id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004018-33zi29bg	Coombs, Kevin M.	Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses	2019-11-05		.txt	text/plain	5373	252	43	We used a newly-developed aptamer-based multiplexed technique (SOMAscan(®)) to examine >1300 human lung cell proteins affected by the different IAV strains, and identified more than 500 significantly dysregulated cellular proteins. The PR8 strain induced a general activation, primarily by upregulating many immune molecules, the seasonal RV733 and pdm09 strains had minimal effect upon assayed molecules, and the avian strains induced significant downregulation, primarily in antimicrobial response, cardiovascular and post-translational modification systems. We found that the culture-adapted PR8 strain had an overall activation of immune molecules, the mild seasonal and pdm09 human strains had little effect upon the molecules targeted by the SOMA panel, and the avian H5N1 and H7N9 strains, that are much more pathogenic in humans, had the most dramatic proteomic responses, these upregulating a few tested molecules, but inhibiting many more key cellular processes. Quantitative proteomic analyses of influenza virus-infected cultured human lung cells Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines	./cache/cord-004018-33zi29bg.txt	./txt/cord-004018-33zi29bg.txt