id author title date pages extension mime words sentences flesch summary cache txt cord-002691-synm1cyw Hou, Jiun-Nan PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication 2017-09-20 .txt text/plain 9842 477 51 title: PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication Results revealed that the TOR signaling pathway may have retained its activity involved in controlling cap-dependent protein translation in C6/36 cells infected by the DENV2. Results revealed that the TOR signaling pathway may have retained its activity involved in controlling cap-dependent protein translation in C6/36 cells infected by the DENV2. This suggested that the PERK signaling pathway is involved in regulating cellular protein translation when ER stress is induced by DENV2 in mosquito cells. This suggested that the PERK signaling pathway is involved in regulating cellular protein translation when ER stress is induced by DENV2 in mosquito cells. In the meantime, PERK inhibition in this study was further shown to increase MMP changes and ROS accumulation, indicating that DENV2-induced ER stress may be reduced by activating the PERK signal pathway since such cellular responses were not evidently shown in uninfected PERKi-treated cells (Figures S1-S3) . ./cache/cord-002691-synm1cyw.txt ./txt/cord-002691-synm1cyw.txt