id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294125-v2dr4hm0	Albert, Manuel	ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial Homeostasis	2018-11-13		.txt	text/plain	8040	444	33	Finally, based on our recent observations, we discuss the essential functions of mitochondria in the antiviral response and examine the role of ISG15 in the regulation of mitochondrial processes, specifically OXPHOS and mitophagy. Binding to IFNARs leads to the activation of the Janus kinase-signal transducer and activator of transcription proteins (JAK-STAT) signaling pathway and the formation of the interferon-stimulated gene factor 3 (ISGF3) complex, with the subsequent expression of IFN-stimulated genes [3] that establish an antiviral state and play important roles in determining the host innate and adaptive immune responses [4] . In the following sections, we discuss the antiviral mechanisms mediated by ISGylation of both viral and cellular proteins, with a focus on mitochondrial proteins, as we recently showed that ISG15 modulates essential mitochondrial metabolic processes such as respiration and mitophagy in macrophages, with important implications for innate immune responses [29] .	./cache/cord-294125-v2dr4hm0.txt	./txt/cord-294125-v2dr4hm0.txt