230	8	the	the	DT
cord-012418-6ralcn8p	230	9	question	question	NN
cord-012418-6ralcn8p	230	10	how	how	WRB
cord-012418-6ralcn8p	230	11	recruitment	recruitment	NN
cord-012418-6ralcn8p	230	12	of	of	IN
cord-012418-6ralcn8p	230	13	the	the	DT
cord-012418-6ralcn8p	230	14	transcription	transcription	NN
cord-012418-6ralcn8p	230	15	machinery	machinery	NN
cord-012418-6ralcn8p	230	16	is	be	VBZ
cord-012418-6ralcn8p	230	17	achieved	achieve	VBN
cord-012418-6ralcn8p	230	18	at	at	IN
cord-012418-6ralcn8p	230	19	resting	rest	VBG
cord-012418-6ralcn8p	230	20	conditions	condition	NNS
cord-012418-6ralcn8p	230	21	,	,	,
cord-012418-6ralcn8p	230	22	considering	consider	VBG
cord-012418-6ralcn8p	230	23	that	that	IN
cord-012418-6ralcn8p	230	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	230	25	is	be	VBZ
cord-012418-6ralcn8p	230	26	missing	miss	VBG
cord-012418-6ralcn8p	230	27	to	to	TO
cord-012418-6ralcn8p	230	28	participate	participate	VB
cord-012418-6ralcn8p	230	29	in	in	IN
cord-012418-6ralcn8p	230	30	a	a	DT
cord-012418-6ralcn8p	230	31	highly	highly	RB
cord-012418-6ralcn8p	230	32	cooperative	cooperative	JJ
cord-012418-6ralcn8p	230	33	assembly	assembly	NN
cord-012418-6ralcn8p	230	34	as	as	IN
cord-012418-6ralcn8p	230	35	described	describe	VBN
cord-012418-6ralcn8p	230	36	above	above	RB
cord-012418-6ralcn8p	230	37	.	.	.
cord-012418-6ralcn8p	231	1	Moreover	moreover	RB
cord-012418-6ralcn8p	231	2	,	,	,
cord-012418-6ralcn8p	231	3	since	since	IN
cord-012418-6ralcn8p	231	4	the	the	DT
cord-012418-6ralcn8p	231	5	type	type	NN
cord-012418-6ralcn8p	231	6	I	-PRON-	PRP
cord-012418-6ralcn8p	231	7	IFN	IFN	NNP
cord-012418-6ralcn8p	231	8	system	system	NN
cord-012418-6ralcn8p	231	9	is	be	VBZ
cord-012418-6ralcn8p	231	10	not	not	RB
cord-012418-6ralcn8p	231	11	100	100	CD
cord-012418-6ralcn8p	231	12	%	%	NN
cord-012418-6ralcn8p	231	13	conserved	conserve	VBN
cord-012418-6ralcn8p	231	14	between	between	IN
cord-012418-6ralcn8p	231	15	mice	mouse	NNS
cord-012418-6ralcn8p	231	16	and	and	CC
cord-012418-6ralcn8p	231	17	humans	human	NNS
cord-012418-6ralcn8p	231	18	,	,	,
cord-012418-6ralcn8p	231	19	and	and	CC
cord-012418-6ralcn8p	231	20	all	all	DT
cord-012418-6ralcn8p	231	21	of	of	IN
cord-012418-6ralcn8p	231	22	these	these	DT
cord-012418-6ralcn8p	231	23	studies	study	NNS
cord-012418-6ralcn8p	231	24	were	be	VBD
cord-012418-6ralcn8p	231	25	carried	carry	VBN
cord-012418-6ralcn8p	231	26	out	out	RP
cord-012418-6ralcn8p	231	27	in	in	IN
cord-012418-6ralcn8p	231	28	murine	murine	JJ
cord-012418-6ralcn8p	231	29	systems	system	NNS
cord-012418-6ralcn8p	231	30	,	,	,
cord-012418-6ralcn8p	231	31	it	-PRON-	PRP
cord-012418-6ralcn8p	231	32	remains	remain	VBZ
cord-012418-6ralcn8p	231	33	to	to	TO
cord-012418-6ralcn8p	231	34	be	be	VB
cord-012418-6ralcn8p	231	35	confirmed	confirm	VBN
cord-012418-6ralcn8p	231	36	whether	whether	IN
cord-012418-6ralcn8p	231	37	the	the	DT
cord-012418-6ralcn8p	231	38	exact	exact	JJ
cord-012418-6ralcn8p	231	39	same	same	JJ
cord-012418-6ralcn8p	231	40	mode	mode	NN
cord-012418-6ralcn8p	231	41	applies	apply	VBZ
cord-012418-6ralcn8p	231	42	for	for	IN
cord-012418-6ralcn8p	231	43	the	the	DT
cord-012418-6ralcn8p	231	44	participation	participation	NN
cord-012418-6ralcn8p	231	45	of	of	IN
cord-012418-6ralcn8p	231	46	NF	NF	NNP
cord-012418-6ralcn8p	231	47	-	-	HYPH
cord-012418-6ralcn8p	231	48	κB	κB	NNP
cord-012418-6ralcn8p	231	49	in	in	IN
cord-012418-6ralcn8p	231	50	the	the	DT
cord-012418-6ralcn8p	231	51	human	human	JJ
cord-012418-6ralcn8p	231	52	system	system	NN
cord-012418-6ralcn8p	231	53	.	.	.
cord-012418-6ralcn8p	232	1	In	in	IN
cord-012418-6ralcn8p	232	2	addition	addition	NN
cord-012418-6ralcn8p	232	3	to	to	IN
cord-012418-6ralcn8p	232	4	the	the	DT
cord-012418-6ralcn8p	232	5	proximal	proximal	JJ
cord-012418-6ralcn8p	232	6	enhancer	enhancer	NN
cord-012418-6ralcn8p	232	7	,	,	,
cord-012418-6ralcn8p	232	8	DNA	dna	NN
cord-012418-6ralcn8p	232	9	elements	element	NNS
cord-012418-6ralcn8p	232	10	further	further	RB
cord-012418-6ralcn8p	232	11	away	away	RB
cord-012418-6ralcn8p	232	12	from	from	IN
cord-012418-6ralcn8p	232	13	the	the	DT
cord-012418-6ralcn8p	232	14	promoter	promoter	NN
cord-012418-6ralcn8p	232	15	are	be	VBP
cord-012418-6ralcn8p	232	16	involved	involve	VBN
cord-012418-6ralcn8p	232	17	in	in	IN
cord-012418-6ralcn8p	232	18	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	232	19	transcription	transcription	NN
cord-012418-6ralcn8p	232	20	,	,	,
cord-012418-6ralcn8p	232	21	though	though	IN
cord-012418-6ralcn8p	232	22	again	again	RB
cord-012418-6ralcn8p	232	23	,	,	,
cord-012418-6ralcn8p	232	24	most	most	JJS
cord-012418-6ralcn8p	232	25	studies	study	NNS
cord-012418-6ralcn8p	232	26	have	have	VBP
cord-012418-6ralcn8p	232	27	thus	thus	RB
cord-012418-6ralcn8p	232	28	far	far	RB
cord-012418-6ralcn8p	232	29	focused	focused	JJ
cord-012418-6ralcn8p	232	30	on	on	IN
cord-012418-6ralcn8p	232	31	the	the	DT
cord-012418-6ralcn8p	232	32	murine	murine	JJ
cord-012418-6ralcn8p	232	33	system	system	NN
cord-012418-6ralcn8p	232	34	.	.	.
cord-012418-6ralcn8p	233	1	In	in	IN
cord-012418-6ralcn8p	233	2	non	non	JJ
cord-012418-6ralcn8p	233	3	-	-	JJ
cord-012418-6ralcn8p	233	4	infected	infected	JJ
cord-012418-6ralcn8p	233	5	mouse	mouse	NN
cord-012418-6ralcn8p	233	6	cells	cell	NNS
cord-012418-6ralcn8p	233	7	,	,	,
cord-012418-6ralcn8p	233	8	a	a	DT
cord-012418-6ralcn8p	233	9	proximal	proximal	JJ
cord-012418-6ralcn8p	233	10	region	region	NN
cord-012418-6ralcn8p	233	11	of	of	IN
cord-012418-6ralcn8p	233	12	the	the	DT
cord-012418-6ralcn8p	233	13	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	233	14	locus	locus	NN
cord-012418-6ralcn8p	233	15	that	that	WDT
cord-012418-6ralcn8p	233	16	contains	contain	VBZ
cord-012418-6ralcn8p	233	17	binding	bind	VBG
cord-012418-6ralcn8p	233	18	sites	site	NNS
cord-012418-6ralcn8p	233	19	for	for	IN
cord-012418-6ralcn8p	233	20	the	the	DT
cord-012418-6ralcn8p	233	21	transcription	transcription	NN
cord-012418-6ralcn8p	233	22	factor	factor	NN
cord-012418-6ralcn8p	233	23	Yin	Yin	NNP
cord-012418-6ralcn8p	233	24	Yang	Yang	NNP
cord-012418-6ralcn8p	233	25	1	1	CD
cord-012418-6ralcn8p	233	26	(	(	-LRB-
cord-012418-6ralcn8p	233	27	YY1	YY1	NNP
cord-012418-6ralcn8p	233	28	)	)	-RRB-
cord-012418-6ralcn8p	233	29	was	be	VBD
cord-012418-6ralcn8p	233	30	shown	show	VBN
cord-012418-6ralcn8p	233	31	to	to	TO
cord-012418-6ralcn8p	233	32	mediate	mediate	VB
cord-012418-6ralcn8p	233	33	association	association	NN
cord-012418-6ralcn8p	233	34	with	with	IN
cord-012418-6ralcn8p	233	35	pericentromeric	pericentromeric	NNP
cord-012418-6ralcn8p	233	36	heterochromatin	heterochromatin	NNP
cord-012418-6ralcn8p	233	37	(	(	-LRB-
cord-012418-6ralcn8p	233	38	PCH	PCH	NNP
cord-012418-6ralcn8p	233	39	)	)	-RRB-
cord-012418-6ralcn8p	233	40	,	,	,
cord-012418-6ralcn8p	233	41	a	a	DT
cord-012418-6ralcn8p	233	42	feature	feature	NN
cord-012418-6ralcn8p	233	43	related	relate	VBN
cord-012418-6ralcn8p	233	44	to	to	IN
cord-012418-6ralcn8p	233	45	gene	gene	NN
cord-012418-6ralcn8p	233	46	silencing	silence	VBG
cord-012418-6ralcn8p	233	47	[	[	-LRB-
cord-012418-6ralcn8p	233	48	119	119	CD
cord-012418-6ralcn8p	233	49	]	]	-RRB-
cord-012418-6ralcn8p	233	50	.	.	.
cord-012418-6ralcn8p	234	1	After	after	IN
cord-012418-6ralcn8p	234	2	infection	infection	NN
cord-012418-6ralcn8p	234	3	,	,	,
cord-012418-6ralcn8p	234	4	the	the	DT
cord-012418-6ralcn8p	234	5	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	234	6	locus	locus	NN
cord-012418-6ralcn8p	234	7	is	be	VBZ
cord-012418-6ralcn8p	234	8	repositioned	reposition	VBN
cord-012418-6ralcn8p	234	9	away	away	RB
cord-012418-6ralcn8p	234	10	from	from	IN
cord-012418-6ralcn8p	234	11	PCH	PCH	NNP
cord-012418-6ralcn8p	234	12	,	,	,
cord-012418-6ralcn8p	234	13	and	and	CC
cord-012418-6ralcn8p	234	14	this	this	DT
cord-012418-6ralcn8p	234	15	observation	observation	NN
cord-012418-6ralcn8p	234	16	correlated	correlate	VBD
cord-012418-6ralcn8p	234	17	with	with	IN
cord-012418-6ralcn8p	234	18	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	234	19	activation	activation	NN
cord-012418-6ralcn8p	234	20	of	of	IN
cord-012418-6ralcn8p	234	21	the	the	DT
cord-012418-6ralcn8p	234	22	promoter	promoter	NN
cord-012418-6ralcn8p	234	23	shortly	shortly	RB
cord-012418-6ralcn8p	234	24	thereafter	thereafter	RB
cord-012418-6ralcn8p	234	25	.	.	.
cord-012418-6ralcn8p	235	1	Josse	josse	NN
cord-012418-6ralcn8p	235	2	and	and	CC
cord-012418-6ralcn8p	235	3	colleagues	colleague	NNS
cord-012418-6ralcn8p	235	4	suggested	suggest	VBD
cord-012418-6ralcn8p	235	5	that	that	IN
cord-012418-6ralcn8p	235	6	this	this	DT
cord-012418-6ralcn8p	235	7	effect	effect	NN
cord-012418-6ralcn8p	235	8	could	could	MD
cord-012418-6ralcn8p	235	9	be	be	VB
cord-012418-6ralcn8p	235	10	mediated	mediate	VBN
cord-012418-6ralcn8p	235	11	by	by	IN
cord-012418-6ralcn8p	235	12	binding	bind	VBG
cord-012418-6ralcn8p	235	13	of	of	IN
cord-012418-6ralcn8p	235	14	YY1	YY1	NNP
cord-012418-6ralcn8p	235	15	to	to	IN
cord-012418-6ralcn8p	235	16	the	the	DT
cord-012418-6ralcn8p	235	17	proximal	proximal	JJ
cord-012418-6ralcn8p	235	18	promoter	promoter	NN
cord-012418-6ralcn8p	235	19	.	.	.
cord-012418-6ralcn8p	236	1	Furthermore	furthermore	RB
cord-012418-6ralcn8p	236	2	,	,	,
cord-012418-6ralcn8p	236	3	YY1	YY1	NNP
cord-012418-6ralcn8p	236	4	interacts	interact	VBZ
cord-012418-6ralcn8p	236	5	also	also	RB
cord-012418-6ralcn8p	236	6	in	in	IN
cord-012418-6ralcn8p	236	7	the	the	DT
cord-012418-6ralcn8p	236	8	absence	absence	NN
cord-012418-6ralcn8p	236	9	of	of	IN
cord-012418-6ralcn8p	236	10	viral	viral	JJ
cord-012418-6ralcn8p	236	11	infection	infection	NN
cord-012418-6ralcn8p	236	12	in	in	IN
cord-012418-6ralcn8p	236	13	mice	mouse	NNS
cord-012418-6ralcn8p	236	14	with	with	IN
cord-012418-6ralcn8p	236	15	the	the	DT
cord-012418-6ralcn8p	236	16	signal	signal	NN
cord-012418-6ralcn8p	236	17	transducer	transducer	NN
cord-012418-6ralcn8p	236	18	and	and	CC
cord-012418-6ralcn8p	236	19	activator	activator	NN
cord-012418-6ralcn8p	236	20	of	of	IN
cord-012418-6ralcn8p	236	21	transcription	transcription	NN
cord-012418-6ralcn8p	236	22	1	1	CD
cord-012418-6ralcn8p	236	23	(	(	-LRB-
cord-012418-6ralcn8p	236	24	STAT1	STAT1	NNP
cord-012418-6ralcn8p	236	25	)	)	-RRB-
cord-012418-6ralcn8p	236	26	,	,	,
cord-012418-6ralcn8p	236	27	one	one	CD
cord-012418-6ralcn8p	236	28	of	of	IN
cord-012418-6ralcn8p	236	29	the	the	DT
cord-012418-6ralcn8p	236	30	main	main	JJ
cord-012418-6ralcn8p	236	31	factors	factor	NNS
cord-012418-6ralcn8p	236	32	mediating	mediate	VBG
cord-012418-6ralcn8p	236	33	ISG	ISG	NNP
cord-012418-6ralcn8p	236	34	expression	expression	NN
cord-012418-6ralcn8p	236	35	[	[	-LRB-
cord-012418-6ralcn8p	236	36	35	35	CD
cord-012418-6ralcn8p	236	37	]	]	-RRB-
cord-012418-6ralcn8p	236	38	,	,	,
cord-012418-6ralcn8p	236	39	implying	imply	VBG
cord-012418-6ralcn8p	236	40	important	important	JJ
cord-012418-6ralcn8p	236	41	roles	role	NNS
cord-012418-6ralcn8p	236	42	of	of	IN
cord-012418-6ralcn8p	236	43	YY	YY	NNP
cord-012418-6ralcn8p	236	44	proteins	protein	NNS
cord-012418-6ralcn8p	236	45	at	at	IN
cord-012418-6ralcn8p	236	46	different	different	JJ
cord-012418-6ralcn8p	236	47	stages	stage	NNS
cord-012418-6ralcn8p	236	48	during	during	IN
cord-012418-6ralcn8p	236	49	infection	infection	NN
cord-012418-6ralcn8p	236	50	[	[	-LRB-
cord-012418-6ralcn8p	236	51	120	120	CD
cord-012418-6ralcn8p	236	52	]	]	-RRB-
cord-012418-6ralcn8p	236	53	.	.	.
cord-012418-6ralcn8p	237	1	In	in	IN
cord-012418-6ralcn8p	237	2	the	the	DT
cord-012418-6ralcn8p	237	3	human	human	JJ
cord-012418-6ralcn8p	237	4	cell	cell	NN
cord-012418-6ralcn8p	237	5	,	,	,
cord-012418-6ralcn8p	237	6	YY1	YY1	NNP
cord-012418-6ralcn8p	237	7	and	and	CC
cord-012418-6ralcn8p	237	8	YY2	YY2	NNS
cord-012418-6ralcn8p	237	9	regulate	regulate	VBP
cord-012418-6ralcn8p	237	10	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	237	11	formation	formation	NN
cord-012418-6ralcn8p	237	12	from	from	IN
cord-012418-6ralcn8p	237	13	YY	yy	NN
cord-012418-6ralcn8p	237	14	-	-	HYPH
cord-012418-6ralcn8p	237	15	binding	bind	VBG
cord-012418-6ralcn8p	237	16	site	site	NN
cord-012418-6ralcn8p	237	17	-	-	HYPH
cord-012418-6ralcn8p	237	18	containing	contain	VBG
cord-012418-6ralcn8p	237	19	regions	region	NNS
cord-012418-6ralcn8p	237	20	far	far	RB
cord-012418-6ralcn8p	237	21	upstream	upstream	RB
cord-012418-6ralcn8p	237	22	of	of	IN
cord-012418-6ralcn8p	237	23	the	the	DT
cord-012418-6ralcn8p	237	24	TSS	TSS	NNP
cord-012418-6ralcn8p	237	25	of	of	IN
cord-012418-6ralcn8p	237	26	the	the	DT
cord-012418-6ralcn8p	237	27	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	237	28	gene	gene	NN
cord-012418-6ralcn8p	237	29	at	at	IN
cord-012418-6ralcn8p	237	30	−3	−3	NNP
cord-012418-6ralcn8p	237	31	kb	kb	NNP
cord-012418-6ralcn8p	237	32	and	and	CC
cord-012418-6ralcn8p	237	33	−2	−2	NNP
cord-012418-6ralcn8p	237	34	kb	kb	NNP
cord-012418-6ralcn8p	237	35	,	,	,
cord-012418-6ralcn8p	237	36	termed	term	VBN
cord-012418-6ralcn8p	238	1	DNase	DNase	NNP
cord-012418-6ralcn8p	239	1	I	-PRON-	PRP
cord-012418-6ralcn8p	239	2	hypersensitive	hypersensitive	JJ
cord-012418-6ralcn8p	239	3	sites	site	NNS
cord-012418-6ralcn8p	239	4	1	1	CD
cord-012418-6ralcn8p	239	5	(	(	-LRB-
cord-012418-6ralcn8p	239	6	HS1	HS1	NNP
cord-012418-6ralcn8p	239	7	)	)	-RRB-
cord-012418-6ralcn8p	239	8	and	and	CC
cord-012418-6ralcn8p	239	9	HS2	HS2	NNP
cord-012418-6ralcn8p	239	10	,	,	,
cord-012418-6ralcn8p	239	11	respectively	respectively	RB
cord-012418-6ralcn8p	239	12	[	[	-LRB-
cord-012418-6ralcn8p	239	13	121	121	CD
cord-012418-6ralcn8p	239	14	]	]	-RRB-
cord-012418-6ralcn8p	239	15	.	.	.
cord-012418-6ralcn8p	240	1	YY1	YY1	NNP
cord-012418-6ralcn8p	240	2	and	and	CC
cord-012418-6ralcn8p	240	3	YY2	YY2	NNS
cord-012418-6ralcn8p	240	4	seem	seem	VBP
cord-012418-6ralcn8p	240	5	to	to	TO
cord-012418-6ralcn8p	240	6	modulate	modulate	VB
cord-012418-6ralcn8p	240	7	each	each	DT
cord-012418-6ralcn8p	240	8	other	other	JJ
cord-012418-6ralcn8p	240	9	,	,	,
cord-012418-6ralcn8p	240	10	with	with	IN
cord-012418-6ralcn8p	240	11	YY2	YY2	NNS
cord-012418-6ralcn8p	240	12	antagonising	antagonise	VBG
cord-012418-6ralcn8p	240	13	the	the	DT
cord-012418-6ralcn8p	240	14	negative	negative	JJ
cord-012418-6ralcn8p	240	15	effect	effect	NN
cord-012418-6ralcn8p	240	16	of	of	IN
cord-012418-6ralcn8p	240	17	YY1	YY1	NNP
cord-012418-6ralcn8p	240	18	.	.	.
cord-012418-6ralcn8p	241	1	In	in	IN
cord-012418-6ralcn8p	241	2	analogy	analogy	NN
cord-012418-6ralcn8p	241	3	to	to	IN
cord-012418-6ralcn8p	241	4	the	the	DT
cord-012418-6ralcn8p	241	5	murine	murine	JJ
cord-012418-6ralcn8p	241	6	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	241	7	promoter	promoter	NN
cord-012418-6ralcn8p	241	8	region	region	NN
cord-012418-6ralcn8p	241	9	,	,	,
cord-012418-6ralcn8p	241	10	this	this	DT
cord-012418-6ralcn8p	241	11	long	long	JJ
cord-012418-6ralcn8p	241	12	-	-	HYPH
cord-012418-6ralcn8p	241	13	range	range	NN
cord-012418-6ralcn8p	241	14	interaction	interaction	NN
cord-012418-6ralcn8p	241	15	was	be	VBD
cord-012418-6ralcn8p	241	16	suggested	suggest	VBN
cord-012418-6ralcn8p	241	17	as	as	IN
cord-012418-6ralcn8p	241	18	requirement	requirement	NN
cord-012418-6ralcn8p	241	19	for	for	IN
cord-012418-6ralcn8p	241	20	the	the	DT
cord-012418-6ralcn8p	241	21	recruitment	recruitment	NN
cord-012418-6ralcn8p	241	22	of	of	IN
cord-012418-6ralcn8p	241	23	GCN5	GCN5	NNP
cord-012418-6ralcn8p	241	24	to	to	TO
cord-012418-6ralcn8p	241	25	initiate	initiate	VB
cord-012418-6ralcn8p	241	26	chromatin	chromatin	NN
cord-012418-6ralcn8p	241	27	remodelling	remodelling	NN
cord-012418-6ralcn8p	241	28	at	at	IN
cord-012418-6ralcn8p	241	29	the	the	DT
cord-012418-6ralcn8p	241	30	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	241	31	promoter	promoter	NN
cord-012418-6ralcn8p	241	32	[	[	-LRB-
cord-012418-6ralcn8p	241	33	121	121	CD
cord-012418-6ralcn8p	241	34	]	]	-RRB-
cord-012418-6ralcn8p	241	35	[	[	-LRB-
cord-012418-6ralcn8p	241	36	122	122	CD
cord-012418-6ralcn8p	241	37	]	]	-RRB-
cord-012418-6ralcn8p	241	38	[	[	-LRB-
cord-012418-6ralcn8p	241	39	123	123	CD
cord-012418-6ralcn8p	241	40	]	]	-RRB-
cord-012418-6ralcn8p	241	41	.	.	.
cord-012418-6ralcn8p	242	1	A	a	DT
cord-012418-6ralcn8p	242	2	further	further	JJ
cord-012418-6ralcn8p	242	3	DNA	dna	NN
cord-012418-6ralcn8p	242	4	element	element	NN
cord-012418-6ralcn8p	242	5	regulating	regulate	VBG
cord-012418-6ralcn8p	242	6	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	242	7	transcription	transcription	NN
cord-012418-6ralcn8p	242	8	is	be	VBZ
cord-012418-6ralcn8p	242	9	the	the	DT
cord-012418-6ralcn8p	242	10	long	long	JJ
cord-012418-6ralcn8p	242	11	-	-	HYPH
cord-012418-6ralcn8p	242	12	range	range	NN
cord-012418-6ralcn8p	242	13	enhancer	enhancer	NN
cord-012418-6ralcn8p	242	14	L2	l2	NN
cord-012418-6ralcn8p	242	15	,	,	,
cord-012418-6ralcn8p	242	16	which	which	WDT
cord-012418-6ralcn8p	242	17	was	be	VBD
cord-012418-6ralcn8p	242	18	first	first	RB
cord-012418-6ralcn8p	242	19	identified	identify	VBN
cord-012418-6ralcn8p	242	20	in	in	IN
cord-012418-6ralcn8p	242	21	human	human	JJ
cord-012418-6ralcn8p	242	22	cells	cell	NNS
cord-012418-6ralcn8p	242	23	but	but	CC
cord-012418-6ralcn8p	242	24	is	be	VBZ
cord-012418-6ralcn8p	242	25	conserved	conserve	VBN
cord-012418-6ralcn8p	242	26	in	in	IN
cord-012418-6ralcn8p	242	27	mice	mouse	NNS
cord-012418-6ralcn8p	242	28	[	[	-LRB-
cord-012418-6ralcn8p	242	29	124	124	CD
cord-012418-6ralcn8p	242	30	]	]	-RRB-
cord-012418-6ralcn8p	242	31	.	.	.
cord-012418-6ralcn8p	243	1	L2	L2	NNP
cord-012418-6ralcn8p	243	2	is	be	VBZ
cord-012418-6ralcn8p	243	3	activated	activate	VBN
cord-012418-6ralcn8p	243	4	upon	upon	IN
cord-012418-6ralcn8p	243	5	viral	viral	JJ
cord-012418-6ralcn8p	243	6	stimulation	stimulation	NN
cord-012418-6ralcn8p	243	7	and	and	CC
cord-012418-6ralcn8p	243	8	recruits	recruit	VBZ
cord-012418-6ralcn8p	243	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	243	10	and	and	CC
cord-012418-6ralcn8p	243	11	RNAP	RNAP	NNP
cord-012418-6ralcn8p	243	12	II	II	NNP
cord-012418-6ralcn8p	243	13	dependent	dependent	JJ
cord-012418-6ralcn8p	243	14	on	on	IN
cord-012418-6ralcn8p	243	15	the	the	DT
cord-012418-6ralcn8p	243	16	IRF	IRF	NNP
cord-012418-6ralcn8p	243	17	-	-	HYPH
cord-012418-6ralcn8p	243	18	E	E	NNP
cord-012418-6ralcn8p	243	19	within	within	IN
cord-012418-6ralcn8p	243	20	its	-PRON-	PRP$
cord-012418-6ralcn8p	243	21	interferon	interferon	NN
cord-012418-6ralcn8p	243	22	-	-	HYPH
cord-012418-6ralcn8p	243	23	stimulated	stimulate	VBN
cord-012418-6ralcn8p	243	24	response	response	NN
cord-012418-6ralcn8p	243	25	element	element	NN
cord-012418-6ralcn8p	243	26	(	(	-LRB-
cord-012418-6ralcn8p	243	27	ISRE	ISRE	NNP
cord-012418-6ralcn8p	243	28	)	)	-RRB-
cord-012418-6ralcn8p	243	29	.	.	.
cord-012418-6ralcn8p	244	1	This	this	DT
cord-012418-6ralcn8p	244	2	induces	induce	VBZ
cord-012418-6ralcn8p	244	3	expression	expression	NN
cord-012418-6ralcn8p	244	4	of	of	IN
cord-012418-6ralcn8p	244	5	a	a	DT
cord-012418-6ralcn8p	244	6	non	non	JJ
cord-012418-6ralcn8p	244	7	-	-	JJ
cord-012418-6ralcn8p	244	8	coding	coding	JJ
cord-012418-6ralcn8p	244	9	RNA	rna	NN
cord-012418-6ralcn8p	244	10	from	from	IN
cord-012418-6ralcn8p	244	11	the	the	DT
cord-012418-6ralcn8p	244	12	enhancer	enhancer	NN
cord-012418-6ralcn8p	244	13	,	,	,
cord-012418-6ralcn8p	244	14	and	and	CC
cord-012418-6ralcn8p	244	15	this	this	DT
cord-012418-6ralcn8p	244	16	enhancer	enhancer	NN
cord-012418-6ralcn8p	244	17	RNA	RNA	NNP
cord-012418-6ralcn8p	244	18	(	(	-LRB-
cord-012418-6ralcn8p	244	19	eRNA	eRNA	NNS
cord-012418-6ralcn8p	244	20	)	)	-RRB-
cord-012418-6ralcn8p	244	21	in	in	IN
cord-012418-6ralcn8p	244	22	turn	turn	NN
cord-012418-6ralcn8p	244	23	supports	support	VBZ
cord-012418-6ralcn8p	244	24	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	244	25	expression	expression	NN
cord-012418-6ralcn8p	244	26	.	.	.
cord-012418-6ralcn8p	245	1	However	however	RB
cord-012418-6ralcn8p	245	2	,	,	,
cord-012418-6ralcn8p	245	3	the	the	DT
cord-012418-6ralcn8p	245	4	mode	mode	NN
cord-012418-6ralcn8p	245	5	of	of	IN
cord-012418-6ralcn8p	245	6	action	action	NN
cord-012418-6ralcn8p	245	7	of	of	IN
cord-012418-6ralcn8p	245	8	the	the	DT
cord-012418-6ralcn8p	245	9	eRNA	erna	NN
cord-012418-6ralcn8p	245	10	was	be	VBD
cord-012418-6ralcn8p	245	11	not	not	RB
cord-012418-6ralcn8p	245	12	yet	yet	RB
cord-012418-6ralcn8p	245	13	determined	determined	JJ
cord-012418-6ralcn8p	245	14	.	.	.
cord-012418-6ralcn8p	246	1	The	the	DT
cord-012418-6ralcn8p	246	2	rapid	rapid	JJ
cord-012418-6ralcn8p	246	3	induction	induction	NN
cord-012418-6ralcn8p	246	4	of	of	IN
cord-012418-6ralcn8p	246	5	the	the	DT
cord-012418-6ralcn8p	246	6	antiviral	antiviral	JJ
cord-012418-6ralcn8p	246	7	state	state	NN
cord-012418-6ralcn8p	246	8	is	be	VBZ
cord-012418-6ralcn8p	246	9	critical	critical	JJ
cord-012418-6ralcn8p	246	10	to	to	TO
cord-012418-6ralcn8p	246	11	overcome	overcome	VB
cord-012418-6ralcn8p	246	12	a	a	DT
cord-012418-6ralcn8p	246	13	nascent	nascent	JJ
cord-012418-6ralcn8p	246	14	infection	infection	NN
cord-012418-6ralcn8p	246	15	.	.	.
cord-012418-6ralcn8p	247	1	While	while	IN
cord-012418-6ralcn8p	247	2	an	an	DT
cord-012418-6ralcn8p	247	3	insufficient	insufficient	JJ
cord-012418-6ralcn8p	247	4	response	response	NN
cord-012418-6ralcn8p	247	5	would	would	MD
cord-012418-6ralcn8p	247	6	be	be	VB
cord-012418-6ralcn8p	247	7	beneficial	beneficial	JJ
cord-012418-6ralcn8p	247	8	for	for	IN
cord-012418-6ralcn8p	247	9	the	the	DT
cord-012418-6ralcn8p	247	10	pathogen	pathogen	NN
cord-012418-6ralcn8p	247	11	,	,	,
cord-012418-6ralcn8p	247	12	overshooting	overshoot	VBG
cord-012418-6ralcn8p	247	13	activation	activation	NN
cord-012418-6ralcn8p	247	14	of	of	IN
cord-012418-6ralcn8p	247	15	the	the	DT
cord-012418-6ralcn8p	247	16	immune	immune	JJ
cord-012418-6ralcn8p	247	17	system	system	NN
cord-012418-6ralcn8p	247	18	can	can	MD
cord-012418-6ralcn8p	247	19	cause	cause	VB
cord-012418-6ralcn8p	247	20	severe	severe	JJ
cord-012418-6ralcn8p	247	21	damage	damage	NN
cord-012418-6ralcn8p	247	22	to	to	IN
cord-012418-6ralcn8p	247	23	the	the	DT
cord-012418-6ralcn8p	247	24	organism	organism	NN
cord-012418-6ralcn8p	247	25	.	.	.
cord-012418-6ralcn8p	248	1	Therefore	therefore	RB
cord-012418-6ralcn8p	248	2	,	,	,
cord-012418-6ralcn8p	248	3	several	several	JJ
cord-012418-6ralcn8p	248	4	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	248	5	are	be	VBP
cord-012418-6ralcn8p	248	6	implemented	implement	VBN
cord-012418-6ralcn8p	248	7	by	by	IN
cord-012418-6ralcn8p	248	8	the	the	DT
cord-012418-6ralcn8p	248	9	host	host	NN
cord-012418-6ralcn8p	248	10	organism	organism	NN
cord-012418-6ralcn8p	248	11	to	to	TO
cord-012418-6ralcn8p	248	12	regulate	regulate	VB
cord-012418-6ralcn8p	248	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	248	14	at	at	IN
cord-012418-6ralcn8p	248	15	all	all	DT
cord-012418-6ralcn8p	248	16	levels	level	NNS
cord-012418-6ralcn8p	248	17	,	,	,
cord-012418-6ralcn8p	248	18	from	from	IN
cord-012418-6ralcn8p	248	19	moderating	moderate	VBG
cord-012418-6ralcn8p	248	20	the	the	DT
cord-012418-6ralcn8p	248	21	potential	potential	NN
cord-012418-6ralcn8p	248	22	to	to	TO
cord-012418-6ralcn8p	248	23	activate	activate	VB
cord-012418-6ralcn8p	248	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	248	25	from	from	IN
cord-012418-6ralcn8p	248	26	its	-PRON-	PRP$
cord-012418-6ralcn8p	248	27	latent	latent	JJ
cord-012418-6ralcn8p	248	28	state	state	NN
cord-012418-6ralcn8p	248	29	,	,	,
cord-012418-6ralcn8p	248	30	to	to	IN
cord-012418-6ralcn8p	248	31	promoting	promote	VBG
cord-012418-6ralcn8p	248	32	its	-PRON-	PRP$
cord-012418-6ralcn8p	248	33	participation	participation	NN
cord-012418-6ralcn8p	248	34	in	in	IN
cord-012418-6ralcn8p	248	35	formation	formation	NN
cord-012418-6ralcn8p	248	36	of	of	IN
cord-012418-6ralcn8p	248	37	the	the	DT
cord-012418-6ralcn8p	248	38	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	248	39	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	248	40	,	,	,
cord-012418-6ralcn8p	248	41	to	to	IN
cord-012418-6ralcn8p	248	42	supporting	support	VBG
cord-012418-6ralcn8p	248	43	its	-PRON-	PRP$
cord-012418-6ralcn8p	248	44	activity	activity	NN
cord-012418-6ralcn8p	248	45	during	during	IN
cord-012418-6ralcn8p	248	46	ongoing	ongoing	JJ
cord-012418-6ralcn8p	248	47	stimulation	stimulation	NN
cord-012418-6ralcn8p	248	48	,	,	,
cord-012418-6ralcn8p	248	49	through	through	IN
cord-012418-6ralcn8p	248	50	to	to	IN
cord-012418-6ralcn8p	248	51	terminating	terminate	VBG
cord-012418-6ralcn8p	248	52	the	the	DT
cord-012418-6ralcn8p	248	53	response	response	NN
cord-012418-6ralcn8p	248	54	with	with	IN
cord-012418-6ralcn8p	248	55	deliberate	deliberate	JJ
cord-012418-6ralcn8p	248	56	timing	timing	NN
cord-012418-6ralcn8p	248	57	.	.	.
cord-012418-6ralcn8p	249	1	Factors	factor	NNS
cord-012418-6ralcn8p	249	2	that	that	WDT
cord-012418-6ralcn8p	249	3	contribute	contribute	VBP
cord-012418-6ralcn8p	249	4	to	to	IN
cord-012418-6ralcn8p	249	5	the	the	DT
cord-012418-6ralcn8p	249	6	finely	finely	RB
cord-012418-6ralcn8p	249	7	tuned	tune	VBN
cord-012418-6ralcn8p	249	8	ensemble	ensemble	NN
cord-012418-6ralcn8p	249	9	of	of	IN
cord-012418-6ralcn8p	249	10	modulators	modulator	NNS
cord-012418-6ralcn8p	249	11	can	can	MD
cord-012418-6ralcn8p	249	12	be	be	VB
cord-012418-6ralcn8p	249	13	continuously	continuously	RB
cord-012418-6ralcn8p	249	14	active	active	JJ
cord-012418-6ralcn8p	249	15	,	,	,
cord-012418-6ralcn8p	249	16	induced	induce	VBN
cord-012418-6ralcn8p	249	17	or	or	CC
cord-012418-6ralcn8p	249	18	inhibited	inhibit	VBN
cord-012418-6ralcn8p	249	19	upon	upon	IN
cord-012418-6ralcn8p	249	20	stimulation	stimulation	NN
cord-012418-6ralcn8p	249	21	.	.	.
cord-012418-6ralcn8p	250	1	A	a	DT
cord-012418-6ralcn8p	250	2	wide	wide	JJ
cord-012418-6ralcn8p	250	3	array	array	NN
cord-012418-6ralcn8p	250	4	of	of	IN
cord-012418-6ralcn8p	250	5	molecular	molecular	JJ
cord-012418-6ralcn8p	250	6	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	250	7	that	that	WDT
cord-012418-6ralcn8p	250	8	modulate	modulate	VBP
cord-012418-6ralcn8p	250	9	the	the	DT
cord-012418-6ralcn8p	250	10	biological	biological	JJ
cord-012418-6ralcn8p	250	11	activity	activity	NN
cord-012418-6ralcn8p	250	12	of	of	IN
cord-012418-6ralcn8p	250	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	250	14	are	be	VBP
cord-012418-6ralcn8p	250	15	deployed	deploy	VBN
cord-012418-6ralcn8p	250	16	,	,	,
cord-012418-6ralcn8p	250	17	including	include	VBG
cord-012418-6ralcn8p	250	18	protein	protein	NN
cord-012418-6ralcn8p	250	19	-	-	HYPH
cord-012418-6ralcn8p	250	20	protein	protein	NN
cord-012418-6ralcn8p	250	21	interactions	interaction	NNS
cord-012418-6ralcn8p	250	22	,	,	,
cord-012418-6ralcn8p	250	23	regulatory	regulatory	JJ
cord-012418-6ralcn8p	250	24	RNAs	rna	NNS
cord-012418-6ralcn8p	250	25	and	and	CC
cord-012418-6ralcn8p	250	26	common	common	JJ
cord-012418-6ralcn8p	250	27	as	as	RB
cord-012418-6ralcn8p	250	28	well	well	RB
cord-012418-6ralcn8p	250	29	as	as	IN
cord-012418-6ralcn8p	250	30	non	non	JJ
cord-012418-6ralcn8p	250	31	-	-	JJ
cord-012418-6ralcn8p	250	32	canonical	canonical	JJ
cord-012418-6ralcn8p	250	33	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	250	34	modifications	modification	NNS
cord-012418-6ralcn8p	250	35	.	.	.
cord-012418-6ralcn8p	251	1	To	to	TO
cord-012418-6ralcn8p	251	2	illustrate	illustrate	VB
cord-012418-6ralcn8p	251	3	the	the	DT
cord-012418-6ralcn8p	251	4	abundance	abundance	NN
cord-012418-6ralcn8p	251	5	of	of	IN
cord-012418-6ralcn8p	251	6	strategies	strategy	NNS
cord-012418-6ralcn8p	251	7	,	,	,
cord-012418-6ralcn8p	251	8	we	-PRON-	PRP
cord-012418-6ralcn8p	251	9	will	will	MD
cord-012418-6ralcn8p	251	10	include	include	VB
cord-012418-6ralcn8p	251	11	also	also	RB
cord-012418-6ralcn8p	251	12	proteins	protein	NNS
cord-012418-6ralcn8p	251	13	expressed	express	VBN
cord-012418-6ralcn8p	251	14	predominantly	predominantly	RB
cord-012418-6ralcn8p	251	15	in	in	IN
cord-012418-6ralcn8p	251	16	immune	immune	JJ
cord-012418-6ralcn8p	251	17	cells	cell	NNS
cord-012418-6ralcn8p	251	18	.	.	.
cord-012418-6ralcn8p	252	1	In	in	IN
cord-012418-6ralcn8p	252	2	particular	particular	JJ
cord-012418-6ralcn8p	252	3	,	,	,
cord-012418-6ralcn8p	252	4	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	252	5	aiming	aim	VBG
cord-012418-6ralcn8p	252	6	at	at	IN
cord-012418-6ralcn8p	252	7	dampening	dampen	VBG
cord-012418-6ralcn8p	252	8	the	the	DT
cord-012418-6ralcn8p	252	9	activity	activity	NN
cord-012418-6ralcn8p	252	10	of	of	IN
cord-012418-6ralcn8p	252	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	252	12	were	be	VBD
cord-012418-6ralcn8p	252	13	usually	usually	RB
cord-012418-6ralcn8p	252	14	identified	identify	VBN
cord-012418-6ralcn8p	252	15	in	in	IN
cord-012418-6ralcn8p	252	16	macrophages	macrophage	NNS
cord-012418-6ralcn8p	252	17	,	,	,
cord-012418-6ralcn8p	252	18	highlighting	highlight	VBG
cord-012418-6ralcn8p	252	19	the	the	DT
cord-012418-6ralcn8p	252	20	importance	importance	NN
cord-012418-6ralcn8p	252	21	to	to	TO
cord-012418-6ralcn8p	252	22	keep	keep	VB
cord-012418-6ralcn8p	252	23	the	the	DT
cord-012418-6ralcn8p	252	24	response	response	NN
cord-012418-6ralcn8p	252	25	primed	prime	VBN
cord-012418-6ralcn8p	252	26	but	but	CC
cord-012418-6ralcn8p	252	27	low	low	JJ
cord-012418-6ralcn8p	252	28	until	until	IN
cord-012418-6ralcn8p	252	29	the	the	DT
cord-012418-6ralcn8p	252	30	full	full	JJ
cord-012418-6ralcn8p	252	31	activation	activation	NN
cord-012418-6ralcn8p	252	32	becomes	become	VBZ
cord-012418-6ralcn8p	252	33	necessary	necessary	JJ
cord-012418-6ralcn8p	252	34	.	.	.
cord-012418-6ralcn8p	253	1	Since	since	IN
cord-012418-6ralcn8p	253	2	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	253	3	modifications	modification	NNS
cord-012418-6ralcn8p	253	4	of	of	IN
cord-012418-6ralcn8p	253	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	253	6	and	and	CC
cord-012418-6ralcn8p	253	7	especially	especially	RB
cord-012418-6ralcn8p	253	8	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	253	9	and	and	CC
cord-012418-6ralcn8p	253	10	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	253	11	were	be	VBD
cord-012418-6ralcn8p	253	12	reviewed	review	VBN
cord-012418-6ralcn8p	253	13	before	before	IN
cord-012418-6ralcn8p	253	14	[	[	-LRB-
cord-012418-6ralcn8p	253	15	125	125	CD
cord-012418-6ralcn8p	253	16	,	,	,
cord-012418-6ralcn8p	253	17	126	126	CD
cord-012418-6ralcn8p	253	18	]	]	-RRB-
cord-012418-6ralcn8p	253	19	,	,	,
cord-012418-6ralcn8p	253	20	we	-PRON-	PRP
cord-012418-6ralcn8p	253	21	will	will	MD
cord-012418-6ralcn8p	253	22	instead	instead	RB
cord-012418-6ralcn8p	253	23	focus	focus	VB
cord-012418-6ralcn8p	253	24	on	on	IN
cord-012418-6ralcn8p	253	25	how	how	WRB
cord-012418-6ralcn8p	253	26	the	the	DT
cord-012418-6ralcn8p	253	27	host	host	NN
cord-012418-6ralcn8p	253	28	factors	factor	NNS
cord-012418-6ralcn8p	253	29	engage	engage	VBP
cord-012418-6ralcn8p	253	30	in	in	IN
cord-012418-6ralcn8p	253	31	the	the	DT
cord-012418-6ralcn8p	253	32	different	different	JJ
cord-012418-6ralcn8p	253	33	steps	step	NNS
cord-012418-6ralcn8p	253	34	to	to	TO
cord-012418-6ralcn8p	253	35	modulate	modulate	VB
cord-012418-6ralcn8p	253	36	the	the	DT
cord-012418-6ralcn8p	253	37	biologic	biologic	JJ
cord-012418-6ralcn8p	253	38	activity	activity	NN
cord-012418-6ralcn8p	253	39	of	of	IN
cord-012418-6ralcn8p	253	40	IRF3	IRF3	NNP
cord-012418-6ralcn8p	254	1	(	(	-LRB-
cord-012418-6ralcn8p	254	2	Figure	figure	NN
cord-012418-6ralcn8p	254	3	3	3	CD
cord-012418-6ralcn8p	254	4	)	)	-RRB-
cord-012418-6ralcn8p	254	5	.	.	.
cord-012418-6ralcn8p	255	1	Viruses	virus	NNS
cord-012418-6ralcn8p	255	2	2020	2020	CD
cord-012418-6ralcn8p	255	3	,	,	,
cord-012418-6ralcn8p	255	4	12	12	CD
cord-012418-6ralcn8p	255	5	,	,	,
cord-012418-6ralcn8p	255	6	x	x	NN
cord-012418-6ralcn8p	255	7	FOR	for	IN
cord-012418-6ralcn8p	255	8	PEER	peer	NN
cord-012418-6ralcn8p	255	9	REVIEW	REVIEW	NNP
cord-012418-6ralcn8p	255	10	11	11	CD
cord-012418-6ralcn8p	255	11	of	of	IN
cord-012418-6ralcn8p	255	12	33	33	CD
cord-012418-6ralcn8p	255	13	system	system	NN
cord-012418-6ralcn8p	255	14	can	can	MD
cord-012418-6ralcn8p	255	15	cause	cause	VB
cord-012418-6ralcn8p	255	16	severe	severe	JJ
cord-012418-6ralcn8p	255	17	damage	damage	NN
cord-012418-6ralcn8p	255	18	to	to	IN
cord-012418-6ralcn8p	255	19	the	the	DT
cord-012418-6ralcn8p	255	20	organism	organism	NN
cord-012418-6ralcn8p	255	21	.	.	.
cord-012418-6ralcn8p	256	1	Therefore	therefore	RB
cord-012418-6ralcn8p	256	2	,	,	,
cord-012418-6ralcn8p	256	3	several	several	JJ
cord-012418-6ralcn8p	256	4	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	256	5	are	be	VBP
cord-012418-6ralcn8p	256	6	implemented	implement	VBN
cord-012418-6ralcn8p	256	7	by	by	IN
cord-012418-6ralcn8p	256	8	the	the	DT
cord-012418-6ralcn8p	256	9	host	host	NN
cord-012418-6ralcn8p	256	10	organism	organism	NN
cord-012418-6ralcn8p	256	11	to	to	TO
cord-012418-6ralcn8p	256	12	regulate	regulate	VB
cord-012418-6ralcn8p	256	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	256	14	at	at	IN
cord-012418-6ralcn8p	256	15	all	all	DT
cord-012418-6ralcn8p	256	16	levels	level	NNS
cord-012418-6ralcn8p	256	17	,	,	,
cord-012418-6ralcn8p	256	18	from	from	IN
cord-012418-6ralcn8p	256	19	moderating	moderate	VBG
cord-012418-6ralcn8p	256	20	the	the	DT
cord-012418-6ralcn8p	256	21	potential	potential	NN
cord-012418-6ralcn8p	256	22	to	to	TO
cord-012418-6ralcn8p	256	23	activate	activate	VB
cord-012418-6ralcn8p	256	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	256	25	from	from	IN
cord-012418-6ralcn8p	256	26	its	-PRON-	PRP$
cord-012418-6ralcn8p	256	27	latent	latent	JJ
cord-012418-6ralcn8p	256	28	state	state	NN
cord-012418-6ralcn8p	256	29	,	,	,
cord-012418-6ralcn8p	256	30	to	to	IN
cord-012418-6ralcn8p	256	31	promoting	promote	VBG
cord-012418-6ralcn8p	256	32	its	-PRON-	PRP$
cord-012418-6ralcn8p	256	33	participation	participation	NN
cord-012418-6ralcn8p	256	34	in	in	IN
cord-012418-6ralcn8p	256	35	formation	formation	NN
cord-012418-6ralcn8p	256	36	of	of	IN
cord-012418-6ralcn8p	256	37	the	the	DT
cord-012418-6ralcn8p	256	38	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	256	39	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	256	40	,	,	,
cord-012418-6ralcn8p	256	41	to	to	IN
cord-012418-6ralcn8p	256	42	supporting	support	VBG
cord-012418-6ralcn8p	256	43	its	-PRON-	PRP$
cord-012418-6ralcn8p	256	44	activity	activity	NN
cord-012418-6ralcn8p	256	45	during	during	IN
cord-012418-6ralcn8p	256	46	ongoing	ongoing	JJ
cord-012418-6ralcn8p	256	47	stimulation	stimulation	NN
cord-012418-6ralcn8p	256	48	,	,	,
cord-012418-6ralcn8p	256	49	through	through	IN
cord-012418-6ralcn8p	256	50	to	to	IN
cord-012418-6ralcn8p	256	51	terminating	terminate	VBG
cord-012418-6ralcn8p	256	52	the	the	DT
cord-012418-6ralcn8p	256	53	response	response	NN
cord-012418-6ralcn8p	256	54	with	with	IN
cord-012418-6ralcn8p	256	55	deliberate	deliberate	JJ
cord-012418-6ralcn8p	256	56	timing	timing	NN
cord-012418-6ralcn8p	256	57	.	.	.
cord-012418-6ralcn8p	257	1	Factors	factor	NNS
cord-012418-6ralcn8p	257	2	that	that	WDT
cord-012418-6ralcn8p	257	3	contribute	contribute	VBP
cord-012418-6ralcn8p	257	4	to	to	IN
cord-012418-6ralcn8p	257	5	the	the	DT
cord-012418-6ralcn8p	257	6	finely	finely	RB
cord-012418-6ralcn8p	257	7	tuned	tune	VBN
cord-012418-6ralcn8p	257	8	ensemble	ensemble	NN
cord-012418-6ralcn8p	257	9	of	of	IN
cord-012418-6ralcn8p	257	10	modulators	modulator	NNS
cord-012418-6ralcn8p	257	11	can	can	MD
cord-012418-6ralcn8p	257	12	be	be	VB
cord-012418-6ralcn8p	257	13	continuously	continuously	RB
cord-012418-6ralcn8p	257	14	active	active	JJ
cord-012418-6ralcn8p	257	15	,	,	,
cord-012418-6ralcn8p	257	16	induced	induce	VBN
cord-012418-6ralcn8p	257	17	or	or	CC
cord-012418-6ralcn8p	257	18	inhibited	inhibit	VBN
cord-012418-6ralcn8p	257	19	upon	upon	IN
cord-012418-6ralcn8p	257	20	stimulation	stimulation	NN
cord-012418-6ralcn8p	257	21	.	.	.
cord-012418-6ralcn8p	258	1	A	a	DT
cord-012418-6ralcn8p	258	2	wide	wide	JJ
cord-012418-6ralcn8p	258	3	array	array	NN
cord-012418-6ralcn8p	258	4	of	of	IN
cord-012418-6ralcn8p	258	5	molecular	molecular	JJ
cord-012418-6ralcn8p	258	6	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	258	7	that	that	WDT
cord-012418-6ralcn8p	258	8	modulate	modulate	VBP
cord-012418-6ralcn8p	258	9	the	the	DT
cord-012418-6ralcn8p	258	10	biological	biological	JJ
cord-012418-6ralcn8p	258	11	activity	activity	NN
cord-012418-6ralcn8p	258	12	of	of	IN
cord-012418-6ralcn8p	258	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	258	14	are	be	VBP
cord-012418-6ralcn8p	258	15	deployed	deploy	VBN
cord-012418-6ralcn8p	258	16	,	,	,
cord-012418-6ralcn8p	258	17	including	include	VBG
cord-012418-6ralcn8p	258	18	protein	protein	NN
cord-012418-6ralcn8p	258	19	-	-	HYPH
cord-012418-6ralcn8p	258	20	protein	protein	NN
cord-012418-6ralcn8p	258	21	interactions	interaction	NNS
cord-012418-6ralcn8p	258	22	,	,	,
cord-012418-6ralcn8p	258	23	regulatory	regulatory	JJ
cord-012418-6ralcn8p	258	24	RNAs	rna	NNS
cord-012418-6ralcn8p	258	25	and	and	CC
cord-012418-6ralcn8p	258	26	common	common	JJ
cord-012418-6ralcn8p	258	27	as	as	RB
cord-012418-6ralcn8p	258	28	well	well	RB
cord-012418-6ralcn8p	258	29	as	as	IN
cord-012418-6ralcn8p	258	30	non	non	JJ
cord-012418-6ralcn8p	258	31	-	-	JJ
cord-012418-6ralcn8p	258	32	canonical	canonical	JJ
cord-012418-6ralcn8p	258	33	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	258	34	modifications	modification	NNS
cord-012418-6ralcn8p	258	35	.	.	.
cord-012418-6ralcn8p	259	1	To	to	TO
cord-012418-6ralcn8p	259	2	illustrate	illustrate	VB
cord-012418-6ralcn8p	259	3	the	the	DT
cord-012418-6ralcn8p	259	4	abundance	abundance	NN
cord-012418-6ralcn8p	259	5	of	of	IN
cord-012418-6ralcn8p	259	6	strategies	strategy	NNS
cord-012418-6ralcn8p	259	7	,	,	,
cord-012418-6ralcn8p	259	8	we	-PRON-	PRP
cord-012418-6ralcn8p	259	9	will	will	MD
cord-012418-6ralcn8p	259	10	include	include	VB
cord-012418-6ralcn8p	259	11	also	also	RB
cord-012418-6ralcn8p	259	12	proteins	protein	NNS
cord-012418-6ralcn8p	259	13	expressed	express	VBN
cord-012418-6ralcn8p	259	14	predominantly	predominantly	RB
cord-012418-6ralcn8p	259	15	in	in	IN
cord-012418-6ralcn8p	259	16	immune	immune	JJ
cord-012418-6ralcn8p	259	17	cells	cell	NNS
cord-012418-6ralcn8p	259	18	.	.	.
cord-012418-6ralcn8p	260	1	In	in	IN
cord-012418-6ralcn8p	260	2	particular	particular	JJ
cord-012418-6ralcn8p	260	3	,	,	,
cord-012418-6ralcn8p	260	4	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	260	5	aiming	aim	VBG
cord-012418-6ralcn8p	260	6	at	at	IN
cord-012418-6ralcn8p	260	7	dampening	dampen	VBG
cord-012418-6ralcn8p	260	8	the	the	DT
cord-012418-6ralcn8p	260	9	activity	activity	NN
cord-012418-6ralcn8p	260	10	of	of	IN
cord-012418-6ralcn8p	260	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	260	12	were	be	VBD
cord-012418-6ralcn8p	260	13	usually	usually	RB
cord-012418-6ralcn8p	260	14	identified	identify	VBN
cord-012418-6ralcn8p	260	15	in	in	IN
cord-012418-6ralcn8p	260	16	macrophages	macrophage	NNS
cord-012418-6ralcn8p	260	17	,	,	,
cord-012418-6ralcn8p	260	18	highlighting	highlight	VBG
cord-012418-6ralcn8p	260	19	the	the	DT
cord-012418-6ralcn8p	260	20	importance	importance	NN
cord-012418-6ralcn8p	260	21	to	to	TO
cord-012418-6ralcn8p	260	22	keep	keep	VB
cord-012418-6ralcn8p	260	23	the	the	DT
cord-012418-6ralcn8p	260	24	response	response	NN
cord-012418-6ralcn8p	260	25	primed	prime	VBN
cord-012418-6ralcn8p	260	26	but	but	CC
cord-012418-6ralcn8p	260	27	low	low	JJ
cord-012418-6ralcn8p	260	28	until	until	IN
cord-012418-6ralcn8p	260	29	the	the	DT
cord-012418-6ralcn8p	260	30	full	full	JJ
cord-012418-6ralcn8p	260	31	activation	activation	NN
cord-012418-6ralcn8p	260	32	becomes	become	VBZ
cord-012418-6ralcn8p	260	33	necessary	necessary	JJ
cord-012418-6ralcn8p	260	34	.	.	.
cord-012418-6ralcn8p	261	1	Since	since	IN
cord-012418-6ralcn8p	261	2	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	261	3	modifications	modification	NNS
cord-012418-6ralcn8p	261	4	of	of	IN
cord-012418-6ralcn8p	261	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	261	6	and	and	CC
cord-012418-6ralcn8p	261	7	especially	especially	RB
cord-012418-6ralcn8p	261	8	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	261	9	and	and	CC
cord-012418-6ralcn8p	261	10	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	261	11	were	be	VBD
cord-012418-6ralcn8p	261	12	reviewed	review	VBN
cord-012418-6ralcn8p	261	13	before	before	IN
cord-012418-6ralcn8p	261	14	[	[	-LRB-
cord-012418-6ralcn8p	261	15	125	125	CD
cord-012418-6ralcn8p	261	16	,	,	,
cord-012418-6ralcn8p	261	17	126	126	CD
cord-012418-6ralcn8p	261	18	]	]	-RRB-
cord-012418-6ralcn8p	261	19	,	,	,
cord-012418-6ralcn8p	261	20	we	-PRON-	PRP
cord-012418-6ralcn8p	261	21	will	will	MD
cord-012418-6ralcn8p	261	22	instead	instead	RB
cord-012418-6ralcn8p	261	23	focus	focus	VB
cord-012418-6ralcn8p	261	24	on	on	IN
cord-012418-6ralcn8p	261	25	how	how	WRB
cord-012418-6ralcn8p	261	26	the	the	DT
cord-012418-6ralcn8p	261	27	host	host	NN
cord-012418-6ralcn8p	261	28	factors	factor	NNS
cord-012418-6ralcn8p	261	29	engage	engage	VBP
cord-012418-6ralcn8p	261	30	in	in	IN
cord-012418-6ralcn8p	261	31	the	the	DT
cord-012418-6ralcn8p	261	32	different	different	JJ
cord-012418-6ralcn8p	261	33	steps	step	NNS
cord-012418-6ralcn8p	261	34	to	to	TO
cord-012418-6ralcn8p	261	35	modulate	modulate	VB
cord-012418-6ralcn8p	261	36	the	the	DT
cord-012418-6ralcn8p	261	37	biologic	biologic	JJ
cord-012418-6ralcn8p	261	38	activity	activity	NN
cord-012418-6ralcn8p	261	39	of	of	IN
cord-012418-6ralcn8p	261	40	IRF3	IRF3	NNP
cord-012418-6ralcn8p	262	1	(	(	-LRB-
cord-012418-6ralcn8p	262	2	Figure	figure	NN
cord-012418-6ralcn8p	262	3	3	3	CD
cord-012418-6ralcn8p	262	4	)	)	-RRB-
cord-012418-6ralcn8p	262	5	.	.	.
cord-012418-6ralcn8p	262	6	 	 	_SP
cord-012418-6ralcn8p	263	1	In	in	IN
cord-012418-6ralcn8p	263	2	addition	addition	NN
cord-012418-6ralcn8p	263	3	to	to	IN
cord-012418-6ralcn8p	263	4	the	the	DT
cord-012418-6ralcn8p	263	5	essential	essential	JJ
cord-012418-6ralcn8p	263	6	steps	step	NNS
cord-012418-6ralcn8p	263	7	of	of	IN
cord-012418-6ralcn8p	263	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	263	9	activation	activation	NN
cord-012418-6ralcn8p	263	10	delineated	delineate	VBN
cord-012418-6ralcn8p	263	11	above	above	RB
cord-012418-6ralcn8p	263	12	,	,	,
cord-012418-6ralcn8p	263	13	various	various	JJ
cord-012418-6ralcn8p	263	14	protein	protein	NN
cord-012418-6ralcn8p	263	15	-	-	HYPH
cord-012418-6ralcn8p	263	16	protein	protein	NN
cord-012418-6ralcn8p	263	17	interactions	interaction	NNS
cord-012418-6ralcn8p	263	18	and	and	CC
cord-012418-6ralcn8p	263	19	additional	additional	JJ
cord-012418-6ralcn8p	263	20	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	263	21	modifications	modification	NNS
cord-012418-6ralcn8p	263	22	were	be	VBD
cord-012418-6ralcn8p	263	23	demonstrated	demonstrate	VBN
cord-012418-6ralcn8p	263	24	to	to	TO
cord-012418-6ralcn8p	263	25	support	support	VB
cord-012418-6ralcn8p	263	26	the	the	DT
cord-012418-6ralcn8p	263	27	biological	biological	JJ
cord-012418-6ralcn8p	263	28	activity	activity	NN
cord-012418-6ralcn8p	263	29	after	after	IN
cord-012418-6ralcn8p	263	30	induction	induction	NN
cord-012418-6ralcn8p	263	31	.	.	.
cord-012418-6ralcn8p	264	1	Before	before	IN
cord-012418-6ralcn8p	264	2	stimulation	stimulation	NN
cord-012418-6ralcn8p	264	3	,	,	,
cord-012418-6ralcn8p	264	4	for	for	IN
cord-012418-6ralcn8p	264	5	example	example	NN
cord-012418-6ralcn8p	264	6	,	,	,
cord-012418-6ralcn8p	264	7	protein	protein	NN
cord-012418-6ralcn8p	264	8	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	264	9	1	1	CD
cord-012418-6ralcn8p	264	10	(	(	-LRB-
cord-012418-6ralcn8p	264	11	PP1	PP1	NNP
cord-012418-6ralcn8p	264	12	)	)	-RRB-
cord-012418-6ralcn8p	264	13	removes	remove	VBZ
cord-012418-6ralcn8p	264	14	the	the	DT
cord-012418-6ralcn8p	264	15	phosphate	phosphate	NN
cord-012418-6ralcn8p	264	16	groups	group	NNS
cord-012418-6ralcn8p	264	17	at	at	IN
cord-012418-6ralcn8p	264	18	S385	S385	NNP
cord-012418-6ralcn8p	264	19	and	and	CC
cord-012418-6ralcn8p	264	20	S396	S396	NNP
cord-012418-6ralcn8p	264	21	in	in	IN
cord-012418-6ralcn8p	264	22	macrophages	macrophage	NNS
cord-012418-6ralcn8p	264	23	and	and	CC
cord-012418-6ralcn8p	264	24	consequently	consequently	RB
cord-012418-6ralcn8p	264	25	attenuates	attenuate	VBZ
cord-012418-6ralcn8p	264	26	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	264	27	production	production	NN
cord-012418-6ralcn8p	264	28	[	[	-LRB-
cord-012418-6ralcn8p	264	29	127	127	CD
cord-012418-6ralcn8p	264	30	]	]	-RRB-
cord-012418-6ralcn8p	264	31	.	.	.
cord-012418-6ralcn8p	265	1	Early	early	RB
cord-012418-6ralcn8p	265	2	after	after	IN
cord-012418-6ralcn8p	265	3	TLR	TLR	NNP
cord-012418-6ralcn8p	265	4	-	-	:
cord-012418-6ralcn8p	265	5	or	or	CC
cord-012418-6ralcn8p	265	6	RLR	RLR	NNP
cord-012418-6ralcn8p	265	7	-	-	HYPH
cord-012418-6ralcn8p	265	8	mediated	mediate	VBN
cord-012418-6ralcn8p	265	9	stimulation	stimulation	NN
cord-012418-6ralcn8p	265	10	,	,	,
cord-012418-6ralcn8p	265	11	however	however	RB
cord-012418-6ralcn8p	265	12	,	,	,
cord-012418-6ralcn8p	265	13	activity	activity	NN
cord-012418-6ralcn8p	265	14	of	of	IN
cord-012418-6ralcn8p	265	15	PP1	PP1	NNP
cord-012418-6ralcn8p	265	16	is	be	VBZ
cord-012418-6ralcn8p	265	17	down	down	RB
cord-012418-6ralcn8p	265	18	-	-	HYPH
cord-012418-6ralcn8p	265	19	regulated	regulate	VBN
cord-012418-6ralcn8p	265	20	to	to	TO
cord-012418-6ralcn8p	265	21	increase	increase	VB
cord-012418-6ralcn8p	265	22	the	the	DT
cord-012418-6ralcn8p	265	23	pool	pool	NN
cord-012418-6ralcn8p	265	24	of	of	IN
cord-012418-6ralcn8p	265	25	active	active	JJ
cord-012418-6ralcn8p	265	26	IRF3	IRF3	NNP
cord-012418-6ralcn8p	265	27	and	and	CC
cord-012418-6ralcn8p	265	28	augment	augment	VB
cord-012418-6ralcn8p	265	29	the	the	DT
cord-012418-6ralcn8p	265	30	immune	immune	JJ
cord-012418-6ralcn8p	265	31	response	response	NN
cord-012418-6ralcn8p	265	32	[	[	-LRB-
cord-012418-6ralcn8p	265	33	127	127	CD
cord-012418-6ralcn8p	265	34	]	]	-RRB-
cord-012418-6ralcn8p	265	35	.	.	.
cord-012418-6ralcn8p	266	1	Also	also	RB
cord-012418-6ralcn8p	266	2	first	first	RB
cord-012418-6ralcn8p	266	3	identified	identify	VBN
cord-012418-6ralcn8p	266	4	in	in	IN
cord-012418-6ralcn8p	266	5	murine	murine	JJ
cord-012418-6ralcn8p	266	6	macrophages	macrophage	NNS
cord-012418-6ralcn8p	266	7	,	,	,
cord-012418-6ralcn8p	266	8	the	the	DT
cord-012418-6ralcn8p	266	9	lysine	lysine	NN
cord-012418-6ralcn8p	266	10	methyltransferase	methyltransferase	NN
cord-012418-6ralcn8p	266	11	nuclear	nuclear	JJ
cord-012418-6ralcn8p	266	12	receptor	receptor	NN
cord-012418-6ralcn8p	266	13	-	-	HYPH
cord-012418-6ralcn8p	266	14	binding	bind	VBG
cord-012418-6ralcn8p	266	15	SET	set	NN
cord-012418-6ralcn8p	266	16	domain	domain	NN
cord-012418-6ralcn8p	266	17	3	3	CD
cord-012418-6ralcn8p	267	1	(	(	-LRB-
cord-012418-6ralcn8p	267	2	NSD3	NSD3	NNP
cord-012418-6ralcn8p	267	3	)	)	-RRB-
cord-012418-6ralcn8p	267	4	targets	target	VBZ
cord-012418-6ralcn8p	267	5	nuclear	nuclear	JJ
cord-012418-6ralcn8p	267	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	267	7	after	after	IN
cord-012418-6ralcn8p	267	8	viral	viral	JJ
cord-012418-6ralcn8p	267	9	stimulation	stimulation	NN
cord-012418-6ralcn8p	267	10	and	and	CC
cord-012418-6ralcn8p	267	11	modifies	modify	VBZ
cord-012418-6ralcn8p	267	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	267	13	by	by	IN
cord-012418-6ralcn8p	267	14	adding	add	VBG
cord-012418-6ralcn8p	267	15	a	a	DT
cord-012418-6ralcn8p	267	16	single	single	JJ
cord-012418-6ralcn8p	267	17	methyl	methyl	NN
cord-012418-6ralcn8p	267	18	group	group	NN
cord-012418-6ralcn8p	267	19	at	at	IN
cord-012418-6ralcn8p	267	20	K366	K366	NNS
cord-012418-6ralcn8p	267	21	[	[	-LRB-
cord-012418-6ralcn8p	267	22	128	128	CD
cord-012418-6ralcn8p	267	23	]	]	-RRB-
cord-012418-6ralcn8p	267	24	.	.	.
cord-012418-6ralcn8p	268	1	This	this	DT
cord-012418-6ralcn8p	268	2	modification	modification	NN
cord-012418-6ralcn8p	268	3	promotes	promote	VBZ
cord-012418-6ralcn8p	268	4	the	the	DT
cord-012418-6ralcn8p	268	5	dissociation	dissociation	NN
cord-012418-6ralcn8p	268	6	of	of	IN
cord-012418-6ralcn8p	268	7	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	268	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	268	9	from	from	IN
cord-012418-6ralcn8p	268	10	an	an	DT
cord-012418-6ralcn8p	268	11	isoform	isoform	NN
cord-012418-6ralcn8p	268	12	of	of	IN
cord-012418-6ralcn8p	268	13	PP1	PP1	NNP
cord-012418-6ralcn8p	268	14	catalytic	catalytic	JJ
cord-012418-6ralcn8p	268	15	subunit	subunit	NN
cord-012418-6ralcn8p	268	16	γ	γ	NN
cord-012418-6ralcn8p	268	17	,	,	,
cord-012418-6ralcn8p	268	18	thereby	thereby	RB
cord-012418-6ralcn8p	268	19	hindering	hinder	VBG
cord-012418-6ralcn8p	268	20	the	the	DT
cord-012418-6ralcn8p	268	21	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	268	22	effect	effect	NN
cord-012418-6ralcn8p	268	23	of	of	IN
cord-012418-6ralcn8p	268	24	PP1	PP1	NNP
cord-012418-6ralcn8p	268	25	and	and	CC
cord-012418-6ralcn8p	268	26	maintaining	maintain	VBG
cord-012418-6ralcn8p	268	27	the	the	DT
cord-012418-6ralcn8p	268	28	activated	activate	VBN
cord-012418-6ralcn8p	268	29	state	state	NN
cord-012418-6ralcn8p	268	30	of	of	IN
cord-012418-6ralcn8p	268	31	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	268	32	IRF3	IRF3	NNP
cord-012418-6ralcn8p	268	33	.	.	.
cord-012418-6ralcn8p	269	1	Similarly	similarly	RB
cord-012418-6ralcn8p	269	2	,	,	,
cord-012418-6ralcn8p	269	3	type	type	NN
cord-012418-6ralcn8p	270	1	I	-PRON-	PRP
cord-012418-6ralcn8p	270	2	IFN	IFN	NNP
cord-012418-6ralcn8p	270	3	up	up	RB
cord-012418-6ralcn8p	270	4	-	-	HYPH
cord-012418-6ralcn8p	270	5	regulates	regulate	VBZ
cord-012418-6ralcn8p	270	6	the	the	DT
cord-012418-6ralcn8p	270	7	expression	expression	NN
cord-012418-6ralcn8p	270	8	of	of	IN
cord-012418-6ralcn8p	270	9	the	the	DT
cord-012418-6ralcn8p	270	10	long	long	JJ
cord-012418-6ralcn8p	270	11	non	non	JJ
cord-012418-6ralcn8p	270	12	-	-	JJ
cord-012418-6ralcn8p	270	13	coding	coding	JJ
cord-012418-6ralcn8p	270	14	RNA	RNA	NNP
cord-012418-6ralcn8p	270	15	lncLrrc55-AS	lncLrrc55-AS	NNP
cord-012418-6ralcn8p	270	16	,	,	,
cord-012418-6ralcn8p	270	17	an	an	DT
cord-012418-6ralcn8p	270	18	antisense	antisense	NN
cord-012418-6ralcn8p	270	19	transcript	transcript	NN
cord-012418-6ralcn8p	270	20	to	to	IN
cord-012418-6ralcn8p	270	21	the	the	DT
cord-012418-6ralcn8p	270	22	gene	gene	NN
cord-012418-6ralcn8p	270	23	of	of	IN
cord-012418-6ralcn8p	270	24	leucine	leucine	NN
cord-012418-6ralcn8p	270	25	-	-	HYPH
cord-012418-6ralcn8p	270	26	rich	rich	JJ
cord-012418-6ralcn8p	270	27	repeat	repeat	NN
cord-012418-6ralcn8p	270	28	-	-	HYPH
cord-012418-6ralcn8p	270	29	containing	contain	VBG
cord-012418-6ralcn8p	270	30	protein	protein	NN
cord-012418-6ralcn8p	270	31	55	55	CD
cord-012418-6ralcn8p	270	32	,	,	,
cord-012418-6ralcn8p	270	33	which	which	WDT
cord-012418-6ralcn8p	270	34	supports	support	VBZ
cord-012418-6ralcn8p	270	35	IRF3	IRF3	NNP
cord-012418-6ralcn8p	270	36	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	270	37	in	in	IN
cord-012418-6ralcn8p	270	38	macrophages	macrophage	NNS
cord-012418-6ralcn8p	270	39	by	by	IN
cord-012418-6ralcn8p	270	40	inhibiting	inhibit	VBG
cord-012418-6ralcn8p	270	41	an	an	DT
cord-012418-6ralcn8p	270	42	inhibitor	inhibitor	NN
cord-012418-6ralcn8p	270	43	[	[	-LRB-
cord-012418-6ralcn8p	270	44	129	129	CD
cord-012418-6ralcn8p	270	45	]	]	-RRB-
cord-012418-6ralcn8p	270	46	.	.	.
cord-012418-6ralcn8p	271	1	In	in	IN
cord-012418-6ralcn8p	271	2	the	the	DT
cord-012418-6ralcn8p	271	3	cytosol	cytosol	NN
cord-012418-6ralcn8p	271	4	,	,	,
cord-012418-6ralcn8p	271	5	lncLrrc55-AS	lnclrrc55-as	XX
cord-012418-6ralcn8p	271	6	associates	associate	NNS
cord-012418-6ralcn8p	271	7	with	with	IN
cord-012418-6ralcn8p	271	8	the	the	DT
cord-012418-6ralcn8p	271	9	protein	protein	NN
cord-012418-6ralcn8p	271	10	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	271	11	methylesterase	methylesterase	NNP
cord-012418-6ralcn8p	271	12	1	1	CD
cord-012418-6ralcn8p	271	13	(	(	-LRB-
cord-012418-6ralcn8p	271	14	PME-1	PME-1	NNP
cord-012418-6ralcn8p	271	15	)	)	-RRB-
cord-012418-6ralcn8p	271	16	,	,	,
cord-012418-6ralcn8p	271	17	which	which	WDT
cord-012418-6ralcn8p	271	18	in	in	IN
cord-012418-6ralcn8p	271	19	turn	turn	NN
cord-012418-6ralcn8p	271	20	promotes	promote	VBZ
cord-012418-6ralcn8p	271	21	the	the	DT
cord-012418-6ralcn8p	271	22	interaction	interaction	NN
cord-012418-6ralcn8p	271	23	of	of	IN
cord-012418-6ralcn8p	271	24	PME-1	PME-1	NNP
cord-012418-6ralcn8p	271	25	and	and	CC
cord-012418-6ralcn8p	271	26	the	the	DT
cord-012418-6ralcn8p	271	27	protein	protein	NN
cord-012418-6ralcn8p	271	28	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	271	29	2A	2a	CD
cord-012418-6ralcn8p	271	30	(	(	-LRB-
cord-012418-6ralcn8p	271	31	PP2A	PP2A	NNP
cord-012418-6ralcn8p	271	32	)	)	-RRB-
cord-012418-6ralcn8p	271	33	.	.	.
cord-012418-6ralcn8p	272	1	PP2A	PP2A	NNP
cord-012418-6ralcn8p	272	2	is	be	VBZ
cord-012418-6ralcn8p	272	3	an	an	DT
cord-012418-6ralcn8p	272	4	inhibitor	inhibitor	NN
cord-012418-6ralcn8p	272	5	of	of	IN
cord-012418-6ralcn8p	272	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	272	7	signalling	signalling	NN
cord-012418-6ralcn8p	272	8	,	,	,
cord-012418-6ralcn8p	272	9	but	but	CC
cord-012418-6ralcn8p	272	10	lncLrrc55-AS	lnclrrc55-as	NN
cord-012418-6ralcn8p	272	11	mediates	mediate	VBZ
cord-012418-6ralcn8p	272	12	its	-PRON-	PRP$
cord-012418-6ralcn8p	272	13	demethylation	demethylation	NN
cord-012418-6ralcn8p	272	14	and	and	CC
cord-012418-6ralcn8p	272	15	inactivation	inactivation	NN
cord-012418-6ralcn8p	272	16	to	to	TO
cord-012418-6ralcn8p	272	17	maintain	maintain	VB
cord-012418-6ralcn8p	272	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	272	19	activity	activity	NN
cord-012418-6ralcn8p	272	20	[	[	-LRB-
cord-012418-6ralcn8p	272	21	129	129	CD
cord-012418-6ralcn8p	272	22	]	]	-RRB-
cord-012418-6ralcn8p	272	23	[	[	-LRB-
cord-012418-6ralcn8p	272	24	130	130	CD
cord-012418-6ralcn8p	272	25	]	]	-RRB-
cord-012418-6ralcn8p	272	26	[	[	-LRB-
cord-012418-6ralcn8p	272	27	131	131	CD
cord-012418-6ralcn8p	272	28	]	]	-RRB-
cord-012418-6ralcn8p	272	29	.	.	.
cord-012418-6ralcn8p	273	1	Additionally	additionally	RB
cord-012418-6ralcn8p	273	2	,	,	,
cord-012418-6ralcn8p	273	3	stability	stability	NN
cord-012418-6ralcn8p	273	4	of	of	IN
cord-012418-6ralcn8p	273	5	the	the	DT
cord-012418-6ralcn8p	273	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	273	7	protein	protein	NN
cord-012418-6ralcn8p	273	8	is	be	VBZ
cord-012418-6ralcn8p	273	9	promoted	promote	VBN
cord-012418-6ralcn8p	273	10	within	within	IN
cord-012418-6ralcn8p	273	11	the	the	DT
cord-012418-6ralcn8p	273	12	loop	loop	NN
cord-012418-6ralcn8p	273	13	of	of	IN
cord-012418-6ralcn8p	273	14	the	the	DT
cord-012418-6ralcn8p	273	15	type	type	NN
cord-012418-6ralcn8p	273	16	I	-PRON-	PRP
cord-012418-6ralcn8p	273	17	IFN	IFN	NNP
cord-012418-6ralcn8p	273	18	response	response	NN
cord-012418-6ralcn8p	273	19	by	by	IN
cord-012418-6ralcn8p	273	20	covalent	covalent	JJ
cord-012418-6ralcn8p	273	21	conjugation	conjugation	NN
cord-012418-6ralcn8p	273	22	of	of	IN
cord-012418-6ralcn8p	273	23	newly	newly	RB
cord-012418-6ralcn8p	273	24	synthesised	synthesise	VBN
cord-012418-6ralcn8p	273	25	ISG15	isg15	NN
cord-012418-6ralcn8p	273	26	to	to	IN
cord-012418-6ralcn8p	273	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	273	28	on	on	IN
cord-012418-6ralcn8p	273	29	K193	K193	NNP
cord-012418-6ralcn8p	273	30	,	,	,
cord-012418-6ralcn8p	273	31	K360	K360	NNP
cord-012418-6ralcn8p	273	32	or	or	CC
cord-012418-6ralcn8p	273	33	K366	K366	NNS
cord-012418-6ralcn8p	273	34	mediated	mediate	VBN
cord-012418-6ralcn8p	273	35	by	by	IN
cord-012418-6ralcn8p	273	36	Herc5	Herc5	NNS
cord-012418-6ralcn8p	273	37	(	(	-LRB-
cord-012418-6ralcn8p	273	38	HECT	HECT	NNP
cord-012418-6ralcn8p	273	39	and	and	CC
cord-012418-6ralcn8p	273	40	RLD	RLD	NNP
cord-012418-6ralcn8p	273	41	domain	domain	NN
cord-012418-6ralcn8p	273	42	-	-	HYPH
cord-012418-6ralcn8p	273	43	containing	contain	VBG
cord-012418-6ralcn8p	273	44	E3	E3	NNP
cord-012418-6ralcn8p	273	45	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	273	46	protein	protein	NN
cord-012418-6ralcn8p	273	47	ligase	ligase	NN
cord-012418-6ralcn8p	273	48	5	5	CD
cord-012418-6ralcn8p	273	49	)	)	-RRB-
cord-012418-6ralcn8p	274	1	[	[	-LRB-
cord-012418-6ralcn8p	274	2	132	132	CD
cord-012418-6ralcn8p	274	3	,	,	,
cord-012418-6ralcn8p	274	4	133	133	CD
cord-012418-6ralcn8p	274	5	]	]	-RRB-
cord-012418-6ralcn8p	274	6	.	.	.
cord-012418-6ralcn8p	275	1	This	this	DT
cord-012418-6ralcn8p	275	2	modification	modification	NN
cord-012418-6ralcn8p	275	3	,	,	,
cord-012418-6ralcn8p	275	4	termed	term	VBN
cord-012418-6ralcn8p	275	5	ISGylation	isgylation	NN
cord-012418-6ralcn8p	275	6	,	,	,
cord-012418-6ralcn8p	275	7	disturbs	disturb	VBZ
cord-012418-6ralcn8p	275	8	the	the	DT
cord-012418-6ralcn8p	275	9	interaction	interaction	NN
cord-012418-6ralcn8p	275	10	between	between	IN
cord-012418-6ralcn8p	275	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	275	12	and	and	CC
cord-012418-6ralcn8p	275	13	peptidyl	peptidyl	NNP
cord-012418-6ralcn8p	275	14	-	-	HYPH
cord-012418-6ralcn8p	275	15	prolyl	prolyl	JJ
cord-012418-6ralcn8p	275	16	isomerase	isomerase	NN
cord-012418-6ralcn8p	275	17	1	1	CD
cord-012418-6ralcn8p	275	18	(	(	-LRB-
cord-012418-6ralcn8p	275	19	Pin1	Pin1	NNP
cord-012418-6ralcn8p	275	20	)	)	-RRB-
cord-012418-6ralcn8p	275	21	,	,	,
cord-012418-6ralcn8p	275	22	delays	delay	VBZ
cord-012418-6ralcn8p	275	23	the	the	DT
cord-012418-6ralcn8p	275	24	proteolytic	proteolytic	JJ
cord-012418-6ralcn8p	275	25	degradation	degradation	NN
cord-012418-6ralcn8p	275	26	of	of	IN
cord-012418-6ralcn8p	275	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	275	28	and	and	CC
cord-012418-6ralcn8p	275	29	in	in	IN
cord-012418-6ralcn8p	275	30	this	this	DT
cord-012418-6ralcn8p	275	31	way	way	NN
cord-012418-6ralcn8p	275	32	prolongs	prolong	VBZ
cord-012418-6ralcn8p	275	33	the	the	DT
cord-012418-6ralcn8p	275	34	immune	immune	JJ
cord-012418-6ralcn8p	275	35	response	response	NN
cord-012418-6ralcn8p	275	36	[	[	-LRB-
cord-012418-6ralcn8p	275	37	132	132	CD
cord-012418-6ralcn8p	275	38	]	]	-RRB-
cord-012418-6ralcn8p	275	39	[	[	-LRB-
cord-012418-6ralcn8p	275	40	133	133	CD
cord-012418-6ralcn8p	275	41	]	]	-RRB-
cord-012418-6ralcn8p	275	42	[	[	-LRB-
cord-012418-6ralcn8p	275	43	134	134	CD
cord-012418-6ralcn8p	275	44	]	]	-RRB-
cord-012418-6ralcn8p	275	45	.	.	.
cord-012418-6ralcn8p	276	1	The	the	DT
cord-012418-6ralcn8p	276	2	dual	dual	JJ
cord-012418-6ralcn8p	276	3	use	use	NN
cord-012418-6ralcn8p	276	4	of	of	IN
cord-012418-6ralcn8p	276	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	276	6	K366	K366	NNS
cord-012418-6ralcn8p	276	7	for	for	IN
cord-012418-6ralcn8p	276	8	methylation	methylation	NN
cord-012418-6ralcn8p	276	9	by	by	IN
cord-012418-6ralcn8p	276	10	NSD3	NSD3	NNP
cord-012418-6ralcn8p	276	11	versus	versus	IN
cord-012418-6ralcn8p	276	12	ISGylation	ISGylation	NNP
cord-012418-6ralcn8p	276	13	by	by	IN
cord-012418-6ralcn8p	276	14	Herc5	Herc5	NNP
cord-012418-6ralcn8p	276	15	,	,	,
cord-012418-6ralcn8p	276	16	both	both	DT
cord-012418-6ralcn8p	276	17	of	of	IN
cord-012418-6ralcn8p	276	18	which	which	WDT
cord-012418-6ralcn8p	276	19	contribute	contribute	VBP
cord-012418-6ralcn8p	276	20	to	to	IN
cord-012418-6ralcn8p	276	21	protein	protein	NN
cord-012418-6ralcn8p	276	22	stability	stability	NN
cord-012418-6ralcn8p	276	23	,	,	,
cord-012418-6ralcn8p	276	24	hints	hint	VBZ
cord-012418-6ralcn8p	276	25	at	at	IN
cord-012418-6ralcn8p	276	26	a	a	DT
cord-012418-6ralcn8p	276	27	complex	complex	JJ
cord-012418-6ralcn8p	276	28	network	network	NN
cord-012418-6ralcn8p	276	29	that	that	WDT
cord-012418-6ralcn8p	276	30	also	also	RB
cord-012418-6ralcn8p	276	31	modulates	modulate	VBZ
cord-012418-6ralcn8p	276	32	the	the	DT
cord-012418-6ralcn8p	276	33	modulators	modulator	NNS
cord-012418-6ralcn8p	276	34	.	.	.
cord-012418-6ralcn8p	277	1	While	while	IN
cord-012418-6ralcn8p	277	2	inactive	inactive	JJ
cord-012418-6ralcn8p	277	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	277	4	already	already	RB
cord-012418-6ralcn8p	277	5	shuttles	shuttle	VBZ
cord-012418-6ralcn8p	277	6	between	between	IN
cord-012418-6ralcn8p	277	7	the	the	DT
cord-012418-6ralcn8p	277	8	cytosol	cytosol	NN
cord-012418-6ralcn8p	277	9	and	and	CC
cord-012418-6ralcn8p	277	10	nucleus	nucleus	NN
cord-012418-6ralcn8p	277	11	in	in	IN
cord-012418-6ralcn8p	277	12	latent	latent	JJ
cord-012418-6ralcn8p	277	13	conditions	condition	NNS
cord-012418-6ralcn8p	277	14	,	,	,
cord-012418-6ralcn8p	277	15	the	the	DT
cord-012418-6ralcn8p	277	16	translocation	translocation	NN
cord-012418-6ralcn8p	277	17	becomes	become	VBZ
cord-012418-6ralcn8p	277	18	crucial	crucial	JJ
cord-012418-6ralcn8p	277	19	after	after	IN
cord-012418-6ralcn8p	277	20	its	-PRON-	PRP$
cord-012418-6ralcn8p	277	21	activation	activation	NN
cord-012418-6ralcn8p	277	22	in	in	IN
cord-012418-6ralcn8p	277	23	order	order	NN
cord-012418-6ralcn8p	277	24	to	to	TO
cord-012418-6ralcn8p	277	25	exercise	exercise	VB
cord-012418-6ralcn8p	277	26	the	the	DT
cord-012418-6ralcn8p	277	27	trans	trans	JJ
cord-012418-6ralcn8p	277	28	-	-	JJ
cord-012418-6ralcn8p	277	29	activation	activation	JJ
cord-012418-6ralcn8p	277	30	activity	activity	NN
cord-012418-6ralcn8p	277	31	.	.	.
cord-012418-6ralcn8p	278	1	Just	just	RB
cord-012418-6ralcn8p	278	2	recently	recently	RB
cord-012418-6ralcn8p	278	3	,	,	,
cord-012418-6ralcn8p	278	4	Cai	Cai	NNP
cord-012418-6ralcn8p	278	5	and	and	CC
cord-012418-6ralcn8p	278	6	colleagues	colleague	NNS
cord-012418-6ralcn8p	278	7	reported	report	VBD
cord-012418-6ralcn8p	278	8	that	that	IN
cord-012418-6ralcn8p	278	9	the	the	DT
cord-012418-6ralcn8p	278	10	ubiquitin	ubiquitin	JJ
cord-012418-6ralcn8p	278	11	specific	specific	JJ
cord-012418-6ralcn8p	278	12	peptidase	peptidase	NN
cord-012418-6ralcn8p	278	13	22	22	CD
cord-012418-6ralcn8p	278	14	(	(	-LRB-
cord-012418-6ralcn8p	278	15	USP22	USP22	NNP
cord-012418-6ralcn8p	278	16	)	)	-RRB-
cord-012418-6ralcn8p	278	17	promotes	promote	VBZ
cord-012418-6ralcn8p	278	18	the	the	DT
cord-012418-6ralcn8p	278	19	antiviral	antiviral	JJ
cord-012418-6ralcn8p	278	20	response	response	NN
cord-012418-6ralcn8p	278	21	from	from	IN
cord-012418-6ralcn8p	278	22	the	the	DT
cord-012418-6ralcn8p	278	23	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	278	24	by	by	IN
cord-012418-6ralcn8p	278	25	deubiquitinating	deubiquitinate	VBG
cord-012418-6ralcn8p	278	26	importin	importin	NNP
cord-012418-6ralcn8p	279	1	KPNA2	KPNA2	NNP
cord-012418-6ralcn8p	279	2	[	[	-LRB-
cord-012418-6ralcn8p	279	3	60	60	CD
cord-012418-6ralcn8p	279	4	]	]	-RRB-
cord-012418-6ralcn8p	279	5	.	.	.
cord-012418-6ralcn8p	280	1	After	after	IN
cord-012418-6ralcn8p	280	2	viral	viral	JJ
cord-012418-6ralcn8p	280	3	infection	infection	NN
cord-012418-6ralcn8p	280	4	,	,	,
cord-012418-6ralcn8p	280	5	KPNA2	KPNA2	NNP
cord-012418-6ralcn8p	280	6	associates	associate	NNS
cord-012418-6ralcn8p	280	7	with	with	IN
cord-012418-6ralcn8p	280	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	280	9	for	for	IN
cord-012418-6ralcn8p	280	10	nuclear	nuclear	JJ
cord-012418-6ralcn8p	280	11	import	import	NN
cord-012418-6ralcn8p	280	12	,	,	,
cord-012418-6ralcn8p	280	13	and	and	CC
cord-012418-6ralcn8p	280	14	USP22	USP22	NNP
cord-012418-6ralcn8p	280	15	promotes	promote	VBZ
cord-012418-6ralcn8p	280	16	this	this	DT
cord-012418-6ralcn8p	280	17	critical	critical	JJ
cord-012418-6ralcn8p	280	18	step	step	NN
cord-012418-6ralcn8p	280	19	by	by	IN
cord-012418-6ralcn8p	280	20	stabilizing	stabilize	VBG
cord-012418-6ralcn8p	280	21	KPNA2	KPNA2	NNP
cord-012418-6ralcn8p	280	22	.	.	.
cord-012418-6ralcn8p	281	1	Importin	Importin	NNP
cord-012418-6ralcn8p	281	2	-	-	HYPH
cord-012418-6ralcn8p	281	3	mediated	mediate	VBN
cord-012418-6ralcn8p	281	4	translocation	translocation	NN
cord-012418-6ralcn8p	281	5	is	be	VBZ
cord-012418-6ralcn8p	281	6	additionally	additionally	RB
cord-012418-6ralcn8p	281	7	regulated	regulate	VBN
cord-012418-6ralcn8p	281	8	by	by	IN
cord-012418-6ralcn8p	281	9	the	the	DT
cord-012418-6ralcn8p	281	10	widely	widely	RB
cord-012418-6ralcn8p	281	11	expressed	express	VBN
cord-012418-6ralcn8p	281	12	transcription	transcription	NN
cord-012418-6ralcn8p	281	13	regulators	regulator	NNS
cord-012418-6ralcn8p	281	14	Yes	yes	RB
cord-012418-6ralcn8p	281	15	associated	associate	VBD
cord-012418-6ralcn8p	281	16	protein	protein	NN
cord-012418-6ralcn8p	281	17	1	1	CD
cord-012418-6ralcn8p	281	18	(	(	-LRB-
cord-012418-6ralcn8p	281	19	YAP1	YAP1	NNP
cord-012418-6ralcn8p	281	20	)	)	-RRB-
cord-012418-6ralcn8p	281	21	,	,	,
cord-012418-6ralcn8p	281	22	YAP2	YAP2	NNP
cord-012418-6ralcn8p	281	23	and	and	CC
cord-012418-6ralcn8p	281	24	YAP4	YAP4	NNP
cord-012418-6ralcn8p	281	25	:	:	:
cord-012418-6ralcn8p	282	1	YAP1/2/4	YAP1/2/4	NNS
cord-012418-6ralcn8p	282	2	associate	associate	JJ
cord-012418-6ralcn8p	282	3	with	with	IN
cord-012418-6ralcn8p	282	4	latent	latent	NN
cord-012418-6ralcn8p	282	5	as	as	RB
cord-012418-6ralcn8p	282	6	well	well	RB
cord-012418-6ralcn8p	282	7	as	as	IN
cord-012418-6ralcn8p	282	8	activated	activate	VBN
cord-012418-6ralcn8p	282	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	282	10	and	and	CC
cord-012418-6ralcn8p	282	11	block	block	VB
cord-012418-6ralcn8p	282	12	further	further	JJ
cord-012418-6ralcn8p	282	13	interactions	interaction	NNS
cord-012418-6ralcn8p	282	14	required	require	VBN
cord-012418-6ralcn8p	282	15	for	for	IN
cord-012418-6ralcn8p	282	16	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	282	17	or	or	CC
cord-012418-6ralcn8p	282	18	nuclear	nuclear	JJ
cord-012418-6ralcn8p	282	19	import	import	NN
cord-012418-6ralcn8p	282	20	[	[	-LRB-
cord-012418-6ralcn8p	282	21	135	135	CD
cord-012418-6ralcn8p	282	22	]	]	-RRB-
cord-012418-6ralcn8p	282	23	.	.	.
cord-012418-6ralcn8p	283	1	After	after	IN
cord-012418-6ralcn8p	283	2	virus	virus	NN
cord-012418-6ralcn8p	283	3	infection	infection	NN
cord-012418-6ralcn8p	283	4	,	,	,
cord-012418-6ralcn8p	283	5	however	however	RB
cord-012418-6ralcn8p	283	6	,	,	,
cord-012418-6ralcn8p	283	7	activated	activate	VBN
cord-012418-6ralcn8p	283	8	IKKε	IKKε	NNPS
cord-012418-6ralcn8p	283	9	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	283	10	a	a	DT
cord-012418-6ralcn8p	283	11	conserved	conserved	JJ
cord-012418-6ralcn8p	283	12	motif	motif	NN
cord-012418-6ralcn8p	283	13	of	of	IN
cord-012418-6ralcn8p	283	14	the	the	DT
cord-012418-6ralcn8p	283	15	YAPs	yap	NNS
cord-012418-6ralcn8p	283	16	,	,	,
cord-012418-6ralcn8p	283	17	which	which	WDT
cord-012418-6ralcn8p	283	18	triggers	trigger	VBZ
cord-012418-6ralcn8p	283	19	their	-PRON-	PRP$
cord-012418-6ralcn8p	283	20	lysosomal	lysosomal	JJ
cord-012418-6ralcn8p	283	21	degradation	degradation	NN
cord-012418-6ralcn8p	283	22	and	and	CC
cord-012418-6ralcn8p	283	23	reliefs	relief	NNS
cord-012418-6ralcn8p	283	24	the	the	DT
cord-012418-6ralcn8p	283	25	YAP	YAP	NNP
cord-012418-6ralcn8p	283	26	-	-	HYPH
cord-012418-6ralcn8p	283	27	mediated	mediate	VBN
cord-012418-6ralcn8p	283	28	inhibition	inhibition	NN
cord-012418-6ralcn8p	283	29	.	.	.
cord-012418-6ralcn8p	284	1	Further	further	RB
cord-012418-6ralcn8p	284	2	,	,	,
cord-012418-6ralcn8p	284	3	an	an	DT
cord-012418-6ralcn8p	284	4	additional	additional	JJ
cord-012418-6ralcn8p	284	5	phosphate	phosphate	NN
cord-012418-6ralcn8p	284	6	group	group	NN
cord-012418-6ralcn8p	284	7	within	within	IN
cord-012418-6ralcn8p	284	8	the	the	DT
cord-012418-6ralcn8p	284	9	DBD	DBD	NNP
cord-012418-6ralcn8p	284	10	of	of	IN
cord-012418-6ralcn8p	284	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	284	12	at	at	IN
cord-012418-6ralcn8p	284	13	S97	S97	NNP
cord-012418-6ralcn8p	284	14	is	be	VBZ
cord-012418-6ralcn8p	284	15	important	important	JJ
cord-012418-6ralcn8p	284	16	for	for	IN
cord-012418-6ralcn8p	284	17	the	the	DT
cord-012418-6ralcn8p	284	18	nuclear	nuclear	JJ
cord-012418-6ralcn8p	284	19	translocation	translocation	NN
cord-012418-6ralcn8p	284	20	after	after	IN
cord-012418-6ralcn8p	284	21	viral	viral	JJ
cord-012418-6ralcn8p	284	22	stimulation	stimulation	NN
cord-012418-6ralcn8p	284	23	[	[	-LRB-
cord-012418-6ralcn8p	284	24	136	136	CD
cord-012418-6ralcn8p	284	25	]	]	-RRB-
cord-012418-6ralcn8p	284	26	.	.	.
cord-012418-6ralcn8p	285	1	This	this	DT
cord-012418-6ralcn8p	285	2	modification	modification	NN
cord-012418-6ralcn8p	285	3	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	285	4	the	the	DT
cord-012418-6ralcn8p	285	5	nuclear	nuclear	JJ
cord-012418-6ralcn8p	285	6	import	import	NN
cord-012418-6ralcn8p	285	7	,	,	,
cord-012418-6ralcn8p	285	8	and	and	CC
cord-012418-6ralcn8p	285	9	mass	mass	NN
cord-012418-6ralcn8p	285	10	spectrometry	spectrometry	NN
cord-012418-6ralcn8p	285	11	revealed	reveal	VBD
cord-012418-6ralcn8p	285	12	that	that	IN
cord-012418-6ralcn8p	285	13	about	about	RB
cord-012418-6ralcn8p	285	14	a	a	DT
cord-012418-6ralcn8p	285	15	fifth	fifth	JJ
cord-012418-6ralcn8p	285	16	(	(	-LRB-
cord-012418-6ralcn8p	285	17	18.2	18.2	CD
cord-012418-6ralcn8p	285	18	%	%	NN
cord-012418-6ralcn8p	285	19	)	)	-RRB-
cord-012418-6ralcn8p	285	20	of	of	IN
cord-012418-6ralcn8p	285	21	IRF3	IRF3	NNP
cord-012418-6ralcn8p	285	22	molecules	molecule	NNS
cord-012418-6ralcn8p	285	23	carry	carry	VBP
cord-012418-6ralcn8p	285	24	it	-PRON-	PRP
cord-012418-6ralcn8p	285	25	at	at	IN
cord-012418-6ralcn8p	285	26	latent	latent	JJ
cord-012418-6ralcn8p	285	27	conditions	condition	NNS
cord-012418-6ralcn8p	285	28	when	when	WRB
cord-012418-6ralcn8p	285	29	exogenously	exogenously	RB
cord-012418-6ralcn8p	285	30	expressed	express	VBN
cord-012418-6ralcn8p	285	31	in	in	IN
cord-012418-6ralcn8p	285	32	HEK293	HEK293	NNP
cord-012418-6ralcn8p	285	33	.	.	.
cord-012418-6ralcn8p	286	1	Upon	upon	IN
cord-012418-6ralcn8p	286	2	viral	viral	JJ
cord-012418-6ralcn8p	286	3	stimulation	stimulation	NN
cord-012418-6ralcn8p	286	4	,	,	,
cord-012418-6ralcn8p	286	5	the	the	DT
cord-012418-6ralcn8p	286	6	dual	dual	JJ
cord-012418-6ralcn8p	286	7	-	-	HYPH
cord-012418-6ralcn8p	286	8	specificity	specificity	NN
cord-012418-6ralcn8p	286	9	protein	protein	NN
cord-012418-6ralcn8p	286	10	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	286	11	and	and	CC
cord-012418-6ralcn8p	286	12	tensin	tensin	NNP
cord-012418-6ralcn8p	286	13	homolog	homolog	NN
cord-012418-6ralcn8p	286	14	(	(	-LRB-
cord-012418-6ralcn8p	286	15	PTEN	PTEN	NNP
cord-012418-6ralcn8p	286	16	)	)	-RRB-
cord-012418-6ralcn8p	286	17	removes	remove	VBZ
cord-012418-6ralcn8p	286	18	this	this	DT
cord-012418-6ralcn8p	286	19	phosphate	phosphate	NN
cord-012418-6ralcn8p	286	20	group	group	NN
cord-012418-6ralcn8p	286	21	and	and	CC
cord-012418-6ralcn8p	286	22	consequently	consequently	RB
cord-012418-6ralcn8p	286	23	the	the	DT
cord-012418-6ralcn8p	286	24	negative	negative	JJ
cord-012418-6ralcn8p	286	25	regulation	regulation	NN
cord-012418-6ralcn8p	286	26	of	of	IN
cord-012418-6ralcn8p	286	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	286	28	[	[	-LRB-
cord-012418-6ralcn8p	286	29	136	136	CD
cord-012418-6ralcn8p	286	30	]	]	-RRB-
cord-012418-6ralcn8p	286	31	.	.	.
cord-012418-6ralcn8p	287	1	Finally	finally	RB
cord-012418-6ralcn8p	287	2	,	,	,
cord-012418-6ralcn8p	287	3	to	to	TO
cord-012418-6ralcn8p	287	4	keep	keep	VB
cord-012418-6ralcn8p	287	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	287	6	in	in	IN
cord-012418-6ralcn8p	287	7	the	the	DT
cord-012418-6ralcn8p	287	8	nucleus	nucleus	NN
cord-012418-6ralcn8p	287	9	,	,	,
cord-012418-6ralcn8p	287	10	DNA	DNA	NNP
cord-012418-6ralcn8p	287	11	-	-	HYPH
cord-012418-6ralcn8p	287	12	PK	PK	NNP
cord-012418-6ralcn8p	287	13	is	be	VBZ
cord-012418-6ralcn8p	287	14	activated	activate	VBN
cord-012418-6ralcn8p	287	15	in	in	IN
cord-012418-6ralcn8p	287	16	response	response	NN
cord-012418-6ralcn8p	287	17	to	to	IN
cord-012418-6ralcn8p	287	18	virus	virus	NN
cord-012418-6ralcn8p	287	19	infection	infection	NN
cord-012418-6ralcn8p	287	20	and	and	CC
cord-012418-6ralcn8p	287	21	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	287	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	287	23	at	at	IN
cord-012418-6ralcn8p	287	24	T135	t135	CD
cord-012418-6ralcn8p	287	25	[	[	-LRB-
cord-012418-6ralcn8p	287	26	137	137	CD
cord-012418-6ralcn8p	287	27	]	]	-RRB-
cord-012418-6ralcn8p	287	28	.	.	.
cord-012418-6ralcn8p	288	1	This	this	DT
cord-012418-6ralcn8p	288	2	phosphate	phosphate	NN
cord-012418-6ralcn8p	288	3	moiety	moiety	NN
cord-012418-6ralcn8p	288	4	mediates	mediate	VBZ
cord-012418-6ralcn8p	288	5	the	the	DT
cord-012418-6ralcn8p	288	6	nuclear	nuclear	JJ
cord-012418-6ralcn8p	288	7	retention	retention	NN
cord-012418-6ralcn8p	288	8	and	and	CC
cord-012418-6ralcn8p	288	9	delays	delay	NNS
cord-012418-6ralcn8p	288	10	proteolysis	proteolysis	NN
cord-012418-6ralcn8p	288	11	of	of	IN
cord-012418-6ralcn8p	288	12	the	the	DT
cord-012418-6ralcn8p	288	13	active	active	JJ
cord-012418-6ralcn8p	288	14	transcription	transcription	NN
cord-012418-6ralcn8p	288	15	factor	factor	NN
cord-012418-6ralcn8p	288	16	,	,	,
cord-012418-6ralcn8p	288	17	thereby	thereby	RB
cord-012418-6ralcn8p	288	18	prolonging	prolong	VBG
cord-012418-6ralcn8p	288	19	the	the	DT
cord-012418-6ralcn8p	288	20	IRF3-driven	IRF3-driven	NNP
cord-012418-6ralcn8p	288	21	response	response	NN
cord-012418-6ralcn8p	288	22	.	.	.
cord-012418-6ralcn8p	289	1	The	the	DT
cord-012418-6ralcn8p	289	2	association	association	NN
cord-012418-6ralcn8p	289	3	of	of	IN
cord-012418-6ralcn8p	289	4	CBP	CBP	NNP
cord-012418-6ralcn8p	289	5	and	and	CC
cord-012418-6ralcn8p	289	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	289	7	in	in	IN
cord-012418-6ralcn8p	289	8	the	the	DT
cord-012418-6ralcn8p	289	9	nucleus	nucleus	NN
cord-012418-6ralcn8p	289	10	is	be	VBZ
cord-012418-6ralcn8p	289	11	supported	support	VBN
cord-012418-6ralcn8p	289	12	by	by	IN
cord-012418-6ralcn8p	289	13	the	the	DT
cord-012418-6ralcn8p	289	14	constitutively	constitutively	RB
cord-012418-6ralcn8p	289	15	active	active	JJ
cord-012418-6ralcn8p	289	16	enzyme	enzyme	NN
cord-012418-6ralcn8p	289	17	glutaredoxin-1	glutaredoxin-1	NN
cord-012418-6ralcn8p	289	18	(	(	-LRB-
cord-012418-6ralcn8p	289	19	GLRX	GLRX	NNP
cord-012418-6ralcn8p	289	20	or	or	CC
cord-012418-6ralcn8p	289	21	GRX1	GRX1	NNP
cord-012418-6ralcn8p	289	22	)	)	-RRB-
cord-012418-6ralcn8p	289	23	,	,	,
cord-012418-6ralcn8p	289	24	which	which	WDT
cord-012418-6ralcn8p	289	25	acts	act	VBZ
cord-012418-6ralcn8p	289	26	in	in	IN
cord-012418-6ralcn8p	289	27	the	the	DT
cord-012418-6ralcn8p	289	28	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	289	29	[	[	-LRB-
cord-012418-6ralcn8p	289	30	138	138	CD
cord-012418-6ralcn8p	289	31	]	]	-RRB-
cord-012418-6ralcn8p	289	32	.	.	.
cord-012418-6ralcn8p	290	1	In	in	IN
cord-012418-6ralcn8p	290	2	resting	rest	VBG
cord-012418-6ralcn8p	290	3	cells	cell	NNS
cord-012418-6ralcn8p	290	4	,	,	,
cord-012418-6ralcn8p	290	5	inactive	inactive	JJ
cord-012418-6ralcn8p	290	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	290	7	is	be	VBZ
cord-012418-6ralcn8p	290	8	S	S	NNP
cord-012418-6ralcn8p	290	9	-	-	HYPH
cord-012418-6ralcn8p	290	10	glutathionylated	glutathionylate	VBN
cord-012418-6ralcn8p	290	11	and	and	CC
cord-012418-6ralcn8p	290	12	this	this	DT
cord-012418-6ralcn8p	290	13	modification	modification	NN
cord-012418-6ralcn8p	290	14	would	would	MD
cord-012418-6ralcn8p	290	15	impede	impede	VB
cord-012418-6ralcn8p	290	16	the	the	DT
cord-012418-6ralcn8p	290	17	essential	essential	JJ
cord-012418-6ralcn8p	290	18	interaction	interaction	NN
cord-012418-6ralcn8p	290	19	of	of	IN
cord-012418-6ralcn8p	290	20	IRF3	IRF3	NNP
cord-012418-6ralcn8p	290	21	and	and	CC
cord-012418-6ralcn8p	290	22	CBP	CBP	NNP
cord-012418-6ralcn8p	290	23	/	/	SYM
cord-012418-6ralcn8p	290	24	p300	p300	NNP
cord-012418-6ralcn8p	290	25	.	.	.
cord-012418-6ralcn8p	291	1	However	however	RB
cord-012418-6ralcn8p	291	2	,	,	,
cord-012418-6ralcn8p	291	3	GLRX	GLRX	NNP
cord-012418-6ralcn8p	291	4	removes	remove	VBZ
cord-012418-6ralcn8p	291	5	this	this	DT
cord-012418-6ralcn8p	291	6	modification	modification	NN
cord-012418-6ralcn8p	291	7	after	after	IN
cord-012418-6ralcn8p	291	8	infection	infection	NN
cord-012418-6ralcn8p	291	9	and	and	CC
cord-012418-6ralcn8p	291	10	thus	thus	RB
cord-012418-6ralcn8p	291	11	supports	support	VBZ
cord-012418-6ralcn8p	291	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	291	13	activity	activity	NN
cord-012418-6ralcn8p	291	14	.	.	.
cord-012418-6ralcn8p	292	1	While	while	IN
cord-012418-6ralcn8p	292	2	the	the	DT
cord-012418-6ralcn8p	292	3	deglutathionylation	deglutathionylation	NN
cord-012418-6ralcn8p	292	4	of	of	IN
cord-012418-6ralcn8p	292	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	292	6	is	be	VBZ
cord-012418-6ralcn8p	292	7	independent	independent	JJ
cord-012418-6ralcn8p	292	8	of	of	IN
cord-012418-6ralcn8p	292	9	its	-PRON-	PRP$
cord-012418-6ralcn8p	292	10	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	292	11	or	or	CC
cord-012418-6ralcn8p	292	12	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	292	13	state	state	NN
cord-012418-6ralcn8p	292	14	,	,	,
cord-012418-6ralcn8p	292	15	the	the	DT
cord-012418-6ralcn8p	292	16	accompanying	accompany	VBG
cord-012418-6ralcn8p	292	17	structural	structural	JJ
cord-012418-6ralcn8p	292	18	changes	change	NNS
cord-012418-6ralcn8p	292	19	could	could	MD
cord-012418-6ralcn8p	292	20	be	be	VB
cord-012418-6ralcn8p	292	21	involved	involve	VBN
cord-012418-6ralcn8p	292	22	in	in	IN
cord-012418-6ralcn8p	292	23	the	the	DT
cord-012418-6ralcn8p	292	24	recruitment	recruitment	NN
cord-012418-6ralcn8p	292	25	of	of	IN
cord-012418-6ralcn8p	292	26	GLRX	GLRX	NNP
cord-012418-6ralcn8p	292	27	to	to	TO
cord-012418-6ralcn8p	292	28	remove	remove	VB
cord-012418-6ralcn8p	292	29	the	the	DT
cord-012418-6ralcn8p	292	30	modification	modification	NN
cord-012418-6ralcn8p	292	31	after	after	IN
cord-012418-6ralcn8p	292	32	initial	initial	JJ
cord-012418-6ralcn8p	292	33	activation	activation	NN
cord-012418-6ralcn8p	292	34	events	event	NNS
cord-012418-6ralcn8p	292	35	[	[	-LRB-
cord-012418-6ralcn8p	292	36	138	138	CD
cord-012418-6ralcn8p	292	37	]	]	-RRB-
cord-012418-6ralcn8p	292	38	.	.	.
cord-012418-6ralcn8p	293	1	Within	within	IN
cord-012418-6ralcn8p	293	2	the	the	DT
cord-012418-6ralcn8p	293	3	nucleus	nucleus	NN
cord-012418-6ralcn8p	293	4	,	,	,
cord-012418-6ralcn8p	293	5	the	the	DT
cord-012418-6ralcn8p	293	6	interaction	interaction	NN
cord-012418-6ralcn8p	293	7	of	of	IN
cord-012418-6ralcn8p	293	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	293	9	and	and	CC
cord-012418-6ralcn8p	293	10	CBP	CBP	NNP
cord-012418-6ralcn8p	293	11	is	be	VBZ
cord-012418-6ralcn8p	293	12	further	far	RBR
cord-012418-6ralcn8p	293	13	promoted	promote	VBN
cord-012418-6ralcn8p	293	14	by	by	IN
cord-012418-6ralcn8p	293	15	a	a	DT
cord-012418-6ralcn8p	293	16	ubiquitously	ubiquitously	RB
cord-012418-6ralcn8p	293	17	expressed	express	VBN
cord-012418-6ralcn8p	293	18	subunit	subunit	NN
cord-012418-6ralcn8p	293	19	of	of	IN
cord-012418-6ralcn8p	293	20	the	the	DT
cord-012418-6ralcn8p	293	21	endosomal	endosomal	NNP
cord-012418-6ralcn8p	293	22	sorting	sort	VBG
cord-012418-6ralcn8p	293	23	complex	complex	NN
cord-012418-6ralcn8p	293	24	required	require	VBN
cord-012418-6ralcn8p	293	25	for	for	IN
cord-012418-6ralcn8p	293	26	Viruses	virus	NNS
cord-012418-6ralcn8p	293	27	2020	2020	CD
cord-012418-6ralcn8p	293	28	,	,	,
cord-012418-6ralcn8p	293	29	12	12	CD
cord-012418-6ralcn8p	293	30	,	,	,
cord-012418-6ralcn8p	293	31	733	733	CD
cord-012418-6ralcn8p	293	32	13	13	CD
cord-012418-6ralcn8p	293	33	of	of	IN
cord-012418-6ralcn8p	293	34	33	33	CD
cord-012418-6ralcn8p	293	35	transport	transport	NN
cord-012418-6ralcn8p	293	36	(	(	-LRB-
cord-012418-6ralcn8p	293	37	ESCRT)-II	ESCRT)-II	NNP
cord-012418-6ralcn8p	293	38	[	[	-LRB-
cord-012418-6ralcn8p	293	39	139	139	CD
cord-012418-6ralcn8p	293	40	]	]	-RRB-
cord-012418-6ralcn8p	293	41	.	.	.
cord-012418-6ralcn8p	294	1	After	after	IN
cord-012418-6ralcn8p	294	2	virus	virus	NN
cord-012418-6ralcn8p	294	3	infection	infection	NN
cord-012418-6ralcn8p	294	4	,	,	,
cord-012418-6ralcn8p	294	5	a	a	DT
cord-012418-6ralcn8p	294	6	fraction	fraction	NN
cord-012418-6ralcn8p	294	7	of	of	IN
cord-012418-6ralcn8p	294	8	the	the	DT
cord-012418-6ralcn8p	294	9	ESCRT	ESCRT	NNP
cord-012418-6ralcn8p	294	10	-	-	HYPH
cord-012418-6ralcn8p	294	11	II	II	NNP
cord-012418-6ralcn8p	294	12	subunit	subunit	NN
cord-012418-6ralcn8p	294	13	ELL	ELL	NNP
cord-012418-6ralcn8p	294	14	-	-	HYPH
cord-012418-6ralcn8p	294	15	associated	associate	VBN
cord-012418-6ralcn8p	294	16	protein	protein	NN
cord-012418-6ralcn8p	294	17	of	of	IN
cord-012418-6ralcn8p	294	18	30	30	CD
cord-012418-6ralcn8p	294	19	kDa	kDa	NNS
cord-012418-6ralcn8p	294	20	(	(	-LRB-
cord-012418-6ralcn8p	294	21	EAP30	EAP30	NNP
cord-012418-6ralcn8p	294	22	,	,	,
cord-012418-6ralcn8p	294	23	also	also	RB
cord-012418-6ralcn8p	294	24	known	know	VBN
cord-012418-6ralcn8p	294	25	as	as	IN
cord-012418-6ralcn8p	294	26	SFN8	SFN8	NNP
cord-012418-6ralcn8p	294	27	)	)	-RRB-
cord-012418-6ralcn8p	294	28	localises	localise	NNS
cord-012418-6ralcn8p	294	29	to	to	IN
cord-012418-6ralcn8p	294	30	the	the	DT
cord-012418-6ralcn8p	294	31	nucleus	nucleus	NN
cord-012418-6ralcn8p	294	32	where	where	WRB
cord-012418-6ralcn8p	294	33	it	-PRON-	PRP
cord-012418-6ralcn8p	294	34	interacts	interact	VBZ
cord-012418-6ralcn8p	294	35	with	with	IN
cord-012418-6ralcn8p	294	36	activated	activate	VBN
cord-012418-6ralcn8p	294	37	IRF3	IRF3	NNP
cord-012418-6ralcn8p	294	38	and	and	CC
cord-012418-6ralcn8p	294	39	CBP	CBP	NNP
cord-012418-6ralcn8p	294	40	and	and	CC
cord-012418-6ralcn8p	294	41	promotes	promote	VBZ
cord-012418-6ralcn8p	294	42	binding	binding	NN
cord-012418-6ralcn8p	294	43	of	of	IN
cord-012418-6ralcn8p	294	44	the	the	DT
cord-012418-6ralcn8p	294	45	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	294	46	to	to	TO
cord-012418-6ralcn8p	294	47	target	target	VB
cord-012418-6ralcn8p	294	48	gene	gene	NN
cord-012418-6ralcn8p	294	49	promoters	promoter	NNS
cord-012418-6ralcn8p	294	50	.	.	.
cord-012418-6ralcn8p	295	1	Contrasting	contrast	VBG
cord-012418-6ralcn8p	295	2	this	this	DT
cord-012418-6ralcn8p	295	3	,	,	,
cord-012418-6ralcn8p	295	4	the	the	DT
cord-012418-6ralcn8p	295	5	protein	protein	NN
cord-012418-6ralcn8p	295	6	Argonaut	Argonaut	NNP
cord-012418-6ralcn8p	295	7	2	2	CD
cord-012418-6ralcn8p	295	8	(	(	-LRB-
cord-012418-6ralcn8p	295	9	AGO2	AGO2	NNP
cord-012418-6ralcn8p	295	10	)	)	-RRB-
cord-012418-6ralcn8p	295	11	,	,	,
cord-012418-6ralcn8p	295	12	a	a	DT
cord-012418-6ralcn8p	295	13	component	component	NN
cord-012418-6ralcn8p	295	14	of	of	IN
cord-012418-6ralcn8p	295	15	the	the	DT
cord-012418-6ralcn8p	295	16	RNA	RNA	NNP
cord-012418-6ralcn8p	295	17	-	-	HYPH
cord-012418-6ralcn8p	295	18	induced	induce	VBN
cord-012418-6ralcn8p	295	19	silencing	silence	VBG
cord-012418-6ralcn8p	295	20	complex	complex	NN
cord-012418-6ralcn8p	295	21	,	,	,
cord-012418-6ralcn8p	295	22	interacts	interact	VBZ
cord-012418-6ralcn8p	295	23	with	with	IN
cord-012418-6ralcn8p	295	24	the	the	DT
cord-012418-6ralcn8p	295	25	IAD	IAD	NNP
cord-012418-6ralcn8p	295	26	of	of	IN
cord-012418-6ralcn8p	295	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	295	28	and	and	CC
cord-012418-6ralcn8p	295	29	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	295	30	its	-PRON-	PRP$
cord-012418-6ralcn8p	295	31	association	association	NN
cord-012418-6ralcn8p	295	32	with	with	IN
cord-012418-6ralcn8p	295	33	CBP	CBP	NNP
cord-012418-6ralcn8p	295	34	in	in	IN
cord-012418-6ralcn8p	295	35	the	the	DT
cord-012418-6ralcn8p	295	36	nucleus	nucleus	NN
cord-012418-6ralcn8p	295	37	in	in	IN
cord-012418-6ralcn8p	295	38	latent	latent	JJ
cord-012418-6ralcn8p	295	39	conditions	condition	NNS
cord-012418-6ralcn8p	295	40	[	[	-LRB-
cord-012418-6ralcn8p	295	41	140	140	CD
cord-012418-6ralcn8p	295	42	]	]	-RRB-
cord-012418-6ralcn8p	295	43	.	.	.
cord-012418-6ralcn8p	296	1	Upon	upon	IN
cord-012418-6ralcn8p	296	2	viral	viral	JJ
cord-012418-6ralcn8p	296	3	infection	infection	NN
cord-012418-6ralcn8p	296	4	,	,	,
cord-012418-6ralcn8p	296	5	however	however	RB
cord-012418-6ralcn8p	296	6	,	,	,
cord-012418-6ralcn8p	296	7	AGO2	AGO2	NNP
cord-012418-6ralcn8p	296	8	is	be	VBZ
cord-012418-6ralcn8p	296	9	exported	export	VBN
cord-012418-6ralcn8p	296	10	from	from	IN
cord-012418-6ralcn8p	296	11	the	the	DT
cord-012418-6ralcn8p	296	12	nucleus	nucleus	NN
cord-012418-6ralcn8p	296	13	,	,	,
cord-012418-6ralcn8p	296	14	and	and	CC
cord-012418-6ralcn8p	296	15	its	-PRON-	PRP$
cord-012418-6ralcn8p	296	16	inhibition	inhibition	NN
cord-012418-6ralcn8p	296	17	is	be	VBZ
cord-012418-6ralcn8p	296	18	revoked	revoke	VBN
cord-012418-6ralcn8p	296	19	to	to	TO
cord-012418-6ralcn8p	296	20	promote	promote	VB
cord-012418-6ralcn8p	296	21	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	296	22	production	production	NN
cord-012418-6ralcn8p	296	23	during	during	IN
cord-012418-6ralcn8p	296	24	infection	infection	NN
cord-012418-6ralcn8p	296	25	[	[	-LRB-
cord-012418-6ralcn8p	296	26	140	140	CD
cord-012418-6ralcn8p	296	27	]	]	-RRB-
cord-012418-6ralcn8p	296	28	.	.	.
cord-012418-6ralcn8p	297	1	A	a	DT
cord-012418-6ralcn8p	297	2	further	further	JJ
cord-012418-6ralcn8p	297	3	mechanism	mechanism	NN
cord-012418-6ralcn8p	297	4	of	of	IN
cord-012418-6ralcn8p	297	5	signalling	signal	VBG
cord-012418-6ralcn8p	297	6	amplification	amplification	NN
cord-012418-6ralcn8p	297	7	is	be	VBZ
cord-012418-6ralcn8p	297	8	set	set	VBN
cord-012418-6ralcn8p	297	9	into	into	IN
cord-012418-6ralcn8p	297	10	motion	motion	NN
cord-012418-6ralcn8p	297	11	by	by	IN
cord-012418-6ralcn8p	297	12	type	type	NN
cord-012418-6ralcn8p	298	1	I	-PRON-	PRP
cord-012418-6ralcn8p	298	2	IFN	IFN	NNP
cord-012418-6ralcn8p	298	3	-	-	HYPH
cord-012418-6ralcn8p	298	4	stimulated	stimulate	VBN
cord-012418-6ralcn8p	298	5	production	production	NN
cord-012418-6ralcn8p	298	6	of	of	IN
cord-012418-6ralcn8p	298	7	the	the	DT
cord-012418-6ralcn8p	298	8	E74	E74	NNP
cord-012418-6ralcn8p	298	9	like	like	IN
cord-012418-6ralcn8p	298	10	ETS	ETS	NNP
cord-012418-6ralcn8p	298	11	transcription	transcription	NN
cord-012418-6ralcn8p	298	12	factor	factor	NN
cord-012418-6ralcn8p	298	13	4	4	CD
cord-012418-6ralcn8p	298	14	(	(	-LRB-
cord-012418-6ralcn8p	298	15	ELF4	ELF4	NNP
cord-012418-6ralcn8p	298	16	)	)	-RRB-
cord-012418-6ralcn8p	298	17	.	.	.
cord-012418-6ralcn8p	299	1	ELF4	ELF4	NNP
cord-012418-6ralcn8p	299	2	is	be	VBZ
cord-012418-6ralcn8p	299	3	recruited	recruit	VBN
cord-012418-6ralcn8p	299	4	to	to	TO
cord-012418-6ralcn8p	299	5	STING	sting	VB
cord-012418-6ralcn8p	299	6	and	and	CC
cord-012418-6ralcn8p	299	7	activated	activate	VBN
cord-012418-6ralcn8p	299	8	by	by	IN
cord-012418-6ralcn8p	299	9	TBK1	TBK1	NNP
cord-012418-6ralcn8p	299	10	similar	similar	JJ
cord-012418-6ralcn8p	299	11	to	to	IN
cord-012418-6ralcn8p	299	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	299	13	after	after	IN
cord-012418-6ralcn8p	299	14	viral	viral	JJ
cord-012418-6ralcn8p	299	15	stimulation	stimulation	NN
cord-012418-6ralcn8p	299	16	,	,	,
cord-012418-6ralcn8p	299	17	though	though	IN
cord-012418-6ralcn8p	299	18	without	without	IN
cord-012418-6ralcn8p	299	19	affecting	affect	VBG
cord-012418-6ralcn8p	299	20	IRF3	IRF3	NNP
cord-012418-6ralcn8p	299	21	activation	activation	NN
cord-012418-6ralcn8p	299	22	itself	-PRON-	PRP
cord-012418-6ralcn8p	299	23	[	[	-LRB-
cord-012418-6ralcn8p	299	24	141	141	CD
cord-012418-6ralcn8p	299	25	]	]	-RRB-
cord-012418-6ralcn8p	299	26	.	.	.
cord-012418-6ralcn8p	300	1	Activated	Activated	NNP
cord-012418-6ralcn8p	300	2	ELF4	ELF4	NNP
cord-012418-6ralcn8p	300	3	enters	enter	VBZ
cord-012418-6ralcn8p	300	4	the	the	DT
cord-012418-6ralcn8p	300	5	nucleus	nucleus	NN
cord-012418-6ralcn8p	300	6	and	and	CC
cord-012418-6ralcn8p	300	7	binds	bind	VBZ
cord-012418-6ralcn8p	300	8	to	to	IN
cord-012418-6ralcn8p	300	9	the	the	DT
cord-012418-6ralcn8p	300	10	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	300	11	promoter	promoter	NN
cord-012418-6ralcn8p	300	12	region	region	NN
cord-012418-6ralcn8p	300	13	via	via	IN
cord-012418-6ralcn8p	300	14	ETS	ETS	NNP
cord-012418-6ralcn8p	300	15	/	/	SYM
cord-012418-6ralcn8p	300	16	IRF	IRF	NNP
cord-012418-6ralcn8p	300	17	composite	composite	JJ
cord-012418-6ralcn8p	300	18	binding	binding	NN
cord-012418-6ralcn8p	300	19	elements	element	NNS
cord-012418-6ralcn8p	300	20	(	(	-LRB-
cord-012418-6ralcn8p	300	21	EICEs	EICEs	NNP
cord-012418-6ralcn8p	300	22	)	)	-RRB-
cord-012418-6ralcn8p	300	23	.	.	.
cord-012418-6ralcn8p	301	1	DNA	dna	NN
cord-012418-6ralcn8p	301	2	binding	binding	NN
cord-012418-6ralcn8p	301	3	of	of	IN
cord-012418-6ralcn8p	301	4	ELF4	ELF4	NNP
cord-012418-6ralcn8p	301	5	synergises	synergise	NNS
cord-012418-6ralcn8p	301	6	with	with	IN
cord-012418-6ralcn8p	301	7	binding	binding	NN
cord-012418-6ralcn8p	301	8	of	of	IN
cord-012418-6ralcn8p	301	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	301	10	,	,	,
cord-012418-6ralcn8p	301	11	and	and	CC
cord-012418-6ralcn8p	301	12	thus	thus	RB
cord-012418-6ralcn8p	301	13	promotes	promote	VBZ
cord-012418-6ralcn8p	301	14	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	301	15	formation	formation	NN
cord-012418-6ralcn8p	301	16	.	.	.
cord-012418-6ralcn8p	302	1	The	the	DT
cord-012418-6ralcn8p	302	2	critical	critical	JJ
cord-012418-6ralcn8p	302	3	role	role	NN
cord-012418-6ralcn8p	302	4	of	of	IN
cord-012418-6ralcn8p	302	5	ELF4	ELF4	NNP
cord-012418-6ralcn8p	302	6	in	in	IN
cord-012418-6ralcn8p	302	7	the	the	DT
cord-012418-6ralcn8p	302	8	feed	feed	VB
cord-012418-6ralcn8p	302	9	-	-	HYPH
cord-012418-6ralcn8p	302	10	forward	forward	RP
cord-012418-6ralcn8p	302	11	amplification	amplification	NN
cord-012418-6ralcn8p	302	12	of	of	IN
cord-012418-6ralcn8p	302	13	the	the	DT
cord-012418-6ralcn8p	302	14	murine	murine	JJ
cord-012418-6ralcn8p	302	15	antiviral	antiviral	JJ
cord-012418-6ralcn8p	302	16	immune	immune	JJ
cord-012418-6ralcn8p	302	17	response	response	NN
cord-012418-6ralcn8p	302	18	was	be	VBD
cord-012418-6ralcn8p	302	19	demonstrated	demonstrate	VBN
cord-012418-6ralcn8p	302	20	in	in	IN
cord-012418-6ralcn8p	302	21	vivo	vivo	NN
cord-012418-6ralcn8p	302	22	,	,	,
cord-012418-6ralcn8p	302	23	and	and	CC
cord-012418-6ralcn8p	302	24	notably	notably	RB
cord-012418-6ralcn8p	302	25	,	,	,
cord-012418-6ralcn8p	302	26	it	-PRON-	PRP
cord-012418-6ralcn8p	302	27	is	be	VBZ
cord-012418-6ralcn8p	302	28	independent	independent	JJ
cord-012418-6ralcn8p	302	29	of	of	IN
cord-012418-6ralcn8p	302	30	the	the	DT
cord-012418-6ralcn8p	302	31	signalling	signalling	NN
cord-012418-6ralcn8p	302	32	in	in	IN
cord-012418-6ralcn8p	302	33	plasmacytoid	plasmacytoid	NNP
cord-012418-6ralcn8p	302	34	dendritic	dendritic	JJ
cord-012418-6ralcn8p	302	35	cells	cell	NNS
cord-012418-6ralcn8p	302	36	[	[	-LRB-
cord-012418-6ralcn8p	302	37	141	141	CD
cord-012418-6ralcn8p	302	38	]	]	-RRB-
cord-012418-6ralcn8p	302	39	.	.	.
cord-012418-6ralcn8p	303	1	In	in	IN
cord-012418-6ralcn8p	303	2	contrast	contrast	NN
cord-012418-6ralcn8p	303	3	,	,	,
cord-012418-6ralcn8p	303	4	a	a	DT
cord-012418-6ralcn8p	303	5	mechanism	mechanism	NN
cord-012418-6ralcn8p	303	6	that	that	WDT
cord-012418-6ralcn8p	303	7	due	due	IN
cord-012418-6ralcn8p	303	8	to	to	IN
cord-012418-6ralcn8p	303	9	the	the	DT
cord-012418-6ralcn8p	303	10	predominating	predominating	JJ
cord-012418-6ralcn8p	303	11	expression	expression	NN
cord-012418-6ralcn8p	303	12	of	of	IN
cord-012418-6ralcn8p	303	13	both	both	DT
cord-012418-6ralcn8p	303	14	factors	factor	NNS
cord-012418-6ralcn8p	303	15	in	in	IN
cord-012418-6ralcn8p	303	16	tissues	tissue	NNS
cord-012418-6ralcn8p	303	17	of	of	IN
cord-012418-6ralcn8p	303	18	the	the	DT
cord-012418-6ralcn8p	303	19	immune	immune	JJ
cord-012418-6ralcn8p	303	20	system	system	NN
cord-012418-6ralcn8p	303	21	applies	apply	VBZ
cord-012418-6ralcn8p	303	22	exclusively	exclusively	RB
cord-012418-6ralcn8p	303	23	to	to	IN
cord-012418-6ralcn8p	303	24	immune	immune	JJ
cord-012418-6ralcn8p	303	25	cells	cell	NNS
cord-012418-6ralcn8p	303	26	is	be	VBZ
cord-012418-6ralcn8p	303	27	the	the	DT
cord-012418-6ralcn8p	303	28	association	association	NN
cord-012418-6ralcn8p	303	29	of	of	IN
cord-012418-6ralcn8p	303	30	IRF8	IRF8	NNP
cord-012418-6ralcn8p	303	31	together	together	RB
cord-012418-6ralcn8p	303	32	with	with	IN
cord-012418-6ralcn8p	303	33	the	the	DT
cord-012418-6ralcn8p	303	34	transcription	transcription	NN
cord-012418-6ralcn8p	303	35	factor	factor	NN
cord-012418-6ralcn8p	303	36	PU.1	PU.1	NNP
cord-012418-6ralcn8p	304	1	(	(	-LRB-
cord-012418-6ralcn8p	304	2	also	also	RB
cord-012418-6ralcn8p	304	3	SPI1	SPI1	NNP
cord-012418-6ralcn8p	304	4	,	,	,
cord-012418-6ralcn8p	304	5	Spi-1	Spi-1	NNP
cord-012418-6ralcn8p	304	6	proto	proto	JJ
cord-012418-6ralcn8p	304	7	-	-	HYPH
cord-012418-6ralcn8p	304	8	oncogene	oncogene	NN
cord-012418-6ralcn8p	304	9	)	)	-RRB-
cord-012418-6ralcn8p	304	10	to	to	IN
cord-012418-6ralcn8p	304	11	the	the	DT
cord-012418-6ralcn8p	304	12	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	304	13	promoter	promoter	NN
cord-012418-6ralcn8p	304	14	region	region	NN
cord-012418-6ralcn8p	304	15	mediated	mediate	VBN
cord-012418-6ralcn8p	304	16	by	by	IN
cord-012418-6ralcn8p	304	17	EICE	EICE	NNP
cord-012418-6ralcn8p	304	18	[	[	-LRB-
cord-012418-6ralcn8p	304	19	142	142	CD
cord-012418-6ralcn8p	304	20	]	]	-RRB-
cord-012418-6ralcn8p	304	21	.	.	.
cord-012418-6ralcn8p	305	1	Li	Li	NNP
cord-012418-6ralcn8p	305	2	and	and	CC
cord-012418-6ralcn8p	305	3	colleagues	colleague	NNS
cord-012418-6ralcn8p	305	4	proposed	propose	VBD
cord-012418-6ralcn8p	305	5	that	that	IN
cord-012418-6ralcn8p	305	6	IRF8	IRF8	NNP
cord-012418-6ralcn8p	305	7	and	and	CC
cord-012418-6ralcn8p	305	8	PU.1	PU.1	NNP
cord-012418-6ralcn8p	305	9	support	support	VBP
cord-012418-6ralcn8p	305	10	the	the	DT
cord-012418-6ralcn8p	305	11	rapid	rapid	JJ
cord-012418-6ralcn8p	305	12	induction	induction	NN
cord-012418-6ralcn8p	305	13	of	of	IN
cord-012418-6ralcn8p	305	14	transcription	transcription	NN
cord-012418-6ralcn8p	305	15	by	by	IN
cord-012418-6ralcn8p	305	16	forming	form	VBG
cord-012418-6ralcn8p	305	17	a	a	DT
cord-012418-6ralcn8p	305	18	scaffold	scaffold	NN
cord-012418-6ralcn8p	305	19	at	at	IN
cord-012418-6ralcn8p	305	20	the	the	DT
cord-012418-6ralcn8p	305	21	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	305	22	enhancer	enhancer	NN
cord-012418-6ralcn8p	305	23	to	to	TO
cord-012418-6ralcn8p	305	24	facilitate	facilitate	VB
cord-012418-6ralcn8p	305	25	recruitment	recruitment	NN
cord-012418-6ralcn8p	305	26	of	of	IN
cord-012418-6ralcn8p	305	27	activated	activate	VBN
cord-012418-6ralcn8p	305	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	305	29	[	[	-LRB-
cord-012418-6ralcn8p	305	30	142	142	CD
cord-012418-6ralcn8p	305	31	]	]	-RRB-
cord-012418-6ralcn8p	305	32	.	.	.
cord-012418-6ralcn8p	306	1	A	a	DT
cord-012418-6ralcn8p	306	2	striking	striking	JJ
cord-012418-6ralcn8p	306	3	feature	feature	NN
cord-012418-6ralcn8p	306	4	of	of	IN
cord-012418-6ralcn8p	306	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	306	6	modulation	modulation	NN
cord-012418-6ralcn8p	306	7	is	be	VBZ
cord-012418-6ralcn8p	306	8	reflected	reflect	VBN
cord-012418-6ralcn8p	306	9	by	by	IN
cord-012418-6ralcn8p	306	10	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	306	11	that	that	WDT
cord-012418-6ralcn8p	306	12	are	be	VBP
cord-012418-6ralcn8p	306	13	installed	instal	VBN
cord-012418-6ralcn8p	306	14	not	not	RB
cord-012418-6ralcn8p	306	15	to	to	TO
cord-012418-6ralcn8p	306	16	plainly	plainly	RB
cord-012418-6ralcn8p	306	17	heighten	heighten	VB
cord-012418-6ralcn8p	306	18	or	or	CC
cord-012418-6ralcn8p	306	19	terminate	terminate	VB
cord-012418-6ralcn8p	306	20	the	the	DT
cord-012418-6ralcn8p	306	21	biological	biological	JJ
cord-012418-6ralcn8p	306	22	activity	activity	NN
cord-012418-6ralcn8p	306	23	of	of	IN
cord-012418-6ralcn8p	306	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	306	25	but	but	CC
cord-012418-6ralcn8p	306	26	to	to	TO
cord-012418-6ralcn8p	306	27	moderate	moderate	VB
cord-012418-6ralcn8p	306	28	its	-PRON-	PRP$
cord-012418-6ralcn8p	306	29	extent	extent	NN
cord-012418-6ralcn8p	306	30	.	.	.
cord-012418-6ralcn8p	307	1	Some	some	DT
cord-012418-6ralcn8p	307	2	of	of	IN
cord-012418-6ralcn8p	307	3	the	the	DT
cord-012418-6ralcn8p	307	4	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	307	5	delineated	delineate	VBN
cord-012418-6ralcn8p	307	6	here	here	RB
cord-012418-6ralcn8p	307	7	affect	affect	VBP
cord-012418-6ralcn8p	307	8	the	the	DT
cord-012418-6ralcn8p	307	9	latent	latent	JJ
cord-012418-6ralcn8p	307	10	protein	protein	NN
cord-012418-6ralcn8p	307	11	,	,	,
cord-012418-6ralcn8p	307	12	others	other	NNS
cord-012418-6ralcn8p	307	13	specifically	specifically	RB
cord-012418-6ralcn8p	307	14	target	target	VB
cord-012418-6ralcn8p	307	15	activated	activate	VBN
cord-012418-6ralcn8p	307	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	307	17	after	after	IN
cord-012418-6ralcn8p	307	18	viral	viral	JJ
cord-012418-6ralcn8p	307	19	stimulation	stimulation	NN
cord-012418-6ralcn8p	307	20	and	and	CC
cord-012418-6ralcn8p	307	21	still	still	RB
cord-012418-6ralcn8p	307	22	others	other	NNS
cord-012418-6ralcn8p	307	23	act	act	VBP
cord-012418-6ralcn8p	307	24	on	on	IN
cord-012418-6ralcn8p	307	25	both	both	DT
cord-012418-6ralcn8p	307	26	.	.	.
cord-012418-6ralcn8p	308	1	Macrophages	macrophage	NNS
cord-012418-6ralcn8p	308	2	are	be	VBP
cord-012418-6ralcn8p	308	3	a	a	DT
cord-012418-6ralcn8p	308	4	prime	prime	JJ
cord-012418-6ralcn8p	308	5	example	example	NN
cord-012418-6ralcn8p	308	6	in	in	IN
cord-012418-6ralcn8p	308	7	deploying	deploy	VBG
cord-012418-6ralcn8p	308	8	numerous	numerous	JJ
cord-012418-6ralcn8p	308	9	modulators	modulator	NNS
cord-012418-6ralcn8p	308	10	to	to	TO
cord-012418-6ralcn8p	308	11	dampen	dampen	VB
cord-012418-6ralcn8p	308	12	fluctuations	fluctuation	NNS
cord-012418-6ralcn8p	308	13	of	of	IN
cord-012418-6ralcn8p	308	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	308	15	activity	activity	NN
cord-012418-6ralcn8p	308	16	until	until	IN
cord-012418-6ralcn8p	308	17	a	a	DT
cord-012418-6ralcn8p	308	18	certain	certain	JJ
cord-012418-6ralcn8p	308	19	threshold	threshold	NN
cord-012418-6ralcn8p	308	20	is	be	VBZ
cord-012418-6ralcn8p	308	21	passed	pass	VBN
cord-012418-6ralcn8p	308	22	and	and	CC
cord-012418-6ralcn8p	308	23	further	far	RBR
cord-012418-6ralcn8p	308	24	to	to	TO
cord-012418-6ralcn8p	308	25	restrain	restrain	VB
cord-012418-6ralcn8p	308	26	the	the	DT
cord-012418-6ralcn8p	308	27	response	response	NN
cord-012418-6ralcn8p	308	28	once	once	RB
cord-012418-6ralcn8p	308	29	unleashed	unleash	VBD
cord-012418-6ralcn8p	308	30	.	.	.
cord-012418-6ralcn8p	309	1	For	for	IN
cord-012418-6ralcn8p	309	2	example	example	NN
cord-012418-6ralcn8p	309	3	,	,	,
cord-012418-6ralcn8p	309	4	the	the	DT
cord-012418-6ralcn8p	309	5	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	309	6	-	-	HYPH
cord-012418-6ralcn8p	309	7	protein	protein	NN
cord-012418-6ralcn8p	309	8	ligase	ligase	NN
cord-012418-6ralcn8p	309	9	E3C	e3c	NN
cord-012418-6ralcn8p	309	10	(	(	-LRB-
cord-012418-6ralcn8p	309	11	UBE3C	ube3c	NN
cord-012418-6ralcn8p	309	12	)	)	-RRB-
cord-012418-6ralcn8p	309	13	mediates	mediate	VBZ
cord-012418-6ralcn8p	309	14	K48-linked	k48-linke	VBN
cord-012418-6ralcn8p	309	15	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	309	16	of	of	IN
cord-012418-6ralcn8p	309	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	309	18	and	and	CC
cord-012418-6ralcn8p	309	19	IRF7	IRF7	NNP
cord-012418-6ralcn8p	309	20	,	,	,
cord-012418-6ralcn8p	309	21	thereby	thereby	RB
cord-012418-6ralcn8p	309	22	targeting	target	VBG
cord-012418-6ralcn8p	309	23	the	the	DT
cord-012418-6ralcn8p	309	24	master	master	NN
cord-012418-6ralcn8p	309	25	transcription	transcription	NN
cord-012418-6ralcn8p	309	26	regulators	regulator	NNS
cord-012418-6ralcn8p	309	27	in	in	IN
cord-012418-6ralcn8p	309	28	dendritic	dendritic	JJ
cord-012418-6ralcn8p	309	29	cells	cell	NNS
cord-012418-6ralcn8p	309	30	for	for	IN
cord-012418-6ralcn8p	309	31	proteolysis	proteolysis	NN
cord-012418-6ralcn8p	309	32	,	,	,
cord-012418-6ralcn8p	309	33	irrespective	irrespective	RB
cord-012418-6ralcn8p	309	34	of	of	IN
cord-012418-6ralcn8p	309	35	their	-PRON-	PRP$
cord-012418-6ralcn8p	309	36	activation	activation	NN
cord-012418-6ralcn8p	309	37	state	state	NN
cord-012418-6ralcn8p	309	38	[	[	-LRB-
cord-012418-6ralcn8p	309	39	143	143	CD
cord-012418-6ralcn8p	309	40	]	]	-RRB-
cord-012418-6ralcn8p	309	41	.	.	.
cord-012418-6ralcn8p	310	1	In	in	IN
cord-012418-6ralcn8p	310	2	this	this	DT
cord-012418-6ralcn8p	310	3	way	way	NN
cord-012418-6ralcn8p	310	4	,	,	,
cord-012418-6ralcn8p	310	5	UBE3C	UBE3C	NNP
cord-012418-6ralcn8p	310	6	helps	help	VBZ
cord-012418-6ralcn8p	310	7	to	to	TO
cord-012418-6ralcn8p	310	8	maintain	maintain	VB
cord-012418-6ralcn8p	310	9	low	low	JJ
cord-012418-6ralcn8p	310	10	amounts	amount	NNS
cord-012418-6ralcn8p	310	11	of	of	IN
cord-012418-6ralcn8p	310	12	IFN	IFN	NNP
cord-012418-6ralcn8p	310	13	production	production	NN
cord-012418-6ralcn8p	310	14	in	in	IN
cord-012418-6ralcn8p	310	15	resting	rest	VBG
cord-012418-6ralcn8p	310	16	conditions	condition	NNS
cord-012418-6ralcn8p	310	17	and	and	CC
cord-012418-6ralcn8p	310	18	additionally	additionally	RB
cord-012418-6ralcn8p	310	19	restrains	restrain	VBZ
cord-012418-6ralcn8p	310	20	the	the	DT
cord-012418-6ralcn8p	310	21	magnitude	magnitude	NN
cord-012418-6ralcn8p	310	22	of	of	IN
cord-012418-6ralcn8p	310	23	the	the	DT
cord-012418-6ralcn8p	310	24	response	response	NN
cord-012418-6ralcn8p	310	25	after	after	IN
cord-012418-6ralcn8p	310	26	stimulation	stimulation	NN
cord-012418-6ralcn8p	310	27	[	[	-LRB-
cord-012418-6ralcn8p	310	28	125	125	CD
cord-012418-6ralcn8p	310	29	,	,	,
cord-012418-6ralcn8p	310	30	143	143	CD
cord-012418-6ralcn8p	310	31	]	]	-RRB-
cord-012418-6ralcn8p	310	32	.	.	.
cord-012418-6ralcn8p	311	1	Another	another	DT
cord-012418-6ralcn8p	311	2	E3	e3	NN
cord-012418-6ralcn8p	311	3	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	311	4	ligase	ligase	NN
cord-012418-6ralcn8p	311	5	,	,	,
cord-012418-6ralcn8p	311	6	tripartite	tripartite	JJ
cord-012418-6ralcn8p	311	7	motif	motif	NN
cord-012418-6ralcn8p	311	8	-	-	:
cord-012418-6ralcn8p	311	9	containing	contain	VBG
cord-012418-6ralcn8p	311	10	21	21	CD
cord-012418-6ralcn8p	312	1	(	(	-LRB-
cord-012418-6ralcn8p	312	2	TRIM21	trim21	VB
cord-012418-6ralcn8p	312	3	or	or	CC
cord-012418-6ralcn8p	312	4	Ro52	ro52	ADD
cord-012418-6ralcn8p	312	5	)	)	-RRB-
cord-012418-6ralcn8p	312	6	,	,	,
cord-012418-6ralcn8p	312	7	was	be	VBD
cord-012418-6ralcn8p	312	8	described	describe	VBN
cord-012418-6ralcn8p	312	9	by	by	IN
cord-012418-6ralcn8p	312	10	two	two	CD
cord-012418-6ralcn8p	312	11	groups	group	NNS
cord-012418-6ralcn8p	312	12	to	to	TO
cord-012418-6ralcn8p	312	13	be	be	VB
cord-012418-6ralcn8p	312	14	important	important	JJ
cord-012418-6ralcn8p	312	15	for	for	IN
cord-012418-6ralcn8p	312	16	regulation	regulation	NN
cord-012418-6ralcn8p	312	17	of	of	IN
cord-012418-6ralcn8p	312	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	312	19	but	but	CC
cord-012418-6ralcn8p	312	20	with	with	IN
cord-012418-6ralcn8p	312	21	opposing	oppose	VBG
cord-012418-6ralcn8p	312	22	findings	finding	NNS
cord-012418-6ralcn8p	312	23	as	as	IN
cord-012418-6ralcn8p	312	24	already	already	RB
cord-012418-6ralcn8p	312	25	discussed	discuss	VBN
cord-012418-6ralcn8p	312	26	by	by	IN
cord-012418-6ralcn8p	312	27	Sin	sin	NN
cord-012418-6ralcn8p	312	28	[	[	-LRB-
cord-012418-6ralcn8p	312	29	125	125	CD
cord-012418-6ralcn8p	312	30	]	]	-RRB-
cord-012418-6ralcn8p	313	1	:	:	:
cord-012418-6ralcn8p	313	2	Higgs	Higgs	NNP
cord-012418-6ralcn8p	313	3	and	and	CC
cord-012418-6ralcn8p	313	4	colleagues	colleague	NNS
cord-012418-6ralcn8p	313	5	reported	report	VBD
cord-012418-6ralcn8p	313	6	TRIM21-dependent	trim21-dependent	NN
cord-012418-6ralcn8p	313	7	mediation	mediation	NN
cord-012418-6ralcn8p	313	8	of	of	IN
cord-012418-6ralcn8p	313	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	313	10	degradation	degradation	NN
cord-012418-6ralcn8p	313	11	48	48	CD
cord-012418-6ralcn8p	313	12	hours	hour	NNS
cord-012418-6ralcn8p	313	13	after	after	IN
cord-012418-6ralcn8p	313	14	infection	infection	NN
cord-012418-6ralcn8p	313	15	[	[	-LRB-
cord-012418-6ralcn8p	313	16	144	144	CD
cord-012418-6ralcn8p	313	17	]	]	-RRB-
cord-012418-6ralcn8p	313	18	,	,	,
cord-012418-6ralcn8p	313	19	whereas	whereas	IN
cord-012418-6ralcn8p	313	20	Yang	Yang	NNP
cord-012418-6ralcn8p	313	21	and	and	CC
cord-012418-6ralcn8p	313	22	colleagues	colleague	NNS
cord-012418-6ralcn8p	313	23	found	find	VBD
cord-012418-6ralcn8p	313	24	that	that	IN
cord-012418-6ralcn8p	313	25	nine	nine	CD
cord-012418-6ralcn8p	313	26	hours	hour	NNS
cord-012418-6ralcn8p	313	27	after	after	IN
cord-012418-6ralcn8p	313	28	infection	infection	NN
cord-012418-6ralcn8p	313	29	,	,	,
cord-012418-6ralcn8p	313	30	TRIM21	trim21	NN
cord-012418-6ralcn8p	313	31	interferes	interfere	VBZ
cord-012418-6ralcn8p	313	32	with	with	IN
cord-012418-6ralcn8p	313	33	the	the	DT
cord-012418-6ralcn8p	313	34	interaction	interaction	NN
cord-012418-6ralcn8p	313	35	between	between	IN
cord-012418-6ralcn8p	313	36	IRF3	IRF3	NNP
cord-012418-6ralcn8p	313	37	and	and	CC
cord-012418-6ralcn8p	313	38	Pin1	Pin1	NNP
cord-012418-6ralcn8p	313	39	and	and	CC
cord-012418-6ralcn8p	313	40	in	in	IN
cord-012418-6ralcn8p	313	41	this	this	DT
cord-012418-6ralcn8p	313	42	way	way	NN
cord-012418-6ralcn8p	313	43	prevents	prevent	VBZ
cord-012418-6ralcn8p	313	44	Pin1-mediated	pin1-mediate	VBN
cord-012418-6ralcn8p	313	45	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	313	46	and	and	CC
cord-012418-6ralcn8p	313	47	degradation	degradation	NN
cord-012418-6ralcn8p	313	48	of	of	IN
cord-012418-6ralcn8p	313	49	IRF3	IRF3	NNP
cord-012418-6ralcn8p	313	50	to	to	TO
cord-012418-6ralcn8p	313	51	sustain	sustain	VB
cord-012418-6ralcn8p	313	52	the	the	DT
cord-012418-6ralcn8p	313	53	immune	immune	JJ
cord-012418-6ralcn8p	313	54	response	response	NN
cord-012418-6ralcn8p	313	55	[	[	-LRB-
cord-012418-6ralcn8p	313	56	145	145	CD
cord-012418-6ralcn8p	313	57	]	]	-RRB-
cord-012418-6ralcn8p	313	58	.	.	.
cord-012418-6ralcn8p	314	1	Sin	sin	NN
cord-012418-6ralcn8p	314	2	suggested	suggest	VBD
cord-012418-6ralcn8p	314	3	that	that	IN
cord-012418-6ralcn8p	314	4	,	,	,
cord-012418-6ralcn8p	314	5	in	in	IN
cord-012418-6ralcn8p	314	6	addition	addition	NN
cord-012418-6ralcn8p	314	7	to	to	IN
cord-012418-6ralcn8p	314	8	effects	effect	NNS
cord-012418-6ralcn8p	314	9	potentially	potentially	RB
cord-012418-6ralcn8p	314	10	imposed	impose	VBN
cord-012418-6ralcn8p	314	11	by	by	IN
cord-012418-6ralcn8p	314	12	different	different	JJ
cord-012418-6ralcn8p	314	13	cell	cell	NN
cord-012418-6ralcn8p	314	14	lines	line	NNS
cord-012418-6ralcn8p	314	15	,	,	,
cord-012418-6ralcn8p	314	16	the	the	DT
cord-012418-6ralcn8p	314	17	observation	observation	NN
cord-012418-6ralcn8p	314	18	at	at	IN
cord-012418-6ralcn8p	314	19	different	different	JJ
cord-012418-6ralcn8p	314	20	times	time	NNS
cord-012418-6ralcn8p	314	21	of	of	IN
cord-012418-6ralcn8p	314	22	ongoing	ongoing	JJ
cord-012418-6ralcn8p	314	23	infection	infection	NN
cord-012418-6ralcn8p	314	24	could	could	MD
cord-012418-6ralcn8p	314	25	have	have	VB
cord-012418-6ralcn8p	314	26	contributed	contribute	VBN
cord-012418-6ralcn8p	314	27	to	to	IN
cord-012418-6ralcn8p	314	28	the	the	DT
cord-012418-6ralcn8p	314	29	contrasting	contrast	VBG
cord-012418-6ralcn8p	314	30	findings	finding	NNS
cord-012418-6ralcn8p	314	31	[	[	-LRB-
cord-012418-6ralcn8p	314	32	125	125	CD
cord-012418-6ralcn8p	314	33	]	]	-RRB-
cord-012418-6ralcn8p	314	34	.	.	.
cord-012418-6ralcn8p	315	1	Stability	stability	NN
cord-012418-6ralcn8p	315	2	of	of	IN
cord-012418-6ralcn8p	315	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	315	4	is	be	VBZ
cord-012418-6ralcn8p	315	5	further	further	RB
cord-012418-6ralcn8p	315	6	modified	modify	VBN
cord-012418-6ralcn8p	315	7	by	by	IN
cord-012418-6ralcn8p	315	8	addition	addition	NN
cord-012418-6ralcn8p	315	9	or	or	CC
cord-012418-6ralcn8p	315	10	removal	removal	NN
cord-012418-6ralcn8p	315	11	of	of	IN
cord-012418-6ralcn8p	315	12	small	small	JJ
cord-012418-6ralcn8p	315	13	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	315	14	-	-	HYPH
cord-012418-6ralcn8p	315	15	like	like	JJ
cord-012418-6ralcn8p	315	16	modifier	modifier	NN
cord-012418-6ralcn8p	315	17	(	(	-LRB-
cord-012418-6ralcn8p	315	18	SUMO	SUMO	NNP
cord-012418-6ralcn8p	315	19	)	)	-RRB-
cord-012418-6ralcn8p	315	20	proteins	protein	NNS
cord-012418-6ralcn8p	315	21	.	.	.
cord-012418-6ralcn8p	316	1	In	in	IN
cord-012418-6ralcn8p	316	2	HEK293	HEK293	NNP
cord-012418-6ralcn8p	316	3	cells	cell	NNS
cord-012418-6ralcn8p	316	4	,	,	,
cord-012418-6ralcn8p	316	5	endogenous	endogenous	JJ
cord-012418-6ralcn8p	316	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	316	7	is	be	VBZ
cord-012418-6ralcn8p	316	8	SUMOylated	sumoylate	VBN
cord-012418-6ralcn8p	316	9	at	at	IN
cord-012418-6ralcn8p	316	10	K70	K70	NNP
cord-012418-6ralcn8p	316	11	and	and	CC
cord-012418-6ralcn8p	316	12	K87	K87	NNP
cord-012418-6ralcn8p	316	13	in	in	IN
cord-012418-6ralcn8p	316	14	its	-PRON-	PRP$
cord-012418-6ralcn8p	316	15	DBD	DBD	NNP
cord-012418-6ralcn8p	316	16	,	,	,
cord-012418-6ralcn8p	316	17	and	and	CC
cord-012418-6ralcn8p	316	18	viral	viral	JJ
cord-012418-6ralcn8p	316	19	infection	infection	NN
cord-012418-6ralcn8p	316	20	slightly	slightly	RB
cord-012418-6ralcn8p	316	21	increases	increase	VBZ
cord-012418-6ralcn8p	316	22	SUMOylation	sumoylation	NN
cord-012418-6ralcn8p	316	23	[	[	-LRB-
cord-012418-6ralcn8p	316	24	146	146	CD
cord-012418-6ralcn8p	316	25	]	]	-RRB-
cord-012418-6ralcn8p	316	26	.	.	.
cord-012418-6ralcn8p	317	1	The	the	DT
cord-012418-6ralcn8p	317	2	widely	widely	RB
cord-012418-6ralcn8p	317	3	expressed	express	VBN
cord-012418-6ralcn8p	317	4	human	human	JJ
cord-012418-6ralcn8p	317	5	sentrin	sentrin	NN
cord-012418-6ralcn8p	317	6	/	/	SYM
cord-012418-6ralcn8p	317	7	SUMO	sumo	NN
cord-012418-6ralcn8p	317	8	-	-	HYPH
cord-012418-6ralcn8p	317	9	specific	specific	JJ
cord-012418-6ralcn8p	317	10	protease	protease	NN
cord-012418-6ralcn8p	317	11	2	2	CD
cord-012418-6ralcn8p	318	1	(	(	-LRB-
cord-012418-6ralcn8p	318	2	SENP2	senp2	RB
cord-012418-6ralcn8p	318	3	)	)	-RRB-
cord-012418-6ralcn8p	318	4	removes	remove	VBZ
cord-012418-6ralcn8p	318	5	these	these	DT
cord-012418-6ralcn8p	318	6	SUMO	SUMO	NNP
cord-012418-6ralcn8p	318	7	moieties	moiety	NNS
cord-012418-6ralcn8p	318	8	and	and	CC
cord-012418-6ralcn8p	318	9	in	in	IN
cord-012418-6ralcn8p	318	10	this	this	DT
cord-012418-6ralcn8p	318	11	way	way	NN
cord-012418-6ralcn8p	318	12	conditions	condition	NNS
cord-012418-6ralcn8p	318	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	318	14	for	for	IN
cord-012418-6ralcn8p	318	15	K48-linked	K48-linked	NNP
cord-012418-6ralcn8p	318	16	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	318	17	at	at	IN
cord-012418-6ralcn8p	318	18	the	the	DT
cord-012418-6ralcn8p	318	19	same	same	JJ
cord-012418-6ralcn8p	318	20	residues	residue	NNS
cord-012418-6ralcn8p	318	21	and	and	CC
cord-012418-6ralcn8p	318	22	subsequent	subsequent	JJ
cord-012418-6ralcn8p	318	23	degradation	degradation	NN
cord-012418-6ralcn8p	318	24	,	,	,
cord-012418-6ralcn8p	318	25	thereby	thereby	RB
cord-012418-6ralcn8p	318	26	dampening	dampen	VBG
cord-012418-6ralcn8p	318	27	the	the	DT
cord-012418-6ralcn8p	318	28	antiviral	antiviral	JJ
cord-012418-6ralcn8p	318	29	response	response	NN
cord-012418-6ralcn8p	318	30	[	[	-LRB-
cord-012418-6ralcn8p	318	31	146	146	CD
cord-012418-6ralcn8p	318	32	]	]	-RRB-
cord-012418-6ralcn8p	318	33	.	.	.
cord-012418-6ralcn8p	319	1	SENP2	SENP2	NNP
cord-012418-6ralcn8p	319	2	targets	target	VBZ
cord-012418-6ralcn8p	319	3	wild	wild	JJ
cord-012418-6ralcn8p	319	4	-	-	HYPH
cord-012418-6ralcn8p	319	5	type	type	NN
cord-012418-6ralcn8p	319	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	319	7	as	as	RB
cord-012418-6ralcn8p	319	8	well	well	RB
cord-012418-6ralcn8p	319	9	as	as	IN
cord-012418-6ralcn8p	319	10	the	the	DT
cord-012418-6ralcn8p	319	11	constitutively	constitutively	RB
cord-012418-6ralcn8p	319	12	active	active	JJ
cord-012418-6ralcn8p	319	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	319	14	-	-	HYPH
cord-012418-6ralcn8p	319	15	5D	5D	NNP
cord-012418-6ralcn8p	319	16	mutant	mutant	NN
cord-012418-6ralcn8p	319	17	,	,	,
cord-012418-6ralcn8p	319	18	suggesting	suggest	VBG
cord-012418-6ralcn8p	319	19	that	that	IN
cord-012418-6ralcn8p	319	20	the	the	DT
cord-012418-6ralcn8p	319	21	SUMOylation	sumoylation	NN
cord-012418-6ralcn8p	319	22	initially	initially	RB
cord-012418-6ralcn8p	319	23	masks	mask	VBZ
cord-012418-6ralcn8p	319	24	the	the	DT
cord-012418-6ralcn8p	319	25	protein	protein	NN
cord-012418-6ralcn8p	319	26	from	from	IN
cord-012418-6ralcn8p	319	27	degradation	degradation	NN
cord-012418-6ralcn8p	319	28	to	to	TO
cord-012418-6ralcn8p	319	29	prolong	prolong	VB
cord-012418-6ralcn8p	319	30	its	-PRON-	PRP$
cord-012418-6ralcn8p	319	31	activity	activity	NN
cord-012418-6ralcn8p	319	32	but	but	CC
cord-012418-6ralcn8p	319	33	that	that	IN
cord-012418-6ralcn8p	319	34	this	this	DT
cord-012418-6ralcn8p	319	35	modification	modification	NN
cord-012418-6ralcn8p	319	36	is	be	VBZ
cord-012418-6ralcn8p	319	37	constantly	constantly	RB
cord-012418-6ralcn8p	319	38	countered	counter	VBN
cord-012418-6ralcn8p	319	39	by	by	IN
cord-012418-6ralcn8p	319	40	SENP2	senp2	JJ
cord-012418-6ralcn8p	319	41	activity	activity	NN
cord-012418-6ralcn8p	319	42	.	.	.
cord-012418-6ralcn8p	320	1	In	in	IN
cord-012418-6ralcn8p	320	2	addition	addition	NN
cord-012418-6ralcn8p	320	3	,	,	,
cord-012418-6ralcn8p	320	4	stimulus	stimulus	NN
cord-012418-6ralcn8p	320	5	-	-	HYPH
cord-012418-6ralcn8p	320	6	induced	induce	VBN
cord-012418-6ralcn8p	320	7	SUMOylation	sumoylation	NN
cord-012418-6ralcn8p	320	8	of	of	IN
cord-012418-6ralcn8p	320	9	murine	murine	JJ
cord-012418-6ralcn8p	320	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	320	11	at	at	IN
cord-012418-6ralcn8p	320	12	K152	K152	NNP
cord-012418-6ralcn8p	320	13	was	be	VBD
cord-012418-6ralcn8p	320	14	reported	report	VBN
cord-012418-6ralcn8p	320	15	to	to	TO
cord-012418-6ralcn8p	320	16	attenuate	attenuate	VB
cord-012418-6ralcn8p	320	17	the	the	DT
cord-012418-6ralcn8p	320	18	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	320	19	response	response	NN
cord-012418-6ralcn8p	320	20	irrespective	irrespective	RB
cord-012418-6ralcn8p	320	21	of	of	IN
cord-012418-6ralcn8p	320	22	the	the	DT
cord-012418-6ralcn8p	320	23	protein	protein	NN
cord-012418-6ralcn8p	320	24	's	's	POS
cord-012418-6ralcn8p	320	25	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	320	26	status	status	NN
cord-012418-6ralcn8p	320	27	,	,	,
cord-012418-6ralcn8p	320	28	though	though	IN
cord-012418-6ralcn8p	320	29	the	the	DT
cord-012418-6ralcn8p	320	30	mediating	mediate	VBG
cord-012418-6ralcn8p	320	31	proteins	protein	NNS
cord-012418-6ralcn8p	320	32	are	be	VBP
cord-012418-6ralcn8p	320	33	unknown	unknown	JJ
cord-012418-6ralcn8p	320	34	[	[	-LRB-
cord-012418-6ralcn8p	320	35	147	147	CD
cord-012418-6ralcn8p	320	36	]	]	-RRB-
cord-012418-6ralcn8p	320	37	.	.	.
cord-012418-6ralcn8p	321	1	Regulation	regulation	NN
cord-012418-6ralcn8p	321	2	of	of	IN
cord-012418-6ralcn8p	321	3	auto	auto	NN
cord-012418-6ralcn8p	321	4	-	-	HYPH
cord-012418-6ralcn8p	321	5	inhibition	inhibition	NN
cord-012418-6ralcn8p	321	6	aside	aside	RB
cord-012418-6ralcn8p	321	7	,	,	,
cord-012418-6ralcn8p	321	8	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	321	9	of	of	IN
cord-012418-6ralcn8p	321	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	321	11	can	can	MD
cord-012418-6ralcn8p	321	12	contribute	contribute	VB
cord-012418-6ralcn8p	321	13	to	to	IN
cord-012418-6ralcn8p	321	14	the	the	DT
cord-012418-6ralcn8p	321	15	down	down	JJ
cord-012418-6ralcn8p	321	16	-	-	HYPH
cord-012418-6ralcn8p	321	17	regulation	regulation	NN
cord-012418-6ralcn8p	321	18	of	of	IN
cord-012418-6ralcn8p	321	19	its	-PRON-	PRP$
cord-012418-6ralcn8p	321	20	activity	activity	NN
cord-012418-6ralcn8p	321	21	also	also	RB
cord-012418-6ralcn8p	321	22	at	at	IN
cord-012418-6ralcn8p	321	23	subsequent	subsequent	JJ
cord-012418-6ralcn8p	321	24	steps	step	NNS
cord-012418-6ralcn8p	321	25	.	.	.
cord-012418-6ralcn8p	322	1	When	when	WRB
cord-012418-6ralcn8p	322	2	screening	screen	VBG
cord-012418-6ralcn8p	322	3	the	the	DT
cord-012418-6ralcn8p	322	4	human	human	JJ
cord-012418-6ralcn8p	322	5	kinome	kinome	NN
cord-012418-6ralcn8p	322	6	for	for	IN
cord-012418-6ralcn8p	322	7	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	322	8	events	event	NNS
cord-012418-6ralcn8p	322	9	during	during	IN
cord-012418-6ralcn8p	322	10	nucleic	nucleic	JJ
cord-012418-6ralcn8p	322	11	acid	acid	NN
cord-012418-6ralcn8p	322	12	sensing	sensing	NN
cord-012418-6ralcn8p	322	13	,	,	,
cord-012418-6ralcn8p	322	14	Meng	Meng	NNP
cord-012418-6ralcn8p	322	15	and	and	CC
cord-012418-6ralcn8p	322	16	colleagues	colleague	NNS
cord-012418-6ralcn8p	322	17	identified	identify	VBD
cord-012418-6ralcn8p	322	18	mammalian	mammalian	JJ
cord-012418-6ralcn8p	322	19	sterile	sterile	JJ
cord-012418-6ralcn8p	322	20	20-like	20-like	CD
cord-012418-6ralcn8p	322	21	kinase	kinase	NN
cord-012418-6ralcn8p	322	22	1	1	CD
cord-012418-6ralcn8p	323	1	(	(	-LRB-
cord-012418-6ralcn8p	323	2	Mst1	Mst1	NNP
cord-012418-6ralcn8p	323	3	,	,	,
cord-012418-6ralcn8p	323	4	also	also	RB
cord-012418-6ralcn8p	323	5	STK4	STK4	NNP
cord-012418-6ralcn8p	323	6	)	)	-RRB-
cord-012418-6ralcn8p	323	7	as	as	IN
cord-012418-6ralcn8p	323	8	an	an	DT
cord-012418-6ralcn8p	323	9	inhibitor	inhibitor	NN
cord-012418-6ralcn8p	323	10	of	of	IN
cord-012418-6ralcn8p	323	11	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	323	12	promoter	promoter	NN
cord-012418-6ralcn8p	323	13	induction	induction	NN
cord-012418-6ralcn8p	323	14	and	and	CC
cord-012418-6ralcn8p	323	15	confirmed	confirm	VBD
cord-012418-6ralcn8p	323	16	the	the	DT
cord-012418-6ralcn8p	323	17	effect	effect	NN
cord-012418-6ralcn8p	323	18	of	of	IN
cord-012418-6ralcn8p	323	19	Mst1	Mst1	NNP
cord-012418-6ralcn8p	323	20	in	in	IN
cord-012418-6ralcn8p	323	21	knockout	knockout	NN
cord-012418-6ralcn8p	323	22	mice	mouse	NNS
cord-012418-6ralcn8p	323	23	[	[	-LRB-
cord-012418-6ralcn8p	323	24	148	148	CD
cord-012418-6ralcn8p	323	25	]	]	-RRB-
cord-012418-6ralcn8p	323	26	.	.	.
cord-012418-6ralcn8p	324	1	Mst1	Mst1	NNP
cord-012418-6ralcn8p	324	2	suppresses	suppress	VBZ
cord-012418-6ralcn8p	324	3	activation	activation	NN
cord-012418-6ralcn8p	324	4	of	of	IN
cord-012418-6ralcn8p	324	5	TBK1	TBK1	NNP
cord-012418-6ralcn8p	324	6	and	and	CC
cord-012418-6ralcn8p	324	7	IKKε	IKKε	NNS
cord-012418-6ralcn8p	324	8	and	and	CC
cord-012418-6ralcn8p	324	9	thereby	thereby	RB
cord-012418-6ralcn8p	324	10	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	324	11	the	the	DT
cord-012418-6ralcn8p	324	12	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	324	13	-	-	HYPH
cord-012418-6ralcn8p	324	14	dependent	dependent	JJ
cord-012418-6ralcn8p	324	15	activation	activation	NN
cord-012418-6ralcn8p	324	16	of	of	IN
cord-012418-6ralcn8p	324	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	324	18	,	,	,
cord-012418-6ralcn8p	324	19	but	but	CC
cord-012418-6ralcn8p	324	20	it	-PRON-	PRP
cord-012418-6ralcn8p	324	21	also	also	RB
cord-012418-6ralcn8p	324	22	targets	target	VBZ
cord-012418-6ralcn8p	324	23	IRF3	IRF3	NNP
cord-012418-6ralcn8p	324	24	directly	directly	RB
cord-012418-6ralcn8p	324	25	for	for	IN
cord-012418-6ralcn8p	324	26	deactivation	deactivation	NN
cord-012418-6ralcn8p	324	27	by	by	IN
cord-012418-6ralcn8p	324	28	phosphorylating	phosphorylate	VBG
cord-012418-6ralcn8p	324	29	two	two	CD
cord-012418-6ralcn8p	324	30	sites	site	NNS
cord-012418-6ralcn8p	324	31	of	of	IN
cord-012418-6ralcn8p	324	32	IRF3	IRF3	NNP
cord-012418-6ralcn8p	324	33	(	(	-LRB-
cord-012418-6ralcn8p	324	34	T75	T75	NNP
cord-012418-6ralcn8p	324	35	,	,	,
cord-012418-6ralcn8p	324	36	T253	t253	ADD
cord-012418-6ralcn8p	324	37	)	)	-RRB-
cord-012418-6ralcn8p	324	38	.	.	.
cord-012418-6ralcn8p	325	1	Demonstrating	demonstrate	VBG
cord-012418-6ralcn8p	325	2	that	that	IN
cord-012418-6ralcn8p	325	3	this	this	DT
cord-012418-6ralcn8p	325	4	effect	effect	NN
cord-012418-6ralcn8p	325	5	is	be	VBZ
cord-012418-6ralcn8p	325	6	independent	independent	JJ
cord-012418-6ralcn8p	325	7	of	of	IN
cord-012418-6ralcn8p	325	8	the	the	DT
cord-012418-6ralcn8p	325	9	inhibition	inhibition	NN
cord-012418-6ralcn8p	325	10	of	of	IN
cord-012418-6ralcn8p	325	11	the	the	DT
cord-012418-6ralcn8p	325	12	upstream	upstream	JJ
cord-012418-6ralcn8p	325	13	kinases	kinase	NNS
cord-012418-6ralcn8p	325	14	by	by	IN
cord-012418-6ralcn8p	325	15	Mst1	Mst1	NNP
cord-012418-6ralcn8p	325	16	,	,	,
cord-012418-6ralcn8p	325	17	introduction	introduction	NN
cord-012418-6ralcn8p	325	18	of	of	IN
cord-012418-6ralcn8p	325	19	a	a	DT
cord-012418-6ralcn8p	325	20	single	single	JJ
cord-012418-6ralcn8p	325	21	phosphomimetic	phosphomimetic	JJ
cord-012418-6ralcn8p	325	22	mutation	mutation	NN
cord-012418-6ralcn8p	325	23	,	,	,
cord-012418-6ralcn8p	325	24	T253D	T253D	NNP
cord-012418-6ralcn8p	325	25	,	,	,
cord-012418-6ralcn8p	325	26	is	be	VBZ
cord-012418-6ralcn8p	325	27	sufficient	sufficient	JJ
cord-012418-6ralcn8p	325	28	to	to	TO
cord-012418-6ralcn8p	325	29	impair	impair	VB
cord-012418-6ralcn8p	325	30	the	the	DT
cord-012418-6ralcn8p	325	31	ability	ability	NN
cord-012418-6ralcn8p	325	32	of	of	IN
cord-012418-6ralcn8p	325	33	the	the	DT
cord-012418-6ralcn8p	325	34	constitutively	constitutively	RB
cord-012418-6ralcn8p	325	35	active	active	JJ
cord-012418-6ralcn8p	325	36	IRF3	IRF3	NNP
cord-012418-6ralcn8p	325	37	-	-	HYPH
cord-012418-6ralcn8p	325	38	5D	5D	NNP
cord-012418-6ralcn8p	325	39	to	to	TO
cord-012418-6ralcn8p	325	40	dimerise	dimerise	VB
cord-012418-6ralcn8p	325	41	after	after	IN
cord-012418-6ralcn8p	325	42	stimulation	stimulation	NN
cord-012418-6ralcn8p	325	43	[	[	-LRB-
cord-012418-6ralcn8p	325	44	148	148	CD
cord-012418-6ralcn8p	325	45	]	]	-RRB-
cord-012418-6ralcn8p	325	46	.	.	.
cord-012418-6ralcn8p	326	1	A	a	DT
cord-012418-6ralcn8p	326	2	further	further	JJ
cord-012418-6ralcn8p	326	3	level	level	NN
cord-012418-6ralcn8p	326	4	of	of	IN
cord-012418-6ralcn8p	326	5	negative	negative	JJ
cord-012418-6ralcn8p	326	6	regulation	regulation	NN
cord-012418-6ralcn8p	326	7	of	of	IN
cord-012418-6ralcn8p	326	8	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	326	9	signalling	signal	VBG
cord-012418-6ralcn8p	326	10	is	be	VBZ
cord-012418-6ralcn8p	326	11	imposed	impose	VBN
cord-012418-6ralcn8p	326	12	by	by	IN
cord-012418-6ralcn8p	326	13	the	the	DT
cord-012418-6ralcn8p	326	14	ubiquitously	ubiquitously	RB
cord-012418-6ralcn8p	326	15	expressed	express	VBN
cord-012418-6ralcn8p	326	16	Fas	Fas	NNP
cord-012418-6ralcn8p	326	17	-	-	HYPH
cord-012418-6ralcn8p	326	18	associated	associate	VBN
cord-012418-6ralcn8p	326	19	factor	factor	NN
cord-012418-6ralcn8p	326	20	1	1	CD
cord-012418-6ralcn8p	326	21	(	(	-LRB-
cord-012418-6ralcn8p	326	22	FAF1	FAF1	NNP
cord-012418-6ralcn8p	326	23	)	)	-RRB-
cord-012418-6ralcn8p	326	24	,	,	,
cord-012418-6ralcn8p	326	25	which	which	WDT
cord-012418-6ralcn8p	326	26	interacts	interact	VBZ
cord-012418-6ralcn8p	326	27	with	with	IN
cord-012418-6ralcn8p	326	28	importin	importin	NNP
cord-012418-6ralcn8p	326	29	5	5	CD
cord-012418-6ralcn8p	327	1	(	(	-LRB-
cord-012418-6ralcn8p	327	2	IOP5	IOP5	NNP
cord-012418-6ralcn8p	327	3	,	,	,
cord-012418-6ralcn8p	327	4	also	also	RB
cord-012418-6ralcn8p	327	5	KPNB3	kpnb3	RB
cord-012418-6ralcn8p	327	6	)	)	-RRB-
cord-012418-6ralcn8p	327	7	in	in	IN
cord-012418-6ralcn8p	327	8	resting	rest	VBG
cord-012418-6ralcn8p	327	9	as	as	RB
cord-012418-6ralcn8p	327	10	well	well	RB
cord-012418-6ralcn8p	327	11	as	as	IN
cord-012418-6ralcn8p	327	12	stimulated	stimulate	VBN
cord-012418-6ralcn8p	327	13	cells	cell	NNS
cord-012418-6ralcn8p	327	14	[	[	-LRB-
cord-012418-6ralcn8p	327	15	149	149	CD
cord-012418-6ralcn8p	327	16	]	]	-RRB-
cord-012418-6ralcn8p	327	17	.	.	.
cord-012418-6ralcn8p	328	1	After	after	IN
cord-012418-6ralcn8p	328	2	viral	viral	JJ
cord-012418-6ralcn8p	328	3	stimulation	stimulation	NN
cord-012418-6ralcn8p	328	4	,	,	,
cord-012418-6ralcn8p	328	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	328	6	increasingly	increasingly	RB
cord-012418-6ralcn8p	328	7	associates	associate	VBZ
cord-012418-6ralcn8p	328	8	with	with	IN
cord-012418-6ralcn8p	328	9	IPO5	IPO5	NNP
cord-012418-6ralcn8p	328	10	for	for	IN
cord-012418-6ralcn8p	328	11	nuclear	nuclear	JJ
cord-012418-6ralcn8p	328	12	import	import	NN
cord-012418-6ralcn8p	328	13	,	,	,
cord-012418-6ralcn8p	328	14	but	but	CC
cord-012418-6ralcn8p	328	15	this	this	DT
cord-012418-6ralcn8p	328	16	is	be	VBZ
cord-012418-6ralcn8p	328	17	dampened	dampen	VBN
cord-012418-6ralcn8p	328	18	by	by	IN
cord-012418-6ralcn8p	328	19	the	the	DT
cord-012418-6ralcn8p	328	20	FAF1-IPO5	FAF1-IPO5	NNP
cord-012418-6ralcn8p	328	21	interaction	interaction	NN
cord-012418-6ralcn8p	328	22	which	which	WDT
cord-012418-6ralcn8p	328	23	consequently	consequently	RB
cord-012418-6ralcn8p	328	24	reduces	reduce	VBZ
cord-012418-6ralcn8p	328	25	the	the	DT
cord-012418-6ralcn8p	328	26	translocation	translocation	NN
cord-012418-6ralcn8p	328	27	of	of	IN
cord-012418-6ralcn8p	328	28	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	328	29	IRF3	IRF3	NNP
cord-012418-6ralcn8p	328	30	and	and	CC
cord-012418-6ralcn8p	328	31	the	the	DT
cord-012418-6ralcn8p	328	32	induction	induction	NN
cord-012418-6ralcn8p	328	33	of	of	IN
cord-012418-6ralcn8p	328	34	IFNB1	ifnb1	DT
cord-012418-6ralcn8p	328	35	expression	expression	NN
cord-012418-6ralcn8p	328	36	.	.	.
cord-012418-6ralcn8p	329	1	In	in	IN
cord-012418-6ralcn8p	329	2	the	the	DT
cord-012418-6ralcn8p	329	3	nucleus	nucleus	NN
cord-012418-6ralcn8p	329	4	,	,	,
cord-012418-6ralcn8p	329	5	formation	formation	NN
cord-012418-6ralcn8p	329	6	of	of	IN
cord-012418-6ralcn8p	329	7	the	the	DT
cord-012418-6ralcn8p	329	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	329	9	/	/	SYM
cord-012418-6ralcn8p	329	10	p300	p300	NNP
cord-012418-6ralcn8p	329	11	complex	complex	NN
cord-012418-6ralcn8p	329	12	and	and	CC
cord-012418-6ralcn8p	329	13	p300-mediated	p300-mediated	JJ
cord-012418-6ralcn8p	329	14	acetylation	acetylation	NN
cord-012418-6ralcn8p	329	15	of	of	IN
cord-012418-6ralcn8p	329	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	329	17	after	after	IN
cord-012418-6ralcn8p	329	18	virus	virus	NN
cord-012418-6ralcn8p	329	19	infection	infection	NN
cord-012418-6ralcn8p	329	20	is	be	VBZ
cord-012418-6ralcn8p	329	21	assisted	assist	VBN
cord-012418-6ralcn8p	329	22	by	by	IN
cord-012418-6ralcn8p	329	23	bromodomain	bromodomain	NN
cord-012418-6ralcn8p	329	24	-	-	HYPH
cord-012418-6ralcn8p	329	25	containing	contain	VBG
cord-012418-6ralcn8p	329	26	3	3	CD
cord-012418-6ralcn8p	329	27	(	(	-LRB-
cord-012418-6ralcn8p	329	28	Brd3	Brd3	NNP
cord-012418-6ralcn8p	329	29	)	)	-RRB-
cord-012418-6ralcn8p	329	30	[	[	-LRB-
cord-012418-6ralcn8p	329	31	150	150	CD
cord-012418-6ralcn8p	329	32	]	]	-RRB-
cord-012418-6ralcn8p	329	33	.	.	.
cord-012418-6ralcn8p	330	1	Generally	generally	RB
cord-012418-6ralcn8p	330	2	,	,	,
cord-012418-6ralcn8p	330	3	interaction	interaction	NN
cord-012418-6ralcn8p	330	4	of	of	IN
cord-012418-6ralcn8p	330	5	Brd3	Brd3	NNP
cord-012418-6ralcn8p	330	6	with	with	IN
cord-012418-6ralcn8p	330	7	p300	p300	NNP
cord-012418-6ralcn8p	330	8	promotes	promote	VBZ
cord-012418-6ralcn8p	330	9	recruitment	recruitment	NN
cord-012418-6ralcn8p	330	10	of	of	IN
cord-012418-6ralcn8p	330	11	the	the	DT
cord-012418-6ralcn8p	330	12	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	330	13	to	to	IN
cord-012418-6ralcn8p	330	14	the	the	DT
cord-012418-6ralcn8p	330	15	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	330	16	enhancer	enhancer	NN
cord-012418-6ralcn8p	330	17	and	and	CC
cord-012418-6ralcn8p	330	18	facilitates	facilitate	VBZ
cord-012418-6ralcn8p	330	19	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	330	20	transcription	transcription	NN
cord-012418-6ralcn8p	330	21	.	.	.
cord-012418-6ralcn8p	331	1	This	this	DT
cord-012418-6ralcn8p	331	2	supporting	support	VBG
cord-012418-6ralcn8p	331	3	mechanism	mechanism	NN
cord-012418-6ralcn8p	331	4	seems	seem	VBZ
cord-012418-6ralcn8p	331	5	to	to	TO
cord-012418-6ralcn8p	331	6	come	come	VB
cord-012418-6ralcn8p	331	7	with	with	IN
cord-012418-6ralcn8p	331	8	a	a	DT
cord-012418-6ralcn8p	331	9	time	time	NN
cord-012418-6ralcn8p	331	10	limit	limit	NN
cord-012418-6ralcn8p	331	11	,	,	,
cord-012418-6ralcn8p	331	12	however	however	RB
cord-012418-6ralcn8p	331	13	,	,	,
cord-012418-6ralcn8p	331	14	as	as	IN
cord-012418-6ralcn8p	331	15	analysis	analysis	NN
cord-012418-6ralcn8p	331	16	in	in	IN
cord-012418-6ralcn8p	331	17	macrophages	macrophage	NNS
cord-012418-6ralcn8p	331	18	revealed	reveal	VBD
cord-012418-6ralcn8p	331	19	that	that	IN
cord-012418-6ralcn8p	331	20	viral	viral	JJ
cord-012418-6ralcn8p	331	21	stimulation	stimulation	NN
cord-012418-6ralcn8p	331	22	specifically	specifically	RB
cord-012418-6ralcn8p	331	23	down	down	RB
cord-012418-6ralcn8p	331	24	-	-	HYPH
cord-012418-6ralcn8p	331	25	regulates	regulate	NNS
cord-012418-6ralcn8p	331	26	Brd3	brd3	JJ
cord-012418-6ralcn8p	331	27	abundance	abundance	NN
cord-012418-6ralcn8p	331	28	and	and	CC
cord-012418-6ralcn8p	331	29	thereby	thereby	RB
cord-012418-6ralcn8p	331	30	terminates	terminate	VBZ
cord-012418-6ralcn8p	331	31	its	-PRON-	PRP$
cord-012418-6ralcn8p	331	32	support	support	NN
cord-012418-6ralcn8p	331	33	[	[	-LRB-
cord-012418-6ralcn8p	331	34	150	150	CD
cord-012418-6ralcn8p	331	35	]	]	-RRB-
cord-012418-6ralcn8p	331	36	.	.	.
cord-012418-6ralcn8p	332	1	Similarly	similarly	RB
cord-012418-6ralcn8p	332	2	,	,	,
cord-012418-6ralcn8p	332	3	Zhang	Zhang	NNP
cord-012418-6ralcn8p	332	4	and	and	CC
cord-012418-6ralcn8p	332	5	colleagues	colleague	NNS
cord-012418-6ralcn8p	332	6	recently	recently	RB
cord-012418-6ralcn8p	332	7	reported	report	VBD
cord-012418-6ralcn8p	332	8	stimulation	stimulation	NN
cord-012418-6ralcn8p	332	9	-	-	HYPH
cord-012418-6ralcn8p	332	10	induced	induce	VBN
cord-012418-6ralcn8p	332	11	non	non	JJ
cord-012418-6ralcn8p	332	12	-	-	JJ
cord-012418-6ralcn8p	332	13	canonical	canonical	JJ
cord-012418-6ralcn8p	332	14	K6-linked	k6-linke	VBN
cord-012418-6ralcn8p	332	15	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	332	16	at	at	IN
cord-012418-6ralcn8p	332	17	three	three	CD
cord-012418-6ralcn8p	332	18	positions	position	NNS
cord-012418-6ralcn8p	332	19	in	in	IN
cord-012418-6ralcn8p	332	20	the	the	DT
cord-012418-6ralcn8p	332	21	DBD	DBD	NNP
cord-012418-6ralcn8p	332	22	of	of	IN
cord-012418-6ralcn8p	332	23	IRF3	IRF3	NNP
cord-012418-6ralcn8p	332	24	(	(	-LRB-
cord-012418-6ralcn8p	332	25	K39	K39	NNP
cord-012418-6ralcn8p	332	26	,	,	,
cord-012418-6ralcn8p	332	27	K98	K98	NNP
cord-012418-6ralcn8p	332	28	,	,	,
cord-012418-6ralcn8p	332	29	K105	K105	NNP
cord-012418-6ralcn8p	332	30	)	)	-RRB-
cord-012418-6ralcn8p	332	31	and	and	CC
cord-012418-6ralcn8p	332	32	demonstrated	demonstrate	VBD
cord-012418-6ralcn8p	332	33	that	that	IN
cord-012418-6ralcn8p	332	34	this	this	DT
cord-012418-6ralcn8p	332	35	modification	modification	NN
cord-012418-6ralcn8p	332	36	is	be	VBZ
cord-012418-6ralcn8p	332	37	essential	essential	JJ
cord-012418-6ralcn8p	332	38	for	for	IN
cord-012418-6ralcn8p	332	39	the	the	DT
cord-012418-6ralcn8p	332	40	DNA	dna	NN
cord-012418-6ralcn8p	332	41	-	-	HYPH
cord-012418-6ralcn8p	332	42	binding	bind	VBG
cord-012418-6ralcn8p	332	43	capacity	capacity	NN
cord-012418-6ralcn8p	332	44	of	of	IN
cord-012418-6ralcn8p	332	45	IRF3	IRF3	NNP
cord-012418-6ralcn8p	332	46	in	in	IN
cord-012418-6ralcn8p	332	47	macrophages	macrophage	NNS
cord-012418-6ralcn8p	332	48	and	and	CC
cord-012418-6ralcn8p	332	49	in	in	IN
cord-012418-6ralcn8p	332	50	HEK293	HEK293	NNP
cord-012418-6ralcn8p	332	51	T	t	NN
cord-012418-6ralcn8p	332	52	cells	cell	NNS
cord-012418-6ralcn8p	332	53	[	[	-LRB-
cord-012418-6ralcn8p	332	54	151	151	CD
cord-012418-6ralcn8p	332	55	]	]	-RRB-
cord-012418-6ralcn8p	332	56	.	.	.
cord-012418-6ralcn8p	333	1	As	as	IN
cord-012418-6ralcn8p	333	2	a	a	DT
cord-012418-6ralcn8p	333	3	counter	counter	JJ
cord-012418-6ralcn8p	333	4	measure	measure	NN
cord-012418-6ralcn8p	333	5	,	,	,
cord-012418-6ralcn8p	333	6	virus	virus	NN
cord-012418-6ralcn8p	333	7	-	-	HYPH
cord-012418-6ralcn8p	333	8	infected	infect	VBN
cord-012418-6ralcn8p	333	9	cells	cell	NNS
cord-012418-6ralcn8p	333	10	additionally	additionally	RB
cord-012418-6ralcn8p	333	11	up	up	RB
cord-012418-6ralcn8p	333	12	-	-	HYPH
cord-012418-6ralcn8p	333	13	regulate	regulate	VB
cord-012418-6ralcn8p	333	14	expression	expression	NN
cord-012418-6ralcn8p	333	15	of	of	IN
cord-012418-6ralcn8p	333	16	the	the	DT
cord-012418-6ralcn8p	333	17	ovarian	ovarian	JJ
cord-012418-6ralcn8p	333	18	tumour	tumour	NN
cord-012418-6ralcn8p	333	19	domain	domain	NN
cord-012418-6ralcn8p	333	20	-	-	HYPH
cord-012418-6ralcn8p	333	21	containing	contain	VBG
cord-012418-6ralcn8p	333	22	deubiquitinase	deubiquitinase	NN
cord-012418-6ralcn8p	333	23	(	(	-LRB-
cord-012418-6ralcn8p	333	24	OTUD1	OTUD1	NNP
cord-012418-6ralcn8p	333	25	)	)	-RRB-
cord-012418-6ralcn8p	333	26	,	,	,
cord-012418-6ralcn8p	333	27	and	and	CC
cord-012418-6ralcn8p	333	28	OTUD1	OTUD1	NNP
cord-012418-6ralcn8p	333	29	then	then	RB
cord-012418-6ralcn8p	333	30	removes	remove	VBZ
cord-012418-6ralcn8p	333	31	this	this	DT
cord-012418-6ralcn8p	333	32	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	333	33	from	from	IN
cord-012418-6ralcn8p	333	34	IRF3	IRF3	NNP
cord-012418-6ralcn8p	333	35	,	,	,
cord-012418-6ralcn8p	333	36	resulting	result	VBG
cord-012418-6ralcn8p	333	37	in	in	IN
cord-012418-6ralcn8p	333	38	reduced	reduce	VBN
cord-012418-6ralcn8p	333	39	IRF3-binding	irf3-binding	NN
cord-012418-6ralcn8p	333	40	to	to	IN
cord-012418-6ralcn8p	333	41	the	the	DT
cord-012418-6ralcn8p	333	42	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	333	43	promoter	promoter	NN
cord-012418-6ralcn8p	333	44	region	region	NN
cord-012418-6ralcn8p	333	45	at	at	IN
cord-012418-6ralcn8p	333	46	later	later	JJ
cord-012418-6ralcn8p	333	47	times	time	NNS
cord-012418-6ralcn8p	333	48	[	[	-LRB-
cord-012418-6ralcn8p	333	49	151	151	CD
cord-012418-6ralcn8p	333	50	]	]	-RRB-
cord-012418-6ralcn8p	333	51	.	.	.
cord-012418-6ralcn8p	334	1	To	to	TO
cord-012418-6ralcn8p	334	2	allow	allow	VB
cord-012418-6ralcn8p	334	3	moderation	moderation	NN
cord-012418-6ralcn8p	334	4	of	of	IN
cord-012418-6ralcn8p	334	5	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	334	6	assembly	assembly	NN
cord-012418-6ralcn8p	334	7	after	after	IN
cord-012418-6ralcn8p	334	8	formation	formation	NN
cord-012418-6ralcn8p	334	9	of	of	IN
cord-012418-6ralcn8p	334	10	the	the	DT
cord-012418-6ralcn8p	334	11	active	active	JJ
cord-012418-6ralcn8p	334	12	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	334	13	/	/	SYM
cord-012418-6ralcn8p	334	14	p300	p300	NNP
cord-012418-6ralcn8p	334	15	complex	complex	NN
cord-012418-6ralcn8p	334	16	,	,	,
cord-012418-6ralcn8p	334	17	other	other	JJ
cord-012418-6ralcn8p	334	18	DNA	dna	NN
cord-012418-6ralcn8p	334	19	-	-	HYPH
cord-012418-6ralcn8p	334	20	binding	bind	VBG
cord-012418-6ralcn8p	334	21	proteins	protein	NNS
cord-012418-6ralcn8p	334	22	were	be	VBD
cord-012418-6ralcn8p	334	23	reported	report	VBN
cord-012418-6ralcn8p	334	24	to	to	TO
cord-012418-6ralcn8p	334	25	interact	interact	VB
cord-012418-6ralcn8p	334	26	with	with	IN
cord-012418-6ralcn8p	334	27	motifs	motif	NNS
cord-012418-6ralcn8p	334	28	contained	contain	VBN
cord-012418-6ralcn8p	334	29	within	within	IN
cord-012418-6ralcn8p	334	30	the	the	DT
cord-012418-6ralcn8p	334	31	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	334	32	enhancer	enhancer	NN
cord-012418-6ralcn8p	334	33	sequence	sequence	NN
cord-012418-6ralcn8p	334	34	.	.	.
cord-012418-6ralcn8p	335	1	The	the	DT
cord-012418-6ralcn8p	335	2	first	first	JJ
cord-012418-6ralcn8p	335	3	IRF	IRF	NNP
cord-012418-6ralcn8p	335	4	-	-	HYPH
cord-012418-6ralcn8p	335	5	E	E	NNP
cord-012418-6ralcn8p	335	6	overlaps	overlap	VBZ
cord-012418-6ralcn8p	335	7	with	with	IN
cord-012418-6ralcn8p	335	8	a	a	DT
cord-012418-6ralcn8p	335	9	consensus	consensus	NN
cord-012418-6ralcn8p	335	10	binding	bind	VBG
cord-012418-6ralcn8p	335	11	site	site	NN
cord-012418-6ralcn8p	335	12	for	for	IN
cord-012418-6ralcn8p	335	13	an	an	DT
cord-012418-6ralcn8p	335	14	activator	activator	NN
cord-012418-6ralcn8p	335	15	of	of	IN
cord-012418-6ralcn8p	335	16	pro	pro	JJ
cord-012418-6ralcn8p	335	17	-	-	JJ
cord-012418-6ralcn8p	335	18	inflammatory	inflammatory	JJ
cord-012418-6ralcn8p	335	19	responses	response	NNS
cord-012418-6ralcn8p	335	20	in	in	IN
cord-012418-6ralcn8p	335	21	macrophages	macrophage	NNS
cord-012418-6ralcn8p	335	22	,	,	,
cord-012418-6ralcn8p	335	23	NFAT5	NFAT5	NNP
cord-012418-6ralcn8p	335	24	(	(	-LRB-
cord-012418-6ralcn8p	335	25	nuclear	nuclear	JJ
cord-012418-6ralcn8p	335	26	factor	factor	NN
cord-012418-6ralcn8p	335	27	of	of	IN
cord-012418-6ralcn8p	335	28	activated	activate	VBN
cord-012418-6ralcn8p	335	29	T	T	NNP
cord-012418-6ralcn8p	335	30	cells	cell	NNS
cord-012418-6ralcn8p	335	31	5	5	CD
cord-012418-6ralcn8p	335	32	)	)	-RRB-
cord-012418-6ralcn8p	335	33	,	,	,
cord-012418-6ralcn8p	335	34	which	which	WDT
cord-012418-6ralcn8p	335	35	is	be	VBZ
cord-012418-6ralcn8p	335	36	conserved	conserve	VBN
cord-012418-6ralcn8p	335	37	between	between	IN
cord-012418-6ralcn8p	335	38	human	human	NN
cord-012418-6ralcn8p	335	39	and	and	CC
cord-012418-6ralcn8p	335	40	mouse	mouse	NN
cord-012418-6ralcn8p	335	41	promoter	promoter	NN
cord-012418-6ralcn8p	335	42	sequences	sequence	NNS
cord-012418-6ralcn8p	335	43	[	[	-LRB-
cord-012418-6ralcn8p	335	44	152	152	CD
cord-012418-6ralcn8p	335	45	]	]	-RRB-
cord-012418-6ralcn8p	335	46	.	.	.
cord-012418-6ralcn8p	336	1	NFAT5	NFAT5	NNP
cord-012418-6ralcn8p	336	2	constitutively	constitutively	RB
cord-012418-6ralcn8p	336	3	forms	form	VBZ
cord-012418-6ralcn8p	336	4	dimers	dimer	NNS
cord-012418-6ralcn8p	336	5	that	that	WDT
cord-012418-6ralcn8p	336	6	can	can	MD
cord-012418-6ralcn8p	336	7	bind	bind	VB
cord-012418-6ralcn8p	336	8	to	to	IN
cord-012418-6ralcn8p	336	9	the	the	DT
cord-012418-6ralcn8p	336	10	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	336	11	enhancer	enhancer	NN
cord-012418-6ralcn8p	336	12	region	region	NN
cord-012418-6ralcn8p	336	13	and	and	CC
cord-012418-6ralcn8p	336	14	competes	compete	VBZ
cord-012418-6ralcn8p	336	15	with	with	IN
cord-012418-6ralcn8p	336	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	336	17	due	due	IN
cord-012418-6ralcn8p	336	18	to	to	IN
cord-012418-6ralcn8p	336	19	the	the	DT
cord-012418-6ralcn8p	336	20	overlapping	overlap	VBG
cord-012418-6ralcn8p	336	21	recognition	recognition	NN
cord-012418-6ralcn8p	336	22	sequence	sequence	NN
cord-012418-6ralcn8p	336	23	,	,	,
cord-012418-6ralcn8p	336	24	resulting	result	VBG
cord-012418-6ralcn8p	336	25	in	in	IN
cord-012418-6ralcn8p	336	26	limited	limited	JJ
cord-012418-6ralcn8p	336	27	recruitment	recruitment	NN
cord-012418-6ralcn8p	336	28	of	of	IN
cord-012418-6ralcn8p	336	29	IRF3	IRF3	NNP
cord-012418-6ralcn8p	336	30	to	to	IN
cord-012418-6ralcn8p	336	31	the	the	DT
cord-012418-6ralcn8p	336	32	enhancer	enhancer	NN
cord-012418-6ralcn8p	336	33	and	and	CC
cord-012418-6ralcn8p	336	34	thus	thus	RB
cord-012418-6ralcn8p	336	35	limited	limited	JJ
cord-012418-6ralcn8p	336	36	promoter	promoter	NN
cord-012418-6ralcn8p	336	37	induction	induction	NN
cord-012418-6ralcn8p	336	38	.	.	.
cord-012418-6ralcn8p	337	1	In	in	IN
cord-012418-6ralcn8p	337	2	a	a	DT
cord-012418-6ralcn8p	337	3	similar	similar	JJ
cord-012418-6ralcn8p	337	4	way	way	NN
cord-012418-6ralcn8p	337	5	,	,	,
cord-012418-6ralcn8p	337	6	the	the	DT
cord-012418-6ralcn8p	337	7	transcription	transcription	NN
cord-012418-6ralcn8p	337	8	regulator	regulator	NN
cord-012418-6ralcn8p	337	9	MAF	MAF	NNP
cord-012418-6ralcn8p	337	10	bZIP	bZIP	VBG
cord-012418-6ralcn8p	337	11	transcription	transcription	NN
cord-012418-6ralcn8p	337	12	factor	factor	NN
cord-012418-6ralcn8p	337	13	B	B	NNP
cord-012418-6ralcn8p	337	14	(	(	-LRB-
cord-012418-6ralcn8p	337	15	MafB	MafB	NNP
cord-012418-6ralcn8p	337	16	)	)	-RRB-
cord-012418-6ralcn8p	337	17	binds	bind	VBZ
cord-012418-6ralcn8p	337	18	in	in	IN
cord-012418-6ralcn8p	337	19	macrophages	macrophage	NNS
cord-012418-6ralcn8p	337	20	to	to	IN
cord-012418-6ralcn8p	337	21	the	the	DT
cord-012418-6ralcn8p	337	22	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	337	23	enhancer	enhancer	NN
cord-012418-6ralcn8p	337	24	sequence	sequence	NN
cord-012418-6ralcn8p	337	25	mediated	mediate	VBN
cord-012418-6ralcn8p	337	26	by	by	IN
cord-012418-6ralcn8p	337	27	AP-1-like	ap-1-like	JJ
cord-012418-6ralcn8p	337	28	sites	site	NNS
cord-012418-6ralcn8p	337	29	[	[	-LRB-
cord-012418-6ralcn8p	337	30	153	153	CD
cord-012418-6ralcn8p	337	31	]	]	-RRB-
cord-012418-6ralcn8p	337	32	.	.	.
cord-012418-6ralcn8p	338	1	In	in	IN
cord-012418-6ralcn8p	338	2	resting	rest	VBG
cord-012418-6ralcn8p	338	3	conditions	condition	NNS
cord-012418-6ralcn8p	338	4	,	,	,
cord-012418-6ralcn8p	338	5	MafB	MafB	NNP
cord-012418-6ralcn8p	338	6	is	be	VBZ
cord-012418-6ralcn8p	338	7	a	a	DT
cord-012418-6ralcn8p	338	8	weak	weak	JJ
cord-012418-6ralcn8p	338	9	positive	positive	JJ
cord-012418-6ralcn8p	338	10	regulator	regulator	NN
cord-012418-6ralcn8p	338	11	of	of	IN
cord-012418-6ralcn8p	338	12	basal	basal	NN
cord-012418-6ralcn8p	338	13	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	338	14	transcription	transcription	NN
cord-012418-6ralcn8p	338	15	.	.	.
cord-012418-6ralcn8p	339	1	Upon	upon	IN
cord-012418-6ralcn8p	339	2	stimulation	stimulation	NN
cord-012418-6ralcn8p	339	3	and	and	CC
cord-012418-6ralcn8p	339	4	activation	activation	NN
cord-012418-6ralcn8p	339	5	of	of	IN
cord-012418-6ralcn8p	339	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	339	7	,	,	,
cord-012418-6ralcn8p	339	8	however	however	RB
cord-012418-6ralcn8p	339	9	,	,	,
cord-012418-6ralcn8p	339	10	it	-PRON-	PRP
cord-012418-6ralcn8p	339	11	impairs	impair	VBZ
cord-012418-6ralcn8p	339	12	the	the	DT
cord-012418-6ralcn8p	339	13	interaction	interaction	NN
cord-012418-6ralcn8p	339	14	between	between	IN
cord-012418-6ralcn8p	339	15	the	the	DT
cord-012418-6ralcn8p	339	16	coactivators	coactivator	NNS
cord-012418-6ralcn8p	339	17	and	and	CC
cord-012418-6ralcn8p	339	18	antagonises	antagonises	NNP
cord-012418-6ralcn8p	339	19	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	339	20	formation	formation	NN
cord-012418-6ralcn8p	339	21	.	.	.
cord-012418-6ralcn8p	340	1	This	this	DT
cord-012418-6ralcn8p	340	2	dual	dual	JJ
cord-012418-6ralcn8p	340	3	role	role	NN
cord-012418-6ralcn8p	340	4	was	be	VBD
cord-012418-6ralcn8p	340	5	suggested	suggest	VBN
cord-012418-6ralcn8p	340	6	to	to	TO
cord-012418-6ralcn8p	340	7	allow	allow	VB
cord-012418-6ralcn8p	340	8	the	the	DT
cord-012418-6ralcn8p	340	9	system	system	NN
cord-012418-6ralcn8p	340	10	to	to	TO
cord-012418-6ralcn8p	340	11	deal	deal	VB
cord-012418-6ralcn8p	340	12	with	with	IN
cord-012418-6ralcn8p	340	13	fluctuations	fluctuation	NNS
cord-012418-6ralcn8p	340	14	in	in	IN
cord-012418-6ralcn8p	340	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	340	16	activity	activity	NN
cord-012418-6ralcn8p	340	17	[	[	-LRB-
cord-012418-6ralcn8p	340	18	153	153	CD
cord-012418-6ralcn8p	340	19	]	]	-RRB-
cord-012418-6ralcn8p	340	20	.	.	.
cord-012418-6ralcn8p	341	1	During	during	IN
cord-012418-6ralcn8p	341	2	the	the	DT
cord-012418-6ralcn8p	341	3	course	course	NN
cord-012418-6ralcn8p	341	4	of	of	IN
cord-012418-6ralcn8p	341	5	the	the	DT
cord-012418-6ralcn8p	341	6	innate	innate	JJ
cord-012418-6ralcn8p	341	7	immune	immune	JJ
cord-012418-6ralcn8p	341	8	response	response	NN
cord-012418-6ralcn8p	341	9	,	,	,
cord-012418-6ralcn8p	341	10	the	the	DT
cord-012418-6ralcn8p	341	11	signal	signal	NN
cord-012418-6ralcn8p	341	12	that	that	WDT
cord-012418-6ralcn8p	341	13	started	start	VBD
cord-012418-6ralcn8p	341	14	it	-PRON-	PRP
cord-012418-6ralcn8p	341	15	all	all	DT
cord-012418-6ralcn8p	341	16	has	have	VBZ
cord-012418-6ralcn8p	341	17	to	to	TO
cord-012418-6ralcn8p	341	18	be	be	VB
cord-012418-6ralcn8p	341	19	switched	switch	VBN
cord-012418-6ralcn8p	341	20	off	off	RP
cord-012418-6ralcn8p	341	21	again	again	RB
cord-012418-6ralcn8p	341	22	to	to	TO
cord-012418-6ralcn8p	341	23	allow	allow	VB
cord-012418-6ralcn8p	341	24	other	other	JJ
cord-012418-6ralcn8p	341	25	messengers	messenger	NNS
cord-012418-6ralcn8p	341	26	to	to	TO
cord-012418-6ralcn8p	341	27	refine	refine	VB
cord-012418-6ralcn8p	341	28	the	the	DT
cord-012418-6ralcn8p	341	29	defence	defence	NN
cord-012418-6ralcn8p	341	30	line	line	NN
cord-012418-6ralcn8p	341	31	.	.	.
cord-012418-6ralcn8p	342	1	The	the	DT
cord-012418-6ralcn8p	342	2	first	first	JJ
cord-012418-6ralcn8p	342	3	mechanism	mechanism	NN
cord-012418-6ralcn8p	342	4	to	to	TO
cord-012418-6ralcn8p	342	5	terminate	terminate	VB
cord-012418-6ralcn8p	342	6	the	the	DT
cord-012418-6ralcn8p	342	7	IRF3-dependent	IRF3-dependent	NNP
cord-012418-6ralcn8p	342	8	response	response	NN
cord-012418-6ralcn8p	342	9	is	be	VBZ
cord-012418-6ralcn8p	342	10	set	set	VBN
cord-012418-6ralcn8p	342	11	into	into	IN
cord-012418-6ralcn8p	342	12	action	action	NN
cord-012418-6ralcn8p	342	13	directly	directly	RB
cord-012418-6ralcn8p	342	14	during	during	IN
cord-012418-6ralcn8p	342	15	the	the	DT
cord-012418-6ralcn8p	342	16	activation	activation	NN
cord-012418-6ralcn8p	342	17	of	of	IN
cord-012418-6ralcn8p	342	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	342	19	by	by	IN
cord-012418-6ralcn8p	342	20	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	342	21	of	of	IN
cord-012418-6ralcn8p	342	22	the	the	DT
cord-012418-6ralcn8p	342	23	C	c	NN
cord-012418-6ralcn8p	342	24	-	-	HYPH
cord-012418-6ralcn8p	342	25	terminal	terminal	NN
cord-012418-6ralcn8p	342	26	AIE	AIE	NNP
cord-012418-6ralcn8p	342	27	[	[	-LRB-
cord-012418-6ralcn8p	342	28	37	37	CD
cord-012418-6ralcn8p	342	29	]	]	-RRB-
cord-012418-6ralcn8p	342	30	.	.	.
cord-012418-6ralcn8p	343	1	In	in	IN
cord-012418-6ralcn8p	343	2	addition	addition	NN
cord-012418-6ralcn8p	343	3	to	to	IN
cord-012418-6ralcn8p	343	4	releasing	release	VBG
cord-012418-6ralcn8p	343	5	the	the	DT
cord-012418-6ralcn8p	343	6	auto	auto	NN
cord-012418-6ralcn8p	343	7	-	-	HYPH
cord-012418-6ralcn8p	343	8	inhibition	inhibition	NN
cord-012418-6ralcn8p	343	9	,	,	,
cord-012418-6ralcn8p	343	10	the	the	DT
cord-012418-6ralcn8p	343	11	modification	modification	NN
cord-012418-6ralcn8p	343	12	represents	represent	VBZ
cord-012418-6ralcn8p	343	13	a	a	DT
cord-012418-6ralcn8p	343	14	signal	signal	NN
cord-012418-6ralcn8p	343	15	for	for	IN
cord-012418-6ralcn8p	343	16	degradation	degradation	NN
cord-012418-6ralcn8p	343	17	of	of	IN
cord-012418-6ralcn8p	343	18	the	the	DT
cord-012418-6ralcn8p	343	19	protein	protein	NN
cord-012418-6ralcn8p	343	20	,	,	,
cord-012418-6ralcn8p	343	21	and	and	CC
cord-012418-6ralcn8p	343	22	so	so	RB
cord-012418-6ralcn8p	343	23	activated	activate	VBD
cord-012418-6ralcn8p	343	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	343	25	has	have	VBZ
cord-012418-6ralcn8p	343	26	a	a	DT
cord-012418-6ralcn8p	343	27	shorter	short	JJR
cord-012418-6ralcn8p	343	28	half	half	JJ
cord-012418-6ralcn8p	343	29	-	-	HYPH
cord-012418-6ralcn8p	343	30	life	life	NN
cord-012418-6ralcn8p	343	31	than	than	IN
cord-012418-6ralcn8p	343	32	the	the	DT
cord-012418-6ralcn8p	343	33	latent	latent	JJ
cord-012418-6ralcn8p	343	34	form	form	NN
cord-012418-6ralcn8p	343	35	[	[	-LRB-
cord-012418-6ralcn8p	343	36	37	37	CD
cord-012418-6ralcn8p	343	37	,	,	,
cord-012418-6ralcn8p	343	38	154	154	CD
cord-012418-6ralcn8p	343	39	]	]	-RRB-
cord-012418-6ralcn8p	343	40	.	.	.
cord-012418-6ralcn8p	344	1	In	in	IN
cord-012418-6ralcn8p	344	2	this	this	DT
cord-012418-6ralcn8p	344	3	way	way	NN
cord-012418-6ralcn8p	344	4	,	,	,
cord-012418-6ralcn8p	344	5	turnover	turnover	NN
cord-012418-6ralcn8p	344	6	of	of	IN
cord-012418-6ralcn8p	344	7	the	the	DT
cord-012418-6ralcn8p	344	8	activated	activate	VBN
cord-012418-6ralcn8p	344	9	protein	protein	NN
cord-012418-6ralcn8p	344	10	by	by	IN
cord-012418-6ralcn8p	344	11	degradation	degradation	NN
cord-012418-6ralcn8p	344	12	rather	rather	RB
cord-012418-6ralcn8p	344	13	than	than	IN
cord-012418-6ralcn8p	344	14	additional	additional	JJ
cord-012418-6ralcn8p	344	15	activation	activation	NN
cord-012418-6ralcn8p	344	16	of	of	IN
cord-012418-6ralcn8p	344	17	repressors	repressor	NNS
cord-012418-6ralcn8p	344	18	is	be	VBZ
cord-012418-6ralcn8p	344	19	an	an	DT
cord-012418-6ralcn8p	344	20	integral	integral	JJ
cord-012418-6ralcn8p	344	21	feature	feature	NN
cord-012418-6ralcn8p	344	22	responsible	responsible	JJ
cord-012418-6ralcn8p	344	23	for	for	IN
cord-012418-6ralcn8p	344	24	ending	end	VBG
cord-012418-6ralcn8p	344	25	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	344	26	expression	expression	NN
cord-012418-6ralcn8p	344	27	[	[	-LRB-
cord-012418-6ralcn8p	344	28	155	155	CD
cord-012418-6ralcn8p	344	29	]	]	-RRB-
cord-012418-6ralcn8p	344	30	.	.	.
cord-012418-6ralcn8p	345	1	Several	several	JJ
cord-012418-6ralcn8p	345	2	molecules	molecule	NNS
cord-012418-6ralcn8p	345	3	have	have	VBP
cord-012418-6ralcn8p	345	4	been	be	VBN
cord-012418-6ralcn8p	345	5	reported	report	VBN
cord-012418-6ralcn8p	345	6	to	to	TO
cord-012418-6ralcn8p	345	7	mediate	mediate	VB
cord-012418-6ralcn8p	345	8	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	345	9	of	of	IN
cord-012418-6ralcn8p	345	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	345	11	in	in	IN
cord-012418-6ralcn8p	345	12	order	order	NN
cord-012418-6ralcn8p	345	13	to	to	TO
cord-012418-6ralcn8p	345	14	induce	induce	VB
cord-012418-6ralcn8p	345	15	its	-PRON-	PRP$
cord-012418-6ralcn8p	345	16	depletion	depletion	NN
cord-012418-6ralcn8p	345	17	after	after	IN
cord-012418-6ralcn8p	345	18	initial	initial	JJ
cord-012418-6ralcn8p	345	19	stimulation	stimulation	NN
cord-012418-6ralcn8p	345	20	[	[	-LRB-
cord-012418-6ralcn8p	345	21	126	126	CD
cord-012418-6ralcn8p	345	22	]	]	-RRB-
cord-012418-6ralcn8p	345	23	:	:	:
cord-012418-6ralcn8p	346	1	Pin1	Pin1	NNP
cord-012418-6ralcn8p	346	2	,	,	,
cord-012418-6ralcn8p	346	3	FoxO1	FoxO1	NNP
cord-012418-6ralcn8p	346	4	[	[	-LRB-
cord-012418-6ralcn8p	346	5	156	156	CD
cord-012418-6ralcn8p	346	6	]	]	-RRB-
cord-012418-6ralcn8p	346	7	,	,	,
cord-012418-6ralcn8p	346	8	TRIM26	TRIM26	NNP
cord-012418-6ralcn8p	346	9	,	,	,
cord-012418-6ralcn8p	346	10	RBCK1	RBCK1	NNP
cord-012418-6ralcn8p	347	1	and	and	CC
cord-012418-6ralcn8p	347	2	TRIM21	trim21	FW
cord-012418-6ralcn8p	347	3	(	(	-LRB-
cord-012418-6ralcn8p	347	4	see	see	VB
cord-012418-6ralcn8p	347	5	above	above	RB
cord-012418-6ralcn8p	347	6	,	,	,
cord-012418-6ralcn8p	347	7	Section	section	NN
cord-012418-6ralcn8p	347	8	4.2	4.2	CD
cord-012418-6ralcn8p	347	9	)	)	-RRB-
cord-012418-6ralcn8p	347	10	all	all	DT
cord-012418-6ralcn8p	347	11	mediate	mediate	VBP
cord-012418-6ralcn8p	347	12	K48-linked	K48-linked	NNP
cord-012418-6ralcn8p	347	13	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	347	14	and	and	CC
cord-012418-6ralcn8p	347	15	subsequent	subsequent	JJ
cord-012418-6ralcn8p	347	16	degradation	degradation	NN
cord-012418-6ralcn8p	347	17	of	of	IN
cord-012418-6ralcn8p	347	18	activated	activate	VBN
cord-012418-6ralcn8p	347	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	347	20	.	.	.
cord-012418-6ralcn8p	348	1	For	for	IN
cord-012418-6ralcn8p	348	2	example	example	NN
cord-012418-6ralcn8p	348	3	,	,	,
cord-012418-6ralcn8p	348	4	the	the	DT
cord-012418-6ralcn8p	348	5	peptidyl	peptidyl	JJ
cord-012418-6ralcn8p	348	6	-	-	HYPH
cord-012418-6ralcn8p	348	7	prolyl	prolyl	JJ
cord-012418-6ralcn8p	348	8	isomerase	isomerase	NN
cord-012418-6ralcn8p	348	9	Pin1	Pin1	NNP
cord-012418-6ralcn8p	348	10	specifically	specifically	RB
cord-012418-6ralcn8p	348	11	mediates	mediate	VBZ
cord-012418-6ralcn8p	348	12	degradation	degradation	NN
cord-012418-6ralcn8p	348	13	of	of	IN
cord-012418-6ralcn8p	348	14	the	the	DT
cord-012418-6ralcn8p	348	15	activated	activate	VBN
cord-012418-6ralcn8p	348	16	transcription	transcription	NN
cord-012418-6ralcn8p	348	17	factor	factor	NN
cord-012418-6ralcn8p	348	18	by	by	IN
cord-012418-6ralcn8p	348	19	recognition	recognition	NN
cord-012418-6ralcn8p	348	20	of	of	IN
cord-012418-6ralcn8p	348	21	a	a	DT
cord-012418-6ralcn8p	348	22	further	further	JJ
cord-012418-6ralcn8p	348	23	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	348	24	motif	motif	NN
cord-012418-6ralcn8p	348	25	(	(	-LRB-
cord-012418-6ralcn8p	348	26	S339phos	S339phos	NNP
cord-012418-6ralcn8p	348	27	-	-	HYPH
cord-012418-6ralcn8p	348	28	P340	P340	NNP
cord-012418-6ralcn8p	348	29	)	)	-RRB-
cord-012418-6ralcn8p	348	30	IRF3	IRF3	NNP
cord-012418-6ralcn8p	348	31	acquired	acquire	VBD
cord-012418-6ralcn8p	348	32	during	during	IN
cord-012418-6ralcn8p	348	33	stimulation	stimulation	NN
cord-012418-6ralcn8p	348	34	[	[	-LRB-
cord-012418-6ralcn8p	348	35	134	134	CD
cord-012418-6ralcn8p	348	36	]	]	-RRB-
cord-012418-6ralcn8p	348	37	.	.	.
cord-012418-6ralcn8p	349	1	Additionally	additionally	RB
cord-012418-6ralcn8p	349	2	,	,	,
cord-012418-6ralcn8p	349	3	viral	viral	JJ
cord-012418-6ralcn8p	349	4	infection	infection	NN
cord-012418-6ralcn8p	349	5	promotes	promote	VBZ
cord-012418-6ralcn8p	349	6	the	the	DT
cord-012418-6ralcn8p	349	7	nuclear	nuclear	JJ
cord-012418-6ralcn8p	349	8	localisation	localisation	NN
cord-012418-6ralcn8p	349	9	of	of	IN
cord-012418-6ralcn8p	349	10	the	the	DT
cord-012418-6ralcn8p	349	11	E3	E3	NNP
cord-012418-6ralcn8p	349	12	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	349	13	ligase	ligase	NN
cord-012418-6ralcn8p	349	14	TRIM26	TRIM26	NNP
cord-012418-6ralcn8p	349	15	,	,	,
cord-012418-6ralcn8p	349	16	allowing	allow	VBG
cord-012418-6ralcn8p	349	17	TRIM26	TRIM26	NNP
cord-012418-6ralcn8p	349	18	to	to	TO
cord-012418-6ralcn8p	349	19	bind	bind	VB
cord-012418-6ralcn8p	349	20	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	349	21	IRF3	IRF3	NNP
cord-012418-6ralcn8p	349	22	in	in	IN
cord-012418-6ralcn8p	349	23	the	the	DT
cord-012418-6ralcn8p	349	24	nucleus	nucleus	NN
cord-012418-6ralcn8p	349	25	and	and	CC
cord-012418-6ralcn8p	349	26	promote	promote	VB
cord-012418-6ralcn8p	349	27	its	-PRON-	PRP$
cord-012418-6ralcn8p	349	28	K48-linked	K48-linked	NNP
cord-012418-6ralcn8p	349	29	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	349	30	and	and	CC
cord-012418-6ralcn8p	349	31	degradation	degradation	NN
cord-012418-6ralcn8p	349	32	[	[	-LRB-
cord-012418-6ralcn8p	349	33	157	157	CD
cord-012418-6ralcn8p	349	34	]	]	-RRB-
cord-012418-6ralcn8p	349	35	.	.	.
cord-012418-6ralcn8p	350	1	Similarly	similarly	RB
cord-012418-6ralcn8p	350	2	,	,	,
cord-012418-6ralcn8p	350	3	production	production	NN
cord-012418-6ralcn8p	350	4	of	of	IN
cord-012418-6ralcn8p	350	5	RBCC	RBCC	NNP
cord-012418-6ralcn8p	350	6	protein	protein	NN
cord-012418-6ralcn8p	350	7	interacting	interact	VBG
cord-012418-6ralcn8p	350	8	with	with	IN
cord-012418-6ralcn8p	350	9	PKC1	PKC1	NNP
cord-012418-6ralcn8p	350	10	(	(	-LRB-
cord-012418-6ralcn8p	350	11	RBCK1	RBCK1	NNP
cord-012418-6ralcn8p	350	12	)	)	-RRB-
cord-012418-6ralcn8p	350	13	,	,	,
cord-012418-6ralcn8p	350	14	another	another	DT
cord-012418-6ralcn8p	350	15	E3	e3	NN
cord-012418-6ralcn8p	350	16	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	350	17	ligase	ligase	NN
cord-012418-6ralcn8p	350	18	,	,	,
cord-012418-6ralcn8p	350	19	is	be	VBZ
cord-012418-6ralcn8p	350	20	induced	induce	VBN
cord-012418-6ralcn8p	350	21	by	by	IN
cord-012418-6ralcn8p	350	22	viral	viral	JJ
cord-012418-6ralcn8p	350	23	stimulation	stimulation	NN
cord-012418-6ralcn8p	350	24	and	and	CC
cord-012418-6ralcn8p	350	25	targets	target	VBZ
cord-012418-6ralcn8p	350	26	IRF3	IRF3	NNP
cord-012418-6ralcn8p	350	27	for	for	IN
cord-012418-6ralcn8p	350	28	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	350	29	[	[	-LRB-
cord-012418-6ralcn8p	350	30	158	158	CD
cord-012418-6ralcn8p	350	31	]	]	-RRB-
cord-012418-6ralcn8p	350	32	.	.	.
cord-012418-6ralcn8p	351	1	Furthermore	furthermore	RB
cord-012418-6ralcn8p	351	2	,	,	,
cord-012418-6ralcn8p	351	3	caspase-8	caspase-8	NNP
cord-012418-6ralcn8p	351	4	(	(	-LRB-
cord-012418-6ralcn8p	351	5	CASP8	CASP8	NNP
cord-012418-6ralcn8p	351	6	)	)	-RRB-
cord-012418-6ralcn8p	351	7	is	be	VBZ
cord-012418-6ralcn8p	351	8	activated	activate	VBN
cord-012418-6ralcn8p	351	9	by	by	IN
cord-012418-6ralcn8p	351	10	cytosolic	cytosolic	JJ
cord-012418-6ralcn8p	351	11	RIG	rig	NN
cord-012418-6ralcn8p	351	12	-	-	HYPH
cord-012418-6ralcn8p	351	13	I	i	NN
cord-012418-6ralcn8p	351	14	-	-	HYPH
cord-012418-6ralcn8p	351	15	dependent	dependent	JJ
cord-012418-6ralcn8p	351	16	signalling	signalling	NN
cord-012418-6ralcn8p	351	17	and	and	CC
cord-012418-6ralcn8p	351	18	cleaves	cleave	VBZ
cord-012418-6ralcn8p	351	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	351	20	at	at	IN
cord-012418-6ralcn8p	351	21	a	a	DT
cord-012418-6ralcn8p	351	22	recognition	recognition	NN
cord-012418-6ralcn8p	351	23	motif	motif	NN
cord-012418-6ralcn8p	351	24	between	between	IN
cord-012418-6ralcn8p	351	25	DBD	DBD	NNP
cord-012418-6ralcn8p	351	26	and	and	CC
cord-012418-6ralcn8p	351	27	IAD	IAD	NNP
cord-012418-6ralcn8p	351	28	(	(	-LRB-
cord-012418-6ralcn8p	351	29	118	118	CD
cord-012418-6ralcn8p	351	30	SQPD	SQPD	NNS
cord-012418-6ralcn8p	351	31	121	121	CD
cord-012418-6ralcn8p	351	32	)	)	-RRB-
cord-012418-6ralcn8p	351	33	,	,	,
cord-012418-6ralcn8p	351	34	inducing	induce	VBG
cord-012418-6ralcn8p	351	35	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	351	36	and	and	CC
cord-012418-6ralcn8p	351	37	degradation	degradation	NN
cord-012418-6ralcn8p	351	38	of	of	IN
cord-012418-6ralcn8p	351	39	the	the	DT
cord-012418-6ralcn8p	351	40	fragments	fragment	NNS
cord-012418-6ralcn8p	351	41	[	[	-LRB-
cord-012418-6ralcn8p	351	42	159	159	CD
cord-012418-6ralcn8p	351	43	]	]	-RRB-
cord-012418-6ralcn8p	351	44	.	.	.
cord-012418-6ralcn8p	352	1	In	in	IN
cord-012418-6ralcn8p	352	2	parallel	parallel	NN
cord-012418-6ralcn8p	352	3	to	to	IN
cord-012418-6ralcn8p	352	4	the	the	DT
cord-012418-6ralcn8p	352	5	activation	activation	NN
cord-012418-6ralcn8p	352	6	of	of	IN
cord-012418-6ralcn8p	352	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	352	8	,	,	,
cord-012418-6ralcn8p	352	9	viral	viral	JJ
cord-012418-6ralcn8p	352	10	stimulation	stimulation	NN
cord-012418-6ralcn8p	352	11	also	also	RB
cord-012418-6ralcn8p	352	12	activates	activate	VBZ
cord-012418-6ralcn8p	352	13	inhibitors	inhibitor	NNS
cord-012418-6ralcn8p	352	14	of	of	IN
cord-012418-6ralcn8p	352	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	352	16	.	.	.
cord-012418-6ralcn8p	353	1	The	the	DT
cord-012418-6ralcn8p	353	2	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	353	3	regulator	regulator	NN
cord-012418-6ralcn8p	353	4	Krüppel	Krüppel	NNP
cord-012418-6ralcn8p	353	5	-	-	HYPH
cord-012418-6ralcn8p	353	6	like	like	JJ
cord-012418-6ralcn8p	353	7	factor	factor	NN
cord-012418-6ralcn8p	353	8	4	4	CD
cord-012418-6ralcn8p	353	9	(	(	-LRB-
cord-012418-6ralcn8p	353	10	KLF4	KLF4	NNP
cord-012418-6ralcn8p	353	11	)	)	-RRB-
cord-012418-6ralcn8p	353	12	,	,	,
cord-012418-6ralcn8p	353	13	which	which	WDT
cord-012418-6ralcn8p	353	14	is	be	VBZ
cord-012418-6ralcn8p	353	15	widely	widely	RB
cord-012418-6ralcn8p	353	16	expressed	express	VBN
cord-012418-6ralcn8p	353	17	in	in	IN
cord-012418-6ralcn8p	353	18	human	human	JJ
cord-012418-6ralcn8p	353	19	tissues	tissue	NNS
cord-012418-6ralcn8p	353	20	,	,	,
cord-012418-6ralcn8p	353	21	increasingly	increasingly	RB
cord-012418-6ralcn8p	353	22	localises	localise	VBZ
cord-012418-6ralcn8p	353	23	to	to	IN
cord-012418-6ralcn8p	353	24	the	the	DT
cord-012418-6ralcn8p	353	25	nucleus	nucleus	NN
cord-012418-6ralcn8p	353	26	after	after	IN
cord-012418-6ralcn8p	353	27	viral	viral	JJ
cord-012418-6ralcn8p	353	28	infection	infection	NN
cord-012418-6ralcn8p	353	29	where	where	WRB
cord-012418-6ralcn8p	353	30	it	-PRON-	PRP
cord-012418-6ralcn8p	353	31	binds	bind	VBZ
cord-012418-6ralcn8p	353	32	to	to	IN
cord-012418-6ralcn8p	353	33	the	the	DT
cord-012418-6ralcn8p	353	34	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	353	35	promoter	promoter	NN
cord-012418-6ralcn8p	353	36	region	region	NN
cord-012418-6ralcn8p	353	37	[	[	-LRB-
cord-012418-6ralcn8p	353	38	160	160	CD
cord-012418-6ralcn8p	353	39	]	]	-RRB-
cord-012418-6ralcn8p	353	40	.	.	.
cord-012418-6ralcn8p	354	1	This	this	DT
cord-012418-6ralcn8p	354	2	reduces	reduce	VBZ
cord-012418-6ralcn8p	354	3	recruitment	recruitment	NN
cord-012418-6ralcn8p	354	4	of	of	IN
cord-012418-6ralcn8p	354	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	354	6	and	and	CC
cord-012418-6ralcn8p	354	7	thus	thus	RB
cord-012418-6ralcn8p	354	8	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	354	9	induction	induction	NN
cord-012418-6ralcn8p	354	10	of	of	IN
cord-012418-6ralcn8p	354	11	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	354	12	expression	expression	NN
cord-012418-6ralcn8p	354	13	.	.	.
cord-012418-6ralcn8p	355	1	In	in	IN
cord-012418-6ralcn8p	355	2	immune	immune	JJ
cord-012418-6ralcn8p	355	3	cells	cell	NNS
cord-012418-6ralcn8p	355	4	,	,	,
cord-012418-6ralcn8p	355	5	the	the	DT
cord-012418-6ralcn8p	355	6	lysine	lysine	NN
cord-012418-6ralcn8p	355	7	acetyltransferase	acetyltransferase	NN
cord-012418-6ralcn8p	355	8	KAT8	KAT8	NNP
cord-012418-6ralcn8p	355	9	was	be	VBD
cord-012418-6ralcn8p	355	10	identified	identify	VBN
cord-012418-6ralcn8p	355	11	by	by	IN
cord-012418-6ralcn8p	355	12	an	an	DT
cord-012418-6ralcn8p	355	13	siRNA	siRNA	NNP
cord-012418-6ralcn8p	355	14	-	-	HYPH
cord-012418-6ralcn8p	355	15	screen	screen	NN
cord-012418-6ralcn8p	355	16	as	as	IN
cord-012418-6ralcn8p	355	17	a	a	DT
cord-012418-6ralcn8p	355	18	negative	negative	JJ
cord-012418-6ralcn8p	355	19	regulator	regulator	NN
cord-012418-6ralcn8p	355	20	of	of	IN
cord-012418-6ralcn8p	355	21	antiviral	antiviral	JJ
cord-012418-6ralcn8p	355	22	innate	innate	JJ
cord-012418-6ralcn8p	355	23	immunity	immunity	NN
cord-012418-6ralcn8p	355	24	[	[	-LRB-
cord-012418-6ralcn8p	355	25	161	161	CD
cord-012418-6ralcn8p	355	26	]	]	-RRB-
cord-012418-6ralcn8p	355	27	.	.	.
cord-012418-6ralcn8p	356	1	Viral	viral	JJ
cord-012418-6ralcn8p	356	2	infection	infection	NN
cord-012418-6ralcn8p	356	3	promotes	promote	VBZ
cord-012418-6ralcn8p	356	4	KAT8-mediated	kat8-mediated	JJ
cord-012418-6ralcn8p	356	5	acetylation	acetylation	NN
cord-012418-6ralcn8p	356	6	of	of	IN
cord-012418-6ralcn8p	356	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	356	8	at	at	IN
cord-012418-6ralcn8p	356	9	K359	K359	NNPS
cord-012418-6ralcn8p	356	10	,	,	,
cord-012418-6ralcn8p	356	11	independent	independent	JJ
cord-012418-6ralcn8p	356	12	of	of	IN
cord-012418-6ralcn8p	356	13	the	the	DT
cord-012418-6ralcn8p	356	14	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	356	15	and	and	CC
cord-012418-6ralcn8p	356	16	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	356	17	status	status	NN
cord-012418-6ralcn8p	356	18	of	of	IN
cord-012418-6ralcn8p	356	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	356	20	,	,	,
cord-012418-6ralcn8p	356	21	and	and	CC
cord-012418-6ralcn8p	356	22	this	this	DT
cord-012418-6ralcn8p	356	23	modification	modification	NN
cord-012418-6ralcn8p	356	24	interferes	interfere	VBZ
cord-012418-6ralcn8p	356	25	with	with	IN
cord-012418-6ralcn8p	356	26	binding	binding	NN
cord-012418-6ralcn8p	356	27	of	of	IN
cord-012418-6ralcn8p	356	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	356	29	to	to	IN
cord-012418-6ralcn8p	356	30	the	the	DT
cord-012418-6ralcn8p	356	31	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	356	32	enhancer	enhancer	NN
cord-012418-6ralcn8p	356	33	.	.	.
cord-012418-6ralcn8p	357	1	A	a	DT
cord-012418-6ralcn8p	357	2	potential	potential	JJ
cord-012418-6ralcn8p	357	3	effect	effect	NN
cord-012418-6ralcn8p	357	4	on	on	IN
cord-012418-6ralcn8p	357	5	assembly	assembly	NN
cord-012418-6ralcn8p	357	6	of	of	IN
cord-012418-6ralcn8p	357	7	the	the	DT
cord-012418-6ralcn8p	358	1	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	358	2	/	/	SYM
cord-012418-6ralcn8p	358	3	p300	p300	NNP
cord-012418-6ralcn8p	358	4	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	358	5	was	be	VBD
cord-012418-6ralcn8p	358	6	not	not	RB
cord-012418-6ralcn8p	358	7	characterised	characterise	VBN
cord-012418-6ralcn8p	358	8	,	,	,
cord-012418-6ralcn8p	358	9	however	however	RB
cord-012418-6ralcn8p	358	10	,	,	,
cord-012418-6ralcn8p	358	11	leaving	leave	VBG
cord-012418-6ralcn8p	358	12	the	the	DT
cord-012418-6ralcn8p	358	13	exact	exact	JJ
cord-012418-6ralcn8p	358	14	step	step	NN
cord-012418-6ralcn8p	358	15	of	of	IN
cord-012418-6ralcn8p	358	16	interference	interference	NN
cord-012418-6ralcn8p	358	17	to	to	TO
cord-012418-6ralcn8p	358	18	be	be	VB
cord-012418-6ralcn8p	358	19	determined	determine	VBN
cord-012418-6ralcn8p	358	20	.	.	.
cord-012418-6ralcn8p	359	1	A	a	DT
cord-012418-6ralcn8p	359	2	further	further	JJ
cord-012418-6ralcn8p	359	3	line	line	NN
cord-012418-6ralcn8p	359	4	of	of	IN
cord-012418-6ralcn8p	359	5	down	down	NN
cord-012418-6ralcn8p	359	6	-	-	HYPH
cord-012418-6ralcn8p	359	7	regulation	regulation	NN
cord-012418-6ralcn8p	359	8	is	be	VBZ
cord-012418-6ralcn8p	359	9	introduced	introduce	VBN
cord-012418-6ralcn8p	359	10	by	by	IN
cord-012418-6ralcn8p	359	11	the	the	DT
cord-012418-6ralcn8p	359	12	expression	expression	NN
cord-012418-6ralcn8p	359	13	of	of	IN
cord-012418-6ralcn8p	359	14	ISGs	isg	NNS
cord-012418-6ralcn8p	359	15	that	that	WDT
cord-012418-6ralcn8p	359	16	negatively	negatively	RB
cord-012418-6ralcn8p	359	17	modulate	modulate	VBP
cord-012418-6ralcn8p	359	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	359	19	activity	activity	NN
cord-012418-6ralcn8p	359	20	.	.	.
cord-012418-6ralcn8p	360	1	Considering	consider	VBG
cord-012418-6ralcn8p	360	2	the	the	DT
cord-012418-6ralcn8p	360	3	multitude	multitude	NN
cord-012418-6ralcn8p	360	4	of	of	IN
cord-012418-6ralcn8p	360	5	induced	induce	VBN
cord-012418-6ralcn8p	360	6	ISGs	ISGs	NNPS
cord-012418-6ralcn8p	360	7	[	[	-LRB-
cord-012418-6ralcn8p	360	8	162	162	CD
cord-012418-6ralcn8p	360	9	]	]	-RRB-
cord-012418-6ralcn8p	360	10	,	,	,
cord-012418-6ralcn8p	360	11	it	-PRON-	PRP
cord-012418-6ralcn8p	360	12	is	be	VBZ
cord-012418-6ralcn8p	360	13	not	not	RB
cord-012418-6ralcn8p	360	14	surprising	surprising	JJ
cord-012418-6ralcn8p	360	15	that	that	IN
cord-012418-6ralcn8p	360	16	they	-PRON-	PRP
cord-012418-6ralcn8p	360	17	target	target	VBP
cord-012418-6ralcn8p	360	18	various	various	JJ
cord-012418-6ralcn8p	360	19	levels	level	NNS
cord-012418-6ralcn8p	360	20	to	to	TO
cord-012418-6ralcn8p	360	21	terminate	terminate	VB
cord-012418-6ralcn8p	360	22	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	360	23	transcription	transcription	NN
cord-012418-6ralcn8p	360	24	.	.	.
cord-012418-6ralcn8p	361	1	Nuclear	nuclear	JJ
cord-012418-6ralcn8p	361	2	import	import	NN
cord-012418-6ralcn8p	361	3	is	be	VBZ
cord-012418-6ralcn8p	361	4	repressed	repress	VBN
cord-012418-6ralcn8p	361	5	by	by	IN
cord-012418-6ralcn8p	361	6	the	the	DT
cord-012418-6ralcn8p	361	7	increasing	increase	VBG
cord-012418-6ralcn8p	361	8	interaction	interaction	NN
cord-012418-6ralcn8p	361	9	of	of	IN
cord-012418-6ralcn8p	361	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	361	11	with	with	IN
cord-012418-6ralcn8p	361	12	the	the	DT
cord-012418-6ralcn8p	361	13	IFN	IFN	NNP
cord-012418-6ralcn8p	361	14	-	-	HYPH
cord-012418-6ralcn8p	361	15	inducible	inducible	JJ
cord-012418-6ralcn8p	361	16	DEAD	DEAD	NNP
cord-012418-6ralcn8p	361	17	-	-	HYPH
cord-012418-6ralcn8p	361	18	box	box	NN
cord-012418-6ralcn8p	361	19	RNA	RNA	NNP
cord-012418-6ralcn8p	361	20	helicase	helicase	NN
cord-012418-6ralcn8p	361	21	DDX56	DDX56	NNP
cord-012418-6ralcn8p	361	22	,	,	,
cord-012418-6ralcn8p	361	23	as	as	IN
cord-012418-6ralcn8p	361	24	this	this	DT
cord-012418-6ralcn8p	361	25	interaction	interaction	NN
cord-012418-6ralcn8p	361	26	competes	compete	VBZ
cord-012418-6ralcn8p	361	27	with	with	IN
cord-012418-6ralcn8p	361	28	the	the	DT
cord-012418-6ralcn8p	361	29	association	association	NN
cord-012418-6ralcn8p	361	30	of	of	IN
cord-012418-6ralcn8p	361	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	361	32	and	and	CC
cord-012418-6ralcn8p	361	33	IPO5	IPO5	NNP
cord-012418-6ralcn8p	361	34	[	[	-LRB-
cord-012418-6ralcn8p	361	35	163	163	CD
cord-012418-6ralcn8p	361	36	]	]	-RRB-
cord-012418-6ralcn8p	361	37	.	.	.
cord-012418-6ralcn8p	362	1	The	the	DT
cord-012418-6ralcn8p	362	2	IRF3-DNA	IRF3-DNA	NNP
cord-012418-6ralcn8p	362	3	interaction	interaction	NN
cord-012418-6ralcn8p	362	4	is	be	VBZ
cord-012418-6ralcn8p	362	5	inhibited	inhibit	VBN
cord-012418-6ralcn8p	362	6	by	by	IN
cord-012418-6ralcn8p	362	7	interaction	interaction	NN
cord-012418-6ralcn8p	362	8	of	of	IN
cord-012418-6ralcn8p	362	9	newly	newly	RB
cord-012418-6ralcn8p	362	10	synthesized	synthesize	VBN
cord-012418-6ralcn8p	362	11	cell	cell	NN
cord-012418-6ralcn8p	362	12	growth	growth	NN
cord-012418-6ralcn8p	362	13	-	-	HYPH
cord-012418-6ralcn8p	362	14	regulating	regulate	VBG
cord-012418-6ralcn8p	362	15	nucleolar	nucleolar	JJ
cord-012418-6ralcn8p	362	16	protein	protein	NN
cord-012418-6ralcn8p	362	17	LYAR	LYAR	NNP
cord-012418-6ralcn8p	362	18	(	(	-LRB-
cord-012418-6ralcn8p	362	19	Ly1	ly1	JJ
cord-012418-6ralcn8p	362	20	antibody	antibody	NN
cord-012418-6ralcn8p	362	21	-	-	HYPH
cord-012418-6ralcn8p	362	22	reactive	reactive	JJ
cord-012418-6ralcn8p	362	23	)	)	-RRB-
cord-012418-6ralcn8p	362	24	,	,	,
cord-012418-6ralcn8p	362	25	which	which	WDT
cord-012418-6ralcn8p	362	26	is	be	VBZ
cord-012418-6ralcn8p	362	27	usually	usually	RB
cord-012418-6ralcn8p	362	28	low	low	JJ
cord-012418-6ralcn8p	362	29	expressed	express	VBN
cord-012418-6ralcn8p	362	30	in	in	IN
cord-012418-6ralcn8p	362	31	most	most	JJS
cord-012418-6ralcn8p	362	32	cell	cell	NN
cord-012418-6ralcn8p	362	33	tissues	tissue	NNS
cord-012418-6ralcn8p	362	34	but	but	CC
cord-012418-6ralcn8p	362	35	induced	induce	VBN
cord-012418-6ralcn8p	362	36	by	by	IN
cord-012418-6ralcn8p	362	37	the	the	DT
cord-012418-6ralcn8p	362	38	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	362	39	response	response	NN
cord-012418-6ralcn8p	362	40	[	[	-LRB-
cord-012418-6ralcn8p	362	41	164	164	CD
cord-012418-6ralcn8p	362	42	]	]	-RRB-
cord-012418-6ralcn8p	362	43	.	.	.
cord-012418-6ralcn8p	363	1	LYAR	LYAR	NNP
cord-012418-6ralcn8p	363	2	interacts	interact	VBZ
cord-012418-6ralcn8p	363	3	specifically	specifically	RB
cord-012418-6ralcn8p	363	4	with	with	IN
cord-012418-6ralcn8p	363	5	the	the	DT
cord-012418-6ralcn8p	363	6	N	n	CD
cord-012418-6ralcn8p	363	7	-	-	HYPH
cord-012418-6ralcn8p	363	8	terminal	terminal	NN
cord-012418-6ralcn8p	363	9	domain	domain	NN
cord-012418-6ralcn8p	363	10	of	of	IN
cord-012418-6ralcn8p	363	11	activated	activate	VBN
cord-012418-6ralcn8p	363	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	363	13	and	and	CC
cord-012418-6ralcn8p	363	14	in	in	IN
cord-012418-6ralcn8p	363	15	this	this	DT
cord-012418-6ralcn8p	363	16	way	way	NN
cord-012418-6ralcn8p	363	17	interferes	interfere	VBZ
cord-012418-6ralcn8p	363	18	with	with	IN
cord-012418-6ralcn8p	363	19	the	the	DT
cord-012418-6ralcn8p	363	20	DNA	dna	NN
cord-012418-6ralcn8p	363	21	-	-	HYPH
cord-012418-6ralcn8p	363	22	binding	bind	VBG
cord-012418-6ralcn8p	363	23	capacity	capacity	NN
cord-012418-6ralcn8p	363	24	of	of	IN
cord-012418-6ralcn8p	363	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	363	26	in	in	IN
cord-012418-6ralcn8p	363	27	the	the	DT
cord-012418-6ralcn8p	363	28	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	363	29	/	/	SYM
cord-012418-6ralcn8p	363	30	p300	p300	NNP
cord-012418-6ralcn8p	363	31	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	363	32	.	.	.
cord-012418-6ralcn8p	364	1	Additionally	additionally	RB
cord-012418-6ralcn8p	364	2	,	,	,
cord-012418-6ralcn8p	364	3	a	a	DT
cord-012418-6ralcn8p	364	4	long	long	JJ
cord-012418-6ralcn8p	364	5	non	non	JJ
cord-012418-6ralcn8p	364	6	-	-	JJ
cord-012418-6ralcn8p	364	7	coding	coding	JJ
cord-012418-6ralcn8p	364	8	RNA	RNA	NNP
cord-012418-6ralcn8p	364	9	directly	directly	RB
cord-012418-6ralcn8p	364	10	targets	target	VBZ
cord-012418-6ralcn8p	364	11	the	the	DT
cord-012418-6ralcn8p	364	12	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	364	13	promoter	promoter	NN
cord-012418-6ralcn8p	364	14	region	region	NN
cord-012418-6ralcn8p	364	15	and	and	CC
cord-012418-6ralcn8p	364	16	interferes	interfere	VBZ
cord-012418-6ralcn8p	364	17	with	with	IN
cord-012418-6ralcn8p	364	18	transcription	transcription	NN
cord-012418-6ralcn8p	364	19	factor	factor	NN
cord-012418-6ralcn8p	364	20	binding	bind	VBG
cord-012418-6ralcn8p	364	21	in	in	IN
cord-012418-6ralcn8p	364	22	a	a	DT
cord-012418-6ralcn8p	364	23	unique	unique	JJ
cord-012418-6ralcn8p	364	24	way	way	NN
cord-012418-6ralcn8p	364	25	[	[	-LRB-
cord-012418-6ralcn8p	364	26	165	165	CD
cord-012418-6ralcn8p	364	27	]	]	-RRB-
cord-012418-6ralcn8p	364	28	:	:	:
cord-012418-6ralcn8p	365	1	After	after	IN
cord-012418-6ralcn8p	365	2	RNA	RNA	NNP
cord-012418-6ralcn8p	365	3	deep	deep	JJ
cord-012418-6ralcn8p	365	4	sequencing	sequencing	NN
cord-012418-6ralcn8p	365	5	revealed	reveal	VBD
cord-012418-6ralcn8p	365	6	enhanced	enhanced	JJ
cord-012418-6ralcn8p	365	7	transcription	transcription	NN
cord-012418-6ralcn8p	365	8	of	of	IN
cord-012418-6ralcn8p	365	9	the	the	DT
cord-012418-6ralcn8p	365	10	long	long	JJ
cord-012418-6ralcn8p	365	11	non	non	JJ
cord-012418-6ralcn8p	365	12	-	-	JJ
cord-012418-6ralcn8p	365	13	coding	coding	JJ
cord-012418-6ralcn8p	365	14	RNA	RNA	NNP
cord-012418-6ralcn8p	365	15	lnc	lnc	NNP
cord-012418-6ralcn8p	365	16	-	-	HYPH
cord-012418-6ralcn8p	365	17	MxA	MxA	NNP
cord-012418-6ralcn8p	365	18	from	from	IN
cord-012418-6ralcn8p	365	19	the	the	DT
cord-012418-6ralcn8p	365	20	MxA	mxa	NN
cord-012418-6ralcn8p	365	21	locus	locus	NN
cord-012418-6ralcn8p	365	22	after	after	IN
cord-012418-6ralcn8p	365	23	viral	viral	JJ
cord-012418-6ralcn8p	365	24	infection	infection	NN
cord-012418-6ralcn8p	365	25	,	,	,
cord-012418-6ralcn8p	365	26	Li	Li	NNP
cord-012418-6ralcn8p	365	27	and	and	CC
cord-012418-6ralcn8p	365	28	colleagues	colleague	NNS
cord-012418-6ralcn8p	365	29	recently	recently	RB
cord-012418-6ralcn8p	365	30	reported	report	VBD
cord-012418-6ralcn8p	365	31	its	-PRON-	PRP$
cord-012418-6ralcn8p	365	32	mechanism	mechanism	NN
cord-012418-6ralcn8p	365	33	of	of	IN
cord-012418-6ralcn8p	365	34	action	action	NN
cord-012418-6ralcn8p	365	35	.	.	.
cord-012418-6ralcn8p	366	1	Applying	apply	VBG
cord-012418-6ralcn8p	366	2	a	a	DT
cord-012418-6ralcn8p	366	3	chromatin	chromatin	NN
cord-012418-6ralcn8p	366	4	isolation	isolation	NN
cord-012418-6ralcn8p	366	5	by	by	IN
cord-012418-6ralcn8p	366	6	RNA	RNA	NNP
cord-012418-6ralcn8p	366	7	purification	purification	NN
cord-012418-6ralcn8p	366	8	assay	assay	NN
cord-012418-6ralcn8p	366	9	and	and	CC
cord-012418-6ralcn8p	366	10	in	in	IN
cord-012418-6ralcn8p	366	11	vitro	vitro	FW
cord-012418-6ralcn8p	366	12	pulldown	pulldown	NN
cord-012418-6ralcn8p	366	13	of	of	IN
cord-012418-6ralcn8p	366	14	an	an	DT
cord-012418-6ralcn8p	366	15	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	366	16	promoter	promoter	NN
cord-012418-6ralcn8p	366	17	dsDNA	dsdna	RB
cord-012418-6ralcn8p	366	18	fragment	fragment	NN
cord-012418-6ralcn8p	366	19	with	with	IN
cord-012418-6ralcn8p	366	20	biotin	biotin	NN
cord-012418-6ralcn8p	366	21	-	-	HYPH
cord-012418-6ralcn8p	366	22	labelled	label	VBN
cord-012418-6ralcn8p	366	23	lnc	lnc	NNP
cord-012418-6ralcn8p	366	24	-	-	HYPH
cord-012418-6ralcn8p	366	25	MxA	MxA	NNP
cord-012418-6ralcn8p	366	26	,	,	,
cord-012418-6ralcn8p	366	27	they	-PRON-	PRP
cord-012418-6ralcn8p	366	28	demonstrated	demonstrate	VBD
cord-012418-6ralcn8p	366	29	that	that	IN
cord-012418-6ralcn8p	366	30	lnc	lnc	NNP
cord-012418-6ralcn8p	366	31	-	-	HYPH
cord-012418-6ralcn8p	366	32	MxA	MxA	NNP
cord-012418-6ralcn8p	366	33	forms	form	VBZ
cord-012418-6ralcn8p	366	34	an	an	DT
cord-012418-6ralcn8p	366	35	RNA	RNA	NNP
cord-012418-6ralcn8p	366	36	-	-	HYPH
cord-012418-6ralcn8p	366	37	DNA	dna	NN
cord-012418-6ralcn8p	366	38	triplex	triplex	NN
cord-012418-6ralcn8p	366	39	with	with	IN
cord-012418-6ralcn8p	366	40	the	the	DT
cord-012418-6ralcn8p	366	41	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	366	42	promoter	promoter	NN
cord-012418-6ralcn8p	366	43	region	region	NN
cord-012418-6ralcn8p	366	44	.	.	.
cord-012418-6ralcn8p	367	1	This	this	DT
cord-012418-6ralcn8p	367	2	changes	change	VBZ
cord-012418-6ralcn8p	367	3	the	the	DT
cord-012418-6ralcn8p	367	4	structure	structure	NN
cord-012418-6ralcn8p	367	5	of	of	IN
cord-012418-6ralcn8p	367	6	the	the	DT
cord-012418-6ralcn8p	367	7	chromatin	chromatin	NN
cord-012418-6ralcn8p	367	8	and	and	CC
cord-012418-6ralcn8p	367	9	interferes	interfere	VBZ
cord-012418-6ralcn8p	367	10	with	with	IN
cord-012418-6ralcn8p	367	11	binding	binding	NN
cord-012418-6ralcn8p	367	12	of	of	IN
cord-012418-6ralcn8p	367	13	the	the	DT
cord-012418-6ralcn8p	367	14	transcription	transcription	NN
cord-012418-6ralcn8p	367	15	factors	factor	NNS
cord-012418-6ralcn8p	367	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	367	17	and	and	CC
cord-012418-6ralcn8p	367	18	NF	NF	NNP
cord-012418-6ralcn8p	367	19	-	-	HYPH
cord-012418-6ralcn8p	367	20	κB	κB	NNP
cord-012418-6ralcn8p	367	21	to	to	IN
cord-012418-6ralcn8p	367	22	their	-PRON-	PRP$
cord-012418-6ralcn8p	367	23	respective	respective	JJ
cord-012418-6ralcn8p	367	24	target	target	NN
cord-012418-6ralcn8p	367	25	sequence	sequence	NN
cord-012418-6ralcn8p	367	26	[	[	-LRB-
cord-012418-6ralcn8p	367	27	165	165	CD
cord-012418-6ralcn8p	367	28	]	]	-RRB-
cord-012418-6ralcn8p	367	29	.	.	.
cord-012418-6ralcn8p	368	1	Finally	finally	RB
cord-012418-6ralcn8p	368	2	,	,	,
cord-012418-6ralcn8p	368	3	the	the	DT
cord-012418-6ralcn8p	368	4	delayed	delay	VBN
cord-012418-6ralcn8p	368	5	generation	generation	NN
cord-012418-6ralcn8p	368	6	of	of	IN
cord-012418-6ralcn8p	368	7	PRDI	PRDI	NNP
cord-012418-6ralcn8p	368	8	-	-	HYPH
cord-012418-6ralcn8p	368	9	binding	bind	VBG
cord-012418-6ralcn8p	368	10	factor	factor	NN
cord-012418-6ralcn8p	368	11	1	1	CD
cord-012418-6ralcn8p	368	12	(	(	-LRB-
cord-012418-6ralcn8p	368	13	PRDI	PRDI	NNP
cord-012418-6ralcn8p	368	14	-	-	HYPH
cord-012418-6ralcn8p	368	15	BF1	BF1	NNP
cord-012418-6ralcn8p	368	16	,	,	,
cord-012418-6ralcn8p	368	17	or	or	CC
cord-012418-6ralcn8p	368	18	PR	PR	NNP
cord-012418-6ralcn8p	368	19	/	/	SYM
cord-012418-6ralcn8p	368	20	SET	set	NN
cord-012418-6ralcn8p	368	21	domain	domain	NN
cord-012418-6ralcn8p	368	22	1	1	CD
cord-012418-6ralcn8p	368	23	)	)	-RRB-
cord-012418-6ralcn8p	368	24	mediates	mediate	VBZ
cord-012418-6ralcn8p	368	25	recruitment	recruitment	NN
cord-012418-6ralcn8p	368	26	of	of	IN
cord-012418-6ralcn8p	368	27	the	the	DT
cord-012418-6ralcn8p	368	28	histone	histone	NN
cord-012418-6ralcn8p	368	29	H3	H3	NNP
cord-012418-6ralcn8p	368	30	lysine	lysine	NN
cord-012418-6ralcn8p	369	1	methyltransferase	methyltransferase	NNP
cord-012418-6ralcn8p	369	2	G9a	G9a	NNP
cord-012418-6ralcn8p	369	3	for	for	IN
cord-012418-6ralcn8p	369	4	epigenetic	epigenetic	JJ
cord-012418-6ralcn8p	369	5	silencing	silencing	NN
cord-012418-6ralcn8p	369	6	of	of	IN
cord-012418-6ralcn8p	369	7	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	369	8	expression	expression	NN
cord-012418-6ralcn8p	369	9	[	[	-LRB-
cord-012418-6ralcn8p	369	10	166	166	CD
cord-012418-6ralcn8p	369	11	,	,	,
cord-012418-6ralcn8p	369	12	167	167	CD
cord-012418-6ralcn8p	369	13	]	]	-RRB-
cord-012418-6ralcn8p	369	14	.	.	.
cord-012418-6ralcn8p	370	1	The	the	DT
cord-012418-6ralcn8p	370	2	following	follow	VBG
cord-012418-6ralcn8p	370	3	host	host	NN
cord-012418-6ralcn8p	370	4	factors	factor	NNS
cord-012418-6ralcn8p	370	5	were	be	VBD
cord-012418-6ralcn8p	370	6	additionally	additionally	RB
cord-012418-6ralcn8p	370	7	reported	report	VBN
cord-012418-6ralcn8p	370	8	as	as	IN
cord-012418-6ralcn8p	370	9	negative	negative	JJ
cord-012418-6ralcn8p	370	10	modulators	modulator	NNS
cord-012418-6ralcn8p	370	11	of	of	IN
cord-012418-6ralcn8p	370	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	370	13	activity	activity	NN
cord-012418-6ralcn8p	370	14	,	,	,
cord-012418-6ralcn8p	370	15	but	but	CC
cord-012418-6ralcn8p	370	16	it	-PRON-	PRP
cord-012418-6ralcn8p	370	17	remains	remain	VBZ
cord-012418-6ralcn8p	370	18	to	to	TO
cord-012418-6ralcn8p	370	19	be	be	VB
cord-012418-6ralcn8p	370	20	seen	see	VBN
cord-012418-6ralcn8p	370	21	if	if	IN
cord-012418-6ralcn8p	370	22	they	-PRON-	PRP
cord-012418-6ralcn8p	370	23	constantly	constantly	RB
cord-012418-6ralcn8p	370	24	inhibit	inhibit	VBP
cord-012418-6ralcn8p	370	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	370	26	or	or	CC
cord-012418-6ralcn8p	370	27	how	how	WRB
cord-012418-6ralcn8p	370	28	they	-PRON-	PRP
cord-012418-6ralcn8p	370	29	are	be	VBP
cord-012418-6ralcn8p	370	30	regulated	regulate	VBN
cord-012418-6ralcn8p	370	31	.	.	.
cord-012418-6ralcn8p	371	1	For	for	IN
cord-012418-6ralcn8p	371	2	instance	instance	NN
cord-012418-6ralcn8p	371	3	,	,	,
cord-012418-6ralcn8p	371	4	calmodulin	calmodulin	NN
cord-012418-6ralcn8p	371	5	-	-	HYPH
cord-012418-6ralcn8p	371	6	like	like	JJ
cord-012418-6ralcn8p	371	7	protein	protein	NN
cord-012418-6ralcn8p	371	8	6	6	CD
cord-012418-6ralcn8p	371	9	(	(	-LRB-
cord-012418-6ralcn8p	371	10	CALML6	CALML6	NNP
cord-012418-6ralcn8p	371	11	or	or	CC
cord-012418-6ralcn8p	371	12	CAGLP	CAGLP	NNP
cord-012418-6ralcn8p	371	13	)	)	-RRB-
cord-012418-6ralcn8p	371	14	was	be	VBD
cord-012418-6ralcn8p	371	15	identified	identify	VBN
cord-012418-6ralcn8p	371	16	to	to	TO
cord-012418-6ralcn8p	371	17	negatively	negatively	RB
cord-012418-6ralcn8p	371	18	modulate	modulate	VB
cord-012418-6ralcn8p	371	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	371	20	and	and	CC
cord-012418-6ralcn8p	371	21	independently	independently	RB
cord-012418-6ralcn8p	371	22	of	of	IN
cord-012418-6ralcn8p	371	23	the	the	DT
cord-012418-6ralcn8p	371	24	protein	protein	NN
cord-012418-6ralcn8p	371	25	's	's	POS
cord-012418-6ralcn8p	371	26	ability	ability	NN
cord-012418-6ralcn8p	371	27	to	to	TO
cord-012418-6ralcn8p	371	28	bind	bind	VB
cord-012418-6ralcn8p	371	29	calcium	calcium	NN
cord-012418-6ralcn8p	371	30	ions	ion	NNS
cord-012418-6ralcn8p	371	31	[	[	-LRB-
cord-012418-6ralcn8p	371	32	168	168	CD
cord-012418-6ralcn8p	371	33	]	]	-RRB-
cord-012418-6ralcn8p	371	34	.	.	.
cord-012418-6ralcn8p	372	1	CALML6	CALML6	NNP
cord-012418-6ralcn8p	372	2	interacts	interact	VBZ
cord-012418-6ralcn8p	372	3	with	with	IN
cord-012418-6ralcn8p	372	4	the	the	DT
cord-012418-6ralcn8p	372	5	C	c	NN
cord-012418-6ralcn8p	372	6	-	-	HYPH
cord-012418-6ralcn8p	372	7	terminal	terminal	NN
cord-012418-6ralcn8p	372	8	AIE	aie	NN
cord-012418-6ralcn8p	372	9	of	of	IN
cord-012418-6ralcn8p	372	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	372	11	,	,	,
cord-012418-6ralcn8p	372	12	and	and	CC
cord-012418-6ralcn8p	372	13	this	this	DT
cord-012418-6ralcn8p	372	14	interaction	interaction	NN
cord-012418-6ralcn8p	372	15	is	be	VBZ
cord-012418-6ralcn8p	372	16	strengthened	strengthen	VBN
cord-012418-6ralcn8p	372	17	when	when	WRB
cord-012418-6ralcn8p	372	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	372	19	is	be	VBZ
cord-012418-6ralcn8p	372	20	phosphorylated	phosphorylate	VBN
cord-012418-6ralcn8p	372	21	.	.	.
cord-012418-6ralcn8p	373	1	After	after	IN
cord-012418-6ralcn8p	373	2	virus	virus	NN
cord-012418-6ralcn8p	373	3	infection	infection	NN
cord-012418-6ralcn8p	373	4	,	,	,
cord-012418-6ralcn8p	373	5	CALML6	CALML6	NNP
cord-012418-6ralcn8p	373	6	thereby	thereby	RB
cord-012418-6ralcn8p	373	7	impairs	impair	VBZ
cord-012418-6ralcn8p	373	8	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	373	9	and	and	CC
cord-012418-6ralcn8p	373	10	nuclear	nuclear	JJ
cord-012418-6ralcn8p	373	11	import	import	NN
cord-012418-6ralcn8p	373	12	of	of	IN
cord-012418-6ralcn8p	373	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	373	14	.	.	.
cord-012418-6ralcn8p	374	1	The	the	DT
cord-012418-6ralcn8p	374	2	contribution	contribution	NN
cord-012418-6ralcn8p	374	3	of	of	IN
cord-012418-6ralcn8p	374	4	cellular	cellular	JJ
cord-012418-6ralcn8p	374	5	FLIP	FLIP	NNP
cord-012418-6ralcn8p	374	6	long	long	JJ
cord-012418-6ralcn8p	374	7	isoform	isoform	NN
cord-012418-6ralcn8p	374	8	protein	protein	NN
cord-012418-6ralcn8p	374	9	(	(	-LRB-
cord-012418-6ralcn8p	374	10	cFLIP	cFLIP	NNP
cord-012418-6ralcn8p	374	11	L	L	NNP
cord-012418-6ralcn8p	374	12	)	)	-RRB-
cord-012418-6ralcn8p	374	13	to	to	IN
cord-012418-6ralcn8p	374	14	regulation	regulation	NN
cord-012418-6ralcn8p	374	15	of	of	IN
cord-012418-6ralcn8p	374	16	the	the	DT
cord-012418-6ralcn8p	374	17	type	type	NN
cord-012418-6ralcn8p	374	18	I	-PRON-	PRP
cord-012418-6ralcn8p	374	19	IFN	IFN	NNP
cord-012418-6ralcn8p	374	20	response	response	NN
cord-012418-6ralcn8p	374	21	in	in	IN
cord-012418-6ralcn8p	374	22	several	several	JJ
cord-012418-6ralcn8p	374	23	primary	primary	JJ
cord-012418-6ralcn8p	374	24	cancers	cancer	NNS
cord-012418-6ralcn8p	374	25	was	be	VBD
cord-012418-6ralcn8p	374	26	reported	report	VBN
cord-012418-6ralcn8p	374	27	by	by	IN
cord-012418-6ralcn8p	374	28	several	several	JJ
cord-012418-6ralcn8p	374	29	groups	group	NNS
cord-012418-6ralcn8p	374	30	with	with	IN
cord-012418-6ralcn8p	374	31	contradicting	contradict	VBG
cord-012418-6ralcn8p	374	32	outcomes	outcome	NNS
cord-012418-6ralcn8p	374	33	,	,	,
cord-012418-6ralcn8p	374	34	so	so	CC
cord-012418-6ralcn8p	374	35	Gates	Gates	NNP
cord-012418-6ralcn8p	374	36	and	and	CC
cord-012418-6ralcn8p	374	37	colleagues	colleague	NNS
cord-012418-6ralcn8p	374	38	studied	study	VBD
cord-012418-6ralcn8p	374	39	the	the	DT
cord-012418-6ralcn8p	374	40	underlying	underlying	JJ
cord-012418-6ralcn8p	374	41	mechanism	mechanism	NN
cord-012418-6ralcn8p	374	42	of	of	IN
cord-012418-6ralcn8p	374	43	action	action	NN
cord-012418-6ralcn8p	374	44	and	and	CC
cord-012418-6ralcn8p	374	45	concluded	conclude	VBD
cord-012418-6ralcn8p	374	46	on	on	IN
cord-012418-6ralcn8p	374	47	an	an	DT
cord-012418-6ralcn8p	374	48	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	374	49	function	function	NN
cord-012418-6ralcn8p	374	50	[	[	-LRB-
cord-012418-6ralcn8p	374	51	169	169	CD
cord-012418-6ralcn8p	374	52	]	]	-RRB-
cord-012418-6ralcn8p	374	53	.	.	.
cord-012418-6ralcn8p	375	1	When	when	WRB
cord-012418-6ralcn8p	375	2	ectopically	ectopically	RB
cord-012418-6ralcn8p	375	3	expressed	express	VBN
cord-012418-6ralcn8p	375	4	in	in	IN
cord-012418-6ralcn8p	375	5	HEK293	HEK293	NNP
cord-012418-6ralcn8p	375	6	T	T	NNP
cord-012418-6ralcn8p	375	7	cells	cell	NNS
cord-012418-6ralcn8p	375	8	,	,	,
cord-012418-6ralcn8p	375	9	cFLIP	cFLIP	NNP
cord-012418-6ralcn8p	375	10	L	L	NNP
cord-012418-6ralcn8p	375	11	interacts	interact	VBZ
cord-012418-6ralcn8p	375	12	with	with	IN
cord-012418-6ralcn8p	375	13	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	375	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	375	15	within	within	IN
cord-012418-6ralcn8p	375	16	the	the	DT
cord-012418-6ralcn8p	375	17	nucleus	nucleus	NN
cord-012418-6ralcn8p	375	18	and	and	CC
cord-012418-6ralcn8p	375	19	hinders	hinder	VBZ
cord-012418-6ralcn8p	375	20	interaction	interaction	NN
cord-012418-6ralcn8p	375	21	with	with	IN
cord-012418-6ralcn8p	375	22	CBP	CBP	NNP
cord-012418-6ralcn8p	375	23	and	and	CC
cord-012418-6ralcn8p	375	24	thus	thus	RB
cord-012418-6ralcn8p	375	25	with	with	IN
cord-012418-6ralcn8p	375	26	the	the	DT
cord-012418-6ralcn8p	375	27	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	375	28	enhancer	enhancer	NN
cord-012418-6ralcn8p	375	29	.	.	.
cord-012418-6ralcn8p	376	1	cFLIP	cFLIP	NNP
cord-012418-6ralcn8p	377	1	L	L	NNP
cord-012418-6ralcn8p	377	2	was	be	VBD
cord-012418-6ralcn8p	377	3	then	then	RB
cord-012418-6ralcn8p	377	4	confirmed	confirm	VBN
cord-012418-6ralcn8p	377	5	to	to	TO
cord-012418-6ralcn8p	377	6	be	be	VB
cord-012418-6ralcn8p	377	7	highly	highly	RB
cord-012418-6ralcn8p	377	8	expressed	express	VBN
cord-012418-6ralcn8p	377	9	in	in	IN
cord-012418-6ralcn8p	377	10	several	several	JJ
cord-012418-6ralcn8p	377	11	human	human	JJ
cord-012418-6ralcn8p	377	12	cancer	cancer	NN
cord-012418-6ralcn8p	377	13	cell	cell	NN
cord-012418-6ralcn8p	377	14	lines	line	NNS
cord-012418-6ralcn8p	377	15	and	and	CC
cord-012418-6ralcn8p	377	16	to	to	TO
cord-012418-6ralcn8p	377	17	interact	interact	VB
cord-012418-6ralcn8p	377	18	with	with	IN
cord-012418-6ralcn8p	377	19	endogenous	endogenous	JJ
cord-012418-6ralcn8p	377	20	IRF3	IRF3	NNP
cord-012418-6ralcn8p	377	21	,	,	,
cord-012418-6ralcn8p	377	22	mediating	mediate	VBG
cord-012418-6ralcn8p	377	23	reduction	reduction	NN
cord-012418-6ralcn8p	377	24	of	of	IN
cord-012418-6ralcn8p	377	25	ISG	ISG	NNP
cord-012418-6ralcn8p	377	26	expression	expression	NN
cord-012418-6ralcn8p	377	27	.	.	.
cord-012418-6ralcn8p	378	1	As	as	IN
cord-012418-6ralcn8p	378	2	opposed	oppose	VBN
cord-012418-6ralcn8p	378	3	to	to	IN
cord-012418-6ralcn8p	378	4	the	the	DT
cord-012418-6ralcn8p	378	5	major	major	JJ
cord-012418-6ralcn8p	378	6	isoform	isoform	NN
cord-012418-6ralcn8p	378	7	(	(	-LRB-
cord-012418-6ralcn8p	378	8	variant	variant	NN
cord-012418-6ralcn8p	378	9	1	1	CD
cord-012418-6ralcn8p	378	10	)	)	-RRB-
cord-012418-6ralcn8p	378	11	of	of	IN
cord-012418-6ralcn8p	378	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	378	13	that	that	WDT
cord-012418-6ralcn8p	378	14	drives	drive	VBZ
cord-012418-6ralcn8p	378	15	the	the	DT
cord-012418-6ralcn8p	378	16	type	type	NN
cord-012418-6ralcn8p	378	17	I	-PRON-	PRP
cord-012418-6ralcn8p	378	18	IFN	IFN	NNP
cord-012418-6ralcn8p	378	19	response	response	NN
cord-012418-6ralcn8p	378	20	as	as	IN
cord-012418-6ralcn8p	378	21	discussed	discuss	VBN
cord-012418-6ralcn8p	378	22	so	so	RB
cord-012418-6ralcn8p	378	23	far	far	RB
cord-012418-6ralcn8p	378	24	,	,	,
cord-012418-6ralcn8p	378	25	three	three	CD
cord-012418-6ralcn8p	378	26	of	of	IN
cord-012418-6ralcn8p	378	27	the	the	DT
cord-012418-6ralcn8p	378	28	five	five	CD
cord-012418-6ralcn8p	378	29	described	describe	VBN
cord-012418-6ralcn8p	378	30	splice	splice	NN
cord-012418-6ralcn8p	378	31	-	-	HYPH
cord-012418-6ralcn8p	378	32	variants	variant	NNS
cord-012418-6ralcn8p	378	33	of	of	IN
cord-012418-6ralcn8p	378	34	human	human	JJ
cord-012418-6ralcn8p	378	35	IRF3	IRF3	NNP
cord-012418-6ralcn8p	378	36	negatively	negatively	RB
cord-012418-6ralcn8p	378	37	modulate	modulate	VBP
cord-012418-6ralcn8p	378	38	the	the	DT
cord-012418-6ralcn8p	378	39	biological	biological	JJ
cord-012418-6ralcn8p	378	40	activity	activity	NN
cord-012418-6ralcn8p	378	41	of	of	IN
cord-012418-6ralcn8p	378	42	IRF3	IRF3	NNP
cord-012418-6ralcn8p	378	43	,	,	,
cord-012418-6ralcn8p	378	44	though	though	IN
cord-012418-6ralcn8p	378	45	their	-PRON-	PRP$
cord-012418-6ralcn8p	378	46	regulation	regulation	NN
cord-012418-6ralcn8p	378	47	remains	remain	VBZ
cord-012418-6ralcn8p	378	48	to	to	TO
cord-012418-6ralcn8p	378	49	be	be	VB
cord-012418-6ralcn8p	378	50	determined	determine	VBN
cord-012418-6ralcn8p	378	51	.	.	.
cord-012418-6ralcn8p	379	1	Translation	translation	NN
cord-012418-6ralcn8p	379	2	of	of	IN
cord-012418-6ralcn8p	379	3	variant	variant	JJ
cord-012418-6ralcn8p	379	4	2	2	CD
cord-012418-6ralcn8p	379	5	(	(	-LRB-
cord-012418-6ralcn8p	379	6	IRF3-CL	IRF3-CL	NNP
cord-012418-6ralcn8p	379	7	)	)	-RRB-
cord-012418-6ralcn8p	379	8	yields	yield	VBZ
cord-012418-6ralcn8p	379	9	a	a	DT
cord-012418-6ralcn8p	379	10	slightly	slightly	RB
cord-012418-6ralcn8p	379	11	longer	long	JJR
cord-012418-6ralcn8p	379	12	protein	protein	NN
cord-012418-6ralcn8p	379	13	(	(	-LRB-
cord-012418-6ralcn8p	379	14	452	452	CD
cord-012418-6ralcn8p	379	15	AA	AA	NNP
cord-012418-6ralcn8p	379	16	)	)	-RRB-
cord-012418-6ralcn8p	379	17	with	with	IN
cord-012418-6ralcn8p	379	18	a	a	DT
cord-012418-6ralcn8p	379	19	unique	unique	JJ
cord-012418-6ralcn8p	379	20	sequence	sequence	NN
cord-012418-6ralcn8p	379	21	of	of	IN
cord-012418-6ralcn8p	379	22	125	125	CD
cord-012418-6ralcn8p	379	23	AA	aa	NN
cord-012418-6ralcn8p	379	24	in	in	IN
cord-012418-6ralcn8p	379	25	the	the	DT
cord-012418-6ralcn8p	379	26	C	c	NN
cord-012418-6ralcn8p	379	27	-	-	HYPH
cord-012418-6ralcn8p	379	28	terminus	terminus	NN
cord-012418-6ralcn8p	379	29	that	that	WDT
cord-012418-6ralcn8p	379	30	lacks	lack	VBZ
cord-012418-6ralcn8p	379	31	a	a	DT
cord-012418-6ralcn8p	379	32	part	part	NN
cord-012418-6ralcn8p	379	33	of	of	IN
cord-012418-6ralcn8p	379	34	the	the	DT
cord-012418-6ralcn8p	379	35	IAD	IAD	NNP
cord-012418-6ralcn8p	379	36	including	include	VBG
cord-012418-6ralcn8p	379	37	the	the	DT
cord-012418-6ralcn8p	379	38	AIE	aie	NN
cord-012418-6ralcn8p	379	39	of	of	IN
cord-012418-6ralcn8p	379	40	IRF3	IRF3	NNP
cord-012418-6ralcn8p	379	41	[	[	-LRB-
cord-012418-6ralcn8p	379	42	170	170	CD
cord-012418-6ralcn8p	379	43	]	]	-RRB-
cord-012418-6ralcn8p	379	44	.	.	.
cord-012418-6ralcn8p	380	1	IRF3-CL	irf3-cl	POS
cord-012418-6ralcn8p	380	2	constitutively	constitutively	RB
cord-012418-6ralcn8p	380	3	forms	form	VBZ
cord-012418-6ralcn8p	380	4	homodimers	homodimer	NNS
cord-012418-6ralcn8p	380	5	that	that	WDT
cord-012418-6ralcn8p	380	6	localize	localize	VBP
cord-012418-6ralcn8p	380	7	to	to	IN
cord-012418-6ralcn8p	380	8	the	the	DT
cord-012418-6ralcn8p	380	9	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	380	10	.	.	.
cord-012418-6ralcn8p	381	1	After	after	IN
cord-012418-6ralcn8p	381	2	viral	viral	JJ
cord-012418-6ralcn8p	381	3	stimulation	stimulation	NN
cord-012418-6ralcn8p	381	4	,	,	,
cord-012418-6ralcn8p	381	5	IKK	IKK	NNP
cord-012418-6ralcn8p	381	6	-	-	HYPH
cord-012418-6ralcn8p	381	7	mediated	mediate	VBN
cord-012418-6ralcn8p	381	8	activation	activation	NN
cord-012418-6ralcn8p	381	9	induces	induce	VBZ
cord-012418-6ralcn8p	381	10	association	association	NN
cord-012418-6ralcn8p	381	11	of	of	IN
cord-012418-6ralcn8p	381	12	IRF3-CL	IRF3-CL	NNP
cord-012418-6ralcn8p	381	13	with	with	IN
cord-012418-6ralcn8p	381	14	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	381	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	381	16	,	,	,
cord-012418-6ralcn8p	381	17	but	but	CC
cord-012418-6ralcn8p	381	18	the	the	DT
cord-012418-6ralcn8p	381	19	heterodimers	heterodimer	NNS
cord-012418-6ralcn8p	381	20	are	be	VBP
cord-012418-6ralcn8p	381	21	retained	retain	VBN
cord-012418-6ralcn8p	381	22	in	in	IN
cord-012418-6ralcn8p	381	23	the	the	DT
cord-012418-6ralcn8p	381	24	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	381	25	and	and	CC
cord-012418-6ralcn8p	381	26	consequently	consequently	RB
cord-012418-6ralcn8p	381	27	,	,	,
cord-012418-6ralcn8p	381	28	the	the	DT
cord-012418-6ralcn8p	381	29	association	association	NN
cord-012418-6ralcn8p	381	30	with	with	IN
cord-012418-6ralcn8p	381	31	this	this	DT
cord-012418-6ralcn8p	381	32	isoform	isoform	NN
cord-012418-6ralcn8p	381	33	keeps	keep	VBZ
cord-012418-6ralcn8p	381	34	IRF3	IRF3	NNP
cord-012418-6ralcn8p	381	35	from	from	IN
cord-012418-6ralcn8p	381	36	the	the	DT
cord-012418-6ralcn8p	381	37	induction	induction	NN
cord-012418-6ralcn8p	381	38	of	of	IN
cord-012418-6ralcn8p	381	39	IFNB1	ifnb1	DT
cord-012418-6ralcn8p	381	40	expression	expression	NN
cord-012418-6ralcn8p	381	41	.	.	.
cord-012418-6ralcn8p	382	1	In	in	IN
cord-012418-6ralcn8p	382	2	contrast	contrast	NN
cord-012418-6ralcn8p	382	3	,	,	,
cord-012418-6ralcn8p	382	4	variant	variant	NN
cord-012418-6ralcn8p	382	5	3	3	CD
cord-012418-6ralcn8p	382	6	(	(	-LRB-
cord-012418-6ralcn8p	382	7	IRF3a	irf3a	NN
cord-012418-6ralcn8p	382	8	)	)	-RRB-
cord-012418-6ralcn8p	382	9	lacks	lack	VBZ
cord-012418-6ralcn8p	382	10	the	the	DT
cord-012418-6ralcn8p	382	11	N	n	CD
cord-012418-6ralcn8p	382	12	-	-	HYPH
cord-012418-6ralcn8p	382	13	terminal	terminal	JJ
cord-012418-6ralcn8p	382	14	part	part	NN
cord-012418-6ralcn8p	382	15	of	of	IN
cord-012418-6ralcn8p	382	16	the	the	DT
cord-012418-6ralcn8p	382	17	functional	functional	JJ
cord-012418-6ralcn8p	382	18	DBD	DBD	NNP
cord-012418-6ralcn8p	382	19	of	of	IN
cord-012418-6ralcn8p	382	20	IRF3	IRF3	NNP
cord-012418-6ralcn8p	382	21	and	and	CC
cord-012418-6ralcn8p	382	22	is	be	VBZ
cord-012418-6ralcn8p	382	23	consequently	consequently	RB
cord-012418-6ralcn8p	382	24	unable	unable	JJ
cord-012418-6ralcn8p	382	25	to	to	TO
cord-012418-6ralcn8p	382	26	bind	bind	VB
cord-012418-6ralcn8p	382	27	to	to	IN
cord-012418-6ralcn8p	382	28	classical	classical	JJ
cord-012418-6ralcn8p	382	29	IRF	IRF	NNP
cord-012418-6ralcn8p	382	30	-	-	HYPH
cord-012418-6ralcn8p	382	31	Es	Es	NNP
cord-012418-6ralcn8p	382	32	[	[	-LRB-
cord-012418-6ralcn8p	382	33	171	171	CD
cord-012418-6ralcn8p	382	34	,	,	,
cord-012418-6ralcn8p	382	35	172	172	CD
cord-012418-6ralcn8p	382	36	]	]	-RRB-
cord-012418-6ralcn8p	382	37	.	.	.
cord-012418-6ralcn8p	383	1	This	this	DT
cord-012418-6ralcn8p	383	2	isoform	isoform	NN
cord-012418-6ralcn8p	383	3	also	also	RB
cord-012418-6ralcn8p	383	4	heterodimerises	heterodimerise	VBZ
cord-012418-6ralcn8p	383	5	with	with	IN
cord-012418-6ralcn8p	383	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	383	7	variant	variant	NN
cord-012418-6ralcn8p	383	8	1	1	CD
cord-012418-6ralcn8p	383	9	after	after	IN
cord-012418-6ralcn8p	383	10	stimulation	stimulation	NN
cord-012418-6ralcn8p	383	11	,	,	,
cord-012418-6ralcn8p	383	12	but	but	CC
cord-012418-6ralcn8p	383	13	in	in	IN
cord-012418-6ralcn8p	383	14	line	line	NN
cord-012418-6ralcn8p	383	15	with	with	IN
cord-012418-6ralcn8p	383	16	the	the	DT
cord-012418-6ralcn8p	383	17	absent	absent	JJ
cord-012418-6ralcn8p	383	18	DBD	DBD	NNP
cord-012418-6ralcn8p	383	19	,	,	,
cord-012418-6ralcn8p	383	20	its	-PRON-	PRP$
cord-012418-6ralcn8p	383	21	presence	presence	NN
cord-012418-6ralcn8p	383	22	selectively	selectively	RB
cord-012418-6ralcn8p	383	23	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	383	24	virus	virus	NN
cord-012418-6ralcn8p	383	25	-	-	HYPH
cord-012418-6ralcn8p	383	26	induced	induce	VBN
cord-012418-6ralcn8p	383	27	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	383	28	transcription	transcription	NN
cord-012418-6ralcn8p	383	29	.	.	.
cord-012418-6ralcn8p	384	1	Interestingly	interestingly	RB
cord-012418-6ralcn8p	384	2	,	,	,
cord-012418-6ralcn8p	384	3	after	after	IN
cord-012418-6ralcn8p	384	4	virus	virus	NN
cord-012418-6ralcn8p	384	5	stimulation	stimulation	NN
cord-012418-6ralcn8p	384	6	,	,	,
cord-012418-6ralcn8p	384	7	IRF3a	IRF3a	NNP
cord-012418-6ralcn8p	384	8	is	be	VBZ
cord-012418-6ralcn8p	384	9	degraded	degrade	VBN
cord-012418-6ralcn8p	384	10	slower	slow	JJR
cord-012418-6ralcn8p	384	11	than	than	IN
cord-012418-6ralcn8p	384	12	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	384	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	384	14	and	and	CC
cord-012418-6ralcn8p	385	1	so	so	RB
cord-012418-6ralcn8p	385	2	the	the	DT
cord-012418-6ralcn8p	385	3	ratio	ratio	NN
cord-012418-6ralcn8p	385	4	of	of	IN
cord-012418-6ralcn8p	385	5	negative	negative	JJ
cord-012418-6ralcn8p	385	6	versus	versus	IN
cord-012418-6ralcn8p	385	7	positive	positive	JJ
cord-012418-6ralcn8p	385	8	modulator	modulator	NN
cord-012418-6ralcn8p	385	9	increases	increase	NNS
cord-012418-6ralcn8p	385	10	with	with	IN
cord-012418-6ralcn8p	385	11	ongoing	ongoing	JJ
cord-012418-6ralcn8p	385	12	infection	infection	NN
cord-012418-6ralcn8p	385	13	,	,	,
cord-012418-6ralcn8p	385	14	potentially	potentially	RB
cord-012418-6ralcn8p	385	15	contributing	contribute	VBG
cord-012418-6ralcn8p	385	16	to	to	IN
cord-012418-6ralcn8p	385	17	a	a	DT
cord-012418-6ralcn8p	385	18	downregulation	downregulation	NN
cord-012418-6ralcn8p	385	19	of	of	IN
cord-012418-6ralcn8p	385	20	the	the	DT
cord-012418-6ralcn8p	385	21	type	type	NN
cord-012418-6ralcn8p	385	22	I	-PRON-	PRP
cord-012418-6ralcn8p	385	23	IFN	IFN	NNP
cord-012418-6ralcn8p	385	24	response	response	NN
cord-012418-6ralcn8p	385	25	[	[	-LRB-
cord-012418-6ralcn8p	385	26	171	171	CD
cord-012418-6ralcn8p	385	27	]	]	-RRB-
cord-012418-6ralcn8p	385	28	.	.	.
cord-012418-6ralcn8p	386	1	The	the	DT
cord-012418-6ralcn8p	386	2	fourth	fourth	JJ
cord-012418-6ralcn8p	386	3	variant	variant	NN
cord-012418-6ralcn8p	386	4	,	,	,
cord-012418-6ralcn8p	386	5	IRF3e	IRF3e	NNPS
cord-012418-6ralcn8p	386	6	or	or	CC
cord-012418-6ralcn8p	386	7	IRF3-nirs	IRF3-nirs	NNP
cord-012418-6ralcn8p	386	8	,	,	,
cord-012418-6ralcn8p	386	9	was	be	VBD
cord-012418-6ralcn8p	386	10	discovered	discover	VBN
cord-012418-6ralcn8p	386	11	when	when	WRB
cord-012418-6ralcn8p	386	12	Marozin	Marozin	NNP
cord-012418-6ralcn8p	386	13	and	and	CC
cord-012418-6ralcn8p	386	14	colleagues	colleague	NNS
cord-012418-6ralcn8p	386	15	searched	search	VBD
cord-012418-6ralcn8p	386	16	for	for	IN
cord-012418-6ralcn8p	386	17	the	the	DT
cord-012418-6ralcn8p	386	18	reason	reason	NN
cord-012418-6ralcn8p	386	19	of	of	IN
cord-012418-6ralcn8p	386	20	the	the	DT
cord-012418-6ralcn8p	386	21	defect	defect	NN
cord-012418-6ralcn8p	386	22	in	in	IN
cord-012418-6ralcn8p	386	23	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	386	24	expression	expression	NN
cord-012418-6ralcn8p	386	25	in	in	IN
cord-012418-6ralcn8p	386	26	hepatocellular	hepatocellular	JJ
cord-012418-6ralcn8p	386	27	carcinoma	carcinoma	NN
cord-012418-6ralcn8p	386	28	(	(	-LRB-
cord-012418-6ralcn8p	386	29	HCC	HCC	NNP
cord-012418-6ralcn8p	386	30	)	)	-RRB-
cord-012418-6ralcn8p	386	31	cells	cell	NNS
cord-012418-6ralcn8p	386	32	and	and	CC
cord-012418-6ralcn8p	386	33	discovered	discover	VBD
cord-012418-6ralcn8p	386	34	that	that	IN
cord-012418-6ralcn8p	386	35	a	a	DT
cord-012418-6ralcn8p	386	36	truncated	truncated	JJ
cord-012418-6ralcn8p	386	37	variant	variant	NN
cord-012418-6ralcn8p	386	38	of	of	IN
cord-012418-6ralcn8p	386	39	IRF3	IRF3	NNP
cord-012418-6ralcn8p	386	40	was	be	VBD
cord-012418-6ralcn8p	386	41	constitutively	constitutively	RB
cord-012418-6ralcn8p	386	42	expressed	express	VBN
cord-012418-6ralcn8p	386	43	in	in	IN
cord-012418-6ralcn8p	386	44	primary	primary	JJ
cord-012418-6ralcn8p	386	45	cells	cell	NNS
cord-012418-6ralcn8p	386	46	of	of	IN
cord-012418-6ralcn8p	386	47	HCC	HCC	NNP
cord-012418-6ralcn8p	386	48	or	or	CC
cord-012418-6ralcn8p	386	49	HCC	HCC	NNP
cord-012418-6ralcn8p	386	50	cell	cell	NN
cord-012418-6ralcn8p	386	51	lines	line	NNS
cord-012418-6ralcn8p	386	52	but	but	CC
cord-012418-6ralcn8p	386	53	not	not	RB
cord-012418-6ralcn8p	386	54	in	in	IN
cord-012418-6ralcn8p	386	55	primary	primary	JJ
cord-012418-6ralcn8p	386	56	hepatocytes	hepatocyte	NNS
cord-012418-6ralcn8p	386	57	[	[	-LRB-
cord-012418-6ralcn8p	386	58	173	173	CD
cord-012418-6ralcn8p	386	59	]	]	-RRB-
cord-012418-6ralcn8p	386	60	.	.	.
cord-012418-6ralcn8p	387	1	IRF3-nirs	IRF3-nirs	NNP
cord-012418-6ralcn8p	387	2	is	be	VBZ
cord-012418-6ralcn8p	387	3	produced	produce	VBN
cord-012418-6ralcn8p	387	4	when	when	WRB
cord-012418-6ralcn8p	387	5	an	an	DT
cord-012418-6ralcn8p	387	6	in	in	IN
cord-012418-6ralcn8p	387	7	-	-	HYPH
cord-012418-6ralcn8p	387	8	frame	frame	NN
cord-012418-6ralcn8p	387	9	exon	exon	NN
cord-012418-6ralcn8p	387	10	is	be	VBZ
cord-012418-6ralcn8p	387	11	aberrantly	aberrantly	RB
cord-012418-6ralcn8p	387	12	skipped	skip	VBN
cord-012418-6ralcn8p	387	13	during	during	IN
cord-012418-6ralcn8p	387	14	splicing	splicing	NN
cord-012418-6ralcn8p	387	15	,	,	,
cord-012418-6ralcn8p	387	16	leading	lead	VBG
cord-012418-6ralcn8p	387	17	to	to	IN
cord-012418-6ralcn8p	387	18	the	the	DT
cord-012418-6ralcn8p	387	19	generation	generation	NN
cord-012418-6ralcn8p	387	20	of	of	IN
cord-012418-6ralcn8p	387	21	a	a	DT
cord-012418-6ralcn8p	387	22	protein	protein	NN
cord-012418-6ralcn8p	387	23	lacking	lack	VBG
cord-012418-6ralcn8p	387	24	127	127	CD
cord-012418-6ralcn8p	387	25	AA	aa	NN
cord-012418-6ralcn8p	387	26	within	within	IN
cord-012418-6ralcn8p	387	27	the	the	DT
cord-012418-6ralcn8p	387	28	β	β	NN
cord-012418-6ralcn8p	387	29	-	-	HYPH
cord-012418-6ralcn8p	387	30	sandwich	sandwich	NN
cord-012418-6ralcn8p	387	31	core	core	NN
cord-012418-6ralcn8p	387	32	of	of	IN
cord-012418-6ralcn8p	387	33	the	the	DT
cord-012418-6ralcn8p	387	34	IAD	IAD	NNP
cord-012418-6ralcn8p	387	35	.	.	.
cord-012418-6ralcn8p	388	1	In	in	IN
cord-012418-6ralcn8p	388	2	line	line	NN
cord-012418-6ralcn8p	388	3	with	with	IN
cord-012418-6ralcn8p	388	4	this	this	DT
cord-012418-6ralcn8p	388	5	,	,	,
cord-012418-6ralcn8p	388	6	this	this	DT
cord-012418-6ralcn8p	388	7	isoform	isoform	NN
cord-012418-6ralcn8p	388	8	is	be	VBZ
cord-012418-6ralcn8p	388	9	constitutively	constitutively	RB
cord-012418-6ralcn8p	388	10	active	active	JJ
cord-012418-6ralcn8p	388	11	and	and	CC
cord-012418-6ralcn8p	388	12	maintains	maintain	VBZ
cord-012418-6ralcn8p	388	13	the	the	DT
cord-012418-6ralcn8p	388	14	DNA	dna	NN
cord-012418-6ralcn8p	388	15	-	-	HYPH
cord-012418-6ralcn8p	388	16	binding	bind	VBG
cord-012418-6ralcn8p	388	17	ability	ability	NN
cord-012418-6ralcn8p	388	18	.	.	.
cord-012418-6ralcn8p	389	1	However	however	RB
cord-012418-6ralcn8p	389	2	,	,	,
cord-012418-6ralcn8p	389	3	due	due	IN
cord-012418-6ralcn8p	389	4	to	to	IN
cord-012418-6ralcn8p	389	5	the	the	DT
cord-012418-6ralcn8p	389	6	compromised	compromise	VBN
cord-012418-6ralcn8p	389	7	IAD	IAD	NNP
cord-012418-6ralcn8p	389	8	,	,	,
cord-012418-6ralcn8p	389	9	IRF3-nirs	IRF3-nirs	NNP
cord-012418-6ralcn8p	389	10	seems	seem	VBZ
cord-012418-6ralcn8p	389	11	unable	unable	JJ
cord-012418-6ralcn8p	389	12	to	to	TO
cord-012418-6ralcn8p	389	13	exercise	exercise	VB
cord-012418-6ralcn8p	389	14	trans	trans	NNP
cord-012418-6ralcn8p	389	15	-	-	JJ
cord-012418-6ralcn8p	389	16	activation	activation	JJ
cord-012418-6ralcn8p	389	17	activity	activity	NN
cord-012418-6ralcn8p	389	18	and	and	CC
cord-012418-6ralcn8p	389	19	instead	instead	RB
cord-012418-6ralcn8p	389	20	competes	compete	VBZ
cord-012418-6ralcn8p	389	21	with	with	IN
cord-012418-6ralcn8p	389	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	389	23	for	for	IN
cord-012418-6ralcn8p	389	24	the	the	DT
cord-012418-6ralcn8p	389	25	limited	limited	JJ
cord-012418-6ralcn8p	389	26	IRF	IRF	NNP
cord-012418-6ralcn8p	389	27	binding	bind	VBG
cord-012418-6ralcn8p	389	28	sites	site	NNS
cord-012418-6ralcn8p	389	29	in	in	IN
cord-012418-6ralcn8p	389	30	the	the	DT
cord-012418-6ralcn8p	389	31	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	389	32	enhancer	enhancer	NN
cord-012418-6ralcn8p	389	33	sequence	sequence	NN
cord-012418-6ralcn8p	389	34	[	[	-LRB-
cord-012418-6ralcn8p	389	35	173	173	CD
cord-012418-6ralcn8p	389	36	]	]	-RRB-
cord-012418-6ralcn8p	389	37	.	.	.
cord-012418-6ralcn8p	390	1	Surprisingly	surprisingly	RB
cord-012418-6ralcn8p	390	2	,	,	,
cord-012418-6ralcn8p	390	3	given	give	VBN
cord-012418-6ralcn8p	390	4	that	that	DT
cord-012418-6ralcn8p	390	5	association	association	NN
cord-012418-6ralcn8p	390	6	with	with	IN
cord-012418-6ralcn8p	390	7	the	the	DT
cord-012418-6ralcn8p	390	8	coactivator	coactivator	NN
cord-012418-6ralcn8p	390	9	is	be	VBZ
cord-012418-6ralcn8p	390	10	normally	normally	RB
cord-012418-6ralcn8p	390	11	essential	essential	JJ
cord-012418-6ralcn8p	390	12	for	for	IN
cord-012418-6ralcn8p	390	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	390	14	to	to	TO
cord-012418-6ralcn8p	390	15	bind	bind	VB
cord-012418-6ralcn8p	390	16	to	to	IN
cord-012418-6ralcn8p	390	17	DNA	dna	NN
cord-012418-6ralcn8p	390	18	motifs	motif	NNS
cord-012418-6ralcn8p	390	19	,	,	,
cord-012418-6ralcn8p	390	20	this	this	DT
cord-012418-6ralcn8p	390	21	implies	imply	VBZ
cord-012418-6ralcn8p	390	22	that	that	IN
cord-012418-6ralcn8p	390	23	the	the	DT
cord-012418-6ralcn8p	390	24	interaction	interaction	NN
cord-012418-6ralcn8p	390	25	surface	surface	NN
cord-012418-6ralcn8p	390	26	for	for	IN
cord-012418-6ralcn8p	390	27	CBP	CBP	NNP
cord-012418-6ralcn8p	390	28	/	/	SYM
cord-012418-6ralcn8p	390	29	p300	p300	NNP
cord-012418-6ralcn8p	390	30	remains	remain	VBZ
cord-012418-6ralcn8p	390	31	intact	intact	JJ
cord-012418-6ralcn8p	390	32	despite	despite	IN
cord-012418-6ralcn8p	390	33	the	the	DT
cord-012418-6ralcn8p	390	34	missing	miss	VBG
cord-012418-6ralcn8p	390	35	adjacent	adjacent	JJ
cord-012418-6ralcn8p	390	36	structural	structural	JJ
cord-012418-6ralcn8p	390	37	module	module	NN
cord-012418-6ralcn8p	390	38	.	.	.
cord-012418-6ralcn8p	391	1	In	in	IN
cord-012418-6ralcn8p	391	2	addition	addition	NN
cord-012418-6ralcn8p	391	3	to	to	IN
cord-012418-6ralcn8p	391	4	the	the	DT
cord-012418-6ralcn8p	391	5	human	human	JJ
cord-012418-6ralcn8p	391	6	isoforms	isoform	NNS
cord-012418-6ralcn8p	391	7	,	,	,
cord-012418-6ralcn8p	391	8	one	one	CD
cord-012418-6ralcn8p	391	9	variant	variant	NN
cord-012418-6ralcn8p	391	10	of	of	IN
cord-012418-6ralcn8p	391	11	murine	murine	JJ
cord-012418-6ralcn8p	391	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	391	13	,	,	,
cord-012418-6ralcn8p	391	14	mIRF-3a	mIRF-3a	NNP
cord-012418-6ralcn8p	391	15	,	,	,
cord-012418-6ralcn8p	391	16	was	be	VBD
cord-012418-6ralcn8p	391	17	reported	report	VBN
cord-012418-6ralcn8p	391	18	as	as	IN
cord-012418-6ralcn8p	391	19	a	a	DT
cord-012418-6ralcn8p	391	20	ubiquitously	ubiquitously	RB
cord-012418-6ralcn8p	391	21	expressed	express	VBN
cord-012418-6ralcn8p	391	22	negative	negative	JJ
cord-012418-6ralcn8p	391	23	modulator	modulator	NN
cord-012418-6ralcn8p	391	24	of	of	IN
cord-012418-6ralcn8p	391	25	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	391	26	induction	induction	VBP
cord-012418-6ralcn8p	391	27	in	in	IN
cord-012418-6ralcn8p	391	28	mice	mouse	NNS
cord-012418-6ralcn8p	391	29	[	[	-LRB-
cord-012418-6ralcn8p	391	30	174	174	CD
cord-012418-6ralcn8p	391	31	]	]	-RRB-
cord-012418-6ralcn8p	391	32	.	.	.
cord-012418-6ralcn8p	392	1	During	during	IN
cord-012418-6ralcn8p	392	2	the	the	DT
cord-012418-6ralcn8p	392	3	generation	generation	NN
cord-012418-6ralcn8p	392	4	of	of	IN
cord-012418-6ralcn8p	392	5	mIRF-3a	mIRF-3a	NNP
cord-012418-6ralcn8p	392	6	,	,	,
cord-012418-6ralcn8p	392	7	an	an	DT
cord-012418-6ralcn8p	392	8	alternative	alternative	JJ
cord-012418-6ralcn8p	392	9	donor	donor	NN
cord-012418-6ralcn8p	392	10	splice	splice	NN
cord-012418-6ralcn8p	392	11	site	site	NN
cord-012418-6ralcn8p	392	12	in	in	IN
cord-012418-6ralcn8p	392	13	exon	exon	NN
cord-012418-6ralcn8p	392	14	6	6	CD
cord-012418-6ralcn8p	392	15	is	be	VBZ
cord-012418-6ralcn8p	392	16	used	use	VBN
cord-012418-6ralcn8p	392	17	and	and	CC
cord-012418-6ralcn8p	392	18	leads	lead	VBZ
cord-012418-6ralcn8p	392	19	to	to	IN
cord-012418-6ralcn8p	392	20	a	a	DT
cord-012418-6ralcn8p	392	21	frameshift	frameshift	NN
cord-012418-6ralcn8p	392	22	with	with	IN
cord-012418-6ralcn8p	392	23	a	a	DT
cord-012418-6ralcn8p	392	24	premature	premature	JJ
cord-012418-6ralcn8p	392	25	termination	termination	NN
cord-012418-6ralcn8p	392	26	codon	codon	NN
cord-012418-6ralcn8p	392	27	,	,	,
cord-012418-6ralcn8p	392	28	yielding	yield	VBG
cord-012418-6ralcn8p	392	29	a	a	DT
cord-012418-6ralcn8p	392	30	shorter	short	JJR
cord-012418-6ralcn8p	392	31	variant	variant	NN
cord-012418-6ralcn8p	392	32	(	(	-LRB-
cord-012418-6ralcn8p	392	33	296	296	CD
cord-012418-6ralcn8p	392	34	AA	AA	NNP
cord-012418-6ralcn8p	392	35	)	)	-RRB-
cord-012418-6ralcn8p	392	36	which	which	WDT
cord-012418-6ralcn8p	392	37	differs	differ	VBZ
cord-012418-6ralcn8p	392	38	in	in	IN
cord-012418-6ralcn8p	392	39	the	the	DT
cord-012418-6ralcn8p	392	40	C	C	NNP
cord-012418-6ralcn8p	392	41	-	-	HYPH
cord-012418-6ralcn8p	392	42	terminal	terminal	NN
cord-012418-6ralcn8p	392	43	region	region	NN
cord-012418-6ralcn8p	392	44	as	as	IN
cord-012418-6ralcn8p	392	45	compared	compare	VBN
cord-012418-6ralcn8p	392	46	to	to	IN
cord-012418-6ralcn8p	392	47	the	the	DT
cord-012418-6ralcn8p	392	48	major	major	JJ
cord-012418-6ralcn8p	392	49	murine	murine	JJ
cord-012418-6ralcn8p	392	50	variant	variant	NN
cord-012418-6ralcn8p	392	51	(	(	-LRB-
cord-012418-6ralcn8p	392	52	419	419	CD
cord-012418-6ralcn8p	392	53	AA	AA	NNP
cord-012418-6ralcn8p	392	54	)	)	-RRB-
cord-012418-6ralcn8p	392	55	.	.	.
cord-012418-6ralcn8p	393	1	mIRF-3a	mIRF-3a	NFP
cord-012418-6ralcn8p	393	2	freely	freely	RB
cord-012418-6ralcn8p	393	3	localises	localise	VBZ
cord-012418-6ralcn8p	393	4	to	to	IN
cord-012418-6ralcn8p	393	5	the	the	DT
cord-012418-6ralcn8p	393	6	nucleus	nucleus	NN
cord-012418-6ralcn8p	393	7	,	,	,
cord-012418-6ralcn8p	393	8	binds	bind	VBZ
cord-012418-6ralcn8p	393	9	to	to	IN
cord-012418-6ralcn8p	393	10	IRF	IRF	NNP
cord-012418-6ralcn8p	393	11	recognition	recognition	NN
cord-012418-6ralcn8p	393	12	sites	site	NNS
cord-012418-6ralcn8p	393	13	and	and	CC
cord-012418-6ralcn8p	393	14	represses	repress	VBZ
cord-012418-6ralcn8p	393	15	promoter	promoter	NN
cord-012418-6ralcn8p	393	16	activation	activation	NN
cord-012418-6ralcn8p	393	17	.	.	.
cord-012418-6ralcn8p	394	1	Not	not	RB
cord-012418-6ralcn8p	394	2	long	long	RB
cord-012418-6ralcn8p	394	3	after	after	IN
cord-012418-6ralcn8p	394	4	the	the	DT
cord-012418-6ralcn8p	394	5	initial	initial	JJ
cord-012418-6ralcn8p	394	6	steps	step	NNS
cord-012418-6ralcn8p	394	7	in	in	IN
cord-012418-6ralcn8p	394	8	the	the	DT
cord-012418-6ralcn8p	394	9	characterisation	characterisation	NN
cord-012418-6ralcn8p	394	10	of	of	IN
cord-012418-6ralcn8p	394	11	the	the	DT
cord-012418-6ralcn8p	394	12	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	394	13	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	394	14	were	be	VBD
cord-012418-6ralcn8p	394	15	made	make	VBN
cord-012418-6ralcn8p	394	16	,	,	,
cord-012418-6ralcn8p	394	17	also	also	RB
cord-012418-6ralcn8p	394	18	the	the	DT
cord-012418-6ralcn8p	394	19	first	first	JJ
cord-012418-6ralcn8p	394	20	viral	viral	JJ
cord-012418-6ralcn8p	394	21	proteins	protein	NNS
cord-012418-6ralcn8p	394	22	targeting	target	VBG
cord-012418-6ralcn8p	394	23	its	-PRON-	PRP$
cord-012418-6ralcn8p	394	24	assembly	assembly	NN
cord-012418-6ralcn8p	394	25	were	be	VBD
cord-012418-6ralcn8p	394	26	noticed	notice	VBN
cord-012418-6ralcn8p	394	27	[	[	-LRB-
cord-012418-6ralcn8p	394	28	175	175	CD
cord-012418-6ralcn8p	394	29	,	,	,
cord-012418-6ralcn8p	394	30	176	176	CD
cord-012418-6ralcn8p	394	31	]	]	-RRB-
cord-012418-6ralcn8p	394	32	.	.	.
cord-012418-6ralcn8p	395	1	Today	today	NN
cord-012418-6ralcn8p	395	2	,	,	,
cord-012418-6ralcn8p	395	3	a	a	DT
cord-012418-6ralcn8p	395	4	long	long	JJ
cord-012418-6ralcn8p	395	5	list	list	NN
cord-012418-6ralcn8p	395	6	of	of	IN
cord-012418-6ralcn8p	395	7	viral	viral	JJ
cord-012418-6ralcn8p	395	8	factors	factor	NNS
cord-012418-6ralcn8p	395	9	targeting	target	VBG
cord-012418-6ralcn8p	395	10	every	every	DT
cord-012418-6ralcn8p	395	11	step	step	NN
cord-012418-6ralcn8p	395	12	from	from	IN
cord-012418-6ralcn8p	395	13	the	the	DT
cord-012418-6ralcn8p	395	14	stimulation	stimulation	NN
cord-012418-6ralcn8p	395	15	of	of	IN
cord-012418-6ralcn8p	395	16	PRRs	prr	NNS
cord-012418-6ralcn8p	395	17	by	by	IN
cord-012418-6ralcn8p	395	18	nucleic	nucleic	JJ
cord-012418-6ralcn8p	395	19	acids	acid	NNS
cord-012418-6ralcn8p	395	20	,	,	,
cord-012418-6ralcn8p	395	21	to	to	IN
cord-012418-6ralcn8p	395	22	induction	induction	NN
cord-012418-6ralcn8p	395	23	of	of	IN
cord-012418-6ralcn8p	395	24	transcription	transcription	NN
cord-012418-6ralcn8p	395	25	factor	factor	NN
cord-012418-6ralcn8p	395	26	activation	activation	NN
cord-012418-6ralcn8p	395	27	,	,	,
cord-012418-6ralcn8p	395	28	to	to	IN
cord-012418-6ralcn8p	395	29	activity	activity	NN
cord-012418-6ralcn8p	395	30	of	of	IN
cord-012418-6ralcn8p	395	31	IFN	IFN	NNP
cord-012418-6ralcn8p	395	32	,	,	,
cord-012418-6ralcn8p	395	33	through	through	IN
cord-012418-6ralcn8p	395	34	to	to	IN
cord-012418-6ralcn8p	395	35	the	the	DT
cord-012418-6ralcn8p	395	36	stimulation	stimulation	NN
cord-012418-6ralcn8p	395	37	and	and	CC
cord-012418-6ralcn8p	395	38	activity	activity	NN
cord-012418-6ralcn8p	395	39	of	of	IN
cord-012418-6ralcn8p	395	40	ISGs	isg	NNS
cord-012418-6ralcn8p	395	41	are	be	VBP
cord-012418-6ralcn8p	395	42	known	know	VBN
cord-012418-6ralcn8p	395	43	,	,	,
cord-012418-6ralcn8p	395	44	and	and	CC
cord-012418-6ralcn8p	395	45	the	the	DT
cord-012418-6ralcn8p	395	46	list	list	NN
cord-012418-6ralcn8p	395	47	still	still	RB
cord-012418-6ralcn8p	395	48	grows	grow	VBZ
cord-012418-6ralcn8p	395	49	[	[	-LRB-
cord-012418-6ralcn8p	395	50	177	177	CD
cord-012418-6ralcn8p	395	51	]	]	-RRB-
cord-012418-6ralcn8p	395	52	[	[	-LRB-
cord-012418-6ralcn8p	395	53	178	178	CD
cord-012418-6ralcn8p	395	54	]	]	-RRB-
cord-012418-6ralcn8p	395	55	[	[	-LRB-
cord-012418-6ralcn8p	395	56	179	179	CD
cord-012418-6ralcn8p	395	57	]	]	-RRB-
cord-012418-6ralcn8p	396	1	[	[	-LRB-
cord-012418-6ralcn8p	396	2	180	180	CD
cord-012418-6ralcn8p	396	3	]	]	-RRB-
cord-012418-6ralcn8p	396	4	[	[	-LRB-
cord-012418-6ralcn8p	396	5	181	181	CD
cord-012418-6ralcn8p	396	6	]	]	-RRB-
cord-012418-6ralcn8p	396	7	[	[	-LRB-
cord-012418-6ralcn8p	396	8	182	182	CD
cord-012418-6ralcn8p	396	9	]	]	-RRB-
cord-012418-6ralcn8p	396	10	[	[	-LRB-
cord-012418-6ralcn8p	396	11	183	183	CD
cord-012418-6ralcn8p	396	12	]	]	-RRB-
cord-012418-6ralcn8p	396	13	[	[	-LRB-
cord-012418-6ralcn8p	396	14	184	184	CD
cord-012418-6ralcn8p	396	15	]	]	-RRB-
cord-012418-6ralcn8p	396	16	.	.	.
cord-012418-6ralcn8p	397	1	The	the	DT
cord-012418-6ralcn8p	397	2	central	central	JJ
cord-012418-6ralcn8p	397	3	role	role	NN
cord-012418-6ralcn8p	397	4	of	of	IN
cord-012418-6ralcn8p	397	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	397	6	in	in	IN
cord-012418-6ralcn8p	397	7	this	this	DT
cord-012418-6ralcn8p	397	8	pathway	pathway	NN
cord-012418-6ralcn8p	397	9	makes	make	VBZ
cord-012418-6ralcn8p	397	10	it	-PRON-	PRP
cord-012418-6ralcn8p	397	11	an	an	DT
cord-012418-6ralcn8p	397	12	attractive	attractive	JJ
cord-012418-6ralcn8p	397	13	target	target	NN
cord-012418-6ralcn8p	397	14	for	for	IN
cord-012418-6ralcn8p	397	15	viral	viral	JJ
cord-012418-6ralcn8p	397	16	evasion	evasion	NN
cord-012418-6ralcn8p	397	17	.	.	.
cord-012418-6ralcn8p	398	1	Strategies	strategy	NNS
cord-012418-6ralcn8p	398	2	applied	apply	VBD
cord-012418-6ralcn8p	398	3	to	to	TO
cord-012418-6ralcn8p	398	4	interfere	interfere	VB
cord-012418-6ralcn8p	398	5	with	with	IN
cord-012418-6ralcn8p	398	6	the	the	DT
cord-012418-6ralcn8p	398	7	activation	activation	NN
cord-012418-6ralcn8p	398	8	of	of	IN
cord-012418-6ralcn8p	398	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	398	10	in	in	IN
cord-012418-6ralcn8p	398	11	the	the	DT
cord-012418-6ralcn8p	398	12	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	398	13	include	include	VBP
cord-012418-6ralcn8p	398	14	(	(	-LRB-
cord-012418-6ralcn8p	398	15	i	i	NN
cord-012418-6ralcn8p	398	16	)	)	-RRB-
cord-012418-6ralcn8p	399	1	the	the	DT
cord-012418-6ralcn8p	399	2	inhibition	inhibition	NN
cord-012418-6ralcn8p	399	3	of	of	IN
cord-012418-6ralcn8p	399	4	IRF3	IRF3	NNP
cord-012418-6ralcn8p	399	5	expression	expression	NN
cord-012418-6ralcn8p	399	6	;	;	:
cord-012418-6ralcn8p	399	7	(	(	-LRB-
cord-012418-6ralcn8p	399	8	ii	ii	NN
cord-012418-6ralcn8p	399	9	)	)	-RRB-
cord-012418-6ralcn8p	399	10	direct	direct	JJ
cord-012418-6ralcn8p	399	11	antagonism	antagonism	NN
cord-012418-6ralcn8p	399	12	of	of	IN
cord-012418-6ralcn8p	399	13	essential	essential	JJ
cord-012418-6ralcn8p	399	14	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	399	15	events	event	NNS
cord-012418-6ralcn8p	399	16	by	by	IN
cord-012418-6ralcn8p	399	17	targeting	target	VBG
cord-012418-6ralcn8p	399	18	the	the	DT
cord-012418-6ralcn8p	399	19	essential	essential	JJ
cord-012418-6ralcn8p	399	20	kinases	kinase	NNS
cord-012418-6ralcn8p	399	21	,	,	,
cord-012418-6ralcn8p	399	22	their	-PRON-	PRP$
cord-012418-6ralcn8p	399	23	interaction	interaction	NN
cord-012418-6ralcn8p	399	24	with	with	IN
cord-012418-6ralcn8p	399	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	399	26	or	or	CC
cord-012418-6ralcn8p	399	27	dephosphorylating	dephosphorylate	VBG
cord-012418-6ralcn8p	399	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	399	29	(	(	-LRB-
cord-012418-6ralcn8p	399	30	recently	recently	RB
cord-012418-6ralcn8p	399	31	joined	join	VBN
cord-012418-6ralcn8p	399	32	by	by	IN
cord-012418-6ralcn8p	399	33	herpes	herpes	NNP
cord-012418-6ralcn8p	399	34	simplex	simplex	NNP
cord-012418-6ralcn8p	399	35	virus	virus	NN
cord-012418-6ralcn8p	400	1	(	(	-LRB-
cord-012418-6ralcn8p	400	2	HSV)-2	hsv)-2	NN
cord-012418-6ralcn8p	400	3	immediate	immediate	JJ
cord-012418-6ralcn8p	400	4	early	early	JJ
cord-012418-6ralcn8p	400	5	protein	protein	NN
cord-012418-6ralcn8p	401	1	ICP27	ICP27	NNP
cord-012418-6ralcn8p	401	2	[	[	-LRB-
cord-012418-6ralcn8p	401	3	185	185	CD
cord-012418-6ralcn8p	401	4	]	]	-RRB-
cord-012418-6ralcn8p	401	5	,	,	,
cord-012418-6ralcn8p	401	6	and	and	CC
cord-012418-6ralcn8p	401	7	the	the	DT
cord-012418-6ralcn8p	401	8	nucleocapsid	nucleocapsid	NNP
cord-012418-6ralcn8p	401	9	protein	protein	NN
cord-012418-6ralcn8p	401	10	of	of	IN
cord-012418-6ralcn8p	401	11	Peste	Peste	NNP
cord-012418-6ralcn8p	401	12	des	des	FW
cord-012418-6ralcn8p	401	13	petits	petit	NNS
cord-012418-6ralcn8p	401	14	ruminants	ruminant	NNS
cord-012418-6ralcn8p	401	15	virus	virus	NN
cord-012418-6ralcn8p	401	16	[	[	-LRB-
cord-012418-6ralcn8p	401	17	186	186	CD
cord-012418-6ralcn8p	401	18	]	]	-RRB-
cord-012418-6ralcn8p	401	19	)	)	-RRB-
cord-012418-6ralcn8p	401	20	;	;	:
cord-012418-6ralcn8p	401	21	and	and	CC
cord-012418-6ralcn8p	401	22	(	(	-LRB-
cord-012418-6ralcn8p	401	23	iii	iii	NN
cord-012418-6ralcn8p	401	24	)	)	-RRB-
cord-012418-6ralcn8p	401	25	mediating	mediate	VBG
cord-012418-6ralcn8p	401	26	degradation	degradation	NN
cord-012418-6ralcn8p	401	27	of	of	IN
cord-012418-6ralcn8p	401	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	401	29	.	.	.
cord-012418-6ralcn8p	402	1	Remarkably	remarkably	RB
cord-012418-6ralcn8p	402	2	,	,	,
cord-012418-6ralcn8p	402	3	even	even	RB
cord-012418-6ralcn8p	402	4	nuclear	nuclear	JJ
cord-012418-6ralcn8p	402	5	phosphorylated	phosphorylate	VBD
cord-012418-6ralcn8p	402	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	402	7	can	can	MD
cord-012418-6ralcn8p	402	8	specifically	specifically	RB
cord-012418-6ralcn8p	402	9	be	be	VB
cord-012418-6ralcn8p	402	10	targeted	target	VBN
cord-012418-6ralcn8p	402	11	for	for	IN
cord-012418-6ralcn8p	402	12	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	402	13	and	and	CC
cord-012418-6ralcn8p	402	14	proteasome	proteasome	NN
cord-012418-6ralcn8p	402	15	-	-	HYPH
cord-012418-6ralcn8p	402	16	mediated	mediate	VBN
cord-012418-6ralcn8p	402	17	degradation	degradation	NN
cord-012418-6ralcn8p	402	18	after	after	IN
cord-012418-6ralcn8p	402	19	activation	activation	NN
cord-012418-6ralcn8p	402	20	[	[	-LRB-
cord-012418-6ralcn8p	402	21	187	187	CD
cord-012418-6ralcn8p	402	22	]	]	-RRB-
cord-012418-6ralcn8p	402	23	.	.	.
cord-012418-6ralcn8p	403	1	Other	other	JJ
cord-012418-6ralcn8p	403	2	viral	viral	JJ
cord-012418-6ralcn8p	403	3	factors	factor	NNS
cord-012418-6ralcn8p	403	4	aim	aim	VBP
cord-012418-6ralcn8p	403	5	to	to	TO
cord-012418-6ralcn8p	403	6	evade	evade	VB
cord-012418-6ralcn8p	403	7	the	the	DT
cord-012418-6ralcn8p	403	8	type	type	NN
cord-012418-6ralcn8p	403	9	I	-PRON-	PRP
cord-012418-6ralcn8p	403	10	IFN	IFN	NNP
cord-012418-6ralcn8p	403	11	response	response	NN
cord-012418-6ralcn8p	403	12	more	more	RBR
cord-012418-6ralcn8p	403	13	generally	generally	RB
cord-012418-6ralcn8p	403	14	by	by	IN
cord-012418-6ralcn8p	403	15	limiting	limit	VBG
cord-012418-6ralcn8p	403	16	its	-PRON-	PRP$
cord-012418-6ralcn8p	403	17	induction	induction	NN
cord-012418-6ralcn8p	403	18	,	,	,
cord-012418-6ralcn8p	403	19	affecting	affect	VBG
cord-012418-6ralcn8p	403	20	production	production	NN
cord-012418-6ralcn8p	403	21	of	of	IN
cord-012418-6ralcn8p	403	22	IFN	IFN	NNP
cord-012418-6ralcn8p	403	23	by	by	IN
cord-012418-6ralcn8p	403	24	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	403	25	or	or	CC
cord-012418-6ralcn8p	403	26	translational	translational	JJ
cord-012418-6ralcn8p	403	27	shut	shut	NN
cord-012418-6ralcn8p	403	28	-	-	HYPH
cord-012418-6ralcn8p	403	29	off	off	NN
cord-012418-6ralcn8p	403	30	or	or	CC
cord-012418-6ralcn8p	403	31	dysregulating	dysregulate	VBG
cord-012418-6ralcn8p	403	32	the	the	DT
cord-012418-6ralcn8p	403	33	processing	processing	NN
cord-012418-6ralcn8p	403	34	or	or	CC
cord-012418-6ralcn8p	403	35	trafficking	trafficking	NN
cord-012418-6ralcn8p	403	36	of	of	IN
cord-012418-6ralcn8p	403	37	host	host	NN
cord-012418-6ralcn8p	403	38	mRNAs	mRNAs	.
cord-012418-6ralcn8p	404	1	[	[	-LRB-
cord-012418-6ralcn8p	404	2	188	188	CD
cord-012418-6ralcn8p	404	3	,	,	,
cord-012418-6ralcn8p	404	4	189	189	CD
cord-012418-6ralcn8p	404	5	]	]	-RRB-
cord-012418-6ralcn8p	404	6	.	.	.
cord-012418-6ralcn8p	405	1	Noting	note	VBG
cord-012418-6ralcn8p	405	2	that	that	IN
cord-012418-6ralcn8p	405	3	strategies	strategy	NNS
cord-012418-6ralcn8p	405	4	to	to	TO
cord-012418-6ralcn8p	405	5	inhibit	inhibit	VB
cord-012418-6ralcn8p	405	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	405	7	activation	activation	NN
cord-012418-6ralcn8p	405	8	and	and	CC
cord-012418-6ralcn8p	405	9	activity	activity	NN
cord-012418-6ralcn8p	405	10	applied	apply	VBN
cord-012418-6ralcn8p	405	11	by	by	IN
cord-012418-6ralcn8p	405	12	viruses	virus	NNS
cord-012418-6ralcn8p	405	13	were	be	VBD
cord-012418-6ralcn8p	405	14	frequently	frequently	RB
cord-012418-6ralcn8p	405	15	reviewed	review	VBN
cord-012418-6ralcn8p	405	16	for	for	IN
cord-012418-6ralcn8p	405	17	specific	specific	JJ
cord-012418-6ralcn8p	405	18	virus	virus	NN
cord-012418-6ralcn8p	405	19	families	family	NNS
cord-012418-6ralcn8p	405	20	as	as	RB
cord-012418-6ralcn8p	405	21	well	well	RB
cord-012418-6ralcn8p	405	22	as	as	IN
cord-012418-6ralcn8p	405	23	in	in	IN
cord-012418-6ralcn8p	405	24	broad	broad	JJ
cord-012418-6ralcn8p	405	25	summaries	summary	NNS
cord-012418-6ralcn8p	405	26	[	[	-LRB-
cord-012418-6ralcn8p	405	27	190	190	CD
cord-012418-6ralcn8p	405	28	]	]	-RRB-
cord-012418-6ralcn8p	405	29	[	[	-LRB-
cord-012418-6ralcn8p	405	30	191	191	CD
cord-012418-6ralcn8p	405	31	]	]	-RRB-
cord-012418-6ralcn8p	405	32	[	[	-LRB-
cord-012418-6ralcn8p	405	33	192	192	CD
cord-012418-6ralcn8p	405	34	]	]	-RRB-
cord-012418-6ralcn8p	405	35	[	[	-LRB-
cord-012418-6ralcn8p	405	36	193	193	CD
cord-012418-6ralcn8p	405	37	]	]	-RRB-
cord-012418-6ralcn8p	405	38	[	[	-LRB-
cord-012418-6ralcn8p	405	39	194	194	CD
cord-012418-6ralcn8p	405	40	]	]	-RRB-
cord-012418-6ralcn8p	405	41	[	[	-LRB-
cord-012418-6ralcn8p	405	42	195	195	CD
cord-012418-6ralcn8p	405	43	]	]	-RRB-
cord-012418-6ralcn8p	405	44	,	,	,
cord-012418-6ralcn8p	405	45	we	-PRON-	PRP
cord-012418-6ralcn8p	405	46	want	want	VBP
cord-012418-6ralcn8p	405	47	to	to	TO
cord-012418-6ralcn8p	405	48	emphasize	emphasize	VB
cord-012418-6ralcn8p	405	49	here	here	RB
cord-012418-6ralcn8p	405	50	the	the	DT
cord-012418-6ralcn8p	405	51	molecular	molecular	JJ
cord-012418-6ralcn8p	405	52	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	405	53	viruses	virus	NNS
cord-012418-6ralcn8p	405	54	deploy	deploy	VBP
cord-012418-6ralcn8p	405	55	to	to	TO
cord-012418-6ralcn8p	405	56	obstruct	obstruct	VB
cord-012418-6ralcn8p	405	57	the	the	DT
cord-012418-6ralcn8p	405	58	function	function	NN
cord-012418-6ralcn8p	405	59	of	of	IN
cord-012418-6ralcn8p	405	60	IRF3	IRF3	NNP
cord-012418-6ralcn8p	405	61	after	after	IN
cord-012418-6ralcn8p	405	62	its	-PRON-	PRP$
cord-012418-6ralcn8p	405	63	trans	trans	JJ
cord-012418-6ralcn8p	405	64	-	-	NN
cord-012418-6ralcn8p	405	65	activation	activation	JJ
cord-012418-6ralcn8p	405	66	potential	potential	NN
cord-012418-6ralcn8p	405	67	is	be	VBZ
cord-012418-6ralcn8p	405	68	enabled	enable	VBN
cord-012418-6ralcn8p	405	69	by	by	IN
cord-012418-6ralcn8p	405	70	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	405	71	(	(	-LRB-
cord-012418-6ralcn8p	405	72	Figure	figure	NN
cord-012418-6ralcn8p	405	73	4	4	CD
cord-012418-6ralcn8p	405	74	)	)	-RRB-
cord-012418-6ralcn8p	405	75	.	.	.
cord-012418-6ralcn8p	406	1	obstruct	obstruct	VB
cord-012418-6ralcn8p	406	2	the	the	DT
cord-012418-6ralcn8p	406	3	function	function	NN
cord-012418-6ralcn8p	406	4	of	of	IN
cord-012418-6ralcn8p	406	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	406	6	after	after	IN
cord-012418-6ralcn8p	406	7	its	-PRON-	PRP$
cord-012418-6ralcn8p	406	8	trans	trans	JJ
cord-012418-6ralcn8p	406	9	-	-	NN
cord-012418-6ralcn8p	406	10	activation	activation	JJ
cord-012418-6ralcn8p	406	11	potential	potential	NN
cord-012418-6ralcn8p	406	12	is	be	VBZ
cord-012418-6ralcn8p	406	13	enabled	enable	VBN
cord-012418-6ralcn8p	406	14	by	by	IN
cord-012418-6ralcn8p	406	15	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	406	16	(	(	-LRB-
cord-012418-6ralcn8p	406	17	Figure	figure	NN
cord-012418-6ralcn8p	406	18	4	4	CD
cord-012418-6ralcn8p	406	19	)	)	-RRB-
cord-012418-6ralcn8p	406	20	.	.	.
cord-012418-6ralcn8p	406	21	 	 	_SP
cord-012418-6ralcn8p	407	1	As	as	IN
cord-012418-6ralcn8p	407	2	the	the	DT
cord-012418-6ralcn8p	407	3	activation	activation	NN
cord-012418-6ralcn8p	407	4	of	of	IN
cord-012418-6ralcn8p	407	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	407	6	is	be	VBZ
cord-012418-6ralcn8p	407	7	a	a	DT
cord-012418-6ralcn8p	407	8	multistep	multistep	JJ
cord-012418-6ralcn8p	407	9	process	process	NN
cord-012418-6ralcn8p	407	10	,	,	,
cord-012418-6ralcn8p	407	11	in	in	IN
cord-012418-6ralcn8p	407	12	early	early	JJ
cord-012418-6ralcn8p	407	13	studies	study	NNS
cord-012418-6ralcn8p	407	14	the	the	DT
cord-012418-6ralcn8p	407	15	exact	exact	JJ
cord-012418-6ralcn8p	407	16	level	level	NN
cord-012418-6ralcn8p	407	17	of	of	IN
cord-012418-6ralcn8p	407	18	viral	viral	JJ
cord-012418-6ralcn8p	407	19	interference	interference	NN
cord-012418-6ralcn8p	407	20	sometimes	sometimes	RB
cord-012418-6ralcn8p	407	21	remained	remain	VBD
cord-012418-6ralcn8p	407	22	elusive	elusive	JJ
cord-012418-6ralcn8p	407	23	.	.	.
cord-012418-6ralcn8p	408	1	Dimerisation	Dimerisation	NNP
cord-012418-6ralcn8p	408	2	of	of	IN
cord-012418-6ralcn8p	408	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	408	4	was	be	VBD
cord-012418-6ralcn8p	408	5	among	among	IN
cord-012418-6ralcn8p	408	6	the	the	DT
cord-012418-6ralcn8p	408	7	first	first	JJ
cord-012418-6ralcn8p	408	8	steps	step	NNS
cord-012418-6ralcn8p	408	9	reported	report	VBN
cord-012418-6ralcn8p	408	10	to	to	TO
cord-012418-6ralcn8p	408	11	be	be	VB
cord-012418-6ralcn8p	408	12	targeted	target	VBN
cord-012418-6ralcn8p	408	13	in	in	IN
cord-012418-6ralcn8p	408	14	order	order	NN
cord-012418-6ralcn8p	408	15	to	to	TO
cord-012418-6ralcn8p	408	16	antagonize	antagonize	VB
cord-012418-6ralcn8p	408	17	its	-PRON-	PRP$
cord-012418-6ralcn8p	408	18	trans	trans	JJ
cord-012418-6ralcn8p	408	19	-	-	JJ
cord-012418-6ralcn8p	408	20	activation	activation	JJ
cord-012418-6ralcn8p	408	21	activity	activity	NN
cord-012418-6ralcn8p	408	22	.	.	.
cord-012418-6ralcn8p	409	1	The	the	DT
cord-012418-6ralcn8p	409	2	ML	ML	NNP
cord-012418-6ralcn8p	409	3	protein	protein	NN
cord-012418-6ralcn8p	409	4	,	,	,
cord-012418-6ralcn8p	409	5	a	a	DT
cord-012418-6ralcn8p	409	6	splice	splice	NN
cord-012418-6ralcn8p	409	7	variant	variant	NN
cord-012418-6ralcn8p	409	8	of	of	IN
cord-012418-6ralcn8p	409	9	the	the	DT
cord-012418-6ralcn8p	409	10	matrix	matrix	NN
cord-012418-6ralcn8p	409	11	protein	protein	NN
cord-012418-6ralcn8p	409	12	of	of	IN
cord-012418-6ralcn8p	409	13	Thogoto	Thogoto	NNP
cord-012418-6ralcn8p	409	14	virus	virus	NN
cord-012418-6ralcn8p	409	15	(	(	-LRB-
cord-012418-6ralcn8p	409	16	THOV	THOV	NNP
cord-012418-6ralcn8p	409	17	)	)	-RRB-
cord-012418-6ralcn8p	409	18	of	of	IN
cord-012418-6ralcn8p	409	19	the	the	DT
cord-012418-6ralcn8p	409	20	family	family	NN
cord-012418-6ralcn8p	409	21	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-012418-6ralcn8p	409	22	,	,	,
cord-012418-6ralcn8p	409	23	blocks	block	VBZ
cord-012418-6ralcn8p	409	24	the	the	DT
cord-012418-6ralcn8p	409	25	formation	formation	NN
cord-012418-6ralcn8p	409	26	of	of	IN
cord-012418-6ralcn8p	409	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	409	28	homodimers	homodimer	NNS
cord-012418-6ralcn8p	409	29	irrespective	irrespective	RB
cord-012418-6ralcn8p	409	30	of	of	IN
cord-012418-6ralcn8p	409	31	the	the	DT
cord-012418-6ralcn8p	409	32	presence	presence	NN
cord-012418-6ralcn8p	409	33	of	of	IN
cord-012418-6ralcn8p	409	34	the	the	DT
cord-012418-6ralcn8p	409	35	C	C	NNP
cord-012418-6ralcn8p	409	36	-	-	HYPH
cord-012418-6ralcn8p	409	37	terminal	terminal	NN
cord-012418-6ralcn8p	409	38	AIE	aie	NN
cord-012418-6ralcn8p	409	39	and	and	CC
cord-012418-6ralcn8p	409	40	further	further	RB
cord-012418-6ralcn8p	409	41	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	409	42	association	association	NN
cord-012418-6ralcn8p	409	43	of	of	IN
cord-012418-6ralcn8p	409	44	IRF3	IRF3	NNP
cord-012418-6ralcn8p	409	45	with	with	IN
cord-012418-6ralcn8p	409	46	CBP	CBP	NNP
cord-012418-6ralcn8p	409	47	[	[	-LRB-
cord-012418-6ralcn8p	409	48	196	196	CD
cord-012418-6ralcn8p	409	49	,	,	,
cord-012418-6ralcn8p	409	50	197	197	CD
cord-012418-6ralcn8p	409	51	]	]	-RRB-
cord-012418-6ralcn8p	409	52	.	.	.
cord-012418-6ralcn8p	410	1	Interestingly	interestingly	RB
cord-012418-6ralcn8p	410	2	,	,	,
cord-012418-6ralcn8p	410	3	this	this	DT
cord-012418-6ralcn8p	410	4	modulator	modulator	NN
cord-012418-6ralcn8p	410	5	does	do	VBZ
cord-012418-6ralcn8p	410	6	not	not	RB
cord-012418-6ralcn8p	410	7	affect	affect	VB
cord-012418-6ralcn8p	410	8	nuclear	nuclear	JJ
cord-012418-6ralcn8p	410	9	translocation	translocation	NN
cord-012418-6ralcn8p	410	10	,	,	,
cord-012418-6ralcn8p	410	11	suggesting	suggest	VBG
cord-012418-6ralcn8p	410	12	that	that	IN
cord-012418-6ralcn8p	410	13	ML	ML	NNP
cord-012418-6ralcn8p	410	14	does	do	VBZ
cord-012418-6ralcn8p	410	15	not	not	RB
cord-012418-6ralcn8p	410	16	disable	disable	VB
cord-012418-6ralcn8p	410	17	import	import	NN
cord-012418-6ralcn8p	410	18	of	of	IN
cord-012418-6ralcn8p	410	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	410	20	but	but	CC
cord-012418-6ralcn8p	410	21	renders	render	VBZ
cord-012418-6ralcn8p	410	22	otherwise	otherwise	RB
cord-012418-6ralcn8p	410	23	activated	activate	VBN
cord-012418-6ralcn8p	410	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	410	25	monomers	monomer	NNS
cord-012418-6ralcn8p	410	26	unable	unable	JJ
cord-012418-6ralcn8p	410	27	to	to	TO
cord-012418-6ralcn8p	410	28	participate	participate	VB
cord-012418-6ralcn8p	410	29	in	in	IN
cord-012418-6ralcn8p	410	30	further	further	JJ
cord-012418-6ralcn8p	410	31	interactions	interaction	NNS
cord-012418-6ralcn8p	410	32	in	in	IN
cord-012418-6ralcn8p	410	33	the	the	DT
cord-012418-6ralcn8p	410	34	nucleus	nucleus	NN
cord-012418-6ralcn8p	410	35	.	.	.
cord-012418-6ralcn8p	411	1	The	the	DT
cord-012418-6ralcn8p	411	2	authors	author	NNS
cord-012418-6ralcn8p	411	3	ruled	rule	VBD
cord-012418-6ralcn8p	411	4	out	out	RP
cord-012418-6ralcn8p	411	5	a	a	DT
cord-012418-6ralcn8p	411	6	lasting	last	VBG
cord-012418-6ralcn8p	411	7	interaction	interaction	NN
cord-012418-6ralcn8p	411	8	 	 	_SP
cord-012418-6ralcn8p	412	1	As	as	IN
cord-012418-6ralcn8p	412	2	the	the	DT
cord-012418-6ralcn8p	412	3	activation	activation	NN
cord-012418-6ralcn8p	412	4	of	of	IN
cord-012418-6ralcn8p	412	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	412	6	is	be	VBZ
cord-012418-6ralcn8p	412	7	a	a	DT
cord-012418-6ralcn8p	412	8	multistep	multistep	JJ
cord-012418-6ralcn8p	412	9	process	process	NN
cord-012418-6ralcn8p	412	10	,	,	,
cord-012418-6ralcn8p	412	11	in	in	IN
cord-012418-6ralcn8p	412	12	early	early	JJ
cord-012418-6ralcn8p	412	13	studies	study	NNS
cord-012418-6ralcn8p	412	14	the	the	DT
cord-012418-6ralcn8p	412	15	exact	exact	JJ
cord-012418-6ralcn8p	412	16	level	level	NN
cord-012418-6ralcn8p	412	17	of	of	IN
cord-012418-6ralcn8p	412	18	viral	viral	JJ
cord-012418-6ralcn8p	412	19	interference	interference	NN
cord-012418-6ralcn8p	412	20	sometimes	sometimes	RB
cord-012418-6ralcn8p	412	21	remained	remain	VBD
cord-012418-6ralcn8p	412	22	elusive	elusive	JJ
cord-012418-6ralcn8p	412	23	.	.	.
cord-012418-6ralcn8p	413	1	Dimerisation	Dimerisation	NNP
cord-012418-6ralcn8p	413	2	of	of	IN
cord-012418-6ralcn8p	413	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	413	4	was	be	VBD
cord-012418-6ralcn8p	413	5	among	among	IN
cord-012418-6ralcn8p	413	6	the	the	DT
cord-012418-6ralcn8p	413	7	first	first	JJ
cord-012418-6ralcn8p	413	8	steps	step	NNS
cord-012418-6ralcn8p	413	9	reported	report	VBN
cord-012418-6ralcn8p	413	10	to	to	TO
cord-012418-6ralcn8p	413	11	be	be	VB
cord-012418-6ralcn8p	413	12	targeted	target	VBN
cord-012418-6ralcn8p	413	13	in	in	IN
cord-012418-6ralcn8p	413	14	order	order	NN
cord-012418-6ralcn8p	413	15	to	to	TO
cord-012418-6ralcn8p	413	16	antagonize	antagonize	VB
cord-012418-6ralcn8p	413	17	its	-PRON-	PRP$
cord-012418-6ralcn8p	413	18	trans	trans	JJ
cord-012418-6ralcn8p	413	19	-	-	JJ
cord-012418-6ralcn8p	413	20	activation	activation	JJ
cord-012418-6ralcn8p	413	21	activity	activity	NN
cord-012418-6ralcn8p	413	22	.	.	.
cord-012418-6ralcn8p	414	1	The	the	DT
cord-012418-6ralcn8p	414	2	ML	ML	NNP
cord-012418-6ralcn8p	414	3	protein	protein	NN
cord-012418-6ralcn8p	414	4	,	,	,
cord-012418-6ralcn8p	414	5	a	a	DT
cord-012418-6ralcn8p	414	6	splice	splice	NN
cord-012418-6ralcn8p	414	7	variant	variant	NN
cord-012418-6ralcn8p	414	8	of	of	IN
cord-012418-6ralcn8p	414	9	the	the	DT
cord-012418-6ralcn8p	414	10	matrix	matrix	NN
cord-012418-6ralcn8p	414	11	protein	protein	NN
cord-012418-6ralcn8p	414	12	of	of	IN
cord-012418-6ralcn8p	414	13	Thogoto	Thogoto	NNP
cord-012418-6ralcn8p	414	14	virus	virus	NN
cord-012418-6ralcn8p	414	15	(	(	-LRB-
cord-012418-6ralcn8p	414	16	THOV	THOV	NNP
cord-012418-6ralcn8p	414	17	)	)	-RRB-
cord-012418-6ralcn8p	414	18	of	of	IN
cord-012418-6ralcn8p	414	19	the	the	DT
cord-012418-6ralcn8p	414	20	family	family	NN
cord-012418-6ralcn8p	414	21	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-012418-6ralcn8p	414	22	,	,	,
cord-012418-6ralcn8p	414	23	blocks	block	VBZ
cord-012418-6ralcn8p	414	24	the	the	DT
cord-012418-6ralcn8p	414	25	formation	formation	NN
cord-012418-6ralcn8p	414	26	of	of	IN
cord-012418-6ralcn8p	414	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	414	28	homodimers	homodimer	NNS
cord-012418-6ralcn8p	414	29	irrespective	irrespective	RB
cord-012418-6ralcn8p	414	30	of	of	IN
cord-012418-6ralcn8p	414	31	the	the	DT
cord-012418-6ralcn8p	414	32	presence	presence	NN
cord-012418-6ralcn8p	414	33	of	of	IN
cord-012418-6ralcn8p	414	34	the	the	DT
cord-012418-6ralcn8p	414	35	C	C	NNP
cord-012418-6ralcn8p	414	36	-	-	HYPH
cord-012418-6ralcn8p	414	37	terminal	terminal	NN
cord-012418-6ralcn8p	414	38	AIE	aie	NN
cord-012418-6ralcn8p	414	39	and	and	CC
cord-012418-6ralcn8p	414	40	further	further	RB
cord-012418-6ralcn8p	414	41	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	414	42	association	association	NN
cord-012418-6ralcn8p	414	43	of	of	IN
cord-012418-6ralcn8p	414	44	IRF3	IRF3	NNP
cord-012418-6ralcn8p	414	45	with	with	IN
cord-012418-6ralcn8p	414	46	CBP	CBP	NNP
cord-012418-6ralcn8p	414	47	[	[	-LRB-
cord-012418-6ralcn8p	414	48	196	196	CD
cord-012418-6ralcn8p	414	49	,	,	,
cord-012418-6ralcn8p	414	50	197	197	CD
cord-012418-6ralcn8p	414	51	]	]	-RRB-
cord-012418-6ralcn8p	414	52	.	.	.
cord-012418-6ralcn8p	415	1	Interestingly	interestingly	RB
cord-012418-6ralcn8p	415	2	,	,	,
cord-012418-6ralcn8p	415	3	this	this	DT
cord-012418-6ralcn8p	415	4	modulator	modulator	NN
cord-012418-6ralcn8p	415	5	does	do	VBZ
cord-012418-6ralcn8p	415	6	not	not	RB
cord-012418-6ralcn8p	415	7	affect	affect	VB
cord-012418-6ralcn8p	415	8	nuclear	nuclear	JJ
cord-012418-6ralcn8p	415	9	translocation	translocation	NN
cord-012418-6ralcn8p	415	10	,	,	,
cord-012418-6ralcn8p	415	11	suggesting	suggest	VBG
cord-012418-6ralcn8p	415	12	that	that	IN
cord-012418-6ralcn8p	415	13	ML	ML	NNP
cord-012418-6ralcn8p	415	14	does	do	VBZ
cord-012418-6ralcn8p	415	15	not	not	RB
cord-012418-6ralcn8p	415	16	disable	disable	VB
cord-012418-6ralcn8p	415	17	import	import	NN
cord-012418-6ralcn8p	415	18	of	of	IN
cord-012418-6ralcn8p	415	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	415	20	but	but	CC
cord-012418-6ralcn8p	415	21	renders	render	VBZ
cord-012418-6ralcn8p	415	22	otherwise	otherwise	RB
cord-012418-6ralcn8p	415	23	activated	activate	VBN
cord-012418-6ralcn8p	415	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	415	25	monomers	monomer	NNS
cord-012418-6ralcn8p	415	26	unable	unable	JJ
cord-012418-6ralcn8p	415	27	to	to	TO
cord-012418-6ralcn8p	415	28	participate	participate	VB
cord-012418-6ralcn8p	415	29	in	in	IN
cord-012418-6ralcn8p	415	30	further	further	JJ
cord-012418-6ralcn8p	415	31	interactions	interaction	NNS
cord-012418-6ralcn8p	415	32	in	in	IN
cord-012418-6ralcn8p	415	33	the	the	DT
cord-012418-6ralcn8p	415	34	nucleus	nucleus	NN
cord-012418-6ralcn8p	415	35	.	.	.
cord-012418-6ralcn8p	416	1	The	the	DT
cord-012418-6ralcn8p	416	2	authors	author	NNS
cord-012418-6ralcn8p	416	3	ruled	rule	VBD
cord-012418-6ralcn8p	416	4	out	out	RP
cord-012418-6ralcn8p	416	5	a	a	DT
cord-012418-6ralcn8p	416	6	lasting	last	VBG
cord-012418-6ralcn8p	416	7	interaction	interaction	NN
cord-012418-6ralcn8p	416	8	between	between	IN
cord-012418-6ralcn8p	416	9	ML	ML	NNP
cord-012418-6ralcn8p	416	10	and	and	CC
cord-012418-6ralcn8p	416	11	IRF3	IRF3	NNP
cord-012418-6ralcn8p	416	12	that	that	WDT
cord-012418-6ralcn8p	416	13	could	could	MD
cord-012418-6ralcn8p	416	14	for	for	IN
cord-012418-6ralcn8p	416	15	example	example	NN
cord-012418-6ralcn8p	416	16	directly	directly	RB
cord-012418-6ralcn8p	416	17	compete	compete	VB
cord-012418-6ralcn8p	416	18	with	with	IN
cord-012418-6ralcn8p	416	19	binding	bind	VBG
cord-012418-6ralcn8p	416	20	to	to	IN
cord-012418-6ralcn8p	416	21	CBP	CBP	NNP
cord-012418-6ralcn8p	416	22	/	/	SYM
cord-012418-6ralcn8p	416	23	p300	p300	NNP
cord-012418-6ralcn8p	416	24	because	because	IN
cord-012418-6ralcn8p	416	25	they	-PRON-	PRP
cord-012418-6ralcn8p	416	26	could	could	MD
cord-012418-6ralcn8p	416	27	not	not	RB
cord-012418-6ralcn8p	416	28	detect	detect	VB
cord-012418-6ralcn8p	416	29	association	association	NN
cord-012418-6ralcn8p	416	30	of	of	IN
cord-012418-6ralcn8p	416	31	ML	ML	NNP
cord-012418-6ralcn8p	416	32	and	and	CC
cord-012418-6ralcn8p	416	33	IRF3	IRF3	NNP
cord-012418-6ralcn8p	416	34	by	by	IN
cord-012418-6ralcn8p	416	35	co	co	NN
cord-012418-6ralcn8p	416	36	-	-	JJ
cord-012418-6ralcn8p	416	37	immunoprecipitation	immunoprecipitation	JJ
cord-012418-6ralcn8p	416	38	[	[	-LRB-
cord-012418-6ralcn8p	416	39	197	197	CD
cord-012418-6ralcn8p	416	40	]	]	-RRB-
cord-012418-6ralcn8p	416	41	.	.	.
cord-012418-6ralcn8p	417	1	Additionally	additionally	RB
cord-012418-6ralcn8p	417	2	,	,	,
cord-012418-6ralcn8p	417	3	ML	ML	NNP
cord-012418-6ralcn8p	417	4	interferes	interfere	VBZ
cord-012418-6ralcn8p	417	5	with	with	IN
cord-012418-6ralcn8p	417	6	a	a	DT
cord-012418-6ralcn8p	417	7	later	later	JJ
cord-012418-6ralcn8p	417	8	step	step	NN
cord-012418-6ralcn8p	417	9	in	in	IN
cord-012418-6ralcn8p	417	10	the	the	DT
cord-012418-6ralcn8p	417	11	induction	induction	NN
cord-012418-6ralcn8p	417	12	of	of	IN
cord-012418-6ralcn8p	417	13	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	417	14	expression	expression	NN
cord-012418-6ralcn8p	417	15	,	,	,
cord-012418-6ralcn8p	417	16	namely	namely	RB
cord-012418-6ralcn8p	417	17	,	,	,
cord-012418-6ralcn8p	417	18	the	the	DT
cord-012418-6ralcn8p	417	19	cofactor	cofactor	NN
cord-012418-6ralcn8p	417	20	function	function	NN
cord-012418-6ralcn8p	417	21	of	of	IN
cord-012418-6ralcn8p	417	22	TFIIB	TFIIB	NNP
cord-012418-6ralcn8p	417	23	at	at	IN
cord-012418-6ralcn8p	417	24	promoters	promoter	NNS
cord-012418-6ralcn8p	417	25	that	that	WDT
cord-012418-6ralcn8p	417	26	require	require	VBP
cord-012418-6ralcn8p	417	27	de	de	FW
cord-012418-6ralcn8p	417	28	novo	novo	NNP
cord-012418-6ralcn8p	417	29	recruitment	recruitment	NN
cord-012418-6ralcn8p	417	30	of	of	IN
cord-012418-6ralcn8p	417	31	RNAP	RNAP	NNP
cord-012418-6ralcn8p	417	32	II	II	NNP
cord-012418-6ralcn8p	417	33	,	,	,
cord-012418-6ralcn8p	417	34	which	which	WDT
cord-012418-6ralcn8p	417	35	was	be	VBD
cord-012418-6ralcn8p	417	36	indicated	indicate	VBN
cord-012418-6ralcn8p	417	37	by	by	IN
cord-012418-6ralcn8p	417	38	the	the	DT
cord-012418-6ralcn8p	417	39	finding	finding	NN
cord-012418-6ralcn8p	417	40	that	that	IN
cord-012418-6ralcn8p	417	41	ML	ML	NNP
cord-012418-6ralcn8p	417	42	also	also	RB
cord-012418-6ralcn8p	417	43	inhibited	inhibit	VBD
cord-012418-6ralcn8p	417	44	activity	activity	NN
cord-012418-6ralcn8p	417	45	of	of	IN
cord-012418-6ralcn8p	417	46	the	the	DT
cord-012418-6ralcn8p	417	47	constitutively	constitutively	RB
cord-012418-6ralcn8p	417	48	active	active	JJ
cord-012418-6ralcn8p	417	49	IRF3	IRF3	NNP
cord-012418-6ralcn8p	417	50	-	-	HYPH
cord-012418-6ralcn8p	417	51	5D	5d	NN
cord-012418-6ralcn8p	417	52	mutant	mutant	NN
cord-012418-6ralcn8p	417	53	[	[	-LRB-
cord-012418-6ralcn8p	417	54	198	198	CD
cord-012418-6ralcn8p	417	55	,	,	,
cord-012418-6ralcn8p	417	56	199	199	CD
cord-012418-6ralcn8p	417	57	]	]	-RRB-
cord-012418-6ralcn8p	417	58	.	.	.
cord-012418-6ralcn8p	418	1	The	the	DT
cord-012418-6ralcn8p	418	2	leader	leader	NN
cord-012418-6ralcn8p	418	3	(	(	-LRB-
cord-012418-6ralcn8p	418	4	L	L	NNP
cord-012418-6ralcn8p	418	5	)	)	-RRB-
cord-012418-6ralcn8p	418	6	protein	protein	NN
cord-012418-6ralcn8p	418	7	of	of	IN
cord-012418-6ralcn8p	418	8	the	the	DT
cord-012418-6ralcn8p	418	9	cardioviruses	cardioviruse	NNS
cord-012418-6ralcn8p	418	10	of	of	IN
cord-012418-6ralcn8p	418	11	the	the	DT
cord-012418-6ralcn8p	418	12	Picornaviridae	Picornaviridae	NNP
cord-012418-6ralcn8p	418	13	also	also	RB
cord-012418-6ralcn8p	418	14	interferes	interfere	VBZ
cord-012418-6ralcn8p	418	15	with	with	IN
cord-012418-6ralcn8p	418	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	418	17	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	418	18	.	.	.
cord-012418-6ralcn8p	419	1	In	in	IN
cord-012418-6ralcn8p	419	2	fact	fact	NN
cord-012418-6ralcn8p	419	3	,	,	,
cord-012418-6ralcn8p	419	4	at	at	IN
cord-012418-6ralcn8p	419	5	first	first	RB
cord-012418-6ralcn8p	419	6	,	,	,
cord-012418-6ralcn8p	419	7	the	the	DT
cord-012418-6ralcn8p	419	8	L	L	NNP
cord-012418-6ralcn8p	419	9	protein	protein	NN
cord-012418-6ralcn8p	419	10	of	of	IN
cord-012418-6ralcn8p	419	11	encephalomyocarditis	encephalomyocarditis	NNP
cord-012418-6ralcn8p	419	12	virus	virus	NN
cord-012418-6ralcn8p	419	13	(	(	-LRB-
cord-012418-6ralcn8p	419	14	EMCV	EMCV	NNP
cord-012418-6ralcn8p	419	15	)	)	-RRB-
cord-012418-6ralcn8p	419	16	was	be	VBD
cord-012418-6ralcn8p	419	17	reported	report	VBN
cord-012418-6ralcn8p	419	18	for	for	IN
cord-012418-6ralcn8p	419	19	its	-PRON-	PRP$
cord-012418-6ralcn8p	419	20	ability	ability	NN
cord-012418-6ralcn8p	419	21	to	to	TO
cord-012418-6ralcn8p	419	22	generally	generally	RB
cord-012418-6ralcn8p	419	23	disturb	disturb	VB
cord-012418-6ralcn8p	419	24	trafficking	trafficking	NN
cord-012418-6ralcn8p	419	25	of	of	IN
cord-012418-6ralcn8p	419	26	proteins	protein	NNS
cord-012418-6ralcn8p	419	27	between	between	IN
cord-012418-6ralcn8p	419	28	the	the	DT
cord-012418-6ralcn8p	419	29	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	419	30	and	and	CC
cord-012418-6ralcn8p	419	31	nucleus	nucleus	NN
cord-012418-6ralcn8p	419	32	[	[	-LRB-
cord-012418-6ralcn8p	419	33	200	200	CD
cord-012418-6ralcn8p	419	34	]	]	-RRB-
cord-012418-6ralcn8p	419	35	.	.	.
cord-012418-6ralcn8p	420	1	After	after	IN
cord-012418-6ralcn8p	420	2	infection	infection	NN
cord-012418-6ralcn8p	420	3	with	with	IN
cord-012418-6ralcn8p	420	4	a	a	DT
cord-012418-6ralcn8p	420	5	related	related	JJ
cord-012418-6ralcn8p	420	6	strain	strain	NN
cord-012418-6ralcn8p	420	7	,	,	,
cord-012418-6ralcn8p	420	8	Mengovirus	Mengovirus	NNP
cord-012418-6ralcn8p	420	9	,	,	,
cord-012418-6ralcn8p	420	10	however	however	RB
cord-012418-6ralcn8p	420	11	,	,	,
cord-012418-6ralcn8p	420	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	420	13	still	still	RB
cord-012418-6ralcn8p	420	14	localized	localize	VBD
cord-012418-6ralcn8p	420	15	to	to	IN
cord-012418-6ralcn8p	420	16	the	the	DT
cord-012418-6ralcn8p	420	17	nucleus	nucleus	NN
cord-012418-6ralcn8p	420	18	.	.	.
cord-012418-6ralcn8p	421	1	To	to	TO
cord-012418-6ralcn8p	421	2	inhibit	inhibit	VB
cord-012418-6ralcn8p	421	3	type	type	NN
cord-012418-6ralcn8p	421	4	I	-PRON-	PRP
cord-012418-6ralcn8p	421	5	IFN	IFN	NNP
cord-012418-6ralcn8p	421	6	transcription	transcription	NN
cord-012418-6ralcn8p	421	7	nonetheless	nonetheless	RB
cord-012418-6ralcn8p	421	8	,	,	,
cord-012418-6ralcn8p	421	9	the	the	DT
cord-012418-6ralcn8p	421	10	mengovirus	mengovirus	NNP
cord-012418-6ralcn8p	421	11	L	L	NNP
cord-012418-6ralcn8p	421	12	protein	protein	NN
cord-012418-6ralcn8p	421	13	antagonizes	antagonize	VBZ
cord-012418-6ralcn8p	421	14	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	421	15	of	of	IN
cord-012418-6ralcn8p	421	16	IRF3	IRF3	NNP
cord-012418-6ralcn8p	421	17	downstream	downstream	NN
cord-012418-6ralcn8p	421	18	of	of	IN
cord-012418-6ralcn8p	421	19	its	-PRON-	PRP$
cord-012418-6ralcn8p	421	20	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	421	21	[	[	-LRB-
cord-012418-6ralcn8p	421	22	201	201	CD
cord-012418-6ralcn8p	421	23	]	]	-RRB-
cord-012418-6ralcn8p	421	24	.	.	.
cord-012418-6ralcn8p	422	1	Due	due	IN
cord-012418-6ralcn8p	422	2	to	to	IN
cord-012418-6ralcn8p	422	3	the	the	DT
cord-012418-6ralcn8p	422	4	observation	observation	NN
cord-012418-6ralcn8p	422	5	of	of	IN
cord-012418-6ralcn8p	422	6	IRF3	IRF3	NNP
cord-012418-6ralcn8p	422	7	translocation	translocation	NN
cord-012418-6ralcn8p	422	8	without	without	IN
cord-012418-6ralcn8p	422	9	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	422	10	,	,	,
cord-012418-6ralcn8p	422	11	the	the	DT
cord-012418-6ralcn8p	422	12	authors	author	NNS
cord-012418-6ralcn8p	422	13	suggested	suggest	VBD
cord-012418-6ralcn8p	422	14	that	that	IN
cord-012418-6ralcn8p	422	15	importin	importin	NN
cord-012418-6ralcn8p	422	16	-	-	HYPH
cord-012418-6ralcn8p	422	17	mediated	mediate	VBN
cord-012418-6ralcn8p	422	18	transport	transport	NN
cord-012418-6ralcn8p	422	19	might	may	MD
cord-012418-6ralcn8p	422	20	be	be	VB
cord-012418-6ralcn8p	422	21	a	a	DT
cord-012418-6ralcn8p	422	22	requirement	requirement	NN
cord-012418-6ralcn8p	422	23	for	for	IN
cord-012418-6ralcn8p	422	24	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	422	25	of	of	IN
cord-012418-6ralcn8p	422	26	IRF3	IRF3	NNP
cord-012418-6ralcn8p	422	27	,	,	,
cord-012418-6ralcn8p	422	28	which	which	WDT
cord-012418-6ralcn8p	422	29	would	would	MD
cord-012418-6ralcn8p	422	30	take	take	VB
cord-012418-6ralcn8p	422	31	place	place	NN
cord-012418-6ralcn8p	422	32	within	within	IN
cord-012418-6ralcn8p	422	33	the	the	DT
cord-012418-6ralcn8p	422	34	nucleus	nucleus	NN
cord-012418-6ralcn8p	422	35	,	,	,
cord-012418-6ralcn8p	422	36	which	which	WDT
cord-012418-6ralcn8p	422	37	is	be	VBZ
cord-012418-6ralcn8p	422	38	in	in	IN
cord-012418-6ralcn8p	422	39	line	line	NN
cord-012418-6ralcn8p	422	40	with	with	IN
cord-012418-6ralcn8p	422	41	nuclear	nuclear	JJ
cord-012418-6ralcn8p	422	42	translocation	translocation	NN
cord-012418-6ralcn8p	422	43	of	of	IN
cord-012418-6ralcn8p	422	44	monomeric	monomeric	JJ
cord-012418-6ralcn8p	422	45	IRF3	IRF3	NNP
cord-012418-6ralcn8p	422	46	,	,	,
cord-012418-6ralcn8p	422	47	as	as	IN
cord-012418-6ralcn8p	422	48	discussed	discuss	VBN
cord-012418-6ralcn8p	422	49	above	above	RB
cord-012418-6ralcn8p	422	50	(	(	-LRB-
cord-012418-6ralcn8p	422	51	see	see	VB
cord-012418-6ralcn8p	422	52	Section	section	NN
cord-012418-6ralcn8p	422	53	2.3	2.3	CD
cord-012418-6ralcn8p	422	54	)	)	-RRB-
cord-012418-6ralcn8p	422	55	.	.	.
cord-012418-6ralcn8p	423	1	The	the	DT
cord-012418-6ralcn8p	423	2	L	L	NNP
cord-012418-6ralcn8p	423	3	protein	protein	NN
cord-012418-6ralcn8p	423	4	from	from	IN
cord-012418-6ralcn8p	423	5	a	a	DT
cord-012418-6ralcn8p	423	6	different	different	JJ
cord-012418-6ralcn8p	423	7	cardiovirus	cardiovirus	NNP
cord-012418-6ralcn8p	423	8	species	specie	NNS
cord-012418-6ralcn8p	423	9	,	,	,
cord-012418-6ralcn8p	423	10	Theiler	Theiler	NNP
cord-012418-6ralcn8p	423	11	's	's	POS
cord-012418-6ralcn8p	423	12	murine	murine	JJ
cord-012418-6ralcn8p	423	13	encephalomyelitis	encephalomyelitis	NN
cord-012418-6ralcn8p	423	14	virus	virus	NN
cord-012418-6ralcn8p	423	15	(	(	-LRB-
cord-012418-6ralcn8p	423	16	TMEV	TMEV	NNP
cord-012418-6ralcn8p	423	17	)	)	-RRB-
cord-012418-6ralcn8p	423	18	,	,	,
cord-012418-6ralcn8p	423	19	also	also	RB
cord-012418-6ralcn8p	423	20	interferes	interfere	VBZ
cord-012418-6ralcn8p	423	21	with	with	IN
cord-012418-6ralcn8p	423	22	the	the	DT
cord-012418-6ralcn8p	423	23	formation	formation	NN
cord-012418-6ralcn8p	423	24	of	of	IN
cord-012418-6ralcn8p	423	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	423	26	dimers	dimer	NNS
cord-012418-6ralcn8p	423	27	,	,	,
cord-012418-6ralcn8p	423	28	though	though	IN
cord-012418-6ralcn8p	423	29	it	-PRON-	PRP
cord-012418-6ralcn8p	423	30	was	be	VBD
cord-012418-6ralcn8p	423	31	first	first	RB
cord-012418-6ralcn8p	423	32	identified	identify	VBN
cord-012418-6ralcn8p	423	33	because	because	IN
cord-012418-6ralcn8p	423	34	it	-PRON-	PRP
cord-012418-6ralcn8p	423	35	additionally	additionally	RB
cord-012418-6ralcn8p	423	36	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	423	37	the	the	DT
cord-012418-6ralcn8p	423	38	nuclear	nuclear	JJ
cord-012418-6ralcn8p	423	39	translocation	translocation	NN
cord-012418-6ralcn8p	423	40	of	of	IN
cord-012418-6ralcn8p	423	41	IRF3	IRF3	NNP
cord-012418-6ralcn8p	423	42	[	[	-LRB-
cord-012418-6ralcn8p	423	43	202	202	CD
cord-012418-6ralcn8p	423	44	,	,	,
cord-012418-6ralcn8p	423	45	203	203	CD
cord-012418-6ralcn8p	423	46	]	]	-RRB-
cord-012418-6ralcn8p	423	47	.	.	.
cord-012418-6ralcn8p	424	1	This	this	DT
cord-012418-6ralcn8p	424	2	function	function	NN
cord-012418-6ralcn8p	424	3	depends	depend	VBZ
cord-012418-6ralcn8p	424	4	on	on	IN
cord-012418-6ralcn8p	424	5	the	the	DT
cord-012418-6ralcn8p	424	6	Zinc	zinc	NN
cord-012418-6ralcn8p	424	7	finger	finger	NN
cord-012418-6ralcn8p	424	8	motif	motif	NN
cord-012418-6ralcn8p	424	9	of	of	IN
cord-012418-6ralcn8p	424	10	L	l	NN
cord-012418-6ralcn8p	424	11	[	[	-LRB-
cord-012418-6ralcn8p	424	12	203	203	CD
cord-012418-6ralcn8p	424	13	]	]	-RRB-
cord-012418-6ralcn8p	424	14	,	,	,
cord-012418-6ralcn8p	424	15	but	but	CC
cord-012418-6ralcn8p	424	16	whether	whether	IN
cord-012418-6ralcn8p	424	17	L	l	NN
cord-012418-6ralcn8p	424	18	affects	affect	VBZ
cord-012418-6ralcn8p	424	19	preceding	precede	VBG
cord-012418-6ralcn8p	424	20	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	424	21	of	of	IN
cord-012418-6ralcn8p	424	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	424	23	as	as	RB
cord-012418-6ralcn8p	424	24	well	well	RB
cord-012418-6ralcn8p	424	25	remains	remain	VBZ
cord-012418-6ralcn8p	424	26	undetermined	undetermined	JJ
cord-012418-6ralcn8p	424	27	.	.	.
cord-012418-6ralcn8p	425	1	The	the	DT
cord-012418-6ralcn8p	425	2	strong	strong	JJ
cord-012418-6ralcn8p	425	3	impact	impact	NN
cord-012418-6ralcn8p	425	4	of	of	IN
cord-012418-6ralcn8p	425	5	L	l	NN
cord-012418-6ralcn8p	425	6	on	on	IN
cord-012418-6ralcn8p	425	7	the	the	DT
cord-012418-6ralcn8p	425	8	antiviral	antiviral	JJ
cord-012418-6ralcn8p	425	9	innate	innate	JJ
cord-012418-6ralcn8p	425	10	immune	immune	JJ
cord-012418-6ralcn8p	425	11	response	response	NN
cord-012418-6ralcn8p	425	12	is	be	VBZ
cord-012418-6ralcn8p	425	13	additionally	additionally	RB
cord-012418-6ralcn8p	425	14	accounted	account	VBN
cord-012418-6ralcn8p	425	15	for	for	IN
cord-012418-6ralcn8p	425	16	by	by	IN
cord-012418-6ralcn8p	425	17	the	the	DT
cord-012418-6ralcn8p	425	18	inhibition	inhibition	NN
cord-012418-6ralcn8p	425	19	of	of	IN
cord-012418-6ralcn8p	425	20	mRNA	mRNA	NNP
cord-012418-6ralcn8p	425	21	export	export	NN
cord-012418-6ralcn8p	425	22	from	from	IN
cord-012418-6ralcn8p	425	23	the	the	DT
cord-012418-6ralcn8p	425	24	nucleus	nucleus	NN
cord-012418-6ralcn8p	425	25	which	which	WDT
cord-012418-6ralcn8p	425	26	is	be	VBZ
cord-012418-6ralcn8p	425	27	achieved	achieve	VBN
cord-012418-6ralcn8p	425	28	by	by	IN
cord-012418-6ralcn8p	425	29	L	l	NN
cord-012418-6ralcn8p	425	30	-	-	HYPH
cord-012418-6ralcn8p	425	31	mediated	mediate	VBN
cord-012418-6ralcn8p	425	32	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	425	33	of	of	IN
cord-012418-6ralcn8p	425	34	nucleoporin	nucleoporin	NNP
cord-012418-6ralcn8p	425	35	98	98	CD
cord-012418-6ralcn8p	425	36	[	[	-LRB-
cord-012418-6ralcn8p	425	37	203	203	CD
cord-012418-6ralcn8p	425	38	]	]	-RRB-
cord-012418-6ralcn8p	425	39	.	.	.
cord-012418-6ralcn8p	426	1	In	in	IN
cord-012418-6ralcn8p	426	2	contrast	contrast	NN
cord-012418-6ralcn8p	426	3	to	to	IN
cord-012418-6ralcn8p	426	4	the	the	DT
cord-012418-6ralcn8p	426	5	yet	yet	RB
cord-012418-6ralcn8p	426	6	unclear	unclear	JJ
cord-012418-6ralcn8p	426	7	molecular	molecular	JJ
cord-012418-6ralcn8p	426	8	mechanism	mechanism	NN
cord-012418-6ralcn8p	426	9	of	of	IN
cord-012418-6ralcn8p	426	10	ML	ML	NNP
cord-012418-6ralcn8p	426	11	and	and	CC
cord-012418-6ralcn8p	426	12	L	L	NNP
cord-012418-6ralcn8p	426	13	,	,	,
cord-012418-6ralcn8p	426	14	an	an	DT
cord-012418-6ralcn8p	426	15	interesting	interesting	JJ
cord-012418-6ralcn8p	426	16	detail	detail	NN
cord-012418-6ralcn8p	426	17	of	of	IN
cord-012418-6ralcn8p	426	18	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	426	19	antagonism	antagonism	NN
cord-012418-6ralcn8p	426	20	was	be	VBD
cord-012418-6ralcn8p	426	21	described	describe	VBN
cord-012418-6ralcn8p	426	22	for	for	IN
cord-012418-6ralcn8p	426	23	the	the	DT
cord-012418-6ralcn8p	426	24	serine	serine	NN
cord-012418-6ralcn8p	426	25	/	/	SYM
cord-012418-6ralcn8p	426	26	threonine	threonine	NN
cord-012418-6ralcn8p	426	27	kinase	kinase	VBZ
cord-012418-6ralcn8p	426	28	US3	US3	NNP
cord-012418-6ralcn8p	426	29	of	of	IN
cord-012418-6ralcn8p	426	30	HSV-1	HSV-1	NNP
cord-012418-6ralcn8p	426	31	[	[	-LRB-
cord-012418-6ralcn8p	426	32	204	204	CD
cord-012418-6ralcn8p	426	33	]	]	-RRB-
cord-012418-6ralcn8p	426	34	.	.	.
cord-012418-6ralcn8p	427	1	US3	US3	NNP
cord-012418-6ralcn8p	427	2	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	427	3	IRF3	IRF3	NNP
cord-012418-6ralcn8p	427	4	at	at	IN
cord-012418-6ralcn8p	427	5	S175	S175	NNP
cord-012418-6ralcn8p	427	6	,	,	,
cord-012418-6ralcn8p	427	7	and	and	CC
cord-012418-6ralcn8p	427	8	this	this	DT
cord-012418-6ralcn8p	427	9	hyperphosphorylation	hyperphosphorylation	NN
cord-012418-6ralcn8p	427	10	interferes	interfere	VBZ
cord-012418-6ralcn8p	427	11	with	with	IN
cord-012418-6ralcn8p	427	12	both	both	CC
cord-012418-6ralcn8p	427	13	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	427	14	and	and	CC
cord-012418-6ralcn8p	427	15	nuclear	nuclear	JJ
cord-012418-6ralcn8p	427	16	translocation	translocation	NN
cord-012418-6ralcn8p	427	17	of	of	IN
cord-012418-6ralcn8p	427	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	427	19	.	.	.
cord-012418-6ralcn8p	428	1	As	as	IN
cord-012418-6ralcn8p	428	2	also	also	RB
cord-012418-6ralcn8p	428	3	activity	activity	NN
cord-012418-6ralcn8p	428	4	of	of	IN
cord-012418-6ralcn8p	428	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	428	6	-	-	HYPH
cord-012418-6ralcn8p	428	7	5D	5D	NNP
cord-012418-6ralcn8p	428	8	could	could	MD
cord-012418-6ralcn8p	428	9	be	be	VB
cord-012418-6ralcn8p	428	10	inhibited	inhibit	VBN
cord-012418-6ralcn8p	428	11	by	by	IN
cord-012418-6ralcn8p	428	12	co	co	NN
cord-012418-6ralcn8p	428	13	-	-	JJ
cord-012418-6ralcn8p	428	14	expressed	express	VBD
cord-012418-6ralcn8p	428	15	US3	US3	NNP
cord-012418-6ralcn8p	428	16	in	in	IN
cord-012418-6ralcn8p	428	17	a	a	DT
cord-012418-6ralcn8p	428	18	Luciferase	Luciferase	NNP
cord-012418-6ralcn8p	428	19	-	-	HYPH
cord-012418-6ralcn8p	428	20	based	base	VBN
cord-012418-6ralcn8p	428	21	reporter	reporter	NN
cord-012418-6ralcn8p	428	22	assay	assay	NN
cord-012418-6ralcn8p	428	23	,	,	,
cord-012418-6ralcn8p	428	24	the	the	DT
cord-012418-6ralcn8p	428	25	effect	effect	NN
cord-012418-6ralcn8p	428	26	of	of	IN
cord-012418-6ralcn8p	428	27	US3	US3	NNP
cord-012418-6ralcn8p	428	28	seems	seem	VBZ
cord-012418-6ralcn8p	428	29	independent	independent	JJ
cord-012418-6ralcn8p	428	30	of	of	IN
cord-012418-6ralcn8p	428	31	the	the	DT
cord-012418-6ralcn8p	428	32	activation	activation	NN
cord-012418-6ralcn8p	428	33	status	status	NN
cord-012418-6ralcn8p	428	34	.	.	.
cord-012418-6ralcn8p	429	1	This	this	DT
cord-012418-6ralcn8p	429	2	adds	add	VBZ
cord-012418-6ralcn8p	429	3	a	a	DT
cord-012418-6ralcn8p	429	4	further	further	JJ
cord-012418-6ralcn8p	429	5	phosphate	phosphate	NN
cord-012418-6ralcn8p	429	6	group	group	NN
cord-012418-6ralcn8p	429	7	to	to	IN
cord-012418-6ralcn8p	429	8	the	the	DT
cord-012418-6ralcn8p	429	9	posttranslational	posttranslational	JJ
cord-012418-6ralcn8p	429	10	modifications	modification	NNS
cord-012418-6ralcn8p	429	11	that	that	WDT
cord-012418-6ralcn8p	429	12	modulate	modulate	VBP
cord-012418-6ralcn8p	429	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	429	14	activity	activity	NN
cord-012418-6ralcn8p	429	15	and	and	CC
cord-012418-6ralcn8p	429	16	raises	raise	VBZ
cord-012418-6ralcn8p	429	17	the	the	DT
cord-012418-6ralcn8p	429	18	question	question	NN
cord-012418-6ralcn8p	429	19	whether	whether	IN
cord-012418-6ralcn8p	429	20	the	the	DT
cord-012418-6ralcn8p	429	21	cardiovirus	cardiovirus	NNP
cord-012418-6ralcn8p	429	22	L	L	NNP
cord-012418-6ralcn8p	429	23	proteins	protein	NNS
cord-012418-6ralcn8p	429	24	might	may	MD
cord-012418-6ralcn8p	429	25	also	also	RB
cord-012418-6ralcn8p	429	26	interfere	interfere	VB
cord-012418-6ralcn8p	429	27	with	with	IN
cord-012418-6ralcn8p	429	28	the	the	DT
cord-012418-6ralcn8p	429	29	formation	formation	NN
cord-012418-6ralcn8p	429	30	of	of	IN
cord-012418-6ralcn8p	429	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	429	32	dimers	dimer	NNS
cord-012418-6ralcn8p	429	33	via	via	IN
cord-012418-6ralcn8p	429	34	small	small	JJ
cord-012418-6ralcn8p	429	35	modifications	modification	NNS
cord-012418-6ralcn8p	429	36	,	,	,
cord-012418-6ralcn8p	429	37	just	just	RB
cord-012418-6ralcn8p	429	38	as	as	IN
cord-012418-6ralcn8p	429	39	TMEV	TMEV	NNP
cord-012418-6ralcn8p	429	40	L	L	NNP
cord-012418-6ralcn8p	429	41	mediates	mediate	VBZ
cord-012418-6ralcn8p	429	42	inhibition	inhibition	NN
cord-012418-6ralcn8p	429	43	of	of	IN
cord-012418-6ralcn8p	429	44	the	the	DT
cord-012418-6ralcn8p	429	45	nuclear	nuclear	JJ
cord-012418-6ralcn8p	429	46	pore	pore	NN
cord-012418-6ralcn8p	429	47	protein	protein	NN
cord-012418-6ralcn8p	429	48	by	by	IN
cord-012418-6ralcn8p	429	49	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	429	50	[	[	-LRB-
cord-012418-6ralcn8p	429	51	203	203	CD
cord-012418-6ralcn8p	429	52	]	]	-RRB-
cord-012418-6ralcn8p	429	53	.	.	.
cord-012418-6ralcn8p	430	1	The	the	DT
cord-012418-6ralcn8p	430	2	V	V	NNP
cord-012418-6ralcn8p	430	3	protein	protein	NN
cord-012418-6ralcn8p	430	4	of	of	IN
cord-012418-6ralcn8p	430	5	simian	simian	JJ
cord-012418-6ralcn8p	430	6	virus	virus	NN
cord-012418-6ralcn8p	430	7	5	5	CD
cord-012418-6ralcn8p	431	1	(	(	-LRB-
cord-012418-6ralcn8p	431	2	SV5	SV5	NNP
cord-012418-6ralcn8p	431	3	)	)	-RRB-
cord-012418-6ralcn8p	431	4	was	be	VBD
cord-012418-6ralcn8p	431	5	the	the	DT
cord-012418-6ralcn8p	431	6	first	first	JJ
cord-012418-6ralcn8p	431	7	reported	report	VBN
cord-012418-6ralcn8p	431	8	antagonist	antagonist	NN
cord-012418-6ralcn8p	431	9	of	of	IN
cord-012418-6ralcn8p	431	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	431	11	translocation	translocation	NN
cord-012418-6ralcn8p	431	12	[	[	-LRB-
cord-012418-6ralcn8p	431	13	205	205	CD
cord-012418-6ralcn8p	431	14	]	]	-RRB-
cord-012418-6ralcn8p	431	15	,	,	,
cord-012418-6ralcn8p	431	16	followed	follow	VBN
cord-012418-6ralcn8p	431	17	by	by	IN
cord-012418-6ralcn8p	431	18	the	the	DT
cord-012418-6ralcn8p	431	19	multifunctional	multifunctional	JJ
cord-012418-6ralcn8p	431	20	NS1	ns1	NN
cord-012418-6ralcn8p	431	21	protein	protein	NN
cord-012418-6ralcn8p	431	22	of	of	IN
cord-012418-6ralcn8p	431	23	Influenza	Influenza	NNP
cord-012418-6ralcn8p	431	24	B	B	NNP
cord-012418-6ralcn8p	431	25	virus	virus	NN
cord-012418-6ralcn8p	431	26	(	(	-LRB-
cord-012418-6ralcn8p	431	27	IBV	IBV	NNP
cord-012418-6ralcn8p	431	28	)	)	-RRB-
cord-012418-6ralcn8p	431	29	[	[	-LRB-
cord-012418-6ralcn8p	431	30	206	206	CD
cord-012418-6ralcn8p	431	31	]	]	-RRB-
cord-012418-6ralcn8p	431	32	and	and	CC
cord-012418-6ralcn8p	431	33	the	the	DT
cord-012418-6ralcn8p	431	34	L	L	NNP
cord-012418-6ralcn8p	431	35	protein	protein	NN
cord-012418-6ralcn8p	431	36	of	of	IN
cord-012418-6ralcn8p	431	37	TMEV	TMEV	NNP
cord-012418-6ralcn8p	431	38	[	[	-LRB-
cord-012418-6ralcn8p	431	39	202	202	CD
cord-012418-6ralcn8p	431	40	]	]	-RRB-
cord-012418-6ralcn8p	431	41	.	.	.
cord-012418-6ralcn8p	432	1	Again	again	RB
cord-012418-6ralcn8p	432	2	,	,	,
cord-012418-6ralcn8p	432	3	these	these	DT
cord-012418-6ralcn8p	432	4	early	early	JJ
cord-012418-6ralcn8p	432	5	studies	study	NNS
cord-012418-6ralcn8p	432	6	did	do	VBD
cord-012418-6ralcn8p	432	7	not	not	RB
cord-012418-6ralcn8p	432	8	yet	yet	RB
cord-012418-6ralcn8p	432	9	dissect	dissect	VB
cord-012418-6ralcn8p	432	10	which	which	WDT
cord-012418-6ralcn8p	432	11	form	form	NN
cord-012418-6ralcn8p	432	12	of	of	IN
cord-012418-6ralcn8p	432	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	432	14	is	be	VBZ
cord-012418-6ralcn8p	432	15	targeted	target	VBN
cord-012418-6ralcn8p	432	16	because	because	IN
cord-012418-6ralcn8p	432	17	the	the	DT
cord-012418-6ralcn8p	432	18	role	role	NN
cord-012418-6ralcn8p	432	19	of	of	IN
cord-012418-6ralcn8p	432	20	the	the	DT
cord-012418-6ralcn8p	432	21	essential	essential	JJ
cord-012418-6ralcn8p	432	22	modifications	modification	NNS
cord-012418-6ralcn8p	432	23	was	be	VBD
cord-012418-6ralcn8p	432	24	not	not	RB
cord-012418-6ralcn8p	432	25	known	know	VBN
cord-012418-6ralcn8p	432	26	in	in	IN
cord-012418-6ralcn8p	432	27	detail	detail	NN
cord-012418-6ralcn8p	432	28	.	.	.
cord-012418-6ralcn8p	433	1	Later	later	RB
cord-012418-6ralcn8p	433	2	reports	report	NNS
cord-012418-6ralcn8p	433	3	of	of	IN
cord-012418-6ralcn8p	433	4	viral	viral	JJ
cord-012418-6ralcn8p	433	5	antagonists	antagonist	NNS
cord-012418-6ralcn8p	433	6	of	of	IN
cord-012418-6ralcn8p	433	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	433	8	translocation	translocation	NN
cord-012418-6ralcn8p	433	9	then	then	RB
cord-012418-6ralcn8p	433	10	included	include	VBD
cord-012418-6ralcn8p	433	11	an	an	DT
cord-012418-6ralcn8p	433	12	assessment	assessment	NN
cord-012418-6ralcn8p	433	13	of	of	IN
cord-012418-6ralcn8p	433	14	the	the	DT
cord-012418-6ralcn8p	433	15	activation	activation	NN
cord-012418-6ralcn8p	433	16	state	state	NN
cord-012418-6ralcn8p	433	17	of	of	IN
cord-012418-6ralcn8p	433	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	433	19	,	,	,
cord-012418-6ralcn8p	433	20	and	and	CC
cord-012418-6ralcn8p	433	21	some	some	DT
cord-012418-6ralcn8p	433	22	were	be	VBD
cord-012418-6ralcn8p	433	23	found	find	VBN
cord-012418-6ralcn8p	433	24	to	to	TO
cord-012418-6ralcn8p	433	25	specifically	specifically	RB
cord-012418-6ralcn8p	433	26	target	target	VB
cord-012418-6ralcn8p	433	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	433	28	after	after	IN
cord-012418-6ralcn8p	433	29	its	-PRON-	PRP$
cord-012418-6ralcn8p	433	30	activation	activation	NN
cord-012418-6ralcn8p	433	31	.	.	.
cord-012418-6ralcn8p	434	1	For	for	IN
cord-012418-6ralcn8p	434	2	example	example	NN
cord-012418-6ralcn8p	434	3	,	,	,
cord-012418-6ralcn8p	434	4	HSV-1	hsv-1	NN
cord-012418-6ralcn8p	434	5	initially	initially	RB
cord-012418-6ralcn8p	434	6	stimulates	stimulate	VBZ
cord-012418-6ralcn8p	434	7	activation	activation	NN
cord-012418-6ralcn8p	434	8	of	of	IN
cord-012418-6ralcn8p	434	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	434	10	upon	upon	IN
cord-012418-6ralcn8p	434	11	entry	entry	NN
cord-012418-6ralcn8p	434	12	but	but	CC
cord-012418-6ralcn8p	434	13	subsequently	subsequently	RB
cord-012418-6ralcn8p	434	14	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	434	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	434	16	activity	activity	NN
cord-012418-6ralcn8p	434	17	by	by	IN
cord-012418-6ralcn8p	434	18	means	mean	NNS
cord-012418-6ralcn8p	434	19	of	of	IN
cord-012418-6ralcn8p	434	20	newly	newly	RB
cord-012418-6ralcn8p	434	21	synthesized	synthesize	VBN
cord-012418-6ralcn8p	434	22	infected	infected	JJ
cord-012418-6ralcn8p	434	23	cell	cell	NN
cord-012418-6ralcn8p	434	24	polypeptide	polypeptide	NN
cord-012418-6ralcn8p	434	25	0	0	CD
cord-012418-6ralcn8p	435	1	(	(	-LRB-
cord-012418-6ralcn8p	435	2	ICP0	ICP0	NNP
cord-012418-6ralcn8p	435	3	)	)	-RRB-
cord-012418-6ralcn8p	435	4	[	[	-LRB-
cord-012418-6ralcn8p	435	5	207	207	CD
cord-012418-6ralcn8p	435	6	]	]	-RRB-
cord-012418-6ralcn8p	435	7	.	.	.
cord-012418-6ralcn8p	436	1	During	during	IN
cord-012418-6ralcn8p	436	2	the	the	DT
cord-012418-6ralcn8p	436	3	viral	viral	JJ
cord-012418-6ralcn8p	436	4	replication	replication	NN
cord-012418-6ralcn8p	436	5	cycle	cycle	NN
cord-012418-6ralcn8p	436	6	,	,	,
cord-012418-6ralcn8p	436	7	a	a	DT
cord-012418-6ralcn8p	436	8	part	part	NN
cord-012418-6ralcn8p	436	9	of	of	IN
cord-012418-6ralcn8p	436	10	the	the	DT
cord-012418-6ralcn8p	436	11	multifunctional	multifunctional	JJ
cord-012418-6ralcn8p	436	12	ICP0	ICP0	NNP
cord-012418-6ralcn8p	436	13	molecules	molecule	NNS
cord-012418-6ralcn8p	436	14	localises	localise	NNS
cord-012418-6ralcn8p	436	15	to	to	IN
cord-012418-6ralcn8p	436	16	the	the	DT
cord-012418-6ralcn8p	436	17	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	436	18	and	and	CC
cord-012418-6ralcn8p	436	19	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	436	20	the	the	DT
cord-012418-6ralcn8p	436	21	translocation	translocation	NN
cord-012418-6ralcn8p	436	22	of	of	IN
cord-012418-6ralcn8p	436	23	activated	activate	VBN
cord-012418-6ralcn8p	436	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	436	25	into	into	IN
cord-012418-6ralcn8p	436	26	the	the	DT
cord-012418-6ralcn8p	436	27	nucleus	nucleus	NN
cord-012418-6ralcn8p	436	28	in	in	IN
cord-012418-6ralcn8p	436	29	order	order	NN
cord-012418-6ralcn8p	436	30	to	to	TO
cord-012418-6ralcn8p	436	31	shorten	shorten	VB
cord-012418-6ralcn8p	436	32	the	the	DT
cord-012418-6ralcn8p	436	33	ongoing	ongoing	JJ
cord-012418-6ralcn8p	436	34	IRF3-dependent	IRF3-dependent	NNP
cord-012418-6ralcn8p	436	35	innate	innate	JJ
cord-012418-6ralcn8p	436	36	immune	immune	JJ
cord-012418-6ralcn8p	436	37	response	response	NN
cord-012418-6ralcn8p	436	38	.	.	.
cord-012418-6ralcn8p	437	1	Curiously	curiously	RB
cord-012418-6ralcn8p	437	2	,	,	,
cord-012418-6ralcn8p	437	3	while	while	IN
cord-012418-6ralcn8p	437	4	this	this	DT
cord-012418-6ralcn8p	437	5	cytosolic	cytosolic	JJ
cord-012418-6ralcn8p	437	6	function	function	NN
cord-012418-6ralcn8p	437	7	of	of	IN
cord-012418-6ralcn8p	437	8	ICP0	ICP0	NNP
cord-012418-6ralcn8p	437	9	is	be	VBZ
cord-012418-6ralcn8p	437	10	independent	independent	JJ
cord-012418-6ralcn8p	437	11	of	of	IN
cord-012418-6ralcn8p	437	12	the	the	DT
cord-012418-6ralcn8p	437	13	activity	activity	NN
cord-012418-6ralcn8p	437	14	of	of	IN
cord-012418-6ralcn8p	437	15	its	-PRON-	PRP$
cord-012418-6ralcn8p	437	16	E3	e3	NN
cord-012418-6ralcn8p	437	17	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	437	18	ligase	ligase	NN
cord-012418-6ralcn8p	437	19	domain	domain	NN
cord-012418-6ralcn8p	437	20	,	,	,
cord-012418-6ralcn8p	437	21	the	the	DT
cord-012418-6ralcn8p	437	22	functional	functional	JJ
cord-012418-6ralcn8p	437	23	host	host	NN
cord-012418-6ralcn8p	437	24	proteasome	proteasome	NN
cord-012418-6ralcn8p	437	25	is	be	VBZ
cord-012418-6ralcn8p	437	26	required	require	VBN
cord-012418-6ralcn8p	437	27	for	for	IN
cord-012418-6ralcn8p	437	28	the	the	DT
cord-012418-6ralcn8p	437	29	localisation	localisation	NN
cord-012418-6ralcn8p	437	30	of	of	IN
cord-012418-6ralcn8p	437	31	ICP0	ICP0	NNP
cord-012418-6ralcn8p	437	32	to	to	IN
cord-012418-6ralcn8p	437	33	the	the	DT
cord-012418-6ralcn8p	437	34	cytoplasm	cytoplasm	NN
cord-012418-6ralcn8p	437	35	[	[	-LRB-
cord-012418-6ralcn8p	437	36	207	207	CD
cord-012418-6ralcn8p	437	37	]	]	-RRB-
cord-012418-6ralcn8p	437	38	.	.	.
cord-012418-6ralcn8p	438	1	The	the	DT
cord-012418-6ralcn8p	438	2	inhibitory	inhibitory	JJ
cord-012418-6ralcn8p	438	3	function	function	NN
cord-012418-6ralcn8p	438	4	on	on	IN
cord-012418-6ralcn8p	438	5	the	the	DT
cord-012418-6ralcn8p	438	6	innate	innate	JJ
cord-012418-6ralcn8p	438	7	immune	immune	JJ
cord-012418-6ralcn8p	438	8	response	response	NN
cord-012418-6ralcn8p	438	9	by	by	IN
cord-012418-6ralcn8p	438	10	the	the	DT
cord-012418-6ralcn8p	438	11	V	V	NNP
cord-012418-6ralcn8p	438	12	protein	protein	NN
cord-012418-6ralcn8p	438	13	of	of	IN
cord-012418-6ralcn8p	438	14	Sendai	Sendai	NNP
cord-012418-6ralcn8p	438	15	virus	virus	NN
cord-012418-6ralcn8p	438	16	(	(	-LRB-
cord-012418-6ralcn8p	438	17	SeV	sev	NN
cord-012418-6ralcn8p	438	18	)	)	-RRB-
cord-012418-6ralcn8p	438	19	was	be	VBD
cord-012418-6ralcn8p	438	20	first	first	RB
cord-012418-6ralcn8p	438	21	accounted	account	VBN
cord-012418-6ralcn8p	438	22	for	for	IN
cord-012418-6ralcn8p	438	23	by	by	IN
cord-012418-6ralcn8p	438	24	the	the	DT
cord-012418-6ralcn8p	438	25	interaction	interaction	NN
cord-012418-6ralcn8p	438	26	of	of	IN
cord-012418-6ralcn8p	438	27	V	v	NN
cord-012418-6ralcn8p	438	28	with	with	IN
cord-012418-6ralcn8p	438	29	the	the	DT
cord-012418-6ralcn8p	438	30	RNA	RNA	NNP
cord-012418-6ralcn8p	438	31	sensor	sensor	NN
cord-012418-6ralcn8p	438	32	melanoma	melanoma	NN
cord-012418-6ralcn8p	438	33	differentiation	differentiation	NN
cord-012418-6ralcn8p	438	34	-	-	HYPH
cord-012418-6ralcn8p	438	35	associated	associate	VBN
cord-012418-6ralcn8p	438	36	protein	protein	NN
cord-012418-6ralcn8p	438	37	5	5	CD
cord-012418-6ralcn8p	438	38	(	(	-LRB-
cord-012418-6ralcn8p	438	39	MDA5	MDA5	NNP
cord-012418-6ralcn8p	438	40	)	)	-RRB-
cord-012418-6ralcn8p	438	41	[	[	-LRB-
cord-012418-6ralcn8p	438	42	208	208	CD
cord-012418-6ralcn8p	438	43	]	]	-RRB-
cord-012418-6ralcn8p	438	44	.	.	.
cord-012418-6ralcn8p	439	1	However	however	RB
cord-012418-6ralcn8p	439	2	,	,	,
cord-012418-6ralcn8p	439	3	SeV	sev	NN
cord-012418-6ralcn8p	439	4	infection	infection	NN
cord-012418-6ralcn8p	439	5	is	be	VBZ
cord-012418-6ralcn8p	439	6	predominantly	predominantly	RB
cord-012418-6ralcn8p	439	7	detected	detect	VBN
cord-012418-6ralcn8p	439	8	by	by	IN
cord-012418-6ralcn8p	439	9	RIG	rig	NN
cord-012418-6ralcn8p	439	10	-	-	:
cord-012418-6ralcn8p	439	11	I	-PRON-	PRP
cord-012418-6ralcn8p	439	12	[	[	-LRB-
cord-012418-6ralcn8p	439	13	209	209	CD
cord-012418-6ralcn8p	439	14	]	]	-RRB-
cord-012418-6ralcn8p	439	15	[	[	-LRB-
cord-012418-6ralcn8p	439	16	210	210	CD
cord-012418-6ralcn8p	439	17	]	]	-RRB-
cord-012418-6ralcn8p	439	18	[	[	-LRB-
cord-012418-6ralcn8p	439	19	211	211	CD
cord-012418-6ralcn8p	439	20	]	]	-RRB-
cord-012418-6ralcn8p	439	21	,	,	,
cord-012418-6ralcn8p	439	22	and	and	CC
cord-012418-6ralcn8p	439	23	SeV	sev	NN
cord-012418-6ralcn8p	439	24	infection	infection	NN
cord-012418-6ralcn8p	439	25	still	still	RB
cord-012418-6ralcn8p	439	26	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	439	27	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	439	28	production	production	NN
cord-012418-6ralcn8p	439	29	in	in	IN
cord-012418-6ralcn8p	439	30	MDA5-knockout	MDA5-knockout	NNP
cord-012418-6ralcn8p	439	31	mice	mouse	NNS
cord-012418-6ralcn8p	439	32	[	[	-LRB-
cord-012418-6ralcn8p	439	33	212	212	CD
cord-012418-6ralcn8p	439	34	]	]	-RRB-
cord-012418-6ralcn8p	439	35	.	.	.
cord-012418-6ralcn8p	440	1	For	for	IN
cord-012418-6ralcn8p	440	2	this	this	DT
cord-012418-6ralcn8p	440	3	reason	reason	NN
cord-012418-6ralcn8p	440	4	,	,	,
cord-012418-6ralcn8p	440	5	the	the	DT
cord-012418-6ralcn8p	440	6	group	group	NN
cord-012418-6ralcn8p	440	7	of	of	IN
cord-012418-6ralcn8p	440	8	Sakaguchi	Sakaguchi	NNP
cord-012418-6ralcn8p	440	9	continued	continue	VBD
cord-012418-6ralcn8p	440	10	their	-PRON-	PRP$
cord-012418-6ralcn8p	440	11	studies	study	NNS
cord-012418-6ralcn8p	440	12	and	and	CC
cord-012418-6ralcn8p	440	13	discovered	discover	VBD
cord-012418-6ralcn8p	440	14	that	that	IN
cord-012418-6ralcn8p	440	15	the	the	DT
cord-012418-6ralcn8p	440	16	SeV	sev	NN
cord-012418-6ralcn8p	440	17	V	v	NN
cord-012418-6ralcn8p	440	18	protein	protein	NN
cord-012418-6ralcn8p	440	19	interacts	interact	VBZ
cord-012418-6ralcn8p	440	20	with	with	IN
cord-012418-6ralcn8p	440	21	IRF3	IRF3	NNP
cord-012418-6ralcn8p	440	22	as	as	RB
cord-012418-6ralcn8p	440	23	well	well	RB
cord-012418-6ralcn8p	440	24	as	as	IN
cord-012418-6ralcn8p	440	25	IRF3	IRF3	NNP
cord-012418-6ralcn8p	440	26	-	-	HYPH
cord-012418-6ralcn8p	440	27	5D	5D	NNP
cord-012418-6ralcn8p	440	28	in	in	IN
cord-012418-6ralcn8p	440	29	the	the	DT
cord-012418-6ralcn8p	440	30	cytosol	cytosol	NN
cord-012418-6ralcn8p	440	31	and	and	CC
cord-012418-6ralcn8p	440	32	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	440	33	nuclear	nuclear	JJ
cord-012418-6ralcn8p	440	34	translocation	translocation	NN
cord-012418-6ralcn8p	440	35	.	.	.
cord-012418-6ralcn8p	441	1	In	in	IN
cord-012418-6ralcn8p	441	2	line	line	NN
cord-012418-6ralcn8p	441	3	with	with	IN
cord-012418-6ralcn8p	441	4	this	this	DT
cord-012418-6ralcn8p	441	5	,	,	,
cord-012418-6ralcn8p	441	6	also	also	RB
cord-012418-6ralcn8p	441	7	the	the	DT
cord-012418-6ralcn8p	441	8	V	v	NN
cord-012418-6ralcn8p	441	9	proteins	protein	NNS
cord-012418-6ralcn8p	441	10	of	of	IN
cord-012418-6ralcn8p	441	11	the	the	DT
cord-012418-6ralcn8p	441	12	related	related	JJ
cord-012418-6ralcn8p	441	13	measles	measle	NNS
cord-012418-6ralcn8p	441	14	virus	virus	NN
cord-012418-6ralcn8p	441	15	(	(	-LRB-
cord-012418-6ralcn8p	441	16	MeV	MeV	NNP
cord-012418-6ralcn8p	441	17	)	)	-RRB-
cord-012418-6ralcn8p	441	18	and	and	CC
cord-012418-6ralcn8p	441	19	Newcastle	Newcastle	NNP
cord-012418-6ralcn8p	441	20	disease	disease	NN
cord-012418-6ralcn8p	441	21	virus	virus	NN
cord-012418-6ralcn8p	441	22	(	(	-LRB-
cord-012418-6ralcn8p	441	23	NDV	NDV	NNP
cord-012418-6ralcn8p	441	24	)	)	-RRB-
cord-012418-6ralcn8p	441	25	of	of	IN
cord-012418-6ralcn8p	441	26	the	the	DT
cord-012418-6ralcn8p	441	27	Paramyxoviridae	Paramyxoviridae	NNP
cord-012418-6ralcn8p	441	28	interact	interact	VBP
cord-012418-6ralcn8p	441	29	with	with	IN
cord-012418-6ralcn8p	441	30	IRF3	IRF3	NNP
cord-012418-6ralcn8p	441	31	and	and	CC
cord-012418-6ralcn8p	441	32	interfere	interfere	VB
cord-012418-6ralcn8p	441	33	with	with	IN
cord-012418-6ralcn8p	441	34	its	-PRON-	PRP$
cord-012418-6ralcn8p	441	35	trans	trans	JJ
cord-012418-6ralcn8p	441	36	-	-	JJ
cord-012418-6ralcn8p	441	37	activation	activation	JJ
cord-012418-6ralcn8p	441	38	activity	activity	NN
cord-012418-6ralcn8p	441	39	,	,	,
cord-012418-6ralcn8p	441	40	though	though	IN
cord-012418-6ralcn8p	441	41	MeV	MeV	NNP
cord-012418-6ralcn8p	441	42	V	V	NNP
cord-012418-6ralcn8p	441	43	seems	seem	VBZ
cord-012418-6ralcn8p	441	44	to	to	TO
cord-012418-6ralcn8p	441	45	target	target	VB
cord-012418-6ralcn8p	441	46	IRF3	IRF3	NNP
cord-012418-6ralcn8p	441	47	after	after	IN
cord-012418-6ralcn8p	441	48	nuclear	nuclear	JJ
cord-012418-6ralcn8p	441	49	translocation	translocation	NN
cord-012418-6ralcn8p	441	50	[	[	-LRB-
cord-012418-6ralcn8p	441	51	212	212	CD
cord-012418-6ralcn8p	441	52	]	]	-RRB-
cord-012418-6ralcn8p	441	53	.	.	.
cord-012418-6ralcn8p	442	1	In	in	IN
cord-012418-6ralcn8p	442	2	contrast	contrast	NN
cord-012418-6ralcn8p	442	3	,	,	,
cord-012418-6ralcn8p	442	4	the	the	DT
cord-012418-6ralcn8p	442	5	non	non	JJ
cord-012418-6ralcn8p	442	6	-	-	JJ
cord-012418-6ralcn8p	442	7	structural	structural	JJ
cord-012418-6ralcn8p	442	8	protein	protein	NN
cord-012418-6ralcn8p	442	9	NS5	ns5	JJ
cord-012418-6ralcn8p	442	10	of	of	IN
cord-012418-6ralcn8p	442	11	the	the	DT
cord-012418-6ralcn8p	442	12	Flavivirus	Flavivirus	NNP
cord-012418-6ralcn8p	442	13	Japanese	Japanese	NNP
cord-012418-6ralcn8p	442	14	encephalitis	encephalitis	RB
cord-012418-6ralcn8p	442	15	virus	virus	NN
cord-012418-6ralcn8p	442	16	(	(	-LRB-
cord-012418-6ralcn8p	442	17	JEV	JEV	NNP
cord-012418-6ralcn8p	442	18	)	)	-RRB-
cord-012418-6ralcn8p	442	19	suppresses	suppress	VBZ
cord-012418-6ralcn8p	442	20	import	import	NN
cord-012418-6ralcn8p	442	21	of	of	IN
cord-012418-6ralcn8p	442	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	442	23	indirectly	indirectly	RB
cord-012418-6ralcn8p	442	24	by	by	IN
cord-012418-6ralcn8p	442	25	interacting	interact	VBG
cord-012418-6ralcn8p	442	26	with	with	IN
cord-012418-6ralcn8p	442	27	the	the	DT
cord-012418-6ralcn8p	442	28	nuclear	nuclear	JJ
cord-012418-6ralcn8p	442	29	transport	transport	NN
cord-012418-6ralcn8p	442	30	proteins	protein	NNS
cord-012418-6ralcn8p	442	31	KPNA3	KPNA3	NNP
cord-012418-6ralcn8p	442	32	and	and	CC
cord-012418-6ralcn8p	442	33	KPNA4	KPNA4	NNP
cord-012418-6ralcn8p	442	34	[	[	-LRB-
cord-012418-6ralcn8p	442	35	213	213	CD
cord-012418-6ralcn8p	442	36	]	]	-RRB-
cord-012418-6ralcn8p	442	37	.	.	.
cord-012418-6ralcn8p	443	1	This	this	DT
cord-012418-6ralcn8p	443	2	interaction	interaction	NN
cord-012418-6ralcn8p	443	3	competitively	competitively	RB
cord-012418-6ralcn8p	443	4	blocks	block	VBZ
cord-012418-6ralcn8p	443	5	the	the	DT
cord-012418-6ralcn8p	443	6	interaction	interaction	NN
cord-012418-6ralcn8p	443	7	with	with	IN
cord-012418-6ralcn8p	443	8	the	the	DT
cord-012418-6ralcn8p	443	9	native	native	JJ
cord-012418-6ralcn8p	443	10	cargo	cargo	NN
cord-012418-6ralcn8p	443	11	of	of	IN
cord-012418-6ralcn8p	443	12	the	the	DT
cord-012418-6ralcn8p	443	13	importins	importin	NNS
cord-012418-6ralcn8p	443	14	,	,	,
cord-012418-6ralcn8p	443	15	including	include	VBG
cord-012418-6ralcn8p	443	16	the	the	DT
cord-012418-6ralcn8p	443	17	transcription	transcription	NN
cord-012418-6ralcn8p	443	18	factors	factor	NNS
cord-012418-6ralcn8p	443	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	443	20	and	and	CC
cord-012418-6ralcn8p	443	21	p65	p65	ADD
cord-012418-6ralcn8p	443	22	.	.	.
cord-012418-6ralcn8p	444	1	Similarly	similarly	RB
cord-012418-6ralcn8p	444	2	,	,	,
cord-012418-6ralcn8p	444	3	the	the	DT
cord-012418-6ralcn8p	444	4	NS3/4A	ns3/4a	JJ
cord-012418-6ralcn8p	444	5	protease	protease	NN
cord-012418-6ralcn8p	444	6	of	of	IN
cord-012418-6ralcn8p	444	7	the	the	DT
cord-012418-6ralcn8p	444	8	related	relate	VBN
cord-012418-6ralcn8p	444	9	hepatitis	hepatitis	NN
cord-012418-6ralcn8p	444	10	C	c	NN
cord-012418-6ralcn8p	444	11	virus	virus	NN
cord-012418-6ralcn8p	444	12	(	(	-LRB-
cord-012418-6ralcn8p	444	13	HCV	HCV	NNP
cord-012418-6ralcn8p	444	14	)	)	-RRB-
cord-012418-6ralcn8p	444	15	triggers	trigger	VBZ
cord-012418-6ralcn8p	444	16	cleavage	cleavage	NN
cord-012418-6ralcn8p	444	17	of	of	IN
cord-012418-6ralcn8p	444	18	importin	importin	FW
cord-012418-6ralcn8p	444	19	β1	β1	NNP
cord-012418-6ralcn8p	444	20	(	(	-LRB-
cord-012418-6ralcn8p	444	21	IPOB	IPOB	NNP
cord-012418-6ralcn8p	444	22	,	,	,
cord-012418-6ralcn8p	444	23	also	also	RB
cord-012418-6ralcn8p	444	24	KPNB1	KPNB1	NNP
cord-012418-6ralcn8p	444	25	)	)	-RRB-
cord-012418-6ralcn8p	444	26	and	and	CC
cord-012418-6ralcn8p	444	27	in	in	IN
cord-012418-6ralcn8p	444	28	this	this	DT
cord-012418-6ralcn8p	444	29	way	way	NN
cord-012418-6ralcn8p	444	30	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	444	31	the	the	DT
cord-012418-6ralcn8p	444	32	transport	transport	NN
cord-012418-6ralcn8p	444	33	of	of	IN
cord-012418-6ralcn8p	444	34	IRF3	IRF3	NNP
cord-012418-6ralcn8p	444	35	into	into	IN
cord-012418-6ralcn8p	444	36	the	the	DT
cord-012418-6ralcn8p	444	37	nucleus	nucleus	NN
cord-012418-6ralcn8p	444	38	to	to	TO
cord-012418-6ralcn8p	444	39	interrupt	interrupt	VB
cord-012418-6ralcn8p	444	40	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	444	41	production	production	VB
cord-012418-6ralcn8p	444	42	[	[	-LRB-
cord-012418-6ralcn8p	444	43	214	214	CD
cord-012418-6ralcn8p	444	44	]	]	-RRB-
cord-012418-6ralcn8p	444	45	.	.	.
cord-012418-6ralcn8p	445	1	Once	once	IN
cord-012418-6ralcn8p	445	2	IRF3	IRF3	NNP
cord-012418-6ralcn8p	445	3	has	have	VBZ
cord-012418-6ralcn8p	445	4	reached	reach	VBN
cord-012418-6ralcn8p	445	5	the	the	DT
cord-012418-6ralcn8p	445	6	nucleus	nucleus	NN
cord-012418-6ralcn8p	445	7	,	,	,
cord-012418-6ralcn8p	445	8	it	-PRON-	PRP
cord-012418-6ralcn8p	445	9	interacts	interact	VBZ
cord-012418-6ralcn8p	445	10	with	with	IN
cord-012418-6ralcn8p	445	11	the	the	DT
cord-012418-6ralcn8p	445	12	coactivator	coactivator	NN
cord-012418-6ralcn8p	445	13	CBP	CBP	NNP
cord-012418-6ralcn8p	445	14	/	/	SYM
cord-012418-6ralcn8p	445	15	p300	p300	NNP
cord-012418-6ralcn8p	445	16	to	to	TO
cord-012418-6ralcn8p	445	17	obtain	obtain	VB
cord-012418-6ralcn8p	445	18	the	the	DT
cord-012418-6ralcn8p	445	19	potential	potential	NN
cord-012418-6ralcn8p	445	20	to	to	TO
cord-012418-6ralcn8p	445	21	induce	induce	VB
cord-012418-6ralcn8p	445	22	transcription	transcription	NN
cord-012418-6ralcn8p	445	23	.	.	.
cord-012418-6ralcn8p	446	1	When	when	WRB
cord-012418-6ralcn8p	446	2	studies	study	NNS
cord-012418-6ralcn8p	446	3	concerned	concern	VBN
cord-012418-6ralcn8p	446	4	with	with	IN
cord-012418-6ralcn8p	446	5	the	the	DT
cord-012418-6ralcn8p	446	6	molecular	molecular	JJ
cord-012418-6ralcn8p	446	7	requirements	requirement	NNS
cord-012418-6ralcn8p	446	8	for	for	IN
cord-012418-6ralcn8p	446	9	the	the	DT
cord-012418-6ralcn8p	446	10	induction	induction	NN
cord-012418-6ralcn8p	446	11	of	of	IN
cord-012418-6ralcn8p	446	12	type	type	NN
cord-012418-6ralcn8p	446	13	I	-PRON-	PRP
cord-012418-6ralcn8p	446	14	IFNs	ifn	NNS
cord-012418-6ralcn8p	446	15	were	be	VBD
cord-012418-6ralcn8p	446	16	still	still	RB
cord-012418-6ralcn8p	446	17	on	on	IN
cord-012418-6ralcn8p	446	18	their	-PRON-	PRP$
cord-012418-6ralcn8p	446	19	way	way	NN
cord-012418-6ralcn8p	446	20	,	,	,
cord-012418-6ralcn8p	446	21	the	the	DT
cord-012418-6ralcn8p	446	22	critical	critical	JJ
cord-012418-6ralcn8p	446	23	role	role	NN
cord-012418-6ralcn8p	446	24	of	of	IN
cord-012418-6ralcn8p	446	25	the	the	DT
cord-012418-6ralcn8p	446	26	coactivators	coactivator	NNS
cord-012418-6ralcn8p	446	27	for	for	IN
cord-012418-6ralcn8p	446	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	446	29	activity	activity	NN
cord-012418-6ralcn8p	446	30	was	be	VBD
cord-012418-6ralcn8p	446	31	underlined	underline	VBN
cord-012418-6ralcn8p	446	32	by	by	IN
cord-012418-6ralcn8p	446	33	the	the	DT
cord-012418-6ralcn8p	446	34	observation	observation	NN
cord-012418-6ralcn8p	446	35	that	that	IN
cord-012418-6ralcn8p	446	36	the	the	DT
cord-012418-6ralcn8p	446	37	antagonistic	antagonistic	JJ
cord-012418-6ralcn8p	446	38	activity	activity	NN
cord-012418-6ralcn8p	446	39	of	of	IN
cord-012418-6ralcn8p	446	40	adenovirus	adenovirus	NN
cord-012418-6ralcn8p	446	41	(	(	-LRB-
cord-012418-6ralcn8p	446	42	AdV	AdV	NNP
cord-012418-6ralcn8p	446	43	)	)	-RRB-
cord-012418-6ralcn8p	446	44	protein	protein	NN
cord-012418-6ralcn8p	446	45	E1A	e1a	NN
cord-012418-6ralcn8p	446	46	on	on	IN
cord-012418-6ralcn8p	446	47	IRF3-mediated	irf3-mediated	JJ
cord-012418-6ralcn8p	446	48	stimulation	stimulation	NN
cord-012418-6ralcn8p	446	49	was	be	VBD
cord-012418-6ralcn8p	446	50	dependent	dependent	JJ
cord-012418-6ralcn8p	446	51	on	on	IN
cord-012418-6ralcn8p	446	52	the	the	DT
cord-012418-6ralcn8p	446	53	interaction	interaction	NN
cord-012418-6ralcn8p	446	54	of	of	IN
cord-012418-6ralcn8p	446	55	E1A	e1a	NN
cord-012418-6ralcn8p	446	56	with	with	IN
cord-012418-6ralcn8p	446	57	CBP	CBP	NNP
cord-012418-6ralcn8p	446	58	[	[	-LRB-
cord-012418-6ralcn8p	446	59	176	176	CD
cord-012418-6ralcn8p	446	60	]	]	-RRB-
cord-012418-6ralcn8p	446	61	.	.	.
cord-012418-6ralcn8p	447	1	The	the	DT
cord-012418-6ralcn8p	447	2	inhibition	inhibition	NN
cord-012418-6ralcn8p	447	3	of	of	IN
cord-012418-6ralcn8p	447	4	IFNB1	ifnb1	DT
cord-012418-6ralcn8p	447	5	transcription	transcription	NN
cord-012418-6ralcn8p	447	6	by	by	IN
cord-012418-6ralcn8p	447	7	E1A	E1A	NNP
cord-012418-6ralcn8p	447	8	could	could	MD
cord-012418-6ralcn8p	447	9	be	be	VB
cord-012418-6ralcn8p	447	10	competed	compete	VBN
cord-012418-6ralcn8p	447	11	with	with	IN
cord-012418-6ralcn8p	447	12	by	by	IN
cord-012418-6ralcn8p	447	13	overexpression	overexpression	NN
cord-012418-6ralcn8p	447	14	of	of	IN
cord-012418-6ralcn8p	447	15	CBP	CBP	NNP
cord-012418-6ralcn8p	447	16	/	/	SYM
cord-012418-6ralcn8p	447	17	p300	p300	NNP
cord-012418-6ralcn8p	447	18	but	but	CC
cord-012418-6ralcn8p	447	19	was	be	VBD
cord-012418-6ralcn8p	447	20	not	not	RB
cord-012418-6ralcn8p	447	21	observed	observe	VBN
cord-012418-6ralcn8p	447	22	for	for	IN
cord-012418-6ralcn8p	447	23	a	a	DT
cord-012418-6ralcn8p	447	24	mutant	mutant	NN
cord-012418-6ralcn8p	447	25	of	of	IN
cord-012418-6ralcn8p	447	26	E1A	e1a	NN
cord-012418-6ralcn8p	447	27	that	that	WDT
cord-012418-6ralcn8p	447	28	was	be	VBD
cord-012418-6ralcn8p	447	29	defective	defective	JJ
cord-012418-6ralcn8p	447	30	in	in	IN
cord-012418-6ralcn8p	447	31	p300-binding	p300-binding	NN
cord-012418-6ralcn8p	447	32	.	.	.
cord-012418-6ralcn8p	448	1	Mechanistically	Mechanistically	NNP
cord-012418-6ralcn8p	448	2	,	,	,
cord-012418-6ralcn8p	448	3	these	these	DT
cord-012418-6ralcn8p	448	4	observations	observation	NNS
cord-012418-6ralcn8p	448	5	implied	imply	VBD
cord-012418-6ralcn8p	448	6	that	that	IN
cord-012418-6ralcn8p	448	7	E1A	e1a	NN
cord-012418-6ralcn8p	448	8	competed	compete	VBD
cord-012418-6ralcn8p	448	9	with	with	IN
cord-012418-6ralcn8p	448	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	448	11	for	for	IN
cord-012418-6ralcn8p	448	12	binding	bind	VBG
cord-012418-6ralcn8p	448	13	to	to	IN
cord-012418-6ralcn8p	448	14	the	the	DT
cord-012418-6ralcn8p	448	15	essential	essential	JJ
cord-012418-6ralcn8p	448	16	coactivator	coactivator	NN
cord-012418-6ralcn8p	448	17	[	[	-LRB-
cord-012418-6ralcn8p	448	18	176	176	CD
cord-012418-6ralcn8p	448	19	]	]	-RRB-
cord-012418-6ralcn8p	448	20	.	.	.
cord-012418-6ralcn8p	449	1	To	to	TO
cord-012418-6ralcn8p	449	2	interfere	interfere	VB
cord-012418-6ralcn8p	449	3	with	with	IN
cord-012418-6ralcn8p	449	4	the	the	DT
cord-012418-6ralcn8p	449	5	productive	productive	JJ
cord-012418-6ralcn8p	449	6	association	association	NN
cord-012418-6ralcn8p	449	7	of	of	IN
cord-012418-6ralcn8p	449	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	449	9	and	and	CC
cord-012418-6ralcn8p	449	10	CBP	CBP	NNP
cord-012418-6ralcn8p	449	11	/	/	SYM
cord-012418-6ralcn8p	449	12	p300	p300	NNP
cord-012418-6ralcn8p	449	13	,	,	,
cord-012418-6ralcn8p	449	14	the	the	DT
cord-012418-6ralcn8p	449	15	viral	viral	JJ
cord-012418-6ralcn8p	449	16	antagonists	antagonist	NNS
cord-012418-6ralcn8p	449	17	NS1	NS1	NNS
cord-012418-6ralcn8p	449	18	of	of	IN
cord-012418-6ralcn8p	449	19	human	human	JJ
cord-012418-6ralcn8p	449	20	respiratory	respiratory	JJ
cord-012418-6ralcn8p	449	21	syncytial	syncytial	JJ
cord-012418-6ralcn8p	449	22	virus	virus	NN
cord-012418-6ralcn8p	449	23	(	(	-LRB-
cord-012418-6ralcn8p	449	24	RSV	RSV	NNP
cord-012418-6ralcn8p	449	25	)	)	-RRB-
cord-012418-6ralcn8p	449	26	[	[	-LRB-
cord-012418-6ralcn8p	449	27	215	215	CD
cord-012418-6ralcn8p	449	28	]	]	-RRB-
cord-012418-6ralcn8p	449	29	,	,	,
cord-012418-6ralcn8p	449	30	E6	e6	NN
cord-012418-6ralcn8p	449	31	protein	protein	NN
cord-012418-6ralcn8p	449	32	of	of	IN
cord-012418-6ralcn8p	449	33	human	human	JJ
cord-012418-6ralcn8p	449	34	papillomavirus	papillomavirus	NN
cord-012418-6ralcn8p	449	35	16	16	CD
cord-012418-6ralcn8p	449	36	(	(	-LRB-
cord-012418-6ralcn8p	449	37	HPV-16	HPV-16	NNP
cord-012418-6ralcn8p	449	38	)	)	-RRB-
cord-012418-6ralcn8p	450	1	[	[	-LRB-
cord-012418-6ralcn8p	450	2	175	175	CD
cord-012418-6ralcn8p	450	3	,	,	,
cord-012418-6ralcn8p	450	4	216	216	CD
cord-012418-6ralcn8p	450	5	]	]	-RRB-
cord-012418-6ralcn8p	450	6	and	and	CC
cord-012418-6ralcn8p	450	7	the	the	DT
cord-012418-6ralcn8p	450	8	tegument	tegument	NN
cord-012418-6ralcn8p	450	9	protein	protein	NN
cord-012418-6ralcn8p	450	10	VP16	VP16	NNP
cord-012418-6ralcn8p	450	11	of	of	IN
cord-012418-6ralcn8p	450	12	HSV-1	HSV-1	NNP
cord-012418-6ralcn8p	450	13	target	target	VBP
cord-012418-6ralcn8p	450	14	both	both	DT
cord-012418-6ralcn8p	450	15	proteins	protein	NNS
cord-012418-6ralcn8p	450	16	simultaneously	simultaneously	RB
cord-012418-6ralcn8p	450	17	[	[	-LRB-
cord-012418-6ralcn8p	450	18	217	217	CD
cord-012418-6ralcn8p	450	19	]	]	-RRB-
cord-012418-6ralcn8p	450	20	.	.	.
cord-012418-6ralcn8p	451	1	In	in	IN
cord-012418-6ralcn8p	451	2	contrast	contrast	NN
cord-012418-6ralcn8p	451	3	,	,	,
cord-012418-6ralcn8p	451	4	the	the	DT
cord-012418-6ralcn8p	451	5	kinase	kinase	NN
cord-012418-6ralcn8p	451	6	ORF36	orf36	NN
cord-012418-6ralcn8p	451	7	of	of	IN
cord-012418-6ralcn8p	451	8	murine	murine	JJ
cord-012418-6ralcn8p	451	9	gammaherpesvirus	gammaherpesvirus	NNP
cord-012418-6ralcn8p	451	10	68	68	CD
cord-012418-6ralcn8p	451	11	(	(	-LRB-
cord-012418-6ralcn8p	451	12	MHV68	MHV68	NNP
cord-012418-6ralcn8p	451	13	)	)	-RRB-
cord-012418-6ralcn8p	451	14	specifically	specifically	RB
cord-012418-6ralcn8p	451	15	interacts	interact	VBZ
cord-012418-6ralcn8p	451	16	only	only	RB
cord-012418-6ralcn8p	451	17	with	with	IN
cord-012418-6ralcn8p	451	18	activated	activate	VBN
cord-012418-6ralcn8p	451	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	451	20	in	in	IN
cord-012418-6ralcn8p	451	21	the	the	DT
cord-012418-6ralcn8p	451	22	nucleus	nucleus	NN
cord-012418-6ralcn8p	451	23	to	to	TO
cord-012418-6ralcn8p	451	24	interfere	interfere	VB
cord-012418-6ralcn8p	451	25	with	with	IN
cord-012418-6ralcn8p	451	26	the	the	DT
cord-012418-6ralcn8p	451	27	association	association	NNP
cord-012418-6ralcn8p	451	28	of	of	IN
cord-012418-6ralcn8p	451	29	coactivators	coactivators	NNP
cord-012418-6ralcn8p	451	30	[	[	-LRB-
cord-012418-6ralcn8p	451	31	218	218	CD
cord-012418-6ralcn8p	451	32	]	]	-RRB-
cord-012418-6ralcn8p	451	33	.	.	.
cord-012418-6ralcn8p	452	1	This	this	DT
cord-012418-6ralcn8p	452	2	protein	protein	NN
cord-012418-6ralcn8p	452	3	is	be	VBZ
cord-012418-6ralcn8p	452	4	highly	highly	RB
cord-012418-6ralcn8p	452	5	conserved	conserve	VBN
cord-012418-6ralcn8p	452	6	,	,	,
cord-012418-6ralcn8p	452	7	implying	imply	VBG
cord-012418-6ralcn8p	452	8	similar	similar	JJ
cord-012418-6ralcn8p	452	9	functions	function	NNS
cord-012418-6ralcn8p	452	10	of	of	IN
cord-012418-6ralcn8p	452	11	its	-PRON-	PRP$
cord-012418-6ralcn8p	452	12	homologue	homologue	NN
cord-012418-6ralcn8p	452	13	in	in	IN
cord-012418-6ralcn8p	452	14	Kaposi	Kaposi	NNP
cord-012418-6ralcn8p	452	15	's	's	POS
cord-012418-6ralcn8p	452	16	sarcoma	sarcoma	NN
cord-012418-6ralcn8p	452	17	-	-	HYPH
cord-012418-6ralcn8p	452	18	associated	associate	VBN
cord-012418-6ralcn8p	452	19	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	452	20	(	(	-LRB-
cord-012418-6ralcn8p	452	21	KSHV	KSHV	NNP
cord-012418-6ralcn8p	452	22	)	)	-RRB-
cord-012418-6ralcn8p	452	23	,	,	,
cord-012418-6ralcn8p	452	24	though	though	IN
cord-012418-6ralcn8p	452	25	the	the	DT
cord-012418-6ralcn8p	452	26	conserved	conserve	VBN
cord-012418-6ralcn8p	452	27	kinase	kinase	NN
cord-012418-6ralcn8p	452	28	activity	activity	NN
cord-012418-6ralcn8p	452	29	is	be	VBZ
cord-012418-6ralcn8p	452	30	not	not	RB
cord-012418-6ralcn8p	452	31	required	require	VBN
cord-012418-6ralcn8p	452	32	for	for	IN
cord-012418-6ralcn8p	452	33	this	this	DT
cord-012418-6ralcn8p	452	34	function	function	NN
cord-012418-6ralcn8p	452	35	[	[	-LRB-
cord-012418-6ralcn8p	452	36	218	218	CD
cord-012418-6ralcn8p	452	37	]	]	-RRB-
cord-012418-6ralcn8p	452	38	.	.	.
cord-012418-6ralcn8p	453	1	A	a	DT
cord-012418-6ralcn8p	453	2	striking	striking	JJ
cord-012418-6ralcn8p	453	3	example	example	NN
cord-012418-6ralcn8p	453	4	for	for	IN
cord-012418-6ralcn8p	453	5	the	the	DT
cord-012418-6ralcn8p	453	6	exploitation	exploitation	NN
cord-012418-6ralcn8p	453	7	of	of	IN
cord-012418-6ralcn8p	453	8	structural	structural	JJ
cord-012418-6ralcn8p	453	9	homology	homology	NN
cord-012418-6ralcn8p	453	10	by	by	IN
cord-012418-6ralcn8p	453	11	viruses	virus	NNS
cord-012418-6ralcn8p	453	12	are	be	VBP
cord-012418-6ralcn8p	453	13	the	the	DT
cord-012418-6ralcn8p	453	14	viral	viral	JJ
cord-012418-6ralcn8p	453	15	homologues	homologue	NNS
cord-012418-6ralcn8p	453	16	of	of	IN
cord-012418-6ralcn8p	453	17	IRFs	IRFs	NNP
cord-012418-6ralcn8p	453	18	,	,	,
cord-012418-6ralcn8p	453	19	termed	term	VBN
cord-012418-6ralcn8p	453	20	vIRFs	virfs	NN
cord-012418-6ralcn8p	453	21	,	,	,
cord-012418-6ralcn8p	453	22	which	which	WDT
cord-012418-6ralcn8p	453	23	are	be	VBP
cord-012418-6ralcn8p	453	24	encoded	encode	VBN
cord-012418-6ralcn8p	453	25	by	by	IN
cord-012418-6ralcn8p	453	26	some	some	DT
cord-012418-6ralcn8p	453	27	herpesviruses	herpesviruse	NNS
cord-012418-6ralcn8p	453	28	to	to	TO
cord-012418-6ralcn8p	453	29	interfere	interfere	VB
cord-012418-6ralcn8p	453	30	with	with	IN
cord-012418-6ralcn8p	453	31	the	the	DT
cord-012418-6ralcn8p	453	32	activity	activity	NN
cord-012418-6ralcn8p	453	33	of	of	IN
cord-012418-6ralcn8p	453	34	host	host	NN
cord-012418-6ralcn8p	453	35	IRFs	irfs	NN
cord-012418-6ralcn8p	453	36	.	.	.
cord-012418-6ralcn8p	454	1	For	for	IN
cord-012418-6ralcn8p	454	2	details	detail	NNS
cord-012418-6ralcn8p	454	3	on	on	IN
cord-012418-6ralcn8p	454	4	the	the	DT
cord-012418-6ralcn8p	454	5	interplay	interplay	NN
cord-012418-6ralcn8p	454	6	of	of	IN
cord-012418-6ralcn8p	454	7	vIRFs	virfs	NN
cord-012418-6ralcn8p	454	8	and	and	CC
cord-012418-6ralcn8p	454	9	host	host	VB
cord-012418-6ralcn8p	454	10	IRFs	irfs	NN
cord-012418-6ralcn8p	454	11	and	and	CC
cord-012418-6ralcn8p	454	12	their	-PRON-	PRP$
cord-012418-6ralcn8p	454	13	implications	implication	NNS
cord-012418-6ralcn8p	454	14	for	for	IN
cord-012418-6ralcn8p	454	15	the	the	DT
cord-012418-6ralcn8p	454	16	viral	viral	JJ
cord-012418-6ralcn8p	454	17	replication	replication	NN
cord-012418-6ralcn8p	454	18	style	style	NN
cord-012418-6ralcn8p	454	19	,	,	,
cord-012418-6ralcn8p	454	20	please	please	UH
cord-012418-6ralcn8p	454	21	refer	refer	VB
cord-012418-6ralcn8p	454	22	to	to	IN
cord-012418-6ralcn8p	454	23	the	the	DT
cord-012418-6ralcn8p	454	24	recent	recent	JJ
cord-012418-6ralcn8p	454	25	review	review	NN
cord-012418-6ralcn8p	454	26	by	by	IN
cord-012418-6ralcn8p	454	27	Myoung	Myoung	NNP
cord-012418-6ralcn8p	454	28	and	and	CC
cord-012418-6ralcn8p	454	29	colleagues	colleague	NNS
cord-012418-6ralcn8p	454	30	[	[	-LRB-
cord-012418-6ralcn8p	454	31	219	219	CD
cord-012418-6ralcn8p	454	32	]	]	-RRB-
cord-012418-6ralcn8p	454	33	.	.	.
cord-012418-6ralcn8p	455	1	Shortly	shortly	RB
cord-012418-6ralcn8p	455	2	,	,	,
cord-012418-6ralcn8p	455	3	vIRF1	vIRF1	NNP
cord-012418-6ralcn8p	455	4	of	of	IN
cord-012418-6ralcn8p	455	5	KSHV	KSHV	NNP
cord-012418-6ralcn8p	455	6	binds	bind	VBZ
cord-012418-6ralcn8p	455	7	to	to	IN
cord-012418-6ralcn8p	455	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	455	9	as	as	RB
cord-012418-6ralcn8p	455	10	well	well	RB
cord-012418-6ralcn8p	455	11	as	as	IN
cord-012418-6ralcn8p	455	12	p300	p300	NNP
cord-012418-6ralcn8p	455	13	and	and	CC
cord-012418-6ralcn8p	455	14	in	in	IN
cord-012418-6ralcn8p	455	15	this	this	DT
cord-012418-6ralcn8p	455	16	way	way	NN
cord-012418-6ralcn8p	455	17	obstructs	obstruct	VBZ
cord-012418-6ralcn8p	455	18	formation	formation	NN
cord-012418-6ralcn8p	455	19	of	of	IN
cord-012418-6ralcn8p	455	20	the	the	DT
cord-012418-6ralcn8p	455	21	active	active	JJ
cord-012418-6ralcn8p	455	22	holocomplex	holocomplex	NN
cord-012418-6ralcn8p	455	23	of	of	IN
cord-012418-6ralcn8p	455	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	455	25	and	and	CC
cord-012418-6ralcn8p	455	26	CBP	CBP	NNP
cord-012418-6ralcn8p	455	27	/	/	SYM
cord-012418-6ralcn8p	455	28	p300	p300	NN
cord-012418-6ralcn8p	455	29	[	[	-LRB-
cord-012418-6ralcn8p	455	30	220	220	CD
cord-012418-6ralcn8p	455	31	]	]	-RRB-
cord-012418-6ralcn8p	455	32	[	[	-LRB-
cord-012418-6ralcn8p	455	33	221	221	CD
cord-012418-6ralcn8p	455	34	]	]	-RRB-
cord-012418-6ralcn8p	455	35	[	[	-LRB-
cord-012418-6ralcn8p	455	36	222	222	CD
cord-012418-6ralcn8p	455	37	]	]	-RRB-
cord-012418-6ralcn8p	455	38	.	.	.
cord-012418-6ralcn8p	456	1	Additionally	additionally	RB
cord-012418-6ralcn8p	456	2	,	,	,
cord-012418-6ralcn8p	456	3	KSHV	KSHV	NNP
cord-012418-6ralcn8p	456	4	deploys	deploy	VBZ
cord-012418-6ralcn8p	456	5	vIRF2	virf2	VBP
cord-012418-6ralcn8p	456	6	to	to	TO
cord-012418-6ralcn8p	456	7	target	target	VB
cord-012418-6ralcn8p	456	8	IRF3-driven	IRF3-driven	NNP
cord-012418-6ralcn8p	456	9	gene	gene	NN
cord-012418-6ralcn8p	456	10	expression	expression	NN
cord-012418-6ralcn8p	456	11	[	[	-LRB-
cord-012418-6ralcn8p	456	12	223	223	CD
cord-012418-6ralcn8p	456	13	]	]	-RRB-
cord-012418-6ralcn8p	456	14	.	.	.
cord-012418-6ralcn8p	457	1	Similar	similar	JJ
cord-012418-6ralcn8p	457	2	to	to	IN
cord-012418-6ralcn8p	457	3	vIRF1	vIRF1	NNP
cord-012418-6ralcn8p	457	4	,	,	,
cord-012418-6ralcn8p	457	5	also	also	RB
cord-012418-6ralcn8p	457	6	the	the	DT
cord-012418-6ralcn8p	457	7	virion	virion	NN
cord-012418-6ralcn8p	457	8	-	-	HYPH
cord-012418-6ralcn8p	457	9	associated	associate	VBN
cord-012418-6ralcn8p	457	10	vIRF	virf	NN
cord-012418-6ralcn8p	457	11	R6	R6	NNP
cord-012418-6ralcn8p	457	12	of	of	IN
cord-012418-6ralcn8p	457	13	the	the	DT
cord-012418-6ralcn8p	457	14	gammaherpesvirus	gammaherpesvirus	NNP
cord-012418-6ralcn8p	457	15	rhesus	rhesus	NNP
cord-012418-6ralcn8p	457	16	macaque	macaque	NNP
cord-012418-6ralcn8p	457	17	rhadinovirus	rhadinovirus	NNP
cord-012418-6ralcn8p	457	18	(	(	-LRB-
cord-012418-6ralcn8p	457	19	RRV	RRV	NNP
cord-012418-6ralcn8p	457	20	)	)	-RRB-
cord-012418-6ralcn8p	457	21	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	457	22	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	457	23	expression	expression	NN
cord-012418-6ralcn8p	457	24	by	by	IN
cord-012418-6ralcn8p	457	25	targeting	target	VBG
cord-012418-6ralcn8p	457	26	CBP	CBP	NNP
cord-012418-6ralcn8p	457	27	and	and	CC
cord-012418-6ralcn8p	457	28	competing	compete	VBG
cord-012418-6ralcn8p	457	29	with	with	IN
cord-012418-6ralcn8p	457	30	phosphorylated	phosphorylated	JJ
cord-012418-6ralcn8p	457	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	457	32	for	for	IN
cord-012418-6ralcn8p	457	33	binding	bind	VBG
cord-012418-6ralcn8p	457	34	[	[	-LRB-
cord-012418-6ralcn8p	457	35	224	224	CD
cord-012418-6ralcn8p	457	36	]	]	-RRB-
cord-012418-6ralcn8p	457	37	.	.	.
cord-012418-6ralcn8p	458	1	As	as	IN
cord-012418-6ralcn8p	458	2	tegument	tegument	NN
cord-012418-6ralcn8p	458	3	proteins	protein	NNS
cord-012418-6ralcn8p	458	4	,	,	,
cord-012418-6ralcn8p	458	5	RRV	RRV	NNP
cord-012418-6ralcn8p	458	6	R6	R6	NNP
cord-012418-6ralcn8p	458	7	and	and	CC
cord-012418-6ralcn8p	458	8	also	also	RB
cord-012418-6ralcn8p	458	9	HSV-1	HSV-1	NNP
cord-012418-6ralcn8p	458	10	VP16	VP16	NNP
cord-012418-6ralcn8p	458	11	are	be	VBP
cord-012418-6ralcn8p	458	12	released	release	VBN
cord-012418-6ralcn8p	458	13	into	into	IN
cord-012418-6ralcn8p	458	14	the	the	DT
cord-012418-6ralcn8p	458	15	host	host	NN
cord-012418-6ralcn8p	458	16	cell	cell	NN
cord-012418-6ralcn8p	458	17	alongside	alongside	IN
cord-012418-6ralcn8p	458	18	the	the	DT
cord-012418-6ralcn8p	458	19	entering	enter	VBG
cord-012418-6ralcn8p	458	20	virus	virus	NN
cord-012418-6ralcn8p	458	21	and	and	CC
cord-012418-6ralcn8p	458	22	can	can	MD
cord-012418-6ralcn8p	458	23	directly	directly	RB
cord-012418-6ralcn8p	458	24	take	take	VB
cord-012418-6ralcn8p	458	25	action	action	NN
cord-012418-6ralcn8p	458	26	to	to	TO
cord-012418-6ralcn8p	458	27	interfere	interfere	VB
cord-012418-6ralcn8p	458	28	with	with	IN
cord-012418-6ralcn8p	458	29	IRF3	IRF3	NNP
cord-012418-6ralcn8p	458	30	activity	activity	NN
cord-012418-6ralcn8p	458	31	before	before	IN
cord-012418-6ralcn8p	458	32	a	a	DT
cord-012418-6ralcn8p	458	33	potent	potent	JJ
cord-012418-6ralcn8p	458	34	type	type	NN
cord-012418-6ralcn8p	459	1	I	-PRON-	PRP
cord-012418-6ralcn8p	459	2	IFN	IFN	NNP
cord-012418-6ralcn8p	459	3	response	response	NN
cord-012418-6ralcn8p	459	4	can	can	MD
cord-012418-6ralcn8p	459	5	be	be	VB
cord-012418-6ralcn8p	459	6	mounted	mount	VBN
cord-012418-6ralcn8p	459	7	.	.	.
cord-012418-6ralcn8p	460	1	Another	another	DT
cord-012418-6ralcn8p	460	2	strategy	strategy	NN
cord-012418-6ralcn8p	460	3	to	to	TO
cord-012418-6ralcn8p	460	4	hinder	hinder	VB
cord-012418-6ralcn8p	460	5	the	the	DT
cord-012418-6ralcn8p	460	6	participation	participation	NN
cord-012418-6ralcn8p	460	7	of	of	IN
cord-012418-6ralcn8p	460	8	the	the	DT
cord-012418-6ralcn8p	460	9	essential	essential	JJ
cord-012418-6ralcn8p	460	10	coactivator	coactivator	NN
cord-012418-6ralcn8p	460	11	CBP	CBP	NNP
cord-012418-6ralcn8p	460	12	is	be	VBZ
cord-012418-6ralcn8p	460	13	applied	apply	VBN
cord-012418-6ralcn8p	460	14	by	by	IN
cord-012418-6ralcn8p	460	15	several	several	JJ
cord-012418-6ralcn8p	460	16	RNA	RNA	NNP
cord-012418-6ralcn8p	460	17	viruses	virus	NNS
cord-012418-6ralcn8p	460	18	.	.	.
cord-012418-6ralcn8p	461	1	The	the	DT
cord-012418-6ralcn8p	461	2	non	non	JJ
cord-012418-6ralcn8p	461	3	-	-	JJ
cord-012418-6ralcn8p	461	4	structural	structural	JJ
cord-012418-6ralcn8p	461	5	protein	protein	NN
cord-012418-6ralcn8p	461	6	1	1	CD
cord-012418-6ralcn8p	461	7	(	(	-LRB-
cord-012418-6ralcn8p	461	8	nsp1	nsp1	NNS
cord-012418-6ralcn8p	461	9	)	)	-RRB-
cord-012418-6ralcn8p	461	10	subunits	subunit	NNS
cord-012418-6ralcn8p	461	11	nsp1α	nsp1α	NN
cord-012418-6ralcn8p	461	12	of	of	IN
cord-012418-6ralcn8p	461	13	murine	murine	JJ
cord-012418-6ralcn8p	461	14	lactate	lactate	NN
cord-012418-6ralcn8p	461	15	dehydrogenase	dehydrogenase	NN
cord-012418-6ralcn8p	461	16	-	-	HYPH
cord-012418-6ralcn8p	461	17	elevating	elevate	VBG
cord-012418-6ralcn8p	461	18	virus	virus	NN
cord-012418-6ralcn8p	461	19	(	(	-LRB-
cord-012418-6ralcn8p	461	20	LDV	LDV	NNP
cord-012418-6ralcn8p	461	21	)	)	-RRB-
cord-012418-6ralcn8p	461	22	[	[	-LRB-
cord-012418-6ralcn8p	461	23	225	225	CD
cord-012418-6ralcn8p	461	24	]	]	-RRB-
cord-012418-6ralcn8p	461	25	,	,	,
cord-012418-6ralcn8p	461	26	nsp1γ	nsp1γ	NNP
cord-012418-6ralcn8p	461	27	of	of	IN
cord-012418-6ralcn8p	461	28	simian	simian	JJ
cord-012418-6ralcn8p	461	29	haemorrhagic	haemorrhagic	JJ
cord-012418-6ralcn8p	461	30	fever	fever	NN
cord-012418-6ralcn8p	461	31	virus	virus	NN
cord-012418-6ralcn8p	461	32	(	(	-LRB-
cord-012418-6ralcn8p	461	33	SHFV	SHFV	NNP
cord-012418-6ralcn8p	461	34	)	)	-RRB-
cord-012418-6ralcn8p	462	1	[	[	-LRB-
cord-012418-6ralcn8p	462	2	225	225	CD
cord-012418-6ralcn8p	462	3	]	]	-RRB-
cord-012418-6ralcn8p	462	4	and	and	CC
cord-012418-6ralcn8p	462	5	nsp1α	nsp1α	NN
cord-012418-6ralcn8p	462	6	of	of	IN
cord-012418-6ralcn8p	462	7	porcine	porcine	JJ
cord-012418-6ralcn8p	462	8	reproductive	reproductive	JJ
cord-012418-6ralcn8p	462	9	and	and	CC
cord-012418-6ralcn8p	462	10	respiratory	respiratory	JJ
cord-012418-6ralcn8p	462	11	syndrome	syndrome	NN
cord-012418-6ralcn8p	462	12	virus	virus	NN
cord-012418-6ralcn8p	462	13	(	(	-LRB-
cord-012418-6ralcn8p	462	14	PRRSV	PRRSV	NNP
cord-012418-6ralcn8p	462	15	)	)	-RRB-
cord-012418-6ralcn8p	463	1	[	[	-LRB-
cord-012418-6ralcn8p	463	2	225	225	CD
cord-012418-6ralcn8p	463	3	]	]	-RRB-
cord-012418-6ralcn8p	463	4	[	[	-LRB-
cord-012418-6ralcn8p	463	5	226	226	CD
cord-012418-6ralcn8p	463	6	]	]	-RRB-
cord-012418-6ralcn8p	464	1	[	[	-LRB-
cord-012418-6ralcn8p	464	2	227	227	CD
cord-012418-6ralcn8p	464	3	]	]	-RRB-
cord-012418-6ralcn8p	464	4	of	of	IN
cord-012418-6ralcn8p	464	5	the	the	DT
cord-012418-6ralcn8p	464	6	Arteriviridae	Arteriviridae	NNP
cord-012418-6ralcn8p	464	7	family	family	NN
cord-012418-6ralcn8p	464	8	as	as	RB
cord-012418-6ralcn8p	464	9	well	well	RB
cord-012418-6ralcn8p	464	10	as	as	IN
cord-012418-6ralcn8p	464	11	nsp1	nsp1	NNS
cord-012418-6ralcn8p	464	12	of	of	IN
cord-012418-6ralcn8p	464	13	porcine	porcine	JJ
cord-012418-6ralcn8p	464	14	epidemic	epidemic	NN
cord-012418-6ralcn8p	464	15	diarrhoea	diarrhoea	NN
cord-012418-6ralcn8p	464	16	virus	virus	NN
cord-012418-6ralcn8p	464	17	(	(	-LRB-
cord-012418-6ralcn8p	464	18	PEDV	PEDV	NNP
cord-012418-6ralcn8p	464	19	)	)	-RRB-
cord-012418-6ralcn8p	465	1	[	[	-LRB-
cord-012418-6ralcn8p	465	2	228	228	CD
cord-012418-6ralcn8p	465	3	]	]	-RRB-
cord-012418-6ralcn8p	465	4	of	of	IN
cord-012418-6ralcn8p	465	5	the	the	DT
cord-012418-6ralcn8p	465	6	Coronaviridae	Coronaviridae	NNP
cord-012418-6ralcn8p	465	7	all	all	DT
cord-012418-6ralcn8p	465	8	suppress	suppress	VBP
cord-012418-6ralcn8p	465	9	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	465	10	expression	expression	NN
cord-012418-6ralcn8p	465	11	by	by	IN
cord-012418-6ralcn8p	465	12	specifically	specifically	RB
cord-012418-6ralcn8p	465	13	targeting	target	VBG
cord-012418-6ralcn8p	465	14	CBP	CBP	NNP
cord-012418-6ralcn8p	465	15	in	in	IN
cord-012418-6ralcn8p	465	16	the	the	DT
cord-012418-6ralcn8p	465	17	nucleus	nucleus	NN
cord-012418-6ralcn8p	465	18	and	and	CC
cord-012418-6ralcn8p	465	19	mediating	mediate	VBG
cord-012418-6ralcn8p	465	20	its	-PRON-	PRP$
cord-012418-6ralcn8p	465	21	proteasome	proteasome	NN
cord-012418-6ralcn8p	465	22	-	-	HYPH
cord-012418-6ralcn8p	465	23	dependent	dependent	JJ
cord-012418-6ralcn8p	465	24	degradation	degradation	NN
cord-012418-6ralcn8p	465	25	.	.	.
cord-012418-6ralcn8p	466	1	This	this	DT
cord-012418-6ralcn8p	466	2	approach	approach	NN
cord-012418-6ralcn8p	466	3	implies	imply	VBZ
cord-012418-6ralcn8p	466	4	that	that	IN
cord-012418-6ralcn8p	466	5	these	these	DT
cord-012418-6ralcn8p	466	6	viruses	virus	NNS
cord-012418-6ralcn8p	466	7	do	do	VBP
cord-012418-6ralcn8p	466	8	not	not	RB
cord-012418-6ralcn8p	466	9	require	require	VB
cord-012418-6ralcn8p	466	10	the	the	DT
cord-012418-6ralcn8p	466	11	activity	activity	NN
cord-012418-6ralcn8p	466	12	of	of	IN
cord-012418-6ralcn8p	466	13	CBP	CBP	NNP
cord-012418-6ralcn8p	466	14	to	to	TO
cord-012418-6ralcn8p	466	15	express	express	VB
cord-012418-6ralcn8p	466	16	their	-PRON-	PRP$
cord-012418-6ralcn8p	466	17	own	own	JJ
cord-012418-6ralcn8p	466	18	genome	genome	NN
cord-012418-6ralcn8p	466	19	,	,	,
cord-012418-6ralcn8p	466	20	which	which	WDT
cord-012418-6ralcn8p	466	21	is	be	VBZ
cord-012418-6ralcn8p	466	22	in	in	IN
cord-012418-6ralcn8p	466	23	line	line	NN
cord-012418-6ralcn8p	466	24	with	with	IN
cord-012418-6ralcn8p	466	25	their	-PRON-	PRP$
cord-012418-6ralcn8p	466	26	cytoplasmic	cytoplasmic	JJ
cord-012418-6ralcn8p	466	27	replication	replication	NN
cord-012418-6ralcn8p	466	28	.	.	.
cord-012418-6ralcn8p	467	1	The	the	DT
cord-012418-6ralcn8p	467	2	final	final	JJ
cord-012418-6ralcn8p	467	3	aim	aim	NN
cord-012418-6ralcn8p	467	4	of	of	IN
cord-012418-6ralcn8p	467	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	467	6	activation	activation	NN
cord-012418-6ralcn8p	467	7	is	be	VBZ
cord-012418-6ralcn8p	467	8	to	to	TO
cord-012418-6ralcn8p	467	9	enable	enable	VB
cord-012418-6ralcn8p	467	10	its	-PRON-	PRP$
cord-012418-6ralcn8p	467	11	binding	binding	NN
cord-012418-6ralcn8p	467	12	to	to	IN
cord-012418-6ralcn8p	467	13	recognition	recognition	NN
cord-012418-6ralcn8p	467	14	motifs	motif	NNS
cord-012418-6ralcn8p	467	15	within	within	IN
cord-012418-6ralcn8p	467	16	the	the	DT
cord-012418-6ralcn8p	467	17	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	467	18	enhancer	enhancer	NN
cord-012418-6ralcn8p	467	19	in	in	IN
cord-012418-6ralcn8p	467	20	order	order	NN
cord-012418-6ralcn8p	467	21	to	to	TO
cord-012418-6ralcn8p	467	22	allow	allow	VB
cord-012418-6ralcn8p	467	23	assembly	assembly	NN
cord-012418-6ralcn8p	467	24	of	of	IN
cord-012418-6ralcn8p	467	25	the	the	DT
cord-012418-6ralcn8p	467	26	IFNβ	IFNβ	NNP
cord-012418-6ralcn8p	467	27	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	467	28	and	and	CC
cord-012418-6ralcn8p	467	29	induce	induce	VB
cord-012418-6ralcn8p	467	30	transcription	transcription	NN
cord-012418-6ralcn8p	467	31	.	.	.
cord-012418-6ralcn8p	468	1	Again	again	RB
cord-012418-6ralcn8p	468	2	,	,	,
cord-012418-6ralcn8p	468	3	viral	viral	JJ
cord-012418-6ralcn8p	468	4	antagonists	antagonist	NNS
cord-012418-6ralcn8p	468	5	apply	apply	VBP
cord-012418-6ralcn8p	468	6	different	different	JJ
cord-012418-6ralcn8p	468	7	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	468	8	to	to	TO
cord-012418-6ralcn8p	468	9	interfere	interfere	VB
cord-012418-6ralcn8p	468	10	at	at	IN
cord-012418-6ralcn8p	468	11	this	this	DT
cord-012418-6ralcn8p	468	12	level	level	NN
cord-012418-6ralcn8p	468	13	.	.	.
cord-012418-6ralcn8p	469	1	The	the	DT
cord-012418-6ralcn8p	469	2	NP1	NP1	NNP
cord-012418-6ralcn8p	469	3	protein	protein	NN
cord-012418-6ralcn8p	469	4	of	of	IN
cord-012418-6ralcn8p	469	5	human	human	JJ
cord-012418-6ralcn8p	469	6	bocaparvovirus	bocaparvovirus	NNP
cord-012418-6ralcn8p	469	7	(	(	-LRB-
cord-012418-6ralcn8p	469	8	BoV	BoV	NNP
cord-012418-6ralcn8p	469	9	)	)	-RRB-
cord-012418-6ralcn8p	469	10	and	and	CC
cord-012418-6ralcn8p	469	11	US1	US1	NNP
cord-012418-6ralcn8p	469	12	of	of	IN
cord-012418-6ralcn8p	469	13	HSV-2	HSV-2	NNPS
cord-012418-6ralcn8p	469	14	prevent	prevent	VB
cord-012418-6ralcn8p	469	15	DNA	dna	NN
cord-012418-6ralcn8p	469	16	binding	binding	NN
cord-012418-6ralcn8p	469	17	by	by	IN
cord-012418-6ralcn8p	469	18	interaction	interaction	NN
cord-012418-6ralcn8p	469	19	with	with	IN
cord-012418-6ralcn8p	469	20	the	the	DT
cord-012418-6ralcn8p	469	21	DBD	DBD	NNP
cord-012418-6ralcn8p	469	22	of	of	IN
cord-012418-6ralcn8p	469	23	IRF3	IRF3	NNP
cord-012418-6ralcn8p	469	24	themselves	-PRON-	PRP
cord-012418-6ralcn8p	469	25	[	[	-LRB-
cord-012418-6ralcn8p	469	26	229	229	CD
cord-012418-6ralcn8p	469	27	,	,	,
cord-012418-6ralcn8p	469	28	230	230	CD
cord-012418-6ralcn8p	469	29	]	]	-RRB-
cord-012418-6ralcn8p	469	30	.	.	.
cord-012418-6ralcn8p	470	1	Further	further	RB
cord-012418-6ralcn8p	470	2	,	,	,
cord-012418-6ralcn8p	470	3	NSs	ns	NNS
cord-012418-6ralcn8p	470	4	of	of	IN
cord-012418-6ralcn8p	470	5	Sandfly	Sandfly	NNP
cord-012418-6ralcn8p	470	6	fever	fever	NN
cord-012418-6ralcn8p	470	7	Sicilian	sicilian	JJ
cord-012418-6ralcn8p	470	8	virus	virus	NN
cord-012418-6ralcn8p	470	9	(	(	-LRB-
cord-012418-6ralcn8p	470	10	SFSV	SFSV	NNP
cord-012418-6ralcn8p	470	11	)	)	-RRB-
cord-012418-6ralcn8p	470	12	of	of	IN
cord-012418-6ralcn8p	470	13	the	the	DT
cord-012418-6ralcn8p	470	14	Bunyaviridae	Bunyaviridae	NNP
cord-012418-6ralcn8p	470	15	family	family	NN
cord-012418-6ralcn8p	470	16	was	be	VBD
cord-012418-6ralcn8p	470	17	recently	recently	RB
cord-012418-6ralcn8p	470	18	reported	report	VBN
cord-012418-6ralcn8p	470	19	to	to	TO
cord-012418-6ralcn8p	470	20	apply	apply	VB
cord-012418-6ralcn8p	470	21	this	this	DT
cord-012418-6ralcn8p	470	22	strategy	strategy	NN
cord-012418-6ralcn8p	470	23	to	to	TO
cord-012418-6ralcn8p	470	24	prevent	prevent	VB
cord-012418-6ralcn8p	470	25	association	association	NN
cord-012418-6ralcn8p	470	26	of	of	IN
cord-012418-6ralcn8p	470	27	IRF3	IRF3	NNP
cord-012418-6ralcn8p	470	28	with	with	IN
cord-012418-6ralcn8p	470	29	the	the	DT
cord-012418-6ralcn8p	470	30	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	470	31	promoter	promoter	NN
cord-012418-6ralcn8p	470	32	[	[	-LRB-
cord-012418-6ralcn8p	470	33	231	231	CD
cord-012418-6ralcn8p	470	34	]	]	-RRB-
cord-012418-6ralcn8p	470	35	.	.	.
cord-012418-6ralcn8p	471	1	Wuerth	wuerth	NN
cord-012418-6ralcn8p	471	2	and	and	CC
cord-012418-6ralcn8p	471	3	colleagues	colleague	NNS
cord-012418-6ralcn8p	471	4	demonstrated	demonstrate	VBD
cord-012418-6ralcn8p	471	5	that	that	IN
cord-012418-6ralcn8p	471	6	NSs	NSs	NNP
cord-012418-6ralcn8p	471	7	specifically	specifically	RB
cord-012418-6ralcn8p	471	8	interacts	interact	VBZ
cord-012418-6ralcn8p	471	9	with	with	IN
cord-012418-6ralcn8p	471	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	471	11	via	via	IN
cord-012418-6ralcn8p	471	12	the	the	DT
cord-012418-6ralcn8p	471	13	DBD	DBD	NNP
cord-012418-6ralcn8p	471	14	and	and	CC
cord-012418-6ralcn8p	471	15	by	by	IN
cord-012418-6ralcn8p	471	16	this	this	DT
cord-012418-6ralcn8p	471	17	masking	masking	NN
cord-012418-6ralcn8p	471	18	competes	compete	VBZ
cord-012418-6ralcn8p	471	19	for	for	IN
cord-012418-6ralcn8p	471	20	DNA	dna	NN
cord-012418-6ralcn8p	471	21	binding	binding	NN
cord-012418-6ralcn8p	471	22	in	in	IN
cord-012418-6ralcn8p	471	23	a	a	DT
cord-012418-6ralcn8p	471	24	dose	dose	NN
cord-012418-6ralcn8p	471	25	-	-	HYPH
cord-012418-6ralcn8p	471	26	dependent	dependent	JJ
cord-012418-6ralcn8p	471	27	manner	manner	NN
cord-012418-6ralcn8p	471	28	.	.	.
cord-012418-6ralcn8p	472	1	Several	several	JJ
cord-012418-6ralcn8p	472	2	other	other	JJ
cord-012418-6ralcn8p	472	3	strategies	strategy	NNS
cord-012418-6ralcn8p	472	4	were	be	VBD
cord-012418-6ralcn8p	472	5	identified	identify	VBN
cord-012418-6ralcn8p	472	6	in	in	IN
cord-012418-6ralcn8p	472	7	the	the	DT
cord-012418-6ralcn8p	472	8	Herpesviridae	Herpesviridae	NNP
cord-012418-6ralcn8p	472	9	family	family	NN
cord-012418-6ralcn8p	472	10	:	:	:
cord-012418-6ralcn8p	473	1	(	(	-LRB-
cord-012418-6ralcn8p	473	2	i	i	NN
cord-012418-6ralcn8p	473	3	)	)	-RRB-
cord-012418-6ralcn8p	474	1	The	the	DT
cord-012418-6ralcn8p	474	2	nuclear	nuclear	JJ
cord-012418-6ralcn8p	474	3	share	share	NN
cord-012418-6ralcn8p	474	4	of	of	IN
cord-012418-6ralcn8p	474	5	the	the	DT
cord-012418-6ralcn8p	474	6	HSV-1	HSV-1	NNP
cord-012418-6ralcn8p	474	7	protein	protein	NN
cord-012418-6ralcn8p	474	8	ICP0	ICP0	NNP
cord-012418-6ralcn8p	474	9	relocalises	relocalises	NNP
cord-012418-6ralcn8p	474	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	474	11	and	and	CC
cord-012418-6ralcn8p	474	12	CBP	CBP	NNP
cord-012418-6ralcn8p	474	13	/	/	SYM
cord-012418-6ralcn8p	474	14	p300	p300	NNP
cord-012418-6ralcn8p	474	15	in	in	IN
cord-012418-6ralcn8p	474	16	the	the	DT
cord-012418-6ralcn8p	474	17	nucleus	nucleus	NN
cord-012418-6ralcn8p	474	18	to	to	IN
cord-012418-6ralcn8p	474	19	special	special	JJ
cord-012418-6ralcn8p	474	20	nuclear	nuclear	JJ
cord-012418-6ralcn8p	474	21	structures	structure	NNS
cord-012418-6ralcn8p	474	22	,	,	,
cord-012418-6ralcn8p	474	23	thereby	thereby	RB
cord-012418-6ralcn8p	474	24	sequestering	sequester	VBG
cord-012418-6ralcn8p	474	25	them	-PRON-	PRP
cord-012418-6ralcn8p	474	26	away	away	RB
cord-012418-6ralcn8p	474	27	from	from	IN
cord-012418-6ralcn8p	474	28	their	-PRON-	PRP$
cord-012418-6ralcn8p	474	29	site	site	NN
cord-012418-6ralcn8p	474	30	of	of	IN
cord-012418-6ralcn8p	474	31	activity	activity	NN
cord-012418-6ralcn8p	474	32	[	[	-LRB-
cord-012418-6ralcn8p	474	33	232	232	CD
cord-012418-6ralcn8p	474	34	]	]	-RRB-
cord-012418-6ralcn8p	474	35	.	.	.
cord-012418-6ralcn8p	475	1	Additionally	additionally	RB
cord-012418-6ralcn8p	475	2	,	,	,
cord-012418-6ralcn8p	475	3	this	this	DT
cord-012418-6ralcn8p	475	4	mediates	mediate	VBZ
cord-012418-6ralcn8p	475	5	deactivation	deactivation	NN
cord-012418-6ralcn8p	475	6	and	and	CC
cord-012418-6ralcn8p	475	7	promotes	promote	VBZ
cord-012418-6ralcn8p	475	8	degradation	degradation	NN
cord-012418-6ralcn8p	475	9	of	of	IN
cord-012418-6ralcn8p	475	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	475	11	.	.	.
cord-012418-6ralcn8p	476	1	The	the	DT
cord-012418-6ralcn8p	476	2	ICP0	ICP0	NNP
cord-012418-6ralcn8p	476	3	variant	variant	NN
cord-012418-6ralcn8p	476	4	of	of	IN
cord-012418-6ralcn8p	476	5	bovine	bovine	JJ
cord-012418-6ralcn8p	476	6	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	476	7	1	1	CD
cord-012418-6ralcn8p	476	8	(	(	-LRB-
cord-012418-6ralcn8p	476	9	BHV-1	BHV-1	NNP
cord-012418-6ralcn8p	476	10	)	)	-RRB-
cord-012418-6ralcn8p	476	11	also	also	RB
cord-012418-6ralcn8p	476	12	interacts	interact	VBZ
cord-012418-6ralcn8p	476	13	with	with	IN
cord-012418-6ralcn8p	476	14	p300	p300	NNP
cord-012418-6ralcn8p	476	15	,	,	,
cord-012418-6ralcn8p	476	16	but	but	CC
cord-012418-6ralcn8p	476	17	in	in	IN
cord-012418-6ralcn8p	476	18	contrast	contrast	NN
cord-012418-6ralcn8p	476	19	to	to	IN
cord-012418-6ralcn8p	476	20	HSV-1	HSV-1	NNP
cord-012418-6ralcn8p	476	21	,	,	,
cord-012418-6ralcn8p	476	22	this	this	DT
cord-012418-6ralcn8p	476	23	interaction	interaction	NN
cord-012418-6ralcn8p	476	24	hijacks	hijack	VBZ
cord-012418-6ralcn8p	476	25	the	the	DT
cord-012418-6ralcn8p	476	26	acetyltransferase	acetyltransferase	NN
cord-012418-6ralcn8p	476	27	activity	activity	NN
cord-012418-6ralcn8p	476	28	of	of	IN
cord-012418-6ralcn8p	476	29	the	the	DT
cord-012418-6ralcn8p	476	30	coactivator	coactivator	NN
cord-012418-6ralcn8p	476	31	and	and	CC
cord-012418-6ralcn8p	476	32	activates	activate	VBZ
cord-012418-6ralcn8p	476	33	expression	expression	NN
cord-012418-6ralcn8p	476	34	from	from	IN
cord-012418-6ralcn8p	476	35	viral	viral	JJ
cord-012418-6ralcn8p	476	36	promoters	promoter	NNS
cord-012418-6ralcn8p	476	37	[	[	-LRB-
cord-012418-6ralcn8p	476	38	233	233	CD
cord-012418-6ralcn8p	476	39	]	]	-RRB-
cord-012418-6ralcn8p	476	40	.	.	.
cord-012418-6ralcn8p	477	1	(	(	-LRB-
cord-012418-6ralcn8p	477	2	ii	ii	NN
cord-012418-6ralcn8p	477	3	)	)	-RRB-
cord-012418-6ralcn8p	478	1	The	the	DT
cord-012418-6ralcn8p	478	2	kinase	kinase	NN
cord-012418-6ralcn8p	478	3	BGLF4	bglf4	NN
cord-012418-6ralcn8p	478	4	of	of	IN
cord-012418-6ralcn8p	478	5	Epstein	Epstein	NNP
cord-012418-6ralcn8p	478	6	-	-	HYPH
cord-012418-6ralcn8p	478	7	Bar	Bar	NNP
cord-012418-6ralcn8p	478	8	virus	virus	NN
cord-012418-6ralcn8p	478	9	(	(	-LRB-
cord-012418-6ralcn8p	478	10	EBV	EBV	NNP
cord-012418-6ralcn8p	478	11	)	)	-RRB-
cord-012418-6ralcn8p	478	12	directly	directly	RB
cord-012418-6ralcn8p	478	13	interacts	interact	VBZ
cord-012418-6ralcn8p	478	14	with	with	IN
cord-012418-6ralcn8p	478	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	478	16	and	and	CC
cord-012418-6ralcn8p	478	17	phosphorylates	phosphorylate	VBZ
cord-012418-6ralcn8p	478	18	several	several	JJ
cord-012418-6ralcn8p	478	19	residues	residue	NNS
cord-012418-6ralcn8p	478	20	between	between	IN
cord-012418-6ralcn8p	478	21	DBD	DBD	NNP
cord-012418-6ralcn8p	478	22	and	and	CC
cord-012418-6ralcn8p	478	23	IAD	IAD	NNP
cord-012418-6ralcn8p	478	24	[	[	-LRB-
cord-012418-6ralcn8p	478	25	234	234	CD
cord-012418-6ralcn8p	478	26	]	]	-RRB-
cord-012418-6ralcn8p	478	27	.	.	.
cord-012418-6ralcn8p	479	1	Without	without	IN
cord-012418-6ralcn8p	479	2	affecting	affect	VBG
cord-012418-6ralcn8p	479	3	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	479	4	or	or	CC
cord-012418-6ralcn8p	479	5	association	association	NN
cord-012418-6ralcn8p	479	6	with	with	IN
cord-012418-6ralcn8p	479	7	CBP	CBP	NNP
cord-012418-6ralcn8p	479	8	,	,	,
cord-012418-6ralcn8p	479	9	this	this	DT
cord-012418-6ralcn8p	479	10	modification	modification	NN
cord-012418-6ralcn8p	479	11	prevents	prevent	VBZ
cord-012418-6ralcn8p	479	12	binding	bind	VBG
cord-012418-6ralcn8p	479	13	of	of	IN
cord-012418-6ralcn8p	479	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	479	15	to	to	TO
cord-012418-6ralcn8p	479	16	DNA	DNA	NNP
cord-012418-6ralcn8p	479	17	.	.	.
cord-012418-6ralcn8p	480	1	(	(	-LRB-
cord-012418-6ralcn8p	480	2	iii	iii	NN
cord-012418-6ralcn8p	480	3	)	)	-RRB-
cord-012418-6ralcn8p	481	1	KSHV	KSHV	NNP
cord-012418-6ralcn8p	481	2	latency	latency	NN
cord-012418-6ralcn8p	481	3	-	-	HYPH
cord-012418-6ralcn8p	481	4	associated	associate	VBN
cord-012418-6ralcn8p	481	5	nuclear	nuclear	JJ
cord-012418-6ralcn8p	481	6	antigen	antigen	NN
cord-012418-6ralcn8p	481	7	1	1	CD
cord-012418-6ralcn8p	481	8	(	(	-LRB-
cord-012418-6ralcn8p	481	9	LANA-1	LANA-1	NNP
cord-012418-6ralcn8p	481	10	)	)	-RRB-
cord-012418-6ralcn8p	481	11	competes	compete	VBZ
cord-012418-6ralcn8p	481	12	with	with	IN
cord-012418-6ralcn8p	481	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	481	14	for	for	IN
cord-012418-6ralcn8p	481	15	binding	bind	VBG
cord-012418-6ralcn8p	481	16	to	to	IN
cord-012418-6ralcn8p	481	17	the	the	DT
cord-012418-6ralcn8p	481	18	PRDIII	PRDIII	NNP
cord-012418-6ralcn8p	481	19	-	-	HYPH
cord-012418-6ralcn8p	481	20	I	I	NNP
cord-012418-6ralcn8p	481	21	region	region	NN
cord-012418-6ralcn8p	481	22	and	and	CC
cord-012418-6ralcn8p	481	23	in	in	IN
cord-012418-6ralcn8p	481	24	this	this	DT
cord-012418-6ralcn8p	481	25	way	way	NN
cord-012418-6ralcn8p	481	26	interferes	interfere	VBZ
cord-012418-6ralcn8p	481	27	with	with	IN
cord-012418-6ralcn8p	481	28	stable	stable	JJ
cord-012418-6ralcn8p	481	29	association	association	NN
cord-012418-6ralcn8p	481	30	of	of	IN
cord-012418-6ralcn8p	481	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	481	32	to	to	IN
cord-012418-6ralcn8p	481	33	the	the	DT
cord-012418-6ralcn8p	481	34	target	target	NN
cord-012418-6ralcn8p	481	35	DNA	dna	NN
cord-012418-6ralcn8p	481	36	[	[	-LRB-
cord-012418-6ralcn8p	481	37	235	235	CD
cord-012418-6ralcn8p	481	38	]	]	-RRB-
cord-012418-6ralcn8p	481	39	.	.	.
cord-012418-6ralcn8p	482	1	The	the	DT
cord-012418-6ralcn8p	482	2	DNA	dna	NN
cord-012418-6ralcn8p	482	3	polymerase	polymerase	NN
cord-012418-6ralcn8p	482	4	subunit	subunit	NN
cord-012418-6ralcn8p	482	5	UL44	UL44	NNP
cord-012418-6ralcn8p	482	6	of	of	IN
cord-012418-6ralcn8p	482	7	HCMV	HCMV	NNP
cord-012418-6ralcn8p	482	8	was	be	VBD
cord-012418-6ralcn8p	482	9	recently	recently	RB
cord-012418-6ralcn8p	482	10	reported	report	VBN
cord-012418-6ralcn8p	482	11	to	to	TO
cord-012418-6ralcn8p	482	12	act	act	VB
cord-012418-6ralcn8p	482	13	in	in	IN
cord-012418-6ralcn8p	482	14	a	a	DT
cord-012418-6ralcn8p	482	15	similar	similar	JJ
cord-012418-6ralcn8p	482	16	way	way	NN
cord-012418-6ralcn8p	482	17	[	[	-LRB-
cord-012418-6ralcn8p	482	18	236	236	CD
cord-012418-6ralcn8p	482	19	]	]	-RRB-
cord-012418-6ralcn8p	482	20	:	:	:
cord-012418-6ralcn8p	482	21	Upon	upon	IN
cord-012418-6ralcn8p	482	22	HCMV	HCMV	NNP
cord-012418-6ralcn8p	482	23	infection	infection	NN
cord-012418-6ralcn8p	482	24	,	,	,
cord-012418-6ralcn8p	482	25	exogenously	exogenously	RB
cord-012418-6ralcn8p	482	26	expressed	express	VBD
cord-012418-6ralcn8p	482	27	UL44	UL44	NNP
cord-012418-6ralcn8p	482	28	could	could	MD
cord-012418-6ralcn8p	482	29	be	be	VB
cord-012418-6ralcn8p	482	30	demonstrated	demonstrate	VBN
cord-012418-6ralcn8p	482	31	to	to	TO
cord-012418-6ralcn8p	482	32	associate	associate	VB
cord-012418-6ralcn8p	482	33	with	with	IN
cord-012418-6ralcn8p	482	34	the	the	DT
cord-012418-6ralcn8p	482	35	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	482	36	promoter	promoter	NN
cord-012418-6ralcn8p	482	37	region	region	NN
cord-012418-6ralcn8p	482	38	in	in	IN
cord-012418-6ralcn8p	482	39	a	a	DT
cord-012418-6ralcn8p	482	40	chromatin	chromatin	NN
cord-012418-6ralcn8p	482	41	immunoprecipitation	immunoprecipitation	NN
cord-012418-6ralcn8p	482	42	assay	assay	NN
cord-012418-6ralcn8p	482	43	and	and	CC
cord-012418-6ralcn8p	482	44	in	in	IN
cord-012418-6ralcn8p	482	45	parallel	parallel	JJ
cord-012418-6ralcn8p	482	46	UL44	UL44	NNP
cord-012418-6ralcn8p	482	47	interfered	interfere	VBD
cord-012418-6ralcn8p	482	48	with	with	IN
cord-012418-6ralcn8p	482	49	binding	binding	NN
cord-012418-6ralcn8p	482	50	of	of	IN
cord-012418-6ralcn8p	482	51	the	the	DT
cord-012418-6ralcn8p	482	52	central	central	JJ
cord-012418-6ralcn8p	482	53	transcription	transcription	NN
cord-012418-6ralcn8p	482	54	factors	factor	NNS
cord-012418-6ralcn8p	482	55	IRF3	IRF3	NNP
cord-012418-6ralcn8p	482	56	and	and	CC
cord-012418-6ralcn8p	482	57	p65	p65	ADD
cord-012418-6ralcn8p	482	58	.	.	.
cord-012418-6ralcn8p	483	1	Additionally	additionally	RB
cord-012418-6ralcn8p	483	2	,	,	,
cord-012418-6ralcn8p	483	3	UL44	UL44	NNP
cord-012418-6ralcn8p	483	4	interacts	interact	VBZ
cord-012418-6ralcn8p	483	5	with	with	IN
cord-012418-6ralcn8p	483	6	both	both	DT
cord-012418-6ralcn8p	483	7	transcription	transcription	NN
cord-012418-6ralcn8p	483	8	factors	factor	NNS
cord-012418-6ralcn8p	483	9	irrespective	irrespective	RB
cord-012418-6ralcn8p	483	10	of	of	IN
cord-012418-6ralcn8p	483	11	their	-PRON-	PRP$
cord-012418-6ralcn8p	483	12	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	483	13	status	status	NN
cord-012418-6ralcn8p	483	14	.	.	.
cord-012418-6ralcn8p	484	1	(	(	-LRB-
cord-012418-6ralcn8p	484	2	iv	iv	LS
cord-012418-6ralcn8p	484	3	)	)	-RRB-
cord-012418-6ralcn8p	485	1	The	the	DT
cord-012418-6ralcn8p	485	2	KSHV	KSHV	NNP
cord-012418-6ralcn8p	485	3	protein	protein	NN
cord-012418-6ralcn8p	485	4	K	K	NNP
cord-012418-6ralcn8p	485	5	-	-	HYPH
cord-012418-6ralcn8p	485	6	bZIP	bZIP	NNP
cord-012418-6ralcn8p	485	7	binds	bind	NNS
cord-012418-6ralcn8p	485	8	to	to	IN
cord-012418-6ralcn8p	485	9	the	the	DT
cord-012418-6ralcn8p	485	10	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	485	11	promoter	promoter	NN
cord-012418-6ralcn8p	485	12	region	region	NN
cord-012418-6ralcn8p	485	13	itself	-PRON-	PRP
cord-012418-6ralcn8p	485	14	and	and	CC
cord-012418-6ralcn8p	485	15	prevents	prevent	VBZ
cord-012418-6ralcn8p	485	16	binding	binding	NN
cord-012418-6ralcn8p	485	17	of	of	IN
cord-012418-6ralcn8p	485	18	IRF3	IRF3	NNP
cord-012418-6ralcn8p	485	19	[	[	-LRB-
cord-012418-6ralcn8p	485	20	237	237	CD
cord-012418-6ralcn8p	485	21	]	]	-RRB-
cord-012418-6ralcn8p	485	22	,	,	,
cord-012418-6ralcn8p	485	23	but	but	CC
cord-012418-6ralcn8p	485	24	differently	differently	RB
cord-012418-6ralcn8p	485	25	from	from	IN
cord-012418-6ralcn8p	485	26	LANA-1	LANA-1	NNP
cord-012418-6ralcn8p	485	27	and	and	CC
cord-012418-6ralcn8p	485	28	UL44	UL44	NNP
cord-012418-6ralcn8p	485	29	,	,	,
cord-012418-6ralcn8p	485	30	K	K	NNP
cord-012418-6ralcn8p	485	31	-	-	HYPH
cord-012418-6ralcn8p	485	32	bZIP	bZIP	NNP
cord-012418-6ralcn8p	485	33	weakly	weakly	RB
cord-012418-6ralcn8p	485	34	induces	induce	VBZ
cord-012418-6ralcn8p	485	35	gene	gene	NN
cord-012418-6ralcn8p	485	36	expression	expression	NN
cord-012418-6ralcn8p	485	37	while	while	IN
cord-012418-6ralcn8p	485	38	it	-PRON-	PRP
cord-012418-6ralcn8p	485	39	prevents	prevent	VBZ
cord-012418-6ralcn8p	485	40	a	a	DT
cord-012418-6ralcn8p	485	41	high	high	JJ
cord-012418-6ralcn8p	485	42	and	and	CC
cord-012418-6ralcn8p	485	43	detrimental	detrimental	JJ
cord-012418-6ralcn8p	485	44	activation	activation	NN
cord-012418-6ralcn8p	485	45	of	of	IN
cord-012418-6ralcn8p	485	46	the	the	DT
cord-012418-6ralcn8p	485	47	type	type	NN
cord-012418-6ralcn8p	485	48	I	-PRON-	PRP
cord-012418-6ralcn8p	485	49	IFN	IFN	NNP
cord-012418-6ralcn8p	485	50	response	response	NN
cord-012418-6ralcn8p	485	51	.	.	.
cord-012418-6ralcn8p	486	1	In	in	IN
cord-012418-6ralcn8p	486	2	contrast	contrast	NN
cord-012418-6ralcn8p	486	3	,	,	,
cord-012418-6ralcn8p	486	4	the	the	DT
cord-012418-6ralcn8p	486	5	NSs	NSs	NNP
cord-012418-6ralcn8p	486	6	protein	protein	NN
cord-012418-6ralcn8p	486	7	of	of	IN
cord-012418-6ralcn8p	486	8	Rift	Rift	NNP
cord-012418-6ralcn8p	486	9	Valley	Valley	NNP
cord-012418-6ralcn8p	486	10	fever	fever	NN
cord-012418-6ralcn8p	486	11	virus	virus	NN
cord-012418-6ralcn8p	486	12	(	(	-LRB-
cord-012418-6ralcn8p	486	13	RVFV	RVFV	NNP
cord-012418-6ralcn8p	486	14	)	)	-RRB-
cord-012418-6ralcn8p	486	15	applies	apply	VBZ
cord-012418-6ralcn8p	486	16	a	a	DT
cord-012418-6ralcn8p	486	17	more	more	RBR
cord-012418-6ralcn8p	486	18	indirect	indirect	JJ
cord-012418-6ralcn8p	486	19	approach	approach	NN
cord-012418-6ralcn8p	486	20	to	to	TO
cord-012418-6ralcn8p	486	21	inhibit	inhibit	VB
cord-012418-6ralcn8p	486	22	binding	bind	VBG
cord-012418-6ralcn8p	486	23	of	of	IN
cord-012418-6ralcn8p	486	24	the	the	DT
cord-012418-6ralcn8p	486	25	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	486	26	/	/	SYM
cord-012418-6ralcn8p	486	27	p300	p300	NNP
cord-012418-6ralcn8p	486	28	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	486	29	[	[	-LRB-
cord-012418-6ralcn8p	486	30	238	238	CD
cord-012418-6ralcn8p	486	31	]	]	-RRB-
cord-012418-6ralcn8p	486	32	.	.	.
cord-012418-6ralcn8p	487	1	NSs	NSs	NNP
cord-012418-6ralcn8p	487	2	interacts	interact	VBZ
cord-012418-6ralcn8p	487	3	with	with	IN
cord-012418-6ralcn8p	487	4	the	the	DT
cord-012418-6ralcn8p	487	5	host	host	NN
cord-012418-6ralcn8p	487	6	factor	factor	NN
cord-012418-6ralcn8p	487	7	Sin3A	Sin3A	NNS
cord-012418-6ralcn8p	487	8	-	-	HYPH
cord-012418-6ralcn8p	487	9	associated	associate	VBN
cord-012418-6ralcn8p	487	10	protein	protein	NN
cord-012418-6ralcn8p	487	11	30	30	CD
cord-012418-6ralcn8p	487	12	(	(	-LRB-
cord-012418-6ralcn8p	487	13	SAP30	SAP30	NNP
cord-012418-6ralcn8p	487	14	)	)	-RRB-
cord-012418-6ralcn8p	487	15	,	,	,
cord-012418-6ralcn8p	487	16	which	which	WDT
cord-012418-6ralcn8p	487	17	belongs	belong	VBZ
cord-012418-6ralcn8p	487	18	to	to	IN
cord-012418-6ralcn8p	487	19	the	the	DT
cord-012418-6ralcn8p	487	20	Sin3A	Sin3A	NNS
cord-012418-6ralcn8p	487	21	/	/	SYM
cord-012418-6ralcn8p	487	22	NCoR	NCoR	NNP
cord-012418-6ralcn8p	487	23	/	/	SYM
cord-012418-6ralcn8p	487	24	HDACs	hdac	NNS
cord-012418-6ralcn8p	487	25	repressor	repressor	NN
cord-012418-6ralcn8p	487	26	complexes	complex	NNS
cord-012418-6ralcn8p	487	27	.	.	.
cord-012418-6ralcn8p	488	1	In	in	IN
cord-012418-6ralcn8p	488	2	turn	turn	NN
cord-012418-6ralcn8p	488	3	,	,	,
cord-012418-6ralcn8p	488	4	SAP30	SAP30	NNP
cord-012418-6ralcn8p	488	5	interacts	interact	VBZ
cord-012418-6ralcn8p	488	6	with	with	IN
cord-012418-6ralcn8p	488	7	the	the	DT
cord-012418-6ralcn8p	488	8	transcription	transcription	NN
cord-012418-6ralcn8p	488	9	factor	factor	NN
cord-012418-6ralcn8p	488	10	YY1	YY1	NNP
cord-012418-6ralcn8p	488	11	,	,	,
cord-012418-6ralcn8p	488	12	and	and	CC
cord-012418-6ralcn8p	488	13	this	this	DT
cord-012418-6ralcn8p	488	14	interaction	interaction	NN
cord-012418-6ralcn8p	488	15	enables	enable	VBZ
cord-012418-6ralcn8p	488	16	recruitment	recruitment	NN
cord-012418-6ralcn8p	488	17	of	of	IN
cord-012418-6ralcn8p	488	18	NSs	NSs	NNP
cord-012418-6ralcn8p	488	19	and	and	CC
cord-012418-6ralcn8p	488	20	SAP30	SAP30	NNP
cord-012418-6ralcn8p	488	21	to	to	IN
cord-012418-6ralcn8p	488	22	the	the	DT
cord-012418-6ralcn8p	488	23	murine	murine	JJ
cord-012418-6ralcn8p	488	24	IFNβ	IFNβ	NNS
cord-012418-6ralcn8p	488	25	promoter	promoter	NN
cord-012418-6ralcn8p	488	26	region	region	NN
cord-012418-6ralcn8p	488	27	.	.	.
cord-012418-6ralcn8p	489	1	Finally	finally	RB
cord-012418-6ralcn8p	489	2	,	,	,
cord-012418-6ralcn8p	489	3	the	the	DT
cord-012418-6ralcn8p	489	4	presence	presence	NN
cord-012418-6ralcn8p	489	5	of	of	IN
cord-012418-6ralcn8p	489	6	the	the	DT
cord-012418-6ralcn8p	489	7	NSs	NSs	NNP
cord-012418-6ralcn8p	489	8	-	-	HYPH
cord-012418-6ralcn8p	489	9	SAP30-YY1	SAP30-YY1	NNP
cord-012418-6ralcn8p	489	10	complex	complex	NN
cord-012418-6ralcn8p	489	11	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	489	12	recruitment	recruitment	NN
cord-012418-6ralcn8p	489	13	of	of	IN
cord-012418-6ralcn8p	489	14	CBP	CBP	NNP
cord-012418-6ralcn8p	489	15	and	and	CC
cord-012418-6ralcn8p	489	16	thus	thus	RB
cord-012418-6ralcn8p	489	17	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	489	18	activation	activation	NN
cord-012418-6ralcn8p	489	19	of	of	IN
cord-012418-6ralcn8p	489	20	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	489	21	.	.	.
cord-012418-6ralcn8p	490	1	Since	since	IN
cord-012418-6ralcn8p	490	2	the	the	DT
cord-012418-6ralcn8p	490	3	beginning	beginning	NN
cord-012418-6ralcn8p	490	4	of	of	IN
cord-012418-6ralcn8p	490	5	the	the	DT
cord-012418-6ralcn8p	490	6	detailed	detailed	JJ
cord-012418-6ralcn8p	490	7	characterisation	characterisation	NN
cord-012418-6ralcn8p	490	8	of	of	IN
cord-012418-6ralcn8p	490	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	490	10	activation	activation	NN
cord-012418-6ralcn8p	490	11	more	more	JJR
cord-012418-6ralcn8p	490	12	than	than	IN
cord-012418-6ralcn8p	490	13	20	20	CD
cord-012418-6ralcn8p	490	14	years	year	NNS
cord-012418-6ralcn8p	490	15	ago	ago	RB
cord-012418-6ralcn8p	490	16	,	,	,
cord-012418-6ralcn8p	490	17	we	-PRON-	PRP
cord-012418-6ralcn8p	490	18	have	have	VBP
cord-012418-6ralcn8p	490	19	gained	gain	VBN
cord-012418-6ralcn8p	490	20	profound	profound	JJ
cord-012418-6ralcn8p	490	21	insight	insight	NN
cord-012418-6ralcn8p	490	22	into	into	IN
cord-012418-6ralcn8p	490	23	the	the	DT
cord-012418-6ralcn8p	490	24	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	490	25	enabling	enable	VBG
cord-012418-6ralcn8p	490	26	the	the	DT
cord-012418-6ralcn8p	490	27	trans	trans	JJ
cord-012418-6ralcn8p	490	28	-	-	JJ
cord-012418-6ralcn8p	490	29	activation	activation	JJ
cord-012418-6ralcn8p	490	30	activity	activity	NN
cord-012418-6ralcn8p	490	31	of	of	IN
cord-012418-6ralcn8p	490	32	a	a	DT
cord-012418-6ralcn8p	490	33	transcription	transcription	NN
cord-012418-6ralcn8p	490	34	factor	factor	NN
cord-012418-6ralcn8p	490	35	with	with	IN
cord-012418-6ralcn8p	490	36	low	low	JJ
cord-012418-6ralcn8p	490	37	intrinsic	intrinsic	JJ
cord-012418-6ralcn8p	490	38	binding	bind	VBG
cord-012418-6ralcn8p	490	39	affinity	affinity	NN
cord-012418-6ralcn8p	490	40	for	for	IN
cord-012418-6ralcn8p	490	41	its	-PRON-	PRP$
cord-012418-6ralcn8p	490	42	specific	specific	JJ
cord-012418-6ralcn8p	490	43	recognition	recognition	NN
cord-012418-6ralcn8p	490	44	motif	motif	NN
cord-012418-6ralcn8p	490	45	and	and	CC
cord-012418-6ralcn8p	490	46	into	into	IN
cord-012418-6ralcn8p	490	47	the	the	DT
cord-012418-6ralcn8p	490	48	intricate	intricate	JJ
cord-012418-6ralcn8p	490	49	network	network	NN
cord-012418-6ralcn8p	490	50	of	of	IN
cord-012418-6ralcn8p	490	51	interactions	interaction	NNS
cord-012418-6ralcn8p	490	52	that	that	WDT
cord-012418-6ralcn8p	490	53	allow	allow	VBP
cord-012418-6ralcn8p	490	54	its	-PRON-	PRP$
cord-012418-6ralcn8p	490	55	participation	participation	NN
cord-012418-6ralcn8p	490	56	in	in	IN
cord-012418-6ralcn8p	490	57	the	the	DT
cord-012418-6ralcn8p	490	58	induction	induction	NN
cord-012418-6ralcn8p	490	59	of	of	IN
cord-012418-6ralcn8p	490	60	IFNB1	ifnb1	DT
cord-012418-6ralcn8p	490	61	expression	expression	NN
cord-012418-6ralcn8p	490	62	.	.	.
cord-012418-6ralcn8p	491	1	Still	still	RB
cord-012418-6ralcn8p	491	2	,	,	,
cord-012418-6ralcn8p	491	3	the	the	DT
cord-012418-6ralcn8p	491	4	fundamental	fundamental	JJ
cord-012418-6ralcn8p	491	5	principles	principle	NNS
cord-012418-6ralcn8p	491	6	were	be	VBD
cord-012418-6ralcn8p	491	7	mostly	mostly	RB
cord-012418-6ralcn8p	491	8	characterised	characterise	VBN
cord-012418-6ralcn8p	491	9	in	in	IN
cord-012418-6ralcn8p	491	10	vitro	vitro	FW
cord-012418-6ralcn8p	491	11	and	and	CC
cord-012418-6ralcn8p	491	12	sometimes	sometimes	RB
cord-012418-6ralcn8p	491	13	biased	biased	JJ
cord-012418-6ralcn8p	491	14	from	from	IN
cord-012418-6ralcn8p	491	15	prior	prior	JJ
cord-012418-6ralcn8p	491	16	assumptions	assumption	NNS
cord-012418-6ralcn8p	491	17	,	,	,
cord-012418-6ralcn8p	491	18	rendering	render	VBG
cord-012418-6ralcn8p	491	19	the	the	DT
cord-012418-6ralcn8p	491	20	sequence	sequence	NN
cord-012418-6ralcn8p	491	21	of	of	IN
cord-012418-6ralcn8p	491	22	events	event	NNS
cord-012418-6ralcn8p	491	23	as	as	IN
cord-012418-6ralcn8p	491	24	it	-PRON-	PRP
cord-012418-6ralcn8p	491	25	occurs	occur	VBZ
cord-012418-6ralcn8p	491	26	in	in	IN
cord-012418-6ralcn8p	491	27	our	-PRON-	PRP$
cord-012418-6ralcn8p	491	28	cells	cell	NNS
cord-012418-6ralcn8p	491	29	incomplete	incomplete	JJ
cord-012418-6ralcn8p	491	30	.	.	.
cord-012418-6ralcn8p	492	1	To	to	TO
cord-012418-6ralcn8p	492	2	reveal	reveal	VB
cord-012418-6ralcn8p	492	3	the	the	DT
cord-012418-6ralcn8p	492	4	full	full	JJ
cord-012418-6ralcn8p	492	5	dynamics	dynamic	NNS
cord-012418-6ralcn8p	492	6	of	of	IN
cord-012418-6ralcn8p	492	7	the	the	DT
cord-012418-6ralcn8p	492	8	events	event	NNS
cord-012418-6ralcn8p	492	9	summarised	summarise	VBN
cord-012418-6ralcn8p	492	10	above	above	RB
cord-012418-6ralcn8p	492	11	,	,	,
cord-012418-6ralcn8p	492	12	experiments	experiment	NNS
cord-012418-6ralcn8p	492	13	with	with	IN
cord-012418-6ralcn8p	492	14	living	living	NN
cord-012418-6ralcn8p	492	15	cells	cell	NNS
cord-012418-6ralcn8p	492	16	will	will	MD
cord-012418-6ralcn8p	492	17	be	be	VB
cord-012418-6ralcn8p	492	18	required	require	VBN
cord-012418-6ralcn8p	492	19	.	.	.
cord-012418-6ralcn8p	493	1	The	the	DT
cord-012418-6ralcn8p	493	2	many	many	JJ
cord-012418-6ralcn8p	493	3	studies	study	NNS
cord-012418-6ralcn8p	493	4	reporting	report	VBG
cord-012418-6ralcn8p	493	5	factors	factor	NNS
cord-012418-6ralcn8p	493	6	that	that	WDT
cord-012418-6ralcn8p	493	7	affect	affect	VBP
cord-012418-6ralcn8p	493	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	493	9	dimerisation	dimerisation	NN
cord-012418-6ralcn8p	493	10	and/or	and/or	CC
cord-012418-6ralcn8p	493	11	translocation	translocation	NN
cord-012418-6ralcn8p	493	12	and/or	and/or	CC
cord-012418-6ralcn8p	493	13	trans	trans	JJ
cord-012418-6ralcn8p	493	14	-	-	JJ
cord-012418-6ralcn8p	493	15	activation	activation	NN
cord-012418-6ralcn8p	493	16	activity	activity	NN
cord-012418-6ralcn8p	493	17	highlight	highlight	VBP
cord-012418-6ralcn8p	493	18	the	the	DT
cord-012418-6ralcn8p	493	19	importance	importance	NN
cord-012418-6ralcn8p	493	20	of	of	IN
cord-012418-6ralcn8p	493	21	pinpointing	pinpoint	VBG
cord-012418-6ralcn8p	493	22	the	the	DT
cord-012418-6ralcn8p	493	23	modulatory	modulatory	JJ
cord-012418-6ralcn8p	493	24	mechanism	mechanism	NN
cord-012418-6ralcn8p	493	25	as	as	RB
cord-012418-6ralcn8p	493	26	precisely	precisely	RB
cord-012418-6ralcn8p	493	27	as	as	IN
cord-012418-6ralcn8p	493	28	possible	possible	JJ
cord-012418-6ralcn8p	493	29	in	in	IN
cord-012418-6ralcn8p	493	30	future	future	JJ
cord-012418-6ralcn8p	493	31	work	work	NN
cord-012418-6ralcn8p	493	32	.	.	.
cord-012418-6ralcn8p	494	1	At	at	IN
cord-012418-6ralcn8p	494	2	the	the	DT
cord-012418-6ralcn8p	494	3	same	same	JJ
cord-012418-6ralcn8p	494	4	time	time	NN
cord-012418-6ralcn8p	494	5	,	,	,
cord-012418-6ralcn8p	494	6	the	the	DT
cord-012418-6ralcn8p	494	7	diversity	diversity	NN
cord-012418-6ralcn8p	494	8	of	of	IN
cord-012418-6ralcn8p	494	9	methods	method	NNS
cord-012418-6ralcn8p	494	10	applied	apply	VBN
cord-012418-6ralcn8p	494	11	in	in	IN
cord-012418-6ralcn8p	494	12	the	the	DT
cord-012418-6ralcn8p	494	13	studies	study	NNS
cord-012418-6ralcn8p	494	14	summarised	summarise	VBN
cord-012418-6ralcn8p	494	15	here	here	RB
cord-012418-6ralcn8p	494	16	demonstrates	demonstrate	VBZ
cord-012418-6ralcn8p	494	17	that	that	IN
cord-012418-6ralcn8p	494	18	nowadays	nowadays	RB
cord-012418-6ralcn8p	494	19	,	,	,
cord-012418-6ralcn8p	494	20	dissection	dissection	NN
cord-012418-6ralcn8p	494	21	of	of	IN
cord-012418-6ralcn8p	494	22	the	the	DT
cord-012418-6ralcn8p	494	23	exact	exact	JJ
cord-012418-6ralcn8p	494	24	level	level	NN
cord-012418-6ralcn8p	494	25	of	of	IN
cord-012418-6ralcn8p	494	26	intervention	intervention	NN
cord-012418-6ralcn8p	494	27	with	with	IN
cord-012418-6ralcn8p	494	28	IRF3	IRF3	NNP
cord-012418-6ralcn8p	494	29	activity	activity	NN
cord-012418-6ralcn8p	494	30	is	be	VBZ
cord-012418-6ralcn8p	494	31	within	within	IN
cord-012418-6ralcn8p	494	32	reach	reach	NN
cord-012418-6ralcn8p	494	33	.	.	.
cord-012418-6ralcn8p	495	1	As	as	IN
cord-012418-6ralcn8p	495	2	delineated	delineate	VBN
cord-012418-6ralcn8p	495	3	in	in	IN
cord-012418-6ralcn8p	495	4	this	this	DT
cord-012418-6ralcn8p	495	5	review	review	NN
cord-012418-6ralcn8p	495	6	,	,	,
cord-012418-6ralcn8p	495	7	the	the	DT
cord-012418-6ralcn8p	495	8	regulation	regulation	NN
cord-012418-6ralcn8p	495	9	of	of	IN
cord-012418-6ralcn8p	495	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	495	11	in	in	IN
cord-012418-6ralcn8p	495	12	the	the	DT
cord-012418-6ralcn8p	495	13	context	context	NN
cord-012418-6ralcn8p	495	14	of	of	IN
cord-012418-6ralcn8p	495	15	IFNB1	ifnb1	JJ
cord-012418-6ralcn8p	495	16	expression	expression	NN
cord-012418-6ralcn8p	495	17	in	in	IN
cord-012418-6ralcn8p	495	18	itself	-PRON-	PRP
cord-012418-6ralcn8p	495	19	presents	present	VBZ
cord-012418-6ralcn8p	495	20	us	-PRON-	PRP
cord-012418-6ralcn8p	495	21	with	with	IN
cord-012418-6ralcn8p	495	22	a	a	DT
cord-012418-6ralcn8p	495	23	multi	multi	JJ
cord-012418-6ralcn8p	495	24	-	-	JJ
cord-012418-6ralcn8p	495	25	layered	layered	JJ
cord-012418-6ralcn8p	495	26	circuit	circuit	NN
cord-012418-6ralcn8p	495	27	of	of	IN
cord-012418-6ralcn8p	495	28	promoting	promote	VBG
cord-012418-6ralcn8p	495	29	and	and	CC
cord-012418-6ralcn8p	495	30	dampening	dampen	VBG
cord-012418-6ralcn8p	495	31	modulations	modulation	NNS
cord-012418-6ralcn8p	495	32	.	.	.
cord-012418-6ralcn8p	496	1	The	the	DT
cord-012418-6ralcn8p	496	2	ever	ever	RB
cord-012418-6ralcn8p	496	3	-	-	HYPH
cord-012418-6ralcn8p	496	4	expanding	expand	VBG
cord-012418-6ralcn8p	496	5	catalogue	catalogue	NN
cord-012418-6ralcn8p	496	6	of	of	IN
cord-012418-6ralcn8p	496	7	host	host	NN
cord-012418-6ralcn8p	496	8	and	and	CC
cord-012418-6ralcn8p	496	9	viral	viral	JJ
cord-012418-6ralcn8p	496	10	modulators	modulator	NNS
cord-012418-6ralcn8p	496	11	of	of	IN
cord-012418-6ralcn8p	496	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	496	13	activity	activity	NN
cord-012418-6ralcn8p	496	14	not	not	RB
cord-012418-6ralcn8p	496	15	only	only	RB
cord-012418-6ralcn8p	496	16	reflects	reflect	VBZ
cord-012418-6ralcn8p	496	17	the	the	DT
cord-012418-6ralcn8p	496	18	key	key	JJ
cord-012418-6ralcn8p	496	19	role	role	NN
cord-012418-6ralcn8p	496	20	of	of	IN
cord-012418-6ralcn8p	496	21	this	this	DT
cord-012418-6ralcn8p	496	22	signalling	signal	VBG
cord-012418-6ralcn8p	496	23	pathway	pathway	NN
cord-012418-6ralcn8p	496	24	in	in	IN
cord-012418-6ralcn8p	496	25	the	the	DT
cord-012418-6ralcn8p	496	26	mammalian	mammalian	JJ
cord-012418-6ralcn8p	496	27	arsenal	arsenal	NN
cord-012418-6ralcn8p	496	28	of	of	IN
cord-012418-6ralcn8p	496	29	antiviral	antiviral	JJ
cord-012418-6ralcn8p	496	30	defence	defence	NN
cord-012418-6ralcn8p	496	31	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	496	32	,	,	,
cord-012418-6ralcn8p	496	33	but	but	CC
cord-012418-6ralcn8p	496	34	it	-PRON-	PRP
cord-012418-6ralcn8p	496	35	further	further	RB
cord-012418-6ralcn8p	496	36	alludes	allude	VBZ
cord-012418-6ralcn8p	496	37	to	to	IN
cord-012418-6ralcn8p	496	38	the	the	DT
cord-012418-6ralcn8p	496	39	possibility	possibility	NN
cord-012418-6ralcn8p	496	40	to	to	TO
cord-012418-6ralcn8p	496	41	use	use	VB
cord-012418-6ralcn8p	496	42	specific	specific	JJ
cord-012418-6ralcn8p	496	43	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	496	44	for	for	IN
cord-012418-6ralcn8p	496	45	medical	medical	JJ
cord-012418-6ralcn8p	496	46	intervention	intervention	NN
cord-012418-6ralcn8p	496	47	.	.	.
cord-012418-6ralcn8p	497	1	Directed	direct	VBN
cord-012418-6ralcn8p	497	2	manipulation	manipulation	NN
cord-012418-6ralcn8p	497	3	of	of	IN
cord-012418-6ralcn8p	497	4	host	host	NN
cord-012418-6ralcn8p	497	5	modulators	modulator	NNS
cord-012418-6ralcn8p	497	6	could	could	MD
cord-012418-6ralcn8p	497	7	present	present	VB
cord-012418-6ralcn8p	497	8	a	a	DT
cord-012418-6ralcn8p	497	9	novel	novel	JJ
cord-012418-6ralcn8p	497	10	approach	approach	NN
cord-012418-6ralcn8p	497	11	to	to	TO
cord-012418-6ralcn8p	497	12	stimulate	stimulate	VB
cord-012418-6ralcn8p	497	13	the	the	DT
cord-012418-6ralcn8p	497	14	host	host	NN
cord-012418-6ralcn8p	497	15	organism	organism	NN
cord-012418-6ralcn8p	497	16	to	to	TO
cord-012418-6ralcn8p	497	17	overcome	overcome	VB
cord-012418-6ralcn8p	497	18	an	an	DT
cord-012418-6ralcn8p	497	19	infection	infection	NN
cord-012418-6ralcn8p	497	20	by	by	IN
cord-012418-6ralcn8p	497	21	its	-PRON-	PRP$
cord-012418-6ralcn8p	497	22	own	own	JJ
cord-012418-6ralcn8p	497	23	resources	resource	NNS
cord-012418-6ralcn8p	497	24	or	or	CC
cord-012418-6ralcn8p	497	25	to	to	TO
cord-012418-6ralcn8p	497	26	reduce	reduce	VB
cord-012418-6ralcn8p	497	27	excessive	excessive	JJ
cord-012418-6ralcn8p	497	28	IFN	IFN	NNP
cord-012418-6ralcn8p	497	29	activity	activity	NN
cord-012418-6ralcn8p	497	30	to	to	IN
cord-012418-6ralcn8p	497	31	healthy	healthy	JJ
cord-012418-6ralcn8p	497	32	levels	level	NNS
cord-012418-6ralcn8p	497	33	.	.	.
cord-012418-6ralcn8p	498	1	More	More	JJR
cord-012418-6ralcn8p	498	2	information	information	NN
cord-012418-6ralcn8p	498	3	on	on	IN
cord-012418-6ralcn8p	498	4	how	how	WRB
cord-012418-6ralcn8p	498	5	to	to	TO
cord-012418-6ralcn8p	498	6	achieve	achieve	VB
cord-012418-6ralcn8p	498	7	this	this	DT
cord-012418-6ralcn8p	498	8	will	will	MD
cord-012418-6ralcn8p	498	9	surely	surely	RB
cord-012418-6ralcn8p	498	10	emerge	emerge	VB
cord-012418-6ralcn8p	498	11	from	from	IN
cord-012418-6ralcn8p	498	12	the	the	DT
cord-012418-6ralcn8p	498	13	unceasing	unceasing	JJ
cord-012418-6ralcn8p	498	14	identification	identification	NN
cord-012418-6ralcn8p	498	15	and	and	CC
cord-012418-6ralcn8p	498	16	characterisation	characterisation	NN
cord-012418-6ralcn8p	498	17	of	of	IN
cord-012418-6ralcn8p	498	18	novel	novel	JJ
cord-012418-6ralcn8p	498	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	498	20	modulators	modulator	NNS
cord-012418-6ralcn8p	498	21	deployed	deploy	VBN
cord-012418-6ralcn8p	498	22	by	by	IN
cord-012418-6ralcn8p	498	23	host	host	NN
cord-012418-6ralcn8p	498	24	and	and	CC
cord-012418-6ralcn8p	498	25	virus	virus	NN
cord-012418-6ralcn8p	498	26	.	.	.
cord-012418-6ralcn8p	499	1	Nevertheless	nevertheless	RB
cord-012418-6ralcn8p	499	2	,	,	,
cord-012418-6ralcn8p	499	3	the	the	DT
cord-012418-6ralcn8p	499	4	multitude	multitude	NN
cord-012418-6ralcn8p	499	5	of	of	IN
cord-012418-6ralcn8p	499	6	additional	additional	JJ
cord-012418-6ralcn8p	499	7	genes	gene	NNS
cord-012418-6ralcn8p	499	8	targeted	target	VBN
cord-012418-6ralcn8p	499	9	by	by	IN
cord-012418-6ralcn8p	499	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	499	11	signifies	signify	VBZ
cord-012418-6ralcn8p	499	12	that	that	IN
cord-012418-6ralcn8p	499	13	we	-PRON-	PRP
cord-012418-6ralcn8p	499	14	are	be	VBP
cord-012418-6ralcn8p	499	15	still	still	RB
cord-012418-6ralcn8p	499	16	just	just	RB
cord-012418-6ralcn8p	499	17	beginning	begin	VBG
cord-012418-6ralcn8p	499	18	to	to	TO
cord-012418-6ralcn8p	499	19	understand	understand	VB
cord-012418-6ralcn8p	499	20	the	the	DT
cord-012418-6ralcn8p	499	21	true	true	JJ
cord-012418-6ralcn8p	499	22	complexity	complexity	NN
cord-012418-6ralcn8p	499	23	of	of	IN
cord-012418-6ralcn8p	499	24	IRF3	IRF3	NNP
cord-012418-6ralcn8p	499	25	fine	fine	JJ
cord-012418-6ralcn8p	499	26	regulation	regulation	NN
cord-012418-6ralcn8p	499	27	.	.	.
cord-012418-6ralcn8p	500	1	In	in	IN
cord-012418-6ralcn8p	500	2	addition	addition	NN
cord-012418-6ralcn8p	500	3	to	to	IN
cord-012418-6ralcn8p	500	4	the	the	DT
cord-012418-6ralcn8p	500	5	ongoing	ongoing	JJ
cord-012418-6ralcn8p	500	6	characterisation	characterisation	NN
cord-012418-6ralcn8p	500	7	of	of	IN
cord-012418-6ralcn8p	500	8	the	the	DT
cord-012418-6ralcn8p	500	9	direct	direct	JJ
cord-012418-6ralcn8p	500	10	involvement	involvement	NN
cord-012418-6ralcn8p	500	11	in	in	IN
cord-012418-6ralcn8p	500	12	the	the	DT
cord-012418-6ralcn8p	500	13	expression	expression	NN
cord-012418-6ralcn8p	500	14	of	of	IN
cord-012418-6ralcn8p	500	15	ISGs	isg	NNS
cord-012418-6ralcn8p	500	16	,	,	,
cord-012418-6ralcn8p	500	17	powerful	powerful	JJ
cord-012418-6ralcn8p	500	18	in	in	IN
cord-012418-6ralcn8p	500	19	silico	silico	NN
cord-012418-6ralcn8p	500	20	and	and	CC
cord-012418-6ralcn8p	500	21	sequencing	sequencing	NN
cord-012418-6ralcn8p	500	22	approaches	approach	NNS
cord-012418-6ralcn8p	500	23	of	of	IN
cord-012418-6ralcn8p	500	24	recent	recent	JJ
cord-012418-6ralcn8p	500	25	years	year	NNS
cord-012418-6ralcn8p	500	26	revealed	reveal	VBD
cord-012418-6ralcn8p	500	27	a	a	DT
cord-012418-6ralcn8p	500	28	growing	grow	VBG
cord-012418-6ralcn8p	500	29	list	list	NN
cord-012418-6ralcn8p	500	30	of	of	IN
cord-012418-6ralcn8p	500	31	novel	novel	JJ
cord-012418-6ralcn8p	500	32	targets	target	NNS
cord-012418-6ralcn8p	500	33	,	,	,
cord-012418-6ralcn8p	500	34	including	include	VBG
cord-012418-6ralcn8p	500	35	virus	virus	NN
cord-012418-6ralcn8p	500	36	-	-	HYPH
cord-012418-6ralcn8p	500	37	inducible	inducible	JJ
cord-012418-6ralcn8p	500	38	RNAs	rna	NNS
cord-012418-6ralcn8p	500	39	[	[	-LRB-
cord-012418-6ralcn8p	500	40	107	107	CD
cord-012418-6ralcn8p	500	41	,	,	,
cord-012418-6ralcn8p	500	42	239	239	CD
cord-012418-6ralcn8p	500	43	]	]	-RRB-
cord-012418-6ralcn8p	500	44	.	.	.
cord-012418-6ralcn8p	501	1	Moreover	moreover	RB
cord-012418-6ralcn8p	501	2	,	,	,
cord-012418-6ralcn8p	501	3	some	some	DT
cord-012418-6ralcn8p	501	4	of	of	IN
cord-012418-6ralcn8p	501	5	the	the	DT
cord-012418-6ralcn8p	501	6	identified	identify	VBN
cord-012418-6ralcn8p	501	7	host	host	NN
cord-012418-6ralcn8p	501	8	modulators	modulator	NNS
cord-012418-6ralcn8p	501	9	hint	hint	VBP
cord-012418-6ralcn8p	501	10	at	at	IN
cord-012418-6ralcn8p	501	11	regulation	regulation	NN
cord-012418-6ralcn8p	501	12	of	of	IN
cord-012418-6ralcn8p	501	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	501	14	activity	activity	NN
cord-012418-6ralcn8p	501	15	dependent	dependent	JJ
cord-012418-6ralcn8p	501	16	on	on	IN
cord-012418-6ralcn8p	501	17	signalling	signal	VBG
cord-012418-6ralcn8p	501	18	of	of	IN
cord-012418-6ralcn8p	501	19	other	other	JJ
cord-012418-6ralcn8p	501	20	pathways	pathway	NNS
cord-012418-6ralcn8p	501	21	to	to	TO
cord-012418-6ralcn8p	501	22	enable	enable	VB
cord-012418-6ralcn8p	501	23	the	the	DT
cord-012418-6ralcn8p	501	24	incorporation	incorporation	NN
cord-012418-6ralcn8p	501	25	of	of	IN
cord-012418-6ralcn8p	501	26	further	further	JJ
cord-012418-6ralcn8p	501	27	Virus	virus	NN
cord-012418-6ralcn8p	501	28	interference	interference	NN
cord-012418-6ralcn8p	501	29	.	.	.
cord-012418-6ralcn8p	502	1	I.	I.	NNP
cord-012418-6ralcn8p	503	1	The	the	DT
cord-012418-6ralcn8p	503	2	interferon	interferon	NN
cord-012418-6ralcn8p	503	3	Global	global	JJ
cord-012418-6ralcn8p	503	4	virus	virus	NN
cord-012418-6ralcn8p	503	5	outbreaks	outbreak	NNS
cord-012418-6ralcn8p	503	6	:	:	:
cord-012418-6ralcn8p	503	7	Interferons	interferon	NNS
cord-012418-6ralcn8p	503	8	as	as	IN
cord-012418-6ralcn8p	504	1	1st	1st	JJ
cord-012418-6ralcn8p	504	2	responders	responder	NNS
cord-012418-6ralcn8p	504	3	Type	Type	NNP
cord-012418-6ralcn8p	504	4	I	-PRON-	PRP
cord-012418-6ralcn8p	504	5	Interferons	Interferons	NNPS
cord-012418-6ralcn8p	504	6	:	:	:
cord-012418-6ralcn8p	504	7	Distinct	Distinct	NNP
cord-012418-6ralcn8p	504	8	Biological	Biological	NNP
cord-012418-6ralcn8p	504	9	Activities	Activities	NNPS
cord-012418-6ralcn8p	504	10	and	and	CC
cord-012418-6ralcn8p	504	11	Current	Current	NNP
cord-012418-6ralcn8p	504	12	Applications	application	NNS
cord-012418-6ralcn8p	504	13	for	for	IN
cord-012418-6ralcn8p	504	14	Viral	viral	JJ
cord-012418-6ralcn8p	504	15	Infection	infection	NN
cord-012418-6ralcn8p	505	1	The	the	DT
cord-012418-6ralcn8p	505	2	Dual	Dual	NNP
cord-012418-6ralcn8p	505	3	Nature	Nature	NNP
cord-012418-6ralcn8p	505	4	of	of	IN
cord-012418-6ralcn8p	505	5	Type	Type	NNP
cord-012418-6ralcn8p	505	6	I	I	NNP
cord-012418-6ralcn8p	505	7	and	and	CC
cord-012418-6ralcn8p	505	8	Type	Type	NNP
cord-012418-6ralcn8p	505	9	II	II	NNP
cord-012418-6ralcn8p	505	10	Interferons	Interferons	NNPS
cord-012418-6ralcn8p	505	11	Shared	Shared	NNP
cord-012418-6ralcn8p	505	12	and	and	CC
cord-012418-6ralcn8p	505	13	Distinct	Distinct	NNP
cord-012418-6ralcn8p	505	14	Functions	Functions	NNPS
cord-012418-6ralcn8p	505	15	of	of	IN
cord-012418-6ralcn8p	505	16	Type	type	NN
cord-012418-6ralcn8p	505	17	I	I	NNP
cord-012418-6ralcn8p	505	18	and	and	CC
cord-012418-6ralcn8p	505	19	Type	Type	NNP
cord-012418-6ralcn8p	505	20	III	iii	CD
cord-012418-6ralcn8p	505	21	Interferons	Interferons	NNPS
cord-012418-6ralcn8p	506	1	Interferon	interferon	NN
cord-012418-6ralcn8p	506	2	-	-	HYPH
cord-012418-6ralcn8p	506	3	λ	λ	NNP
cord-012418-6ralcn8p	506	4	orchestrates	orchestrate	VBZ
cord-012418-6ralcn8p	506	5	innate	innate	JJ
cord-012418-6ralcn8p	506	6	and	and	CC
cord-012418-6ralcn8p	506	7	adaptive	adaptive	JJ
cord-012418-6ralcn8p	506	8	mucosal	mucosal	JJ
cord-012418-6ralcn8p	506	9	immune	immune	JJ
cord-012418-6ralcn8p	506	10	responses	response	NNS
cord-012418-6ralcn8p	506	11	Targeting	target	VBG
cord-012418-6ralcn8p	506	12	interferons	interferon	NNS
cord-012418-6ralcn8p	506	13	and	and	CC
cord-012418-6ralcn8p	506	14	their	-PRON-	PRP$
cord-012418-6ralcn8p	506	15	pathways	pathway	NNS
cord-012418-6ralcn8p	506	16	in	in	IN
cord-012418-6ralcn8p	506	17	systemic	systemic	JJ
cord-012418-6ralcn8p	506	18	lupus	lupus	NN
cord-012418-6ralcn8p	506	19	erythematosus	erythematosus	NN
cord-012418-6ralcn8p	506	20	Specificity	Specificity	NNP
cord-012418-6ralcn8p	506	21	and	and	CC
cord-012418-6ralcn8p	506	22	Function	Function	NNP
cord-012418-6ralcn8p	506	23	of	of	IN
cord-012418-6ralcn8p	506	24	IRF	IRF	NNP
cord-012418-6ralcn8p	506	25	Family	Family	NNP
cord-012418-6ralcn8p	506	26	Transcription	Transcription	NNP
cord-012418-6ralcn8p	506	27	Factors	Factors	NNPS
cord-012418-6ralcn8p	506	28	:	:	:
cord-012418-6ralcn8p	506	29	Insights	insight	NNS
cord-012418-6ralcn8p	506	30	from	from	IN
cord-012418-6ralcn8p	506	31	Genomics	genomic	NNS
cord-012418-6ralcn8p	507	1	Interferon	Interferon	NNP
cord-012418-6ralcn8p	507	2	Response	response	NN
cord-012418-6ralcn8p	507	3	of	of	IN
cord-012418-6ralcn8p	507	4	Chicken	Chicken	NNP
cord-012418-6ralcn8p	507	5	Embryo	Embryo	NNP
cord-012418-6ralcn8p	507	6	Fibroblasts	Fibroblasts	NNPS
cord-012418-6ralcn8p	507	7	to	to	IN
cord-012418-6ralcn8p	507	8	Nucleic	nucleic	JJ
cord-012418-6ralcn8p	507	9	Acids	acid	NNS
cord-012418-6ralcn8p	507	10	and	and	CC
cord-012418-6ralcn8p	508	1	Related	Related	NNP
cord-012418-6ralcn8p	508	2	Compounds	Compounds	NNPS
cord-012418-6ralcn8p	508	3	Inhibition	Inhibition	NNP
cord-012418-6ralcn8p	508	4	of	of	IN
cord-012418-6ralcn8p	508	5	virus	virus	NN
cord-012418-6ralcn8p	508	6	multiplication	multiplication	NN
cord-012418-6ralcn8p	508	7	by	by	IN
cord-012418-6ralcn8p	508	8	foreign	foreign	JJ
cord-012418-6ralcn8p	508	9	nucleic	nucleic	JJ
cord-012418-6ralcn8p	508	10	acid	acid	NN
cord-012418-6ralcn8p	508	11	Approaching	approach	VBG
cord-012418-6ralcn8p	508	12	the	the	DT
cord-012418-6ralcn8p	508	13	asymptote	asymptote	NN
cord-012418-6ralcn8p	508	14	?	?	.
cord-012418-6ralcn8p	509	1	Evolution	evolution	NN
cord-012418-6ralcn8p	509	2	and	and	CC
cord-012418-6ralcn8p	509	3	revolution	revolution	NN
cord-012418-6ralcn8p	509	4	in	in	IN
cord-012418-6ralcn8p	509	5	immunology	immunology	NN
cord-012418-6ralcn8p	509	6	Recognition	Recognition	NNP
cord-012418-6ralcn8p	509	7	of	of	IN
cord-012418-6ralcn8p	509	8	Endogenous	Endogenous	NNP
cord-012418-6ralcn8p	509	9	Nucleic	Nucleic	NNP
cord-012418-6ralcn8p	509	10	Acids	acid	NNS
cord-012418-6ralcn8p	509	11	by	by	IN
cord-012418-6ralcn8p	509	12	the	the	DT
cord-012418-6ralcn8p	509	13	Innate	Innate	NNP
cord-012418-6ralcn8p	509	14	Immune	Immune	NNP
cord-012418-6ralcn8p	509	15	System	System	NNP
cord-012418-6ralcn8p	509	16	Detection	Detection	NNP
cord-012418-6ralcn8p	509	17	of	of	IN
cord-012418-6ralcn8p	509	18	Microbial	microbial	JJ
cord-012418-6ralcn8p	509	19	Infections	Infections	NNPS
cord-012418-6ralcn8p	509	20	Through	through	IN
cord-012418-6ralcn8p	509	21	Innate	Innate	NNP
cord-012418-6ralcn8p	509	22	Immune	Immune	NNP
cord-012418-6ralcn8p	509	23	Sensing	sensing	NN
cord-012418-6ralcn8p	509	24	of	of	IN
cord-012418-6ralcn8p	509	25	Nucleic	nucleic	JJ
cord-012418-6ralcn8p	509	26	Acids	acid	NNS
cord-012418-6ralcn8p	509	27	Mechanisms	Mechanisms	NNPS
cord-012418-6ralcn8p	509	28	controlling	control	VBG
cord-012418-6ralcn8p	509	29	nucleic	nucleic	JJ
cord-012418-6ralcn8p	509	30	acid	acid	NN
cord-012418-6ralcn8p	509	31	-	-	HYPH
cord-012418-6ralcn8p	509	32	sensing	sense	VBG
cord-012418-6ralcn8p	509	33	Toll	toll	NN
cord-012418-6ralcn8p	509	34	-	-	HYPH
cord-012418-6ralcn8p	509	35	like	like	JJ
cord-012418-6ralcn8p	509	36	receptors	receptor	NNS
cord-012418-6ralcn8p	509	37	Molecular	molecular	JJ
cord-012418-6ralcn8p	509	38	basis	basis	NN
cord-012418-6ralcn8p	509	39	of	of	IN
cord-012418-6ralcn8p	509	40	NF	nf	NN
cord-012418-6ralcn8p	509	41	-	-	HYPH
cord-012418-6ralcn8p	509	42	κB	κB	NNP
cord-012418-6ralcn8p	509	43	signaling	signal	VBG
cord-012418-6ralcn8p	509	44	The	the	DT
cord-012418-6ralcn8p	509	45	regulation	regulation	NN
cord-012418-6ralcn8p	509	46	of	of	IN
cord-012418-6ralcn8p	509	47	AP-1	AP-1	NNP
cord-012418-6ralcn8p	509	48	activity	activity	NN
cord-012418-6ralcn8p	509	49	by	by	IN
cord-012418-6ralcn8p	509	50	mitogen	mitogen	NN
cord-012418-6ralcn8p	509	51	-	-	HYPH
cord-012418-6ralcn8p	509	52	activated	activate	VBN
cord-012418-6ralcn8p	509	53	protein	protein	NN
cord-012418-6ralcn8p	509	54	kinases	kinase	NNS
cord-012418-6ralcn8p	509	55	The	the	DT
cord-012418-6ralcn8p	509	56	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	509	57	code	code	NN
cord-012418-6ralcn8p	509	58	of	of	IN
cord-012418-6ralcn8p	509	59	human	human	JJ
cord-012418-6ralcn8p	509	60	IFN	IFN	NNP
cord-012418-6ralcn8p	509	61	-	-	HYPH
cord-012418-6ralcn8p	509	62	beta	beta	NN
cord-012418-6ralcn8p	509	63	gene	gene	NN
cord-012418-6ralcn8p	509	64	expression	expression	NN
cord-012418-6ralcn8p	509	65	Identification	identification	NN
cord-012418-6ralcn8p	509	66	of	of	IN
cord-012418-6ralcn8p	509	67	a	a	DT
cord-012418-6ralcn8p	509	68	member	member	NN
cord-012418-6ralcn8p	509	69	of	of	IN
cord-012418-6ralcn8p	509	70	the	the	DT
cord-012418-6ralcn8p	509	71	interferon	interferon	NN
cord-012418-6ralcn8p	509	72	regulatory	regulatory	JJ
cord-012418-6ralcn8p	509	73	factor	factor	NN
cord-012418-6ralcn8p	509	74	family	family	NN
cord-012418-6ralcn8p	509	75	that	that	WDT
cord-012418-6ralcn8p	509	76	binds	bind	VBZ
cord-012418-6ralcn8p	509	77	to	to	IN
cord-012418-6ralcn8p	509	78	the	the	DT
cord-012418-6ralcn8p	509	79	interferon	interferon	NN
cord-012418-6ralcn8p	509	80	-	-	HYPH
cord-012418-6ralcn8p	509	81	stimulated	stimulate	VBN
cord-012418-6ralcn8p	509	82	response	response	NN
cord-012418-6ralcn8p	509	83	element	element	NN
cord-012418-6ralcn8p	509	84	and	and	CC
cord-012418-6ralcn8p	509	85	activates	activate	VBZ
cord-012418-6ralcn8p	509	86	expression	expression	NN
cord-012418-6ralcn8p	509	87	of	of	IN
cord-012418-6ralcn8p	509	88	interferon	interferon	NN
cord-012418-6ralcn8p	509	89	-	-	HYPH
cord-012418-6ralcn8p	509	90	induced	induce	VBN
cord-012418-6ralcn8p	509	91	genes	gene	NNS
cord-012418-6ralcn8p	509	92	Structural	structural	JJ
cord-012418-6ralcn8p	509	93	and	and	CC
cord-012418-6ralcn8p	509	94	functional	functional	JJ
cord-012418-6ralcn8p	509	95	analysis	analysis	NN
cord-012418-6ralcn8p	509	96	of	of	IN
cord-012418-6ralcn8p	509	97	interferon	interferon	NN
cord-012418-6ralcn8p	509	98	regulatory	regulatory	JJ
cord-012418-6ralcn8p	509	99	factor	factor	NN
cord-012418-6ralcn8p	509	100	3	3	CD
cord-012418-6ralcn8p	509	101	:	:	:
cord-012418-6ralcn8p	510	1	Localization	localization	NN
cord-012418-6ralcn8p	510	2	of	of	IN
cord-012418-6ralcn8p	510	3	the	the	DT
cord-012418-6ralcn8p	510	4	transactivation	transactivation	NN
cord-012418-6ralcn8p	510	5	and	and	CC
cord-012418-6ralcn8p	510	6	autoinhibitory	autoinhibitory	JJ
cord-012418-6ralcn8p	510	7	domains	domain	NNS
cord-012418-6ralcn8p	510	8	Crystal	Crystal	NNP
cord-012418-6ralcn8p	510	9	structure	structure	NN
cord-012418-6ralcn8p	510	10	of	of	IN
cord-012418-6ralcn8p	510	11	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	510	12	reveals	reveal	VBZ
cord-012418-6ralcn8p	510	13	mechanism	mechanism	NN
cord-012418-6ralcn8p	510	14	of	of	IN
cord-012418-6ralcn8p	510	15	autoinhibition	autoinhibition	NN
cord-012418-6ralcn8p	510	16	and	and	CC
cord-012418-6ralcn8p	510	17	virus	virus	NN
cord-012418-6ralcn8p	510	18	-	-	HYPH
cord-012418-6ralcn8p	510	19	induced	induce	VBN
cord-012418-6ralcn8p	510	20	phosphoactivation	phosphoactivation	NN
cord-012418-6ralcn8p	510	21	Direct	direct	JJ
cord-012418-6ralcn8p	510	22	triggering	triggering	NN
cord-012418-6ralcn8p	510	23	of	of	IN
cord-012418-6ralcn8p	510	24	the	the	DT
cord-012418-6ralcn8p	510	25	type	type	NN
cord-012418-6ralcn8p	511	1	I	-PRON-	PRP
cord-012418-6ralcn8p	511	2	interferon	interferon	VBD
cord-012418-6ralcn8p	511	3	system	system	NN
cord-012418-6ralcn8p	511	4	by	by	IN
cord-012418-6ralcn8p	511	5	virus	virus	NN
cord-012418-6ralcn8p	511	6	infection	infection	NN
cord-012418-6ralcn8p	511	7	:	:	:
cord-012418-6ralcn8p	511	8	Activation	activation	NN
cord-012418-6ralcn8p	511	9	of	of	IN
cord-012418-6ralcn8p	511	10	a	a	DT
cord-012418-6ralcn8p	511	11	transcription	transcription	NN
cord-012418-6ralcn8p	511	12	factor	factor	NN
cord-012418-6ralcn8p	511	13	complex	complex	NN
cord-012418-6ralcn8p	511	14	containing	contain	VBG
cord-012418-6ralcn8p	511	15	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	511	16	and	and	CC
cord-012418-6ralcn8p	511	17	CBP	CBP	NNP
cord-012418-6ralcn8p	511	18	/	/	SYM
cord-012418-6ralcn8p	511	19	p300	p300	NNP
cord-012418-6ralcn8p	511	20	Regulated	Regulated	NNP
cord-012418-6ralcn8p	511	21	nuclear	nuclear	JJ
cord-012418-6ralcn8p	511	22	-	-	HYPH
cord-012418-6ralcn8p	511	23	cytoplasmic	cytoplasmic	JJ
cord-012418-6ralcn8p	511	24	localization	localization	NN
cord-012418-6ralcn8p	511	25	of	of	IN
cord-012418-6ralcn8p	511	26	interferon	interferon	NN
cord-012418-6ralcn8p	511	27	regulatory	regulatory	JJ
cord-012418-6ralcn8p	511	28	factor	factor	NN
cord-012418-6ralcn8p	511	29	3	3	CD
cord-012418-6ralcn8p	511	30	,	,	,
cord-012418-6ralcn8p	511	31	a	a	DT
cord-012418-6ralcn8p	511	32	subunit	subunit	NN
cord-012418-6ralcn8p	511	33	of	of	IN
cord-012418-6ralcn8p	511	34	double	double	RB
cord-012418-6ralcn8p	511	35	-	-	HYPH
cord-012418-6ralcn8p	511	36	stranded	strand	VBN
cord-012418-6ralcn8p	511	37	RNA	RNA	NNP
cord-012418-6ralcn8p	511	38	-	-	HYPH
cord-012418-6ralcn8p	511	39	activated	activate	VBN
cord-012418-6ralcn8p	511	40	factor	factor	NN
cord-012418-6ralcn8p	511	41	1	1	CD
cord-012418-6ralcn8p	511	42	Bipartite	Bipartite	NNP
cord-012418-6ralcn8p	511	43	Nuclear	Nuclear	NNP
cord-012418-6ralcn8p	511	44	Localization	Localization	NNP
cord-012418-6ralcn8p	511	45	Signal	Signal	NNP
cord-012418-6ralcn8p	511	46	Controls	Controls	NNP
cord-012418-6ralcn8p	511	47	Nuclear	Nuclear	NNP
cord-012418-6ralcn8p	511	48	Import	Import	NNP
cord-012418-6ralcn8p	511	49	and	and	CC
cord-012418-6ralcn8p	511	50	DNA	DNA	NNP
cord-012418-6ralcn8p	511	51	-	-	HYPH
cord-012418-6ralcn8p	511	52	Binding	Binding	NNP
cord-012418-6ralcn8p	511	53	Activity	activity	NN
cord-012418-6ralcn8p	511	54	of	of	IN
cord-012418-6ralcn8p	511	55	IFN	IFN	NNP
cord-012418-6ralcn8p	511	56	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	511	57	Factor	Factor	NNP
cord-012418-6ralcn8p	511	58	3	3	CD
cord-012418-6ralcn8p	511	59	Analysis	Analysis	NNP
cord-012418-6ralcn8p	511	60	of	of	IN
cord-012418-6ralcn8p	511	61	functional	functional	JJ
cord-012418-6ralcn8p	511	62	domains	domain	NNS
cord-012418-6ralcn8p	511	63	of	of	IN
cord-012418-6ralcn8p	511	64	interferon	interferon	NN
cord-012418-6ralcn8p	511	65	regulatory	regulatory	JJ
cord-012418-6ralcn8p	511	66	factor	factor	NN
cord-012418-6ralcn8p	511	67	7	7	CD
cord-012418-6ralcn8p	511	68	and	and	CC
cord-012418-6ralcn8p	511	69	its	-PRON-	PRP$
cord-012418-6ralcn8p	511	70	association	association	NN
cord-012418-6ralcn8p	511	71	with	with	IN
cord-012418-6ralcn8p	511	72	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	511	73	Gene	Gene	NNP
cord-012418-6ralcn8p	511	74	induction	induction	NN
cord-012418-6ralcn8p	511	75	pathways	pathway	NNS
cord-012418-6ralcn8p	511	76	mediated	mediate	VBN
cord-012418-6ralcn8p	511	77	by	by	IN
cord-012418-6ralcn8p	511	78	distinct	distinct	JJ
cord-012418-6ralcn8p	511	79	IRFs	irfs	NN
cord-012418-6ralcn8p	511	80	during	during	IN
cord-012418-6ralcn8p	511	81	viral	viral	JJ
cord-012418-6ralcn8p	511	82	infection	infection	NN
cord-012418-6ralcn8p	512	1	Structural	structural	JJ
cord-012418-6ralcn8p	512	2	insights	insight	NNS
cord-012418-6ralcn8p	512	3	into	into	IN
cord-012418-6ralcn8p	512	4	interferon	interferon	NN
cord-012418-6ralcn8p	512	5	regulatory	regulatory	JJ
cord-012418-6ralcn8p	512	6	factor	factor	NN
cord-012418-6ralcn8p	512	7	activation	activation	NN
cord-012418-6ralcn8p	513	1	IRF-7	IRF-7	NNP
cord-012418-6ralcn8p	513	2	is	be	VBZ
cord-012418-6ralcn8p	513	3	the	the	DT
cord-012418-6ralcn8p	513	4	master	master	NN
cord-012418-6ralcn8p	513	5	regulator	regulator	NN
cord-012418-6ralcn8p	513	6	of	of	IN
cord-012418-6ralcn8p	513	7	type	type	NN
cord-012418-6ralcn8p	513	8	-	-	:
cord-012418-6ralcn8p	513	9	I	-PRON-	PRP
cord-012418-6ralcn8p	513	10	interferon	interferon	NN
cord-012418-6ralcn8p	513	11	-	-	HYPH
cord-012418-6ralcn8p	513	12	dependent	dependent	JJ
cord-012418-6ralcn8p	513	13	immune	immune	JJ
cord-012418-6ralcn8p	513	14	responses	response	NNS
cord-012418-6ralcn8p	514	1	IRF7	IRF7	NNP
cord-012418-6ralcn8p	514	2	:	:	:
cord-012418-6ralcn8p	514	3	Activation	activation	NN
cord-012418-6ralcn8p	514	4	,	,	,
cord-012418-6ralcn8p	514	5	regulation	regulation	NN
cord-012418-6ralcn8p	514	6	,	,	,
cord-012418-6ralcn8p	514	7	modification	modification	NN
cord-012418-6ralcn8p	514	8	and	and	CC
cord-012418-6ralcn8p	514	9	function	function	NN
cord-012418-6ralcn8p	515	1	The	the	DT
cord-012418-6ralcn8p	515	2	multifaceted	multifaceted	JJ
cord-012418-6ralcn8p	515	3	biology	biology	NN
cord-012418-6ralcn8p	515	4	of	of	IN
cord-012418-6ralcn8p	515	5	plasmacytoid	plasmacytoid	NN
cord-012418-6ralcn8p	515	6	dendritic	dendritic	JJ
cord-012418-6ralcn8p	515	7	Cells	Cells	NNP
cord-012418-6ralcn8p	515	8	Characterization	characterization	NN
cord-012418-6ralcn8p	515	9	of	of	IN
cord-012418-6ralcn8p	515	10	the	the	DT
cord-012418-6ralcn8p	515	11	Interferon	Interferon	NNP
cord-012418-6ralcn8p	515	12	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	515	13	Factor-7	Factor-7	NNPS
cord-012418-6ralcn8p	515	14	and	and	CC
cord-012418-6ralcn8p	515	15	Its	-PRON-	PRP$
cord-012418-6ralcn8p	515	16	Potential	potential	JJ
cord-012418-6ralcn8p	515	17	Role	role	NN
cord-012418-6ralcn8p	515	18	in	in	IN
cord-012418-6ralcn8p	515	19	the	the	DT
cord-012418-6ralcn8p	515	20	Transcription	Transcription	NNP
cord-012418-6ralcn8p	515	21	Activation	Activation	NNP
cord-012418-6ralcn8p	515	22	of	of	IN
cord-012418-6ralcn8p	515	23	Interferon	Interferon	NNP
cord-012418-6ralcn8p	515	24	A	A	NNP
cord-012418-6ralcn8p	515	25	Genes	Genes	NNPS
cord-012418-6ralcn8p	515	26	Positive	positive	JJ
cord-012418-6ralcn8p	515	27	feedback	feedback	NN
cord-012418-6ralcn8p	515	28	regulation	regulation	NN
cord-012418-6ralcn8p	515	29	of	of	IN
cord-012418-6ralcn8p	515	30	type	type	NN
cord-012418-6ralcn8p	516	1	I	-PRON-	PRP
cord-012418-6ralcn8p	516	2	IFN	IFN	NNP
cord-012418-6ralcn8p	516	3	genes	gene	NNS
cord-012418-6ralcn8p	516	4	by	by	IN
cord-012418-6ralcn8p	516	5	the	the	DT
cord-012418-6ralcn8p	516	6	IFN	IFN	NNP
cord-012418-6ralcn8p	516	7	-	-	HYPH
cord-012418-6ralcn8p	516	8	inducible	inducible	JJ
cord-012418-6ralcn8p	516	9	transcription	transcription	NN
cord-012418-6ralcn8p	516	10	factor	factor	NN
cord-012418-6ralcn8p	516	11	IRF-7	IRF-7	NNP
cord-012418-6ralcn8p	516	12	Differential	differential	JJ
cord-012418-6ralcn8p	516	13	viral	viral	JJ
cord-012418-6ralcn8p	516	14	induction	induction	NN
cord-012418-6ralcn8p	516	15	of	of	IN
cord-012418-6ralcn8p	516	16	distinct	distinct	JJ
cord-012418-6ralcn8p	516	17	interferon	interferon	NN
cord-012418-6ralcn8p	516	18	-	-	HYPH
cord-012418-6ralcn8p	516	19	alpha	alpha	NN
cord-012418-6ralcn8p	516	20	genes	gene	NNS
cord-012418-6ralcn8p	516	21	by	by	IN
cord-012418-6ralcn8p	516	22	positive	positive	JJ
cord-012418-6ralcn8p	516	23	feedback	feedback	NN
cord-012418-6ralcn8p	516	24	through	through	IN
cord-012418-6ralcn8p	516	25	interferon	interferon	NN
cord-012418-6ralcn8p	516	26	regulatory	regulatory	JJ
cord-012418-6ralcn8p	516	27	factor-7	factor-7	NNS
cord-012418-6ralcn8p	517	1	Selective	selective	JJ
cord-012418-6ralcn8p	517	2	DNA	dna	NN
cord-012418-6ralcn8p	517	3	binding	binding	NN
cord-012418-6ralcn8p	517	4	and	and	CC
cord-012418-6ralcn8p	517	5	association	association	NN
cord-012418-6ralcn8p	517	6	with	with	IN
cord-012418-6ralcn8p	517	7	the	the	DT
cord-012418-6ralcn8p	517	8	CREB	CREB	NNP
cord-012418-6ralcn8p	517	9	binding	bind	VBG
cord-012418-6ralcn8p	517	10	protein	protein	NN
cord-012418-6ralcn8p	518	1	coactivator	coactivator	NNP
cord-012418-6ralcn8p	518	2	contribute	contribute	VB
cord-012418-6ralcn8p	518	3	to	to	IN
cord-012418-6ralcn8p	518	4	differential	differential	JJ
cord-012418-6ralcn8p	518	5	activation	activation	NN
cord-012418-6ralcn8p	518	6	of	of	IN
cord-012418-6ralcn8p	518	7	alpha	alpha	NN
cord-012418-6ralcn8p	518	8	/	/	SYM
cord-012418-6ralcn8p	518	9	beta	beta	NN
cord-012418-6ralcn8p	518	10	interferon	interferon	NN
cord-012418-6ralcn8p	518	11	genes	gene	NNS
cord-012418-6ralcn8p	518	12	by	by	IN
cord-012418-6ralcn8p	518	13	interferon	interferon	NN
cord-012418-6ralcn8p	518	14	regulatory	regulatory	JJ
cord-012418-6ralcn8p	518	15	factors	factor	NNS
cord-012418-6ralcn8p	518	16	3	3	CD
cord-012418-6ralcn8p	518	17	and	and	CC
cord-012418-6ralcn8p	518	18	7	7	CD
cord-012418-6ralcn8p	518	19	Distinct	distinct	JJ
cord-012418-6ralcn8p	518	20	and	and	CC
cord-012418-6ralcn8p	518	21	essential	essential	JJ
cord-012418-6ralcn8p	518	22	roles	role	NNS
cord-012418-6ralcn8p	518	23	of	of	IN
cord-012418-6ralcn8p	518	24	transcription	transcription	NN
cord-012418-6ralcn8p	518	25	factors	factor	NNS
cord-012418-6ralcn8p	518	26	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	518	27	and	and	CC
cord-012418-6ralcn8p	518	28	IRF-7	IRF-7	NNP
cord-012418-6ralcn8p	518	29	in	in	IN
cord-012418-6ralcn8p	518	30	response	response	NN
cord-012418-6ralcn8p	518	31	to	to	IN
cord-012418-6ralcn8p	518	32	viruses	virus	NNS
cord-012418-6ralcn8p	518	33	for	for	IN
cord-012418-6ralcn8p	518	34	IFN	IFN	NNP
cord-012418-6ralcn8p	518	35	-	-	HYPH
cord-012418-6ralcn8p	518	36	alpha	alpha	NN
cord-012418-6ralcn8p	518	37	/	/	SYM
cord-012418-6ralcn8p	518	38	beta	beta	NN
cord-012418-6ralcn8p	518	39	gene	gene	NN
cord-012418-6ralcn8p	518	40	induction	induction	NN
cord-012418-6ralcn8p	519	1	A	a	DT
cord-012418-6ralcn8p	519	2	Positive	positive	JJ
cord-012418-6ralcn8p	519	3	Feedback	feedback	NN
cord-012418-6ralcn8p	519	4	Amplifier	Amplifier	NNP
cord-012418-6ralcn8p	519	5	Circuit	Circuit	NNP
cord-012418-6ralcn8p	519	6	That	that	WDT
cord-012418-6ralcn8p	519	7	Regulates	regulate	VBZ
cord-012418-6ralcn8p	519	8	Interferon	Interferon	NNP
cord-012418-6ralcn8p	519	9	(	(	-LRB-
cord-012418-6ralcn8p	519	10	IFN)-Stimulated	IFN)-Stimulated	NNP
cord-012418-6ralcn8p	519	11	Gene	Gene	NNP
cord-012418-6ralcn8p	519	12	Expression	Expression	NNP
cord-012418-6ralcn8p	519	13	and	and	CC
cord-012418-6ralcn8p	519	14	Controls	Controls	NNP
cord-012418-6ralcn8p	519	15	Type	Type	NNP
cord-012418-6ralcn8p	519	16	I	I	NNP
cord-012418-6ralcn8p	519	17	and	and	CC
cord-012418-6ralcn8p	519	18	Type	Type	NNP
cord-012418-6ralcn8p	519	19	II	II	NNP
cord-012418-6ralcn8p	520	1	IFN	IFN	NNP
cord-012418-6ralcn8p	520	2	Responses	Responses	NNPS
cord-012418-6ralcn8p	520	3	Involvement	Involvement	NNP
cord-012418-6ralcn8p	520	4	of	of	IN
cord-012418-6ralcn8p	520	5	the	the	DT
cord-012418-6ralcn8p	520	6	IRF	IRF	NNP
cord-012418-6ralcn8p	520	7	family	family	NN
cord-012418-6ralcn8p	520	8	transcription	transcription	NN
cord-012418-6ralcn8p	520	9	factor	factor	NN
cord-012418-6ralcn8p	520	10	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	520	11	in	in	IN
cord-012418-6ralcn8p	520	12	virus	virus	NN
cord-012418-6ralcn8p	520	13	-	-	HYPH
cord-012418-6ralcn8p	520	14	induced	induce	VBN
cord-012418-6ralcn8p	520	15	activation	activation	NN
cord-012418-6ralcn8p	520	16	of	of	IN
cord-012418-6ralcn8p	520	17	the	the	DT
cord-012418-6ralcn8p	520	18	IFN	IFN	NNP
cord-012418-6ralcn8p	520	19	-	-	HYPH
cord-012418-6ralcn8p	520	20	beta	beta	NN
cord-012418-6ralcn8p	520	21	gene	gene	NN
cord-012418-6ralcn8p	520	22	Virus	virus	NN
cord-012418-6ralcn8p	520	23	-	-	HYPH
cord-012418-6ralcn8p	520	24	dependent	dependent	JJ
cord-012418-6ralcn8p	520	25	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	520	26	of	of	IN
cord-012418-6ralcn8p	520	27	the	the	DT
cord-012418-6ralcn8p	520	28	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	520	29	transcription	transcription	NN
cord-012418-6ralcn8p	520	30	factor	factor	NN
cord-012418-6ralcn8p	520	31	regulates	regulate	VBZ
cord-012418-6ralcn8p	520	32	nuclear	nuclear	JJ
cord-012418-6ralcn8p	520	33	translocation	translocation	NN
cord-012418-6ralcn8p	520	34	,	,	,
cord-012418-6ralcn8p	520	35	transactivation	transactivation	NN
cord-012418-6ralcn8p	520	36	potential	potential	NN
cord-012418-6ralcn8p	520	37	,	,	,
cord-012418-6ralcn8p	520	38	and	and	CC
cord-012418-6ralcn8p	520	39	proteasome	proteasome	VBN
cord-012418-6ralcn8p	520	40	-	-	HYPH
cord-012418-6ralcn8p	520	41	mediated	mediate	VBN
cord-012418-6ralcn8p	520	42	degradation	degradation	NN
cord-012418-6ralcn8p	520	43	Virus	virus	NN
cord-012418-6ralcn8p	520	44	infection	infection	NN
cord-012418-6ralcn8p	520	45	induces	induce	VBZ
cord-012418-6ralcn8p	520	46	the	the	DT
cord-012418-6ralcn8p	520	47	assembly	assembly	NN
cord-012418-6ralcn8p	520	48	of	of	IN
cord-012418-6ralcn8p	520	49	coordinately	coordinately	NNP
cord-012418-6ralcn8p	520	50	activated	activate	VBD
cord-012418-6ralcn8p	520	51	transcription	transcription	NN
cord-012418-6ralcn8p	520	52	factors	factor	NNS
cord-012418-6ralcn8p	520	53	on	on	IN
cord-012418-6ralcn8p	520	54	the	the	DT
cord-012418-6ralcn8p	520	55	IFN	IFN	NNP
cord-012418-6ralcn8p	520	56	-	-	HYPH
cord-012418-6ralcn8p	520	57	beta	beta	NN
cord-012418-6ralcn8p	520	58	enhancer	enhancer	NN
cord-012418-6ralcn8p	520	59	in	in	IN
cord-012418-6ralcn8p	520	60	vivo	vivo	NNP
cord-012418-6ralcn8p	520	61	Identification	identification	NN
cord-012418-6ralcn8p	520	62	of	of	IN
cord-012418-6ralcn8p	520	63	distinct	distinct	JJ
cord-012418-6ralcn8p	520	64	signaling	signal	VBG
cord-012418-6ralcn8p	520	65	pathways	pathway	NNS
cord-012418-6ralcn8p	520	66	leading	lead	VBG
cord-012418-6ralcn8p	520	67	to	to	IN
cord-012418-6ralcn8p	520	68	the	the	DT
cord-012418-6ralcn8p	520	69	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	520	70	of	of	IN
cord-012418-6ralcn8p	520	71	interferon	interferon	NN
cord-012418-6ralcn8p	520	72	regulatory	regulatory	JJ
cord-012418-6ralcn8p	520	73	factor	factor	NN
cord-012418-6ralcn8p	520	74	3	3	CD
cord-012418-6ralcn8p	520	75	STING	sting	NN
cord-012418-6ralcn8p	520	76	specifies	specify	VBZ
cord-012418-6ralcn8p	520	77	IRF3	IRF3	NNP
cord-012418-6ralcn8p	520	78	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	520	79	by	by	IN
cord-012418-6ralcn8p	520	80	TBK1	TBK1	NNP
cord-012418-6ralcn8p	520	81	in	in	IN
cord-012418-6ralcn8p	520	82	the	the	DT
cord-012418-6ralcn8p	520	83	cytosolic	cytosolic	JJ
cord-012418-6ralcn8p	520	84	DNA	dna	NN
cord-012418-6ralcn8p	520	85	signaling	signal	VBG
cord-012418-6ralcn8p	520	86	pathway	pathway	NN
cord-012418-6ralcn8p	520	87	Phosphorylation	Phosphorylation	NNP
cord-012418-6ralcn8p	520	88	of	of	IN
cord-012418-6ralcn8p	520	89	innate	innate	JJ
cord-012418-6ralcn8p	520	90	immune	immune	JJ
cord-012418-6ralcn8p	520	91	adaptor	adaptor	NN
cord-012418-6ralcn8p	520	92	proteins	protein	NNS
cord-012418-6ralcn8p	520	93	MAVS	mavs	RB
cord-012418-6ralcn8p	520	94	,	,	,
cord-012418-6ralcn8p	520	95	STING	sting	NN
cord-012418-6ralcn8p	520	96	,	,	,
cord-012418-6ralcn8p	520	97	and	and	CC
cord-012418-6ralcn8p	520	98	TRIF	TRIF	NNP
cord-012418-6ralcn8p	520	99	induces	induce	VBZ
cord-012418-6ralcn8p	520	100	IRF3	IRF3	NNP
cord-012418-6ralcn8p	520	101	activation	activation	NN
cord-012418-6ralcn8p	520	102	Structural	structural	JJ
cord-012418-6ralcn8p	520	103	basis	basis	NN
cord-012418-6ralcn8p	520	104	for	for	IN
cord-012418-6ralcn8p	520	105	concerted	concerted	JJ
cord-012418-6ralcn8p	520	106	recruitment	recruitment	NN
cord-012418-6ralcn8p	520	107	and	and	CC
cord-012418-6ralcn8p	520	108	activation	activation	NN
cord-012418-6ralcn8p	520	109	of	of	IN
cord-012418-6ralcn8p	520	110	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	520	111	by	by	IN
cord-012418-6ralcn8p	520	112	innate	innate	JJ
cord-012418-6ralcn8p	520	113	immune	immune	JJ
cord-012418-6ralcn8p	520	114	adaptor	adaptor	NN
cord-012418-6ralcn8p	520	115	proteins	protein	NNS
cord-012418-6ralcn8p	521	1	IKKepsilon	IKKepsilon	NNP
cord-012418-6ralcn8p	521	2	and	and	CC
cord-012418-6ralcn8p	521	3	TBK1	TBK1	NNP
cord-012418-6ralcn8p	521	4	are	be	VBP
cord-012418-6ralcn8p	521	5	essential	essential	JJ
cord-012418-6ralcn8p	521	6	components	component	NNS
cord-012418-6ralcn8p	521	7	of	of	IN
cord-012418-6ralcn8p	521	8	the	the	DT
cord-012418-6ralcn8p	521	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	521	10	signaling	signal	VBG
cord-012418-6ralcn8p	521	11	pathway	pathway	NN
cord-012418-6ralcn8p	521	12	Triggering	trigger	VBG
cord-012418-6ralcn8p	521	13	the	the	DT
cord-012418-6ralcn8p	521	14	interferon	interferon	NN
cord-012418-6ralcn8p	521	15	antiviral	antiviral	JJ
cord-012418-6ralcn8p	521	16	response	response	NN
cord-012418-6ralcn8p	521	17	through	through	IN
cord-012418-6ralcn8p	521	18	an	an	DT
cord-012418-6ralcn8p	521	19	IKK	IKK	NNP
cord-012418-6ralcn8p	521	20	-	-	HYPH
cord-012418-6ralcn8p	521	21	related	relate	VBN
cord-012418-6ralcn8p	521	22	pathway	pathway	NN
cord-012418-6ralcn8p	521	23	Interferon	Interferon	NNP
cord-012418-6ralcn8p	521	24	regulatory	regulatory	JJ
cord-012418-6ralcn8p	521	25	factor	factor	NN
cord-012418-6ralcn8p	521	26	3	3	CD
cord-012418-6ralcn8p	521	27	is	be	VBZ
cord-012418-6ralcn8p	521	28	regulated	regulate	VBN
cord-012418-6ralcn8p	521	29	by	by	IN
cord-012418-6ralcn8p	521	30	a	a	DT
cord-012418-6ralcn8p	521	31	dual	dual	JJ
cord-012418-6ralcn8p	521	32	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	521	33	-	-	HYPH
cord-012418-6ralcn8p	521	34	dependent	dependent	JJ
cord-012418-6ralcn8p	521	35	switch	switch	NN
cord-012418-6ralcn8p	521	36	Crystal	Crystal	NNP
cord-012418-6ralcn8p	521	37	structure	structure	NN
cord-012418-6ralcn8p	521	38	of	of	IN
cord-012418-6ralcn8p	521	39	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	521	40	in	in	IN
cord-012418-6ralcn8p	521	41	complex	complex	NN
cord-012418-6ralcn8p	521	42	with	with	IN
cord-012418-6ralcn8p	521	43	CBP	CBP	NNP
cord-012418-6ralcn8p	521	44	Identification	Identification	NNP
cord-012418-6ralcn8p	521	45	of	of	IN
cord-012418-6ralcn8p	521	46	the	the	DT
cord-012418-6ralcn8p	521	47	minimal	minimal	JJ
cord-012418-6ralcn8p	521	48	phosphoacceptor	phosphoacceptor	NN
cord-012418-6ralcn8p	521	49	site	site	NN
cord-012418-6ralcn8p	521	50	required	require	VBN
cord-012418-6ralcn8p	521	51	for	for	IN
cord-012418-6ralcn8p	521	52	in	in	IN
cord-012418-6ralcn8p	521	53	vivo	vivo	NN
cord-012418-6ralcn8p	521	54	activation	activation	NN
cord-012418-6ralcn8p	521	55	of	of	IN
cord-012418-6ralcn8p	521	56	interferon	interferon	NN
cord-012418-6ralcn8p	521	57	regulatory	regulatory	JJ
cord-012418-6ralcn8p	521	58	factor	factor	NN
cord-012418-6ralcn8p	521	59	3	3	CD
cord-012418-6ralcn8p	521	60	in	in	IN
cord-012418-6ralcn8p	521	61	response	response	NN
cord-012418-6ralcn8p	521	62	to	to	IN
cord-012418-6ralcn8p	521	63	virus	virus	NN
cord-012418-6ralcn8p	521	64	and	and	CC
cord-012418-6ralcn8p	521	65	double	double	RB
cord-012418-6ralcn8p	521	66	-	-	HYPH
cord-012418-6ralcn8p	521	67	stranded	strand	VBN
cord-012418-6ralcn8p	521	68	RNA	RNA	NNP
cord-012418-6ralcn8p	521	69	Phosphorylation	Phosphorylation	NNP
cord-012418-6ralcn8p	521	70	of	of	IN
cord-012418-6ralcn8p	521	71	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	521	72	on	on	IN
cord-012418-6ralcn8p	521	73	Ser	Ser	NNP
cord-012418-6ralcn8p	521	74	339	339	CD
cord-012418-6ralcn8p	521	75	generates	generate	VBZ
cord-012418-6ralcn8p	521	76	a	a	DT
cord-012418-6ralcn8p	521	77	hyperactive	hyperactive	JJ
cord-012418-6ralcn8p	521	78	form	form	NN
cord-012418-6ralcn8p	521	79	of	of	IN
cord-012418-6ralcn8p	521	80	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	521	81	through	through	IN
cord-012418-6ralcn8p	521	82	regulation	regulation	NN
cord-012418-6ralcn8p	521	83	of	of	IN
cord-012418-6ralcn8p	521	84	dimerization	dimerization	NN
cord-012418-6ralcn8p	521	85	and	and	CC
cord-012418-6ralcn8p	521	86	CBP	CBP	NNP
cord-012418-6ralcn8p	521	87	association	association	NNP
cord-012418-6ralcn8p	522	1	Ser386	ser386	CD
cord-012418-6ralcn8p	522	2	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	522	3	of	of	IN
cord-012418-6ralcn8p	522	4	transcription	transcription	NN
cord-012418-6ralcn8p	522	5	factor	factor	NN
cord-012418-6ralcn8p	523	1	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	523	2	induces	induce	VBZ
cord-012418-6ralcn8p	523	3	dimerization	dimerization	NN
cord-012418-6ralcn8p	523	4	and	and	CC
cord-012418-6ralcn8p	523	5	association	association	NN
cord-012418-6ralcn8p	523	6	with	with	IN
cord-012418-6ralcn8p	523	7	CBP	CBP	NNP
cord-012418-6ralcn8p	523	8	/	/	SYM
cord-012418-6ralcn8p	523	9	p300	p300	NN
cord-012418-6ralcn8p	523	10	without	without	IN
cord-012418-6ralcn8p	523	11	overall	overall	JJ
cord-012418-6ralcn8p	523	12	conformational	conformational	JJ
cord-012418-6ralcn8p	523	13	change	change	NN
cord-012418-6ralcn8p	523	14	Identification	identification	NN
cord-012418-6ralcn8p	523	15	of	of	IN
cord-012418-6ralcn8p	523	16	Ser-386	ser-386	CD
cord-012418-6ralcn8p	523	17	of	of	IN
cord-012418-6ralcn8p	523	18	interferon	interferon	NN
cord-012418-6ralcn8p	523	19	regulatory	regulatory	JJ
cord-012418-6ralcn8p	523	20	factor	factor	NN
cord-012418-6ralcn8p	523	21	3	3	CD
cord-012418-6ralcn8p	523	22	as	as	IN
cord-012418-6ralcn8p	523	23	critical	critical	JJ
cord-012418-6ralcn8p	523	24	target	target	NN
cord-012418-6ralcn8p	523	25	for	for	IN
cord-012418-6ralcn8p	523	26	inducible	inducible	JJ
cord-012418-6ralcn8p	523	27	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	523	28	that	that	WDT
cord-012418-6ralcn8p	523	29	determines	determine	VBZ
cord-012418-6ralcn8p	523	30	activation	activation	NN
cord-012418-6ralcn8p	523	31	Contribution	Contribution	NNP
cord-012418-6ralcn8p	523	32	of	of	IN
cord-012418-6ralcn8p	523	33	Ser386	ser386	CD
cord-012418-6ralcn8p	523	34	and	and	CC
cord-012418-6ralcn8p	523	35	Ser396	ser396	CD
cord-012418-6ralcn8p	523	36	to	to	TO
cord-012418-6ralcn8p	523	37	activation	activation	VB
cord-012418-6ralcn8p	523	38	of	of	IN
cord-012418-6ralcn8p	523	39	interferon	interferon	NN
cord-012418-6ralcn8p	523	40	regulatory	regulatory	JJ
cord-012418-6ralcn8p	523	41	factor	factor	NN
cord-012418-6ralcn8p	523	42	3	3	CD
cord-012418-6ralcn8p	523	43	Interferon	Interferon	NNP
cord-012418-6ralcn8p	523	44	regulatory	regulatory	JJ
cord-012418-6ralcn8p	523	45	factor	factor	NN
cord-012418-6ralcn8p	523	46	3	3	CD
cord-012418-6ralcn8p	523	47	and	and	CC
cord-012418-6ralcn8p	523	48	CREB	CREB	NNP
cord-012418-6ralcn8p	523	49	-	-	HYPH
cord-012418-6ralcn8p	523	50	binding	bind	VBG
cord-012418-6ralcn8p	523	51	protein/	protein/	ADD
cord-012418-6ralcn8p	524	1	p300	p300	NNP
cord-012418-6ralcn8p	524	2	are	be	VBP
cord-012418-6ralcn8p	524	3	subunits	subunit	NNS
cord-012418-6ralcn8p	524	4	of	of	IN
cord-012418-6ralcn8p	524	5	double	double	RB
cord-012418-6ralcn8p	524	6	-	-	HYPH
cord-012418-6ralcn8p	524	7	stranded	strand	VBN
cord-012418-6ralcn8p	524	8	RNA	RNA	NNP
cord-012418-6ralcn8p	524	9	-	-	HYPH
cord-012418-6ralcn8p	524	10	activated	activate	VBN
cord-012418-6ralcn8p	524	11	transcription	transcription	NN
cord-012418-6ralcn8p	524	12	factor	factor	NN
cord-012418-6ralcn8p	525	1	DRAF1	draf1	NN
cord-012418-6ralcn8p	525	2	Analyses	analysis	NNS
cord-012418-6ralcn8p	525	3	of	of	IN
cord-012418-6ralcn8p	525	4	virus	virus	NN
cord-012418-6ralcn8p	525	5	-	-	HYPH
cord-012418-6ralcn8p	525	6	induced	induce	VBN
cord-012418-6ralcn8p	525	7	homomeric	homomeric	NNP
cord-012418-6ralcn8p	525	8	and	and	CC
cord-012418-6ralcn8p	525	9	heteromeric	heteromeric	VBD
cord-012418-6ralcn8p	525	10	protein	protein	NN
cord-012418-6ralcn8p	525	11	associations	association	NNS
cord-012418-6ralcn8p	525	12	between	between	IN
cord-012418-6ralcn8p	525	13	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	525	14	and	and	CC
cord-012418-6ralcn8p	525	15	coactivator	coactivator	NNP
cord-012418-6ralcn8p	525	16	CBP	CBP	NNP
cord-012418-6ralcn8p	525	17	/	/	SYM
cord-012418-6ralcn8p	525	18	p300	p300	NNP
cord-012418-6ralcn8p	525	19	Direct	direct	JJ
cord-012418-6ralcn8p	525	20	involvement	involvement	NN
cord-012418-6ralcn8p	525	21	of	of	IN
cord-012418-6ralcn8p	525	22	CREB	CREB	NNP
cord-012418-6ralcn8p	525	23	-	-	HYPH
cord-012418-6ralcn8p	525	24	binding	bind	VBG
cord-012418-6ralcn8p	525	25	protein	protein	NN
cord-012418-6ralcn8p	525	26	/	/	SYM
cord-012418-6ralcn8p	525	27	p300	p300	NN
cord-012418-6ralcn8p	525	28	in	in	IN
cord-012418-6ralcn8p	525	29	sequence	sequence	NN
cord-012418-6ralcn8p	525	30	-	-	HYPH
cord-012418-6ralcn8p	525	31	specific	specific	JJ
cord-012418-6ralcn8p	525	32	DNA	dna	NN
cord-012418-6ralcn8p	525	33	binding	binding	NN
cord-012418-6ralcn8p	525	34	of	of	IN
cord-012418-6ralcn8p	525	35	virus	virus	NN
cord-012418-6ralcn8p	525	36	-	-	HYPH
cord-012418-6ralcn8p	525	37	activated	activate	VBN
cord-012418-6ralcn8p	525	38	interferon	interferon	NN
cord-012418-6ralcn8p	525	39	regulatory	regulatory	JJ
cord-012418-6ralcn8p	525	40	factor-3	factor-3	NNP
cord-012418-6ralcn8p	525	41	holocomplex	holocomplex	NNP
cord-012418-6ralcn8p	525	42	Transcriptional	Transcriptional	NNP
cord-012418-6ralcn8p	525	43	activity	activity	NN
cord-012418-6ralcn8p	525	44	of	of	IN
cord-012418-6ralcn8p	525	45	interferon	interferon	NN
cord-012418-6ralcn8p	525	46	regulatory	regulatory	JJ
cord-012418-6ralcn8p	525	47	factor	factor	NN
cord-012418-6ralcn8p	525	48	(	(	-LRB-
cord-012418-6ralcn8p	525	49	IRF)-3	irf)-3	NN
cord-012418-6ralcn8p	525	50	depends	depend	VBZ
cord-012418-6ralcn8p	525	51	on	on	IN
cord-012418-6ralcn8p	525	52	multiple	multiple	JJ
cord-012418-6ralcn8p	525	53	protein	protein	NN
cord-012418-6ralcn8p	525	54	-	-	HYPH
cord-012418-6ralcn8p	525	55	protein	protein	NN
cord-012418-6ralcn8p	525	56	interactions	interaction	NNS
cord-012418-6ralcn8p	525	57	Role	role	NN
cord-012418-6ralcn8p	525	58	of	of	IN
cord-012418-6ralcn8p	525	59	Intrinsic	Intrinsic	NNP
cord-012418-6ralcn8p	525	60	Protein	Protein	NNP
cord-012418-6ralcn8p	525	61	Disorder	Disorder	NNP
cord-012418-6ralcn8p	525	62	in	in	IN
cord-012418-6ralcn8p	525	63	the	the	DT
cord-012418-6ralcn8p	525	64	Function	Function	NNP
cord-012418-6ralcn8p	525	65	and	and	CC
cord-012418-6ralcn8p	525	66	Interactions	Interactions	NNPS
cord-012418-6ralcn8p	525	67	of	of	IN
cord-012418-6ralcn8p	525	68	the	the	DT
cord-012418-6ralcn8p	525	69	Transcriptional	Transcriptional	NNP
cord-012418-6ralcn8p	525	70	Coactivators	Coactivators	NNP
cord-012418-6ralcn8p	525	71	CREB	CREB	NNP
cord-012418-6ralcn8p	525	72	-	-	HYPH
cord-012418-6ralcn8p	525	73	binding	bind	VBG
cord-012418-6ralcn8p	525	74	Protein	Protein	NNP
cord-012418-6ralcn8p	525	75	(	(	-LRB-
cord-012418-6ralcn8p	525	76	CBP	CBP	NNP
cord-012418-6ralcn8p	525	77	)	)	-RRB-
cord-012418-6ralcn8p	525	78	and	and	CC
cord-012418-6ralcn8p	525	79	p300	p300	NNP
cord-012418-6ralcn8p	525	80	Target	Target	NNP
cord-012418-6ralcn8p	525	81	gene	gene	NN
cord-012418-6ralcn8p	525	82	context	context	NN
cord-012418-6ralcn8p	525	83	influences	influence	VBZ
cord-012418-6ralcn8p	525	84	the	the	DT
cord-012418-6ralcn8p	525	85	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	525	86	requirement	requirement	NN
cord-012418-6ralcn8p	525	87	for	for	IN
cord-012418-6ralcn8p	525	88	the	the	DT
cord-012418-6ralcn8p	525	89	KAT3	KAT3	NNP
cord-012418-6ralcn8p	525	90	family	family	NN
cord-012418-6ralcn8p	525	91	of	of	IN
cord-012418-6ralcn8p	525	92	CBP	CBP	NNP
cord-012418-6ralcn8p	525	93	and	and	CC
cord-012418-6ralcn8p	525	94	p300	p300	NNP
cord-012418-6ralcn8p	525	95	histone	histone	NN
cord-012418-6ralcn8p	526	1	acetyltransferases	acetyltransferases	NNP
cord-012418-6ralcn8p	526	2	Genome	Genome	NNP
cord-012418-6ralcn8p	526	3	-	-	HYPH
cord-012418-6ralcn8p	526	4	wide	wide	JJ
cord-012418-6ralcn8p	526	5	assessment	assessment	NN
cord-012418-6ralcn8p	526	6	of	of	IN
cord-012418-6ralcn8p	526	7	differential	differential	JJ
cord-012418-6ralcn8p	526	8	roles	role	NNS
cord-012418-6ralcn8p	526	9	for	for	IN
cord-012418-6ralcn8p	526	10	p300	p300	NNP
cord-012418-6ralcn8p	526	11	and	and	CC
cord-012418-6ralcn8p	526	12	CBP	CBP	NNP
cord-012418-6ralcn8p	526	13	in	in	IN
cord-012418-6ralcn8p	526	14	transcription	transcription	NN
cord-012418-6ralcn8p	526	15	regulation	regulation	NN
cord-012418-6ralcn8p	527	1	CBP	CBP	NNP
cord-012418-6ralcn8p	527	2	/	/	SYM
cord-012418-6ralcn8p	527	3	p300	p300	NNP
cord-012418-6ralcn8p	527	4	in	in	IN
cord-012418-6ralcn8p	527	5	brain	brain	NN
cord-012418-6ralcn8p	527	6	development	development	NN
cord-012418-6ralcn8p	527	7	and	and	CC
cord-012418-6ralcn8p	527	8	plasticity	plasticity	NN
cord-012418-6ralcn8p	527	9	:	:	:
cord-012418-6ralcn8p	528	1	Disentangling	disentangle	VBG
cord-012418-6ralcn8p	528	2	the	the	DT
cord-012418-6ralcn8p	528	3	KAT	KAT	NNP
cord-012418-6ralcn8p	528	4	's	's	POS
cord-012418-6ralcn8p	528	5	cradle	cradle	NN
cord-012418-6ralcn8p	528	6	USP22	USP22	NNP
cord-012418-6ralcn8p	528	7	promotes	promote	VBZ
cord-012418-6ralcn8p	528	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	528	9	nuclear	nuclear	JJ
cord-012418-6ralcn8p	528	10	translocation	translocation	NN
cord-012418-6ralcn8p	528	11	and	and	CC
cord-012418-6ralcn8p	528	12	antiviral	antiviral	JJ
cord-012418-6ralcn8p	528	13	responses	response	NNS
cord-012418-6ralcn8p	528	14	by	by	IN
cord-012418-6ralcn8p	528	15	deubiquitinating	deubiquitinate	VBG
cord-012418-6ralcn8p	528	16	the	the	DT
cord-012418-6ralcn8p	528	17	importin	importin	NNP
cord-012418-6ralcn8p	528	18	protein	protein	NN
cord-012418-6ralcn8p	528	19	KPNA2	KPNA2	NNP
cord-012418-6ralcn8p	528	20	Transcription	Transcription	NNP
cord-012418-6ralcn8p	528	21	factor	factor	NN
cord-012418-6ralcn8p	528	22	dimerization	dimerization	NN
cord-012418-6ralcn8p	528	23	activates	activate	VBZ
cord-012418-6ralcn8p	528	24	the	the	DT
cord-012418-6ralcn8p	528	25	p300	p300	NNP
cord-012418-6ralcn8p	528	26	acetyltransferase	acetyltransferase	NNP
cord-012418-6ralcn8p	528	27	Differential	Differential	NNP
cord-012418-6ralcn8p	528	28	modification	modification	NN
cord-012418-6ralcn8p	528	29	of	of	IN
cord-012418-6ralcn8p	528	30	interferon	interferon	NN
cord-012418-6ralcn8p	528	31	regulatory	regulatory	JJ
cord-012418-6ralcn8p	528	32	factor	factor	NN
cord-012418-6ralcn8p	528	33	3	3	CD
cord-012418-6ralcn8p	528	34	following	follow	VBG
cord-012418-6ralcn8p	528	35	virus	virus	NN
cord-012418-6ralcn8p	528	36	particle	particle	NN
cord-012418-6ralcn8p	528	37	entry	entry	NN
cord-012418-6ralcn8p	528	38	Inhibition	inhibition	NN
cord-012418-6ralcn8p	528	39	of	of	IN
cord-012418-6ralcn8p	528	40	Beta	Beta	NNP
cord-012418-6ralcn8p	528	41	interferon	interferon	NN
cord-012418-6ralcn8p	528	42	induction	induction	NN
cord-012418-6ralcn8p	528	43	by	by	IN
cord-012418-6ralcn8p	528	44	severe	severe	JJ
cord-012418-6ralcn8p	528	45	acute	acute	JJ
cord-012418-6ralcn8p	528	46	respiratory	respiratory	JJ
cord-012418-6ralcn8p	528	47	syndrome	syndrome	NN
cord-012418-6ralcn8p	528	48	coronavirus	coronavirus	NN
cord-012418-6ralcn8p	529	1	suggests	suggest	VBZ
cord-012418-6ralcn8p	529	2	a	a	DT
cord-012418-6ralcn8p	529	3	two	two	CD
cord-012418-6ralcn8p	529	4	-	-	HYPH
cord-012418-6ralcn8p	529	5	step	step	NN
cord-012418-6ralcn8p	529	6	model	model	NN
cord-012418-6ralcn8p	529	7	for	for	IN
cord-012418-6ralcn8p	529	8	activation	activation	NN
cord-012418-6ralcn8p	529	9	of	of	IN
cord-012418-6ralcn8p	529	10	interferon	interferon	NN
cord-012418-6ralcn8p	529	11	regulatory	regulatory	JJ
cord-012418-6ralcn8p	529	12	factor	factor	NN
cord-012418-6ralcn8p	529	13	3	3	CD
cord-012418-6ralcn8p	529	14	Transcriptional	Transcriptional	NNP
cord-012418-6ralcn8p	529	15	profiling	profiling	NN
cord-012418-6ralcn8p	529	16	of	of	IN
cord-012418-6ralcn8p	529	17	interferon	interferon	NN
cord-012418-6ralcn8p	529	18	regulatory	regulatory	JJ
cord-012418-6ralcn8p	529	19	factor	factor	NN
cord-012418-6ralcn8p	529	20	3	3	CD
cord-012418-6ralcn8p	529	21	target	target	NN
cord-012418-6ralcn8p	529	22	genes	gene	NNS
cord-012418-6ralcn8p	529	23	:	:	:
cord-012418-6ralcn8p	529	24	Direct	direct	JJ
cord-012418-6ralcn8p	529	25	involvement	involvement	NN
cord-012418-6ralcn8p	529	26	in	in	IN
cord-012418-6ralcn8p	529	27	the	the	DT
cord-012418-6ralcn8p	529	28	regulation	regulation	NN
cord-012418-6ralcn8p	529	29	of	of	IN
cord-012418-6ralcn8p	529	30	interferon	interferon	NN
cord-012418-6ralcn8p	529	31	-	-	HYPH
cord-012418-6ralcn8p	529	32	stimulated	stimulate	VBN
cord-012418-6ralcn8p	529	33	genes	gene	NNS
cord-012418-6ralcn8p	529	34	Complex	Complex	NNP
cord-012418-6ralcn8p	529	35	Regulation	Regulation	NNP
cord-012418-6ralcn8p	529	36	Pattern	Pattern	NNP
cord-012418-6ralcn8p	529	37	of	of	IN
cord-012418-6ralcn8p	529	38	IRF3	IRF3	NNP
cord-012418-6ralcn8p	529	39	Activation	Activation	NNP
cord-012418-6ralcn8p	529	40	Revealed	reveal	VBN
cord-012418-6ralcn8p	529	41	by	by	IN
cord-012418-6ralcn8p	529	42	a	a	DT
cord-012418-6ralcn8p	529	43	Novel	Novel	NNP
cord-012418-6ralcn8p	529	44	Dimerization	Dimerization	NNP
cord-012418-6ralcn8p	529	45	Reporter	reporter	NN
cord-012418-6ralcn8p	529	46	System	System	NNP
cord-012418-6ralcn8p	529	47	Structure	Structure	NNP
cord-012418-6ralcn8p	529	48	and	and	CC
cord-012418-6ralcn8p	529	49	function	function	NN
cord-012418-6ralcn8p	529	50	of	of	IN
cord-012418-6ralcn8p	529	51	the	the	DT
cord-012418-6ralcn8p	529	52	interferon	interferon	NN
cord-012418-6ralcn8p	529	53	-	-	HYPH
cord-012418-6ralcn8p	529	54	beta	beta	NN
cord-012418-6ralcn8p	529	55	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	530	1	The	the	DT
cord-012418-6ralcn8p	530	2	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	530	3	Virus	virus	NN
cord-012418-6ralcn8p	530	4	induction	induction	NN
cord-012418-6ralcn8p	530	5	of	of	IN
cord-012418-6ralcn8p	530	6	human	human	JJ
cord-012418-6ralcn8p	530	7	IFN	IFN	NNP
cord-012418-6ralcn8p	530	8	beta	beta	NN
cord-012418-6ralcn8p	530	9	gene	gene	NN
cord-012418-6ralcn8p	530	10	expression	expression	NN
cord-012418-6ralcn8p	530	11	requires	require	VBZ
cord-012418-6ralcn8p	530	12	the	the	DT
cord-012418-6ralcn8p	530	13	assembly	assembly	NN
cord-012418-6ralcn8p	530	14	of	of	IN
cord-012418-6ralcn8p	530	15	an	an	DT
cord-012418-6ralcn8p	530	16	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	530	17	Coordination	Coordination	NNP
cord-012418-6ralcn8p	530	18	of	of	IN
cord-012418-6ralcn8p	530	19	a	a	DT
cord-012418-6ralcn8p	530	20	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	530	21	switch	switch	NN
cord-012418-6ralcn8p	530	22	by	by	IN
cord-012418-6ralcn8p	530	23	HMGI(Y	hmgi(y	CD
cord-012418-6ralcn8p	530	24	)	)	-RRB-
cord-012418-6ralcn8p	531	1	acetylation	acetylation	NN
cord-012418-6ralcn8p	531	2	Ordered	order	VBD
cord-012418-6ralcn8p	531	3	recruitment	recruitment	NN
cord-012418-6ralcn8p	531	4	of	of	IN
cord-012418-6ralcn8p	531	5	chromatin	chromatin	NN
cord-012418-6ralcn8p	531	6	modifying	modify	VBG
cord-012418-6ralcn8p	531	7	and	and	CC
cord-012418-6ralcn8p	531	8	general	general	JJ
cord-012418-6ralcn8p	531	9	transcription	transcription	NN
cord-012418-6ralcn8p	531	10	factors	factor	NNS
cord-012418-6ralcn8p	531	11	to	to	IN
cord-012418-6ralcn8p	531	12	the	the	DT
cord-012418-6ralcn8p	531	13	IFN	IFN	NNP
cord-012418-6ralcn8p	531	14	-	-	HYPH
cord-012418-6ralcn8p	531	15	beta	beta	NN
cord-012418-6ralcn8p	531	16	promoter	promoter	NN
cord-012418-6ralcn8p	531	17	Facilitated	facilitate	VBN
cord-012418-6ralcn8p	531	18	binding	binding	NN
cord-012418-6ralcn8p	531	19	of	of	IN
cord-012418-6ralcn8p	531	20	TATA	TATA	NNP
cord-012418-6ralcn8p	531	21	-	-	HYPH
cord-012418-6ralcn8p	531	22	binding	bind	VBG
cord-012418-6ralcn8p	531	23	protein	protein	NN
cord-012418-6ralcn8p	531	24	to	to	IN
cord-012418-6ralcn8p	531	25	nucleosomal	nucleosomal	NNP
cord-012418-6ralcn8p	531	26	DNA	DNA	NNP
cord-012418-6ralcn8p	531	27	Modifying	modify	VBG
cord-012418-6ralcn8p	531	28	gene	gene	NN
cord-012418-6ralcn8p	531	29	expression	expression	NN
cord-012418-6ralcn8p	531	30	programs	program	NNS
cord-012418-6ralcn8p	531	31	by	by	IN
cord-012418-6ralcn8p	531	32	altering	alter	VBG
cord-012418-6ralcn8p	531	33	core	core	NN
cord-012418-6ralcn8p	531	34	promoter	promoter	NN
cord-012418-6ralcn8p	531	35	chromatin	chromatin	NN
cord-012418-6ralcn8p	531	36	architecture	architecture	NN
cord-012418-6ralcn8p	531	37	DNA	dna	NN
cord-012418-6ralcn8p	531	38	-	-	HYPH
cord-012418-6ralcn8p	531	39	binding	bind	VBG
cord-012418-6ralcn8p	531	40	landscape	landscape	NN
cord-012418-6ralcn8p	531	41	of	of	IN
cord-012418-6ralcn8p	531	42	IRF3	IRF3	NNP
cord-012418-6ralcn8p	531	43	,	,	,
cord-012418-6ralcn8p	531	44	IRF5	IRF5	NNP
cord-012418-6ralcn8p	531	45	and	and	CC
cord-012418-6ralcn8p	531	46	IRF7	IRF7	NNP
cord-012418-6ralcn8p	531	47	dimers	dimer	NNS
cord-012418-6ralcn8p	531	48	:	:	:
cord-012418-6ralcn8p	531	49	Implications	implication	NNS
cord-012418-6ralcn8p	531	50	for	for	IN
cord-012418-6ralcn8p	531	51	dimer	dimer	NN
cord-012418-6ralcn8p	531	52	-	-	HYPH
cord-012418-6ralcn8p	531	53	specific	specific	JJ
cord-012418-6ralcn8p	531	54	gene	gene	NN
cord-012418-6ralcn8p	531	55	regulation	regulation	NN
cord-012418-6ralcn8p	532	1	An	an	DT
cord-012418-6ralcn8p	532	2	ATF	ATF	NNP
cord-012418-6ralcn8p	532	3	/	/	SYM
cord-012418-6ralcn8p	532	4	CREB	CREB	NNP
cord-012418-6ralcn8p	532	5	binding	binding	NN
cord-012418-6ralcn8p	532	6	site	site	NN
cord-012418-6ralcn8p	532	7	is	be	VBZ
cord-012418-6ralcn8p	532	8	required	require	VBN
cord-012418-6ralcn8p	532	9	for	for	IN
cord-012418-6ralcn8p	532	10	virus	virus	NN
cord-012418-6ralcn8p	532	11	induction	induction	NN
cord-012418-6ralcn8p	532	12	of	of	IN
cord-012418-6ralcn8p	532	13	the	the	DT
cord-012418-6ralcn8p	532	14	human	human	JJ
cord-012418-6ralcn8p	532	15	interferon	interferon	NN
cord-012418-6ralcn8p	532	16	beta	beta	NN
cord-012418-6ralcn8p	532	17	gene	gene	NN
cord-012418-6ralcn8p	532	18	Proc	proc	NN
cord-012418-6ralcn8p	532	19	.	.	.
cord-012418-6ralcn8p	533	1	Natl	Natl	NNP
cord-012418-6ralcn8p	533	2	.	.	.
cord-012418-6ralcn8p	534	1	Acad	Acad	NNP
cord-012418-6ralcn8p	534	2	.	.	.
cord-012418-6ralcn8p	535	1	Sci	Sci	NNP
cord-012418-6ralcn8p	535	2	.	.	.
cord-012418-6ralcn8p	536	1	USA	USA	NNP
cord-012418-6ralcn8p	536	2	Stability	Stability	NNP
cord-012418-6ralcn8p	536	3	and	and	CC
cord-012418-6ralcn8p	536	4	DNA	dna	NN
cord-012418-6ralcn8p	536	5	-	-	HYPH
cord-012418-6ralcn8p	536	6	binding	bind	VBG
cord-012418-6ralcn8p	536	7	ability	ability	NN
cord-012418-6ralcn8p	536	8	of	of	IN
cord-012418-6ralcn8p	536	9	the	the	DT
cord-012418-6ralcn8p	536	10	bZIP	bZIP	VBG
cord-012418-6ralcn8p	536	11	dimers	dimer	NNS
cord-012418-6ralcn8p	536	12	formed	form	VBN
cord-012418-6ralcn8p	536	13	by	by	IN
cord-012418-6ralcn8p	536	14	the	the	DT
cord-012418-6ralcn8p	536	15	ATF-2	ATF-2	NNP
cord-012418-6ralcn8p	536	16	and	and	CC
cord-012418-6ralcn8p	537	1	c	c	LS
cord-012418-6ralcn8p	537	2	-	-	:
cord-012418-6ralcn8p	537	3	Jun	Jun	NNP
cord-012418-6ralcn8p	537	4	transcription	transcription	NN
cord-012418-6ralcn8p	537	5	factors	factor	NNS
cord-012418-6ralcn8p	537	6	Induction	Induction	NNP
cord-012418-6ralcn8p	537	7	of	of	IN
cord-012418-6ralcn8p	537	8	human	human	JJ
cord-012418-6ralcn8p	537	9	interferon	interferon	NN
cord-012418-6ralcn8p	537	10	gene	gene	NN
cord-012418-6ralcn8p	537	11	expression	expression	NN
cord-012418-6ralcn8p	537	12	is	be	VBZ
cord-012418-6ralcn8p	537	13	associated	associate	VBN
cord-012418-6ralcn8p	537	14	with	with	IN
cord-012418-6ralcn8p	537	15	a	a	DT
cord-012418-6ralcn8p	537	16	nuclear	nuclear	JJ
cord-012418-6ralcn8p	537	17	factor	factor	NN
cord-012418-6ralcn8p	537	18	that	that	WDT
cord-012418-6ralcn8p	537	19	interacts	interact	VBZ
cord-012418-6ralcn8p	537	20	with	with	IN
cord-012418-6ralcn8p	537	21	the	the	DT
cord-012418-6ralcn8p	537	22	NF	nf	NN
cord-012418-6ralcn8p	537	23	-	-	HYPH
cord-012418-6ralcn8p	537	24	kappa	kappa	NN
cord-012418-6ralcn8p	537	25	B	B	NNP
cord-012418-6ralcn8p	537	26	site	site	NN
cord-012418-6ralcn8p	537	27	of	of	IN
cord-012418-6ralcn8p	537	28	the	the	DT
cord-012418-6ralcn8p	537	29	human	human	JJ
cord-012418-6ralcn8p	537	30	immunodeficiency	immunodeficiency	NN
cord-012418-6ralcn8p	537	31	virus	virus	NN
cord-012418-6ralcn8p	537	32	enhancer	enhancer	NN
cord-012418-6ralcn8p	538	1	The	the	DT
cord-012418-6ralcn8p	538	2	involvement	involvement	NN
cord-012418-6ralcn8p	538	3	of	of	IN
cord-012418-6ralcn8p	538	4	NF	nf	NN
cord-012418-6ralcn8p	538	5	-	-	HYPH
cord-012418-6ralcn8p	538	6	kappa	kappa	NN
cord-012418-6ralcn8p	538	7	B	b	NN
cord-012418-6ralcn8p	538	8	in	in	IN
cord-012418-6ralcn8p	538	9	beta	beta	NN
cord-012418-6ralcn8p	538	10	-	-	HYPH
cord-012418-6ralcn8p	538	11	interferon	interferon	NN
cord-012418-6ralcn8p	538	12	gene	gene	NN
cord-012418-6ralcn8p	538	13	regulation	regulation	NN
cord-012418-6ralcn8p	538	14	reveals	reveal	VBZ
cord-012418-6ralcn8p	538	15	its	-PRON-	PRP$
cord-012418-6ralcn8p	538	16	role	role	NN
cord-012418-6ralcn8p	538	17	as	as	RB
cord-012418-6ralcn8p	538	18	widely	widely	RB
cord-012418-6ralcn8p	538	19	inducible	inducible	JJ
cord-012418-6ralcn8p	538	20	mediator	mediator	NN
cord-012418-6ralcn8p	538	21	of	of	IN
cord-012418-6ralcn8p	538	22	signal	signal	NN
cord-012418-6ralcn8p	538	23	transduction	transduction	NN
cord-012418-6ralcn8p	538	24	Double	double	RB
cord-012418-6ralcn8p	538	25	-	-	HYPH
cord-012418-6ralcn8p	538	26	stranded	strand	VBN
cord-012418-6ralcn8p	538	27	RNA	RNA	NNP
cord-012418-6ralcn8p	538	28	activates	activate	VBZ
cord-012418-6ralcn8p	538	29	binding	binding	NN
cord-012418-6ralcn8p	538	30	of	of	IN
cord-012418-6ralcn8p	538	31	NF	nf	NN
cord-012418-6ralcn8p	538	32	-	-	HYPH
cord-012418-6ralcn8p	538	33	kappa	kappa	NN
cord-012418-6ralcn8p	538	34	B	B	NNP
cord-012418-6ralcn8p	538	35	to	to	IN
cord-012418-6ralcn8p	538	36	an	an	DT
cord-012418-6ralcn8p	538	37	inducible	inducible	JJ
cord-012418-6ralcn8p	538	38	element	element	NN
cord-012418-6ralcn8p	538	39	in	in	IN
cord-012418-6ralcn8p	538	40	the	the	DT
cord-012418-6ralcn8p	538	41	human	human	JJ
cord-012418-6ralcn8p	538	42	beta	beta	NN
cord-012418-6ralcn8p	538	43	-	-	HYPH
cord-012418-6ralcn8p	538	44	interferon	interferon	NN
cord-012418-6ralcn8p	538	45	promoter	promoter	NN
cord-012418-6ralcn8p	538	46	Crystal	Crystal	NNP
cord-012418-6ralcn8p	538	47	structure	structure	NN
cord-012418-6ralcn8p	538	48	of	of	IN
cord-012418-6ralcn8p	538	49	an	an	DT
cord-012418-6ralcn8p	538	50	IRF	IRF	NNP
cord-012418-6ralcn8p	538	51	-	-	HYPH
cord-012418-6ralcn8p	538	52	DNA	dna	NN
cord-012418-6ralcn8p	538	53	complex	complex	NN
cord-012418-6ralcn8p	539	1	reveals	reveal	VBZ
cord-012418-6ralcn8p	539	2	novel	novel	JJ
cord-012418-6ralcn8p	539	3	DNA	dna	NN
cord-012418-6ralcn8p	539	4	recognition	recognition	NN
cord-012418-6ralcn8p	539	5	and	and	CC
cord-012418-6ralcn8p	539	6	cooperative	cooperative	JJ
cord-012418-6ralcn8p	539	7	binding	binding	NN
cord-012418-6ralcn8p	539	8	to	to	IN
cord-012418-6ralcn8p	539	9	a	a	DT
cord-012418-6ralcn8p	539	10	tandem	tandem	JJ
cord-012418-6ralcn8p	539	11	repeat	repeat	NN
cord-012418-6ralcn8p	539	12	of	of	IN
cord-012418-6ralcn8p	539	13	core	core	NN
cord-012418-6ralcn8p	539	14	sequences	sequence	NNS
cord-012418-6ralcn8p	540	1	An	an	DT
cord-012418-6ralcn8p	540	2	atomic	atomic	JJ
cord-012418-6ralcn8p	540	3	model	model	NN
cord-012418-6ralcn8p	540	4	of	of	IN
cord-012418-6ralcn8p	540	5	the	the	DT
cord-012418-6ralcn8p	540	6	interferon	interferon	NN
cord-012418-6ralcn8p	540	7	-	-	HYPH
cord-012418-6ralcn8p	540	8	beta	beta	NN
cord-012418-6ralcn8p	540	9	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	540	10	Specific	specific	JJ
cord-012418-6ralcn8p	540	11	enhancer	enhancer	NN
cord-012418-6ralcn8p	540	12	selection	selection	NN
cord-012418-6ralcn8p	540	13	by	by	IN
cord-012418-6ralcn8p	540	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	540	15	,	,	,
cord-012418-6ralcn8p	540	16	IRF5	IRF5	NNP
cord-012418-6ralcn8p	540	17	and	and	CC
cord-012418-6ralcn8p	540	18	IRF9	IRF9	NNP
cord-012418-6ralcn8p	540	19	is	be	VBZ
cord-012418-6ralcn8p	540	20	determined	determine	VBN
cord-012418-6ralcn8p	540	21	by	by	IN
cord-012418-6ralcn8p	540	22	ISRE	ISRE	NNP
cord-012418-6ralcn8p	540	23	half	half	JJ
cord-012418-6ralcn8p	540	24	-	-	HYPH
cord-012418-6ralcn8p	540	25	sites	site	NNS
cord-012418-6ralcn8p	540	26	,	,	,
cord-012418-6ralcn8p	540	27	5	5	CD
cord-012418-6ralcn8p	540	28	and	and	CC
cord-012418-6ralcn8p	540	29	3	3	CD
cord-012418-6ralcn8p	540	30	flanking	flanking	JJ
cord-012418-6ralcn8p	540	31	bases	basis	NNS
cord-012418-6ralcn8p	540	32	,	,	,
cord-012418-6ralcn8p	540	33	collaborating	collaborate	VBG
cord-012418-6ralcn8p	540	34	transcription	transcription	NN
cord-012418-6ralcn8p	540	35	factors	factor	NNS
cord-012418-6ralcn8p	540	36	and	and	CC
cord-012418-6ralcn8p	540	37	the	the	DT
cord-012418-6ralcn8p	540	38	chromatin	chromatin	NN
cord-012418-6ralcn8p	540	39	environment	environment	NN
cord-012418-6ralcn8p	540	40	in	in	IN
cord-012418-6ralcn8p	540	41	a	a	DT
cord-012418-6ralcn8p	540	42	combinatorial	combinatorial	JJ
cord-012418-6ralcn8p	540	43	fashion	fashion	NN
cord-012418-6ralcn8p	540	44	Virus	virus	NN
cord-012418-6ralcn8p	540	45	Infection	infection	NN
cord-012418-6ralcn8p	540	46	Induces	induce	VBZ
cord-012418-6ralcn8p	540	47	NF	NF	NNP
cord-012418-6ralcn8p	540	48	-	-	HYPH
cord-012418-6ralcn8p	540	49	kappaB	kappaB	NNP
cord-012418-6ralcn8p	540	50	-	-	HYPH
cord-012418-6ralcn8p	540	51	dependent	dependent	JJ
cord-012418-6ralcn8p	540	52	interchromosomal	interchromosomal	JJ
cord-012418-6ralcn8p	540	53	associations	association	NNS
cord-012418-6ralcn8p	540	54	mediating	mediate	VBG
cord-012418-6ralcn8p	540	55	monoallelic	monoallelic	NNP
cord-012418-6ralcn8p	540	56	IFN	IFN	NNP
cord-012418-6ralcn8p	540	57	-	-	HYPH
cord-012418-6ralcn8p	540	58	beta	beta	NN
cord-012418-6ralcn8p	540	59	gene	gene	NN
cord-012418-6ralcn8p	540	60	expression	expression	NN
cord-012418-6ralcn8p	541	1	The	the	DT
cord-012418-6ralcn8p	541	2	Transcription	Transcription	NNP
cord-012418-6ralcn8p	541	3	Factor	Factor	NNP
cord-012418-6ralcn8p	541	4	ThPOK	ThPOK	NNP
cord-012418-6ralcn8p	541	5	Orchestrates	orchestrate	VBZ
cord-012418-6ralcn8p	541	6	Stochastic	stochastic	JJ
cord-012418-6ralcn8p	541	7	Interchromosomal	Interchromosomal	NNP
cord-012418-6ralcn8p	541	8	Interactions	Interactions	NNPS
cord-012418-6ralcn8p	541	9	Required	require	VBN
cord-012418-6ralcn8p	541	10	for	for	IN
cord-012418-6ralcn8p	541	11	IFNB1	IFNB1	NNP
cord-012418-6ralcn8p	542	1	Virus	virus	NN
cord-012418-6ralcn8p	542	2	-	-	HYPH
cord-012418-6ralcn8p	542	3	Inducible	Inducible	NNP
cord-012418-6ralcn8p	542	4	Gene	Gene	NNP
cord-012418-6ralcn8p	542	5	Expression	expression	NN
cord-012418-6ralcn8p	543	1	The	the	DT
cord-012418-6ralcn8p	543	2	high	high	JJ
cord-012418-6ralcn8p	543	3	mobility	mobility	NN
cord-012418-6ralcn8p	543	4	group	group	NN
cord-012418-6ralcn8p	543	5	protein	protein	NN
cord-012418-6ralcn8p	543	6	HMG	HMG	NNP
cord-012418-6ralcn8p	543	7	I(Y	I(Y	NNP
cord-012418-6ralcn8p	543	8	)	)	-RRB-
cord-012418-6ralcn8p	543	9	is	be	VBZ
cord-012418-6ralcn8p	543	10	required	require	VBN
cord-012418-6ralcn8p	543	11	for	for	IN
cord-012418-6ralcn8p	543	12	NF	nf	NN
cord-012418-6ralcn8p	543	13	-	-	HYPH
cord-012418-6ralcn8p	543	14	kappa	kappa	NN
cord-012418-6ralcn8p	543	15	B	b	NN
cord-012418-6ralcn8p	543	16	-	-	HYPH
cord-012418-6ralcn8p	543	17	dependent	dependent	JJ
cord-012418-6ralcn8p	543	18	virus	virus	NN
cord-012418-6ralcn8p	543	19	induction	induction	NN
cord-012418-6ralcn8p	543	20	of	of	IN
cord-012418-6ralcn8p	543	21	the	the	DT
cord-012418-6ralcn8p	543	22	human	human	JJ
cord-012418-6ralcn8p	543	23	IFN	IFN	NNP
cord-012418-6ralcn8p	543	24	-	-	HYPH
cord-012418-6ralcn8p	543	25	beta	beta	NN
cord-012418-6ralcn8p	543	26	gene	gene	NN
cord-012418-6ralcn8p	543	27	Reversal	reversal	NN
cord-012418-6ralcn8p	543	28	of	of	IN
cord-012418-6ralcn8p	543	29	intrinsic	intrinsic	JJ
cord-012418-6ralcn8p	543	30	DNA	dna	NN
cord-012418-6ralcn8p	543	31	bends	bend	NNS
cord-012418-6ralcn8p	543	32	in	in	IN
cord-012418-6ralcn8p	543	33	the	the	DT
cord-012418-6ralcn8p	543	34	IFN	IFN	NNP
cord-012418-6ralcn8p	543	35	beta	beta	NN
cord-012418-6ralcn8p	543	36	gene	gene	NN
cord-012418-6ralcn8p	543	37	enhancer	enhancer	NN
cord-012418-6ralcn8p	543	38	by	by	IN
cord-012418-6ralcn8p	543	39	transcription	transcription	NN
cord-012418-6ralcn8p	543	40	factors	factor	NNS
cord-012418-6ralcn8p	543	41	and	and	CC
cord-012418-6ralcn8p	543	42	the	the	DT
cord-012418-6ralcn8p	543	43	architectural	architectural	JJ
cord-012418-6ralcn8p	543	44	protein	protein	NN
cord-012418-6ralcn8p	543	45	HMG	HMG	NNP
cord-012418-6ralcn8p	543	46	I(Y	I(Y	NNP
cord-012418-6ralcn8p	543	47	)	)	-RRB-
cord-012418-6ralcn8p	544	1	The	the	DT
cord-012418-6ralcn8p	544	2	mechanism	mechanism	NN
cord-012418-6ralcn8p	544	3	of	of	IN
cord-012418-6ralcn8p	544	4	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	544	5	synergy	synergy	NN
cord-012418-6ralcn8p	544	6	of	of	IN
cord-012418-6ralcn8p	544	7	an	an	DT
cord-012418-6ralcn8p	544	8	in	in	FW
cord-012418-6ralcn8p	544	9	vitro	vitro	FW
cord-012418-6ralcn8p	544	10	assembled	assemble	VBN
cord-012418-6ralcn8p	544	11	interferon	interferon	NN
cord-012418-6ralcn8p	544	12	-	-	HYPH
cord-012418-6ralcn8p	544	13	beta	beta	NN
cord-012418-6ralcn8p	544	14	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	545	1	The	the	DT
cord-012418-6ralcn8p	545	2	role	role	NN
cord-012418-6ralcn8p	545	3	of	of	IN
cord-012418-6ralcn8p	545	4	HMG	HMG	NNP
cord-012418-6ralcn8p	545	5	I(Y	I(Y	NNP
cord-012418-6ralcn8p	545	6	)	)	-RRB-
cord-012418-6ralcn8p	545	7	in	in	IN
cord-012418-6ralcn8p	545	8	the	the	DT
cord-012418-6ralcn8p	545	9	assembly	assembly	NN
cord-012418-6ralcn8p	545	10	and	and	CC
cord-012418-6ralcn8p	545	11	function	function	NN
cord-012418-6ralcn8p	545	12	of	of	IN
cord-012418-6ralcn8p	545	13	the	the	DT
cord-012418-6ralcn8p	545	14	IFN	IFN	NNP
cord-012418-6ralcn8p	545	15	-	-	HYPH
cord-012418-6ralcn8p	545	16	beta	beta	NN
cord-012418-6ralcn8p	545	17	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	545	18	Mechanisms	Mechanisms	NNPS
cord-012418-6ralcn8p	545	19	of	of	IN
cord-012418-6ralcn8p	545	20	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	545	21	synergism	synergism	NN
cord-012418-6ralcn8p	545	22	between	between	IN
cord-012418-6ralcn8p	545	23	distinct	distinct	JJ
cord-012418-6ralcn8p	545	24	virus	virus	NN
cord-012418-6ralcn8p	545	25	-	-	HYPH
cord-012418-6ralcn8p	545	26	inducible	inducible	JJ
cord-012418-6ralcn8p	545	27	enhancer	enhancer	NN
cord-012418-6ralcn8p	545	28	elements	element	NNS
cord-012418-6ralcn8p	545	29	Recruitment	Recruitment	NNP
cord-012418-6ralcn8p	545	30	of	of	IN
cord-012418-6ralcn8p	545	31	CBP	CBP	NNP
cord-012418-6ralcn8p	545	32	/	/	SYM
cord-012418-6ralcn8p	545	33	p300	p300	NNP
cord-012418-6ralcn8p	545	34	by	by	IN
cord-012418-6ralcn8p	545	35	the	the	DT
cord-012418-6ralcn8p	545	36	IFN	IFN	NNP
cord-012418-6ralcn8p	545	37	beta	beta	NN
cord-012418-6ralcn8p	545	38	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	545	39	is	be	VBZ
cord-012418-6ralcn8p	545	40	required	require	VBN
cord-012418-6ralcn8p	545	41	for	for	IN
cord-012418-6ralcn8p	545	42	synergistic	synergistic	JJ
cord-012418-6ralcn8p	545	43	activation	activation	NN
cord-012418-6ralcn8p	545	44	of	of	IN
cord-012418-6ralcn8p	545	45	transcription	transcription	NN
cord-012418-6ralcn8p	545	46	Induction	Induction	NNP
cord-012418-6ralcn8p	545	47	of	of	IN
cord-012418-6ralcn8p	545	48	endogenous	endogenous	JJ
cord-012418-6ralcn8p	545	49	IFN	IFN	NNP
cord-012418-6ralcn8p	545	50	-	-	HYPH
cord-012418-6ralcn8p	545	51	alpha	alpha	NN
cord-012418-6ralcn8p	545	52	and	and	CC
cord-012418-6ralcn8p	545	53	IFN	IFN	NNP
cord-012418-6ralcn8p	545	54	-	-	HYPH
cord-012418-6ralcn8p	545	55	beta	beta	NN
cord-012418-6ralcn8p	545	56	genes	gene	NNS
cord-012418-6ralcn8p	545	57	by	by	IN
cord-012418-6ralcn8p	545	58	a	a	DT
cord-012418-6ralcn8p	545	59	regulatory	regulatory	JJ
cord-012418-6ralcn8p	545	60	transcription	transcription	NN
cord-012418-6ralcn8p	545	61	factor	factor	NN
cord-012418-6ralcn8p	545	62	,	,	,
cord-012418-6ralcn8p	545	63	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	545	64	Evidence	evidence	NN
cord-012418-6ralcn8p	545	65	for	for	IN
cord-012418-6ralcn8p	545	66	a	a	DT
cord-012418-6ralcn8p	545	67	nuclear	nuclear	JJ
cord-012418-6ralcn8p	545	68	factor(s	factor(s	NNP
cord-012418-6ralcn8p	545	69	)	)	-RRB-
cord-012418-6ralcn8p	545	70	,	,	,
cord-012418-6ralcn8p	545	71	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	545	72	,	,	,
cord-012418-6ralcn8p	545	73	mediating	mediate	VBG
cord-012418-6ralcn8p	545	74	induction	induction	NN
cord-012418-6ralcn8p	545	75	and	and	CC
cord-012418-6ralcn8p	545	76	silencing	silence	VBG
cord-012418-6ralcn8p	545	77	properties	property	NNS
cord-012418-6ralcn8p	545	78	to	to	IN
cord-012418-6ralcn8p	545	79	human	human	JJ
cord-012418-6ralcn8p	545	80	IFN	IFN	NNP
cord-012418-6ralcn8p	545	81	-	-	HYPH
cord-012418-6ralcn8p	545	82	beta	beta	NN
cord-012418-6ralcn8p	545	83	gene	gene	NN
cord-012418-6ralcn8p	545	84	regulatory	regulatory	JJ
cord-012418-6ralcn8p	545	85	elements	element	NNS
cord-012418-6ralcn8p	545	86	Critical	critical	JJ
cord-012418-6ralcn8p	545	87	role	role	NN
cord-012418-6ralcn8p	545	88	of	of	IN
cord-012418-6ralcn8p	545	89	a	a	DT
cord-012418-6ralcn8p	545	90	common	common	JJ
cord-012418-6ralcn8p	545	91	transcription	transcription	NN
cord-012418-6ralcn8p	545	92	factor	factor	NN
cord-012418-6ralcn8p	545	93	,	,	,
cord-012418-6ralcn8p	545	94	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	545	95	,	,	,
cord-012418-6ralcn8p	545	96	in	in	IN
cord-012418-6ralcn8p	545	97	the	the	DT
cord-012418-6ralcn8p	545	98	regulation	regulation	NN
cord-012418-6ralcn8p	545	99	of	of	IN
cord-012418-6ralcn8p	545	100	IFN	IFN	NNP
cord-012418-6ralcn8p	545	101	-	-	HYPH
cord-012418-6ralcn8p	545	102	beta	beta	NN
cord-012418-6ralcn8p	545	103	and	and	CC
cord-012418-6ralcn8p	545	104	IFN	IFN	NNP
cord-012418-6ralcn8p	545	105	-	-	HYPH
cord-012418-6ralcn8p	545	106	inducible	inducible	JJ
cord-012418-6ralcn8p	545	107	genes	gene	NNS
cord-012418-6ralcn8p	546	1	Regulated	regulated	JJ
cord-012418-6ralcn8p	546	2	expression	expression	NN
cord-012418-6ralcn8p	546	3	of	of	IN
cord-012418-6ralcn8p	546	4	a	a	DT
cord-012418-6ralcn8p	546	5	gene	gene	NN
cord-012418-6ralcn8p	546	6	encoding	encode	VBG
cord-012418-6ralcn8p	546	7	a	a	DT
cord-012418-6ralcn8p	546	8	nuclear	nuclear	JJ
cord-012418-6ralcn8p	546	9	factor	factor	NN
cord-012418-6ralcn8p	546	10	,	,	,
cord-012418-6ralcn8p	546	11	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	546	12	,	,	,
cord-012418-6ralcn8p	546	13	that	that	WDT
cord-012418-6ralcn8p	546	14	specifically	specifically	RB
cord-012418-6ralcn8p	546	15	binds	bind	VBZ
cord-012418-6ralcn8p	546	16	to	to	IN
cord-012418-6ralcn8p	546	17	IFN	IFN	NNP
cord-012418-6ralcn8p	546	18	-	-	HYPH
cord-012418-6ralcn8p	546	19	beta	beta	NN
cord-012418-6ralcn8p	546	20	gene	gene	NN
cord-012418-6ralcn8p	546	21	regulatory	regulatory	JJ
cord-012418-6ralcn8p	546	22	elements	element	NNS
cord-012418-6ralcn8p	547	1	Targeted	target	VBN
cord-012418-6ralcn8p	547	2	disruption	disruption	NN
cord-012418-6ralcn8p	547	3	of	of	IN
cord-012418-6ralcn8p	547	4	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	547	5	or	or	CC
cord-012418-6ralcn8p	547	6	IRF-2	IRF-2	NNP
cord-012418-6ralcn8p	547	7	results	result	VBZ
cord-012418-6ralcn8p	547	8	in	in	IN
cord-012418-6ralcn8p	547	9	abnormal	abnormal	JJ
cord-012418-6ralcn8p	547	10	type	type	NN
cord-012418-6ralcn8p	548	1	I	-PRON-	PRP
cord-012418-6ralcn8p	548	2	IFN	IFN	NNP
cord-012418-6ralcn8p	548	3	gene	gene	NN
cord-012418-6ralcn8p	548	4	induction	induction	NN
cord-012418-6ralcn8p	548	5	and	and	CC
cord-012418-6ralcn8p	548	6	aberrant	aberrant	JJ
cord-012418-6ralcn8p	548	7	lymphocyte	lymphocyte	NN
cord-012418-6ralcn8p	548	8	development	development	NN
cord-012418-6ralcn8p	548	9	Mice	mouse	NNS
cord-012418-6ralcn8p	548	10	devoid	devoid	JJ
cord-012418-6ralcn8p	548	11	of	of	IN
cord-012418-6ralcn8p	548	12	interferon	interferon	NN
cord-012418-6ralcn8p	548	13	regulatory	regulatory	JJ
cord-012418-6ralcn8p	548	14	factor	factor	NN
cord-012418-6ralcn8p	548	15	1	1	CD
cord-012418-6ralcn8p	549	1	(	(	-LRB-
cord-012418-6ralcn8p	549	2	IRF-1	IRF-1	NNP
cord-012418-6ralcn8p	549	3	)	)	-RRB-
cord-012418-6ralcn8p	549	4	show	show	VBP
cord-012418-6ralcn8p	549	5	normal	normal	JJ
cord-012418-6ralcn8p	549	6	expression	expression	NN
cord-012418-6ralcn8p	549	7	of	of	IN
cord-012418-6ralcn8p	549	8	type	type	NN
cord-012418-6ralcn8p	550	1	I	-PRON-	PRP
cord-012418-6ralcn8p	550	2	interferon	interferon	VBD
cord-012418-6ralcn8p	550	3	genes	gene	VBZ
cord-012418-6ralcn8p	550	4	Assembly	Assembly	NNP
cord-012418-6ralcn8p	550	5	of	of	IN
cord-012418-6ralcn8p	550	6	a	a	DT
cord-012418-6ralcn8p	550	7	functional	functional	JJ
cord-012418-6ralcn8p	550	8	beta	beta	NN
cord-012418-6ralcn8p	551	1	interferon	interferon	NNP
cord-012418-6ralcn8p	551	2	enhanceosome	enhanceosome	NNP
cord-012418-6ralcn8p	551	3	is	be	VBZ
cord-012418-6ralcn8p	551	4	dependent	dependent	JJ
cord-012418-6ralcn8p	551	5	on	on	IN
cord-012418-6ralcn8p	551	6	ATF-2-c	ATF-2-c	NNP
cord-012418-6ralcn8p	551	7	-	-	HYPH
cord-012418-6ralcn8p	551	8	jun	jun	NNP
cord-012418-6ralcn8p	551	9	heterodimer	heterodimer	NNP
cord-012418-6ralcn8p	551	10	orientation	orientation	NN
cord-012418-6ralcn8p	551	11	Crystal	Crystal	NNP
cord-012418-6ralcn8p	551	12	structure	structure	NN
cord-012418-6ralcn8p	551	13	of	of	IN
cord-012418-6ralcn8p	551	14	ATF-2	ATF-2	NNP
cord-012418-6ralcn8p	551	15	/	/	SYM
cord-012418-6ralcn8p	551	16	c	c	NNP
cord-012418-6ralcn8p	551	17	-	-	:
cord-012418-6ralcn8p	551	18	Jun	Jun	NNP
cord-012418-6ralcn8p	551	19	and	and	CC
cord-012418-6ralcn8p	551	20	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	551	21	bound	bind	VBD
cord-012418-6ralcn8p	551	22	to	to	IN
cord-012418-6ralcn8p	551	23	the	the	DT
cord-012418-6ralcn8p	551	24	interferon	interferon	NN
cord-012418-6ralcn8p	551	25	-	-	HYPH
cord-012418-6ralcn8p	551	26	beta	beta	NN
cord-012418-6ralcn8p	551	27	enhancer	enhancer	NN
cord-012418-6ralcn8p	551	28	Structure	Structure	NNP
cord-012418-6ralcn8p	551	29	of	of	IN
cord-012418-6ralcn8p	551	30	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	551	31	bound	bind	VBN
cord-012418-6ralcn8p	551	32	to	to	IN
cord-012418-6ralcn8p	551	33	the	the	DT
cord-012418-6ralcn8p	551	34	PRDIII	PRDIII	NNP
cord-012418-6ralcn8p	551	35	-	-	HYPH
cord-012418-6ralcn8p	551	36	I	I	NNP
cord-012418-6ralcn8p	551	37	regulatory	regulatory	JJ
cord-012418-6ralcn8p	551	38	element	element	NN
cord-012418-6ralcn8p	551	39	of	of	IN
cord-012418-6ralcn8p	551	40	the	the	DT
cord-012418-6ralcn8p	551	41	human	human	JJ
cord-012418-6ralcn8p	551	42	interferon	interferon	NN
cord-012418-6ralcn8p	551	43	-	-	HYPH
cord-012418-6ralcn8p	551	44	beta	beta	NN
cord-012418-6ralcn8p	551	45	enhancer	enhancer	NN
cord-012418-6ralcn8p	552	1	The	the	DT
cord-012418-6ralcn8p	552	2	role	role	NN
cord-012418-6ralcn8p	552	3	of	of	IN
cord-012418-6ralcn8p	552	4	response	response	NN
cord-012418-6ralcn8p	552	5	elements	element	NNS
cord-012418-6ralcn8p	552	6	organization	organization	NN
cord-012418-6ralcn8p	552	7	in	in	IN
cord-012418-6ralcn8p	552	8	transcription	transcription	NN
cord-012418-6ralcn8p	552	9	factor	factor	NN
cord-012418-6ralcn8p	552	10	selectivity	selectivity	NN
cord-012418-6ralcn8p	552	11	:	:	:
cord-012418-6ralcn8p	553	1	The	the	DT
cord-012418-6ralcn8p	553	2	IFN	IFN	NNP
cord-012418-6ralcn8p	553	3	-	-	HYPH
cord-012418-6ralcn8p	553	4	beta	beta	NNP
cord-012418-6ralcn8p	553	5	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	553	6	example	example	NN
cord-012418-6ralcn8p	554	1	Efficient	efficient	JJ
cord-012418-6ralcn8p	554	2	recruitment	recruitment	NN
cord-012418-6ralcn8p	554	3	of	of	IN
cord-012418-6ralcn8p	554	4	TFIIB	TFIIB	NNP
cord-012418-6ralcn8p	554	5	and	and	CC
cord-012418-6ralcn8p	554	6	CBP	CBP	NNP
cord-012418-6ralcn8p	554	7	-	-	HYPH
cord-012418-6ralcn8p	554	8	RNA	RNA	NNP
cord-012418-6ralcn8p	554	9	polymerase	polymerase	NN
cord-012418-6ralcn8p	554	10	II	II	NNP
cord-012418-6ralcn8p	554	11	holoenzyme	holoenzyme	NNS
cord-012418-6ralcn8p	554	12	by	by	IN
cord-012418-6ralcn8p	554	13	an	an	DT
cord-012418-6ralcn8p	554	14	interferon	interferon	NN
cord-012418-6ralcn8p	554	15	-	-	HYPH
cord-012418-6ralcn8p	554	16	beta	beta	NN
cord-012418-6ralcn8p	554	17	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	554	18	in	in	IN
cord-012418-6ralcn8p	554	19	vitro	vitro	FW
cord-012418-6ralcn8p	554	20	Virus	virus	NN
cord-012418-6ralcn8p	554	21	infection	infection	NN
cord-012418-6ralcn8p	554	22	leads	lead	VBZ
cord-012418-6ralcn8p	554	23	to	to	IN
cord-012418-6ralcn8p	554	24	localized	localized	JJ
cord-012418-6ralcn8p	554	25	hyperacetylation	hyperacetylation	NN
cord-012418-6ralcn8p	554	26	of	of	IN
cord-012418-6ralcn8p	554	27	histones	histone	NNS
cord-012418-6ralcn8p	554	28	H3	H3	NNP
cord-012418-6ralcn8p	554	29	and	and	CC
cord-012418-6ralcn8p	554	30	H4	H4	NNP
cord-012418-6ralcn8p	554	31	at	at	IN
cord-012418-6ralcn8p	554	32	the	the	DT
cord-012418-6ralcn8p	554	33	IFN	IFN	NNP
cord-012418-6ralcn8p	554	34	-	-	HYPH
cord-012418-6ralcn8p	554	35	beta	beta	NN
cord-012418-6ralcn8p	554	36	promoter	promoter	NN
cord-012418-6ralcn8p	554	37	Deciphering	decipher	VBG
cord-012418-6ralcn8p	554	38	the	the	DT
cord-012418-6ralcn8p	554	39	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	554	40	histone	histone	NNP
cord-012418-6ralcn8p	554	41	acetylation	acetylation	NNP
cord-012418-6ralcn8p	554	42	code	code	NN
cord-012418-6ralcn8p	554	43	for	for	IN
cord-012418-6ralcn8p	554	44	a	a	DT
cord-012418-6ralcn8p	554	45	human	human	JJ
cord-012418-6ralcn8p	554	46	gene	gene	NN
cord-012418-6ralcn8p	554	47	Nucleosome	Nucleosome	NNP
cord-012418-6ralcn8p	554	48	sliding	slide	VBG
cord-012418-6ralcn8p	554	49	via	via	IN
cord-012418-6ralcn8p	554	50	TBP	TBP	NNP
cord-012418-6ralcn8p	554	51	DNA	dna	NN
cord-012418-6ralcn8p	554	52	binding	binding	NN
cord-012418-6ralcn8p	554	53	in	in	IN
cord-012418-6ralcn8p	554	54	vivo	vivo	NN
cord-012418-6ralcn8p	554	55	Eukaryotic	eukaryotic	JJ
cord-012418-6ralcn8p	554	56	Transcription	Transcription	NNP
cord-012418-6ralcn8p	555	1	Turns	turn	VBZ
cord-012418-6ralcn8p	555	2	50	50	CD
cord-012418-6ralcn8p	555	3	Crystal	Crystal	NNP
cord-012418-6ralcn8p	555	4	structure	structure	NN
cord-012418-6ralcn8p	555	5	of	of	IN
cord-012418-6ralcn8p	555	6	a	a	DT
cord-012418-6ralcn8p	555	7	yeast	yeast	NN
cord-012418-6ralcn8p	555	8	TBP	TBP	NNP
cord-012418-6ralcn8p	555	9	/	/	SYM
cord-012418-6ralcn8p	555	10	TATA	TATA	NNP
cord-012418-6ralcn8p	555	11	-	-	HYPH
cord-012418-6ralcn8p	555	12	box	box	NN
cord-012418-6ralcn8p	555	13	complex	complex	JJ
cord-012418-6ralcn8p	555	14	High	high	JJ
cord-012418-6ralcn8p	555	15	-	-	HYPH
cord-012418-6ralcn8p	555	16	density	density	NN
cord-012418-6ralcn8p	555	17	nucleosome	nucleosome	NN
cord-012418-6ralcn8p	555	18	occupancy	occupancy	NN
cord-012418-6ralcn8p	555	19	map	map	NN
cord-012418-6ralcn8p	555	20	of	of	IN
cord-012418-6ralcn8p	555	21	human	human	JJ
cord-012418-6ralcn8p	555	22	chromosome	chromosome	NN
cord-012418-6ralcn8p	555	23	9p21	9p21	CD
cord-012418-6ralcn8p	555	24	-	-	SYM
cord-012418-6ralcn8p	555	25	22	22	CD
cord-012418-6ralcn8p	555	26	reveals	reveal	NNS
cord-012418-6ralcn8p	555	27	chromatin	chromatin	NN
cord-012418-6ralcn8p	555	28	organization	organization	NN
cord-012418-6ralcn8p	555	29	of	of	IN
cord-012418-6ralcn8p	555	30	the	the	DT
cord-012418-6ralcn8p	555	31	type	type	NN
cord-012418-6ralcn8p	556	1	I	-PRON-	PRP
cord-012418-6ralcn8p	556	2	interferon	interferon	RB
cord-012418-6ralcn8p	556	3	gene	gene	NN
cord-012418-6ralcn8p	556	4	cluster	cluster	NN
cord-012418-6ralcn8p	556	5	Identification	identification	NN
cord-012418-6ralcn8p	556	6	of	of	IN
cord-012418-6ralcn8p	556	7	individual	individual	JJ
cord-012418-6ralcn8p	556	8	interferon	interferon	NN
cord-012418-6ralcn8p	556	9	-	-	HYPH
cord-012418-6ralcn8p	556	10	producing	produce	VBG
cord-012418-6ralcn8p	556	11	cells	cell	NNS
cord-012418-6ralcn8p	556	12	by	by	IN
cord-012418-6ralcn8p	556	13	in	in	IN
cord-012418-6ralcn8p	556	14	situ	situ	NN
cord-012418-6ralcn8p	556	15	hybridization	hybridization	NN
cord-012418-6ralcn8p	556	16	Stochastic	stochastic	JJ
cord-012418-6ralcn8p	556	17	regulation	regulation	NN
cord-012418-6ralcn8p	556	18	in	in	IN
cord-012418-6ralcn8p	556	19	early	early	JJ
cord-012418-6ralcn8p	556	20	immune	immune	JJ
cord-012418-6ralcn8p	556	21	response	response	NN
cord-012418-6ralcn8p	557	1	Chromosome	chromosome	NN
cord-012418-6ralcn8p	557	2	-	-	HYPH
cord-012418-6ralcn8p	557	3	specific	specific	JJ
cord-012418-6ralcn8p	557	4	and	and	CC
cord-012418-6ralcn8p	557	5	noisy	noisy	JJ
cord-012418-6ralcn8p	557	6	IFNB1	ifnb1	NN
cord-012418-6ralcn8p	557	7	transcription	transcription	NN
cord-012418-6ralcn8p	557	8	in	in	IN
cord-012418-6ralcn8p	557	9	individual	individual	JJ
cord-012418-6ralcn8p	557	10	virus	virus	NN
cord-012418-6ralcn8p	557	11	-	-	HYPH
cord-012418-6ralcn8p	557	12	infected	infect	VBN
cord-012418-6ralcn8p	557	13	human	human	JJ
cord-012418-6ralcn8p	557	14	primary	primary	JJ
cord-012418-6ralcn8p	557	15	dendritic	dendritic	JJ
cord-012418-6ralcn8p	557	16	Cells	cell	NNS
cord-012418-6ralcn8p	558	1	Defining	define	VBG
cord-012418-6ralcn8p	558	2	emerging	emerge	VBG
cord-012418-6ralcn8p	558	3	roles	role	NNS
cord-012418-6ralcn8p	558	4	for	for	IN
cord-012418-6ralcn8p	558	5	NF	nf	NN
cord-012418-6ralcn8p	558	6	-	-	HYPH
cord-012418-6ralcn8p	558	7	kappaB	kappaB	NNP
cord-012418-6ralcn8p	558	8	in	in	IN
cord-012418-6ralcn8p	558	9	antivirus	antivirus	JJ
cord-012418-6ralcn8p	558	10	responses	response	NNS
cord-012418-6ralcn8p	558	11	:	:	:
cord-012418-6ralcn8p	558	12	Revisiting	revisit	VBG
cord-012418-6ralcn8p	558	13	the	the	DT
cord-012418-6ralcn8p	558	14	interferon	interferon	NN
cord-012418-6ralcn8p	558	15	-	-	HYPH
cord-012418-6ralcn8p	558	16	beta	beta	NN
cord-012418-6ralcn8p	558	17	enhanceosome	enhanceosome	NN
cord-012418-6ralcn8p	558	18	paradigm	paradigm	NN
cord-012418-6ralcn8p	558	19	Gene	Gene	NNP
cord-012418-6ralcn8p	558	20	repression	repression	NN
cord-012418-6ralcn8p	558	21	by	by	IN
cord-012418-6ralcn8p	558	22	coactivator	coactivator	NN
cord-012418-6ralcn8p	558	23	repulsion	repulsion	NN
cord-012418-6ralcn8p	559	1	The	the	DT
cord-012418-6ralcn8p	559	2	specificity	specificity	NN
cord-012418-6ralcn8p	559	3	of	of	IN
cord-012418-6ralcn8p	559	4	innate	innate	JJ
cord-012418-6ralcn8p	559	5	immune	immune	JJ
cord-012418-6ralcn8p	559	6	responses	response	NNS
cord-012418-6ralcn8p	559	7	is	be	VBZ
cord-012418-6ralcn8p	559	8	enforced	enforce	VBN
cord-012418-6ralcn8p	559	9	by	by	IN
cord-012418-6ralcn8p	559	10	repression	repression	NN
cord-012418-6ralcn8p	559	11	of	of	IN
cord-012418-6ralcn8p	559	12	interferon	interferon	NN
cord-012418-6ralcn8p	559	13	response	response	NN
cord-012418-6ralcn8p	559	14	elements	element	NNS
cord-012418-6ralcn8p	559	15	by	by	IN
cord-012418-6ralcn8p	559	16	NF	NF	NNP
cord-012418-6ralcn8p	559	17	-	-	HYPH
cord-012418-6ralcn8p	559	18	κB	κb	CD
cord-012418-6ralcn8p	559	19	p50	p50	NN
cord-012418-6ralcn8p	560	1	The	the	DT
cord-012418-6ralcn8p	560	2	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	560	3	silencer	silencer	NN
cord-012418-6ralcn8p	560	4	protein	protein	NN
cord-012418-6ralcn8p	560	5	NRF	NRF	NNP
cord-012418-6ralcn8p	560	6	:	:	:
cord-012418-6ralcn8p	561	1	A	a	DT
cord-012418-6ralcn8p	561	2	repressor	repressor	NN
cord-012418-6ralcn8p	561	3	of	of	IN
cord-012418-6ralcn8p	561	4	NF	nf	NN
cord-012418-6ralcn8p	561	5	-	-	HYPH
cord-012418-6ralcn8p	561	6	kappa	kappa	NN
cord-012418-6ralcn8p	561	7	B	B	NNP
cord-012418-6ralcn8p	561	8	enhancers	enhancer	NNS
cord-012418-6ralcn8p	561	9	Constitutive	constitutive	JJ
cord-012418-6ralcn8p	561	10	silencing	silencing	NN
cord-012418-6ralcn8p	561	11	of	of	IN
cord-012418-6ralcn8p	561	12	IFN	IFN	NNP
cord-012418-6ralcn8p	561	13	-	-	HYPH
cord-012418-6ralcn8p	561	14	beta	beta	NN
cord-012418-6ralcn8p	561	15	promoter	promoter	NN
cord-012418-6ralcn8p	561	16	is	be	VBZ
cord-012418-6ralcn8p	561	17	mediated	mediate	VBN
cord-012418-6ralcn8p	561	18	by	by	IN
cord-012418-6ralcn8p	561	19	NRF	NRF	NNP
cord-012418-6ralcn8p	561	20	(	(	-LRB-
cord-012418-6ralcn8p	561	21	NF	NF	NNP
cord-012418-6ralcn8p	561	22	-	-	HYPH
cord-012418-6ralcn8p	561	23	kappaB	kappaB	NNP
cord-012418-6ralcn8p	561	24	-	-	HYPH
cord-012418-6ralcn8p	561	25	repressing	repress	VBG
cord-012418-6ralcn8p	561	26	factor	factor	NN
cord-012418-6ralcn8p	561	27	)	)	-RRB-
cord-012418-6ralcn8p	561	28	,	,	,
cord-012418-6ralcn8p	561	29	a	a	DT
cord-012418-6ralcn8p	561	30	nuclear	nuclear	JJ
cord-012418-6ralcn8p	561	31	inhibitor	inhibitor	NN
cord-012418-6ralcn8p	561	32	of	of	IN
cord-012418-6ralcn8p	561	33	NF	NF	NNP
cord-012418-6ralcn8p	561	34	-	-	HYPH
cord-012418-6ralcn8p	561	35	kappaB	kappaB	NNP
cord-012418-6ralcn8p	561	36	Lack	lack	NN
cord-012418-6ralcn8p	561	37	of	of	IN
cord-012418-6ralcn8p	561	38	essential	essential	JJ
cord-012418-6ralcn8p	561	39	role	role	NN
cord-012418-6ralcn8p	561	40	of	of	IN
cord-012418-6ralcn8p	561	41	NF	nf	NN
cord-012418-6ralcn8p	561	42	-	-	HYPH
cord-012418-6ralcn8p	561	43	kappa	kappa	NNP
cord-012418-6ralcn8p	561	44	B	B	NNP
cord-012418-6ralcn8p	561	45	p50	p50	NNP
cord-012418-6ralcn8p	561	46	,	,	,
cord-012418-6ralcn8p	561	47	RelA	RelA	NNP
cord-012418-6ralcn8p	561	48	,	,	,
cord-012418-6ralcn8p	561	49	and	and	CC
cord-012418-6ralcn8p	561	50	cRel	cRel	NNP
cord-012418-6ralcn8p	561	51	subunits	subunit	NNS
cord-012418-6ralcn8p	561	52	in	in	IN
cord-012418-6ralcn8p	561	53	virus	virus	NN
cord-012418-6ralcn8p	561	54	-	-	HYPH
cord-012418-6ralcn8p	561	55	induced	induce	VBN
cord-012418-6ralcn8p	561	56	type	type	NN
cord-012418-6ralcn8p	561	57	1	1	CD
cord-012418-6ralcn8p	561	58	IFN	IFN	NNP
cord-012418-6ralcn8p	561	59	expression	expression	NN
cord-012418-6ralcn8p	561	60	Distinct	distinct	JJ
cord-012418-6ralcn8p	561	61	roles	role	NNS
cord-012418-6ralcn8p	561	62	for	for	IN
cord-012418-6ralcn8p	561	63	the	the	DT
cord-012418-6ralcn8p	561	64	NF	nf	NN
cord-012418-6ralcn8p	561	65	-	-	HYPH
cord-012418-6ralcn8p	561	66	kappa	kappa	NN
cord-012418-6ralcn8p	561	67	B	B	NNP
cord-012418-6ralcn8p	561	68	RelA	RelA	NNP
cord-012418-6ralcn8p	561	69	subunit	subunit	NN
cord-012418-6ralcn8p	561	70	during	during	IN
cord-012418-6ralcn8p	561	71	antiviral	antiviral	JJ
cord-012418-6ralcn8p	561	72	innate	innate	JJ
cord-012418-6ralcn8p	561	73	immune	immune	JJ
cord-012418-6ralcn8p	561	74	responses	response	NNS
cord-012418-6ralcn8p	562	1	NF	nf	NN
cord-012418-6ralcn8p	562	2	-	-	HYPH
cord-012418-6ralcn8p	562	3	kappa	kappa	NN
cord-012418-6ralcn8p	562	4	B	B	NNP
cord-012418-6ralcn8p	562	5	RelA	RelA	NNP
cord-012418-6ralcn8p	562	6	subunit	subunit	NN
cord-012418-6ralcn8p	562	7	is	be	VBZ
cord-012418-6ralcn8p	562	8	crucial	crucial	JJ
cord-012418-6ralcn8p	562	9	for	for	IN
cord-012418-6ralcn8p	562	10	early	early	JJ
cord-012418-6ralcn8p	562	11	IFN	IFN	NNP
cord-012418-6ralcn8p	562	12	-	-	HYPH
cord-012418-6ralcn8p	562	13	beta	beta	NN
cord-012418-6ralcn8p	562	14	expression	expression	NN
cord-012418-6ralcn8p	562	15	and	and	CC
cord-012418-6ralcn8p	562	16	resistance	resistance	NN
cord-012418-6ralcn8p	562	17	to	to	IN
cord-012418-6ralcn8p	562	18	RNA	RNA	NNP
cord-012418-6ralcn8p	562	19	virus	virus	NN
cord-012418-6ralcn8p	562	20	replication	replication	NN
cord-012418-6ralcn8p	562	21	Association	Association	NNP
cord-012418-6ralcn8p	562	22	of	of	IN
cord-012418-6ralcn8p	562	23	the	the	DT
cord-012418-6ralcn8p	562	24	interferon	interferon	NNP
cord-012418-6ralcn8p	562	25	-	-	HYPH
cord-012418-6ralcn8p	562	26	β	β	NN
cord-012418-6ralcn8p	562	27	gene	gene	NN
cord-012418-6ralcn8p	562	28	with	with	IN
cord-012418-6ralcn8p	562	29	pericentromeric	pericentromeric	NNP
cord-012418-6ralcn8p	562	30	heterochromatin	heterochromatin	NN
cord-012418-6ralcn8p	562	31	is	be	VBZ
cord-012418-6ralcn8p	562	32	dynamically	dynamically	RB
cord-012418-6ralcn8p	562	33	regulated	regulate	VBN
cord-012418-6ralcn8p	562	34	during	during	IN
cord-012418-6ralcn8p	562	35	virus	virus	NN
cord-012418-6ralcn8p	562	36	infection	infection	NN
cord-012418-6ralcn8p	562	37	through	through	IN
cord-012418-6ralcn8p	562	38	a	a	DT
cord-012418-6ralcn8p	562	39	YY1-dependent	yy1-dependent	NN
cord-012418-6ralcn8p	562	40	mechanism	mechanism	NN
cord-012418-6ralcn8p	562	41	Yin	Yin	NNP
cord-012418-6ralcn8p	562	42	Yang	Yang	NNP
cord-012418-6ralcn8p	562	43	1	1	CD
cord-012418-6ralcn8p	563	1	Dynamically	dynamically	RB
cord-012418-6ralcn8p	563	2	Regulates	regulate	VBZ
cord-012418-6ralcn8p	563	3	Antiviral	antiviral	JJ
cord-012418-6ralcn8p	563	4	Innate	Innate	NNP
cord-012418-6ralcn8p	563	5	Immune	immune	JJ
cord-012418-6ralcn8p	563	6	Responses	response	NNS
cord-012418-6ralcn8p	564	1	During	during	IN
cord-012418-6ralcn8p	564	2	Viral	Viral	NNP
cord-012418-6ralcn8p	564	3	Infection	Infection	NNP
cord-012418-6ralcn8p	564	4	Enhanceosome	Enhanceosome	NNP
cord-012418-6ralcn8p	564	5	formation	formation	NN
cord-012418-6ralcn8p	564	6	over	over	IN
cord-012418-6ralcn8p	564	7	the	the	DT
cord-012418-6ralcn8p	564	8	beta	beta	NN
cord-012418-6ralcn8p	564	9	interferon	interferon	NN
cord-012418-6ralcn8p	564	10	promoter	promoter	NN
cord-012418-6ralcn8p	564	11	underlies	underlie	VBZ
cord-012418-6ralcn8p	564	12	a	a	DT
cord-012418-6ralcn8p	564	13	remote	remote	JJ
cord-012418-6ralcn8p	564	14	-	-	HYPH
cord-012418-6ralcn8p	564	15	control	control	NN
cord-012418-6ralcn8p	564	16	mechanism	mechanism	NN
cord-012418-6ralcn8p	564	17	mediated	mediate	VBN
cord-012418-6ralcn8p	564	18	by	by	IN
cord-012418-6ralcn8p	564	19	YY1	YY1	NNP
cord-012418-6ralcn8p	564	20	and	and	CC
cord-012418-6ralcn8p	564	21	YY2	YY2	NNP
cord-012418-6ralcn8p	564	22	Transcription	Transcription	NNP
cord-012418-6ralcn8p	564	23	factor	factor	NN
cord-012418-6ralcn8p	564	24	YY1	YY1	NNP
cord-012418-6ralcn8p	564	25	binds	bind	VBZ
cord-012418-6ralcn8p	564	26	to	to	IN
cord-012418-6ralcn8p	564	27	the	the	DT
cord-012418-6ralcn8p	564	28	murine	murine	JJ
cord-012418-6ralcn8p	564	29	beta	beta	NN
cord-012418-6ralcn8p	564	30	interferon	interferon	NN
cord-012418-6ralcn8p	564	31	promoter	promoter	NN
cord-012418-6ralcn8p	564	32	and	and	CC
cord-012418-6ralcn8p	564	33	regulates	regulate	VBZ
cord-012418-6ralcn8p	564	34	its	-PRON-	PRP$
cord-012418-6ralcn8p	564	35	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	564	36	capacity	capacity	NN
cord-012418-6ralcn8p	564	37	with	with	IN
cord-012418-6ralcn8p	564	38	a	a	DT
cord-012418-6ralcn8p	564	39	dual	dual	JJ
cord-012418-6ralcn8p	564	40	activator	activator	NN
cord-012418-6ralcn8p	564	41	/	/	SYM
cord-012418-6ralcn8p	564	42	repressor	repressor	NN
cord-012418-6ralcn8p	564	43	role	role	NN
cord-012418-6ralcn8p	564	44	Binding	Binding	NNP
cord-012418-6ralcn8p	564	45	of	of	IN
cord-012418-6ralcn8p	564	46	YY1	YY1	NNP
cord-012418-6ralcn8p	564	47	to	to	IN
cord-012418-6ralcn8p	564	48	the	the	DT
cord-012418-6ralcn8p	564	49	proximal	proximal	JJ
cord-012418-6ralcn8p	564	50	region	region	NN
cord-012418-6ralcn8p	564	51	of	of	IN
cord-012418-6ralcn8p	564	52	the	the	DT
cord-012418-6ralcn8p	564	53	murine	murine	JJ
cord-012418-6ralcn8p	564	54	beta	beta	NN
cord-012418-6ralcn8p	564	55	interferon	interferon	NN
cord-012418-6ralcn8p	564	56	promoter	promoter	NN
cord-012418-6ralcn8p	565	1	is	be	VBZ
cord-012418-6ralcn8p	565	2	essential	essential	JJ
cord-012418-6ralcn8p	565	3	to	to	TO
cord-012418-6ralcn8p	565	4	allow	allow	VB
cord-012418-6ralcn8p	565	5	CBP	CBP	NNP
cord-012418-6ralcn8p	565	6	recruitment	recruitment	NN
cord-012418-6ralcn8p	565	7	and	and	CC
cord-012418-6ralcn8p	565	8	K8H4	K8H4	NNP
cord-012418-6ralcn8p	565	9	/	/	SYM
cord-012418-6ralcn8p	565	10	K14H3	K14H3	NNP
cord-012418-6ralcn8p	565	11	acetylation	acetylation	NN
cord-012418-6ralcn8p	565	12	on	on	IN
cord-012418-6ralcn8p	565	13	the	the	DT
cord-012418-6ralcn8p	565	14	promoter	promoter	NN
cord-012418-6ralcn8p	565	15	region	region	NN
cord-012418-6ralcn8p	565	16	after	after	IN
cord-012418-6ralcn8p	565	17	virus	virus	NN
cord-012418-6ralcn8p	565	18	infection	infection	NN
cord-012418-6ralcn8p	566	1	A	a	DT
cord-012418-6ralcn8p	566	2	novel	novel	JJ
cord-012418-6ralcn8p	566	3	virus	virus	NN
cord-012418-6ralcn8p	566	4	-	-	HYPH
cord-012418-6ralcn8p	566	5	inducible	inducible	JJ
cord-012418-6ralcn8p	566	6	enhancer	enhancer	NN
cord-012418-6ralcn8p	566	7	of	of	IN
cord-012418-6ralcn8p	566	8	the	the	DT
cord-012418-6ralcn8p	566	9	interferon	interferon	NN
cord-012418-6ralcn8p	566	10	-	-	HYPH
cord-012418-6ralcn8p	566	11	β	β	NN
cord-012418-6ralcn8p	566	12	gene	gene	NN
cord-012418-6ralcn8p	566	13	with	with	IN
cord-012418-6ralcn8p	566	14	tightly	tightly	RB
cord-012418-6ralcn8p	566	15	linked	link	VBN
cord-012418-6ralcn8p	566	16	promoter	promoter	NN
cord-012418-6ralcn8p	566	17	and	and	CC
cord-012418-6ralcn8p	566	18	enhancer	enhancer	NN
cord-012418-6ralcn8p	566	19	activities	activity	NNS
cord-012418-6ralcn8p	566	20	Activation	activation	NN
cord-012418-6ralcn8p	566	21	and	and	CC
cord-012418-6ralcn8p	566	22	regulation	regulation	NN
cord-012418-6ralcn8p	566	23	of	of	IN
cord-012418-6ralcn8p	566	24	interferon	interferon	NN
cord-012418-6ralcn8p	566	25	-	-	HYPH
cord-012418-6ralcn8p	566	26	β	β	NN
cord-012418-6ralcn8p	566	27	in	in	IN
cord-012418-6ralcn8p	566	28	immune	immune	JJ
cord-012418-6ralcn8p	566	29	responses	response	NNS
cord-012418-6ralcn8p	567	1	Post	post	JJ
cord-012418-6ralcn8p	567	2	-	-	JJ
cord-012418-6ralcn8p	567	3	translational	translational	JJ
cord-012418-6ralcn8p	567	4	regulation	regulation	NN
cord-012418-6ralcn8p	567	5	of	of	IN
cord-012418-6ralcn8p	567	6	antiviral	antiviral	JJ
cord-012418-6ralcn8p	567	7	innate	innate	NN
cord-012418-6ralcn8p	567	8	signaling	signal	VBG
cord-012418-6ralcn8p	567	9	Protein	Protein	NNP
cord-012418-6ralcn8p	567	10	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	567	11	PP1	PP1	NNP
cord-012418-6ralcn8p	567	12	negatively	negatively	RB
cord-012418-6ralcn8p	567	13	regulates	regulate	VBZ
cord-012418-6ralcn8p	567	14	the	the	DT
cord-012418-6ralcn8p	567	15	Toll	Toll	NNP
cord-012418-6ralcn8p	567	16	-	-	HYPH
cord-012418-6ralcn8p	567	17	like	like	JJ
cord-012418-6ralcn8p	567	18	receptor	receptor	NN
cord-012418-6ralcn8p	567	19	-	-	:
cord-012418-6ralcn8p	567	20	and	and	CC
cord-012418-6ralcn8p	567	21	RIG	rig	NN
cord-012418-6ralcn8p	567	22	-	-	HYPH
cord-012418-6ralcn8p	567	23	I	-PRON-	PRP
cord-012418-6ralcn8p	567	24	-	-	HYPH
cord-012418-6ralcn8p	567	25	like	like	JJ
cord-012418-6ralcn8p	567	26	receptor	receptor	NN
cord-012418-6ralcn8p	567	27	-	-	HYPH
cord-012418-6ralcn8p	567	28	triggered	trigger	VBN
cord-012418-6ralcn8p	567	29	production	production	NN
cord-012418-6ralcn8p	567	30	of	of	IN
cord-012418-6ralcn8p	567	31	type	type	NN
cord-012418-6ralcn8p	568	1	I	-PRON-	PRP
cord-012418-6ralcn8p	568	2	interferon	interferon	RB
cord-012418-6ralcn8p	568	3	by	by	IN
cord-012418-6ralcn8p	568	4	inhibiting	inhibit	VBG
cord-012418-6ralcn8p	568	5	IRF3	IRF3	NNP
cord-012418-6ralcn8p	568	6	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	568	7	at	at	IN
cord-012418-6ralcn8p	568	8	serines	serines	NNPS
cord-012418-6ralcn8p	568	9	396	396	CD
cord-012418-6ralcn8p	568	10	and	and	CC
cord-012418-6ralcn8p	568	11	385	385	CD
cord-012418-6ralcn8p	568	12	in	in	IN
cord-012418-6ralcn8p	568	13	macrophage	macrophage	NN
cord-012418-6ralcn8p	569	1	The	the	DT
cord-012418-6ralcn8p	569	2	methyltransferase	methyltransferase	NN
cord-012418-6ralcn8p	569	3	NSD3	NSD3	NNP
cord-012418-6ralcn8p	569	4	promotes	promote	VBZ
cord-012418-6ralcn8p	569	5	antiviral	antiviral	JJ
cord-012418-6ralcn8p	569	6	innate	innate	JJ
cord-012418-6ralcn8p	569	7	immunity	immunity	NN
cord-012418-6ralcn8p	569	8	via	via	IN
cord-012418-6ralcn8p	569	9	direct	direct	JJ
cord-012418-6ralcn8p	569	10	lysine	lysine	NN
cord-012418-6ralcn8p	569	11	methylation	methylation	NN
cord-012418-6ralcn8p	569	12	of	of	IN
cord-012418-6ralcn8p	569	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	570	1	Interferon	interferon	NN
cord-012418-6ralcn8p	570	2	-	-	HYPH
cord-012418-6ralcn8p	570	3	inducible	inducible	JJ
cord-012418-6ralcn8p	570	4	cytoplasmic	cytoplasmic	JJ
cord-012418-6ralcn8p	570	5	lncLrrc55-AS	lnclrrc55-as	NN
cord-012418-6ralcn8p	570	6	promotes	promote	VBZ
cord-012418-6ralcn8p	570	7	antiviral	antiviral	JJ
cord-012418-6ralcn8p	570	8	innate	innate	JJ
cord-012418-6ralcn8p	570	9	responses	response	NNS
cord-012418-6ralcn8p	570	10	by	by	IN
cord-012418-6ralcn8p	570	11	strengthening	strengthen	VBG
cord-012418-6ralcn8p	570	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	570	13	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	570	14	Recruitment	Recruitment	NNP
cord-012418-6ralcn8p	570	15	of	of	IN
cord-012418-6ralcn8p	570	16	phosphatase	phosphatase	NN
cord-012418-6ralcn8p	570	17	PP2A	PP2A	NNS
cord-012418-6ralcn8p	570	18	by	by	IN
cord-012418-6ralcn8p	571	1	RACK1	rack1	NN
cord-012418-6ralcn8p	571	2	adaptor	adaptor	NN
cord-012418-6ralcn8p	571	3	protein	protein	NN
cord-012418-6ralcn8p	571	4	deactivates	deactivate	VBZ
cord-012418-6ralcn8p	571	5	transcription	transcription	NN
cord-012418-6ralcn8p	571	6	factor	factor	NN
cord-012418-6ralcn8p	571	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	571	8	and	and	CC
cord-012418-6ralcn8p	571	9	limits	limit	VBZ
cord-012418-6ralcn8p	571	10	type	type	NN
cord-012418-6ralcn8p	571	11	I	-PRON-	PRP
cord-012418-6ralcn8p	571	12	interferon	interferon	NN
cord-012418-6ralcn8p	571	13	signaling	signal	VBG
cord-012418-6ralcn8p	571	14	PP2A	PP2A	NNS
cord-012418-6ralcn8p	572	1	Facilitates	facilitate	VBZ
cord-012418-6ralcn8p	572	2	Porcine	porcine	JJ
cord-012418-6ralcn8p	572	3	Reproductive	reproductive	JJ
cord-012418-6ralcn8p	572	4	and	and	CC
cord-012418-6ralcn8p	572	5	Respiratory	respiratory	JJ
cord-012418-6ralcn8p	572	6	Syndrome	Syndrome	NNP
cord-012418-6ralcn8p	572	7	Virus	virus	NN
cord-012418-6ralcn8p	572	8	Replication	Replication	NNP
cord-012418-6ralcn8p	572	9	by	by	IN
cord-012418-6ralcn8p	572	10	Deactivating	deactivate	VBG
cord-012418-6ralcn8p	572	11	irf3	irf3	NNP
cord-012418-6ralcn8p	572	12	and	and	CC
cord-012418-6ralcn8p	572	13	Limiting	Limiting	NNP
cord-012418-6ralcn8p	572	14	Type	type	NN
cord-012418-6ralcn8p	573	1	I	-PRON-	PRP
cord-012418-6ralcn8p	574	1	Interferon	interferon	NN
cord-012418-6ralcn8p	574	2	Production	production	NN
cord-012418-6ralcn8p	574	3	ISG15	isg15	NN
cord-012418-6ralcn8p	574	4	enhances	enhance	VBZ
cord-012418-6ralcn8p	574	5	the	the	DT
cord-012418-6ralcn8p	574	6	innate	innate	JJ
cord-012418-6ralcn8p	574	7	antiviral	antiviral	JJ
cord-012418-6ralcn8p	574	8	response	response	NN
cord-012418-6ralcn8p	574	9	by	by	IN
cord-012418-6ralcn8p	574	10	inhibition	inhibition	NN
cord-012418-6ralcn8p	574	11	of	of	IN
cord-012418-6ralcn8p	574	12	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	574	13	degradation	degradation	NN
cord-012418-6ralcn8p	574	14	Positive	positive	JJ
cord-012418-6ralcn8p	574	15	regulation	regulation	NN
cord-012418-6ralcn8p	574	16	of	of	IN
cord-012418-6ralcn8p	574	17	interferon	interferon	NN
cord-012418-6ralcn8p	574	18	regulatory	regulatory	JJ
cord-012418-6ralcn8p	574	19	factor	factor	NN
cord-012418-6ralcn8p	574	20	3	3	CD
cord-012418-6ralcn8p	574	21	activation	activation	NN
cord-012418-6ralcn8p	574	22	by	by	IN
cord-012418-6ralcn8p	574	23	Herc5	Herc5	NNP
cord-012418-6ralcn8p	575	1	via	via	IN
cord-012418-6ralcn8p	575	2	ISG15	ISG15	NNP
cord-012418-6ralcn8p	575	3	modification	modification	NN
cord-012418-6ralcn8p	576	1	Negative	negative	JJ
cord-012418-6ralcn8p	576	2	regulation	regulation	NN
cord-012418-6ralcn8p	576	3	of	of	IN
cord-012418-6ralcn8p	576	4	interferon	interferon	NN
cord-012418-6ralcn8p	576	5	-	-	HYPH
cord-012418-6ralcn8p	576	6	regulatory	regulatory	JJ
cord-012418-6ralcn8p	576	7	factor	factor	NN
cord-012418-6ralcn8p	576	8	3-dependent	3-dependent	CD
cord-012418-6ralcn8p	576	9	innate	innate	JJ
cord-012418-6ralcn8p	576	10	antiviral	antiviral	JJ
cord-012418-6ralcn8p	576	11	response	response	NN
cord-012418-6ralcn8p	576	12	by	by	IN
cord-012418-6ralcn8p	576	13	the	the	DT
cord-012418-6ralcn8p	576	14	prolyl	prolyl	NNP
cord-012418-6ralcn8p	576	15	isomerase	isomerase	NN
cord-012418-6ralcn8p	577	1	Pin1	Pin1	NNP
cord-012418-6ralcn8p	577	2	YAP	YAP	NNP
cord-012418-6ralcn8p	577	3	antagonizes	antagonize	VBZ
cord-012418-6ralcn8p	577	4	innate	innate	JJ
cord-012418-6ralcn8p	577	5	antiviral	antiviral	JJ
cord-012418-6ralcn8p	577	6	immunity	immunity	NN
cord-012418-6ralcn8p	577	7	and	and	CC
cord-012418-6ralcn8p	577	8	is	be	VBZ
cord-012418-6ralcn8p	577	9	targeted	target	VBN
cord-012418-6ralcn8p	577	10	for	for	IN
cord-012418-6ralcn8p	577	11	lysosomal	lysosomal	JJ
cord-012418-6ralcn8p	577	12	degradation	degradation	NN
cord-012418-6ralcn8p	577	13	through	through	IN
cord-012418-6ralcn8p	577	14	IKKε	IKKε	NNS
cord-012418-6ralcn8p	577	15	-	-	HYPH
cord-012418-6ralcn8p	577	16	mediated	mediate	VBN
cord-012418-6ralcn8p	577	17	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	578	1	The	the	DT
cord-012418-6ralcn8p	578	2	tumor	tumor	NN
cord-012418-6ralcn8p	578	3	suppressor	suppressor	NN
cord-012418-6ralcn8p	578	4	PTEN	PTEN	NNP
cord-012418-6ralcn8p	578	5	has	have	VBZ
cord-012418-6ralcn8p	578	6	a	a	DT
cord-012418-6ralcn8p	578	7	critical	critical	JJ
cord-012418-6ralcn8p	578	8	role	role	NN
cord-012418-6ralcn8p	578	9	in	in	IN
cord-012418-6ralcn8p	578	10	antiviral	antiviral	JJ
cord-012418-6ralcn8p	578	11	innate	innate	NN
cord-012418-6ralcn8p	578	12	Immunity	immunity	NN
cord-012418-6ralcn8p	579	1	Interferon	interferon	NN
cord-012418-6ralcn8p	579	2	regulatory	regulatory	JJ
cord-012418-6ralcn8p	579	3	factor-3	factor-3	NNP
cord-012418-6ralcn8p	579	4	is	be	VBZ
cord-012418-6ralcn8p	579	5	an	an	DT
cord-012418-6ralcn8p	579	6	in	in	IN
cord-012418-6ralcn8p	579	7	vivo	vivo	NN
cord-012418-6ralcn8p	579	8	target	target	NN
cord-012418-6ralcn8p	579	9	of	of	IN
cord-012418-6ralcn8p	579	10	DNA	dna	NN
cord-012418-6ralcn8p	579	11	-	-	HYPH
cord-012418-6ralcn8p	579	12	PK	PK	NNP
cord-012418-6ralcn8p	579	13	S	S	NNP
cord-012418-6ralcn8p	579	14	-	-	HYPH
cord-012418-6ralcn8p	579	15	glutathionylation	glutathionylation	NN
cord-012418-6ralcn8p	579	16	of	of	IN
cord-012418-6ralcn8p	579	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	579	18	regulates	regulate	VBZ
cord-012418-6ralcn8p	579	19	IRF3-CBP	irf3-cbp	POS
cord-012418-6ralcn8p	579	20	interaction	interaction	NN
cord-012418-6ralcn8p	579	21	and	and	CC
cord-012418-6ralcn8p	579	22	activation	activation	NN
cord-012418-6ralcn8p	579	23	of	of	IN
cord-012418-6ralcn8p	579	24	the	the	DT
cord-012418-6ralcn8p	579	25	IFN	IFN	NNP
cord-012418-6ralcn8p	579	26	beta	beta	NN
cord-012418-6ralcn8p	579	27	pathway	pathway	NN
cord-012418-6ralcn8p	579	28	Pivotal	pivotal	JJ
cord-012418-6ralcn8p	579	29	role	role	NN
cord-012418-6ralcn8p	579	30	for	for	IN
cord-012418-6ralcn8p	579	31	the	the	DT
cord-012418-6ralcn8p	579	32	ESCRT	ESCRT	NNP
cord-012418-6ralcn8p	579	33	-	-	HYPH
cord-012418-6ralcn8p	579	34	II	II	NNP
cord-012418-6ralcn8p	579	35	complex	complex	JJ
cord-012418-6ralcn8p	579	36	subunit	subunit	NN
cord-012418-6ralcn8p	579	37	EAP30	EAP30	NNP
cord-012418-6ralcn8p	579	38	/	/	SYM
cord-012418-6ralcn8p	579	39	SNF8	SNF8	NNP
cord-012418-6ralcn8p	579	40	in	in	IN
cord-012418-6ralcn8p	579	41	IRF3-dependent	IRF3-dependent	NNP
cord-012418-6ralcn8p	580	1	innate	innate	JJ
cord-012418-6ralcn8p	580	2	antiviral	antiviral	JJ
cord-012418-6ralcn8p	580	3	defense	defense	NN
cord-012418-6ralcn8p	580	4	AGO2	AGO2	NNP
cord-012418-6ralcn8p	580	5	Negatively	negatively	RB
cord-012418-6ralcn8p	580	6	Regulates	regulate	VBZ
cord-012418-6ralcn8p	580	7	Type	type	NN
cord-012418-6ralcn8p	580	8	I	-PRON-	PRP
cord-012418-6ralcn8p	580	9	Interferon	interferon	NN
cord-012418-6ralcn8p	580	10	Signaling	Signaling	NNP
cord-012418-6ralcn8p	580	11	Pathway	Pathway	NNP
cord-012418-6ralcn8p	580	12	by	by	IN
cord-012418-6ralcn8p	580	13	Competition	Competition	NNP
cord-012418-6ralcn8p	580	14	Binding	Binding	NNP
cord-012418-6ralcn8p	580	15	IRF3	IRF3	NNP
cord-012418-6ralcn8p	580	16	with	with	IN
cord-012418-6ralcn8p	580	17	CBP	CBP	NNP
cord-012418-6ralcn8p	580	18	/	/	SYM
cord-012418-6ralcn8p	580	19	p300	p300	NNP
cord-012418-6ralcn8p	580	20	ELF4	ELF4	NNP
cord-012418-6ralcn8p	580	21	is	be	VBZ
cord-012418-6ralcn8p	580	22	critical	critical	JJ
cord-012418-6ralcn8p	580	23	for	for	IN
cord-012418-6ralcn8p	580	24	induction	induction	NN
cord-012418-6ralcn8p	580	25	of	of	IN
cord-012418-6ralcn8p	580	26	type	type	NN
cord-012418-6ralcn8p	581	1	I	-PRON-	PRP
cord-012418-6ralcn8p	581	2	interferon	interferon	VBD
cord-012418-6ralcn8p	581	3	and	and	CC
cord-012418-6ralcn8p	581	4	the	the	DT
cord-012418-6ralcn8p	581	5	host	host	NN
cord-012418-6ralcn8p	581	6	antiviral	antiviral	JJ
cord-012418-6ralcn8p	581	7	response	response	NN
cord-012418-6ralcn8p	581	8	IRF8	IRF8	NNP
cord-012418-6ralcn8p	581	9	and	and	CC
cord-012418-6ralcn8p	581	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	581	11	cooperatively	cooperatively	RB
cord-012418-6ralcn8p	581	12	regulate	regulate	VBP
cord-012418-6ralcn8p	581	13	rapid	rapid	JJ
cord-012418-6ralcn8p	581	14	interferon	interferon	NN
cord-012418-6ralcn8p	581	15	-	-	HYPH
cord-012418-6ralcn8p	581	16	beta	beta	NN
cord-012418-6ralcn8p	581	17	induction	induction	NN
cord-012418-6ralcn8p	581	18	in	in	IN
cord-012418-6ralcn8p	581	19	human	human	JJ
cord-012418-6ralcn8p	581	20	blood	blood	NN
cord-012418-6ralcn8p	581	21	monocytes	monocyte	NNS
cord-012418-6ralcn8p	582	1	The	the	DT
cord-012418-6ralcn8p	582	2	ubiquitin	ubiquitin	JJ
cord-012418-6ralcn8p	582	3	E3	e3	NN
cord-012418-6ralcn8p	582	4	ligase	ligase	NN
cord-012418-6ralcn8p	582	5	RAUL	RAUL	NNP
cord-012418-6ralcn8p	582	6	negatively	negatively	RB
cord-012418-6ralcn8p	582	7	regulates	regulate	VBZ
cord-012418-6ralcn8p	582	8	type	type	NN
cord-012418-6ralcn8p	582	9	i	i	PRP
cord-012418-6ralcn8p	582	10	interferon	interferon	VBD
cord-012418-6ralcn8p	582	11	through	through	IN
cord-012418-6ralcn8p	582	12	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	582	13	of	of	IN
cord-012418-6ralcn8p	582	14	the	the	DT
cord-012418-6ralcn8p	582	15	transcription	transcription	NN
cord-012418-6ralcn8p	582	16	factors	factor	NNS
cord-012418-6ralcn8p	582	17	IRF7	IRF7	NNP
cord-012418-6ralcn8p	582	18	and	and	CC
cord-012418-6ralcn8p	582	19	IRF3	IRF3	NNP
cord-012418-6ralcn8p	583	1	The	the	DT
cord-012418-6ralcn8p	583	2	E3	e3	NN
cord-012418-6ralcn8p	583	3	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	583	4	ligase	ligase	NN
cord-012418-6ralcn8p	583	5	Ro52	ro52	NN
cord-012418-6ralcn8p	583	6	negatively	negatively	RB
cord-012418-6ralcn8p	583	7	regulates	regulate	VBZ
cord-012418-6ralcn8p	583	8	IFN	IFN	NNP
cord-012418-6ralcn8p	583	9	-	-	HYPH
cord-012418-6ralcn8p	583	10	beta	beta	NN
cord-012418-6ralcn8p	583	11	production	production	NN
cord-012418-6ralcn8p	583	12	post	post	JJ
cord-012418-6ralcn8p	583	13	-	-	JJ
cord-012418-6ralcn8p	583	14	pathogen	pathogen	NN
cord-012418-6ralcn8p	583	15	recognition	recognition	NN
cord-012418-6ralcn8p	583	16	by	by	IN
cord-012418-6ralcn8p	583	17	polyubiquitin	polyubiquitin	NNS
cord-012418-6ralcn8p	583	18	-	-	HYPH
cord-012418-6ralcn8p	583	19	mediated	mediate	VBN
cord-012418-6ralcn8p	583	20	degradation	degradation	NN
cord-012418-6ralcn8p	583	21	of	of	IN
cord-012418-6ralcn8p	583	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	584	1	TRIM21	TRIM21	NNP
cord-012418-6ralcn8p	584	2	is	be	VBZ
cord-012418-6ralcn8p	584	3	essential	essential	JJ
cord-012418-6ralcn8p	584	4	to	to	TO
cord-012418-6ralcn8p	584	5	sustain	sustain	VB
cord-012418-6ralcn8p	584	6	IFN	IFN	NNP
cord-012418-6ralcn8p	584	7	regulatory	regulatory	JJ
cord-012418-6ralcn8p	584	8	factor	factor	NN
cord-012418-6ralcn8p	584	9	3	3	CD
cord-012418-6ralcn8p	584	10	activation	activation	NN
cord-012418-6ralcn8p	584	11	during	during	IN
cord-012418-6ralcn8p	584	12	antiviral	antiviral	JJ
cord-012418-6ralcn8p	584	13	response	response	NN
cord-012418-6ralcn8p	584	14	SENP2	senp2	RB
cord-012418-6ralcn8p	584	15	negatively	negatively	RB
cord-012418-6ralcn8p	584	16	regulates	regulate	VBZ
cord-012418-6ralcn8p	584	17	cellular	cellular	JJ
cord-012418-6ralcn8p	584	18	antiviral	antiviral	JJ
cord-012418-6ralcn8p	584	19	response	response	NN
cord-012418-6ralcn8p	584	20	by	by	IN
cord-012418-6ralcn8p	584	21	deSUMOylating	deSUMOylating	NNP
cord-012418-6ralcn8p	584	22	IRF3	IRF3	NNP
cord-012418-6ralcn8p	584	23	and	and	CC
cord-012418-6ralcn8p	584	24	conditioning	condition	VBG
cord-012418-6ralcn8p	584	25	it	-PRON-	PRP
cord-012418-6ralcn8p	584	26	for	for	IN
cord-012418-6ralcn8p	584	27	ubiquitination	ubiquitination	NN
cord-012418-6ralcn8p	584	28	and	and	CC
cord-012418-6ralcn8p	584	29	degradation	degradation	NN
cord-012418-6ralcn8p	584	30	Virus	virus	NN
cord-012418-6ralcn8p	584	31	infection	infection	NN
cord-012418-6ralcn8p	584	32	triggers	trigger	VBZ
cord-012418-6ralcn8p	584	33	SUMOylation	sumoylation	NN
cord-012418-6ralcn8p	584	34	of	of	IN
cord-012418-6ralcn8p	584	35	IRF3	IRF3	NNP
cord-012418-6ralcn8p	584	36	and	and	CC
cord-012418-6ralcn8p	584	37	IRF7	IRF7	NNP
cord-012418-6ralcn8p	584	38	,	,	,
cord-012418-6ralcn8p	584	39	leading	lead	VBG
cord-012418-6ralcn8p	584	40	to	to	IN
cord-012418-6ralcn8p	584	41	the	the	DT
cord-012418-6ralcn8p	584	42	negative	negative	JJ
cord-012418-6ralcn8p	584	43	regulation	regulation	NN
cord-012418-6ralcn8p	584	44	of	of	IN
cord-012418-6ralcn8p	584	45	type	type	NN
cord-012418-6ralcn8p	585	1	I	-PRON-	PRP
cord-012418-6ralcn8p	585	2	interferon	interferon	RB
cord-012418-6ralcn8p	585	3	gene	gene	NN
cord-012418-6ralcn8p	585	4	expression	expression	NN
cord-012418-6ralcn8p	586	1	Mst1	Mst1	NNP
cord-012418-6ralcn8p	586	2	shuts	shut	VBZ
cord-012418-6ralcn8p	586	3	off	off	RP
cord-012418-6ralcn8p	586	4	cytosolic	cytosolic	JJ
cord-012418-6ralcn8p	586	5	antiviral	antiviral	JJ
cord-012418-6ralcn8p	586	6	defense	defense	NN
cord-012418-6ralcn8p	586	7	through	through	IN
cord-012418-6ralcn8p	586	8	IRF3	IRF3	NNP
cord-012418-6ralcn8p	586	9	phosphorylation	phosphorylation	NN
cord-012418-6ralcn8p	587	1	Fas	Fas	NNP
cord-012418-6ralcn8p	587	2	-	-	HYPH
cord-012418-6ralcn8p	587	3	Associated	Associated	NNP
cord-012418-6ralcn8p	587	4	Factor	Factor	NNP
cord-012418-6ralcn8p	587	5	1	1	CD
cord-012418-6ralcn8p	587	6	Negatively	negatively	RB
cord-012418-6ralcn8p	587	7	Regulates	regulate	VBZ
cord-012418-6ralcn8p	587	8	the	the	DT
cord-012418-6ralcn8p	587	9	Antiviral	Antiviral	NNP
cord-012418-6ralcn8p	587	10	Immune	Immune	NNP
cord-012418-6ralcn8p	587	11	Response	response	NN
cord-012418-6ralcn8p	587	12	by	by	IN
cord-012418-6ralcn8p	587	13	Inhibiting	inhibit	VBG
cord-012418-6ralcn8p	587	14	Translocation	Translocation	NNP
cord-012418-6ralcn8p	587	15	of	of	IN
cord-012418-6ralcn8p	587	16	Interferon	Interferon	NNP
cord-012418-6ralcn8p	587	17	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	587	18	Factor	Factor	NNP
cord-012418-6ralcn8p	587	19	3	3	CD
cord-012418-6ralcn8p	587	20	to	to	IN
cord-012418-6ralcn8p	587	21	the	the	DT
cord-012418-6ralcn8p	587	22	Nucleus	Nucleus	NNP
cord-012418-6ralcn8p	587	23	Bromodomain	Bromodomain	NNP
cord-012418-6ralcn8p	587	24	protein	protein	NN
cord-012418-6ralcn8p	587	25	Brd3	Brd3	NNP
cord-012418-6ralcn8p	587	26	promotes	promote	VBZ
cord-012418-6ralcn8p	587	27	Ifnb1	ifnb1	JJ
cord-012418-6ralcn8p	587	28	transcription	transcription	NN
cord-012418-6ralcn8p	587	29	via	via	IN
cord-012418-6ralcn8p	587	30	enhancing	enhance	VBG
cord-012418-6ralcn8p	587	31	IRF3	IRF3	NNP
cord-012418-6ralcn8p	587	32	/	/	SYM
cord-012418-6ralcn8p	587	33	p300	p300	NNP
cord-012418-6ralcn8p	587	34	complex	complex	JJ
cord-012418-6ralcn8p	587	35	formation	formation	NN
cord-012418-6ralcn8p	587	36	and	and	CC
cord-012418-6ralcn8p	587	37	recruitment	recruitment	NN
cord-012418-6ralcn8p	587	38	to	to	IN
cord-012418-6ralcn8p	587	39	Ifnb1	ifnb1	JJ
cord-012418-6ralcn8p	587	40	promoter	promoter	NN
cord-012418-6ralcn8p	587	41	in	in	IN
cord-012418-6ralcn8p	587	42	macrophages	macrophage	NNS
cord-012418-6ralcn8p	588	1	OTUD1	otud1	NN
cord-012418-6ralcn8p	589	1	Negatively	negatively	RB
cord-012418-6ralcn8p	589	2	Regulates	regulate	VBZ
cord-012418-6ralcn8p	589	3	Type	type	NN
cord-012418-6ralcn8p	589	4	I	-PRON-	PRP
cord-012418-6ralcn8p	589	5	IFN	IFN	NNP
cord-012418-6ralcn8p	589	6	Induction	Induction	NNP
cord-012418-6ralcn8p	589	7	by	by	IN
cord-012418-6ralcn8p	589	8	Disrupting	disrupt	VBG
cord-012418-6ralcn8p	589	9	Noncanonical	Noncanonical	NNP
cord-012418-6ralcn8p	589	10	Ubiquitination	Ubiquitination	NNP
cord-012418-6ralcn8p	589	11	of	of	IN
cord-012418-6ralcn8p	589	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	590	1	The	the	DT
cord-012418-6ralcn8p	590	2	transcription	transcription	NN
cord-012418-6ralcn8p	590	3	factor	factor	NN
cord-012418-6ralcn8p	590	4	NFAT5	nfat5	XX
cord-012418-6ralcn8p	590	5	limits	limit	VBZ
cord-012418-6ralcn8p	590	6	infection	infection	NN
cord-012418-6ralcn8p	590	7	-	-	HYPH
cord-012418-6ralcn8p	590	8	induced	induce	VBN
cord-012418-6ralcn8p	590	9	type	type	NN
cord-012418-6ralcn8p	591	1	I	-PRON-	PRP
cord-012418-6ralcn8p	592	1	interferon	interferon	NNP
cord-012418-6ralcn8p	592	2	responses	response	NNS
cord-012418-6ralcn8p	593	1	The	the	DT
cord-012418-6ralcn8p	593	2	transcription	transcription	NN
cord-012418-6ralcn8p	593	3	factor	factor	NN
cord-012418-6ralcn8p	593	4	MafB	MafB	NNP
cord-012418-6ralcn8p	593	5	antagonizes	antagonize	VBZ
cord-012418-6ralcn8p	593	6	antiviral	antiviral	JJ
cord-012418-6ralcn8p	593	7	responses	response	NNS
cord-012418-6ralcn8p	593	8	by	by	IN
cord-012418-6ralcn8p	593	9	blocking	block	VBG
cord-012418-6ralcn8p	593	10	recruitment	recruitment	NN
cord-012418-6ralcn8p	593	11	of	of	IN
cord-012418-6ralcn8p	593	12	coactivators	coactivator	NNS
cord-012418-6ralcn8p	593	13	to	to	IN
cord-012418-6ralcn8p	593	14	the	the	DT
cord-012418-6ralcn8p	593	15	transcription	transcription	NN
cord-012418-6ralcn8p	593	16	factor	factor	NN
cord-012418-6ralcn8p	593	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	593	18	Involvement	Involvement	NNP
cord-012418-6ralcn8p	593	19	of	of	IN
cord-012418-6ralcn8p	593	20	the	the	DT
cord-012418-6ralcn8p	593	21	IkappaB	IkappaB	NNP
cord-012418-6ralcn8p	593	22	kinase	kinase	NN
cord-012418-6ralcn8p	593	23	(	(	-LRB-
cord-012418-6ralcn8p	593	24	IKK)-related	ikk)-relate	VBN
cord-012418-6ralcn8p	593	25	kinases	kinase	NNS
cord-012418-6ralcn8p	593	26	tank	tank	NN
cord-012418-6ralcn8p	593	27	-	-	HYPH
cord-012418-6ralcn8p	593	28	binding	bind	VBG
cord-012418-6ralcn8p	593	29	kinase	kinase	NN
cord-012418-6ralcn8p	593	30	1	1	CD
cord-012418-6ralcn8p	594	1	/IKKi	/IKKi	NFP
cord-012418-6ralcn8p	594	2	and	and	CC
cord-012418-6ralcn8p	594	3	cullin	cullin	NNP
cord-012418-6ralcn8p	594	4	-	-	HYPH
cord-012418-6ralcn8p	594	5	based	base	VBN
cord-012418-6ralcn8p	594	6	ubiquitin	ubiquitin	NN
cord-012418-6ralcn8p	594	7	ligases	ligase	NNS
cord-012418-6ralcn8p	594	8	in	in	IN
cord-012418-6ralcn8p	594	9	IFN	IFN	NNP
cord-012418-6ralcn8p	594	10	regulatory	regulatory	JJ
cord-012418-6ralcn8p	594	11	factor-3	factor-3	NNP
cord-012418-6ralcn8p	594	12	degradation	degradation	NN
cord-012418-6ralcn8p	594	13	Negative	negative	JJ
cord-012418-6ralcn8p	594	14	Regulation	regulation	NN
cord-012418-6ralcn8p	594	15	of	of	IN
cord-012418-6ralcn8p	594	16	Interferon	Interferon	NNP
cord-012418-6ralcn8p	594	17	-	-	HYPH
cord-012418-6ralcn8p	594	18	β	β	NNP
cord-012418-6ralcn8p	594	19	Gene	Gene	NNP
cord-012418-6ralcn8p	594	20	Expression	Expression	NNP
cord-012418-6ralcn8p	594	21	during	during	IN
cord-012418-6ralcn8p	594	22	Acute	acute	JJ
cord-012418-6ralcn8p	594	23	and	and	CC
cord-012418-6ralcn8p	594	24	Persistent	Persistent	NNP
cord-012418-6ralcn8p	594	25	Virus	Virus	NNP
cord-012418-6ralcn8p	594	26	Infections	Infections	NNPS
cord-012418-6ralcn8p	594	27	FoxO1	FoxO1	NNP
cord-012418-6ralcn8p	594	28	negatively	negatively	RB
cord-012418-6ralcn8p	594	29	regulates	regulate	VBZ
cord-012418-6ralcn8p	594	30	cellular	cellular	JJ
cord-012418-6ralcn8p	594	31	antiviral	antiviral	JJ
cord-012418-6ralcn8p	594	32	response	response	NN
cord-012418-6ralcn8p	594	33	by	by	IN
cord-012418-6ralcn8p	594	34	promoting	promote	VBG
cord-012418-6ralcn8p	594	35	degradation	degradation	NN
cord-012418-6ralcn8p	594	36	of	of	IN
cord-012418-6ralcn8p	594	37	IRF3	IRF3	NNP
cord-012418-6ralcn8p	595	1	TRIM26	TRIM26	NNP
cord-012418-6ralcn8p	595	2	negatively	negatively	RB
cord-012418-6ralcn8p	595	3	regulates	regulate	VBZ
cord-012418-6ralcn8p	595	4	interferon	interferon	NN
cord-012418-6ralcn8p	595	5	-	-	HYPH
cord-012418-6ralcn8p	595	6	β	β	NN
cord-012418-6ralcn8p	595	7	production	production	NN
cord-012418-6ralcn8p	595	8	and	and	CC
cord-012418-6ralcn8p	595	9	antiviral	antiviral	JJ
cord-012418-6ralcn8p	595	10	response	response	NN
cord-012418-6ralcn8p	595	11	through	through	IN
cord-012418-6ralcn8p	595	12	polyubiquitination	polyubiquitination	NN
cord-012418-6ralcn8p	595	13	and	and	CC
cord-012418-6ralcn8p	595	14	degradation	degradation	NN
cord-012418-6ralcn8p	595	15	of	of	IN
cord-012418-6ralcn8p	595	16	nuclear	nuclear	NN
cord-012418-6ralcn8p	596	1	IRF3	IRF3	NNP
cord-012418-6ralcn8p	596	2	Negative	negative	JJ
cord-012418-6ralcn8p	596	3	feedback	feedback	NN
cord-012418-6ralcn8p	596	4	regulation	regulation	NN
cord-012418-6ralcn8p	596	5	of	of	IN
cord-012418-6ralcn8p	596	6	cellular	cellular	JJ
cord-012418-6ralcn8p	596	7	antiviral	antiviral	JJ
cord-012418-6ralcn8p	596	8	signaling	signaling	NN
cord-012418-6ralcn8p	596	9	by	by	IN
cord-012418-6ralcn8p	596	10	RBCK1-mediated	rbck1-mediate	VBN
cord-012418-6ralcn8p	596	11	degradation	degradation	NN
cord-012418-6ralcn8p	596	12	of	of	IN
cord-012418-6ralcn8p	596	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	596	14	Caspase-8-mediated	caspase-8-mediate	VBN
cord-012418-6ralcn8p	596	15	cleavage	cleavage	NN
cord-012418-6ralcn8p	596	16	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	596	17	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	596	18	protein	protein	NN
cord-012418-6ralcn8p	596	19	by	by	IN
cord-012418-6ralcn8p	596	20	facilitating	facilitate	VBG
cord-012418-6ralcn8p	596	21	its	-PRON-	PRP$
cord-012418-6ralcn8p	596	22	proteasome	proteasome	NN
cord-012418-6ralcn8p	596	23	-	-	HYPH
cord-012418-6ralcn8p	596	24	mediated	mediate	VBN
cord-012418-6ralcn8p	596	25	degradation	degradation	NN
cord-012418-6ralcn8p	596	26	Krüppel	Krüppel	NNP
cord-012418-6ralcn8p	596	27	-	-	HYPH
cord-012418-6ralcn8p	596	28	like	like	JJ
cord-012418-6ralcn8p	596	29	factor	factor	NN
cord-012418-6ralcn8p	596	30	4	4	CD
cord-012418-6ralcn8p	596	31	negatively	negatively	RB
cord-012418-6ralcn8p	596	32	regulates	regulate	VBZ
cord-012418-6ralcn8p	597	1	cellular	cellular	JJ
cord-012418-6ralcn8p	597	2	antiviral	antiviral	JJ
cord-012418-6ralcn8p	597	3	immune	immune	JJ
cord-012418-6ralcn8p	597	4	response	response	NN
cord-012418-6ralcn8p	597	5	KAT8	KAT8	NNP
cord-012418-6ralcn8p	597	6	selectively	selectively	RB
cord-012418-6ralcn8p	597	7	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	597	8	antiviral	antiviral	JJ
cord-012418-6ralcn8p	597	9	immunity	immunity	NN
cord-012418-6ralcn8p	597	10	by	by	IN
cord-012418-6ralcn8p	597	11	acetylating	acetylate	VBG
cord-012418-6ralcn8p	597	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	598	1	A	a	DT
cord-012418-6ralcn8p	598	2	diverse	diverse	JJ
cord-012418-6ralcn8p	598	3	range	range	NN
cord-012418-6ralcn8p	598	4	of	of	IN
cord-012418-6ralcn8p	598	5	gene	gene	NN
cord-012418-6ralcn8p	598	6	products	product	NNS
cord-012418-6ralcn8p	598	7	are	be	VBP
cord-012418-6ralcn8p	598	8	effectors	effector	NNS
cord-012418-6ralcn8p	598	9	of	of	IN
cord-012418-6ralcn8p	598	10	the	the	DT
cord-012418-6ralcn8p	598	11	type	type	NN
cord-012418-6ralcn8p	599	1	I	-PRON-	PRP
cord-012418-6ralcn8p	599	2	interferon	interferon	VBP
cord-012418-6ralcn8p	599	3	antiviral	antiviral	JJ
cord-012418-6ralcn8p	599	4	response	response	NN
cord-012418-6ralcn8p	599	5	DDX56	DDX56	NNP
cord-012418-6ralcn8p	599	6	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	599	7	type	type	NN
cord-012418-6ralcn8p	599	8	I	-PRON-	PRP
cord-012418-6ralcn8p	599	9	interferon	interferon	RB
cord-012418-6ralcn8p	599	10	by	by	IN
cord-012418-6ralcn8p	599	11	disrupting	disrupt	VBG
cord-012418-6ralcn8p	599	12	assembly	assembly	NN
cord-012418-6ralcn8p	599	13	of	of	IN
cord-012418-6ralcn8p	599	14	IRF3-IPO5	IRF3-IPO5	NNP
cord-012418-6ralcn8p	599	15	to	to	TO
cord-012418-6ralcn8p	599	16	inhibit	inhibit	VB
cord-012418-6ralcn8p	599	17	IRF3	IRF3	NNP
cord-012418-6ralcn8p	599	18	nucleus	nucleus	NN
cord-012418-6ralcn8p	599	19	import	import	NN
cord-012418-6ralcn8p	599	20	LYAR	LYAR	NNP
cord-012418-6ralcn8p	600	1	Suppresses	suppress	VBZ
cord-012418-6ralcn8p	600	2	Beta	Beta	NNP
cord-012418-6ralcn8p	600	3	Interferon	Interferon	NNP
cord-012418-6ralcn8p	600	4	Induction	Induction	NNP
cord-012418-6ralcn8p	600	5	by	by	IN
cord-012418-6ralcn8p	600	6	Targeting	target	VBG
cord-012418-6ralcn8p	600	7	Phosphorylated	Phosphorylated	NNP
cord-012418-6ralcn8p	601	1	Interferon	Interferon	NNP
cord-012418-6ralcn8p	601	2	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	601	3	Factor	Factor	NNP
cord-012418-6ralcn8p	601	4	3	3	CD
cord-012418-6ralcn8p	601	5	Long	Long	NNP
cord-012418-6ralcn8p	601	6	Noncoding	Noncoding	NNP
cord-012418-6ralcn8p	601	7	RNA	RNA	NNP
cord-012418-6ralcn8p	601	8	Lnc	Lnc	NNP
cord-012418-6ralcn8p	601	9	-	-	HYPH
cord-012418-6ralcn8p	601	10	MxA	MxA	NNP
cord-012418-6ralcn8p	601	11	Inhibits	inhibit	VBZ
cord-012418-6ralcn8p	601	12	Beta	Beta	NNP
cord-012418-6ralcn8p	601	13	Interferon	Interferon	NNP
cord-012418-6ralcn8p	601	14	Transcription	Transcription	NNP
cord-012418-6ralcn8p	601	15	by	by	IN
cord-012418-6ralcn8p	601	16	Forming	form	VBG
cord-012418-6ralcn8p	601	17	RNA	RNA	NNP
cord-012418-6ralcn8p	601	18	-	-	HYPH
cord-012418-6ralcn8p	601	19	DNA	DNA	NNP
cord-012418-6ralcn8p	601	20	Triplexes	Triplexes	NNP
cord-012418-6ralcn8p	601	21	at	at	IN
cord-012418-6ralcn8p	601	22	Its	-PRON-	PRP$
cord-012418-6ralcn8p	601	23	Promoter	Promoter	NNP
cord-012418-6ralcn8p	601	24	PRDI	PRDI	NNP
cord-012418-6ralcn8p	601	25	-	-	HYPH
cord-012418-6ralcn8p	601	26	BF1	BF1	NNP
cord-012418-6ralcn8p	602	1	recruits	recruit	VBZ
cord-012418-6ralcn8p	602	2	the	the	DT
cord-012418-6ralcn8p	602	3	histone	histone	NN
cord-012418-6ralcn8p	602	4	H3	H3	NNP
cord-012418-6ralcn8p	603	1	methyltransferase	methyltransferase	NNP
cord-012418-6ralcn8p	603	2	G9a	G9a	NNP
cord-012418-6ralcn8p	603	3	in	in	IN
cord-012418-6ralcn8p	603	4	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	603	5	silencing	silencing	NN
cord-012418-6ralcn8p	603	6	Identification	identification	NN
cord-012418-6ralcn8p	603	7	and	and	CC
cord-012418-6ralcn8p	603	8	characterization	characterization	NN
cord-012418-6ralcn8p	603	9	of	of	IN
cord-012418-6ralcn8p	603	10	a	a	DT
cord-012418-6ralcn8p	603	11	novel	novel	JJ
cord-012418-6ralcn8p	603	12	repressor	repressor	NN
cord-012418-6ralcn8p	603	13	of	of	IN
cord-012418-6ralcn8p	603	14	beta	beta	NN
cord-012418-6ralcn8p	603	15	-	-	HYPH
cord-012418-6ralcn8p	603	16	interferon	interferon	NN
cord-012418-6ralcn8p	603	17	gene	gene	NN
cord-012418-6ralcn8p	603	18	expression	expression	NN
cord-012418-6ralcn8p	604	1	The	the	DT
cord-012418-6ralcn8p	604	2	EF	EF	NNP
cord-012418-6ralcn8p	604	3	-	-	HYPH
cord-012418-6ralcn8p	604	4	Hand	Hand	NNP
cord-012418-6ralcn8p	604	5	Protein	Protein	NNP
cord-012418-6ralcn8p	604	6	CALML6	CALML6	NNS
cord-012418-6ralcn8p	604	7	Suppresses	suppress	VBZ
cord-012418-6ralcn8p	604	8	Antiviral	antiviral	JJ
cord-012418-6ralcn8p	604	9	Innate	innate	JJ
cord-012418-6ralcn8p	604	10	Immunity	immunity	NN
cord-012418-6ralcn8p	604	11	by	by	IN
cord-012418-6ralcn8p	604	12	Impairing	impair	VBG
cord-012418-6ralcn8p	604	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	604	14	Dimerization	dimerization	NN
cord-012418-6ralcn8p	604	15	cFLIPL	cFLIPL	NNP
cord-012418-6ralcn8p	604	16	Interrupts	interrupt	VBZ
cord-012418-6ralcn8p	604	17	IRF3-CBP	IRF3-CBP	NNP
cord-012418-6ralcn8p	604	18	-	-	HYPH
cord-012418-6ralcn8p	604	19	DNA	dna	NN
cord-012418-6ralcn8p	604	20	Interactions	interaction	NNS
cord-012418-6ralcn8p	605	1	To	to	TO
cord-012418-6ralcn8p	605	2	Inhibit	inhibit	VB
cord-012418-6ralcn8p	605	3	IRF3-Driven	IRF3-Driven	NNP
cord-012418-6ralcn8p	605	4	Transcription	transcription	NN
cord-012418-6ralcn8p	606	1	Interferon	interferon	NN
cord-012418-6ralcn8p	606	2	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	3	factor	factor	NN
cord-012418-6ralcn8p	606	4	3-CL	3-cl	CD
cord-012418-6ralcn8p	606	5	,	,	,
cord-012418-6ralcn8p	606	6	an	an	DT
cord-012418-6ralcn8p	606	7	isoform	isoform	NN
cord-012418-6ralcn8p	606	8	of	of	IN
cord-012418-6ralcn8p	606	9	IRF3	IRF3	NNP
cord-012418-6ralcn8p	606	10	,	,	,
cord-012418-6ralcn8p	606	11	antagonizes	antagonize	VBZ
cord-012418-6ralcn8p	606	12	activity	activity	NN
cord-012418-6ralcn8p	606	13	of	of	IN
cord-012418-6ralcn8p	606	14	IRF3	IRF3	NNP
cord-012418-6ralcn8p	606	15	Functional	functional	JJ
cord-012418-6ralcn8p	606	16	characterization	characterization	NN
cord-012418-6ralcn8p	606	17	of	of	IN
cord-012418-6ralcn8p	606	18	interferon	interferon	NN
cord-012418-6ralcn8p	606	19	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	20	factor	factor	NN
cord-012418-6ralcn8p	606	21	3a	3a	NNP
cord-012418-6ralcn8p	606	22	(	(	-LRB-
cord-012418-6ralcn8p	606	23	IRF-3a	IRF-3a	NNP
cord-012418-6ralcn8p	606	24	)	)	-RRB-
cord-012418-6ralcn8p	606	25	,	,	,
cord-012418-6ralcn8p	606	26	an	an	DT
cord-012418-6ralcn8p	606	27	alternative	alternative	JJ
cord-012418-6ralcn8p	606	28	splice	splice	NN
cord-012418-6ralcn8p	606	29	isoform	isoform	NN
cord-012418-6ralcn8p	606	30	of	of	IN
cord-012418-6ralcn8p	606	31	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	606	32	Dual	dual	JJ
cord-012418-6ralcn8p	606	33	utilization	utilization	NN
cord-012418-6ralcn8p	606	34	of	of	IN
cord-012418-6ralcn8p	606	35	an	an	DT
cord-012418-6ralcn8p	606	36	acceptor	acceptor	NN
cord-012418-6ralcn8p	606	37	/	/	SYM
cord-012418-6ralcn8p	606	38	donor	donor	NN
cord-012418-6ralcn8p	606	39	splice	splice	NN
cord-012418-6ralcn8p	606	40	site	site	NN
cord-012418-6ralcn8p	606	41	governs	govern	VBZ
cord-012418-6ralcn8p	606	42	the	the	DT
cord-012418-6ralcn8p	606	43	alternative	alternative	JJ
cord-012418-6ralcn8p	606	44	splicing	splicing	NN
cord-012418-6ralcn8p	606	45	of	of	IN
cord-012418-6ralcn8p	606	46	the	the	DT
cord-012418-6ralcn8p	606	47	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	606	48	gene	gene	NN
cord-012418-6ralcn8p	606	49	Inhibition	inhibition	NN
cord-012418-6ralcn8p	606	50	of	of	IN
cord-012418-6ralcn8p	606	51	the	the	DT
cord-012418-6ralcn8p	606	52	IFN	IFN	NNP
cord-012418-6ralcn8p	606	53	-	-	HYPH
cord-012418-6ralcn8p	606	54	beta	beta	NN
cord-012418-6ralcn8p	606	55	response	response	NN
cord-012418-6ralcn8p	606	56	in	in	IN
cord-012418-6ralcn8p	606	57	hepatocellular	hepatocellular	JJ
cord-012418-6ralcn8p	606	58	carcinoma	carcinoma	NN
cord-012418-6ralcn8p	606	59	by	by	IN
cord-012418-6ralcn8p	606	60	alternative	alternative	JJ
cord-012418-6ralcn8p	606	61	spliced	splice	VBN
cord-012418-6ralcn8p	606	62	isoform	isoform	NN
cord-012418-6ralcn8p	606	63	of	of	IN
cord-012418-6ralcn8p	606	64	IFN	IFN	NNP
cord-012418-6ralcn8p	606	65	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	66	factor-3	factor-3	NNP
cord-012418-6ralcn8p	606	67	Characterization	characterization	NN
cord-012418-6ralcn8p	606	68	of	of	IN
cord-012418-6ralcn8p	606	69	a	a	DT
cord-012418-6ralcn8p	606	70	novel	novel	JJ
cord-012418-6ralcn8p	606	71	isoform	isoform	NN
cord-012418-6ralcn8p	606	72	of	of	IN
cord-012418-6ralcn8p	606	73	murine	murine	JJ
cord-012418-6ralcn8p	606	74	interferon	interferon	NN
cord-012418-6ralcn8p	606	75	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	76	factor	factor	NN
cord-012418-6ralcn8p	606	77	3	3	CD
cord-012418-6ralcn8p	606	78	Human	Human	NNP
cord-012418-6ralcn8p	606	79	papillomavirus	papillomavirus	NN
cord-012418-6ralcn8p	606	80	16	16	CD
cord-012418-6ralcn8p	606	81	E6	E6	NNP
cord-012418-6ralcn8p	606	82	oncoprotein	oncoprotein	NN
cord-012418-6ralcn8p	606	83	binds	bind	VBZ
cord-012418-6ralcn8p	606	84	to	to	IN
cord-012418-6ralcn8p	606	85	interferon	interferon	NN
cord-012418-6ralcn8p	606	86	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	87	factor-3	factor-3	NNP
cord-012418-6ralcn8p	606	88	and	and	CC
cord-012418-6ralcn8p	606	89	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	606	90	its	-PRON-	PRP$
cord-012418-6ralcn8p	606	91	transcriptional	transcriptional	JJ
cord-012418-6ralcn8p	606	92	activity	activity	NN
cord-012418-6ralcn8p	606	93	Primary	primary	JJ
cord-012418-6ralcn8p	606	94	activation	activation	NN
cord-012418-6ralcn8p	606	95	of	of	IN
cord-012418-6ralcn8p	606	96	interferon	interferon	NN
cord-012418-6ralcn8p	606	97	A	a	NN
cord-012418-6ralcn8p	606	98	and	and	CC
cord-012418-6ralcn8p	606	99	interferon	interferon	NN
cord-012418-6ralcn8p	606	100	B	b	NN
cord-012418-6ralcn8p	606	101	gene	gene	NN
cord-012418-6ralcn8p	606	102	transcription	transcription	NN
cord-012418-6ralcn8p	606	103	by	by	IN
cord-012418-6ralcn8p	606	104	interferon	interferon	NN
cord-012418-6ralcn8p	606	105	regulatory	regulatory	JJ
cord-012418-6ralcn8p	606	106	factor	factor	NN
cord-012418-6ralcn8p	607	1	3	3	LS
cord-012418-6ralcn8p	607	2	Recent	recent	JJ
cord-012418-6ralcn8p	607	3	advances	advance	NNS
cord-012418-6ralcn8p	607	4	in	in	IN
cord-012418-6ralcn8p	607	5	understanding	understand	VBG
cord-012418-6ralcn8p	607	6	viral	viral	JJ
cord-012418-6ralcn8p	607	7	evasion	evasion	NN
cord-012418-6ralcn8p	607	8	of	of	IN
cord-012418-6ralcn8p	607	9	type	type	NN
cord-012418-6ralcn8p	608	1	I	-PRON-	PRP
cord-012418-6ralcn8p	608	2	interferon	interferon	VBD
cord-012418-6ralcn8p	608	3	Cellular	cellular	JJ
cord-012418-6ralcn8p	608	4	sensing	sensing	NN
cord-012418-6ralcn8p	608	5	of	of	IN
cord-012418-6ralcn8p	608	6	viral	viral	JJ
cord-012418-6ralcn8p	608	7	DNA	dna	NN
cord-012418-6ralcn8p	608	8	and	and	CC
cord-012418-6ralcn8p	608	9	viral	viral	JJ
cord-012418-6ralcn8p	608	10	evasion	evasion	NN
cord-012418-6ralcn8p	608	11	mechanisms	mechanism	NNS
cord-012418-6ralcn8p	609	1	Early	early	RB
cord-012418-6ralcn8p	609	2	IFN	IFN	NNP
cord-012418-6ralcn8p	609	3	type	type	NN
cord-012418-6ralcn8p	609	4	I	-PRON-	PRP
cord-012418-6ralcn8p	609	5	response	response	NN
cord-012418-6ralcn8p	609	6	:	:	:
cord-012418-6ralcn8p	610	1	Learning	learn	VBG
cord-012418-6ralcn8p	610	2	from	from	IN
cord-012418-6ralcn8p	610	3	microbial	microbial	JJ
cord-012418-6ralcn8p	610	4	evasion	evasion	NN
cord-012418-6ralcn8p	610	5	strategies	strategy	NNS
cord-012418-6ralcn8p	610	6	Viral	Viral	NNP
cord-012418-6ralcn8p	610	7	Evasion	Evasion	NNP
cord-012418-6ralcn8p	610	8	Strategies	Strategies	NNPS
cord-012418-6ralcn8p	610	9	in	in	IN
cord-012418-6ralcn8p	610	10	Type	type	NN
cord-012418-6ralcn8p	611	1	I	-PRON-	PRP
cord-012418-6ralcn8p	611	2	IFN	IFN	NNP
cord-012418-6ralcn8p	611	3	Signaling	Signaling	NNP
cord-012418-6ralcn8p	611	4	-	-	HYPH
cord-012418-6ralcn8p	611	5	A	A	NNP
cord-012418-6ralcn8p	611	6	Summary	Summary	NNP
cord-012418-6ralcn8p	611	7	of	of	IN
cord-012418-6ralcn8p	611	8	Recent	recent	JJ
cord-012418-6ralcn8p	611	9	Developments	development	NNS
cord-012418-6ralcn8p	611	10	Viral	viral	JJ
cord-012418-6ralcn8p	611	11	dedication	dedication	NN
cord-012418-6ralcn8p	611	12	to	to	IN
cord-012418-6ralcn8p	611	13	vigorous	vigorous	JJ
cord-012418-6ralcn8p	611	14	destruction	destruction	NN
cord-012418-6ralcn8p	611	15	of	of	IN
cord-012418-6ralcn8p	611	16	interferon	interferon	NN
cord-012418-6ralcn8p	611	17	receptors	receptor	NNS
cord-012418-6ralcn8p	611	18	On	on	IN
cord-012418-6ralcn8p	611	19	taking	take	VBG
cord-012418-6ralcn8p	611	20	the	the	DT
cord-012418-6ralcn8p	611	21	STING	sting	NN
cord-012418-6ralcn8p	611	22	out	out	IN
cord-012418-6ralcn8p	611	23	of	of	IN
cord-012418-6ralcn8p	611	24	immune	immune	JJ
cord-012418-6ralcn8p	611	25	activation	activation	NN
cord-012418-6ralcn8p	612	1	Cytosolic	Cytosolic	NNP
cord-012418-6ralcn8p	612	2	DNA	dna	NN
cord-012418-6ralcn8p	612	3	-	-	HYPH
cord-012418-6ralcn8p	612	4	sensing	sense	VBG
cord-012418-6ralcn8p	612	5	immune	immune	JJ
cord-012418-6ralcn8p	612	6	response	response	NN
cord-012418-6ralcn8p	612	7	and	and	CC
cord-012418-6ralcn8p	612	8	viral	viral	JJ
cord-012418-6ralcn8p	612	9	infection	infection	NN
cord-012418-6ralcn8p	613	1	Intracellular	Intracellular	NNP
cord-012418-6ralcn8p	613	2	sensing	sensing	NN
cord-012418-6ralcn8p	613	3	of	of	IN
cord-012418-6ralcn8p	613	4	viral	viral	JJ
cord-012418-6ralcn8p	613	5	genomes	genome	NNS
cord-012418-6ralcn8p	613	6	and	and	CC
cord-012418-6ralcn8p	613	7	viral	viral	JJ
cord-012418-6ralcn8p	613	8	evasion	evasion	NN
cord-012418-6ralcn8p	613	9	Herpes	Herpes	NNP
cord-012418-6ralcn8p	613	10	Simplex	Simplex	NNP
cord-012418-6ralcn8p	613	11	Virus	Virus	NNP
cord-012418-6ralcn8p	613	12	Type	type	NN
cord-012418-6ralcn8p	613	13	2	2	CD
cord-012418-6ralcn8p	614	1	Immediate	Immediate	NNP
cord-012418-6ralcn8p	614	2	Early	Early	NNP
cord-012418-6ralcn8p	614	3	Protein	Protein	NNP
cord-012418-6ralcn8p	615	1	ICP27	ICP27	NNP
cord-012418-6ralcn8p	615	2	Inhibits	inhibit	VBZ
cord-012418-6ralcn8p	615	3	IFN	IFN	NNP
cord-012418-6ralcn8p	615	4	-	-	HYPH
cord-012418-6ralcn8p	615	5	β	β	NNP
cord-012418-6ralcn8p	615	6	Production	production	NN
cord-012418-6ralcn8p	615	7	in	in	IN
cord-012418-6ralcn8p	615	8	Mucosal	Mucosal	NNP
cord-012418-6ralcn8p	615	9	Epithelial	epithelial	JJ
cord-012418-6ralcn8p	615	10	Cells	cell	NNS
cord-012418-6ralcn8p	615	11	by	by	IN
cord-012418-6ralcn8p	615	12	Antagonizing	antagonize	VBG
cord-012418-6ralcn8p	615	13	IRF3	IRF3	NNP
cord-012418-6ralcn8p	616	1	Activation	activation	NN
cord-012418-6ralcn8p	617	1	Peste	Peste	NNP
cord-012418-6ralcn8p	617	2	des	des	NNP
cord-012418-6ralcn8p	617	3	Petits	Petits	NNP
cord-012418-6ralcn8p	618	1	Ruminants	ruminant	NNS
cord-012418-6ralcn8p	618	2	Virus	Virus	NNP
cord-012418-6ralcn8p	619	1	Nucleocapsid	Nucleocapsid	NNP
cord-012418-6ralcn8p	619	2	Protein	Protein	NNP
cord-012418-6ralcn8p	619	3	Inhibits	inhibit	VBZ
cord-012418-6ralcn8p	619	4	Beta	Beta	NNP
cord-012418-6ralcn8p	619	5	Interferon	Interferon	NNP
cord-012418-6ralcn8p	619	6	Production	production	NN
cord-012418-6ralcn8p	619	7	by	by	IN
cord-012418-6ralcn8p	619	8	Interacting	interact	VBG
cord-012418-6ralcn8p	619	9	with	with	IN
cord-012418-6ralcn8p	619	10	IRF3	IRF3	NNP
cord-012418-6ralcn8p	620	1	To	to	TO
cord-012418-6ralcn8p	620	2	Block	Block	NNP
cord-012418-6ralcn8p	620	3	Its	-PRON-	PRP$
cord-012418-6ralcn8p	620	4	Activation	Activation	NNP
cord-012418-6ralcn8p	620	5	Varicella	Varicella	NNP
cord-012418-6ralcn8p	620	6	-	-	HYPH
cord-012418-6ralcn8p	620	7	zoster	zoster	NN
cord-012418-6ralcn8p	620	8	virus	virus	NN
cord-012418-6ralcn8p	621	1	immediate	immediate	JJ
cord-012418-6ralcn8p	621	2	-	-	HYPH
cord-012418-6ralcn8p	621	3	early	early	JJ
cord-012418-6ralcn8p	621	4	protein	protein	NN
cord-012418-6ralcn8p	622	1	ORF61	ORF61	NNP
cord-012418-6ralcn8p	622	2	abrogates	abrogate	VBZ
cord-012418-6ralcn8p	622	3	the	the	DT
cord-012418-6ralcn8p	622	4	IRF3-mediated	irf3-mediate	VBN
cord-012418-6ralcn8p	622	5	innate	innate	JJ
cord-012418-6ralcn8p	622	6	immune	immune	JJ
cord-012418-6ralcn8p	622	7	response	response	NN
cord-012418-6ralcn8p	622	8	through	through	IN
cord-012418-6ralcn8p	622	9	degradation	degradation	NN
cord-012418-6ralcn8p	622	10	of	of	IN
cord-012418-6ralcn8p	622	11	activated	activate	VBN
cord-012418-6ralcn8p	622	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	622	13	Viral	viral	JJ
cord-012418-6ralcn8p	622	14	evasion	evasion	NN
cord-012418-6ralcn8p	622	15	and	and	CC
cord-012418-6ralcn8p	622	16	subversion	subversion	NN
cord-012418-6ralcn8p	622	17	of	of	IN
cord-012418-6ralcn8p	622	18	pattern	pattern	NN
cord-012418-6ralcn8p	622	19	-	-	HYPH
cord-012418-6ralcn8p	622	20	recognition	recognition	NN
cord-012418-6ralcn8p	622	21	receptor	receptor	NN
cord-012418-6ralcn8p	622	22	signalling	signal	VBG
cord-012418-6ralcn8p	622	23	Strategies	strategy	NNS
cord-012418-6ralcn8p	622	24	of	of	IN
cord-012418-6ralcn8p	622	25	highly	highly	RB
cord-012418-6ralcn8p	622	26	pathogenic	pathogenic	JJ
cord-012418-6ralcn8p	622	27	RNA	RNA	NNP
cord-012418-6ralcn8p	622	28	viruses	virus	NNS
cord-012418-6ralcn8p	622	29	to	to	TO
cord-012418-6ralcn8p	622	30	block	block	VB
cord-012418-6ralcn8p	622	31	dsRNA	dsrna	JJ
cord-012418-6ralcn8p	622	32	detection	detection	NN
cord-012418-6ralcn8p	622	33	by	by	IN
cord-012418-6ralcn8p	622	34	RIG	rig	NN
cord-012418-6ralcn8p	622	35	-	-	HYPH
cord-012418-6ralcn8p	622	36	I	i	NN
cord-012418-6ralcn8p	622	37	-	-	HYPH
cord-012418-6ralcn8p	622	38	like	like	JJ
cord-012418-6ralcn8p	622	39	receptors	receptor	NNS
cord-012418-6ralcn8p	622	40	:	:	:
cord-012418-6ralcn8p	623	1	Hide	hide	VB
cord-012418-6ralcn8p	623	2	,	,	,
cord-012418-6ralcn8p	623	3	mask	mask	NN
cord-012418-6ralcn8p	623	4	,	,	,
cord-012418-6ralcn8p	623	5	hit	hit	VBD
cord-012418-6ralcn8p	623	6	The	the	DT
cord-012418-6ralcn8p	623	7	interferon	interferon	NN
cord-012418-6ralcn8p	623	8	antiviral	antiviral	JJ
cord-012418-6ralcn8p	623	9	response	response	NN
cord-012418-6ralcn8p	623	10	:	:	:
cord-012418-6ralcn8p	624	1	From	from	IN
cord-012418-6ralcn8p	624	2	viral	viral	JJ
cord-012418-6ralcn8p	624	3	invasion	invasion	NN
cord-012418-6ralcn8p	624	4	to	to	TO
cord-012418-6ralcn8p	624	5	evasion	evasion	VB
cord-012418-6ralcn8p	624	6	Viral	viral	JJ
cord-012418-6ralcn8p	624	7	suppression	suppression	NN
cord-012418-6ralcn8p	624	8	of	of	IN
cord-012418-6ralcn8p	624	9	the	the	DT
cord-012418-6ralcn8p	624	10	interferon	interferon	NN
cord-012418-6ralcn8p	624	11	system	system	NN
cord-012418-6ralcn8p	624	12	Interferons	interferon	NNS
cord-012418-6ralcn8p	624	13	and	and	CC
cord-012418-6ralcn8p	624	14	viruses	virus	NNS
cord-012418-6ralcn8p	624	15	:	:	:
cord-012418-6ralcn8p	624	16	An	an	DT
cord-012418-6ralcn8p	624	17	interplay	interplay	NN
cord-012418-6ralcn8p	624	18	between	between	IN
cord-012418-6ralcn8p	624	19	induction	induction	NN
cord-012418-6ralcn8p	624	20	,	,	,
cord-012418-6ralcn8p	624	21	signalling	signal	VBG
cord-012418-6ralcn8p	624	22	,	,	,
cord-012418-6ralcn8p	624	23	antiviral	antiviral	JJ
cord-012418-6ralcn8p	624	24	responses	response	NNS
cord-012418-6ralcn8p	624	25	and	and	CC
cord-012418-6ralcn8p	624	26	virus	virus	NN
cord-012418-6ralcn8p	624	27	countermeasures	countermeasure	NNS
cord-012418-6ralcn8p	624	28	IFN	IFN	NNP
cord-012418-6ralcn8p	624	29	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	624	30	Factors	Factors	NNPS
cord-012418-6ralcn8p	624	31	and	and	CC
cord-012418-6ralcn8p	624	32	Antiviral	Antiviral	NNP
cord-012418-6ralcn8p	624	33	Innate	Innate	NNP
cord-012418-6ralcn8p	624	34	Immunity	immunity	NN
cord-012418-6ralcn8p	624	35	:	:	:
cord-012418-6ralcn8p	624	36	How	how	WRB
cord-012418-6ralcn8p	624	37	Viruses	virus	NNS
cord-012418-6ralcn8p	624	38	Can	Can	MD
cord-012418-6ralcn8p	624	39	Get	get	VB
cord-012418-6ralcn8p	624	40	Better	well	JJR
cord-012418-6ralcn8p	624	41	Ten	Ten	NNP
cord-012418-6ralcn8p	624	42	Strategies	strategy	NNS
cord-012418-6ralcn8p	624	43	of	of	IN
cord-012418-6ralcn8p	624	44	Interferon	Interferon	NNP
cord-012418-6ralcn8p	624	45	Evasion	Evasion	NNP
cord-012418-6ralcn8p	624	46	by	by	IN
cord-012418-6ralcn8p	624	47	Viruses	virus	NNS
cord-012418-6ralcn8p	625	1	The	the	DT
cord-012418-6ralcn8p	625	2	Molecular	Molecular	NNP
cord-012418-6ralcn8p	625	3	Basis	Basis	NNP
cord-012418-6ralcn8p	625	4	of	of	IN
cord-012418-6ralcn8p	625	5	Viral	Viral	NNP
cord-012418-6ralcn8p	625	6	Inhibition	Inhibition	NNP
cord-012418-6ralcn8p	625	7	of	of	IN
cord-012418-6ralcn8p	625	8	IRF	IRF	NNP
cord-012418-6ralcn8p	625	9	-	-	:
cord-012418-6ralcn8p	625	10	and	and	CC
cord-012418-6ralcn8p	625	11	STAT	stat	NN
cord-012418-6ralcn8p	625	12	-	-	HYPH
cord-012418-6ralcn8p	625	13	Dependent	dependent	JJ
cord-012418-6ralcn8p	625	14	Immune	Immune	NNP
cord-012418-6ralcn8p	625	15	Responses	response	NNS
cord-012418-6ralcn8p	625	16	Functional	functional	JJ
cord-012418-6ralcn8p	625	17	comparison	comparison	NN
cord-012418-6ralcn8p	625	18	of	of	IN
cord-012418-6ralcn8p	625	19	the	the	DT
cord-012418-6ralcn8p	625	20	two	two	CD
cord-012418-6ralcn8p	625	21	gene	gene	NN
cord-012418-6ralcn8p	625	22	products	product	NNS
cord-012418-6ralcn8p	625	23	of	of	IN
cord-012418-6ralcn8p	625	24	Thogoto	Thogoto	NNP
cord-012418-6ralcn8p	625	25	virus	virus	NN
cord-012418-6ralcn8p	625	26	segment	segment	NN
cord-012418-6ralcn8p	626	1	6	6	CD
cord-012418-6ralcn8p	626	2	Thogoto	Thogoto	NNP
cord-012418-6ralcn8p	626	3	virus	virus	NN
cord-012418-6ralcn8p	626	4	ML	ml	NN
cord-012418-6ralcn8p	626	5	protein	protein	NN
cord-012418-6ralcn8p	626	6	suppresses	suppress	VBZ
cord-012418-6ralcn8p	626	7	IRF3	IRF3	NNP
cord-012418-6ralcn8p	626	8	function	function	NN
cord-012418-6ralcn8p	627	1	The	the	DT
cord-012418-6ralcn8p	627	2	interferon	interferon	NN
cord-012418-6ralcn8p	627	3	antagonist	antagonist	NN
cord-012418-6ralcn8p	627	4	ML	ML	NNP
cord-012418-6ralcn8p	627	5	protein	protein	NN
cord-012418-6ralcn8p	627	6	of	of	IN
cord-012418-6ralcn8p	627	7	thogoto	thogoto	NNP
cord-012418-6ralcn8p	627	8	virus	virus	NN
cord-012418-6ralcn8p	627	9	targets	target	VBZ
cord-012418-6ralcn8p	627	10	general	general	JJ
cord-012418-6ralcn8p	627	11	transcription	transcription	NN
cord-012418-6ralcn8p	627	12	factor	factor	NN
cord-012418-6ralcn8p	628	1	IIB	IIB	NNP
cord-012418-6ralcn8p	628	2	Viral	viral	JJ
cord-012418-6ralcn8p	628	3	targeting	target	VBG
cord-012418-6ralcn8p	628	4	of	of	IN
cord-012418-6ralcn8p	628	5	TFIIB	TFIIB	NNP
cord-012418-6ralcn8p	628	6	impairs	impair	VBZ
cord-012418-6ralcn8p	629	1	de	de	NNP
cord-012418-6ralcn8p	629	2	novo	novo	NNP
cord-012418-6ralcn8p	629	3	polymerase	polymerase	NNP
cord-012418-6ralcn8p	629	4	II	II	NNP
cord-012418-6ralcn8p	629	5	recruitment	recruitment	NN
cord-012418-6ralcn8p	629	6	and	and	CC
cord-012418-6ralcn8p	629	7	affects	affect	VBZ
cord-012418-6ralcn8p	629	8	antiviral	antiviral	JJ
cord-012418-6ralcn8p	629	9	Immunity	Immunity	NNP
cord-012418-6ralcn8p	629	10	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-012418-6ralcn8p	629	11	traffic	traffic	NN
cord-012418-6ralcn8p	629	12	disorder	disorder	NN
cord-012418-6ralcn8p	629	13	induced	induce	VBN
cord-012418-6ralcn8p	629	14	by	by	IN
cord-012418-6ralcn8p	629	15	cardioviruses	cardioviruses	NNP
cord-012418-6ralcn8p	630	1	The	the	DT
cord-012418-6ralcn8p	630	2	mengovirus	mengovirus	JJ
cord-012418-6ralcn8p	630	3	leader	leader	NN
cord-012418-6ralcn8p	630	4	protein	protein	NN
cord-012418-6ralcn8p	630	5	blocks	block	NNS
cord-012418-6ralcn8p	631	1	interferon	interferon	NN
cord-012418-6ralcn8p	631	2	-	-	HYPH
cord-012418-6ralcn8p	631	3	alpha	alpha	NN
cord-012418-6ralcn8p	631	4	/	/	SYM
cord-012418-6ralcn8p	631	5	beta	beta	NN
cord-012418-6ralcn8p	631	6	gene	gene	NN
cord-012418-6ralcn8p	631	7	transcription	transcription	NN
cord-012418-6ralcn8p	631	8	and	and	CC
cord-012418-6ralcn8p	631	9	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	631	10	activation	activation	NN
cord-012418-6ralcn8p	631	11	of	of	IN
cord-012418-6ralcn8p	631	12	interferon	interferon	NN
cord-012418-6ralcn8p	631	13	regulatory	regulatory	JJ
cord-012418-6ralcn8p	631	14	factor	factor	NN
cord-012418-6ralcn8p	631	15	3	3	CD
cord-012418-6ralcn8p	632	1	The	the	DT
cord-012418-6ralcn8p	632	2	leader	leader	NN
cord-012418-6ralcn8p	632	3	protein	protein	NN
cord-012418-6ralcn8p	632	4	of	of	IN
cord-012418-6ralcn8p	632	5	Theiler	Theiler	NNP
cord-012418-6ralcn8p	632	6	's	's	POS
cord-012418-6ralcn8p	632	7	virus	virus	NN
cord-012418-6ralcn8p	632	8	interferes	interfere	VBZ
cord-012418-6ralcn8p	632	9	with	with	IN
cord-012418-6ralcn8p	632	10	nucleocytoplasmic	nucleocytoplasmic	JJ
cord-012418-6ralcn8p	632	11	trafficking	trafficking	NN
cord-012418-6ralcn8p	632	12	of	of	IN
cord-012418-6ralcn8p	632	13	cellular	cellular	JJ
cord-012418-6ralcn8p	632	14	proteins	protein	NNS
cord-012418-6ralcn8p	632	15	Inhibition	Inhibition	NNP
cord-012418-6ralcn8p	632	16	of	of	IN
cord-012418-6ralcn8p	632	17	mRNA	mRNA	NNP
cord-012418-6ralcn8p	632	18	export	export	NN
cord-012418-6ralcn8p	632	19	and	and	CC
cord-012418-6ralcn8p	632	20	dimerization	dimerization	NN
cord-012418-6ralcn8p	632	21	of	of	IN
cord-012418-6ralcn8p	632	22	interferon	interferon	NN
cord-012418-6ralcn8p	632	23	regulatory	regulatory	JJ
cord-012418-6ralcn8p	632	24	factor	factor	NN
cord-012418-6ralcn8p	632	25	3	3	CD
cord-012418-6ralcn8p	632	26	by	by	IN
cord-012418-6ralcn8p	632	27	Theiler	Theiler	NNP
cord-012418-6ralcn8p	632	28	's	's	POS
cord-012418-6ralcn8p	632	29	virus	virus	NN
cord-012418-6ralcn8p	632	30	leader	leader	NN
cord-012418-6ralcn8p	632	31	protein	protein	NN
cord-012418-6ralcn8p	632	32	Herpes	Herpes	NNP
cord-012418-6ralcn8p	632	33	simplex	simplex	NN
cord-012418-6ralcn8p	632	34	virus	virus	NN
cord-012418-6ralcn8p	632	35	1	1	CD
cord-012418-6ralcn8p	632	36	serine	serine	NN
cord-012418-6ralcn8p	632	37	/	/	SYM
cord-012418-6ralcn8p	632	38	threonine	threonine	NN
cord-012418-6ralcn8p	632	39	kinase	kinase	VBZ
cord-012418-6ralcn8p	632	40	US3	US3	NNP
cord-012418-6ralcn8p	632	41	hyperphosphorylates	hyperphosphorylates	NNP
cord-012418-6ralcn8p	632	42	IRF3	IRF3	NNP
cord-012418-6ralcn8p	632	43	and	and	CC
cord-012418-6ralcn8p	632	44	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	632	45	beta	beta	NN
cord-012418-6ralcn8p	632	46	interferon	interferon	NN
cord-012418-6ralcn8p	632	47	production	production	NN
cord-012418-6ralcn8p	632	48	Recovery	Recovery	NNP
cord-012418-6ralcn8p	632	49	of	of	IN
cord-012418-6ralcn8p	632	50	paramyxovirus	paramyxovirus	JJ
cord-012418-6ralcn8p	632	51	simian	simian	JJ
cord-012418-6ralcn8p	632	52	virus	virus	NN
cord-012418-6ralcn8p	632	53	5	5	CD
cord-012418-6ralcn8p	632	54	with	with	IN
cord-012418-6ralcn8p	632	55	a	a	DT
cord-012418-6ralcn8p	632	56	V	v	NN
cord-012418-6ralcn8p	632	57	protein	protein	NN
cord-012418-6ralcn8p	632	58	lacking	lack	VBG
cord-012418-6ralcn8p	632	59	the	the	DT
cord-012418-6ralcn8p	632	60	conserved	conserve	VBN
cord-012418-6ralcn8p	632	61	cysteine	cysteine	NN
cord-012418-6ralcn8p	632	62	-	-	HYPH
cord-012418-6ralcn8p	632	63	rich	rich	JJ
cord-012418-6ralcn8p	632	64	domain	domain	NN
cord-012418-6ralcn8p	632	65	:	:	:
cord-012418-6ralcn8p	633	1	The	the	DT
cord-012418-6ralcn8p	633	2	multifunctional	multifunctional	JJ
cord-012418-6ralcn8p	633	3	V	v	NN
cord-012418-6ralcn8p	633	4	protein	protein	NN
cord-012418-6ralcn8p	633	5	blocks	block	NNS
cord-012418-6ralcn8p	634	1	both	both	DT
cord-012418-6ralcn8p	634	2	interferon	interferon	NN
cord-012418-6ralcn8p	634	3	-	-	HYPH
cord-012418-6ralcn8p	634	4	beta	beta	NN
cord-012418-6ralcn8p	634	5	induction	induction	NN
cord-012418-6ralcn8p	634	6	and	and	CC
cord-012418-6ralcn8p	634	7	interferon	interferon	NN
cord-012418-6ralcn8p	634	8	signaling	signal	VBG
cord-012418-6ralcn8p	634	9	The	the	DT
cord-012418-6ralcn8p	634	10	N	N	NNP
cord-012418-6ralcn8p	634	11	-	-	HYPH
cord-012418-6ralcn8p	634	12	and	and	CC
cord-012418-6ralcn8p	634	13	C	c	NN
cord-012418-6ralcn8p	634	14	-	-	HYPH
cord-012418-6ralcn8p	634	15	terminal	terminal	NN
cord-012418-6ralcn8p	634	16	domains	domain	NNS
cord-012418-6ralcn8p	634	17	of	of	IN
cord-012418-6ralcn8p	634	18	the	the	DT
cord-012418-6ralcn8p	634	19	NS1	ns1	NN
cord-012418-6ralcn8p	634	20	protein	protein	NN
cord-012418-6ralcn8p	634	21	of	of	IN
cord-012418-6ralcn8p	634	22	influenza	influenza	NN
cord-012418-6ralcn8p	634	23	B	B	NNP
cord-012418-6ralcn8p	634	24	virus	virus	NN
cord-012418-6ralcn8p	634	25	can	can	MD
cord-012418-6ralcn8p	634	26	independently	independently	RB
cord-012418-6ralcn8p	634	27	inhibit	inhibit	VB
cord-012418-6ralcn8p	634	28	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	634	29	and	and	CC
cord-012418-6ralcn8p	634	30	beta	beta	NN
cord-012418-6ralcn8p	634	31	interferon	interferon	NN
cord-012418-6ralcn8p	634	32	promoter	promoter	NN
cord-012418-6ralcn8p	634	33	activation	activation	NN
cord-012418-6ralcn8p	634	34	Cellular	cellular	JJ
cord-012418-6ralcn8p	634	35	localization	localization	NN
cord-012418-6ralcn8p	634	36	of	of	IN
cord-012418-6ralcn8p	634	37	the	the	DT
cord-012418-6ralcn8p	634	38	herpes	herpes	NNP
cord-012418-6ralcn8p	634	39	simplex	simplex	NNP
cord-012418-6ralcn8p	634	40	virus	virus	NN
cord-012418-6ralcn8p	634	41	ICP0	ICP0	NNP
cord-012418-6ralcn8p	634	42	protein	protein	NN
cord-012418-6ralcn8p	634	43	dictates	dictate	VBZ
cord-012418-6ralcn8p	634	44	its	-PRON-	PRP$
cord-012418-6ralcn8p	634	45	ability	ability	NN
cord-012418-6ralcn8p	634	46	to	to	TO
cord-012418-6ralcn8p	634	47	block	block	VB
cord-012418-6ralcn8p	634	48	IRF3-mediated	irf3-mediate	VBN
cord-012418-6ralcn8p	634	49	innate	innate	JJ
cord-012418-6ralcn8p	634	50	immune	immune	JJ
cord-012418-6ralcn8p	634	51	responses	response	NNS
cord-012418-6ralcn8p	634	52	Analysis	Analysis	NNP
cord-012418-6ralcn8p	634	53	of	of	IN
cord-012418-6ralcn8p	634	54	interaction	interaction	NN
cord-012418-6ralcn8p	634	55	of	of	IN
cord-012418-6ralcn8p	634	56	Sendai	Sendai	NNP
cord-012418-6ralcn8p	634	57	virus	virus	NN
cord-012418-6ralcn8p	634	58	V	v	NN
cord-012418-6ralcn8p	634	59	protein	protein	NN
cord-012418-6ralcn8p	634	60	and	and	CC
cord-012418-6ralcn8p	634	61	melanoma	melanoma	NN
cord-012418-6ralcn8p	634	62	differentiation	differentiation	NN
cord-012418-6ralcn8p	634	63	-	-	HYPH
cord-012418-6ralcn8p	634	64	associated	associate	VBN
cord-012418-6ralcn8p	634	65	gene	gene	NN
cord-012418-6ralcn8p	634	66	5	5	CD
cord-012418-6ralcn8p	634	67	Cell	cell	NN
cord-012418-6ralcn8p	634	68	type	type	NN
cord-012418-6ralcn8p	634	69	-	-	HYPH
cord-012418-6ralcn8p	634	70	specific	specific	JJ
cord-012418-6ralcn8p	634	71	involvement	involvement	NN
cord-012418-6ralcn8p	634	72	of	of	IN
cord-012418-6ralcn8p	634	73	RIG	rig	NN
cord-012418-6ralcn8p	634	74	-	-	:
cord-012418-6ralcn8p	634	75	I	-PRON-	PRP
cord-012418-6ralcn8p	634	76	in	in	IN
cord-012418-6ralcn8p	634	77	antiviral	antiviral	JJ
cord-012418-6ralcn8p	634	78	response	response	NN
cord-012418-6ralcn8p	634	79	Activation	Activation	NNP
cord-012418-6ralcn8p	634	80	of	of	IN
cord-012418-6ralcn8p	634	81	innate	innate	JJ
cord-012418-6ralcn8p	634	82	defense	defense	NN
cord-012418-6ralcn8p	634	83	against	against	IN
cord-012418-6ralcn8p	634	84	a	a	DT
cord-012418-6ralcn8p	634	85	paramyxovirus	paramyxovirus	NN
cord-012418-6ralcn8p	634	86	is	be	VBZ
cord-012418-6ralcn8p	634	87	mediated	mediate	VBN
cord-012418-6ralcn8p	634	88	by	by	IN
cord-012418-6ralcn8p	634	89	RIG	rig	NN
cord-012418-6ralcn8p	634	90	-	-	:
cord-012418-6ralcn8p	634	91	I	I	NNP
cord-012418-6ralcn8p	634	92	and	and	CC
cord-012418-6ralcn8p	634	93	TLR7	TLR7	NNP
cord-012418-6ralcn8p	634	94	and	and	CC
cord-012418-6ralcn8p	634	95	TLR8	TLR8	NNP
cord-012418-6ralcn8p	634	96	in	in	IN
cord-012418-6ralcn8p	634	97	a	a	DT
cord-012418-6ralcn8p	634	98	cell	cell	NN
cord-012418-6ralcn8p	634	99	-	-	HYPH
cord-012418-6ralcn8p	634	100	type	type	NN
cord-012418-6ralcn8p	634	101	-	-	HYPH
cord-012418-6ralcn8p	634	102	specific	specific	JJ
cord-012418-6ralcn8p	634	103	manner	manner	NN
cord-012418-6ralcn8p	634	104	Differential	differential	JJ
cord-012418-6ralcn8p	634	105	roles	role	NNS
cord-012418-6ralcn8p	634	106	of	of	IN
cord-012418-6ralcn8p	634	107	MDA5	MDA5	NNP
cord-012418-6ralcn8p	634	108	and	and	CC
cord-012418-6ralcn8p	634	109	RIG	rig	NN
cord-012418-6ralcn8p	634	110	-	-	:
cord-012418-6ralcn8p	634	111	I	-PRON-	PRP
cord-012418-6ralcn8p	634	112	helicases	helicase	NNS
cord-012418-6ralcn8p	634	113	in	in	IN
cord-012418-6ralcn8p	634	114	the	the	DT
cord-012418-6ralcn8p	634	115	recognition	recognition	NN
cord-012418-6ralcn8p	634	116	of	of	IN
cord-012418-6ralcn8p	634	117	RNA	RNA	NNP
cord-012418-6ralcn8p	634	118	Viruses	Viruses	NNPS
cord-012418-6ralcn8p	634	119	Inhibition	Inhibition	NNP
cord-012418-6ralcn8p	634	120	of	of	IN
cord-012418-6ralcn8p	634	121	Interferon	Interferon	NNP
cord-012418-6ralcn8p	634	122	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	634	123	Factor	Factor	NNP
cord-012418-6ralcn8p	634	124	3	3	CD
cord-012418-6ralcn8p	634	125	Activation	Activation	NNP
cord-012418-6ralcn8p	634	126	by	by	IN
cord-012418-6ralcn8p	634	127	Paramyxovirus	Paramyxovirus	NNP
cord-012418-6ralcn8p	634	128	V	V	NNP
cord-012418-6ralcn8p	634	129	Protein	Protein	NNP
cord-012418-6ralcn8p	635	1	Japanese	japanese	JJ
cord-012418-6ralcn8p	635	2	Encephalitis	Encephalitis	NNP
cord-012418-6ralcn8p	635	3	Virus	virus	NN
cord-012418-6ralcn8p	635	4	NS5	NS5	NNP
cord-012418-6ralcn8p	635	5	Inhibits	inhibit	VBZ
cord-012418-6ralcn8p	635	6	Type	type	NN
cord-012418-6ralcn8p	636	1	I	-PRON-	PRP
cord-012418-6ralcn8p	637	1	Interferon	Interferon	NNP
cord-012418-6ralcn8p	637	2	(	(	-LRB-
cord-012418-6ralcn8p	637	3	IFN	IFN	NNP
cord-012418-6ralcn8p	637	4	)	)	-RRB-
cord-012418-6ralcn8p	637	5	Production	production	NN
cord-012418-6ralcn8p	637	6	by	by	IN
cord-012418-6ralcn8p	637	7	Blocking	block	VBG
cord-012418-6ralcn8p	637	8	the	the	DT
cord-012418-6ralcn8p	637	9	Nuclear	Nuclear	NNP
cord-012418-6ralcn8p	637	10	Translocation	Translocation	NNP
cord-012418-6ralcn8p	637	11	of	of	IN
cord-012418-6ralcn8p	637	12	IFN	IFN	NNP
cord-012418-6ralcn8p	637	13	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	637	14	Factor	Factor	NNP
cord-012418-6ralcn8p	637	15	3	3	CD
cord-012418-6ralcn8p	637	16	and	and	CC
cord-012418-6ralcn8p	637	17	NF	NF	NNP
cord-012418-6ralcn8p	638	1	-κB	-κB	:
cord-012418-6ralcn8p	638	2	Importin	Importin	NNP
cord-012418-6ralcn8p	638	3	beta1	beta1	NN
cord-012418-6ralcn8p	638	4	targeting	target	VBG
cord-012418-6ralcn8p	638	5	by	by	IN
cord-012418-6ralcn8p	638	6	hepatitis	hepatitis	NN
cord-012418-6ralcn8p	638	7	C	C	NNP
cord-012418-6ralcn8p	638	8	virus	virus	NN
cord-012418-6ralcn8p	638	9	NS3/4A	NS3/4A	NNP
cord-012418-6ralcn8p	638	10	protein	protein	NN
cord-012418-6ralcn8p	638	11	restricts	restrict	VBZ
cord-012418-6ralcn8p	638	12	IRF3	IRF3	NNP
cord-012418-6ralcn8p	638	13	and	and	CC
cord-012418-6ralcn8p	638	14	NF	NF	NNP
cord-012418-6ralcn8p	638	15	-	-	HYPH
cord-012418-6ralcn8p	638	16	kappaB	kappaB	NNP
cord-012418-6ralcn8p	638	17	signaling	signaling	NN
cord-012418-6ralcn8p	638	18	of	of	IN
cord-012418-6ralcn8p	638	19	IFNB1	ifnb1	DT
cord-012418-6ralcn8p	638	20	antiviral	antiviral	JJ
cord-012418-6ralcn8p	638	21	response	response	NN
cord-012418-6ralcn8p	638	22	A	a	DT
cord-012418-6ralcn8p	638	23	novel	novel	NN
cord-012418-6ralcn8p	638	24	mechanism	mechanism	NN
cord-012418-6ralcn8p	638	25	for	for	IN
cord-012418-6ralcn8p	638	26	the	the	DT
cord-012418-6ralcn8p	638	27	inhibition	inhibition	NN
cord-012418-6ralcn8p	638	28	of	of	IN
cord-012418-6ralcn8p	638	29	interferon	interferon	NN
cord-012418-6ralcn8p	638	30	regulatory	regulatory	JJ
cord-012418-6ralcn8p	638	31	factor-3-dependent	factor-3-dependent	JJ
cord-012418-6ralcn8p	638	32	gene	gene	NN
cord-012418-6ralcn8p	638	33	expression	expression	NN
cord-012418-6ralcn8p	638	34	by	by	IN
cord-012418-6ralcn8p	638	35	human	human	JJ
cord-012418-6ralcn8p	638	36	respiratory	respiratory	JJ
cord-012418-6ralcn8p	638	37	syncytial	syncytial	JJ
cord-012418-6ralcn8p	638	38	virus	virus	NN
cord-012418-6ralcn8p	638	39	NS1	ns1	CD
cord-012418-6ralcn8p	638	40	protein	protein	NN
cord-012418-6ralcn8p	639	1	The	the	DT
cord-012418-6ralcn8p	639	2	E6	E6	NNP
cord-012418-6ralcn8p	639	3	protein	protein	NN
cord-012418-6ralcn8p	639	4	of	of	IN
cord-012418-6ralcn8p	639	5	human	human	JJ
cord-012418-6ralcn8p	639	6	papillomavirus	papillomavirus	NN
cord-012418-6ralcn8p	639	7	type	type	NN
cord-012418-6ralcn8p	639	8	16	16	CD
cord-012418-6ralcn8p	639	9	binds	bind	VBZ
cord-012418-6ralcn8p	639	10	to	to	IN
cord-012418-6ralcn8p	639	11	and	and	CC
cord-012418-6ralcn8p	639	12	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	639	13	co	co	JJ
cord-012418-6ralcn8p	639	14	-	-	NN
cord-012418-6ralcn8p	639	15	activation	activation	NN
cord-012418-6ralcn8p	639	16	by	by	IN
cord-012418-6ralcn8p	639	17	CBP	CBP	NNP
cord-012418-6ralcn8p	639	18	and	and	CC
cord-012418-6ralcn8p	639	19	p300	p300	NN
cord-012418-6ralcn8p	639	20	Herpes	Herpes	NNP
cord-012418-6ralcn8p	639	21	Simplex	Simplex	NNP
cord-012418-6ralcn8p	639	22	Virus	Virus	NNP
cord-012418-6ralcn8p	640	1	1-Encoded	1-Encoded	NNP
cord-012418-6ralcn8p	640	2	Tegument	Tegument	NNP
cord-012418-6ralcn8p	640	3	Protein	Protein	NNP
cord-012418-6ralcn8p	641	1	VP16	VP16	NNP
cord-012418-6ralcn8p	641	2	Abrogates	abrogate	VBZ
cord-012418-6ralcn8p	641	3	the	the	DT
cord-012418-6ralcn8p	641	4	Production	production	NN
cord-012418-6ralcn8p	641	5	of	of	IN
cord-012418-6ralcn8p	641	6	Beta	Beta	NNP
cord-012418-6ralcn8p	641	7	Interferon	Interferon	NNP
cord-012418-6ralcn8p	641	8	(	(	-LRB-
cord-012418-6ralcn8p	641	9	IFN	IFN	NNP
cord-012418-6ralcn8p	641	10	)	)	-RRB-
cord-012418-6ralcn8p	641	11	by	by	IN
cord-012418-6ralcn8p	641	12	Inhibiting	inhibit	VBG
cord-012418-6ralcn8p	641	13	NF	NF	NNP
cord-012418-6ralcn8p	641	14	-	-	HYPH
cord-012418-6ralcn8p	641	15	κB	κb	CD
cord-012418-6ralcn8p	641	16	Activation	Activation	NNP
cord-012418-6ralcn8p	641	17	and	and	CC
cord-012418-6ralcn8p	641	18	Blocking	Blocking	NNP
cord-012418-6ralcn8p	641	19	IFN	IFN	NNP
cord-012418-6ralcn8p	641	20	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	641	21	Factor	Factor	NNP
cord-012418-6ralcn8p	641	22	3	3	CD
cord-012418-6ralcn8p	641	23	To	to	TO
cord-012418-6ralcn8p	641	24	Recruit	recruit	VB
cord-012418-6ralcn8p	642	1	Its	-PRON-	PRP$
cord-012418-6ralcn8p	642	2	Coactivator	Coactivator	NNP
cord-012418-6ralcn8p	642	3	CBP	CBP	NNP
cord-012418-6ralcn8p	642	4	Conserved	conserve	VBN
cord-012418-6ralcn8p	642	5	Herpesviral	Herpesviral	NNP
cord-012418-6ralcn8p	642	6	Kinase	Kinase	NNP
cord-012418-6ralcn8p	642	7	Promotes	promote	VBZ
cord-012418-6ralcn8p	642	8	Viral	viral	JJ
cord-012418-6ralcn8p	642	9	Persistence	persistence	NN
cord-012418-6ralcn8p	642	10	by	by	IN
cord-012418-6ralcn8p	642	11	Inhibiting	inhibit	VBG
cord-012418-6ralcn8p	642	12	the	the	DT
cord-012418-6ralcn8p	642	13	IRF-3-Mediated	IRF-3-Mediated	NNP
cord-012418-6ralcn8p	642	14	Type	Type	NNP
cord-012418-6ralcn8p	642	15	I	-PRON-	PRP
cord-012418-6ralcn8p	643	1	Interferon	interferon	NN
cord-012418-6ralcn8p	643	2	Response	response	NN
cord-012418-6ralcn8p	643	3	Beyond	beyond	IN
cord-012418-6ralcn8p	643	4	Viral	Viral	NNP
cord-012418-6ralcn8p	643	5	Interferon	Interferon	NNP
cord-012418-6ralcn8p	643	6	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	643	7	Factors	Factors	NNPS
cord-012418-6ralcn8p	643	8	:	:	:
cord-012418-6ralcn8p	644	1	Immune	immune	JJ
cord-012418-6ralcn8p	644	2	Evasion	evasion	NN
cord-012418-6ralcn8p	644	3	Strategies	Strategies	NNPS
cord-012418-6ralcn8p	644	4	Functional	functional	JJ
cord-012418-6ralcn8p	644	5	analysis	analysis	NN
cord-012418-6ralcn8p	644	6	of	of	IN
cord-012418-6ralcn8p	644	7	human	human	JJ
cord-012418-6ralcn8p	644	8	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	644	9	8-encoded	8-encoded	CD
cord-012418-6ralcn8p	644	10	viral	viral	JJ
cord-012418-6ralcn8p	644	11	interferon	interferon	NN
cord-012418-6ralcn8p	644	12	regulatory	regulatory	JJ
cord-012418-6ralcn8p	644	13	factor	factor	NN
cord-012418-6ralcn8p	644	14	1	1	CD
cord-012418-6ralcn8p	644	15	and	and	CC
cord-012418-6ralcn8p	644	16	its	-PRON-	PRP$
cord-012418-6ralcn8p	644	17	association	association	NN
cord-012418-6ralcn8p	644	18	with	with	IN
cord-012418-6ralcn8p	644	19	cellular	cellular	JJ
cord-012418-6ralcn8p	644	20	interferon	interferon	NN
cord-012418-6ralcn8p	644	21	regulatory	regulatory	JJ
cord-012418-6ralcn8p	644	22	factors	factor	NNS
cord-012418-6ralcn8p	644	23	and	and	CC
cord-012418-6ralcn8p	644	24	p300	p300	NN
cord-012418-6ralcn8p	644	25	Viral	Viral	NNP
cord-012418-6ralcn8p	644	26	interferon	interferon	NN
cord-012418-6ralcn8p	644	27	regulatory	regulatory	JJ
cord-012418-6ralcn8p	644	28	factor	factor	NN
cord-012418-6ralcn8p	644	29	1	1	CD
cord-012418-6ralcn8p	644	30	of	of	IN
cord-012418-6ralcn8p	644	31	Kaposi	Kaposi	NNP
cord-012418-6ralcn8p	644	32	's	's	POS
cord-012418-6ralcn8p	644	33	sarcoma	sarcoma	NN
cord-012418-6ralcn8p	644	34	-	-	HYPH
cord-012418-6ralcn8p	644	35	associated	associate	VBN
cord-012418-6ralcn8p	644	36	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	644	37	(	(	-LRB-
cord-012418-6ralcn8p	644	38	human	human	JJ
cord-012418-6ralcn8p	644	39	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	644	40	8)	8)	NNP
cord-012418-6ralcn8p	644	41	binds	bind	VBZ
cord-012418-6ralcn8p	644	42	to	to	IN
cord-012418-6ralcn8p	644	43	,	,	,
cord-012418-6ralcn8p	644	44	and	and	CC
cord-012418-6ralcn8p	644	45	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	644	46	transactivation	transactivation	NN
cord-012418-6ralcn8p	644	47	of	of	IN
cord-012418-6ralcn8p	644	48	,	,	,
cord-012418-6ralcn8p	644	49	CREB	CREB	NNP
cord-012418-6ralcn8p	644	50	-	-	HYPH
cord-012418-6ralcn8p	644	51	binding	bind	VBG
cord-012418-6ralcn8p	644	52	protein	protein	NN
cord-012418-6ralcn8p	645	1	HHV-8	HHV-8	NNP
cord-012418-6ralcn8p	645	2	encoded	encode	VBD
cord-012418-6ralcn8p	645	3	vIRF-1	virf-1	CD
cord-012418-6ralcn8p	646	1	represses	repress	VBZ
cord-012418-6ralcn8p	646	2	the	the	DT
cord-012418-6ralcn8p	646	3	interferon	interferon	NN
cord-012418-6ralcn8p	646	4	antiviral	antiviral	JJ
cord-012418-6ralcn8p	646	5	response	response	NN
cord-012418-6ralcn8p	646	6	by	by	IN
cord-012418-6ralcn8p	646	7	blocking	block	VBG
cord-012418-6ralcn8p	646	8	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	646	9	recruitment	recruitment	NN
cord-012418-6ralcn8p	646	10	of	of	IN
cord-012418-6ralcn8p	646	11	the	the	DT
cord-012418-6ralcn8p	646	12	CBP	CBP	NNP
cord-012418-6ralcn8p	646	13	/	/	SYM
cord-012418-6ralcn8p	646	14	p300	p300	NNP
cord-012418-6ralcn8p	646	15	coactivators	coactivators	NNP
cord-012418-6ralcn8p	646	16	Inhibition	Inhibition	NNP
cord-012418-6ralcn8p	646	17	of	of	IN
cord-012418-6ralcn8p	646	18	interferon	interferon	NN
cord-012418-6ralcn8p	646	19	signaling	signal	VBG
cord-012418-6ralcn8p	646	20	by	by	IN
cord-012418-6ralcn8p	646	21	the	the	DT
cord-012418-6ralcn8p	646	22	Kaposi	Kaposi	NNP
cord-012418-6ralcn8p	646	23	's	's	POS
cord-012418-6ralcn8p	646	24	sarcoma	sarcoma	NN
cord-012418-6ralcn8p	646	25	-	-	HYPH
cord-012418-6ralcn8p	646	26	associated	associate	VBN
cord-012418-6ralcn8p	646	27	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	646	28	full	full	JJ
cord-012418-6ralcn8p	646	29	-	-	HYPH
cord-012418-6ralcn8p	646	30	length	length	NN
cord-012418-6ralcn8p	646	31	viral	viral	JJ
cord-012418-6ralcn8p	646	32	interferon	interferon	NN
cord-012418-6ralcn8p	646	33	regulatory	regulatory	JJ
cord-012418-6ralcn8p	646	34	factor	factor	NN
cord-012418-6ralcn8p	646	35	2	2	CD
cord-012418-6ralcn8p	646	36	protein	protein	NN
cord-012418-6ralcn8p	646	37	A	a	NN
cord-012418-6ralcn8p	647	1	Rhesus	Rhesus	NNP
cord-012418-6ralcn8p	647	2	Rhadinovirus	Rhadinovirus	NNP
cord-012418-6ralcn8p	647	3	Viral	Viral	NNP
cord-012418-6ralcn8p	648	1	Interferon	Interferon	NNP
cord-012418-6ralcn8p	648	2	(	(	-LRB-
cord-012418-6ralcn8p	648	3	IFN	IFN	NNP
cord-012418-6ralcn8p	648	4	)	)	-RRB-
cord-012418-6ralcn8p	648	5	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	648	6	Factor	factor	NN
cord-012418-6ralcn8p	648	7	Is	be	VBZ
cord-012418-6ralcn8p	648	8	Virion	virion	NN
cord-012418-6ralcn8p	648	9	Associated	Associated	NNP
cord-012418-6ralcn8p	648	10	and	and	CC
cord-012418-6ralcn8p	648	11	Inhibits	inhibit	VBZ
cord-012418-6ralcn8p	648	12	the	the	DT
cord-012418-6ralcn8p	648	13	Early	early	JJ
cord-012418-6ralcn8p	648	14	IFN	IFN	NNP
cord-012418-6ralcn8p	648	15	Antiviral	Antiviral	NNP
cord-012418-6ralcn8p	648	16	Response	Response	NNP
cord-012418-6ralcn8p	648	17	Biogenesis	Biogenesis	NNP
cord-012418-6ralcn8p	648	18	of	of	IN
cord-012418-6ralcn8p	648	19	non	non	JJ
cord-012418-6ralcn8p	648	20	-	-	JJ
cord-012418-6ralcn8p	648	21	structural	structural	JJ
cord-012418-6ralcn8p	648	22	protein	protein	NN
cord-012418-6ralcn8p	648	23	1	1	CD
cord-012418-6ralcn8p	648	24	(	(	-LRB-
cord-012418-6ralcn8p	648	25	nsp1	nsp1	NNS
cord-012418-6ralcn8p	648	26	)	)	-RRB-
cord-012418-6ralcn8p	648	27	and	and	CC
cord-012418-6ralcn8p	648	28	nsp1-mediated	nsp1-mediated	JJ
cord-012418-6ralcn8p	648	29	type	type	NN
cord-012418-6ralcn8p	649	1	I	-PRON-	PRP
cord-012418-6ralcn8p	649	2	interferon	interferon	VBD
cord-012418-6ralcn8p	649	3	modulation	modulation	NN
cord-012418-6ralcn8p	649	4	in	in	IN
cord-012418-6ralcn8p	649	5	arteriviruses	arteriviruse	NNS
cord-012418-6ralcn8p	649	6	Degradation	degradation	NN
cord-012418-6ralcn8p	649	7	of	of	IN
cord-012418-6ralcn8p	649	8	CREB	CREB	NNP
cord-012418-6ralcn8p	649	9	-	-	HYPH
cord-012418-6ralcn8p	649	10	binding	bind	VBG
cord-012418-6ralcn8p	649	11	protein	protein	NN
cord-012418-6ralcn8p	649	12	and	and	CC
cord-012418-6ralcn8p	649	13	modulation	modulation	NN
cord-012418-6ralcn8p	649	14	of	of	IN
cord-012418-6ralcn8p	649	15	type	type	NN
cord-012418-6ralcn8p	650	1	I	-PRON-	PRP
cord-012418-6ralcn8p	650	2	interferon	interferon	VBD
cord-012418-6ralcn8p	650	3	induction	induction	NN
cord-012418-6ralcn8p	650	4	by	by	IN
cord-012418-6ralcn8p	650	5	the	the	DT
cord-012418-6ralcn8p	650	6	zinc	zinc	NN
cord-012418-6ralcn8p	650	7	finger	finger	NN
cord-012418-6ralcn8p	650	8	motif	motif	NN
cord-012418-6ralcn8p	650	9	of	of	IN
cord-012418-6ralcn8p	650	10	the	the	DT
cord-012418-6ralcn8p	650	11	porcine	porcine	JJ
cord-012418-6ralcn8p	650	12	reproductive	reproductive	JJ
cord-012418-6ralcn8p	650	13	and	and	CC
cord-012418-6ralcn8p	650	14	respiratory	respiratory	JJ
cord-012418-6ralcn8p	650	15	syndrome	syndrome	NN
cord-012418-6ralcn8p	650	16	virus	virus	NN
cord-012418-6ralcn8p	650	17	nsp1alpha	nsp1alpha	:
cord-012418-6ralcn8p	650	18	subunit	subunit	NN
cord-012418-6ralcn8p	650	19	Modulation	modulation	NN
cord-012418-6ralcn8p	650	20	of	of	IN
cord-012418-6ralcn8p	650	21	type	type	NN
cord-012418-6ralcn8p	651	1	I	-PRON-	PRP
cord-012418-6ralcn8p	651	2	interferon	interferon	VBD
cord-012418-6ralcn8p	651	3	induction	induction	NN
cord-012418-6ralcn8p	651	4	by	by	IN
cord-012418-6ralcn8p	651	5	porcine	porcine	JJ
cord-012418-6ralcn8p	651	6	reproductive	reproductive	JJ
cord-012418-6ralcn8p	651	7	and	and	CC
cord-012418-6ralcn8p	651	8	respiratory	respiratory	JJ
cord-012418-6ralcn8p	651	9	syndrome	syndrome	NN
cord-012418-6ralcn8p	651	10	virus	virus	NN
cord-012418-6ralcn8p	651	11	and	and	CC
cord-012418-6ralcn8p	651	12	degradation	degradation	NN
cord-012418-6ralcn8p	651	13	of	of	IN
cord-012418-6ralcn8p	651	14	CREB	CREB	NNP
cord-012418-6ralcn8p	651	15	-	-	HYPH
cord-012418-6ralcn8p	651	16	binding	bind	VBG
cord-012418-6ralcn8p	651	17	protein	protein	NN
cord-012418-6ralcn8p	651	18	by	by	IN
cord-012418-6ralcn8p	651	19	non	non	JJ
cord-012418-6ralcn8p	651	20	-	-	JJ
cord-012418-6ralcn8p	651	21	structural	structural	JJ
cord-012418-6ralcn8p	651	22	protein	protein	NN
cord-012418-6ralcn8p	651	23	1	1	CD
cord-012418-6ralcn8p	651	24	in	in	IN
cord-012418-6ralcn8p	651	25	MARC-145	MARC-145	NNP
cord-012418-6ralcn8p	651	26	and	and	CC
cord-012418-6ralcn8p	651	27	HeLa	HeLa	NNP
cord-012418-6ralcn8p	651	28	Cells	Cells	NNP
cord-012418-6ralcn8p	651	29	Suppression	Suppression	NNP
cord-012418-6ralcn8p	651	30	of	of	IN
cord-012418-6ralcn8p	651	31	type	type	NN
cord-012418-6ralcn8p	652	1	I	-PRON-	PRP
cord-012418-6ralcn8p	652	2	interferon	interferon	VBD
cord-012418-6ralcn8p	652	3	production	production	NN
cord-012418-6ralcn8p	652	4	by	by	IN
cord-012418-6ralcn8p	652	5	porcine	porcine	JJ
cord-012418-6ralcn8p	652	6	epidemic	epidemic	NN
cord-012418-6ralcn8p	652	7	diarrhea	diarrhea	NN
cord-012418-6ralcn8p	652	8	virus	virus	NN
cord-012418-6ralcn8p	652	9	and	and	CC
cord-012418-6ralcn8p	652	10	degradation	degradation	NN
cord-012418-6ralcn8p	652	11	of	of	IN
cord-012418-6ralcn8p	652	12	CREB	CREB	NNP
cord-012418-6ralcn8p	652	13	-	-	HYPH
cord-012418-6ralcn8p	652	14	binding	bind	VBG
cord-012418-6ralcn8p	652	15	protein	protein	NN
cord-012418-6ralcn8p	652	16	by	by	IN
cord-012418-6ralcn8p	652	17	nsp1	nsp1	NNP
cord-012418-6ralcn8p	652	18	Human	human	JJ
cord-012418-6ralcn8p	652	19	bocavirus	bocavirus	NN
cord-012418-6ralcn8p	652	20	NP1	np1	NN
cord-012418-6ralcn8p	652	21	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	652	22	IFN	IFN	NNP
cord-012418-6ralcn8p	652	23	-	-	HYPH
cord-012418-6ralcn8p	652	24	β	β	NN
cord-012418-6ralcn8p	652	25	production	production	NN
cord-012418-6ralcn8p	652	26	by	by	IN
cord-012418-6ralcn8p	652	27	blocking	block	VBG
cord-012418-6ralcn8p	652	28	association	association	NN
cord-012418-6ralcn8p	652	29	of	of	IN
cord-012418-6ralcn8p	652	30	IFN	IFN	NNP
cord-012418-6ralcn8p	652	31	regulatory	regulatory	JJ
cord-012418-6ralcn8p	652	32	factor	factor	NN
cord-012418-6ralcn8p	652	33	3	3	CD
cord-012418-6ralcn8p	652	34	with	with	IN
cord-012418-6ralcn8p	652	35	IFNB	IFNB	NNP
cord-012418-6ralcn8p	652	36	promoter	promoter	NN
cord-012418-6ralcn8p	653	1	HSV-2	hsv-2	VB
cord-012418-6ralcn8p	653	2	immediate	immediate	JJ
cord-012418-6ralcn8p	653	3	-	-	HYPH
cord-012418-6ralcn8p	653	4	early	early	JJ
cord-012418-6ralcn8p	653	5	protein	protein	NN
cord-012418-6ralcn8p	653	6	US1	US1	NNP
cord-012418-6ralcn8p	653	7	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	653	8	IFN	IFN	NNP
cord-012418-6ralcn8p	653	9	-	-	HYPH
cord-012418-6ralcn8p	653	10	β	β	NN
cord-012418-6ralcn8p	653	11	production	production	NN
cord-012418-6ralcn8p	653	12	by	by	IN
cord-012418-6ralcn8p	653	13	suppressing	suppress	VBG
cord-012418-6ralcn8p	653	14	association	association	NN
cord-012418-6ralcn8p	653	15	of	of	IN
cord-012418-6ralcn8p	653	16	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	653	17	with	with	IN
cord-012418-6ralcn8p	653	18	IFN	IFN	NNP
cord-012418-6ralcn8p	653	19	-	-	HYPH
cord-012418-6ralcn8p	653	20	β	β	NNP
cord-012418-6ralcn8p	653	21	promoter	promoter	NN
cord-012418-6ralcn8p	653	22	NSs	NSs	NNP
cord-012418-6ralcn8p	653	23	Protein	Protein	NNP
cord-012418-6ralcn8p	653	24	of	of	IN
cord-012418-6ralcn8p	653	25	Sandfly	Sandfly	NNP
cord-012418-6ralcn8p	653	26	Fever	Fever	NNP
cord-012418-6ralcn8p	654	1	Sicilian	Sicilian	NNP
cord-012418-6ralcn8p	654	2	Phlebovirus	Phlebovirus	NNP
cord-012418-6ralcn8p	654	3	Counteracts	counteract	VBZ
cord-012418-6ralcn8p	655	1	Interferon	Interferon	NNP
cord-012418-6ralcn8p	655	2	(	(	-LRB-
cord-012418-6ralcn8p	655	3	IFN	IFN	NNP
cord-012418-6ralcn8p	655	4	)	)	-RRB-
cord-012418-6ralcn8p	655	5	Induction	induction	NN
cord-012418-6ralcn8p	655	6	by	by	IN
cord-012418-6ralcn8p	655	7	Masking	mask	VBG
cord-012418-6ralcn8p	655	8	the	the	DT
cord-012418-6ralcn8p	655	9	DNA	dna	NN
cord-012418-6ralcn8p	655	10	-	-	HYPH
cord-012418-6ralcn8p	655	11	Binding	bind	VBG
cord-012418-6ralcn8p	655	12	Domain	domain	NN
cord-012418-6ralcn8p	655	13	of	of	IN
cord-012418-6ralcn8p	655	14	IFN	IFN	NNP
cord-012418-6ralcn8p	655	15	Regulatory	Regulatory	NNP
cord-012418-6ralcn8p	655	16	Factor	Factor	NNP
cord-012418-6ralcn8p	655	17	3	3	CD
cord-012418-6ralcn8p	655	18	Recruitment	Recruitment	NNP
cord-012418-6ralcn8p	655	19	of	of	IN
cord-012418-6ralcn8p	655	20	activated	activate	VBN
cord-012418-6ralcn8p	655	21	IRF-3	IRF-3	NNP
cord-012418-6ralcn8p	655	22	and	and	CC
cord-012418-6ralcn8p	655	23	CBP	CBP	NNP
cord-012418-6ralcn8p	655	24	/	/	SYM
cord-012418-6ralcn8p	655	25	p300	p300	NNP
cord-012418-6ralcn8p	655	26	to	to	IN
cord-012418-6ralcn8p	655	27	herpes	herpes	NNP
cord-012418-6ralcn8p	656	1	simplex	simplex	NNP
cord-012418-6ralcn8p	656	2	virus	virus	NN
cord-012418-6ralcn8p	656	3	ICP0	ICP0	NNP
cord-012418-6ralcn8p	656	4	nuclear	nuclear	JJ
cord-012418-6ralcn8p	656	5	foci	foci	NN
cord-012418-6ralcn8p	656	6	:	:	:
cord-012418-6ralcn8p	657	1	Potential	potential	JJ
cord-012418-6ralcn8p	657	2	role	role	NN
cord-012418-6ralcn8p	657	3	in	in	IN
cord-012418-6ralcn8p	657	4	blocking	block	VBG
cord-012418-6ralcn8p	657	5	IFN	IFN	NNP
cord-012418-6ralcn8p	657	6	-	-	HYPH
cord-012418-6ralcn8p	657	7	beta	beta	NN
cord-012418-6ralcn8p	657	8	induction	induction	NN
cord-012418-6ralcn8p	657	9	Bovine	bovine	JJ
cord-012418-6ralcn8p	657	10	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	657	11	1	1	CD
cord-012418-6ralcn8p	657	12	immediate	immediate	JJ
cord-012418-6ralcn8p	657	13	-	-	HYPH
cord-012418-6ralcn8p	657	14	early	early	JJ
cord-012418-6ralcn8p	657	15	protein	protein	NN
cord-012418-6ralcn8p	657	16	(	(	-LRB-
cord-012418-6ralcn8p	657	17	bICP0	bicp0	NN
cord-012418-6ralcn8p	657	18	)	)	-RRB-
cord-012418-6ralcn8p	657	19	interacts	interact	VBZ
cord-012418-6ralcn8p	657	20	with	with	IN
cord-012418-6ralcn8p	657	21	the	the	DT
cord-012418-6ralcn8p	657	22	histone	histone	NN
cord-012418-6ralcn8p	657	23	acetyltransferase	acetyltransferase	NNP
cord-012418-6ralcn8p	657	24	p300	p300	NNP
cord-012418-6ralcn8p	657	25	,	,	,
cord-012418-6ralcn8p	657	26	which	which	WDT
cord-012418-6ralcn8p	657	27	stimulates	stimulate	VBZ
cord-012418-6ralcn8p	657	28	productive	productive	JJ
cord-012418-6ralcn8p	657	29	infection	infection	NN
cord-012418-6ralcn8p	657	30	and	and	CC
cord-012418-6ralcn8p	658	1	gC	gC	NNP
cord-012418-6ralcn8p	658	2	promoter	promoter	NN
cord-012418-6ralcn8p	658	3	activity	activity	NN
cord-012418-6ralcn8p	658	4	Epstein	Epstein	NNP
cord-012418-6ralcn8p	658	5	-	-	HYPH
cord-012418-6ralcn8p	658	6	Barr	Barr	NNP
cord-012418-6ralcn8p	658	7	virus	virus	NN
cord-012418-6ralcn8p	658	8	BGLF4	bglf4	NN
cord-012418-6ralcn8p	658	9	kinase	kinase	NN
cord-012418-6ralcn8p	658	10	suppresses	suppress	VBZ
cord-012418-6ralcn8p	658	11	the	the	DT
cord-012418-6ralcn8p	658	12	interferon	interferon	NN
cord-012418-6ralcn8p	658	13	regulatory	regulatory	JJ
cord-012418-6ralcn8p	658	14	factor	factor	NN
cord-012418-6ralcn8p	658	15	3	3	CD
cord-012418-6ralcn8p	658	16	signaling	signal	VBG
cord-012418-6ralcn8p	658	17	pathway	pathway	NN
cord-012418-6ralcn8p	659	1	Kaposi	Kaposi	NNP
cord-012418-6ralcn8p	659	2	sarcoma	sarcoma	NN
cord-012418-6ralcn8p	659	3	-	-	HYPH
cord-012418-6ralcn8p	659	4	associated	associate	VBN
cord-012418-6ralcn8p	659	5	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	659	6	latency	latency	NN
cord-012418-6ralcn8p	659	7	-	-	HYPH
cord-012418-6ralcn8p	659	8	associated	associate	VBN
cord-012418-6ralcn8p	659	9	nuclear	nuclear	JJ
cord-012418-6ralcn8p	659	10	antigen	antigen	NN
cord-012418-6ralcn8p	659	11	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	659	12	interferon	interferon	NN
cord-012418-6ralcn8p	659	13	(	(	-LRB-
cord-012418-6ralcn8p	659	14	IFN	IFN	NNP
cord-012418-6ralcn8p	659	15	)	)	-RRB-
cord-012418-6ralcn8p	659	16	beta	beta	JJ
cord-012418-6ralcn8p	659	17	expression	expression	NN
cord-012418-6ralcn8p	659	18	by	by	IN
cord-012418-6ralcn8p	659	19	competing	compete	VBG
cord-012418-6ralcn8p	659	20	with	with	IN
cord-012418-6ralcn8p	659	21	IFN	IFN	NNP
cord-012418-6ralcn8p	659	22	regulatory	regulatory	JJ
cord-012418-6ralcn8p	659	23	factor-3	factor-3	NNP
cord-012418-6ralcn8p	659	24	for	for	IN
cord-012418-6ralcn8p	659	25	binding	bind	VBG
cord-012418-6ralcn8p	659	26	to	to	IN
cord-012418-6ralcn8p	659	27	IFNB	IFNB	NNP
cord-012418-6ralcn8p	659	28	promoter	promoter	NN
cord-012418-6ralcn8p	659	29	Human	Human	NNP
cord-012418-6ralcn8p	659	30	Cytomegalovirus	Cytomegalovirus	NNP
cord-012418-6ralcn8p	659	31	DNA	DNA	NNP
cord-012418-6ralcn8p	659	32	Polymerase	Polymerase	NNP
cord-012418-6ralcn8p	659	33	Subunit	Subunit	NNP
cord-012418-6ralcn8p	659	34	UL44	UL44	NNP
cord-012418-6ralcn8p	659	35	Antagonizes	antagonize	VBZ
cord-012418-6ralcn8p	659	36	Antiviral	Antiviral	NNP
cord-012418-6ralcn8p	659	37	Immune	Immune	NNP
cord-012418-6ralcn8p	659	38	Responses	response	NNS
cord-012418-6ralcn8p	659	39	by	by	IN
cord-012418-6ralcn8p	659	40	Suppressing	suppress	VBG
cord-012418-6ralcn8p	659	41	IRF3-and	IRF3-and	NNP
cord-012418-6ralcn8p	659	42	NF	NF	NNP
cord-012418-6ralcn8p	659	43	-	-	HYPH
cord-012418-6ralcn8p	659	44	kappaB	kappaB	NNP
cord-012418-6ralcn8p	659	45	-	-	HYPH
cord-012418-6ralcn8p	659	46	Mediated	mediate	VBN
cord-012418-6ralcn8p	659	47	Transcription	Transcription	NNP
cord-012418-6ralcn8p	659	48	Binding	Binding	NNP
cord-012418-6ralcn8p	659	49	of	of	IN
cord-012418-6ralcn8p	659	50	Kaposi	Kaposi	NNP
cord-012418-6ralcn8p	659	51	's	's	POS
cord-012418-6ralcn8p	659	52	sarcoma	sarcoma	NN
cord-012418-6ralcn8p	659	53	-	-	HYPH
cord-012418-6ralcn8p	659	54	associated	associate	VBN
cord-012418-6ralcn8p	659	55	herpesvirus	herpesvirus	NN
cord-012418-6ralcn8p	659	56	K	K	NNP
cord-012418-6ralcn8p	659	57	-	-	HYPH
cord-012418-6ralcn8p	659	58	bZIP	bzip	JJ
cord-012418-6ralcn8p	659	59	to	to	IN
cord-012418-6ralcn8p	659	60	interferon	interferon	NN
cord-012418-6ralcn8p	659	61	-	-	HYPH
cord-012418-6ralcn8p	659	62	responsive	responsive	JJ
cord-012418-6ralcn8p	659	63	factor	factor	NN
cord-012418-6ralcn8p	659	64	3	3	CD
cord-012418-6ralcn8p	659	65	elements	element	NNS
cord-012418-6ralcn8p	659	66	modulates	modulate	VBZ
cord-012418-6ralcn8p	659	67	antiviral	antiviral	JJ
cord-012418-6ralcn8p	659	68	gene	gene	NN
cord-012418-6ralcn8p	659	69	expression	expression	NN
cord-012418-6ralcn8p	660	1	A	a	DT
cord-012418-6ralcn8p	660	2	SAP30	SAP30	NNP
cord-012418-6ralcn8p	660	3	complex	complex	NN
cord-012418-6ralcn8p	660	4	inhibits	inhibit	VBZ
cord-012418-6ralcn8p	660	5	IFN	IFN	NNP
cord-012418-6ralcn8p	660	6	-	-	HYPH
cord-012418-6ralcn8p	660	7	beta	beta	JJ
cord-012418-6ralcn8p	660	8	expression	expression	NN
cord-012418-6ralcn8p	660	9	in	in	IN
cord-012418-6ralcn8p	660	10	Rift	Rift	NNP
cord-012418-6ralcn8p	660	11	Valley	Valley	NNP
cord-012418-6ralcn8p	660	12	fever	fever	NN
cord-012418-6ralcn8p	660	13	virus	virus	NN
cord-012418-6ralcn8p	660	14	infected	infect	VBN
cord-012418-6ralcn8p	660	15	Cells	cell	NNS
cord-012418-6ralcn8p	661	1	We	-PRON-	PRP
cord-012418-6ralcn8p	661	2	would	would	MD
cord-012418-6ralcn8p	661	3	like	like	VB
cord-012418-6ralcn8p	661	4	to	to	TO
cord-012418-6ralcn8p	661	5	thank	thank	VB
cord-012418-6ralcn8p	661	6	Friedemann	Friedemann	NNP
cord-012418-6ralcn8p	661	7	Weber	Weber	NNP
cord-012418-6ralcn8p	661	8	for	for	IN
cord-012418-6ralcn8p	661	9	critically	critically	RB
cord-012418-6ralcn8p	661	10	reading	read	VBG
cord-012418-6ralcn8p	661	11	the	the	DT
cord-012418-6ralcn8p	661	12	manuscript	manuscript	NN
cord-012418-6ralcn8p	661	13	.	.	.
cord-012418-6ralcn8p	662	1	We	-PRON-	PRP
cord-012418-6ralcn8p	662	2	would	would	MD
cord-012418-6ralcn8p	662	3	Viruses	virus	NNS
cord-012418-6ralcn8p	662	4	2020	2020	CD
cord-012418-6ralcn8p	662	5	,	,	,
cord-012418-6ralcn8p	662	6	12	12	CD
cord-012418-6ralcn8p	662	7	 	 	_SP