id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321673-v5o49ees	Nieto-Torres, Jose L.	Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis	2015-07-03		.txt	text/plain	8398	451	38	Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Noticeably, these proteins oligomerize in cell membranes to form ion conductive pores, which generally display mild ion selectivity, indicating that viroporins do not show preference for particular ionic species. Influenza viruses lacking M2 ion conductivity, presented either a 15-fold reduction of viral titer in tissue culture [74] , or showed a standard production in cell culture but a restricted growth in the nasal turbinates of infected mice [75] . Several compounds inhibit viroporin ion conductivity in artificial lipid membranes, and some of them efficiently reduce viral growth when administered to infected cells. Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells	./cache/cord-321673-v5o49ees.txt	./txt/cord-321673-v5o49ees.txt