id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341968-uc8i9h0m	Izaguirre, Gonzalo	The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases	2019-09-09		.txt	text/plain	7870	410	45	A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Like other enveloped viruses that rely on surface glycoproteins for binding and fusion, coronaviruses have the Spike (S) protein, which is cleaved by proteases during virion biosynthesis, as well as during entry into target cells [53] . The location of furin and related PCs in the vesicles of the constitutive protein secretion pathway, where viruses are assembled during morphogenesis or disassembled during cell entry, explains why a diversity of virus types have evolutionarily converged to depend on PCs. Viruses also use other types of proteases for the proteolytic regulation of the binding and fusion functions; however, proteases are restricted to specific cell types, which limits the range of the viral infection, so when some viruses mutate and acquire PC reactivity, they may expand their cell tropism and become more pathogenic.	./cache/cord-341968-uc8i9h0m.txt	./txt/cord-341968-uc8i9h0m.txt