id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257913-uf9sx5qi	Dijkman, Ronald	Seroconversion to HCoV-NL63 in Rhesus Macaques	2009-10-30		.txt	text/plain	2794	155	57	Alternatively, one can establish whether rhesus macaques that are in close contact to humans have experienced a natural HCoV-NL63 infection by investigating the NL63-directed antibody titers in time. In the current study we use the kinetics of the antibody response to HCoV-NL63 to determine whether rhesus macaques encounter natural infections with HCoV-NL63, or related coronaviruses. The first indication of infections with HCoV-NL63-like viruses in rhesus macaques was found when we tested 32 serum samples of 32 monkeys (Table 1 and Figure 1 ). Longitudinal serum samples were available of three rhesus macaques with the highest antibody levels to HCoV-NL63 (numbers 5, 10 and 17). A well-designed follow up through the years with serum and respiratory samples collected on a regular basis would be sufficient to unravel the potential of the human respiratory viruses to infect rhesus macaques. We show here that there are clear signs that Rhesus macaques acquire natural infections with HCoV-NL63, or a serologically very closely related coronavirus.	./cache/cord-257913-uf9sx5qi.txt	./txt/cord-257913-uf9sx5qi.txt