id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002076-7t4d4vvo	Li, Yongfeng	Applications of Replicating-Competent Reporter-Expressing Viruses in Diagnostic and Molecular Virology	2016-05-06		.txt	text/plain	4996	229	36	Commonly used tests based on wild-type viruses, such as immunostaining, cannot meet the demands for rapid detection of viral replication, high-throughput screening for antivirals, as well as for tracking viral proteins or virus transport in real time. This article reviews the applications of RCREVs in diagnostic and molecular virology, including rapid neutralization tests, high-throughput screening systems, identification of viral receptors and virus-host interactions, dynamics of viral infections in vitro and in vivo, vaccination approaches and others. Replicating-competent reporter-expressing viruses (RCREVs) are one type of artificially modified viruses that not only retain the viral genetic characteristics but also possess the new properties of the reporter genes, which represent a useful tool for quantitative analysis of viral replication and tracking viral protein transport in both living cells and animals.	./cache/cord-002076-7t4d4vvo.txt	./txt/cord-002076-7t4d4vvo.txt