id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273366-xd84f8ct	Brownsword, Matthew J.	Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling	2020-05-14		.txt	text/plain	8910	520	47	Interestingly, we found that IBV is able to inhibit multiple cellular stress granule signaling pathways, whilst at the same time, IBV replication also results in the induction of seemingly canonical stress granules in a proportion of infected cells. Moreover, IBV infection uncouples translational repression and stress granule formation and both processes are independent of eIF2α phosphorylation. Vero cells were infected with IBV and at the indicated time points, cells were fixed and labelled with anti-dsRNA to detect virus infection and with anti-G3BP1 to detect SG. Following identification of SG in IBV infected cells, the requirement for active virus replication in induction of granules was assessed. At 24 hpi, cells were fixed and labelled with anti-G3BP1 (red) to detect stress granules (SG) and IBV infected cells were detected with an anti-dsRNA antibody (green). Junin virus infection impairs stress-granule formation in Vero cells treated with arsenite via inhibition of eIF2alpha phosphorylation	./cache/cord-273366-xd84f8ct.txt	./txt/cord-273366-xd84f8ct.txt