id sid tid token lemma pos cord-332672-fbwz8oxp 1 1 key key NN cord-332672-fbwz8oxp 1 2 : : : cord-332672-fbwz8oxp 1 3 cord-332672-fbwz8oxp cord-332672-fbwz8oxp NNS cord-332672-fbwz8oxp 1 4 authors author NNS cord-332672-fbwz8oxp 1 5 : : : cord-332672-fbwz8oxp 1 6 Wang Wang NNP cord-332672-fbwz8oxp 1 7 , , , cord-332672-fbwz8oxp 1 8 Manli Manli NNP cord-332672-fbwz8oxp 1 9 ; ; : cord-332672-fbwz8oxp 1 10 Hu Hu NNP cord-332672-fbwz8oxp 1 11 , , , cord-332672-fbwz8oxp 2 1 Zhihong Zhihong NNP cord-332672-fbwz8oxp 2 2 title title NN cord-332672-fbwz8oxp 2 3 : : : cord-332672-fbwz8oxp 2 4 Bats bat NNS cord-332672-fbwz8oxp 2 5 as as IN cord-332672-fbwz8oxp 2 6 animal animal NN cord-332672-fbwz8oxp 2 7 reservoirs reservoir NNS cord-332672-fbwz8oxp 2 8 for for IN cord-332672-fbwz8oxp 2 9 the the DT cord-332672-fbwz8oxp 2 10 SARS SARS NNP cord-332672-fbwz8oxp 2 11 coronavirus coronavirus NN cord-332672-fbwz8oxp 2 12 : : : cord-332672-fbwz8oxp 2 13 Hypothesis hypothesis NN cord-332672-fbwz8oxp 2 14 proved prove VBD cord-332672-fbwz8oxp 2 15 after after IN cord-332672-fbwz8oxp 2 16 10 10 CD cord-332672-fbwz8oxp 2 17 years year NNS cord-332672-fbwz8oxp 2 18 of of IN cord-332672-fbwz8oxp 2 19 virus virus NN cord-332672-fbwz8oxp 2 20 hunting hunting NN cord-332672-fbwz8oxp 2 21 date date NN cord-332672-fbwz8oxp 2 22 : : : cord-332672-fbwz8oxp 2 23 2013 2013 CD cord-332672-fbwz8oxp 2 24 - - SYM cord-332672-fbwz8oxp 2 25 10 10 CD cord-332672-fbwz8oxp 2 26 - - SYM cord-332672-fbwz8oxp 2 27 30 30 CD cord-332672-fbwz8oxp 2 28 journal journal NN cord-332672-fbwz8oxp 2 29 : : : cord-332672-fbwz8oxp 3 1 Virol Virol NNP cord-332672-fbwz8oxp 4 1 Sin sin NN cord-332672-fbwz8oxp 4 2 DOI doi NN cord-332672-fbwz8oxp 4 3 : : : cord-332672-fbwz8oxp 5 1 10.1007 10.1007 CD cord-332672-fbwz8oxp 5 2 / / SYM cord-332672-fbwz8oxp 5 3 s12250 s12250 JJ cord-332672-fbwz8oxp 5 4 - - HYPH cord-332672-fbwz8oxp 5 5 013 013 CD cord-332672-fbwz8oxp 5 6 - - HYPH cord-332672-fbwz8oxp 5 7 3402-x 3402-x NNP cord-332672-fbwz8oxp 5 8 sha sha NNP cord-332672-fbwz8oxp 5 9 : : : cord-332672-fbwz8oxp 5 10 ba2f8fec716b16a4bb1257ecef064fddc9d13868 ba2f8fec716b16a4bb1257ecef064fddc9d13868 NNP cord-332672-fbwz8oxp 5 11 doc_id doc_id CD cord-332672-fbwz8oxp 5 12 : : : cord-332672-fbwz8oxp 5 13 332672 332672 CD cord-332672-fbwz8oxp 5 14 cord_uid cord_uid NNS cord-332672-fbwz8oxp 5 15 : : : cord-332672-fbwz8oxp 5 16 fbwz8oxp fbwz8oxp NN cord-332672-fbwz8oxp 6 1 Recently recently RB cord-332672-fbwz8oxp 6 2 , , , cord-332672-fbwz8oxp 6 3 the the DT cord-332672-fbwz8oxp 6 4 team team NN cord-332672-fbwz8oxp 6 5 led lead VBN cord-332672-fbwz8oxp 6 6 by by IN cord-332672-fbwz8oxp 6 7 Dr. Dr. NNP cord-332672-fbwz8oxp 6 8 Zhengli Zhengli NNP cord-332672-fbwz8oxp 6 9 Shi Shi NNP cord-332672-fbwz8oxp 6 10 from from IN cord-332672-fbwz8oxp 6 11 Wuhan Wuhan NNP cord-332672-fbwz8oxp 6 12 Institute Institute NNP cord-332672-fbwz8oxp 6 13 of of IN cord-332672-fbwz8oxp 6 14 Virology Virology NNP cord-332672-fbwz8oxp 6 15 , , , cord-332672-fbwz8oxp 6 16 Chinese Chinese NNP cord-332672-fbwz8oxp 6 17 Academy Academy NNP cord-332672-fbwz8oxp 6 18 of of IN cord-332672-fbwz8oxp 6 19 Sciences Sciences NNPS cord-332672-fbwz8oxp 6 20 , , , cord-332672-fbwz8oxp 6 21 and and CC cord-332672-fbwz8oxp 6 22 Dr. Dr. NNP cord-332672-fbwz8oxp 6 23 Peter Peter NNP cord-332672-fbwz8oxp 6 24 Daszak Daszak NNP cord-332672-fbwz8oxp 6 25 from from IN cord-332672-fbwz8oxp 6 26 Ecohealth Ecohealth NNP cord-332672-fbwz8oxp 6 27 Alliance Alliance NNP cord-332672-fbwz8oxp 6 28 identified identify VBD cord-332672-fbwz8oxp 6 29 SL SL NNP cord-332672-fbwz8oxp 6 30 - - HYPH cord-332672-fbwz8oxp 6 31 CoVs CoVs NNP cord-332672-fbwz8oxp 6 32 in in IN cord-332672-fbwz8oxp 6 33 Chinese chinese JJ cord-332672-fbwz8oxp 6 34 horseshoe horseshoe NN cord-332672-fbwz8oxp 6 35 bats bat NNS cord-332672-fbwz8oxp 6 36 that that WDT cord-332672-fbwz8oxp 6 37 were be VBD cord-332672-fbwz8oxp 6 38 95 95 CD cord-332672-fbwz8oxp 6 39 % % NN cord-332672-fbwz8oxp 6 40 identical identical JJ cord-332672-fbwz8oxp 6 41 to to IN cord-332672-fbwz8oxp 6 42 human human JJ cord-332672-fbwz8oxp 6 43 SARS SARS NNP cord-332672-fbwz8oxp 6 44 - - HYPH cord-332672-fbwz8oxp 6 45 CoV CoV NNP cord-332672-fbwz8oxp 6 46 and and CC cord-332672-fbwz8oxp 6 47 were be VBD cord-332672-fbwz8oxp 6 48 able able JJ cord-332672-fbwz8oxp 6 49 to to TO cord-332672-fbwz8oxp 6 50 use use VB cord-332672-fbwz8oxp 6 51 human human JJ cord-332672-fbwz8oxp 6 52 angiotensin angiotensin NN cord-332672-fbwz8oxp 6 53 - - HYPH cord-332672-fbwz8oxp 6 54 converting convert VBG cord-332672-fbwz8oxp 6 55 enzyme enzyme NN cord-332672-fbwz8oxp 6 56 2 2 CD cord-332672-fbwz8oxp 6 57 ( ( -LRB- cord-332672-fbwz8oxp 6 58 ACE2 ACE2 NNP cord-332672-fbwz8oxp 6 59 ) ) -RRB- cord-332672-fbwz8oxp 6 60 receptor receptor NN cord-332672-fbwz8oxp 6 61 for for IN cord-332672-fbwz8oxp 6 62 docking docking NN cord-332672-fbwz8oxp 6 63 and and CC cord-332672-fbwz8oxp 6 64 entry entry NN cord-332672-fbwz8oxp 6 65 . . . cord-332672-fbwz8oxp 7 1 Remarkably remarkably RB cord-332672-fbwz8oxp 7 2 , , , cord-332672-fbwz8oxp 7 3 they -PRON- PRP cord-332672-fbwz8oxp 7 4 isolated isolate VBD cord-332672-fbwz8oxp 7 5 the the DT cord-332672-fbwz8oxp 7 6 first first RB cord-332672-fbwz8oxp 7 7 known known JJ cord-332672-fbwz8oxp 7 8 live live JJ cord-332672-fbwz8oxp 7 9 bat bat NN cord-332672-fbwz8oxp 7 10 SL SL NNP cord-332672-fbwz8oxp 7 11 - - HYPH cord-332672-fbwz8oxp 7 12 CoV CoV NNP cord-332672-fbwz8oxp 7 13 that that WDT cord-332672-fbwz8oxp 7 14 replicates replicate VBZ cord-332672-fbwz8oxp 7 15 in in IN cord-332672-fbwz8oxp 7 16 human human JJ cord-332672-fbwz8oxp 7 17 and and CC cord-332672-fbwz8oxp 7 18 related related JJ cord-332672-fbwz8oxp 7 19 cells cell NNS cord-332672-fbwz8oxp 7 20 . . . cord-332672-fbwz8oxp 8 1 Their -PRON- PRP$ cord-332672-fbwz8oxp 8 2 findings finding NNS cord-332672-fbwz8oxp 8 3 provide provide VBP cord-332672-fbwz8oxp 8 4 clear clear JJ cord-332672-fbwz8oxp 8 5 evidence evidence NN cord-332672-fbwz8oxp 8 6 that that IN cord-332672-fbwz8oxp 8 7 some some DT cord-332672-fbwz8oxp 8 8 SL sl NN cord-332672-fbwz8oxp 8 9 - - HYPH cord-332672-fbwz8oxp 8 10 CoVs CoVs NNP cord-332672-fbwz8oxp 8 11 circulating circulate VBG cord-332672-fbwz8oxp 8 12 in in IN cord-332672-fbwz8oxp 8 13 bats bat NNS cord-332672-fbwz8oxp 8 14 are be VBP cord-332672-fbwz8oxp 8 15 capable capable JJ cord-332672-fbwz8oxp 8 16 of of IN cord-332672-fbwz8oxp 8 17 infecting infect VBG cord-332672-fbwz8oxp 8 18 and and CC cord-332672-fbwz8oxp 8 19 replicating replicate VBG cord-332672-fbwz8oxp 8 20 in in IN cord-332672-fbwz8oxp 8 21 human human NN cord-332672-fbwz8oxp 9 1 ( ( -LRB- cord-332672-fbwz8oxp 9 2 Ge Ge NNP cord-332672-fbwz8oxp 9 3 X X NNP cord-332672-fbwz8oxp 9 4 Y Y NNP cord-332672-fbwz8oxp 9 5 , , , cord-332672-fbwz8oxp 9 6 et et NNP cord-332672-fbwz8oxp 9 7 al al NNP cord-332672-fbwz8oxp 9 8 . . NNP cord-332672-fbwz8oxp 9 9 , , , cord-332672-fbwz8oxp 9 10 2013 2013 CD cord-332672-fbwz8oxp 9 11 ) ) -RRB- cord-332672-fbwz8oxp 9 12 . . . cord-332672-fbwz8oxp 10 1 SARS SARS NNP cord-332672-fbwz8oxp 10 2 - - HYPH cord-332672-fbwz8oxp 10 3 CoV CoV NNP cord-332672-fbwz8oxp 10 4 remains remain VBZ cord-332672-fbwz8oxp 10 5 elusive elusive JJ cord-332672-fbwz8oxp 10 6 . . . cord-332672-fbwz8oxp 11 1 Although although IN cord-332672-fbwz8oxp 11 2 it -PRON- PRP cord-332672-fbwz8oxp 11 3 is be VBZ cord-332672-fbwz8oxp 11 4 suggested suggest VBN cord-332672-fbwz8oxp 11 5 that that IN cord-332672-fbwz8oxp 11 6 bats bat NNS cord-332672-fbwz8oxp 11 7 are be VBP cord-332672-fbwz8oxp 11 8 the the DT cord-332672-fbwz8oxp 11 9 natural natural JJ cord-332672-fbwz8oxp 11 10 reservoirs reservoir NNS cord-332672-fbwz8oxp 11 11 for for IN cord-332672-fbwz8oxp 11 12 SARS SARS NNP cord-332672-fbwz8oxp 11 13 - - HYPH cord-332672-fbwz8oxp 11 14 CoV CoV NNP cord-332672-fbwz8oxp 11 15 , , , cord-332672-fbwz8oxp 11 16 isolation isolation NN cord-332672-fbwz8oxp 11 17 of of IN cord-332672-fbwz8oxp 11 18 a a DT cord-332672-fbwz8oxp 11 19 SARS SARS NNP cord-332672-fbwz8oxp 11 20 like like IN cord-332672-fbwz8oxp 11 21 virus virus NN cord-332672-fbwz8oxp 11 22 ( ( -LRB- cord-332672-fbwz8oxp 11 23 SL sl NN cord-332672-fbwz8oxp 11 24 - - HYPH cord-332672-fbwz8oxp 11 25 CoV CoV NNP cord-332672-fbwz8oxp 11 26 ) ) -RRB- cord-332672-fbwz8oxp 11 27 from from IN cord-332672-fbwz8oxp 11 28 bats bat NNS cord-332672-fbwz8oxp 11 29 have have VBP cord-332672-fbwz8oxp 11 30 been be VBN cord-332672-fbwz8oxp 11 31 unsuccessful unsuccessful JJ cord-332672-fbwz8oxp 11 32 . . . cord-332672-fbwz8oxp 12 1 To to TO cord-332672-fbwz8oxp 12 2 trace trace VB cord-332672-fbwz8oxp 12 3 the the DT cord-332672-fbwz8oxp 12 4 origin origin NN cord-332672-fbwz8oxp 12 5 of of IN cord-332672-fbwz8oxp 12 6 the the DT cord-332672-fbwz8oxp 12 7 sudden sudden JJ cord-332672-fbwz8oxp 12 8 emerging emerge VBG cord-332672-fbwz8oxp 12 9 SARS SARS NNP cord-332672-fbwz8oxp 12 10 - - HYPH cord-332672-fbwz8oxp 12 11 CoV CoV NNP cord-332672-fbwz8oxp 12 12 , , , cord-332672-fbwz8oxp 12 13 molecular molecular JJ cord-332672-fbwz8oxp 12 14 epidemiological epidemiological JJ cord-332672-fbwz8oxp 12 15 studies study NNS cord-332672-fbwz8oxp 12 16 have have VBP cord-332672-fbwz8oxp 12 17 been be VBN cord-332672-fbwz8oxp 12 18 conducted conduct VBN cord-332672-fbwz8oxp 12 19 by by IN cord-332672-fbwz8oxp 12 20 different different JJ cord-332672-fbwz8oxp 12 21 research research NN cord-332672-fbwz8oxp 12 22 groups group NNS cord-332672-fbwz8oxp 12 23 . . . cord-332672-fbwz8oxp 13 1 In in IN cord-332672-fbwz8oxp 13 2 2003 2003 CD cord-332672-fbwz8oxp 13 3 , , , cord-332672-fbwz8oxp 13 4 Guan Guan NNP cord-332672-fbwz8oxp 13 5 et et NNP cord-332672-fbwz8oxp 13 6 al al NNP cord-332672-fbwz8oxp 13 7 . . . cord-332672-fbwz8oxp 14 1 isolated isolate VBN cord-332672-fbwz8oxp 14 2 SARS SARS NNP cord-332672-fbwz8oxp 14 3 - - HYPH cord-332672-fbwz8oxp 14 4 CoVs CoVs NNP cord-332672-fbwz8oxp 14 5 from from IN cord-332672-fbwz8oxp 14 6 Himalayan Himalayan NNP cord-332672-fbwz8oxp 14 7 palm palm NN cord-332672-fbwz8oxp 14 8 civets civet NNS cord-332672-fbwz8oxp 14 9 and and CC cord-332672-fbwz8oxp 14 10 two two CD cord-332672-fbwz8oxp 14 11 other other JJ cord-332672-fbwz8oxp 14 12 species specie NNS cord-332672-fbwz8oxp 14 13 in in IN cord-332672-fbwz8oxp 14 14 a a DT cord-332672-fbwz8oxp 14 15 live live JJ cord-332672-fbwz8oxp 14 16 - - HYPH cord-332672-fbwz8oxp 14 17 animal animal NN cord-332672-fbwz8oxp 14 18 market market NN cord-332672-fbwz8oxp 14 19 in in IN cord-332672-fbwz8oxp 14 20 Guangdong Guangdong NNP cord-332672-fbwz8oxp 14 21 , , , cord-332672-fbwz8oxp 14 22 China China NNP cord-332672-fbwz8oxp 14 23 ( ( -LRB- cord-332672-fbwz8oxp 14 24 Guan Guan NNP cord-332672-fbwz8oxp 14 25 Y Y NNP cord-332672-fbwz8oxp 14 26 , , , cord-332672-fbwz8oxp 14 27 et et NNP cord-332672-fbwz8oxp 14 28 al al NNP cord-332672-fbwz8oxp 14 29 , , , cord-332672-fbwz8oxp 14 30 2003 2003 CD cord-332672-fbwz8oxp 14 31 ) ) -RRB- cord-332672-fbwz8oxp 14 32 . . . cord-332672-fbwz8oxp 15 1 The the DT cord-332672-fbwz8oxp 15 2 Chinese chinese JJ cord-332672-fbwz8oxp 15 3 SARS SARS NNP cord-332672-fbwz8oxp 15 4 molecular molecular JJ cord-332672-fbwz8oxp 15 5 epidemiology epidemiology NN cord-332672-fbwz8oxp 15 6 consortium consortium NN cord-332672-fbwz8oxp 15 7 suggested suggest VBD cord-332672-fbwz8oxp 15 8 that that IN cord-332672-fbwz8oxp 15 9 the the DT cord-332672-fbwz8oxp 15 10 early early JJ cord-332672-fbwz8oxp 15 11 - - HYPH cord-332672-fbwz8oxp 15 12 phase phase NN cord-332672-fbwz8oxp 15 13 human human JJ cord-332672-fbwz8oxp 15 14 SARS SARS NNP cord-332672-fbwz8oxp 15 15 - - HYPH cord-332672-fbwz8oxp 15 16 CoV cov NN cord-332672-fbwz8oxp 15 17 strains strain NNS cord-332672-fbwz8oxp 15 18 may may MD cord-332672-fbwz8oxp 15 19 have have VB cord-332672-fbwz8oxp 15 20 originated originate VBN cord-332672-fbwz8oxp 15 21 from from IN cord-332672-fbwz8oxp 15 22 wild wild JJ cord-332672-fbwz8oxp 15 23 animals animal NNS cord-332672-fbwz8oxp 15 24 ( ( -LRB- cord-332672-fbwz8oxp 15 25 The the DT cord-332672-fbwz8oxp 15 26 Chinese chinese JJ cord-332672-fbwz8oxp 15 27 SARS SARS NNP cord-332672-fbwz8oxp 15 28 Molecular Molecular NNP cord-332672-fbwz8oxp 15 29 Epidemiology Epidemiology NNP cord-332672-fbwz8oxp 15 30 Consortium Consortium NNP cord-332672-fbwz8oxp 15 31 , , , cord-332672-fbwz8oxp 15 32 2004 2004 CD cord-332672-fbwz8oxp 15 33 ) ) -RRB- cord-332672-fbwz8oxp 15 34 . . . cord-332672-fbwz8oxp 16 1 These these DT cord-332672-fbwz8oxp 16 2 and and CC cord-332672-fbwz8oxp 16 3 other other JJ cord-332672-fbwz8oxp 16 4 evidences evidence NNS cord-332672-fbwz8oxp 16 5 suggested suggest VBD cord-332672-fbwz8oxp 16 6 that that IN cord-332672-fbwz8oxp 16 7 palm palm NN cord-332672-fbwz8oxp 16 8 civets civet NNS cord-332672-fbwz8oxp 16 9 were be VBD cord-332672-fbwz8oxp 16 10 the the DT cord-332672-fbwz8oxp 16 11 direct direct JJ cord-332672-fbwz8oxp 16 12 source source NN cord-332672-fbwz8oxp 16 13 since since IN cord-332672-fbwz8oxp 16 14 the the DT cord-332672-fbwz8oxp 16 15 isolates isolate NNS cord-332672-fbwz8oxp 16 16 from from IN cord-332672-fbwz8oxp 16 17 civets civet NNS cord-332672-fbwz8oxp 16 18 were be VBD cord-332672-fbwz8oxp 16 19 highly highly RB cord-332672-fbwz8oxp 16 20 related relate VBN cord-332672-fbwz8oxp 16 21 to to IN cord-332672-fbwz8oxp 16 22 human human JJ cord-332672-fbwz8oxp 16 23 isolates isolate NNS cord-332672-fbwz8oxp 16 24 from from IN cord-332672-fbwz8oxp 16 25 2002 2002 CD cord-332672-fbwz8oxp 16 26 -3 -3 CD cord-332672-fbwz8oxp 16 27 and and CC cord-332672-fbwz8oxp 16 28 2003 2003 CD cord-332672-fbwz8oxp 16 29 -4 -4 NNP cord-332672-fbwz8oxp 16 30 SARS SARS NNP cord-332672-fbwz8oxp 16 31 pandemic pandemic NN cord-332672-fbwz8oxp 16 32 ( ( -LRB- cord-332672-fbwz8oxp 16 33 Guan Guan NNP cord-332672-fbwz8oxp 16 34 Y Y NNP cord-332672-fbwz8oxp 16 35 , , , cord-332672-fbwz8oxp 16 36 et et NNP cord-332672-fbwz8oxp 16 37 al al NNP cord-332672-fbwz8oxp 16 38 , , , cord-332672-fbwz8oxp 16 39 2013 2013 CD cord-332672-fbwz8oxp 16 40 Song Song NNP cord-332672-fbwz8oxp 16 41 H h NN cord-332672-fbwz8oxp 16 42 D d NN cord-332672-fbwz8oxp 16 43 , , , cord-332672-fbwz8oxp 16 44 et et NNP cord-332672-fbwz8oxp 16 45 al al NNP cord-332672-fbwz8oxp 16 46 . . NNP cord-332672-fbwz8oxp 16 47 , , , cord-332672-fbwz8oxp 16 48 2005 2005 CD cord-332672-fbwz8oxp 16 49 ; ; : cord-332672-fbwz8oxp 16 50 Wang Wang NNP cord-332672-fbwz8oxp 16 51 M M NNP cord-332672-fbwz8oxp 16 52 , , , cord-332672-fbwz8oxp 16 53 et et NNP cord-332672-fbwz8oxp 16 54 al al NNP cord-332672-fbwz8oxp 16 55 , , , cord-332672-fbwz8oxp 16 56 2005 2005 CD cord-332672-fbwz8oxp 16 57 ) ) -RRB- cord-332672-fbwz8oxp 16 58 . . . cord-332672-fbwz8oxp 17 1 Since since IN cord-332672-fbwz8oxp 17 2 2004 2004 CD cord-332672-fbwz8oxp 17 3 , , , cord-332672-fbwz8oxp 17 4 SL SL NNP cord-332672-fbwz8oxp 17 5 - - HYPH cord-332672-fbwz8oxp 17 6 CoVs CoVs NNP cord-332672-fbwz8oxp 17 7 have have VBP cord-332672-fbwz8oxp 17 8 been be VBN cord-332672-fbwz8oxp 17 9 identified identify VBN cord-332672-fbwz8oxp 17 10 from from IN cord-332672-fbwz8oxp 17 11 bats bat NNS cord-332672-fbwz8oxp 17 12 by by IN cord-332672-fbwz8oxp 17 13 several several JJ cord-332672-fbwz8oxp 17 14 research research NN cord-332672-fbwz8oxp 17 15 groups group NNS cord-332672-fbwz8oxp 17 16 including include VBG cord-332672-fbwz8oxp 17 17 Dr. Dr. NNP cord-332672-fbwz8oxp 17 18 Shi Shi NNP cord-332672-fbwz8oxp 17 19 's 's POS cord-332672-fbwz8oxp 17 20 lab lab NN cord-332672-fbwz8oxp 17 21 Lau Lau NNP cord-332672-fbwz8oxp 17 22 S S NNP cord-332672-fbwz8oxp 17 23 K K NNP cord-332672-fbwz8oxp 17 24 , , , cord-332672-fbwz8oxp 17 25 et et NNP cord-332672-fbwz8oxp 17 26 al al NNP cord-332672-fbwz8oxp 17 27 , , , cord-332672-fbwz8oxp 17 28 2005 2005 CD cord-332672-fbwz8oxp 17 29 ) ) -RRB- cord-332672-fbwz8oxp 17 30 . . . cord-332672-fbwz8oxp 18 1 These these DT cord-332672-fbwz8oxp 18 2 bat bat NN cord-332672-fbwz8oxp 18 3 isolates isolate NNS cord-332672-fbwz8oxp 18 4 are be VBP cord-332672-fbwz8oxp 18 5 more more RBR cord-332672-fbwz8oxp 18 6 genetically genetically RB cord-332672-fbwz8oxp 18 7 diverse diverse JJ cord-332672-fbwz8oxp 18 8 and and CC cord-332672-fbwz8oxp 18 9 share share VBP cord-332672-fbwz8oxp 18 10 an an DT cord-332672-fbwz8oxp 18 11 overall overall JJ cord-332672-fbwz8oxp 18 12 nucleotide nucleotide JJ cord-332672-fbwz8oxp 18 13 identity identity NN cord-332672-fbwz8oxp 18 14 of of IN cord-332672-fbwz8oxp 18 15 88 88 CD cord-332672-fbwz8oxp 18 16 % % NN cord-332672-fbwz8oxp 18 17 to to IN cord-332672-fbwz8oxp 18 18 92 92 CD cord-332672-fbwz8oxp 18 19 % % NN cord-332672-fbwz8oxp 18 20 to to IN cord-332672-fbwz8oxp 18 21 the the DT cord-332672-fbwz8oxp 18 22 SARS SARS NNP cord-332672-fbwz8oxp 18 23 - - HYPH cord-332672-fbwz8oxp 18 24 CoVs CoVs NNP cord-332672-fbwz8oxp 18 25 from from IN cord-332672-fbwz8oxp 18 26 humans human NNS cord-332672-fbwz8oxp 18 27 or or CC cord-332672-fbwz8oxp 18 28 civets civet NNS cord-332672-fbwz8oxp 18 29 , , , cord-332672-fbwz8oxp 18 30 resulting result VBG cord-332672-fbwz8oxp 18 31 in in IN cord-332672-fbwz8oxp 18 32 the the DT cord-332672-fbwz8oxp 18 33 hypothesis hypothesis NN cord-332672-fbwz8oxp 18 34 that that IN cord-332672-fbwz8oxp 18 35 bats bat NNS cord-332672-fbwz8oxp 18 36 may may MD cord-332672-fbwz8oxp 18 37 be be VB cord-332672-fbwz8oxp 18 38 the the DT cord-332672-fbwz8oxp 18 39 natural natural JJ cord-332672-fbwz8oxp 18 40 hosts host NNS cord-332672-fbwz8oxp 18 41 of of IN cord-332672-fbwz8oxp 18 42 SARS SARS NNP cord-332672-fbwz8oxp 18 43 - - HYPH cord-332672-fbwz8oxp 18 44 CoV. CoV. NNP cord-332672-fbwz8oxp 19 1 However however RB cord-332672-fbwz8oxp 19 2 , , , cord-332672-fbwz8oxp 19 3 there there EX cord-332672-fbwz8oxp 19 4 are be VBP cord-332672-fbwz8oxp 19 5 still still RB cord-332672-fbwz8oxp 19 6 some some DT cord-332672-fbwz8oxp 19 7 missing miss VBG cord-332672-fbwz8oxp 19 8 links link NNS cord-332672-fbwz8oxp 19 9 between between IN cord-332672-fbwz8oxp 19 10 previously previously RB cord-332672-fbwz8oxp 19 11 characterized characterize VBN cord-332672-fbwz8oxp 19 12 SL sl NN cord-332672-fbwz8oxp 19 13 - - HYPH cord-332672-fbwz8oxp 19 14 CoVs CoVs NNP cord-332672-fbwz8oxp 19 15 from from IN cord-332672-fbwz8oxp 19 16 bats bat NNS cord-332672-fbwz8oxp 19 17 and and CC cord-332672-fbwz8oxp 19 18 SARS SARS NNP cord-332672-fbwz8oxp 19 19 - - HYPH cord-332672-fbwz8oxp 19 20 CoV CoV NNP cord-332672-fbwz8oxp 19 21 that that WDT cord-332672-fbwz8oxp 19 22 precipitated precipitate VBD cord-332672-fbwz8oxp 19 23 the the DT cord-332672-fbwz8oxp 19 24 2002 2002 CD cord-332672-fbwz8oxp 19 25 - - SYM cord-332672-fbwz8oxp 19 26 3 3 CD cord-332672-fbwz8oxp 19 27 outbreaks outbreak NNS cord-332672-fbwz8oxp 19 28 . . . cord-332672-fbwz8oxp 20 1 1 1 LS cord-332672-fbwz8oxp 20 2 ) ) -RRB- cord-332672-fbwz8oxp 21 1 albeit albeit IN cord-332672-fbwz8oxp 21 2 the the DT cord-332672-fbwz8oxp 21 3 overall overall JJ cord-332672-fbwz8oxp 21 4 genome genome NN cord-332672-fbwz8oxp 21 5 sequence sequence NN cord-332672-fbwz8oxp 21 6 similarity similarity NN cord-332672-fbwz8oxp 21 7 , , , cord-332672-fbwz8oxp 21 8 there there EX cord-332672-fbwz8oxp 21 9 are be VBP cord-332672-fbwz8oxp 21 10 significant significant JJ cord-332672-fbwz8oxp 21 11 differences difference NNS cord-332672-fbwz8oxp 21 12 in in IN cord-332672-fbwz8oxp 21 13 spike spike NN cord-332672-fbwz8oxp 21 14 ( ( -LRB- cord-332672-fbwz8oxp 21 15 S s NN cord-332672-fbwz8oxp 21 16 ) ) -RRB- cord-332672-fbwz8oxp 21 17 protein protein NN cord-332672-fbwz8oxp 21 18 between between IN cord-332672-fbwz8oxp 21 19 the the DT cord-332672-fbwz8oxp 21 20 previously previously RB cord-332672-fbwz8oxp 21 21 known know VBN cord-332672-fbwz8oxp 21 22 SL sl NN cord-332672-fbwz8oxp 21 23 - - HYPH cord-332672-fbwz8oxp 21 24 CoVs CoVs NNP cord-332672-fbwz8oxp 21 25 and and CC cord-332672-fbwz8oxp 21 26 SARS SARS NNP cord-332672-fbwz8oxp 21 27 - - HYPH cord-332672-fbwz8oxp 21 28 CoVs CoVs NNP cord-332672-fbwz8oxp 21 29 . . . cord-332672-fbwz8oxp 22 1 The the DT cord-332672-fbwz8oxp 22 2 sequence sequence NN cord-332672-fbwz8oxp 22 3 identity identity NN cord-332672-fbwz8oxp 22 4 of of IN cord-332672-fbwz8oxp 22 5 S1 s1 NN cord-332672-fbwz8oxp 22 6 fell fall VBD cord-332672-fbwz8oxp 22 7 to to IN cord-332672-fbwz8oxp 22 8 64 64 CD cord-332672-fbwz8oxp 22 9 % % NN cord-332672-fbwz8oxp 22 10 , , , cord-332672-fbwz8oxp 22 11 accompanying accompany VBG cord-332672-fbwz8oxp 22 12 with with IN cord-332672-fbwz8oxp 22 13 insertions insertion NNS cord-332672-fbwz8oxp 22 14 and and CC cord-332672-fbwz8oxp 22 15 ( ( -LRB- cord-332672-fbwz8oxp 22 16 or or CC cord-332672-fbwz8oxp 22 17 ) ) -RRB- cord-332672-fbwz8oxp 22 18 mutations mutation NNS cord-332672-fbwz8oxp 22 19 in in IN cord-332672-fbwz8oxp 22 20 this this DT cord-332672-fbwz8oxp 22 21 region region NN cord-332672-fbwz8oxp 22 22 . . . cord-332672-fbwz8oxp 23 1 S1 s1 NN cord-332672-fbwz8oxp 23 2 contains contain VBZ cord-332672-fbwz8oxp 23 3 the the DT cord-332672-fbwz8oxp 23 4 receptor receptor NN cord-332672-fbwz8oxp 23 5 binding bind VBG cord-332672-fbwz8oxp 23 6 domain domain NN cord-332672-fbwz8oxp 23 7 ( ( -LRB- cord-332672-fbwz8oxp 23 8 RBD RBD NNP cord-332672-fbwz8oxp 23 9 ) ) -RRB- cord-332672-fbwz8oxp 23 10 , , , cord-332672-fbwz8oxp 23 11 which which WDT cord-332672-fbwz8oxp 23 12 plays play VBZ cord-332672-fbwz8oxp 23 13 a a DT cord-332672-fbwz8oxp 23 14 key key JJ cord-332672-fbwz8oxp 23 15 role role NN cord-332672-fbwz8oxp 23 16 in in IN cord-332672-fbwz8oxp 23 17 receptor receptor NN cord-332672-fbwz8oxp 23 18 recognition recognition NN cord-332672-fbwz8oxp 23 19 and and CC cord-332672-fbwz8oxp 23 20 is be VBZ cord-332672-fbwz8oxp 23 21 a a DT cord-332672-fbwz8oxp 23 22 major major JJ cord-332672-fbwz8oxp 23 23 determinant determinant NN cord-332672-fbwz8oxp 23 24 of of IN cord-332672-fbwz8oxp 23 25 host host NN cord-332672-fbwz8oxp 23 26 range range NN cord-332672-fbwz8oxp 23 27 and and CC cord-332672-fbwz8oxp 23 28 cross cross NN cord-332672-fbwz8oxp 23 29 - - JJ cord-332672-fbwz8oxp 23 30 species species JJ cord-332672-fbwz8oxp 23 31 infection infection NN cord-332672-fbwz8oxp 23 32 of of IN cord-332672-fbwz8oxp 23 33 SARS- sars- NN cord-332672-fbwz8oxp 24 1 CoV. CoV. NNP cord-332672-fbwz8oxp 25 1 It -PRON- PRP cord-332672-fbwz8oxp 25 2 was be VBD cord-332672-fbwz8oxp 25 3 suggested suggest VBN cord-332672-fbwz8oxp 25 4 that that IN cord-332672-fbwz8oxp 25 5 the the DT cord-332672-fbwz8oxp 25 6 previously previously RB cord-332672-fbwz8oxp 25 7 known know VBN cord-332672-fbwz8oxp 25 8 bat bat NN cord-332672-fbwz8oxp 25 9 SL sl NN cord-332672-fbwz8oxp 25 10 - - HYPH cord-332672-fbwz8oxp 25 11 CoV cov NN cord-332672-fbwz8oxp 25 12 stains stain NNS cord-332672-fbwz8oxp 25 13 can can MD cord-332672-fbwz8oxp 25 14 not not RB cord-332672-fbwz8oxp 25 15 jump jump VB cord-332672-fbwz8oxp 25 16 from from IN cord-332672-fbwz8oxp 25 17 bats bat NNS cord-332672-fbwz8oxp 25 18 to to IN cord-332672-fbwz8oxp 25 19 civets civet NNS cord-332672-fbwz8oxp 25 20 or or CC cord-332672-fbwz8oxp 25 21 humans human NNS cord-332672-fbwz8oxp 25 22 owing owe VBG cord-332672-fbwz8oxp 25 23 to to IN cord-332672-fbwz8oxp 25 24 the the DT cord-332672-fbwz8oxp 25 25 significant significant JJ cord-332672-fbwz8oxp 25 26 differences difference NNS cord-332672-fbwz8oxp 25 27 between between IN cord-332672-fbwz8oxp 25 28 their -PRON- PRP$ cord-332672-fbwz8oxp 25 29 RBDs rbd NNS cord-332672-fbwz8oxp 25 30 ( ( -LRB- cord-332672-fbwz8oxp 25 31 Li Li NNP cord-332672-fbwz8oxp 25 32 F F NNP cord-332672-fbwz8oxp 25 33 , , , cord-332672-fbwz8oxp 25 34 2013 2013 CD cord-332672-fbwz8oxp 25 35 ) ) -RRB- cord-332672-fbwz8oxp 25 36 ; ; : cord-332672-fbwz8oxp 25 37 2 2 LS cord-332672-fbwz8oxp 25 38 ) ) -RRB- cord-332672-fbwz8oxp 25 39 although although IN cord-332672-fbwz8oxp 25 40 SL SL NNP cord-332672-fbwz8oxp 25 41 - - HYPH cord-332672-fbwz8oxp 25 42 CoVs CoVs NNP cord-332672-fbwz8oxp 25 43 have have VBP cord-332672-fbwz8oxp 25 44 been be VBN cord-332672-fbwz8oxp 25 45 identified identify VBN cord-332672-fbwz8oxp 25 46 from from IN cord-332672-fbwz8oxp 25 47 different different JJ cord-332672-fbwz8oxp 25 48 bat bat NN cord-332672-fbwz8oxp 25 49 species specie NNS cord-332672-fbwz8oxp 25 50 , , , cord-332672-fbwz8oxp 25 51 isolation isolation NN cord-332672-fbwz8oxp 25 52 of of IN cord-332672-fbwz8oxp 25 53 a a DT cord-332672-fbwz8oxp 25 54 live live JJ cord-332672-fbwz8oxp 25 55 SL sl NN cord-332672-fbwz8oxp 25 56 - - HYPH cord-332672-fbwz8oxp 25 57 CoVs CoVs NNP cord-332672-fbwz8oxp 25 58 from from IN cord-332672-fbwz8oxp 25 59 bats bat NNS cord-332672-fbwz8oxp 25 60 never never RB cord-332672-fbwz8oxp 25 61 succeed succeed VBP cord-332672-fbwz8oxp 25 62 ; ; : cord-332672-fbwz8oxp 25 63 3 3 LS cord-332672-fbwz8oxp 25 64 ) ) -RRB- cord-332672-fbwz8oxp 26 1 no no DT cord-332672-fbwz8oxp 26 2 native native JJ cord-332672-fbwz8oxp 26 3 SL sl NN cord-332672-fbwz8oxp 26 4 - - HYPH cord-332672-fbwz8oxp 26 5 CoV CoV NNP cord-332672-fbwz8oxp 26 6 from from IN cord-332672-fbwz8oxp 26 7 bats bat NNS cord-332672-fbwz8oxp 26 8 could could MD cord-332672-fbwz8oxp 26 9 use use VB cord-332672-fbwz8oxp 26 10 ACE2 ACE2 NNP cord-332672-fbwz8oxp 26 11 as as IN cord-332672-fbwz8oxp 26 12 receptors receptor NNS cord-332672-fbwz8oxp 26 13 and and CC cord-332672-fbwz8oxp 26 14 infect infect VB cord-332672-fbwz8oxp 26 15 human human JJ cord-332672-fbwz8oxp 26 16 cells cell NNS cord-332672-fbwz8oxp 26 17 , , , cord-332672-fbwz8oxp 26 18 only only RB cord-332672-fbwz8oxp 26 19 when when WRB cord-332672-fbwz8oxp 26 20 its -PRON- PRP$ cord-332672-fbwz8oxp 26 21 RBD RBD NNP cord-332672-fbwz8oxp 26 22 is be VBZ cord-332672-fbwz8oxp 26 23 replaced replace VBN cord-332672-fbwz8oxp 26 24 with with IN cord-332672-fbwz8oxp 26 25 the the DT cord-332672-fbwz8oxp 26 26 counterpart counterpart NN cord-332672-fbwz8oxp 26 27 from from IN cord-332672-fbwz8oxp 26 28 a a DT cord-332672-fbwz8oxp 26 29 human human JJ cord-332672-fbwz8oxp 26 30 SARS SARS NNP cord-332672-fbwz8oxp 26 31 - - HYPH cord-332672-fbwz8oxp 26 32 CoV CoV NNP cord-332672-fbwz8oxp 26 33 strain strain NN cord-332672-fbwz8oxp 26 34 ( ( -LRB- cord-332672-fbwz8oxp 26 35 Li Li NNP cord-332672-fbwz8oxp 26 36 W W NNP cord-332672-fbwz8oxp 26 37 , , , cord-332672-fbwz8oxp 26 38 et et NNP cord-332672-fbwz8oxp 26 39 al al NNP cord-332672-fbwz8oxp 26 40 , , , cord-332672-fbwz8oxp 26 41 2003 2003 CD cord-332672-fbwz8oxp 26 42 ; ; : cord-332672-fbwz8oxp 26 43 Becker Becker NNP cord-332672-fbwz8oxp 26 44 M M NNP cord-332672-fbwz8oxp 26 45 M M NNP cord-332672-fbwz8oxp 26 46 , , , cord-332672-fbwz8oxp 26 47 et et NNP cord-332672-fbwz8oxp 26 48 al al NNP cord-332672-fbwz8oxp 26 49 , , , cord-332672-fbwz8oxp 26 50 2008 2008 CD cord-332672-fbwz8oxp 26 51 ; ; : cord-332672-fbwz8oxp 26 52 Ren Ren NNP cord-332672-fbwz8oxp 26 53 W W NNP cord-332672-fbwz8oxp 26 54 , , , cord-332672-fbwz8oxp 26 55 et et NNP cord-332672-fbwz8oxp 26 56 al al NNP cord-332672-fbwz8oxp 26 57 , , , cord-332672-fbwz8oxp 26 58 2008 2008 CD cord-332672-fbwz8oxp 26 59 ) ) -RRB- cord-332672-fbwz8oxp 26 60 . . . cord-332672-fbwz8oxp 27 1 Therefore therefore RB cord-332672-fbwz8oxp 27 2 , , , cord-332672-fbwz8oxp 27 3 these these DT cord-332672-fbwz8oxp 27 4 SL sl NN cord-332672-fbwz8oxp 27 5 - - HYPH cord-332672-fbwz8oxp 27 6 CoVs CoVs NNP cord-332672-fbwz8oxp 27 7 seem seem VBP cord-332672-fbwz8oxp 27 8 unlikely unlikely JJ cord-332672-fbwz8oxp 27 9 to to TO cord-332672-fbwz8oxp 27 10 be be VB cord-332672-fbwz8oxp 27 11 the the DT cord-332672-fbwz8oxp 27 12 immediate immediate JJ cord-332672-fbwz8oxp 27 13 precursors precursor NNS cord-332672-fbwz8oxp 27 14 of of IN cord-332672-fbwz8oxp 27 15 civet civet NN cord-332672-fbwz8oxp 27 16 or or CC cord-332672-fbwz8oxp 27 17 human human JJ cord-332672-fbwz8oxp 27 18 SARS SARS NNP cord-332672-fbwz8oxp 27 19 - - HYPH cord-332672-fbwz8oxp 27 20 CoVs CoVs NNP cord-332672-fbwz8oxp 27 21 ( ( -LRB- cord-332672-fbwz8oxp 27 22 Li Li NNP cord-332672-fbwz8oxp 27 23 F F NNP cord-332672-fbwz8oxp 27 24 , , , cord-332672-fbwz8oxp 27 25 2013 2013 CD cord-332672-fbwz8oxp 27 26 ) ) -RRB- cord-332672-fbwz8oxp 27 27 . . . cord-332672-fbwz8oxp 28 1 After after IN cord-332672-fbwz8oxp 28 2 10 10 CD cord-332672-fbwz8oxp 28 3 years year NNS cord-332672-fbwz8oxp 28 4 virus virus NN cord-332672-fbwz8oxp 28 5 hunting hunting NN cord-332672-fbwz8oxp 28 6 , , , cord-332672-fbwz8oxp 28 7 Ge Ge NNP cord-332672-fbwz8oxp 28 8 et et NNP cord-332672-fbwz8oxp 28 9 al al NNP cord-332672-fbwz8oxp 28 10 . . NNP cord-332672-fbwz8oxp 28 11 are be VBP cord-332672-fbwz8oxp 28 12 now now RB cord-332672-fbwz8oxp 28 13 able able JJ cord-332672-fbwz8oxp 28 14 to to TO cord-332672-fbwz8oxp 28 15 fill fill VB cord-332672-fbwz8oxp 28 16 in in RP cord-332672-fbwz8oxp 28 17 important important JJ cord-332672-fbwz8oxp 28 18 316 316 CD cord-332672-fbwz8oxp 28 19 missing miss VBG cord-332672-fbwz8oxp 28 20 links link NNS cord-332672-fbwz8oxp 28 21 associated associate VBN cord-332672-fbwz8oxp 28 22 with with IN cord-332672-fbwz8oxp 28 23 SARS SARS NNP cord-332672-fbwz8oxp 28 24 origin origin NN cord-332672-fbwz8oxp 28 25 and and CC cord-332672-fbwz8oxp 28 26 epidemic epidemic NN cord-332672-fbwz8oxp 28 27 ( ( -LRB- cord-332672-fbwz8oxp 28 28 Fig Fig NNP cord-332672-fbwz8oxp 28 29 . . . cord-332672-fbwz8oxp 28 30 1 1 CD cord-332672-fbwz8oxp 28 31 ) ) -RRB- cord-332672-fbwz8oxp 28 32 . . . cord-332672-fbwz8oxp 29 1 Firstly firstly RB cord-332672-fbwz8oxp 29 2 , , , cord-332672-fbwz8oxp 29 3 they -PRON- PRP cord-332672-fbwz8oxp 29 4 identified identify VBD cord-332672-fbwz8oxp 29 5 two two CD cord-332672-fbwz8oxp 29 6 novel novel JJ cord-332672-fbwz8oxp 29 7 SL sl NN cord-332672-fbwz8oxp 29 8 - - HYPH cord-332672-fbwz8oxp 29 9 CoV cov NN cord-332672-fbwz8oxp 29 10 stains stain NNS cord-332672-fbwz8oxp 29 11 RsSHC014 RsSHC014 NNPS cord-332672-fbwz8oxp 29 12 and and CC cord-332672-fbwz8oxp 29 13 RS3367 rs3367 NN cord-332672-fbwz8oxp 29 14 in in IN cord-332672-fbwz8oxp 29 15 Chinese chinese JJ cord-332672-fbwz8oxp 29 16 horseshoe horseshoe NN cord-332672-fbwz8oxp 29 17 bats bat NNS cord-332672-fbwz8oxp 29 18 , , , cord-332672-fbwz8oxp 29 19 which which WDT cord-332672-fbwz8oxp 29 20 show show VBP cord-332672-fbwz8oxp 29 21 higher high JJR cord-332672-fbwz8oxp 29 22 sequence sequence NN cord-332672-fbwz8oxp 29 23 similarity similarity NN cord-332672-fbwz8oxp 29 24 ( ( -LRB- cord-332672-fbwz8oxp 29 25 ~95 ~95 CD cord-332672-fbwz8oxp 29 26 % % NN cord-332672-fbwz8oxp 29 27 identity identity NN cord-332672-fbwz8oxp 29 28 ) ) -RRB- cord-332672-fbwz8oxp 29 29 with with IN cord-332672-fbwz8oxp 29 30 human human JJ cord-332672-fbwz8oxp 29 31 SARS SARS NNP cord-332672-fbwz8oxp 29 32 - - HYPH cord-332672-fbwz8oxp 29 33 CoV CoV NNP cord-332672-fbwz8oxp 29 34 than than IN cord-332672-fbwz8oxp 29 35 observed observe VBD cord-332672-fbwz8oxp 29 36 previously previously RB cord-332672-fbwz8oxp 30 1 ( ( -LRB- cord-332672-fbwz8oxp 30 2 Lau Lau NNP cord-332672-fbwz8oxp 30 3 S S NNP cord-332672-fbwz8oxp 30 4 K K NNP cord-332672-fbwz8oxp 30 5 , , , cord-332672-fbwz8oxp 30 6 et et NNP cord-332672-fbwz8oxp 30 7 al al NNP cord-332672-fbwz8oxp 30 8 , , , cord-332672-fbwz8oxp 30 9 2005 2005 CD cord-332672-fbwz8oxp 30 10 ; ; : cord-332672-fbwz8oxp 30 11 Li Li NNP cord-332672-fbwz8oxp 30 12 F F NNP cord-332672-fbwz8oxp 30 13 , , , cord-332672-fbwz8oxp 30 14 2013 2013 CD cord-332672-fbwz8oxp 30 15 ; ; : cord-332672-fbwz8oxp 30 16 Ren Ren NNP cord-332672-fbwz8oxp 30 17 W W NNP cord-332672-fbwz8oxp 30 18 , , , cord-332672-fbwz8oxp 30 19 et et NNP cord-332672-fbwz8oxp 30 20 al al NNP cord-332672-fbwz8oxp 30 21 , , , cord-332672-fbwz8oxp 30 22 2006 2006 CD cord-332672-fbwz8oxp 30 23 ; ; : cord-332672-fbwz8oxp 30 24 Tong Tong NNP cord-332672-fbwz8oxp 30 25 S S NNP cord-332672-fbwz8oxp 30 26 , , , cord-332672-fbwz8oxp 30 27 et et NNP cord-332672-fbwz8oxp 30 28 al al NNP cord-332672-fbwz8oxp 30 29 , , , cord-332672-fbwz8oxp 30 30 2009 2009 CD cord-332672-fbwz8oxp 30 31 ) ) -RRB- cord-332672-fbwz8oxp 30 32 . . . cord-332672-fbwz8oxp 31 1 Particularly particularly RB cord-332672-fbwz8oxp 31 2 , , , cord-332672-fbwz8oxp 31 3 their -PRON- PRP$ cord-332672-fbwz8oxp 31 4 RBDs rbd NNS cord-332672-fbwz8oxp 31 5 are be VBP cord-332672-fbwz8oxp 31 6 more more RBR cord-332672-fbwz8oxp 31 7 closely closely RB cord-332672-fbwz8oxp 31 8 related related JJ cord-332672-fbwz8oxp 31 9 to to IN cord-332672-fbwz8oxp 31 10 ( ( -LRB- cord-332672-fbwz8oxp 31 11 85 85 CD cord-332672-fbwz8oxp 31 12 % % NN cord-332672-fbwz8oxp 31 13 aa aa NN cord-332672-fbwz8oxp 31 14 identity identity NN cord-332672-fbwz8oxp 31 15 for for IN cord-332672-fbwz8oxp 31 16 RsSHC014 RsSHC014 NNS cord-332672-fbwz8oxp 31 17 and and CC cord-332672-fbwz8oxp 31 18 96 96 CD cord-332672-fbwz8oxp 31 19 % % NN cord-332672-fbwz8oxp 31 20 for for IN cord-332672-fbwz8oxp 31 21 RS3367 rs3367 NN cord-332672-fbwz8oxp 31 22 ) ) -RRB- cord-332672-fbwz8oxp 32 1 SARS SARS NNP cord-332672-fbwz8oxp 32 2 - - HYPH cord-332672-fbwz8oxp 32 3 CoV cov NN cord-332672-fbwz8oxp 32 4 RBD RBD NNP cord-332672-fbwz8oxp 32 5 , , , cord-332672-fbwz8oxp 32 6 with with IN cord-332672-fbwz8oxp 32 7 perfect perfect JJ cord-332672-fbwz8oxp 32 8 sequence sequence NN cord-332672-fbwz8oxp 32 9 alignment alignment NN cord-332672-fbwz8oxp 32 10 and and CC cord-332672-fbwz8oxp 32 11 absence absence NN cord-332672-fbwz8oxp 32 12 of of IN cord-332672-fbwz8oxp 32 13 any any DT cord-332672-fbwz8oxp 32 14 deletion deletion NN cord-332672-fbwz8oxp 32 15 or or CC cord-332672-fbwz8oxp 32 16 insertion insertion NN cord-332672-fbwz8oxp 32 17 . . . cord-332672-fbwz8oxp 33 1 Secondly secondly RB cord-332672-fbwz8oxp 33 2 , , , cord-332672-fbwz8oxp 33 3 they -PRON- PRP cord-332672-fbwz8oxp 33 4 reported report VBD cord-332672-fbwz8oxp 33 5 the the DT cord-332672-fbwz8oxp 33 6 first first JJ cord-332672-fbwz8oxp 33 7 isolation isolation NN cord-332672-fbwz8oxp 33 8 of of IN cord-332672-fbwz8oxp 33 9 a a DT cord-332672-fbwz8oxp 33 10 live live JJ cord-332672-fbwz8oxp 33 11 bat bat NN cord-332672-fbwz8oxp 33 12 SL sl NN cord-332672-fbwz8oxp 33 13 - - HYPH cord-332672-fbwz8oxp 33 14 CoV cov NN cord-332672-fbwz8oxp 33 15 strain strain NN cord-332672-fbwz8oxp 33 16 ( ( -LRB- cord-332672-fbwz8oxp 33 17 SL SL NNP cord-332672-fbwz8oxp 33 18 - - HYPH cord-332672-fbwz8oxp 33 19 CoV CoV NNP cord-332672-fbwz8oxp 33 20 - - HYPH cord-332672-fbwz8oxp 33 21 WIV1 WIV1 NNP cord-332672-fbwz8oxp 33 22 ) ) -RRB- cord-332672-fbwz8oxp 33 23 with with IN cord-332672-fbwz8oxp 33 24 Vero Vero NNP cord-332672-fbwz8oxp 33 25 E6 E6 NNP cord-332672-fbwz8oxp 33 26 cells cell NNS cord-332672-fbwz8oxp 33 27 . . . cord-332672-fbwz8oxp 34 1 This this DT cord-332672-fbwz8oxp 34 2 isolate isolate NN cord-332672-fbwz8oxp 34 3 is be VBZ cord-332672-fbwz8oxp 34 4 almost almost RB cord-332672-fbwz8oxp 34 5 identical identical JJ cord-332672-fbwz8oxp 34 6 to to IN cord-332672-fbwz8oxp 34 7 its -PRON- PRP$ cord-332672-fbwz8oxp 34 8 parental parental JJ cord-332672-fbwz8oxp 34 9 virus virus NN cord-332672-fbwz8oxp 34 10 Rs3367 Rs3367 NNP cord-332672-fbwz8oxp 34 11 , , , cord-332672-fbwz8oxp 34 12 with with IN cord-332672-fbwz8oxp 34 13 99 99 CD cord-332672-fbwz8oxp 34 14 % % NN cord-332672-fbwz8oxp 34 15 nt nt JJ cord-332672-fbwz8oxp 34 16 identity identity NN cord-332672-fbwz8oxp 34 17 and and CC cord-332672-fbwz8oxp 34 18 100 100 CD cord-332672-fbwz8oxp 34 19 % % NN cord-332672-fbwz8oxp 34 20 aa aa NNP cord-332672-fbwz8oxp 34 21 identity identity NN cord-332672-fbwz8oxp 34 22 even even RB cord-332672-fbwz8oxp 34 23 in in IN cord-332672-fbwz8oxp 34 24 the the DT cord-332672-fbwz8oxp 34 25 highly highly RB cord-332672-fbwz8oxp 34 26 variable variable JJ cord-332672-fbwz8oxp 34 27 S1 s1 NN cord-332672-fbwz8oxp 34 28 region region NN cord-332672-fbwz8oxp 34 29 . . . cord-332672-fbwz8oxp 35 1 Thirdly thirdly RB cord-332672-fbwz8oxp 35 2 , , , cord-332672-fbwz8oxp 35 3 by by IN cord-332672-fbwz8oxp 35 4 using use VBG cord-332672-fbwz8oxp 35 5 this this DT cord-332672-fbwz8oxp 35 6 valuable valuable JJ cord-332672-fbwz8oxp 35 7 isolate isolate NN cord-332672-fbwz8oxp 35 8 WIV1 WIV1 NNP cord-332672-fbwz8oxp 35 9 , , , cord-332672-fbwz8oxp 35 10 Ge Ge NNP cord-332672-fbwz8oxp 35 11 et et NNP cord-332672-fbwz8oxp 35 12 al al NNP cord-332672-fbwz8oxp 35 13 . . NNP cord-332672-fbwz8oxp 35 14 demonstrated demonstrate VBD cord-332672-fbwz8oxp 35 15 for for IN cord-332672-fbwz8oxp 35 16 the the DT cord-332672-fbwz8oxp 35 17 first first JJ cord-332672-fbwz8oxp 35 18 time time NN cord-332672-fbwz8oxp 35 19 that that IN cord-332672-fbwz8oxp 35 20 a a DT cord-332672-fbwz8oxp 35 21 bat bat NN cord-332672-fbwz8oxp 35 22 SL sl NN cord-332672-fbwz8oxp 35 23 - - HYPH cord-332672-fbwz8oxp 35 24 CoV cov NN cord-332672-fbwz8oxp 35 25 strain strain NN cord-332672-fbwz8oxp 35 26 can can MD cord-332672-fbwz8oxp 35 27 exploit exploit VB cord-332672-fbwz8oxp 35 28 human- human- NN cord-332672-fbwz8oxp 35 29 , , , cord-332672-fbwz8oxp 35 30 civet civet NN cord-332672-fbwz8oxp 35 31 - - HYPH cord-332672-fbwz8oxp 35 32 and and CC cord-332672-fbwz8oxp 35 33 bat bat NN cord-332672-fbwz8oxp 35 34 - - HYPH cord-332672-fbwz8oxp 35 35 derived derive VBN cord-332672-fbwz8oxp 35 36 ACE2 ACE2 NNP cord-332672-fbwz8oxp 35 37 as as IN cord-332672-fbwz8oxp 35 38 its -PRON- PRP$ cord-332672-fbwz8oxp 35 39 cellular cellular JJ cord-332672-fbwz8oxp 35 40 entry entry NN cord-332672-fbwz8oxp 35 41 receptors receptor NNS cord-332672-fbwz8oxp 35 42 and and CC cord-332672-fbwz8oxp 35 43 replicated replicate VBD cord-332672-fbwz8oxp 35 44 efficiently efficiently RB cord-332672-fbwz8oxp 35 45 in in IN cord-332672-fbwz8oxp 35 46 HeLa HeLa NNP cord-332672-fbwz8oxp 35 47 cells cell NNS cord-332672-fbwz8oxp 35 48 which which WDT cord-332672-fbwz8oxp 35 49 express express VBP cord-332672-fbwz8oxp 35 50 these these DT cord-332672-fbwz8oxp 35 51 receptors receptor NNS cord-332672-fbwz8oxp 35 52 . . . cord-332672-fbwz8oxp 36 1 They -PRON- PRP cord-332672-fbwz8oxp 36 2 further further RB cord-332672-fbwz8oxp 36 3 assessed assess VBD cord-332672-fbwz8oxp 36 4 the the DT cord-332672-fbwz8oxp 36 5 host host NN cord-332672-fbwz8oxp 36 6 ranges range NNS cord-332672-fbwz8oxp 36 7 of of IN cord-332672-fbwz8oxp 36 8 WIV1 WIV1 NNP cord-332672-fbwz8oxp 36 9 with with IN cord-332672-fbwz8oxp 36 10 a a DT cord-332672-fbwz8oxp 36 11 variety variety NN cord-332672-fbwz8oxp 36 12 of of IN cord-332672-fbwz8oxp 36 13 cell cell NN cord-332672-fbwz8oxp 36 14 lines line NNS cord-332672-fbwz8oxp 36 15 and and CC cord-332672-fbwz8oxp 36 16 found find VBD cord-332672-fbwz8oxp 36 17 that that IN cord-332672-fbwz8oxp 36 18 cells cell NNS cord-332672-fbwz8oxp 36 19 from from IN cord-332672-fbwz8oxp 36 20 different different JJ cord-332672-fbwz8oxp 36 21 species specie NNS cord-332672-fbwz8oxp 36 22 ( ( -LRB- cord-332672-fbwz8oxp 36 23 human human NN cord-332672-fbwz8oxp 36 24 , , , cord-332672-fbwz8oxp 36 25 pig pig NN cord-332672-fbwz8oxp 36 26 , , , cord-332672-fbwz8oxp 36 27 and and CC cord-332672-fbwz8oxp 36 28 bat bat NN cord-332672-fbwz8oxp 36 29 ) ) -RRB- cord-332672-fbwz8oxp 36 30 are be VBP cord-332672-fbwz8oxp 36 31 able able JJ cord-332672-fbwz8oxp 36 32 to to TO cord-332672-fbwz8oxp 36 33 support support VB cord-332672-fbwz8oxp 36 34 the the DT cord-332672-fbwz8oxp 36 35 virus virus NN cord-332672-fbwz8oxp 36 36 replication replication NN cord-332672-fbwz8oxp 36 37 at at IN cord-332672-fbwz8oxp 36 38 different different JJ cord-332672-fbwz8oxp 36 39 levels level NNS cord-332672-fbwz8oxp 36 40 . . . cord-332672-fbwz8oxp 37 1 In in IN cord-332672-fbwz8oxp 37 2 addition addition NN cord-332672-fbwz8oxp 37 3 , , , cord-332672-fbwz8oxp 37 4 WIV1 WIV1 NNP cord-332672-fbwz8oxp 37 5 can can MD cord-332672-fbwz8oxp 37 6 be be VB cord-332672-fbwz8oxp 37 7 neutralized neutralize VBN cord-332672-fbwz8oxp 37 8 by by IN cord-332672-fbwz8oxp 37 9 different different JJ cord-332672-fbwz8oxp 37 10 SARSpatient SARSpatient NNP cord-332672-fbwz8oxp 37 11 sera sera NNP cord-332672-fbwz8oxp 37 12 collected collect VBN cord-332672-fbwz8oxp 37 13 in in IN cord-332672-fbwz8oxp 37 14 2003 2003 CD cord-332672-fbwz8oxp 37 15 . . . cord-332672-fbwz8oxp 38 1 These these DT cord-332672-fbwz8oxp 38 2 findings finding NNS cord-332672-fbwz8oxp 38 3 suggested suggest VBD cord-332672-fbwz8oxp 38 4 a a DT cord-332672-fbwz8oxp 38 5 much much RB cord-332672-fbwz8oxp 38 6 closer close JJR cord-332672-fbwz8oxp 38 7 relationship relationship NN cord-332672-fbwz8oxp 38 8 between between IN cord-332672-fbwz8oxp 38 9 bat bat NN cord-332672-fbwz8oxp 38 10 WIV1 WIV1 NNP cord-332672-fbwz8oxp 38 11 strain strain NN cord-332672-fbwz8oxp 38 12 and and CC cord-332672-fbwz8oxp 38 13 SARS SARS NNP cord-332672-fbwz8oxp 38 14 - - HYPH cord-332672-fbwz8oxp 38 15 CoV. CoV. NNP cord-332672-fbwz8oxp 39 1 Interestingly interestingly RB cord-332672-fbwz8oxp 39 2 , , , cord-332672-fbwz8oxp 39 3 although although IN cord-332672-fbwz8oxp 39 4 not not RB cord-332672-fbwz8oxp 39 5 being be VBG cord-332672-fbwz8oxp 39 6 further further RB cord-332672-fbwz8oxp 39 7 discussed discuss VBN cord-332672-fbwz8oxp 39 8 in in IN cord-332672-fbwz8oxp 39 9 their -PRON- PRP$ cord-332672-fbwz8oxp 39 10 publication publication NN cord-332672-fbwz8oxp 39 11 , , , cord-332672-fbwz8oxp 39 12 one one CD cord-332672-fbwz8oxp 39 13 of of IN cord-332672-fbwz8oxp 39 14 the the DT cord-332672-fbwz8oxp 39 15 five five CD cord-332672-fbwz8oxp 39 16 key key JJ cord-332672-fbwz8oxp 39 17 residues residue NNS cord-332672-fbwz8oxp 39 18 in in IN cord-332672-fbwz8oxp 39 19 RBD RBD NNP cord-332672-fbwz8oxp 39 20 , , , cord-332672-fbwz8oxp 39 21 the the DT cord-332672-fbwz8oxp 39 22 479 479 CD cord-332672-fbwz8oxp 39 23 aa aa NNP cord-332672-fbwz8oxp 39 24 , , , cord-332672-fbwz8oxp 39 25 is be VBZ cord-332672-fbwz8oxp 39 26 an an DT cord-332672-fbwz8oxp 39 27 asparagine asparagine NN cord-332672-fbwz8oxp 39 28 in in IN cord-332672-fbwz8oxp 39 29 the the DT cord-332672-fbwz8oxp 39 30 RS3367 rs3367 NN cord-332672-fbwz8oxp 39 31 . . . cord-332672-fbwz8oxp 40 1 The the DT cord-332672-fbwz8oxp 40 2 residue residue NN cord-332672-fbwz8oxp 40 3 479 479 CD cord-332672-fbwz8oxp 40 4 is be VBZ cord-332672-fbwz8oxp 40 5 known know VBN cord-332672-fbwz8oxp 40 6 to to TO cord-332672-fbwz8oxp 40 7 be be VB cord-332672-fbwz8oxp 40 8 an an DT cord-332672-fbwz8oxp 40 9 asparagine asparagine NN cord-332672-fbwz8oxp 40 10 only only RB cord-332672-fbwz8oxp 40 11 in in IN cord-332672-fbwz8oxp 40 12 human human JJ cord-332672-fbwz8oxp 40 13 SAR SAR NNP cord-332672-fbwz8oxp 40 14 - - HYPH cord-332672-fbwz8oxp 40 15 CoVs CoVs NNP cord-332672-fbwz8oxp 40 16 , , , cord-332672-fbwz8oxp 40 17 but but CC cord-332672-fbwz8oxp 40 18 not not RB cord-332672-fbwz8oxp 40 19 in in IN cord-332672-fbwz8oxp 40 20 the the DT cord-332672-fbwz8oxp 40 21 previously previously RB cord-332672-fbwz8oxp 40 22 identified identify VBN cord-332672-fbwz8oxp 40 23 bat bat NN cord-332672-fbwz8oxp 40 24 SL sl NN cord-332672-fbwz8oxp 40 25 - - HYPH cord-332672-fbwz8oxp 40 26 CoVs CoVs NNP cord-332672-fbwz8oxp 40 27 or or CC cord-332672-fbwz8oxp 40 28 civet civet NN cord-332672-fbwz8oxp 40 29 SAR SAR NNP cord-332672-fbwz8oxp 40 30 - - HYPH cord-332672-fbwz8oxp 40 31 CoVs CoVs NNP cord-332672-fbwz8oxp 40 32 . . . cord-332672-fbwz8oxp 41 1 It -PRON- PRP cord-332672-fbwz8oxp 41 2 is be VBZ cord-332672-fbwz8oxp 41 3 proposed propose VBN cord-332672-fbwz8oxp 41 4 that that IN cord-332672-fbwz8oxp 41 5 an an DT cord-332672-fbwz8oxp 41 6 asparagine asparagine NN cord-332672-fbwz8oxp 41 7 at at IN cord-332672-fbwz8oxp 41 8 position position NN cord-332672-fbwz8oxp 41 9 479 479 CD cord-332672-fbwz8oxp 41 10 has have VBZ cord-332672-fbwz8oxp 41 11 a a DT cord-332672-fbwz8oxp 41 12 higher high JJR cord-332672-fbwz8oxp 41 13 binding bind VBG cord-332672-fbwz8oxp 41 14 affinity affinity NN cord-332672-fbwz8oxp 41 15 with with IN cord-332672-fbwz8oxp 41 16 human human JJ cord-332672-fbwz8oxp 41 17 ACE2 ACE2 NNP cord-332672-fbwz8oxp 41 18 and and CC cord-332672-fbwz8oxp 41 19 is be VBZ cord-332672-fbwz8oxp 41 20 likely likely JJ cord-332672-fbwz8oxp 41 21 to to TO cord-332672-fbwz8oxp 41 22 determine determine VB cord-332672-fbwz8oxp 41 23 whether whether IN cord-332672-fbwz8oxp 41 24 the the DT cord-332672-fbwz8oxp 41 25 virus virus NN cord-332672-fbwz8oxp 41 26 can can MD cord-332672-fbwz8oxp 41 27 infect infect VB cord-332672-fbwz8oxp 41 28 humans human NNS cord-332672-fbwz8oxp 41 29 ( ( -LRB- cord-332672-fbwz8oxp 41 30 Li Li NNP cord-332672-fbwz8oxp 41 31 F F NNP cord-332672-fbwz8oxp 41 32 , , , cord-332672-fbwz8oxp 41 33 2013 2013 CD cord-332672-fbwz8oxp 41 34 ) ) -RRB- cord-332672-fbwz8oxp 41 35 . . . cord-332672-fbwz8oxp 42 1 The the DT cord-332672-fbwz8oxp 42 2 change change NN cord-332672-fbwz8oxp 42 3 of of IN cord-332672-fbwz8oxp 42 4 the the DT cord-332672-fbwz8oxp 42 5 position position NN cord-332672-fbwz8oxp 42 6 479 479 CD cord-332672-fbwz8oxp 42 7 may may MD cord-332672-fbwz8oxp 42 8 have have VB cord-332672-fbwz8oxp 42 9 played play VBN cord-332672-fbwz8oxp 42 10 a a DT cord-332672-fbwz8oxp 42 11 role role NN cord-332672-fbwz8oxp 42 12 in in IN cord-332672-fbwz8oxp 42 13 the the DT cord-332672-fbwz8oxp 42 14 adaptation adaptation NN cord-332672-fbwz8oxp 42 15 of of IN cord-332672-fbwz8oxp 42 16 RS3367 rs3367 NN cord-332672-fbwz8oxp 42 17 to to IN cord-332672-fbwz8oxp 42 18 an an DT cord-332672-fbwz8oxp 42 19 ACE2 ACE2 NNP cord-332672-fbwz8oxp 42 20 receptor receptor NN cord-332672-fbwz8oxp 42 21 and and CC cord-332672-fbwz8oxp 42 22 the the DT cord-332672-fbwz8oxp 42 23 cross cross NN cord-332672-fbwz8oxp 42 24 - - JJ cord-332672-fbwz8oxp 42 25 species species JJ cord-332672-fbwz8oxp 42 26 infections infection NNS cord-332672-fbwz8oxp 42 27 of of IN cord-332672-fbwz8oxp 42 28 the the DT cord-332672-fbwz8oxp 42 29 virus virus NN cord-332672-fbwz8oxp 42 30 . . . cord-332672-fbwz8oxp 43 1 In in IN cord-332672-fbwz8oxp 43 2 summary summary NN cord-332672-fbwz8oxp 43 3 , , , cord-332672-fbwz8oxp 43 4 Ge Ge NNP cord-332672-fbwz8oxp 43 5 et et NNP cord-332672-fbwz8oxp 43 6 al al NNP cord-332672-fbwz8oxp 43 7 . . NNP cord-332672-fbwz8oxp 43 8 's 's POS cord-332672-fbwz8oxp 43 9 findings finding NNS cord-332672-fbwz8oxp 43 10 solved solve VBD cord-332672-fbwz8oxp 43 11 fundamental fundamental JJ cord-332672-fbwz8oxp 43 12 questions question NNS cord-332672-fbwz8oxp 43 13 surrounding surround VBG cord-332672-fbwz8oxp 43 14 the the DT cord-332672-fbwz8oxp 43 15 genesis genesis NN cord-332672-fbwz8oxp 43 16 of of IN cord-332672-fbwz8oxp 43 17 the the DT cord-332672-fbwz8oxp 43 18 SARS SARS NNP cord-332672-fbwz8oxp 43 19 - - HYPH cord-332672-fbwz8oxp 43 20 CoV CoV NNP cord-332672-fbwz8oxp 43 21 2003 2003 CD cord-332672-fbwz8oxp 43 22 epidemic epidemic NN cord-332672-fbwz8oxp 43 23 . . . cord-332672-fbwz8oxp 44 1 They -PRON- PRP cord-332672-fbwz8oxp 44 2 provided provide VBD cord-332672-fbwz8oxp 44 3 a a DT cord-332672-fbwz8oxp 44 4 plausible plausible JJ cord-332672-fbwz8oxp 44 5 scenario scenario NN cord-332672-fbwz8oxp 44 6 of of IN cord-332672-fbwz8oxp 44 7 direct direct JJ cord-332672-fbwz8oxp 44 8 bat bat NN cord-332672-fbwz8oxp 44 9 - - HYPH cord-332672-fbwz8oxp 44 10 tohuman tohuman NN cord-332672-fbwz8oxp 44 11 jump jump NN cord-332672-fbwz8oxp 44 12 of of IN cord-332672-fbwz8oxp 44 13 SARS SARS NNP cord-332672-fbwz8oxp 44 14 - - HYPH cord-332672-fbwz8oxp 44 15 CoV CoV NNP cord-332672-fbwz8oxp 44 16 without without IN cord-332672-fbwz8oxp 44 17 the the DT cord-332672-fbwz8oxp 44 18 transmission transmission NN cord-332672-fbwz8oxp 44 19 by by IN cord-332672-fbwz8oxp 44 20 interim interim JJ cord-332672-fbwz8oxp 44 21 hosts host NNS cord-332672-fbwz8oxp 44 22 . . . cord-332672-fbwz8oxp 45 1 Bats bat NNS cord-332672-fbwz8oxp 45 2 are be VBP cord-332672-fbwz8oxp 45 3 known know VBN cord-332672-fbwz8oxp 45 4 to to TO cord-332672-fbwz8oxp 45 5 be be VB cord-332672-fbwz8oxp 45 6 important important JJ cord-332672-fbwz8oxp 45 7 natural natural JJ cord-332672-fbwz8oxp 45 8 reservoirs reservoir NNS cord-332672-fbwz8oxp 45 9 of of IN cord-332672-fbwz8oxp 45 10 many many JJ cord-332672-fbwz8oxp 45 11 zoonotic zoonotic JJ cord-332672-fbwz8oxp 45 12 viruses virus NNS cord-332672-fbwz8oxp 45 13 , , , cord-332672-fbwz8oxp 45 14 for for IN cord-332672-fbwz8oxp 45 15 example example NN cord-332672-fbwz8oxp 45 16 , , , cord-332672-fbwz8oxp 45 17 the the DT cord-332672-fbwz8oxp 45 18 recently recently RB cord-332672-fbwz8oxp 45 19 emerged emerge VBD cord-332672-fbwz8oxp 45 20 Middle Middle NNP cord-332672-fbwz8oxp 45 21 East East NNP cord-332672-fbwz8oxp 45 22 respiratory respiratory JJ cord-332672-fbwz8oxp 45 23 syndrome syndrome NN cord-332672-fbwz8oxp 45 24 coronavirus coronavirus NN cord-332672-fbwz8oxp 45 25 ( ( -LRB- cord-332672-fbwz8oxp 45 26 MERS MERS NNP cord-332672-fbwz8oxp 45 27 - - HYPH cord-332672-fbwz8oxp 45 28 CoV CoV NNP cord-332672-fbwz8oxp 45 29 ) ) -RRB- cord-332672-fbwz8oxp 45 30 ( ( -LRB- cord-332672-fbwz8oxp 45 31 Chan Chan NNP cord-332672-fbwz8oxp 45 32 J J NNP cord-332672-fbwz8oxp 45 33 F F NNP cord-332672-fbwz8oxp 45 34 , , , cord-332672-fbwz8oxp 45 35 et et NNP cord-332672-fbwz8oxp 45 36 al al NNP cord-332672-fbwz8oxp 45 37 , , , cord-332672-fbwz8oxp 45 38 2012 2012 CD cord-332672-fbwz8oxp 45 39 ) ) -RRB- cord-332672-fbwz8oxp 45 40 . . . cord-332672-fbwz8oxp 46 1 The the DT cord-332672-fbwz8oxp 46 2 publication publication NN cord-332672-fbwz8oxp 46 3 by by IN cord-332672-fbwz8oxp 46 4 Ge Ge NNP cord-332672-fbwz8oxp 46 5 et et NNP cord-332672-fbwz8oxp 46 6 al al NNP cord-332672-fbwz8oxp 46 7 . . NNP cord-332672-fbwz8oxp 46 8 emphasized emphasize VBD cord-332672-fbwz8oxp 46 9 bats bat NNS cord-332672-fbwz8oxp 46 10 as as IN cord-332672-fbwz8oxp 46 11 public public JJ cord-332672-fbwz8oxp 46 12 health health NN cord-332672-fbwz8oxp 46 13 threats threat NNS cord-332672-fbwz8oxp 46 14 and and CC cord-332672-fbwz8oxp 46 15 highlighted highlight VBD cord-332672-fbwz8oxp 46 16 the the DT cord-332672-fbwz8oxp 46 17 importance importance NN cord-332672-fbwz8oxp 46 18 of of IN cord-332672-fbwz8oxp 46 19 epidemiological epidemiological JJ cord-332672-fbwz8oxp 46 20 and and CC cord-332672-fbwz8oxp 46 21 laboratory laboratory NN cord-332672-fbwz8oxp 46 22 studies study NNS cord-332672-fbwz8oxp 46 23 of of IN cord-332672-fbwz8oxp 46 24 bats bat NNS cord-332672-fbwz8oxp 46 25 - - HYPH cord-332672-fbwz8oxp 46 26 harboring harbor VBG cord-332672-fbwz8oxp 46 27 pathogens pathogen NNS cord-332672-fbwz8oxp 46 28 . . . cord-332672-fbwz8oxp 47 1 Full full JJ cord-332672-fbwz8oxp 47 2 - - HYPH cord-332672-fbwz8oxp 47 3 length length NN cord-332672-fbwz8oxp 47 4 genome genome NN cord-332672-fbwz8oxp 47 5 sequences sequence NNS cord-332672-fbwz8oxp 47 6 of of IN cord-332672-fbwz8oxp 47 7 two two CD cord-332672-fbwz8oxp 47 8 SARS SARS NNP cord-332672-fbwz8oxp 47 9 - - HYPH cord-332672-fbwz8oxp 47 10 like like JJ cord-332672-fbwz8oxp 47 11 coronaviruses coronaviruse NNS cord-332672-fbwz8oxp 47 12 in in IN cord-332672-fbwz8oxp 47 13 horseshoe horseshoe NN cord-332672-fbwz8oxp 47 14 bats bat NNS cord-332672-fbwz8oxp 47 15 and and CC cord-332672-fbwz8oxp 48 1 genetic genetic JJ cord-332672-fbwz8oxp 48 2 variation variation NN cord-332672-fbwz8oxp 48 3 analysis analysis NN cord-332672-fbwz8oxp 48 4 Difference difference NN cord-332672-fbwz8oxp 48 5 in in IN cord-332672-fbwz8oxp 48 6 receptor receptor NN cord-332672-fbwz8oxp 48 7 usage usage NN cord-332672-fbwz8oxp 48 8 between between IN cord-332672-fbwz8oxp 48 9 severe severe JJ cord-332672-fbwz8oxp 48 10 acute acute JJ cord-332672-fbwz8oxp 48 11 respiratory respiratory JJ cord-332672-fbwz8oxp 48 12 syndrome syndrome NN cord-332672-fbwz8oxp 48 13 ( ( -LRB- cord-332672-fbwz8oxp 48 14 SARS SARS NNP cord-332672-fbwz8oxp 48 15 ) ) -RRB- cord-332672-fbwz8oxp 48 16 coronavirus coronavirus NN cord-332672-fbwz8oxp 48 17 and and CC cord-332672-fbwz8oxp 48 18 SARS SARS NNP cord-332672-fbwz8oxp 48 19 - - HYPH cord-332672-fbwz8oxp 48 20 like like JJ cord-332672-fbwz8oxp 48 21 coronavirus coronavirus NN cord-332672-fbwz8oxp 48 22 of of IN cord-332672-fbwz8oxp 48 23 bat bat NN cord-332672-fbwz8oxp 48 24 origin origin NN cord-332672-fbwz8oxp 48 25 Cross Cross NNP cord-332672-fbwz8oxp 48 26 - - JJ cord-332672-fbwz8oxp 48 27 host host JJ cord-332672-fbwz8oxp 48 28 evolution evolution NN cord-332672-fbwz8oxp 48 29 of of IN cord-332672-fbwz8oxp 48 30 severe severe JJ cord-332672-fbwz8oxp 48 31 acute acute JJ cord-332672-fbwz8oxp 48 32 respiratory respiratory JJ cord-332672-fbwz8oxp 48 33 syndrome syndrome NN cord-332672-fbwz8oxp 48 34 coronavirus coronavirus NN cord-332672-fbwz8oxp 48 35 in in IN cord-332672-fbwz8oxp 48 36 palm palm NN cord-332672-fbwz8oxp 48 37 civet civet NN cord-332672-fbwz8oxp 48 38 and and CC cord-332672-fbwz8oxp 48 39 human human JJ cord-332672-fbwz8oxp 48 40 Molecular molecular JJ cord-332672-fbwz8oxp 48 41 evolution evolution NN cord-332672-fbwz8oxp 48 42 of of IN cord-332672-fbwz8oxp 48 43 the the DT cord-332672-fbwz8oxp 48 44 SARS SARS NNP cord-332672-fbwz8oxp 48 45 coronavirus coronavirus NN cord-332672-fbwz8oxp 48 46 during during IN cord-332672-fbwz8oxp 48 47 the the DT cord-332672-fbwz8oxp 48 48 course course NN cord-332672-fbwz8oxp 48 49 of of IN cord-332672-fbwz8oxp 48 50 the the DT cord-332672-fbwz8oxp 48 51 SARS SARS NNP cord-332672-fbwz8oxp 48 52 epidemic epidemic NN cord-332672-fbwz8oxp 48 53 in in IN cord-332672-fbwz8oxp 48 54 China China NNP cord-332672-fbwz8oxp 48 55 Detection Detection NNP cord-332672-fbwz8oxp 48 56 of of IN cord-332672-fbwz8oxp 48 57 novel novel JJ cord-332672-fbwz8oxp 48 58 SARS SARS NNP cord-332672-fbwz8oxp 48 59 - - HYPH cord-332672-fbwz8oxp 48 60 like like JJ cord-332672-fbwz8oxp 48 61 and and CC cord-332672-fbwz8oxp 48 62 other other JJ cord-332672-fbwz8oxp 48 63 coronaviruses coronaviruse NNS cord-332672-fbwz8oxp 48 64 in in IN cord-332672-fbwz8oxp 48 65 bats bat NNS cord-332672-fbwz8oxp 48 66 from from IN cord-332672-fbwz8oxp 48 67 Kenya Kenya NNP cord-332672-fbwz8oxp 48 68 SARS SARS NNP cord-332672-fbwz8oxp 48 69 - - HYPH cord-332672-fbwz8oxp 48 70 CoV CoV NNP cord-332672-fbwz8oxp 48 71 infection infection NN cord-332672-fbwz8oxp 48 72 in in IN cord-332672-fbwz8oxp 48 73 a a DT cord-332672-fbwz8oxp 48 74 restaurant restaurant NN cord-332672-fbwz8oxp 48 75 from from IN cord-332672-fbwz8oxp 48 76 palm palm NN cord-332672-fbwz8oxp 48 77 civet civet NNP