id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003761-ikni2acz	Li, Zengbin	Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development	2019-06-04		.txt	text/plain	6425	331	39	In this review, we mainly summarize recent research data on the viroporin or viroporin-like activity of 2B proteins, which affects the biological function of the membrane, regulates cell death, and affects the host immune response. In particular, the 2B protein may change the Ca 2+ concentration to regulate autophagy and apoptosiswhich are distinct cell death mechanisms controlled by the virus to effectively evade the host immunity, thereby promoting viral replication and release [48] [49] [50] [51] [52] . Thus, the main points of focus for research on the structure and function of the 2B protein toward ultimate drug development are: (1) mechanism of increasing membrane permeability to disturb the ion balance, (2) regulation of autophagy and apoptosis, (3) inhibition of the host immune response, and (4) promotion of viral replication and release.	./cache/cord-003761-ikni2acz.txt	./txt/cord-003761-ikni2acz.txt