id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259237-aty0vrat	Frabutt, Dylan A.	Arms Race between Enveloped Viruses and the Host ERAD Machinery	2016-09-19		.txt	text/plain	9770	508	42	One important arm of UPR is to elevate the capacity of the ER-associated protein degradation (ERAD) pathway, which is comprised of host quality control machinery that ensures proper protein folding. The remaining Man residues are cleaved by the Golgi mannosidases, and the glycan remolding process is continued through the remainder of the N-glycosylation pathway, which generates functional glycoproteins that are delivered to the cell surface ( Figure 1B ). As introduced earlier, the UPR utilizes three different mechanisms to alleviate ER stress: reducing global protein translation, increasing the ER folding capacity, and enhancing ERAD by activating the PERK, ATF6, or IRE1-XBP1 pathways, respectively. ERManI also targets the terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK) for degradation via ERAD, but neither its catalytic activity nor its catalytic domain is required for this degradation, suggesting that different mechanisms are involved in HIV-1 Env and NHK degradation [152] . The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway	./cache/cord-259237-aty0vrat.txt	./txt/cord-259237-aty0vrat.txt