id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261417-4pf5nsw2	Harwig, Alex	The Battle of RNA Synthesis: Virus versus Host	2017-10-21		.txt	text/plain	7864	443	53	Why the virus prefers to use these snRNAs as targets has yet to be experimentally established, but it has been proposed that the selective de-capping of U1 and U2 RNAs in combination with the binding of the viral NS1 protein to U6 snRNA may serve to inhibit host pre-mRNA splicing [66] . The folding of the TAR hairpin is key to the regulation of HIV-1 transcription [94] as it is used as a scaffold to recruit essential transcription factors, including the 86-101 amino acid (aa) viral trans-activator protein (Tat) [83] ( Figure 3C ). Interestingly, the human T-lymphotropic virus type 1 transcriptional activator Tax also utilizes P-TEFb for viral transcription and displaces P-TEFb from 7SK snRNP through binding CycT1 [101, 102] , suggesting that P-TEFb liberation from 7SK snRNP could be a common theme developed by different viruses to support their replication in host cells.	./cache/cord-261417-4pf5nsw2.txt	./txt/cord-261417-4pf5nsw2.txt