id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352007-3djwbivp	Xiang, Qi	Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication	2020-07-14		.txt	text/plain	6873	353	48	Here, we primarily found that Beclin1 facilitates EV71 replication in human rhabdomyosarcoma (RD) cells and the autophagy was actually induced, but Beclin1 was not significantly affected at either mRNA level or protein level during early EV71 infection. The results show that the mRNA level and protein level of Beclin1 were significantly reduced in RD cells; moreover, knockdown of BECN1 inhibited EV71 replication ( Figure 3A,B) . Our group has previously reported several host factors regulating EV71 replication; for example, SIRT1 can inhibit EV71 replication and RNA translation by interfering with the viral polymerase and 5 UTR RNA [57] , and PolyC-Binding Protein 1 interacts with 5 -untranslated region of EV71 RNA in membrane-associated complex to facilitate viral replication [58] . In FMDV (Foot-and-mouth disease virus)-infected cells, the largest viral protein in the replication complex, 2C, would bind to Beclin1 to prevent the fusion of lysosomes to autophagosomes, allowing for virus survival [35] .	./cache/cord-352007-3djwbivp.txt	./txt/cord-352007-3djwbivp.txt