id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321013-8pkrg0mx	McBride, Ruth	The Coronavirus Nucleocapsid Is a Multifunctional Protein	2014-08-07		.txt	text/plain	10761	476	44	The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. The M protein is the main core shell component and a 16 amino acid domain (aa 237-252) on the CTD of M protein binds directly to N protein via an ionic interaction, leading to specific genome encapsidation in the budding viral particle [81] [82] [83] .The N protein therefore plays an essential structural role in the CoV virion through a network of interactions with (i) the genomic RNA; (ii) M protein and (iii) other N proteins. Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA	./cache/cord-321013-8pkrg0mx.txt	./txt/cord-321013-8pkrg0mx.txt