id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003865-24lz9tf1	Zhou, Hongzhuan	Inhibitory Effects of Antiviral Drug Candidates on Canine Parvovirus in F81 cells	2019-08-13		.txt	text/plain	5582	281	50	To evaluate the antiviral effects of the three drugs of Nitazoxanide, Closantel Sodium and Closantel, F81 cells were seeded in 6-well plates at 7.5 × 10 5 cells per well and pretreated with the 3 drugs at a final concentrations of 5 µM, 10 µM, and 20 µM, respectively, for 1 h, then treated cells were infected with CPV at MOI of 0.076 as described above. As mentioned above, the identified drugs Nitazoxanide, Closantel Sodium, and Closantel can reduce the copy numbers of CPV viral DNA to 0.07%, 24.04%, and 20.83%, respectively, compared with the 0.1% DMSO-treated control ( Figure 3) . Our CPE-based screening assay showed that the percentage CPE inhibition of Oseltamivir and Cidofovir were 2.13 ± 2.41 and −1.28 ± 1.03 (Table S1 ), respectively, and that these two drugs had no anti-CPV effects on F81 cells.	./cache/cord-003865-24lz9tf1.txt	./txt/cord-003865-24lz9tf1.txt