id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-014920-mmykzj9w	Wang, Shi-qun	Biological effects of HBV X protein on hepatocellular carcinogenesis in association with cellular factors	2008-05-10		.txt	text/plain	1017	55	31	The X protein (HBx) of Human hepatitis B virus (HBV) acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the development of Hepatocellular carcinoma (HCC). In addition, the viral X region appears to have pleiotropic effects that could also be involved in the oncogenic processes, including transcriptional activation of cellular growth regulatory genes, modulation of apoptosis and inhibition of nucleotide excision repair of damaged cellular DNA (8, 14, 16) . Many human hepatocellular carcinomas contain integrated HBV, and the viral X protein appears to have pleiotropic effects that could be involved in the oncogenic process. Putative tumor suppressor YueF affects the functions of hepatitis B virus X protein in hepatoma cell apoptosis and p53 expression The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression	./cache/cord-014920-mmykzj9w.txt	./txt/cord-014920-mmykzj9w.txt