id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337339-0vkigjv2	Osterrieder, Nikolaus	Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters	2020-07-20		.txt	text/plain	4327	220	47	We propose that comparative assessment in young versus aged hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information, as this small-animal model appears to mirror age-dependent differences in human patients. Moreover, transgenic mice expressing human ACE2 represent a lethal SARS-CoV-2 infection model resulting in significant weight loss and permitting robust virus replication in the respiratory tract including the lungs [20] . In contrast to SARS-CoV-2 titers, histopathological changes differed markedly between young and aged Syrian hamsters over time: younger animals launched more severe reactions at early time points after infection, while lesions and inflammation in the lungs became more pronounced and widespread at later time points in the elderly. Based on the data presented here, we propose that comparative preclinical assessments of SARS-CoV-2 vaccines and other treatment options in young versus aged hamsters may yield valuable and relevant results, as this small animal model appears to mimic age-dependent differences in humans.	./cache/cord-337339-0vkigjv2.txt	./txt/cord-337339-0vkigjv2.txt