id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012420-llh22iq2	Stott, Robert J.	Distinct Molecular Mechanisms of Host Immune Response Modulation by Arenavirus NP and Z Proteins	2020-07-21		.txt	text/plain	12015	579	41	Interestingly, non-pathogenic OW Mopeia virus (MOPV), a close genetic relative to LASV, induces a strong initial IFN and cytokine response in infected moDCs and macrophages leading to a sustained T cell activation and immune response [67, 68] . Similar to NP, interaction of arenavirus Z proteins with RIG-I prevents further binding to MAVS and therefore inhibits the production of IFN-β and reduces antiviral host immune responses. Although the inhibition of RIG-I signalling by highly pathogenic arenaviruses in vitro suggests that there should be limited IFN1 response, it is notable that in vivo infection with some of these viruses (LCMV, JUNV) induces high levels of IFN1, ISGs and cytokines suggesting that this strategy is not completely effective or is widely varied in cell type and differs from host to host [134, 135, 186] .	./cache/cord-012420-llh22iq2.txt	./txt/cord-012420-llh22iq2.txt