id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294347-axkdf5vu	Kim, Shin-Hee	Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines	2016-07-04		.txt	text/plain	7189	353	44	Specifically, vectored vaccines can have advantages for (i) viruses for which a live attenuated vaccine might not be feasible (i.e., HIV); (ii) viruses that do not grow well in vitro (i.e., human papillomavirus, hepatitis C virus, and norovirus); (iii) highly pathogenic viruses that present safety challenges during vaccine development (i.e., SARS-CoV and Ebola virus); (iv) viruses that lose infectivity due to physical instability (i.e., respiratory syncytial virus (RSV)); and (v) viruses that can exchange genes with circulating viruses (i.e., coronaviruses, influenza viruses, and enteroviruses) [4] . Further, immunized mice by the intravenous route were completely protected against a lethal dose of influenza virus, suggesting that NDV can be a safe and effective vaccine vector for possible use in mammalian and avian species. Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus	./cache/cord-294347-axkdf5vu.txt	./txt/cord-294347-axkdf5vu.txt