id sid tid token lemma pos cord-263469-2w26l80a 1 1 key key JJ cord-263469-2w26l80a 1 2 : : : cord-263469-2w26l80a 1 3 cord-263469 cord-263469 NNP cord-263469-2w26l80a 1 4 - - HYPH cord-263469-2w26l80a 1 5 2w26l80a 2w26l80a CD cord-263469-2w26l80a 1 6 authors author NNS cord-263469-2w26l80a 1 7 : : : cord-263469-2w26l80a 1 8 Garry Garry NNP cord-263469-2w26l80a 1 9 , , , cord-263469-2w26l80a 1 10 Courtney Courtney NNP cord-263469-2w26l80a 1 11 E E NNP cord-263469-2w26l80a 1 12 ; ; : cord-263469-2w26l80a 1 13 Garry Garry NNP cord-263469-2w26l80a 1 14 , , , cord-263469-2w26l80a 1 15 Robert Robert NNP cord-263469-2w26l80a 1 16 F F NNP cord-263469-2w26l80a 1 17 title title NN cord-263469-2w26l80a 1 18 : : : cord-263469-2w26l80a 2 1 Proteomics Proteomics NNP cord-263469-2w26l80a 2 2 computational computational JJ cord-263469-2w26l80a 2 3 analyses analysis NNS cord-263469-2w26l80a 2 4 suggest suggest VBP cord-263469-2w26l80a 2 5 that that IN cord-263469-2w26l80a 2 6 the the DT cord-263469-2w26l80a 2 7 bornavirus bornavirus NNP cord-263469-2w26l80a 2 8 glycoprotein glycoprotein NN cord-263469-2w26l80a 2 9 is be VBZ cord-263469-2w26l80a 2 10 a a DT cord-263469-2w26l80a 2 11 class class NN cord-263469-2w26l80a 2 12 III iii CD cord-263469-2w26l80a 2 13 viral viral JJ cord-263469-2w26l80a 2 14 fusion fusion NN cord-263469-2w26l80a 2 15 protein protein NN cord-263469-2w26l80a 2 16 ( ( -LRB- cord-263469-2w26l80a 2 17 γ γ NNP cord-263469-2w26l80a 2 18 penetrene penetrene NNP cord-263469-2w26l80a 2 19 ) ) -RRB- cord-263469-2w26l80a 2 20 date date NN cord-263469-2w26l80a 2 21 : : : cord-263469-2w26l80a 2 22 2009 2009 CD cord-263469-2w26l80a 2 23 - - SYM cord-263469-2w26l80a 2 24 09 09 CD cord-263469-2w26l80a 2 25 - - SYM cord-263469-2w26l80a 2 26 18 18 CD cord-263469-2w26l80a 2 27 journal journal NN cord-263469-2w26l80a 2 28 : : : cord-263469-2w26l80a 3 1 Virol Virol NNP cord-263469-2w26l80a 3 2 J J NNP cord-263469-2w26l80a 3 3 DOI DOI NNP cord-263469-2w26l80a 3 4 : : : cord-263469-2w26l80a 3 5 10.1186/1743 10.1186/1743 CD cord-263469-2w26l80a 3 6 - - HYPH cord-263469-2w26l80a 3 7 422x-6 422x-6 CD cord-263469-2w26l80a 3 8 - - SYM cord-263469-2w26l80a 3 9 145 145 CD cord-263469-2w26l80a 4 1 sha sha NNP cord-263469-2w26l80a 4 2 : : : cord-263469-2w26l80a 4 3 0f157fb0a719dd0d52fb921fb1369ccb6477636e 0f157fb0a719dd0d52fb921fb1369ccb6477636e LS cord-263469-2w26l80a 4 4 doc_id doc_id NNPS cord-263469-2w26l80a 5 1 : : : cord-263469-2w26l80a 5 2 263469 263469 CD cord-263469-2w26l80a 5 3 cord_uid cord_uid NNS cord-263469-2w26l80a 5 4 : : : cord-263469-2w26l80a 6 1 2w26l80a 2w26l80a CD cord-263469-2w26l80a 6 2 BACKGROUND background NN cord-263469-2w26l80a 6 3 : : : cord-263469-2w26l80a 7 1 Borna Borna NNP cord-263469-2w26l80a 7 2 disease disease NN cord-263469-2w26l80a 7 3 virus virus NN cord-263469-2w26l80a 7 4 ( ( -LRB- cord-263469-2w26l80a 7 5 BDV BDV NNP cord-263469-2w26l80a 7 6 ) ) -RRB- cord-263469-2w26l80a 7 7 is be VBZ cord-263469-2w26l80a 7 8 the the DT cord-263469-2w26l80a 7 9 type type NN cord-263469-2w26l80a 7 10 member member NN cord-263469-2w26l80a 7 11 of of IN cord-263469-2w26l80a 7 12 the the DT cord-263469-2w26l80a 7 13 Bornaviridae Bornaviridae NNP cord-263469-2w26l80a 7 14 , , , cord-263469-2w26l80a 7 15 a a DT cord-263469-2w26l80a 7 16 family family NN cord-263469-2w26l80a 7 17 of of IN cord-263469-2w26l80a 7 18 viruses virus NNS cord-263469-2w26l80a 7 19 that that WDT cord-263469-2w26l80a 7 20 induce induce VBP cord-263469-2w26l80a 7 21 often often RB cord-263469-2w26l80a 7 22 fatal fatal JJ cord-263469-2w26l80a 7 23 neurological neurological JJ cord-263469-2w26l80a 7 24 diseases disease NNS cord-263469-2w26l80a 7 25 in in IN cord-263469-2w26l80a 7 26 horses horse NNS cord-263469-2w26l80a 7 27 , , , cord-263469-2w26l80a 7 28 sheep sheep NNS cord-263469-2w26l80a 7 29 and and CC cord-263469-2w26l80a 7 30 other other JJ cord-263469-2w26l80a 7 31 animals animal NNS cord-263469-2w26l80a 7 32 , , , cord-263469-2w26l80a 7 33 and and CC cord-263469-2w26l80a 7 34 have have VBP cord-263469-2w26l80a 7 35 been be VBN cord-263469-2w26l80a 7 36 proposed propose VBN cord-263469-2w26l80a 7 37 to to TO cord-263469-2w26l80a 7 38 have have VB cord-263469-2w26l80a 7 39 roles role NNS cord-263469-2w26l80a 7 40 in in IN cord-263469-2w26l80a 7 41 certain certain JJ cord-263469-2w26l80a 7 42 psychiatric psychiatric JJ cord-263469-2w26l80a 7 43 diseases disease NNS cord-263469-2w26l80a 7 44 of of IN cord-263469-2w26l80a 7 45 humans human NNS cord-263469-2w26l80a 7 46 . . . cord-263469-2w26l80a 8 1 The the DT cord-263469-2w26l80a 8 2 BDV BDV NNP cord-263469-2w26l80a 8 3 glycoprotein glycoprotein NN cord-263469-2w26l80a 8 4 ( ( -LRB- cord-263469-2w26l80a 8 5 G g NN cord-263469-2w26l80a 8 6 ) ) -RRB- cord-263469-2w26l80a 8 7 is be VBZ cord-263469-2w26l80a 8 8 an an DT cord-263469-2w26l80a 8 9 extensively extensively RB cord-263469-2w26l80a 8 10 glycosylated glycosylate VBN cord-263469-2w26l80a 8 11 protein protein NN cord-263469-2w26l80a 8 12 that that WDT cord-263469-2w26l80a 8 13 migrates migrate VBZ cord-263469-2w26l80a 8 14 with with IN cord-263469-2w26l80a 8 15 an an DT cord-263469-2w26l80a 8 16 apparent apparent JJ cord-263469-2w26l80a 8 17 molecular molecular JJ cord-263469-2w26l80a 8 18 mass mass NN cord-263469-2w26l80a 8 19 of of IN cord-263469-2w26l80a 8 20 84,000 84,000 CD cord-263469-2w26l80a 8 21 to to TO cord-263469-2w26l80a 8 22 94,000 94,000 CD cord-263469-2w26l80a 8 23 kilodaltons kilodalton NNS cord-263469-2w26l80a 8 24 ( ( -LRB- cord-263469-2w26l80a 8 25 kDa kDa NNP cord-263469-2w26l80a 8 26 ) ) -RRB- cord-263469-2w26l80a 8 27 . . . cord-263469-2w26l80a 9 1 BDV BDV NNP cord-263469-2w26l80a 9 2 G G NNP cord-263469-2w26l80a 9 3 is be VBZ cord-263469-2w26l80a 9 4 post post JJ cord-263469-2w26l80a 9 5 - - JJ cord-263469-2w26l80a 9 6 translationally translationally RB cord-263469-2w26l80a 9 7 cleaved cleave VBN cord-263469-2w26l80a 9 8 by by IN cord-263469-2w26l80a 9 9 the the DT cord-263469-2w26l80a 9 10 cellular cellular JJ cord-263469-2w26l80a 9 11 subtilisin subtilisin NNS cord-263469-2w26l80a 9 12 - - HYPH cord-263469-2w26l80a 9 13 like like JJ cord-263469-2w26l80a 9 14 protease protease NN cord-263469-2w26l80a 9 15 furin furin NN cord-263469-2w26l80a 9 16 into into IN cord-263469-2w26l80a 9 17 two two CD cord-263469-2w26l80a 9 18 subunits subunit NNS cord-263469-2w26l80a 9 19 , , , cord-263469-2w26l80a 9 20 a a DT cord-263469-2w26l80a 9 21 41 41 CD cord-263469-2w26l80a 9 22 kDa kDa NNP cord-263469-2w26l80a 9 23 amino amino NN cord-263469-2w26l80a 9 24 terminal terminal NN cord-263469-2w26l80a 9 25 protein protein NN cord-263469-2w26l80a 9 26 GP1 GP1 NNP cord-263469-2w26l80a 9 27 and and CC cord-263469-2w26l80a 9 28 a a DT cord-263469-2w26l80a 9 29 43 43 CD cord-263469-2w26l80a 9 30 kDa kDa NNP cord-263469-2w26l80a 9 31 carboxyl carboxyl NNP cord-263469-2w26l80a 9 32 terminal terminal NN cord-263469-2w26l80a 9 33 protein protein NN cord-263469-2w26l80a 9 34 GP2 GP2 NNP cord-263469-2w26l80a 9 35 . . . cord-263469-2w26l80a 10 1 RESULTS result NNS cord-263469-2w26l80a 10 2 : : : cord-263469-2w26l80a 11 1 Class class NN cord-263469-2w26l80a 11 2 III iii CD cord-263469-2w26l80a 11 3 viral viral JJ cord-263469-2w26l80a 11 4 fusion fusion NN cord-263469-2w26l80a 11 5 proteins protein NNS cord-263469-2w26l80a 11 6 ( ( -LRB- cord-263469-2w26l80a 11 7 VFP VFP NNP cord-263469-2w26l80a 11 8 ) ) -RRB- cord-263469-2w26l80a 11 9 encoded encode VBN cord-263469-2w26l80a 11 10 by by IN cord-263469-2w26l80a 11 11 members member NNS cord-263469-2w26l80a 11 12 of of IN cord-263469-2w26l80a 11 13 the the DT cord-263469-2w26l80a 11 14 Rhabdoviridae Rhabdoviridae NNP cord-263469-2w26l80a 11 15 , , , cord-263469-2w26l80a 11 16 Herpesviridae Herpesviridae NNP cord-263469-2w26l80a 11 17 and and CC cord-263469-2w26l80a 11 18 Baculoviridae Baculoviridae NNP cord-263469-2w26l80a 11 19 have have VB cord-263469-2w26l80a 11 20 an an DT cord-263469-2w26l80a 11 21 internal internal JJ cord-263469-2w26l80a 11 22 fusion fusion NN cord-263469-2w26l80a 11 23 domain domain NN cord-263469-2w26l80a 11 24 comprised comprise VBN cord-263469-2w26l80a 11 25 of of IN cord-263469-2w26l80a 11 26 beta beta JJ cord-263469-2w26l80a 11 27 sheets sheet NNS cord-263469-2w26l80a 11 28 , , , cord-263469-2w26l80a 11 29 other other JJ cord-263469-2w26l80a 11 30 beta beta NN cord-263469-2w26l80a 11 31 sheet sheet NN cord-263469-2w26l80a 11 32 domains domain NNS cord-263469-2w26l80a 11 33 , , , cord-263469-2w26l80a 11 34 an an DT cord-263469-2w26l80a 11 35 extended extended JJ cord-263469-2w26l80a 11 36 alpha alpha NN cord-263469-2w26l80a 11 37 helical helical JJ cord-263469-2w26l80a 11 38 domain domain NN cord-263469-2w26l80a 11 39 , , , cord-263469-2w26l80a 11 40 a a DT cord-263469-2w26l80a 11 41 membrane membrane NN cord-263469-2w26l80a 11 42 proximal proximal JJ cord-263469-2w26l80a 11 43 stem stem NN cord-263469-2w26l80a 11 44 domain domain NN cord-263469-2w26l80a 11 45 and and CC cord-263469-2w26l80a 11 46 a a DT cord-263469-2w26l80a 11 47 carboxyl carboxyl NN cord-263469-2w26l80a 11 48 terminal terminal NN cord-263469-2w26l80a 11 49 anchor anchor NN cord-263469-2w26l80a 11 50 . . . cord-263469-2w26l80a 12 1 Proteomics Proteomics NNP cord-263469-2w26l80a 12 2 computational computational JJ cord-263469-2w26l80a 12 3 analyses analysis NNS cord-263469-2w26l80a 12 4 suggest suggest VBP cord-263469-2w26l80a 12 5 that that IN cord-263469-2w26l80a 12 6 the the DT cord-263469-2w26l80a 12 7 structural structural JJ cord-263469-2w26l80a 12 8 / / SYM cord-263469-2w26l80a 12 9 functional functional JJ cord-263469-2w26l80a 12 10 motifs motif NNS cord-263469-2w26l80a 12 11 that that WDT cord-263469-2w26l80a 12 12 characterize characterize VBP cord-263469-2w26l80a 12 13 class class NN cord-263469-2w26l80a 12 14 III III NNP cord-263469-2w26l80a 12 15 VFP VFP NNP cord-263469-2w26l80a 12 16 are be VBP cord-263469-2w26l80a 12 17 located locate VBN cord-263469-2w26l80a 12 18 collinearly collinearly RB cord-263469-2w26l80a 12 19 in in IN cord-263469-2w26l80a 12 20 BDV BDV NNP cord-263469-2w26l80a 12 21 G. G. NNP cord-263469-2w26l80a 12 22 Structural Structural NNP cord-263469-2w26l80a 12 23 models model NNS cord-263469-2w26l80a 12 24 were be VBD cord-263469-2w26l80a 12 25 established establish VBN cord-263469-2w26l80a 12 26 for for IN cord-263469-2w26l80a 12 27 BDV BDV NNP cord-263469-2w26l80a 12 28 G G NNP cord-263469-2w26l80a 12 29 based base VBN cord-263469-2w26l80a 12 30 on on IN cord-263469-2w26l80a 12 31 the the DT cord-263469-2w26l80a 12 32 post post JJ cord-263469-2w26l80a 12 33 - - JJ cord-263469-2w26l80a 12 34 fusion fusion JJ cord-263469-2w26l80a 12 35 structure structure NN cord-263469-2w26l80a 12 36 of of IN cord-263469-2w26l80a 12 37 a a DT cord-263469-2w26l80a 12 38 prototypic prototypic JJ cord-263469-2w26l80a 12 39 class class NN cord-263469-2w26l80a 12 40 III III NNP cord-263469-2w26l80a 12 41 VFP VFP NNP cord-263469-2w26l80a 12 42 , , , cord-263469-2w26l80a 12 43 vesicular vesicular JJ cord-263469-2w26l80a 12 44 stomatitis stomatitis NN cord-263469-2w26l80a 12 45 virus virus NN cord-263469-2w26l80a 12 46 glycoprotein glycoprotein NN cord-263469-2w26l80a 12 47 ( ( -LRB- cord-263469-2w26l80a 12 48 VSV VSV NNP cord-263469-2w26l80a 12 49 G G NNP cord-263469-2w26l80a 12 50 ) ) -RRB- cord-263469-2w26l80a 12 51 . . . cord-263469-2w26l80a 13 1 CONCLUSION conclusion NN cord-263469-2w26l80a 13 2 : : : cord-263469-2w26l80a 14 1 These these DT cord-263469-2w26l80a 14 2 results result NNS cord-263469-2w26l80a 14 3 suggest suggest VBP cord-263469-2w26l80a 14 4 that that IN cord-263469-2w26l80a 14 5 G g NN cord-263469-2w26l80a 14 6 encoded encode VBN cord-263469-2w26l80a 14 7 by by IN cord-263469-2w26l80a 14 8 members member NNS cord-263469-2w26l80a 14 9 of of IN cord-263469-2w26l80a 14 10 the the DT cord-263469-2w26l80a 14 11 Bornavirdae Bornavirdae NNP cord-263469-2w26l80a 14 12 are be VBP cord-263469-2w26l80a 14 13 class class NN cord-263469-2w26l80a 14 14 III iii CD cord-263469-2w26l80a 14 15 VFPs vfp NNS cord-263469-2w26l80a 14 16 ( ( -LRB- cord-263469-2w26l80a 14 17 gamma gamma NN cord-263469-2w26l80a 14 18 - - HYPH cord-263469-2w26l80a 14 19 penetrenes penetrenes NNP cord-263469-2w26l80a 14 20 ) ) -RRB- cord-263469-2w26l80a 14 21 . . . cord-263469-2w26l80a 15 1 Members member NNS cord-263469-2w26l80a 15 2 of of IN cord-263469-2w26l80a 15 3 the the DT cord-263469-2w26l80a 15 4 Bornaviridae Bornaviridae NNP cord-263469-2w26l80a 15 5 are be VBP cord-263469-2w26l80a 15 6 enveloped envelop VBN cord-263469-2w26l80a 15 7 with with IN cord-263469-2w26l80a 15 8 nonsegmented nonsegmented JJ cord-263469-2w26l80a 15 9 negative negative JJ cord-263469-2w26l80a 15 10 - - HYPH cord-263469-2w26l80a 15 11 stranded strand VBN cord-263469-2w26l80a 15 12 RNA RNA NNP cord-263469-2w26l80a 15 13 genomes genome NNS cord-263469-2w26l80a 15 14 . . . cord-263469-2w26l80a 16 1 The the DT cord-263469-2w26l80a 16 2 type type NN cord-263469-2w26l80a 16 3 member member NN cord-263469-2w26l80a 16 4 is be VBZ cord-263469-2w26l80a 16 5 Borna Borna NNP cord-263469-2w26l80a 16 6 disease disease NN cord-263469-2w26l80a 16 7 virus virus NN cord-263469-2w26l80a 16 8 ( ( -LRB- cord-263469-2w26l80a 16 9 BDV BDV NNP cord-263469-2w26l80a 16 10 ) ) -RRB- cord-263469-2w26l80a 16 11 , , , cord-263469-2w26l80a 16 12 the the DT cord-263469-2w26l80a 16 13 causative causative JJ cord-263469-2w26l80a 16 14 agent agent NN cord-263469-2w26l80a 16 15 of of IN cord-263469-2w26l80a 16 16 Borna Borna NNP cord-263469-2w26l80a 16 17 disease disease NN cord-263469-2w26l80a 16 18 , , , cord-263469-2w26l80a 16 19 an an DT cord-263469-2w26l80a 16 20 often often RB cord-263469-2w26l80a 16 21 fatal fatal JJ cord-263469-2w26l80a 16 22 neurological neurological JJ cord-263469-2w26l80a 16 23 disease disease NN cord-263469-2w26l80a 16 24 occurring occur VBG cord-263469-2w26l80a 16 25 mainly mainly RB cord-263469-2w26l80a 16 26 in in IN cord-263469-2w26l80a 16 27 horses horse NNS cord-263469-2w26l80a 16 28 and and CC cord-263469-2w26l80a 16 29 sheep sheep NNS cord-263469-2w26l80a 16 30 in in IN cord-263469-2w26l80a 16 31 endemic endemic JJ cord-263469-2w26l80a 16 32 regions region NNS cord-263469-2w26l80a 16 33 of of IN cord-263469-2w26l80a 16 34 central central JJ cord-263469-2w26l80a 16 35 Europe Europe NNP cord-263469-2w26l80a 16 36 . . . cord-263469-2w26l80a 17 1 The the DT cord-263469-2w26l80a 17 2 natural natural JJ cord-263469-2w26l80a 17 3 host host NN cord-263469-2w26l80a 17 4 range range NN cord-263469-2w26l80a 17 5 , , , cord-263469-2w26l80a 17 6 prevalence prevalence NN cord-263469-2w26l80a 17 7 , , , cord-263469-2w26l80a 17 8 and and CC cord-263469-2w26l80a 17 9 geographic geographic JJ cord-263469-2w26l80a 17 10 distribution distribution NN cord-263469-2w26l80a 17 11 of of IN cord-263469-2w26l80a 17 12 BDV BDV NNP cord-263469-2w26l80a 17 13 are be VBP cord-263469-2w26l80a 17 14 broad broad JJ cord-263469-2w26l80a 17 15 [ [ -LRB- cord-263469-2w26l80a 17 16 1 1 CD cord-263469-2w26l80a 17 17 ] ] -RRB- cord-263469-2w26l80a 17 18 . . . cord-263469-2w26l80a 18 1 For for IN cord-263469-2w26l80a 18 2 example example NN cord-263469-2w26l80a 18 3 , , , cord-263469-2w26l80a 18 4 recent recent JJ cord-263469-2w26l80a 18 5 studies study NNS cord-263469-2w26l80a 18 6 demonstrated demonstrate VBD cord-263469-2w26l80a 18 7 the the DT cord-263469-2w26l80a 18 8 existence existence NN cord-263469-2w26l80a 18 9 of of IN cord-263469-2w26l80a 18 10 an an DT cord-263469-2w26l80a 18 11 avian avian JJ cord-263469-2w26l80a 18 12 reservoir reservoir NN cord-263469-2w26l80a 18 13 of of IN cord-263469-2w26l80a 18 14 diverse diverse JJ cord-263469-2w26l80a 18 15 bornaviruses bornaviruse NNS cord-263469-2w26l80a 18 16 [ [ -LRB- cord-263469-2w26l80a 18 17 2 2 CD cord-263469-2w26l80a 18 18 ] ] -RRB- cord-263469-2w26l80a 18 19 and and CC cord-263469-2w26l80a 18 20 provided provide VBD cord-263469-2w26l80a 18 21 evidence evidence NN cord-263469-2w26l80a 18 22 that that IN cord-263469-2w26l80a 18 23 bornaviruses bornaviruse NNS cord-263469-2w26l80a 18 24 are be VBP cord-263469-2w26l80a 18 25 the the DT cord-263469-2w26l80a 18 26 etiologic etiologic JJ cord-263469-2w26l80a 18 27 agent agent NN cord-263469-2w26l80a 18 28 for for IN cord-263469-2w26l80a 18 29 proventricular proventricular JJ cord-263469-2w26l80a 18 30 dilatation dilatation NN cord-263469-2w26l80a 18 31 disease disease NN cord-263469-2w26l80a 18 32 , , , cord-263469-2w26l80a 18 33 a a DT cord-263469-2w26l80a 18 34 neuroinflammatory neuroinflammatory JJ cord-263469-2w26l80a 18 35 disease disease NN cord-263469-2w26l80a 18 36 of of IN cord-263469-2w26l80a 18 37 psittacine psittacine JJ cord-263469-2w26l80a 18 38 birds bird NNS cord-263469-2w26l80a 18 39 [ [ -LRB- cord-263469-2w26l80a 18 40 3 3 CD cord-263469-2w26l80a 18 41 ] ] -RRB- cord-263469-2w26l80a 18 42 . . . cord-263469-2w26l80a 19 1 It -PRON- PRP cord-263469-2w26l80a 19 2 is be VBZ cord-263469-2w26l80a 19 3 yet yet RB cord-263469-2w26l80a 19 4 to to TO cord-263469-2w26l80a 19 5 be be VB cord-263469-2w26l80a 19 6 established establish VBN cord-263469-2w26l80a 19 7 whether whether IN cord-263469-2w26l80a 19 8 bornaviruses bornaviruse NNS cord-263469-2w26l80a 19 9 causes cause VBZ cord-263469-2w26l80a 19 10 any any DT cord-263469-2w26l80a 19 11 overt overt JJ cord-263469-2w26l80a 19 12 disease disease NN cord-263469-2w26l80a 19 13 in in IN cord-263469-2w26l80a 19 14 humans human NNS cord-263469-2w26l80a 19 15 . . . cord-263469-2w26l80a 20 1 However however RB cord-263469-2w26l80a 20 2 , , , cord-263469-2w26l80a 20 3 correlative correlative JJ cord-263469-2w26l80a 20 4 evidence evidence NN cord-263469-2w26l80a 20 5 exists exist VBZ cord-263469-2w26l80a 20 6 linking link VBG cord-263469-2w26l80a 20 7 BDV BDV NNP cord-263469-2w26l80a 20 8 infection infection NN cord-263469-2w26l80a 20 9 with with IN cord-263469-2w26l80a 20 10 neuropsychiatric neuropsychiatric JJ cord-263469-2w26l80a 20 11 disorders disorder NNS cord-263469-2w26l80a 20 12 , , , cord-263469-2w26l80a 20 13 such such JJ cord-263469-2w26l80a 20 14 as as IN cord-263469-2w26l80a 20 15 bipolar bipolar JJ cord-263469-2w26l80a 20 16 disorder disorder NN cord-263469-2w26l80a 20 17 [ [ -LRB- cord-263469-2w26l80a 20 18 4 4 CD cord-263469-2w26l80a 20 19 , , , cord-263469-2w26l80a 20 20 5 5 CD cord-263469-2w26l80a 20 21 ] ] -RRB- cord-263469-2w26l80a 20 22 . . . cord-263469-2w26l80a 21 1 BDV BDV NNP cord-263469-2w26l80a 21 2 is be VBZ cord-263469-2w26l80a 21 3 noncytolytic noncytolytic JJ cord-263469-2w26l80a 21 4 and and CC cord-263469-2w26l80a 21 5 highly highly RB cord-263469-2w26l80a 21 6 neurotropic neurotropic NNP cord-263469-2w26l80a 21 7 [ [ -LRB- cord-263469-2w26l80a 21 8 6 6 CD cord-263469-2w26l80a 21 9 ] ] -RRB- cord-263469-2w26l80a 21 10 . . . cord-263469-2w26l80a 22 1 Although although IN cord-263469-2w26l80a 22 2 viral viral JJ cord-263469-2w26l80a 22 3 RNA RNA NNP cord-263469-2w26l80a 22 4 and and CC cord-263469-2w26l80a 22 5 proteins protein NNS cord-263469-2w26l80a 22 6 are be VBP cord-263469-2w26l80a 22 7 readily readily RB cord-263469-2w26l80a 22 8 detectable detectable JJ cord-263469-2w26l80a 22 9 in in IN cord-263469-2w26l80a 22 10 BDVinfected bdvinfected JJ cord-263469-2w26l80a 22 11 cells cell NNS cord-263469-2w26l80a 22 12 , , , cord-263469-2w26l80a 22 13 production production NN cord-263469-2w26l80a 22 14 of of IN cord-263469-2w26l80a 22 15 cell cell NN cord-263469-2w26l80a 22 16 - - HYPH cord-263469-2w26l80a 22 17 free free JJ cord-263469-2w26l80a 22 18 virions virion NNS cord-263469-2w26l80a 22 19 or or CC cord-263469-2w26l80a 22 20 cell cell NN cord-263469-2w26l80a 22 21 - - HYPH cord-263469-2w26l80a 22 22 associated associate VBN cord-263469-2w26l80a 22 23 infectivity infectivity NN cord-263469-2w26l80a 22 24 is be VBZ cord-263469-2w26l80a 22 25 absent absent JJ cord-263469-2w26l80a 22 26 or or CC cord-263469-2w26l80a 22 27 extremely extremely RB cord-263469-2w26l80a 22 28 low low JJ cord-263469-2w26l80a 22 29 [ [ -LRB- cord-263469-2w26l80a 22 30 7 7 CD cord-263469-2w26l80a 22 31 ] ] -RRB- cord-263469-2w26l80a 22 32 . . . cord-263469-2w26l80a 23 1 BDV BDV NNP cord-263469-2w26l80a 23 2 propagates propagate VBZ cord-263469-2w26l80a 23 3 via via IN cord-263469-2w26l80a 23 4 cell cell NN cord-263469-2w26l80a 23 5 - - HYPH cord-263469-2w26l80a 23 6 to to IN cord-263469-2w26l80a 23 7 - - HYPH cord-263469-2w26l80a 23 8 cell cell NN cord-263469-2w26l80a 23 9 spread spread NN cord-263469-2w26l80a 23 10 within within IN cord-263469-2w26l80a 23 11 the the DT cord-263469-2w26l80a 23 12 central central JJ cord-263469-2w26l80a 23 13 nervous nervous JJ cord-263469-2w26l80a 23 14 system system NN cord-263469-2w26l80a 23 15 and and CC cord-263469-2w26l80a 23 16 cultured cultured JJ cord-263469-2w26l80a 23 17 cells cell NNS cord-263469-2w26l80a 23 18 in in IN cord-263469-2w26l80a 23 19 the the DT cord-263469-2w26l80a 23 20 absence absence NN cord-263469-2w26l80a 23 21 of of IN cord-263469-2w26l80a 23 22 detectable detectable JJ cord-263469-2w26l80a 23 23 assembled assemble VBN cord-263469-2w26l80a 23 24 virions virion NNS cord-263469-2w26l80a 23 25 [ [ -LRB- cord-263469-2w26l80a 23 26 8 8 CD cord-263469-2w26l80a 23 27 , , , cord-263469-2w26l80a 23 28 9 9 CD cord-263469-2w26l80a 23 29 ] ] -RRB- cord-263469-2w26l80a 23 30 . . . cord-263469-2w26l80a 24 1 It -PRON- PRP cord-263469-2w26l80a 24 2 is be VBZ cord-263469-2w26l80a 24 3 likely likely JJ cord-263469-2w26l80a 24 4 that that IN cord-263469-2w26l80a 24 5 BDV BDV NNP cord-263469-2w26l80a 24 6 initially initially RB cord-263469-2w26l80a 24 7 inter inter JJ cord-263469-2w26l80a 24 8 - - NNS cord-263469-2w26l80a 24 9 acts act NNS cord-263469-2w26l80a 24 10 with with IN cord-263469-2w26l80a 24 11 the the DT cord-263469-2w26l80a 24 12 plasma plasma NN cord-263469-2w26l80a 24 13 membrane membrane NN cord-263469-2w26l80a 24 14 , , , cord-263469-2w26l80a 24 15 followed follow VBN cord-263469-2w26l80a 24 16 by by IN cord-263469-2w26l80a 24 17 endocytosis endocytosis NN cord-263469-2w26l80a 24 18 and and CC cord-263469-2w26l80a 24 19 penetration penetration NN cord-263469-2w26l80a 24 20 by by IN cord-263469-2w26l80a 24 21 membrane membrane NN cord-263469-2w26l80a 24 22 fusion fusion NN cord-263469-2w26l80a 24 23 ; ; : cord-263469-2w26l80a 24 24 cell cell NN cord-263469-2w26l80a 24 25 - - HYPH cord-263469-2w26l80a 24 26 to to IN cord-263469-2w26l80a 24 27 - - HYPH cord-263469-2w26l80a 24 28 cell cell NN cord-263469-2w26l80a 24 29 spread spread NN cord-263469-2w26l80a 24 30 of of IN cord-263469-2w26l80a 24 31 bornaviruses bornaviruse NNS cord-263469-2w26l80a 24 32 may may MD cord-263469-2w26l80a 24 33 involve involve VB cord-263469-2w26l80a 24 34 distinct distinct JJ cord-263469-2w26l80a 24 35 mechanisms mechanism NNS cord-263469-2w26l80a 24 36 [ [ -LRB- cord-263469-2w26l80a 24 37 10 10 CD cord-263469-2w26l80a 24 38 ] ] -RRB- cord-263469-2w26l80a 24 39 . . . cord-263469-2w26l80a 25 1 The the DT cord-263469-2w26l80a 25 2 BDV BDV NNP cord-263469-2w26l80a 25 3 genome genome NN cord-263469-2w26l80a 25 4 contains contain VBZ cord-263469-2w26l80a 25 5 at at IN cord-263469-2w26l80a 25 6 least least JJS cord-263469-2w26l80a 25 7 six six CD cord-263469-2w26l80a 25 8 open open JJ cord-263469-2w26l80a 25 9 reading reading NN cord-263469-2w26l80a 25 10 frames frame NNS cord-263469-2w26l80a 25 11 ( ( -LRB- cord-263469-2w26l80a 25 12 ORF ORF NNP cord-263469-2w26l80a 25 13 ) ) -RRB- cord-263469-2w26l80a 25 14 , , , cord-263469-2w26l80a 25 15 and and CC cord-263469-2w26l80a 25 16 the the DT cord-263469-2w26l80a 25 17 product product NN cord-263469-2w26l80a 25 18 of of IN cord-263469-2w26l80a 25 19 BDV BDV NNP cord-263469-2w26l80a 25 20 ORF ORF NNP cord-263469-2w26l80a 25 21 IV IV NNP cord-263469-2w26l80a 25 22 corresponds correspond VBZ cord-263469-2w26l80a 25 23 to to IN cord-263469-2w26l80a 25 24 the the DT cord-263469-2w26l80a 25 25 type type NN cord-263469-2w26l80a 25 26 I -PRON- PRP cord-263469-2w26l80a 25 27 surface surface VBP cord-263469-2w26l80a 25 28 glycoproteins glycoprotein NNS cord-263469-2w26l80a 25 29 found find VBN cord-263469-2w26l80a 25 30 in in IN cord-263469-2w26l80a 25 31 other other JJ cord-263469-2w26l80a 25 32 viruses virus NNS cord-263469-2w26l80a 25 33 of of IN cord-263469-2w26l80a 25 34 the the DT cord-263469-2w26l80a 25 35 order order NN cord-263469-2w26l80a 25 36 Mononegavirales Mononegavirales NNP cord-263469-2w26l80a 25 37 . . . cord-263469-2w26l80a 26 1 The the DT cord-263469-2w26l80a 26 2 BDV BDV NNP cord-263469-2w26l80a 26 3 glycoprotein glycoprotein NN cord-263469-2w26l80a 26 4 ( ( -LRB- cord-263469-2w26l80a 26 5 G g NN cord-263469-2w26l80a 26 6 , , , cord-263469-2w26l80a 26 7 GP GP NNP cord-263469-2w26l80a 26 8 - - HYPH cord-263469-2w26l80a 26 9 C C NNP cord-263469-2w26l80a 26 10 , , , cord-263469-2w26l80a 26 11 gp84 gp84 NNP cord-263469-2w26l80a 26 12 ) ) -RRB- cord-263469-2w26l80a 26 13 migrates migrate VBZ cord-263469-2w26l80a 26 14 due due JJ cord-263469-2w26l80a 26 15 to to IN cord-263469-2w26l80a 26 16 extensive extensive JJ cord-263469-2w26l80a 26 17 glycosylation glycosylation NN cord-263469-2w26l80a 26 18 with with IN cord-263469-2w26l80a 26 19 an an DT cord-263469-2w26l80a 26 20 apparent apparent JJ cord-263469-2w26l80a 26 21 molecular molecular JJ cord-263469-2w26l80a 26 22 mass mass NN cord-263469-2w26l80a 26 23 of of IN cord-263469-2w26l80a 26 24 84,000 84,000 CD cord-263469-2w26l80a 26 25 to to TO cord-263469-2w26l80a 26 26 94,000 94,000 CD cord-263469-2w26l80a 26 27 kilodaltons kilodalton NNS cord-263469-2w26l80a 26 28 ( ( -LRB- cord-263469-2w26l80a 26 29 kDa kDa NNP cord-263469-2w26l80a 26 30 ) ) -RRB- cord-263469-2w26l80a 26 31 . . . cord-263469-2w26l80a 27 1 BDV BDV NNP cord-263469-2w26l80a 27 2 G G NNP cord-263469-2w26l80a 27 3 is be VBZ cord-263469-2w26l80a 27 4 post post JJ cord-263469-2w26l80a 27 5 - - JJ cord-263469-2w26l80a 27 6 translationally translationally RB cord-263469-2w26l80a 27 7 cleaved cleave VBN cord-263469-2w26l80a 27 8 by by IN cord-263469-2w26l80a 27 9 the the DT cord-263469-2w26l80a 27 10 cellular cellular JJ cord-263469-2w26l80a 27 11 subtilisin subtilisin NNS cord-263469-2w26l80a 27 12 - - HYPH cord-263469-2w26l80a 27 13 like like JJ cord-263469-2w26l80a 27 14 protease protease NN cord-263469-2w26l80a 27 15 furin furin NN cord-263469-2w26l80a 27 16 [ [ -LRB- cord-263469-2w26l80a 27 17 11 11 CD cord-263469-2w26l80a 27 18 , , , cord-263469-2w26l80a 27 19 10 10 CD cord-263469-2w26l80a 27 20 ] ] -RRB- cord-263469-2w26l80a 27 21 . . . cord-263469-2w26l80a 28 1 The the DT cord-263469-2w26l80a 28 2 amino amino NN cord-263469-2w26l80a 28 3 terminal terminal NN cord-263469-2w26l80a 28 4 product product NN cord-263469-2w26l80a 28 5 ( ( -LRB- cord-263469-2w26l80a 28 6 GP1 gp1 NN cord-263469-2w26l80a 28 7 , , , cord-263469-2w26l80a 28 8 Gn Gn NNP cord-263469-2w26l80a 28 9 , , , cord-263469-2w26l80a 28 10 gp41 gp41 NNP cord-263469-2w26l80a 28 11 ) ) -RRB- cord-263469-2w26l80a 28 12 has have VBZ cord-263469-2w26l80a 28 13 an an DT cord-263469-2w26l80a 28 14 apparent apparent JJ cord-263469-2w26l80a 28 15 molecular molecular JJ cord-263469-2w26l80a 28 16 mass mass NN cord-263469-2w26l80a 28 17 of of IN cord-263469-2w26l80a 28 18 41 41 CD cord-263469-2w26l80a 28 19 kDa kDa NNS cord-263469-2w26l80a 28 20 . . . cord-263469-2w26l80a 29 1 GP1 GP1 NNP cord-263469-2w26l80a 29 2 was be VBD cord-263469-2w26l80a 29 3 initially initially RB cord-263469-2w26l80a 29 4 difficult difficult JJ cord-263469-2w26l80a 29 5 to to TO cord-263469-2w26l80a 29 6 detect detect VB cord-263469-2w26l80a 29 7 in in IN cord-263469-2w26l80a 29 8 infected infected JJ cord-263469-2w26l80a 29 9 cells cell NNS cord-263469-2w26l80a 29 10 or or CC cord-263469-2w26l80a 29 11 virions virion NNS cord-263469-2w26l80a 29 12 due due IN cord-263469-2w26l80a 29 13 to to IN cord-263469-2w26l80a 29 14 its -PRON- PRP$ cord-263469-2w26l80a 29 15 high high JJ cord-263469-2w26l80a 29 16 glycan glycan NN cord-263469-2w26l80a 29 17 content content NN cord-263469-2w26l80a 29 18 , , , cord-263469-2w26l80a 29 19 which which WDT cord-263469-2w26l80a 29 20 shields shield VBZ cord-263469-2w26l80a 29 21 antigenic antigenic JJ cord-263469-2w26l80a 29 22 sites site NNS cord-263469-2w26l80a 29 23 from from IN cord-263469-2w26l80a 29 24 antibodies antibody NNS cord-263469-2w26l80a 29 25 . . . cord-263469-2w26l80a 30 1 However however RB cord-263469-2w26l80a 30 2 , , , cord-263469-2w26l80a 30 3 a a DT cord-263469-2w26l80a 30 4 peptide peptide NN cord-263469-2w26l80a 30 5 - - HYPH cord-263469-2w26l80a 30 6 generated generate VBN cord-263469-2w26l80a 30 7 antibody antibody NN cord-263469-2w26l80a 30 8 was be VBD cord-263469-2w26l80a 30 9 used use VBN cord-263469-2w26l80a 30 10 to to TO cord-263469-2w26l80a 30 11 demonstrate demonstrate VB cord-263469-2w26l80a 30 12 the the DT cord-263469-2w26l80a 30 13 presence presence NN cord-263469-2w26l80a 30 14 of of IN cord-263469-2w26l80a 30 15 GP1 gp1 NN cord-263469-2w26l80a 30 16 in in IN cord-263469-2w26l80a 30 17 virions virion NNS cord-263469-2w26l80a 30 18 and and CC cord-263469-2w26l80a 30 19 infected infected JJ cord-263469-2w26l80a 30 20 cells cell NNS cord-263469-2w26l80a 30 21 [ [ -LRB- cord-263469-2w26l80a 30 22 12 12 CD cord-263469-2w26l80a 30 23 ] ] -RRB- cord-263469-2w26l80a 30 24 . . . cord-263469-2w26l80a 31 1 The the DT cord-263469-2w26l80a 31 2 carboxyl carboxyl NN cord-263469-2w26l80a 31 3 terminal terminal NN cord-263469-2w26l80a 31 4 product product NN cord-263469-2w26l80a 31 5 , , , cord-263469-2w26l80a 31 6 molecular molecular JJ cord-263469-2w26l80a 31 7 mass mass NN cord-263469-2w26l80a 31 8 43 43 CD cord-263469-2w26l80a 31 9 kDa kDa NNPS cord-263469-2w26l80a 31 10 ( ( -LRB- cord-263469-2w26l80a 31 11 GP2 GP2 NNP cord-263469-2w26l80a 31 12 , , , cord-263469-2w26l80a 31 13 Gc Gc NNP cord-263469-2w26l80a 31 14 , , , cord-263469-2w26l80a 31 15 gp43 gp43 NNP cord-263469-2w26l80a 31 16 ) ) -RRB- cord-263469-2w26l80a 31 17 , , , cord-263469-2w26l80a 31 18 is be VBZ cord-263469-2w26l80a 31 19 less less RBR cord-263469-2w26l80a 31 20 heavily heavily RB cord-263469-2w26l80a 31 21 glycosylated glycosylated JJ cord-263469-2w26l80a 31 22 and and CC cord-263469-2w26l80a 31 23 readily readily RB cord-263469-2w26l80a 31 24 detected detect VBN cord-263469-2w26l80a 31 25 in in IN cord-263469-2w26l80a 31 26 infected infected JJ cord-263469-2w26l80a 31 27 cells cell NNS cord-263469-2w26l80a 31 28 and and CC cord-263469-2w26l80a 31 29 virions virion NNS cord-263469-2w26l80a 31 30 . . . cord-263469-2w26l80a 32 1 The the DT cord-263469-2w26l80a 32 2 uncleaved uncleaved JJ cord-263469-2w26l80a 32 3 product product NN cord-263469-2w26l80a 32 4 G g NN cord-263469-2w26l80a 32 5 accumulates accumulate VBZ cord-263469-2w26l80a 32 6 in in IN cord-263469-2w26l80a 32 7 the the DT cord-263469-2w26l80a 32 8 endoplasmic endoplasmic NN cord-263469-2w26l80a 32 9 reticulum reticulum NN cord-263469-2w26l80a 32 10 and and CC cord-263469-2w26l80a 32 11 perinuclear perinuclear NNP cord-263469-2w26l80a 32 12 region region NN cord-263469-2w26l80a 32 13 . . . cord-263469-2w26l80a 33 1 G g NN cord-263469-2w26l80a 33 2 is be VBZ cord-263469-2w26l80a 33 3 not not RB cord-263469-2w26l80a 33 4 detected detect VBN cord-263469-2w26l80a 33 5 on on IN cord-263469-2w26l80a 33 6 the the DT cord-263469-2w26l80a 33 7 plasma plasma NN cord-263469-2w26l80a 33 8 membrane membrane NN cord-263469-2w26l80a 33 9 , , , cord-263469-2w26l80a 33 10 whereas whereas IN cord-263469-2w26l80a 33 11 GP2 GP2 NNP cord-263469-2w26l80a 33 12 , , , cord-263469-2w26l80a 33 13 but but CC cord-263469-2w26l80a 33 14 not not RB cord-263469-2w26l80a 33 15 GP1 GP1 NNP cord-263469-2w26l80a 33 16 , , , cord-263469-2w26l80a 33 17 accumulates accumulate VBZ cord-263469-2w26l80a 33 18 at at IN cord-263469-2w26l80a 33 19 the the DT cord-263469-2w26l80a 33 20 cell cell NN cord-263469-2w26l80a 33 21 surface surface NN cord-263469-2w26l80a 33 22 [ [ -LRB- cord-263469-2w26l80a 33 23 10 10 CD cord-263469-2w26l80a 33 24 ] ] -RRB- cord-263469-2w26l80a 33 25 . . . cord-263469-2w26l80a 34 1 There there EX cord-263469-2w26l80a 34 2 are be VBP cord-263469-2w26l80a 34 3 conflicting conflict VBG cord-263469-2w26l80a 34 4 results result NNS cord-263469-2w26l80a 34 5 as as IN cord-263469-2w26l80a 34 6 to to IN cord-263469-2w26l80a 34 7 the the DT cord-263469-2w26l80a 34 8 presence presence NN cord-263469-2w26l80a 34 9 of of IN cord-263469-2w26l80a 34 10 uncleaved uncleaved JJ cord-263469-2w26l80a 34 11 G G NNP cord-263469-2w26l80a 34 12 in in IN cord-263469-2w26l80a 34 13 virions virion NNS cord-263469-2w26l80a 34 14 [ [ -LRB- cord-263469-2w26l80a 34 15 13 13 CD cord-263469-2w26l80a 34 16 , , , cord-263469-2w26l80a 34 17 9 9 CD cord-263469-2w26l80a 34 18 ] ] -RRB- cord-263469-2w26l80a 34 19 . . . cord-263469-2w26l80a 35 1 GP2 GP2 NNP cord-263469-2w26l80a 35 2 contains contain VBZ cord-263469-2w26l80a 35 3 several several JJ cord-263469-2w26l80a 35 4 hydrophobic hydrophobic JJ cord-263469-2w26l80a 35 5 sequences sequence NNS cord-263469-2w26l80a 35 6 , , , cord-263469-2w26l80a 35 7 and and CC cord-263469-2w26l80a 35 8 appears appear VBZ cord-263469-2w26l80a 35 9 capable capable JJ cord-263469-2w26l80a 35 10 of of IN cord-263469-2w26l80a 35 11 mediating mediate VBG cord-263469-2w26l80a 35 12 cell cell NN cord-263469-2w26l80a 35 13 : : : cord-263469-2w26l80a 35 14 cell cell NN cord-263469-2w26l80a 35 15 fusion fusion NN cord-263469-2w26l80a 35 16 in in IN cord-263469-2w26l80a 35 17 the the DT cord-263469-2w26l80a 35 18 absence absence NN cord-263469-2w26l80a 35 19 of of IN cord-263469-2w26l80a 35 20 other other JJ cord-263469-2w26l80a 35 21 BDV BDV NNP cord-263469-2w26l80a 35 22 surface surface NN cord-263469-2w26l80a 35 23 proteins protein NNS cord-263469-2w26l80a 35 24 [ [ -LRB- cord-263469-2w26l80a 35 25 10 10 CD cord-263469-2w26l80a 35 26 , , , cord-263469-2w26l80a 35 27 14 14 CD cord-263469-2w26l80a 35 28 ] ] -RRB- cord-263469-2w26l80a 35 29 . . . cord-263469-2w26l80a 36 1 GP1 GP1 NNP cord-263469-2w26l80a 36 2 linked link VBD cord-263469-2w26l80a 36 3 to to IN cord-263469-2w26l80a 36 4 the the DT cord-263469-2w26l80a 36 5 vesicular vesicular JJ cord-263469-2w26l80a 36 6 stomatitis stomatitis NN cord-263469-2w26l80a 36 7 virus virus NN cord-263469-2w26l80a 36 8 glycoprotein glycoprotein NN cord-263469-2w26l80a 36 9 transmembrane transmembrane NN cord-263469-2w26l80a 36 10 domain domain NN cord-263469-2w26l80a 36 11 ( ( -LRB- cord-263469-2w26l80a 36 12 VSV VSV NNP cord-263469-2w26l80a 36 13 G G NNP cord-263469-2w26l80a 36 14 TM TM NNP cord-263469-2w26l80a 36 15 ) ) -RRB- cord-263469-2w26l80a 36 16 domain domain NN cord-263469-2w26l80a 36 17 is be VBZ cord-263469-2w26l80a 36 18 sufficient sufficient JJ cord-263469-2w26l80a 36 19 , , , cord-263469-2w26l80a 36 20 in in IN cord-263469-2w26l80a 36 21 the the DT cord-263469-2w26l80a 36 22 absence absence NN cord-263469-2w26l80a 36 23 of of IN cord-263469-2w26l80a 36 24 GP2 GP2 NNP cord-263469-2w26l80a 36 25 , , , cord-263469-2w26l80a 36 26 for for IN cord-263469-2w26l80a 36 27 receptor receptor NN cord-263469-2w26l80a 36 28 recognition recognition NN cord-263469-2w26l80a 36 29 , , , cord-263469-2w26l80a 36 30 cell cell NN cord-263469-2w26l80a 36 31 fusion fusion NN cord-263469-2w26l80a 36 32 and and CC cord-263469-2w26l80a 36 33 entry entry NN cord-263469-2w26l80a 36 34 [ [ -LRB- cord-263469-2w26l80a 36 35 15 15 CD cord-263469-2w26l80a 36 36 ] ] -RRB- cord-263469-2w26l80a 36 37 . . . cord-263469-2w26l80a 37 1 The the DT cord-263469-2w26l80a 37 2 structures structure NNS cord-263469-2w26l80a 37 3 of of IN cord-263469-2w26l80a 37 4 the the DT cord-263469-2w26l80a 37 5 bornavirus bornavirus NNP cord-263469-2w26l80a 37 6 glycoproteins glycoprotein NNS cord-263469-2w26l80a 37 7 have have VBP cord-263469-2w26l80a 37 8 not not RB cord-263469-2w26l80a 37 9 been be VBN cord-263469-2w26l80a 37 10 determined determine VBN cord-263469-2w26l80a 37 11 , , , cord-263469-2w26l80a 37 12 and and CC cord-263469-2w26l80a 37 13 it -PRON- PRP cord-263469-2w26l80a 37 14 is be VBZ cord-263469-2w26l80a 37 15 unknown unknown JJ cord-263469-2w26l80a 37 16 whether whether IN cord-263469-2w26l80a 37 17 or or CC cord-263469-2w26l80a 37 18 not not RB cord-263469-2w26l80a 37 19 these these DT cord-263469-2w26l80a 37 20 proteins protein NNS cord-263469-2w26l80a 37 21 belong belong VBP cord-263469-2w26l80a 37 22 to to IN cord-263469-2w26l80a 37 23 any any DT cord-263469-2w26l80a 37 24 of of IN cord-263469-2w26l80a 37 25 the the DT cord-263469-2w26l80a 37 26 three three CD cord-263469-2w26l80a 37 27 known know VBN cord-263469-2w26l80a 37 28 classes class NNS cord-263469-2w26l80a 37 29 of of IN cord-263469-2w26l80a 37 30 proteins protein NNS cord-263469-2w26l80a 37 31 that that WDT cord-263469-2w26l80a 37 32 mediate mediate VBP cord-263469-2w26l80a 37 33 membrane membrane NN cord-263469-2w26l80a 37 34 fusion fusion NN cord-263469-2w26l80a 37 35 and and CC cord-263469-2w26l80a 37 36 entry entry NN cord-263469-2w26l80a 37 37 of of IN cord-263469-2w26l80a 37 38 enveloped envelop VBN cord-263469-2w26l80a 37 39 viruses virus NNS cord-263469-2w26l80a 37 40 . . . cord-263469-2w26l80a 38 1 Orthomyxoviruses Orthomyxoviruses NNP cord-263469-2w26l80a 39 1 ( ( -LRB- cord-263469-2w26l80a 39 2 excepting except VBG cord-263469-2w26l80a 39 3 members member NNS cord-263469-2w26l80a 39 4 of of IN cord-263469-2w26l80a 39 5 the the DT cord-263469-2w26l80a 39 6 Thogotovirus Thogotovirus NNP cord-263469-2w26l80a 39 7 genus genus NN cord-263469-2w26l80a 39 8 , , , cord-263469-2w26l80a 39 9 which which WDT cord-263469-2w26l80a 39 10 are be VBP cord-263469-2w26l80a 39 11 insect insect NN cord-263469-2w26l80a 39 12 pathogens pathogen NNS cord-263469-2w26l80a 39 13 ) ) -RRB- cord-263469-2w26l80a 39 14 , , , cord-263469-2w26l80a 39 15 retroviruses retrovirus NNS cord-263469-2w26l80a 39 16 , , , cord-263469-2w26l80a 39 17 paramyxoviruses paramyxovirus NNS cord-263469-2w26l80a 39 18 , , , cord-263469-2w26l80a 39 19 filoviruses filovirus NNS cord-263469-2w26l80a 39 20 , , , cord-263469-2w26l80a 39 21 arenaviruses arenavirus NNS cord-263469-2w26l80a 39 22 , , , cord-263469-2w26l80a 39 23 and and CC cord-263469-2w26l80a 39 24 coronaviruses coronaviruse NNS cord-263469-2w26l80a 39 25 encode encode VBP cord-263469-2w26l80a 39 26 class class NN cord-263469-2w26l80a 39 27 I -PRON- PRP cord-263469-2w26l80a 39 28 viral viral JJ cord-263469-2w26l80a 39 29 fusion fusion NN cord-263469-2w26l80a 39 30 proteins protein NNS cord-263469-2w26l80a 39 31 ( ( -LRB- cord-263469-2w26l80a 39 32 VFP VFP NNP cord-263469-2w26l80a 39 33 , , , cord-263469-2w26l80a 39 34 aka aka RB cord-263469-2w26l80a 39 35 class class NN cord-263469-2w26l80a 39 36 I -PRON- PRP cord-263469-2w26l80a 39 37 or or CC cord-263469-2w26l80a 39 38 α α NN cord-263469-2w26l80a 39 39 - - HYPH cord-263469-2w26l80a 39 40 penetrenes penetrenes NNP cord-263469-2w26l80a 39 41 ) ) -RRB- cord-263469-2w26l80a 39 42 . . . cord-263469-2w26l80a 40 1 Class class NN cord-263469-2w26l80a 40 2 I -PRON- PRP cord-263469-2w26l80a 40 3 VFP VFP NNP cord-263469-2w26l80a 40 4 contain contain VBP cord-263469-2w26l80a 40 5 a a DT cord-263469-2w26l80a 40 6 " " `` cord-263469-2w26l80a 40 7 fusion fusion NN cord-263469-2w26l80a 40 8 peptide peptide NN cord-263469-2w26l80a 40 9 , , , cord-263469-2w26l80a 40 10 " " '' cord-263469-2w26l80a 40 11 a a DT cord-263469-2w26l80a 40 12 cluster cluster NN cord-263469-2w26l80a 40 13 of of IN cord-263469-2w26l80a 40 14 hydrophobic hydrophobic JJ cord-263469-2w26l80a 40 15 and and CC cord-263469-2w26l80a 40 16 aromatic aromatic JJ cord-263469-2w26l80a 40 17 amino amino NN cord-263469-2w26l80a 40 18 acids acid NNS cord-263469-2w26l80a 40 19 located locate VBN cord-263469-2w26l80a 40 20 at at IN cord-263469-2w26l80a 40 21 or or CC cord-263469-2w26l80a 40 22 near near IN cord-263469-2w26l80a 40 23 the the DT cord-263469-2w26l80a 40 24 amino amino NN cord-263469-2w26l80a 40 25 terminus terminus NN cord-263469-2w26l80a 40 26 that that WDT cord-263469-2w26l80a 40 27 initially initially RB cord-263469-2w26l80a 40 28 interacts interact VBZ cord-263469-2w26l80a 40 29 with with IN cord-263469-2w26l80a 40 30 the the DT cord-263469-2w26l80a 40 31 target target NN cord-263469-2w26l80a 40 32 cell cell NN cord-263469-2w26l80a 40 33 membrane membrane NN cord-263469-2w26l80a 40 34 ( ( -LRB- cord-263469-2w26l80a 40 35 plasma plasma NN cord-263469-2w26l80a 40 36 membrane membrane NN cord-263469-2w26l80a 40 37 or or CC cord-263469-2w26l80a 40 38 vesicle vesicle NN cord-263469-2w26l80a 40 39 membrane membrane NN cord-263469-2w26l80a 40 40 ) ) -RRB- cord-263469-2w26l80a 40 41 [ [ -LRB- cord-263469-2w26l80a 40 42 16 16 CD cord-263469-2w26l80a 40 43 ] ] -RRB- cord-263469-2w26l80a 40 44 [ [ -LRB- cord-263469-2w26l80a 40 45 17 17 CD cord-263469-2w26l80a 40 46 ] ] -RRB- cord-263469-2w26l80a 40 47 [ [ -LRB- cord-263469-2w26l80a 40 48 18 18 CD cord-263469-2w26l80a 40 49 ] ] -RRB- cord-263469-2w26l80a 40 50 [ [ -LRB- cord-263469-2w26l80a 40 51 19 19 CD cord-263469-2w26l80a 40 52 ] ] -RRB- cord-263469-2w26l80a 40 53 [ [ -LRB- cord-263469-2w26l80a 40 54 20 20 CD cord-263469-2w26l80a 40 55 ] ] -RRB- cord-263469-2w26l80a 40 56 [ [ -LRB- cord-263469-2w26l80a 40 57 21 21 CD cord-263469-2w26l80a 40 58 ] ] -RRB- cord-263469-2w26l80a 40 59 [ [ -LRB- cord-263469-2w26l80a 40 60 22 22 CD cord-263469-2w26l80a 40 61 ] ] -RRB- cord-263469-2w26l80a 40 62 [ [ -LRB- cord-263469-2w26l80a 40 63 23 23 CD cord-263469-2w26l80a 40 64 ] ] -RRB- cord-263469-2w26l80a 40 65 . . . cord-263469-2w26l80a 41 1 Most Most JJS cord-263469-2w26l80a 41 2 class class NN cord-263469-2w26l80a 42 1 I -PRON- PRP cord-263469-2w26l80a 42 2 VFP VFP NNP cord-263469-2w26l80a 42 3 have have VBP cord-263469-2w26l80a 42 4 an an DT cord-263469-2w26l80a 42 5 aromatic aromatic JJ cord-263469-2w26l80a 42 6 amino amino NN cord-263469-2w26l80a 42 7 acid acid NN cord-263469-2w26l80a 42 8 ( ( -LRB- cord-263469-2w26l80a 42 9 aa aa NNP cord-263469-2w26l80a 42 10 ) ) -RRB- cord-263469-2w26l80a 42 11 rich rich JJ cord-263469-2w26l80a 42 12 pre pre NN cord-263469-2w26l80a 42 13 - - NN cord-263469-2w26l80a 42 14 membrane membrane JJ cord-263469-2w26l80a 42 15 domain domain NN cord-263469-2w26l80a 42 16 , , , cord-263469-2w26l80a 42 17 while while IN cord-263469-2w26l80a 42 18 all all DT cord-263469-2w26l80a 42 19 have have VBP cord-263469-2w26l80a 42 20 a a DT cord-263469-2w26l80a 42 21 carboxyl carboxyl NN cord-263469-2w26l80a 42 22 terminal terminal JJ cord-263469-2w26l80a 42 23 anchor anchor NN cord-263469-2w26l80a 42 24 . . . cord-263469-2w26l80a 43 1 The the DT cord-263469-2w26l80a 43 2 post post JJ cord-263469-2w26l80a 43 3 - - JJ cord-263469-2w26l80a 43 4 fusion fusion JJ cord-263469-2w26l80a 43 5 forms form NNS cord-263469-2w26l80a 43 6 of of IN cord-263469-2w26l80a 43 7 class class NN cord-263469-2w26l80a 43 8 I -PRON- PRP cord-263469-2w26l80a 43 9 viral viral JJ cord-263469-2w26l80a 43 10 fusion fusion NN cord-263469-2w26l80a 43 11 proteins protein NNS cord-263469-2w26l80a 43 12 have have VBP cord-263469-2w26l80a 43 13 an an DT cord-263469-2w26l80a 43 14 extended extend VBN cord-263469-2w26l80a 43 15 amino amino NN cord-263469-2w26l80a 43 16 terminal terminal NN cord-263469-2w26l80a 43 17 helix helix NN cord-263469-2w26l80a 43 18 ( ( -LRB- cord-263469-2w26l80a 43 19 N N NNP cord-263469-2w26l80a 43 20 - - HYPH cord-263469-2w26l80a 43 21 helix helix NN cord-263469-2w26l80a 43 22 , , , cord-263469-2w26l80a 43 23 HR1 HR1 NNP cord-263469-2w26l80a 43 24 ) ) -RRB- cord-263469-2w26l80a 43 25 , , , cord-263469-2w26l80a 43 26 and and CC cord-263469-2w26l80a 43 27 a a DT cord-263469-2w26l80a 43 28 carboxyl carboxyl NN cord-263469-2w26l80a 43 29 terminal terminal NN cord-263469-2w26l80a 43 30 helix helix NN cord-263469-2w26l80a 43 31 ( ( -LRB- cord-263469-2w26l80a 43 32 C c NN cord-263469-2w26l80a 43 33 - - HYPH cord-263469-2w26l80a 43 34 helix helix NNP cord-263469-2w26l80a 43 35 , , , cord-263469-2w26l80a 43 36 HR2 HR2 NNP cord-263469-2w26l80a 43 37 ) ) -RRB- cord-263469-2w26l80a 43 38 or or CC cord-263469-2w26l80a 43 39 " " `` cord-263469-2w26l80a 43 40 leash leash NN cord-263469-2w26l80a 43 41 domain domain NN cord-263469-2w26l80a 43 42 " " '' cord-263469-2w26l80a 43 43 that that WDT cord-263469-2w26l80a 43 44 mediate mediate VBP cord-263469-2w26l80a 43 45 trimerization trimerization NN cord-263469-2w26l80a 43 46 . . . cord-263469-2w26l80a 44 1 Members member NNS cord-263469-2w26l80a 44 2 of of IN cord-263469-2w26l80a 44 3 the the DT cord-263469-2w26l80a 44 4 Flavivirus Flavivirus NNP cord-263469-2w26l80a 44 5 genus genus NN cord-263469-2w26l80a 44 6 of of IN cord-263469-2w26l80a 44 7 the the DT cord-263469-2w26l80a 44 8 Flaviviridae Flaviviridae NNP cord-263469-2w26l80a 44 9 and and CC cord-263469-2w26l80a 44 10 the the DT cord-263469-2w26l80a 44 11 Alphavirus Alphavirus NNP cord-263469-2w26l80a 44 12 genus genus NN cord-263469-2w26l80a 44 13 of of IN cord-263469-2w26l80a 44 14 the the DT cord-263469-2w26l80a 44 15 Togaviridae Togaviridae NNP cord-263469-2w26l80a 44 16 encode encode VB cord-263469-2w26l80a 44 17 class class NN cord-263469-2w26l80a 44 18 II ii CD cord-263469-2w26l80a 44 19 viral viral JJ cord-263469-2w26l80a 44 20 fusion fusion NN cord-263469-2w26l80a 44 21 proteins protein NNS cord-263469-2w26l80a 44 22 ( ( -LRB- cord-263469-2w26l80a 44 23 class class NN cord-263469-2w26l80a 44 24 II II NNP cord-263469-2w26l80a 44 25 or or CC cord-263469-2w26l80a 44 26 β β NN cord-263469-2w26l80a 44 27 - - HYPH cord-263469-2w26l80a 44 28 penetrenes penetrenes NNP cord-263469-2w26l80a 44 29 ) ) -RRB- cord-263469-2w26l80a 44 30 possessing possess VBG cord-263469-2w26l80a 44 31 three three CD cord-263469-2w26l80a 44 32 domains domain NNS cord-263469-2w26l80a 44 33 ( ( -LRB- cord-263469-2w26l80a 44 34 I I NNP cord-263469-2w26l80a 44 35 - - HYPH cord-263469-2w26l80a 44 36 III III NNP cord-263469-2w26l80a 44 37 ) ) -RRB- cord-263469-2w26l80a 44 38 of of IN cord-263469-2w26l80a 44 39 mostly mostly RB cord-263469-2w26l80a 44 40 antiparallel antiparallel IN cord-263469-2w26l80a 44 41 β β NN cord-263469-2w26l80a 44 42 - - HYPH cord-263469-2w26l80a 44 43 sheets sheet NNS cord-263469-2w26l80a 44 44 , , , cord-263469-2w26l80a 44 45 a a DT cord-263469-2w26l80a 44 46 membrane membrane NN cord-263469-2w26l80a 44 47 proximal proximal VBG cord-263469-2w26l80a 44 48 α α NN cord-263469-2w26l80a 44 49 - - HYPH cord-263469-2w26l80a 44 50 helical helical JJ cord-263469-2w26l80a 44 51 stem stem NN cord-263469-2w26l80a 44 52 domain domain NN cord-263469-2w26l80a 44 53 and and CC cord-263469-2w26l80a 44 54 a a DT cord-263469-2w26l80a 44 55 carboxyl carboxyl NN cord-263469-2w26l80a 44 56 terminal terminal NN cord-263469-2w26l80a 44 57 anchor anchor NN cord-263469-2w26l80a 44 58 [ [ -LRB- cord-263469-2w26l80a 44 59 24 24 CD cord-263469-2w26l80a 44 60 ] ] -RRB- cord-263469-2w26l80a 44 61 [ [ -LRB- cord-263469-2w26l80a 44 62 25 25 CD cord-263469-2w26l80a 44 63 ] ] -RRB- cord-263469-2w26l80a 44 64 [ [ -LRB- cord-263469-2w26l80a 44 65 26 26 CD cord-263469-2w26l80a 44 66 ] ] -RRB- cord-263469-2w26l80a 44 67 . . . cord-263469-2w26l80a 45 1 The the DT cord-263469-2w26l80a 45 2 fusion fusion NN cord-263469-2w26l80a 45 3 loops loop NNS cord-263469-2w26l80a 45 4 of of IN cord-263469-2w26l80a 45 5 class class NN cord-263469-2w26l80a 45 6 II II NNP cord-263469-2w26l80a 45 7 VFP VFP NNP cord-263469-2w26l80a 45 8 are be VBP cord-263469-2w26l80a 45 9 internal internal JJ cord-263469-2w26l80a 45 10 and and CC cord-263469-2w26l80a 45 11 located locate VBN cord-263469-2w26l80a 45 12 in in IN cord-263469-2w26l80a 45 13 domain domain NN cord-263469-2w26l80a 45 14 II II NNP cord-263469-2w26l80a 45 15 , , , cord-263469-2w26l80a 45 16 the the DT cord-263469-2w26l80a 45 17 fusion fusion NN cord-263469-2w26l80a 45 18 domain domain NN cord-263469-2w26l80a 45 19 . . . cord-263469-2w26l80a 46 1 Hepaciviruses Hepaciviruses NNP cord-263469-2w26l80a 46 2 and and CC cord-263469-2w26l80a 46 3 Pestiviruses Pestiviruses NNP cord-263469-2w26l80a 46 4 , , , cord-263469-2w26l80a 46 5 the the DT cord-263469-2w26l80a 46 6 two two CD cord-263469-2w26l80a 46 7 other other JJ cord-263469-2w26l80a 46 8 genuses genus NNS cord-263469-2w26l80a 46 9 in in IN cord-263469-2w26l80a 46 10 the the DT cord-263469-2w26l80a 46 11 Flaviviridae Flaviviridae NNP cord-263469-2w26l80a 46 12 , , , cord-263469-2w26l80a 46 13 appear appear VBP cord-263469-2w26l80a 46 14 to to TO cord-263469-2w26l80a 46 15 encode encode VB cord-263469-2w26l80a 46 16 truncated truncated JJ cord-263469-2w26l80a 46 17 class class NN cord-263469-2w26l80a 46 18 II II NNP cord-263469-2w26l80a 46 19 VFP VFP NNP cord-263469-2w26l80a 46 20 [ [ -LRB- cord-263469-2w26l80a 46 21 27 27 CD cord-263469-2w26l80a 46 22 ] ] -RRB- cord-263469-2w26l80a 46 23 . . . cord-263469-2w26l80a 47 1 Proteomics Proteomics NNP cord-263469-2w26l80a 47 2 computational computational JJ cord-263469-2w26l80a 47 3 analyses analysis NNS cord-263469-2w26l80a 47 4 and and CC cord-263469-2w26l80a 47 5 other other JJ cord-263469-2w26l80a 47 6 studies study NNS cord-263469-2w26l80a 47 7 suggest suggest VBP cord-263469-2w26l80a 47 8 that that IN cord-263469-2w26l80a 47 9 the the DT cord-263469-2w26l80a 47 10 carboxyl carboxyl NN cord-263469-2w26l80a 47 11 terminal terminal NN cord-263469-2w26l80a 47 12 glycoproteins glycoprotein NNS cord-263469-2w26l80a 47 13 ( ( -LRB- cord-263469-2w26l80a 47 14 Gc Gc NNP cord-263469-2w26l80a 47 15 ) ) -RRB- cord-263469-2w26l80a 47 16 of of IN cord-263469-2w26l80a 47 17 bunyaviruses bunyaviruses NNP cord-263469-2w26l80a 47 18 , , , cord-263469-2w26l80a 47 19 tenuiviruses tenuiviruses NNP cord-263469-2w26l80a 47 20 and and CC cord-263469-2w26l80a 47 21 Caenorhabditis Caenorhabditis NNP cord-263469-2w26l80a 47 22 elegans elegan NNS cord-263469-2w26l80a 47 23 retroviruses retrovirus NNS cord-263469-2w26l80a 47 24 , , , cord-263469-2w26l80a 47 25 are be VBP cord-263469-2w26l80a 47 26 class class NN cord-263469-2w26l80a 47 27 II II NNP cord-263469-2w26l80a 47 28 VFP VFP NNP cord-263469-2w26l80a 47 29 [ [ -LRB- cord-263469-2w26l80a 47 30 28 28 CD cord-263469-2w26l80a 47 31 , , , cord-263469-2w26l80a 47 32 29 29 CD cord-263469-2w26l80a 47 33 ] ] -RRB- cord-263469-2w26l80a 47 34 . . . cord-263469-2w26l80a 48 1 The the DT cord-263469-2w26l80a 48 2 third third JJ cord-263469-2w26l80a 48 3 class class NN cord-263469-2w26l80a 48 4 of of IN cord-263469-2w26l80a 48 5 VFP VFP NNP cord-263469-2w26l80a 48 6 ( ( -LRB- cord-263469-2w26l80a 48 7 class class NN cord-263469-2w26l80a 48 8 III III NNP cord-263469-2w26l80a 48 9 or or CC cord-263469-2w26l80a 48 10 γ γ NN cord-263469-2w26l80a 48 11 - - HYPH cord-263469-2w26l80a 48 12 penetrenes penetrenes NNP cord-263469-2w26l80a 48 13 ) ) -RRB- cord-263469-2w26l80a 48 14 is be VBZ cord-263469-2w26l80a 48 15 represented represent VBN cord-263469-2w26l80a 48 16 by by IN cord-263469-2w26l80a 48 17 glycoprotein glycoprotein NN cord-263469-2w26l80a 48 18 ( ( -LRB- cord-263469-2w26l80a 48 19 G G NNP cord-263469-2w26l80a 48 20 ) ) -RRB- cord-263469-2w26l80a 48 21 of of IN cord-263469-2w26l80a 48 22 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 48 23 and and CC cord-263469-2w26l80a 48 24 glycoprotein glycoprotein NN cord-263469-2w26l80a 48 25 B B NNP cord-263469-2w26l80a 48 26 ( ( -LRB- cord-263469-2w26l80a 48 27 gB gB NNP cord-263469-2w26l80a 48 28 ) ) -RRB- cord-263469-2w26l80a 48 29 of of IN cord-263469-2w26l80a 48 30 herpesviruses herpesviruses NNP cord-263469-2w26l80a 48 31 . . . cord-263469-2w26l80a 49 1 Class class NN cord-263469-2w26l80a 49 2 III III NNP cord-263469-2w26l80a 49 3 VFP VFP NNP cord-263469-2w26l80a 49 4 contain contain VBP cord-263469-2w26l80a 49 5 a a DT cord-263469-2w26l80a 49 6 fusion fusion NN cord-263469-2w26l80a 49 7 domain domain NN cord-263469-2w26l80a 49 8 , , , cord-263469-2w26l80a 49 9 which which WDT cord-263469-2w26l80a 49 10 is be VBZ cord-263469-2w26l80a 49 11 similar similar JJ cord-263469-2w26l80a 49 12 structurally structurally RB cord-263469-2w26l80a 49 13 to to IN cord-263469-2w26l80a 49 14 the the DT cord-263469-2w26l80a 49 15 fusion fusion NN cord-263469-2w26l80a 49 16 domains domain NNS cord-263469-2w26l80a 49 17 of of IN cord-263469-2w26l80a 49 18 class class NN cord-263469-2w26l80a 49 19 II II NNP cord-263469-2w26l80a 49 20 VFP VFP NNP cord-263469-2w26l80a 49 21 , , , cord-263469-2w26l80a 49 22 other other JJ cord-263469-2w26l80a 49 23 β β NN cord-263469-2w26l80a 49 24 - - HYPH cord-263469-2w26l80a 49 25 sheet sheet NN cord-263469-2w26l80a 49 26 domains domain NNS cord-263469-2w26l80a 49 27 , , , cord-263469-2w26l80a 49 28 an an DT cord-263469-2w26l80a 49 29 extended extended JJ cord-263469-2w26l80a 49 30 α α NN cord-263469-2w26l80a 49 31 - - HYPH cord-263469-2w26l80a 49 32 helical helical JJ cord-263469-2w26l80a 49 33 domain domain NN cord-263469-2w26l80a 49 34 in in IN cord-263469-2w26l80a 49 35 the the DT cord-263469-2w26l80a 49 36 post post JJ cord-263469-2w26l80a 49 37 - - JJ cord-263469-2w26l80a 49 38 fusion fusion JJ cord-263469-2w26l80a 49 39 form form NN cord-263469-2w26l80a 49 40 , , , cord-263469-2w26l80a 49 41 a a DT cord-263469-2w26l80a 49 42 membrane membrane NN cord-263469-2w26l80a 49 43 proximal proximal JJ cord-263469-2w26l80a 49 44 stem stem NN cord-263469-2w26l80a 49 45 and and CC cord-263469-2w26l80a 49 46 a a DT cord-263469-2w26l80a 49 47 carboxyl carboxyl NN cord-263469-2w26l80a 49 48 terminal terminal JJ cord-263469-2w26l80a 49 49 anchor anchor NN cord-263469-2w26l80a 49 50 [ [ -LRB- cord-263469-2w26l80a 49 51 30 30 CD cord-263469-2w26l80a 49 52 ] ] -RRB- cord-263469-2w26l80a 50 1 [ [ -LRB- cord-263469-2w26l80a 50 2 31 31 CD cord-263469-2w26l80a 50 3 ] ] -RRB- cord-263469-2w26l80a 50 4 [ [ -LRB- cord-263469-2w26l80a 50 5 32 32 CD cord-263469-2w26l80a 50 6 ] ] -RRB- cord-263469-2w26l80a 50 7 . . . cord-263469-2w26l80a 51 1 The the DT cord-263469-2w26l80a 51 2 extended extended JJ cord-263469-2w26l80a 51 3 α α NN cord-263469-2w26l80a 51 4 - - HYPH cord-263469-2w26l80a 51 5 helices helix NNS cord-263469-2w26l80a 51 6 in in IN cord-263469-2w26l80a 51 7 the the DT cord-263469-2w26l80a 51 8 post post JJ cord-263469-2w26l80a 51 9 - - JJ cord-263469-2w26l80a 51 10 fusion fusion JJ cord-263469-2w26l80a 51 11 forms form NNS cord-263469-2w26l80a 51 12 of of IN cord-263469-2w26l80a 51 13 rhabdovirus rhabdovirus NNP cord-263469-2w26l80a 51 14 G G NNP cord-263469-2w26l80a 51 15 and and CC cord-263469-2w26l80a 51 16 herpesvirus herpesvirus NN cord-263469-2w26l80a 51 17 gB gB NNP cord-263469-2w26l80a 51 18 are be VBP cord-263469-2w26l80a 51 19 involved involve VBN cord-263469-2w26l80a 51 20 in in IN cord-263469-2w26l80a 51 21 trimerization trimerization NN cord-263469-2w26l80a 51 22 , , , cord-263469-2w26l80a 51 23 a a DT cord-263469-2w26l80a 51 24 similar similar JJ cord-263469-2w26l80a 51 25 function function NN cord-263469-2w26l80a 51 26 served serve VBN cord-263469-2w26l80a 51 27 by by IN cord-263469-2w26l80a 51 28 the the DT cord-263469-2w26l80a 51 29 long long JJ cord-263469-2w26l80a 51 30 α α NN cord-263469-2w26l80a 51 31 - - HYPH cord-263469-2w26l80a 51 32 helices helix NNS cord-263469-2w26l80a 51 33 in in IN cord-263469-2w26l80a 51 34 the the DT cord-263469-2w26l80a 51 35 post post JJ cord-263469-2w26l80a 51 36 - - JJ cord-263469-2w26l80a 51 37 fusion fusion JJ cord-263469-2w26l80a 51 38 structures structure NNS cord-263469-2w26l80a 51 39 of of IN cord-263469-2w26l80a 51 40 class class NN cord-263469-2w26l80a 51 41 I -PRON- PRP cord-263469-2w26l80a 51 42 VFP VFP NNP cord-263469-2w26l80a 51 43 . . . cord-263469-2w26l80a 52 1 Our -PRON- PRP$ cord-263469-2w26l80a 52 2 prior prior JJ cord-263469-2w26l80a 52 3 proteomics proteomic NNS cord-263469-2w26l80a 52 4 computational computational JJ cord-263469-2w26l80a 52 5 analyses analysis NNS cord-263469-2w26l80a 52 6 suggested suggest VBD cord-263469-2w26l80a 52 7 that that IN cord-263469-2w26l80a 52 8 the the DT cord-263469-2w26l80a 52 9 fusion fusion NN cord-263469-2w26l80a 52 10 proteins protein NNS cord-263469-2w26l80a 52 11 of of IN cord-263469-2w26l80a 52 12 group group NN cord-263469-2w26l80a 52 13 I -PRON- PRP cord-263469-2w26l80a 52 14 nucleopolyhedroviruses nucleopolyhedroviruse VBZ cord-263469-2w26l80a 52 15 ( ( -LRB- cord-263469-2w26l80a 52 16 NPV NPV NNP cord-263469-2w26l80a 52 17 ) ) -RRB- cord-263469-2w26l80a 52 18 of of IN cord-263469-2w26l80a 52 19 the the DT cord-263469-2w26l80a 52 20 Baculoviridae Baculoviridae NNP cord-263469-2w26l80a 52 21 and and CC cord-263469-2w26l80a 52 22 members member NNS cord-263469-2w26l80a 52 23 of of IN cord-263469-2w26l80a 52 24 the the DT cord-263469-2w26l80a 52 25 Thogotovirus Thogotovirus NNP cord-263469-2w26l80a 52 26 genus genus NN cord-263469-2w26l80a 52 27 of of IN cord-263469-2w26l80a 52 28 the the DT cord-263469-2w26l80a 52 29 Orthomyxoviridae Orthomyxoviridae NNP cord-263469-2w26l80a 52 30 , , , cord-263469-2w26l80a 52 31 which which WDT cord-263469-2w26l80a 52 32 together together RB cord-263469-2w26l80a 52 33 form form VBP cord-263469-2w26l80a 52 34 the the DT cord-263469-2w26l80a 52 35 GP64 GP64 NNP cord-263469-2w26l80a 52 36 superfamily superfamily NN cord-263469-2w26l80a 52 37 , , , cord-263469-2w26l80a 52 38 are be VBP cord-263469-2w26l80a 52 39 also also RB cord-263469-2w26l80a 52 40 class class NN cord-263469-2w26l80a 52 41 III iii NN cord-263469-2w26l80a 52 42 VFP VFP NNP cord-263469-2w26l80a 52 43 [ [ -LRB- cord-263469-2w26l80a 52 44 33 33 CD cord-263469-2w26l80a 52 45 ] ] -RRB- cord-263469-2w26l80a 52 46 . . . cord-263469-2w26l80a 53 1 A a DT cord-263469-2w26l80a 53 2 recent recent JJ cord-263469-2w26l80a 53 3 Xray Xray NNP cord-263469-2w26l80a 53 4 crystallographic crystallographic JJ cord-263469-2w26l80a 53 5 study study NN cord-263469-2w26l80a 53 6 , , , cord-263469-2w26l80a 53 7 published publish VBN cord-263469-2w26l80a 53 8 after after IN cord-263469-2w26l80a 53 9 our -PRON- PRP$ cord-263469-2w26l80a 53 10 prior prior JJ cord-263469-2w26l80a 53 11 manuscript manuscript NN cord-263469-2w26l80a 53 12 , , , cord-263469-2w26l80a 53 13 confirmed confirm VBD cord-263469-2w26l80a 53 14 that that IN cord-263469-2w26l80a 53 15 GP64 GP64 NNP cord-263469-2w26l80a 53 16 superfamily superfamily NN cord-263469-2w26l80a 53 17 members member NNS cord-263469-2w26l80a 53 18 are be VBP cord-263469-2w26l80a 53 19 class class NN cord-263469-2w26l80a 53 20 III iii CD cord-263469-2w26l80a 53 21 VFP VFP NNP cord-263469-2w26l80a 53 22 [ [ -LRB- cord-263469-2w26l80a 53 23 34 34 CD cord-263469-2w26l80a 53 24 ] ] -RRB- cord-263469-2w26l80a 53 25 . . . cord-263469-2w26l80a 54 1 Here here RB cord-263469-2w26l80a 54 2 , , , cord-263469-2w26l80a 54 3 proteomics proteomic NNS cord-263469-2w26l80a 54 4 computational computational JJ cord-263469-2w26l80a 54 5 analyses analysis NNS cord-263469-2w26l80a 54 6 are be VBP cord-263469-2w26l80a 54 7 presented present VBN cord-263469-2w26l80a 54 8 suggesting suggest VBG cord-263469-2w26l80a 54 9 that that IN cord-263469-2w26l80a 54 10 bornavirus bornavirus NNP cord-263469-2w26l80a 54 11 G G NNP cord-263469-2w26l80a 54 12 are be VBP cord-263469-2w26l80a 54 13 class class NN cord-263469-2w26l80a 54 14 III iii NN cord-263469-2w26l80a 54 15 VFP VFP NNP cord-263469-2w26l80a 54 16 . . . cord-263469-2w26l80a 55 1 Sequence sequence NN cord-263469-2w26l80a 55 2 and and CC cord-263469-2w26l80a 55 3 structural structural JJ cord-263469-2w26l80a 55 4 comparisons comparison NNS cord-263469-2w26l80a 55 5 were be VBD cord-263469-2w26l80a 55 6 performed perform VBN cord-263469-2w26l80a 55 7 for for IN cord-263469-2w26l80a 55 8 Borna Borna NNP cord-263469-2w26l80a 55 9 disease disease NN cord-263469-2w26l80a 55 10 virus virus NN cord-263469-2w26l80a 55 11 strain strain NN cord-263469-2w26l80a 55 12 V V NNP cord-263469-2w26l80a 55 13 glycoprotein glycoprotein NN cord-263469-2w26l80a 55 14 isolated isolate VBN cord-263469-2w26l80a 55 15 from from IN cord-263469-2w26l80a 55 16 a a DT cord-263469-2w26l80a 55 17 horse horse NN cord-263469-2w26l80a 55 18 ( ( -LRB- cord-263469-2w26l80a 55 19 accession accession NN cord-263469-2w26l80a 55 20 number number NN cord-263469-2w26l80a 55 21 NP042023 NP042023 NNP cord-263469-2w26l80a 55 22 ) ) -RRB- cord-263469-2w26l80a 55 23 . . . cord-263469-2w26l80a 56 1 Additional additional JJ cord-263469-2w26l80a 56 2 bornavirus bornavirus NN cord-263469-2w26l80a 56 3 G g NN cord-263469-2w26l80a 56 4 sequences sequence NNS cord-263469-2w26l80a 56 5 used use VBN cord-263469-2w26l80a 56 6 in in IN cord-263469-2w26l80a 56 7 the the DT cord-263469-2w26l80a 56 8 analyses analysis NNS cord-263469-2w26l80a 56 9 included include VBN cord-263469-2w26l80a 56 10 ABH03174 ABH03174 NNP cord-263469-2w26l80a 56 11 , , , cord-263469-2w26l80a 56 12 CAC70658 cac70658 NN cord-263469-2w26l80a 56 13 ( ( -LRB- cord-263469-2w26l80a 56 14 horse horse NN cord-263469-2w26l80a 56 15 ) ) -RRB- cord-263469-2w26l80a 56 16 , , , cord-263469-2w26l80a 56 17 AAL49985 AAL49985 NNP cord-263469-2w26l80a 56 18 ( ( -LRB- cord-263469-2w26l80a 56 19 sheep sheep NN cord-263469-2w26l80a 56 20 ) ) -RRB- cord-263469-2w26l80a 56 21 , , , cord-263469-2w26l80a 56 22 ABH03169 ABH03169 NNP cord-263469-2w26l80a 56 23 ( ( -LRB- cord-263469-2w26l80a 56 24 rabbit rabbit NN cord-263469-2w26l80a 56 25 ) ) -RRB- cord-263469-2w26l80a 56 26 , , . cord-263469-2w26l80a 57 1 ACG59352 ACG59352 NNP cord-263469-2w26l80a 57 2 ( ( -LRB- cord-263469-2w26l80a 57 3 avian avian NNP cord-263469-2w26l80a 57 4 -Aratinga -Aratinga NNP cord-263469-2w26l80a 57 5 solstitialis solstitialis NNP cord-263469-2w26l80a 57 6 ) ) -RRB- cord-263469-2w26l80a 57 7 , , , cord-263469-2w26l80a 57 8 and and CC cord-263469-2w26l80a 57 9 AAA91195 AAA91195 NNP cord-263469-2w26l80a 57 10 ( ( -LRB- cord-263469-2w26l80a 57 11 human human NN cord-263469-2w26l80a 57 12 ) ) -RRB- cord-263469-2w26l80a 57 13 . . . cord-263469-2w26l80a 58 1 We -PRON- PRP cord-263469-2w26l80a 58 2 also also RB cord-263469-2w26l80a 58 3 made make VBD cord-263469-2w26l80a 58 4 comparisons comparison NNS cord-263469-2w26l80a 58 5 of of IN cord-263469-2w26l80a 58 6 bornavirus bornavirus NNP cord-263469-2w26l80a 58 7 G G NNP cord-263469-2w26l80a 58 8 with with IN cord-263469-2w26l80a 58 9 Thogato Thogato NNP cord-263469-2w26l80a 58 10 virus virus NN cord-263469-2w26l80a 58 11 strain strain VBP cord-263469-2w26l80a 58 12 SiAr SiAr NNP cord-263469-2w26l80a 58 13 126 126 CD cord-263469-2w26l80a 58 14 envelope envelope NN cord-263469-2w26l80a 58 15 glycoprotein glycoprotein NN cord-263469-2w26l80a 58 16 precursor precursor NN cord-263469-2w26l80a 58 17 ( ( -LRB- cord-263469-2w26l80a 58 18 P28977 P28977 NNP cord-263469-2w26l80a 58 19 ) ) -RRB- cord-263469-2w26l80a 58 20 , , , cord-263469-2w26l80a 58 21 the the DT cord-263469-2w26l80a 58 22 Autographa Autographa NNP cord-263469-2w26l80a 58 23 california california NNP cord-263469-2w26l80a 58 24 multiple multiple JJ cord-263469-2w26l80a 58 25 nucleopolyhedrovirus nucleopolyhedrovirus JJ cord-263469-2w26l80a 58 26 GP64 GP64 NNP cord-263469-2w26l80a 58 27 superfamily superfamily NN cord-263469-2w26l80a 58 28 protein protein NN cord-263469-2w26l80a 58 29 ( ( -LRB- cord-263469-2w26l80a 58 30 P17501 P17501 NNP cord-263469-2w26l80a 58 31 ) ) -RRB- cord-263469-2w26l80a 58 32 and and CC cord-263469-2w26l80a 58 33 other other JJ cord-263469-2w26l80a 58 34 GP64 GP64 NNP cord-263469-2w26l80a 58 35 superfamily superfamily NN cord-263469-2w26l80a 58 36 members member NNS cord-263469-2w26l80a 58 37 . . . cord-263469-2w26l80a 59 1 Representatives representative NNS cord-263469-2w26l80a 59 2 of of IN cord-263469-2w26l80a 59 3 G G NNP cord-263469-2w26l80a 59 4 from from IN cord-263469-2w26l80a 59 5 six six CD cord-263469-2w26l80a 59 6 genera genus NNS cord-263469-2w26l80a 59 7 of of IN cord-263469-2w26l80a 59 8 the the DT cord-263469-2w26l80a 59 9 Rhabdoviridae Rhabdoviridae NNP cord-263469-2w26l80a 59 10 were be VBD cord-263469-2w26l80a 59 11 also also RB cord-263469-2w26l80a 59 12 used use VBN cord-263469-2w26l80a 59 13 for for IN cord-263469-2w26l80a 59 14 sequence sequence NN cord-263469-2w26l80a 59 15 and and CC cord-263469-2w26l80a 59 16 structural structural JJ cord-263469-2w26l80a 59 17 comparisons comparison NNS cord-263469-2w26l80a 59 18 : : : cord-263469-2w26l80a 60 1 Vesiculovirus Vesiculovirus NNP cord-263469-2w26l80a 60 2 : : : cord-263469-2w26l80a 60 3 VSV VSV NNP cord-263469-2w26l80a 60 4 strain strain VB cord-263469-2w26l80a 60 5 Indiana Indiana NNP cord-263469-2w26l80a 60 6 ( ( -LRB- cord-263469-2w26l80a 60 7 AAA48370 AAA48370 NNP cord-263469-2w26l80a 60 8 ) ) -RRB- cord-263469-2w26l80a 60 9 ; ; : cord-263469-2w26l80a 61 1 Lyssavirus Lyssavirus NNP cord-263469-2w26l80a 61 2 : : : cord-263469-2w26l80a 61 3 rabiesvirus rabiesvirus NNP cord-263469-2w26l80a 61 4 strain strain NNP cord-263469-2w26l80a 61 5 street street NNP cord-263469-2w26l80a 61 6 ( ( -LRB- cord-263469-2w26l80a 61 7 AAA47211 AAA47211 NNP cord-263469-2w26l80a 61 8 ) ) -RRB- cord-263469-2w26l80a 61 9 ; ; : cord-263469-2w26l80a 61 10 Ephemerovirus Ephemerovirus NNP cord-263469-2w26l80a 61 11 : : : cord-263469-2w26l80a 61 12 bovine bovine JJ cord-263469-2w26l80a 61 13 ephemeral ephemeral JJ cord-263469-2w26l80a 61 14 fever fever NN cord-263469-2w26l80a 61 15 virus virus NN cord-263469-2w26l80a 61 16 structural structural JJ cord-263469-2w26l80a 61 17 G g NN cord-263469-2w26l80a 61 18 ( ( -LRB- cord-263469-2w26l80a 61 19 P32595 P32595 NNP cord-263469-2w26l80a 61 20 ) ) -RRB- cord-263469-2w26l80a 61 21 and and CC cord-263469-2w26l80a 61 22 nonstructural nonstructural JJ cord-263469-2w26l80a 61 23 G(P32596 G(P32596 NNP cord-263469-2w26l80a 61 24 ) ) -RRB- cord-263469-2w26l80a 61 25 ; ; : cord-263469-2w26l80a 61 26 Novirhabdovirus Novirhabdovirus NNP cord-263469-2w26l80a 61 27 : : : cord-263469-2w26l80a 61 28 infectious infectious JJ cord-263469-2w26l80a 61 29 hematopoietic hematopoietic JJ cord-263469-2w26l80a 61 30 necrosis necrosis NN cord-263469-2w26l80a 61 31 virus virus NN cord-263469-2w26l80a 61 32 ( ( -LRB- cord-263469-2w26l80a 61 33 CAA61498 CAA61498 NNP cord-263469-2w26l80a 61 34 ) ) -RRB- cord-263469-2w26l80a 61 35 ; ; : cord-263469-2w26l80a 61 36 Cytorhabdovirus Cytorhabdovirus NNP cord-263469-2w26l80a 61 37 : : : cord-263469-2w26l80a 61 38 lettuce lettuce NN cord-263469-2w26l80a 61 39 necrosis necrosis NN cord-263469-2w26l80a 61 40 yellows yellow NNS cord-263469-2w26l80a 61 41 virus virus NN cord-263469-2w26l80a 61 42 glycoprotein glycoprotein NN cord-263469-2w26l80a 61 43 ( ( -LRB- cord-263469-2w26l80a 61 44 LYP425091 LYP425091 NNP cord-263469-2w26l80a 61 45 ) ) -RRB- cord-263469-2w26l80a 61 46 ; ; : cord-263469-2w26l80a 61 47 Nucleorhabdovirus Nucleorhabdovirus NNP cord-263469-2w26l80a 61 48 : : : cord-263469-2w26l80a 61 49 rice rice NNP cord-263469-2w26l80a 61 50 yellow yellow JJ cord-263469-2w26l80a 61 51 stunt stunt NN cord-263469-2w26l80a 61 52 virus virus NN cord-263469-2w26l80a 61 53 ( ( -LRB- cord-263469-2w26l80a 61 54 AB011257 ab011257 NN cord-263469-2w26l80a 61 55 ) ) -RRB- cord-263469-2w26l80a 61 56 and and CC cord-263469-2w26l80a 61 57 an an DT cord-263469-2w26l80a 61 58 unclassified unclassified JJ cord-263469-2w26l80a 61 59 rhabdovirus rhabdovirus NN cord-263469-2w26l80a 61 60 : : : cord-263469-2w26l80a 61 61 Taastrup Taastrup NNP cord-263469-2w26l80a 61 62 virus virus NN cord-263469-2w26l80a 61 63 ( ( -LRB- cord-263469-2w26l80a 61 64 AY423355 ay423355 NN cord-263469-2w26l80a 61 65 ) ) -RRB- cord-263469-2w26l80a 61 66 . . . cord-263469-2w26l80a 62 1 We -PRON- PRP cord-263469-2w26l80a 62 2 also also RB cord-263469-2w26l80a 62 3 compared compare VBD cord-263469-2w26l80a 62 4 bornavirus bornavirus NNP cord-263469-2w26l80a 62 5 G G NNP cord-263469-2w26l80a 62 6 to to IN cord-263469-2w26l80a 62 7 VFP VFP NNP cord-263469-2w26l80a 62 8 of of IN cord-263469-2w26l80a 62 9 representative representative JJ cord-263469-2w26l80a 62 10 members member NNS cord-263469-2w26l80a 62 11 of of IN cord-263469-2w26l80a 62 12 the the DT cord-263469-2w26l80a 62 13 Herpesviridae Herpesviridae NNP cord-263469-2w26l80a 62 14 , , , cord-263469-2w26l80a 62 15 Flaviviridae Flaviviridae NNP cord-263469-2w26l80a 62 16 , , , cord-263469-2w26l80a 62 17 Togaviridae Togaviridae NNP cord-263469-2w26l80a 62 18 , , , cord-263469-2w26l80a 62 19 and and CC cord-263469-2w26l80a 62 20 Bunyaviridae Bunyaviridae NNP cord-263469-2w26l80a 62 21 . . . cord-263469-2w26l80a 63 1 Methods method NNS cord-263469-2w26l80a 63 2 developed develop VBN cord-263469-2w26l80a 63 3 by by IN cord-263469-2w26l80a 63 4 William William NNP cord-263469-2w26l80a 63 5 Gallaher Gallaher NNP cord-263469-2w26l80a 63 6 and and CC cord-263469-2w26l80a 63 7 coworkers coworker NNS cord-263469-2w26l80a 63 8 to to TO cord-263469-2w26l80a 63 9 derive derive VB cord-263469-2w26l80a 63 10 models model NNS cord-263469-2w26l80a 63 11 of of IN cord-263469-2w26l80a 63 12 VFP VFP NNP cord-263469-2w26l80a 63 13 have have VBP cord-263469-2w26l80a 63 14 been be VBN cord-263469-2w26l80a 63 15 described describe VBN cord-263469-2w26l80a 63 16 previously previously RB cord-263469-2w26l80a 63 17 [ [ -LRB- cord-263469-2w26l80a 63 18 22 22 CD cord-263469-2w26l80a 63 19 , , , cord-263469-2w26l80a 63 20 18 18 CD cord-263469-2w26l80a 63 21 , , , cord-263469-2w26l80a 63 22 17 17 CD cord-263469-2w26l80a 63 23 , , , cord-263469-2w26l80a 63 24 20 20 CD cord-263469-2w26l80a 63 25 ] ] -RRB- cord-263469-2w26l80a 63 26 . . . cord-263469-2w26l80a 64 1 William William NNP cord-263469-2w26l80a 64 2 Pearson Pearson NNP cord-263469-2w26l80a 64 3 's 's POS cord-263469-2w26l80a 64 4 LALIGN LALIGN NNP cord-263469-2w26l80a 64 5 program program NN cord-263469-2w26l80a 64 6 http:/ http:/ NN cord-263469-2w26l80a 64 7 /www.ch.embnet.org /www.ch.embnet.org NNP cord-263469-2w26l80a 64 8 / / SYM cord-263469-2w26l80a 64 9 software software NN cord-263469-2w26l80a 64 10 / / SYM cord-263469-2w26l80a 64 11 LALIGN_form.html LALIGN_form.html NNP cord-263469-2w26l80a 64 12 , , , cord-263469-2w26l80a 64 13 which which WDT cord-263469-2w26l80a 64 14 implements implement VBZ cord-263469-2w26l80a 64 15 a a DT cord-263469-2w26l80a 64 16 linear linear JJ cord-263469-2w26l80a 64 17 - - HYPH cord-263469-2w26l80a 64 18 space space NN cord-263469-2w26l80a 64 19 local local JJ cord-263469-2w26l80a 64 20 similarity similarity NN cord-263469-2w26l80a 64 21 algorithm algorithm NN cord-263469-2w26l80a 64 22 [ [ -LRB- cord-263469-2w26l80a 64 23 35 35 CD cord-263469-2w26l80a 64 24 ] ] -RRB- cord-263469-2w26l80a 64 25 was be VBD cord-263469-2w26l80a 64 26 used use VBN cord-263469-2w26l80a 64 27 to to TO cord-263469-2w26l80a 64 28 perform perform VB cord-263469-2w26l80a 64 29 regional regional JJ cord-263469-2w26l80a 64 30 alignments alignment NNS cord-263469-2w26l80a 64 31 . . . cord-263469-2w26l80a 65 1 PHD PHD NNP cord-263469-2w26l80a 65 2 ( ( -LRB- cord-263469-2w26l80a 65 3 Columbia Columbia NNP cord-263469-2w26l80a 65 4 University University NNP cord-263469-2w26l80a 65 5 Bioinformatics Bioinformatics NNP cord-263469-2w26l80a 65 6 Center Center NNP cord-263469-2w26l80a 65 7 , , , cord-263469-2w26l80a 65 8 http:// http:// NNP cord-263469-2w26l80a 65 9 cubic.bioc.columbia.edu/predictprotein/ cubic.bioc.columbia.edu/predictprotein/ NNP cord-263469-2w26l80a 65 10 ) ) -RRB- cord-263469-2w26l80a 65 11 , , , cord-263469-2w26l80a 65 12 which which WDT cord-263469-2w26l80a 65 13 is be VBZ cord-263469-2w26l80a 65 14 part part NN cord-263469-2w26l80a 65 15 of of IN cord-263469-2w26l80a 65 16 the the DT cord-263469-2w26l80a 65 17 ProteinPredict ProteinPredict NNP cord-263469-2w26l80a 65 18 suite suite NN cord-263469-2w26l80a 65 19 was be VBD cord-263469-2w26l80a 65 20 the the DT cord-263469-2w26l80a 65 21 preferred preferred JJ cord-263469-2w26l80a 65 22 method method NN cord-263469-2w26l80a 65 23 of of IN cord-263469-2w26l80a 65 24 secondary secondary JJ cord-263469-2w26l80a 65 25 structure structure NN cord-263469-2w26l80a 65 26 prediction prediction NN cord-263469-2w26l80a 65 27 [ [ -LRB- cord-263469-2w26l80a 65 28 36 36 CD cord-263469-2w26l80a 65 29 ] ] -RRB- cord-263469-2w26l80a 65 30 . . . cord-263469-2w26l80a 66 1 Domains domain NNS cord-263469-2w26l80a 66 2 with with IN cord-263469-2w26l80a 66 3 significant significant JJ cord-263469-2w26l80a 66 4 propensity propensity NN cord-263469-2w26l80a 66 5 to to TO cord-263469-2w26l80a 66 6 form form VB cord-263469-2w26l80a 66 7 transmembrane transmembrane NN cord-263469-2w26l80a 66 8 helices helix NNS cord-263469-2w26l80a 66 9 were be VBD cord-263469-2w26l80a 66 10 identified identify VBN cord-263469-2w26l80a 66 11 with with IN cord-263469-2w26l80a 66 12 TMpred TMpred NNP cord-263469-2w26l80a 66 13 ( ( -LRB- cord-263469-2w26l80a 66 14 ExPASy ExPASy NNP cord-263469-2w26l80a 66 15 , , , cord-263469-2w26l80a 66 16 Swiss Swiss NNP cord-263469-2w26l80a 66 17 Institute Institute NNP cord-263469-2w26l80a 66 18 of of IN cord-263469-2w26l80a 66 19 Bioinformatics Bioinformatics NNP cord-263469-2w26l80a 66 20 , , , cord-263469-2w26l80a 66 21 http://www.ch.embnet.org/software/ http://www.ch.embnet.org/software/ ADD cord-263469-2w26l80a 66 22 TMPRED_form.html TMPRED_form.html NNP cord-263469-2w26l80a 66 23 ) ) -RRB- cord-263469-2w26l80a 66 24 . . . cord-263469-2w26l80a 67 1 TMpred TMpred NNP cord-263469-2w26l80a 67 2 is be VBZ cord-263469-2w26l80a 67 3 based base VBN cord-263469-2w26l80a 67 4 on on IN cord-263469-2w26l80a 67 5 a a DT cord-263469-2w26l80a 67 6 statistical statistical JJ cord-263469-2w26l80a 67 7 analysis analysis NN cord-263469-2w26l80a 67 8 of of IN cord-263469-2w26l80a 67 9 TMbase TMbase NNP cord-263469-2w26l80a 67 10 , , , cord-263469-2w26l80a 67 11 a a DT cord-263469-2w26l80a 67 12 database database NN cord-263469-2w26l80a 67 13 of of IN cord-263469-2w26l80a 67 14 naturally naturally RB cord-263469-2w26l80a 67 15 occurring occur VBG cord-263469-2w26l80a 67 16 transmembrane transmembrane NN cord-263469-2w26l80a 67 17 glycoproteins glycoprotein NNS cord-263469-2w26l80a 67 18 [ [ -LRB- cord-263469-2w26l80a 67 19 37 37 CD cord-263469-2w26l80a 67 20 ] ] -RRB- cord-263469-2w26l80a 67 21 . . . cord-263469-2w26l80a 68 1 Sequences sequence NNS cord-263469-2w26l80a 68 2 with with IN cord-263469-2w26l80a 68 3 propensity propensity NN cord-263469-2w26l80a 68 4 to to TO cord-263469-2w26l80a 68 5 interface interface VB cord-263469-2w26l80a 68 6 with with IN cord-263469-2w26l80a 68 7 a a DT cord-263469-2w26l80a 68 8 lipid lipid NN cord-263469-2w26l80a 68 9 bilayer bilayer NN cord-263469-2w26l80a 68 10 were be VBD cord-263469-2w26l80a 68 11 identified identify VBN cord-263469-2w26l80a 68 12 with with IN cord-263469-2w26l80a 68 13 Membrane Membrane NNP cord-263469-2w26l80a 68 14 Protein Protein NNP cord-263469-2w26l80a 68 15 eXplorer eXplorer NNP cord-263469-2w26l80a 68 16 version version NN cord-263469-2w26l80a 68 17 3.0 3.0 CD cord-263469-2w26l80a 68 18 from from IN cord-263469-2w26l80a 68 19 the the DT cord-263469-2w26l80a 68 20 Stephen Stephen NNP cord-263469-2w26l80a 68 21 White White NNP cord-263469-2w26l80a 68 22 laboratory laboratory NN cord-263469-2w26l80a 68 23 using use VBG cord-263469-2w26l80a 68 24 default default NN cord-263469-2w26l80a 68 25 settings setting NNS cord-263469-2w26l80a 68 26 [ [ -LRB- cord-263469-2w26l80a 68 27 38 38 CD cord-263469-2w26l80a 68 28 ] ] -RRB- cord-263469-2w26l80a 68 29 , , , cord-263469-2w26l80a 68 30 which which WDT cord-263469-2w26l80a 68 31 can can MD cord-263469-2w26l80a 68 32 be be VB cord-263469-2w26l80a 68 33 used use VBN cord-263469-2w26l80a 68 34 to to TO cord-263469-2w26l80a 68 35 calculate calculate VB cord-263469-2w26l80a 68 36 scores score NNS cord-263469-2w26l80a 68 37 on on IN cord-263469-2w26l80a 68 38 the the DT cord-263469-2w26l80a 68 39 Wimley Wimley NNP cord-263469-2w26l80a 68 40 - - HYPH cord-263469-2w26l80a 68 41 White White NNP cord-263469-2w26l80a 68 42 interfacial interfacial JJ cord-263469-2w26l80a 68 43 hydrophobicity hydrophobicity NN cord-263469-2w26l80a 68 44 scale scale NN cord-263469-2w26l80a 68 45 ( ( -LRB- cord-263469-2w26l80a 68 46 WWIHS WWIHS NNP cord-263469-2w26l80a 68 47 ) ) -RRB- cord-263469-2w26l80a 68 48 [ [ -LRB- cord-263469-2w26l80a 68 49 39 39 CD cord-263469-2w26l80a 68 50 ] ] -RRB- cord-263469-2w26l80a 68 51 . . . cord-263469-2w26l80a 68 52 _SP cord-263469-2w26l80a 69 1 Proteomics Proteomics NNP cord-263469-2w26l80a 69 2 computational computational JJ cord-263469-2w26l80a 69 3 tools tool NNS cord-263469-2w26l80a 69 4 have have VBP cord-263469-2w26l80a 69 5 been be VBN cord-263469-2w26l80a 69 6 applied apply VBN cord-263469-2w26l80a 69 7 successfully successfully RB cord-263469-2w26l80a 69 8 to to TO cord-263469-2w26l80a 69 9 discover discover VB cord-263469-2w26l80a 69 10 potential potential JJ cord-263469-2w26l80a 69 11 structures structure NNS cord-263469-2w26l80a 69 12 of of IN cord-263469-2w26l80a 69 13 the the DT cord-263469-2w26l80a 69 14 VFP vfp NN cord-263469-2w26l80a 69 15 of of IN cord-263469-2w26l80a 69 16 retroviruses retrovirus NNS cord-263469-2w26l80a 69 17 , , , cord-263469-2w26l80a 69 18 filoviruses filovirus NNS cord-263469-2w26l80a 69 19 , , , cord-263469-2w26l80a 69 20 coronaviruses coronaviruse NNS cord-263469-2w26l80a 69 21 , , , cord-263469-2w26l80a 69 22 and and CC cord-263469-2w26l80a 69 23 baculoviruses baculoviruse NNS cord-263469-2w26l80a 69 24 [ [ -LRB- cord-263469-2w26l80a 69 25 22 22 CD cord-263469-2w26l80a 69 26 , , , cord-263469-2w26l80a 69 27 17 17 CD cord-263469-2w26l80a 69 28 , , , cord-263469-2w26l80a 69 29 18 18 CD cord-263469-2w26l80a 69 30 , , , cord-263469-2w26l80a 69 31 20 20 CD cord-263469-2w26l80a 69 32 , , , cord-263469-2w26l80a 69 33 21 21 CD cord-263469-2w26l80a 69 34 , , , cord-263469-2w26l80a 69 35 27 27 CD cord-263469-2w26l80a 69 36 , , , cord-263469-2w26l80a 69 37 28 28 CD cord-263469-2w26l80a 69 38 , , , cord-263469-2w26l80a 69 39 33 33 CD cord-263469-2w26l80a 69 40 ] ] -RRB- cord-263469-2w26l80a 69 41 . . . cord-263469-2w26l80a 70 1 Subsequent subsequent JJ cord-263469-2w26l80a 70 2 studies study NNS cord-263469-2w26l80a 70 3 , , , cord-263469-2w26l80a 70 4 using use VBG cord-263469-2w26l80a 70 5 Xray Xray NNP cord-263469-2w26l80a 70 6 crystallography crystallography NN cord-263469-2w26l80a 70 7 and and CC cord-263469-2w26l80a 70 8 other other JJ cord-263469-2w26l80a 70 9 methods method NNS cord-263469-2w26l80a 70 10 , , , cord-263469-2w26l80a 70 11 confirmed confirm VBD cord-263469-2w26l80a 70 12 all all DT cord-263469-2w26l80a 70 13 essential essential JJ cord-263469-2w26l80a 70 14 features feature NNS cord-263469-2w26l80a 70 15 of of IN cord-263469-2w26l80a 70 16 our -PRON- PRP$ cord-263469-2w26l80a 70 17 structural structural JJ cord-263469-2w26l80a 70 18 models model NNS cord-263469-2w26l80a 70 19 suggesting suggest VBG cord-263469-2w26l80a 70 20 that that IN cord-263469-2w26l80a 70 21 these these DT cord-263469-2w26l80a 70 22 modeling modeling NN cord-263469-2w26l80a 70 23 methods method NNS cord-263469-2w26l80a 70 24 are be VBP cord-263469-2w26l80a 70 25 highly highly RB cord-263469-2w26l80a 70 26 robust robust JJ cord-263469-2w26l80a 70 27 [ [ -LRB- cord-263469-2w26l80a 70 28 19 19 CD cord-263469-2w26l80a 70 29 , , , cord-263469-2w26l80a 70 30 40 40 CD cord-263469-2w26l80a 70 31 , , , cord-263469-2w26l80a 70 32 34 34 CD cord-263469-2w26l80a 70 33 ] ] -RRB- cord-263469-2w26l80a 70 34 . . . cord-263469-2w26l80a 71 1 The the DT cord-263469-2w26l80a 71 2 PHD PHD NNP cord-263469-2w26l80a 71 3 algorithm algorithm NN cord-263469-2w26l80a 71 4 predicts predict VBZ cord-263469-2w26l80a 71 5 protein protein NN cord-263469-2w26l80a 71 6 secondary secondary JJ cord-263469-2w26l80a 71 7 structure structure NN cord-263469-2w26l80a 71 8 from from IN cord-263469-2w26l80a 71 9 multiple multiple JJ cord-263469-2w26l80a 71 10 sequence sequence NN cord-263469-2w26l80a 71 11 alignments alignment NNS cord-263469-2w26l80a 71 12 by by IN cord-263469-2w26l80a 71 13 a a DT cord-263469-2w26l80a 71 14 system system NN cord-263469-2w26l80a 71 15 of of IN cord-263469-2w26l80a 71 16 neural neural JJ cord-263469-2w26l80a 71 17 networks network NNS cord-263469-2w26l80a 71 18 , , , cord-263469-2w26l80a 71 19 and and CC cord-263469-2w26l80a 71 20 is be VBZ cord-263469-2w26l80a 71 21 rated rate VBN cord-263469-2w26l80a 71 22 at at IN cord-263469-2w26l80a 71 23 an an DT cord-263469-2w26l80a 71 24 expected expect VBN cord-263469-2w26l80a 71 25 average average JJ cord-263469-2w26l80a 71 26 accuracy accuracy NN cord-263469-2w26l80a 71 27 of of IN cord-263469-2w26l80a 71 28 72 72 CD cord-263469-2w26l80a 71 29 % % NN cord-263469-2w26l80a 71 30 for for IN cord-263469-2w26l80a 71 31 three three CD cord-263469-2w26l80a 71 32 states state NNS cord-263469-2w26l80a 71 33 , , , cord-263469-2w26l80a 71 34 helix helix NN cord-263469-2w26l80a 71 35 , , , cord-263469-2w26l80a 71 36 strand strand NN cord-263469-2w26l80a 71 37 and and CC cord-263469-2w26l80a 71 38 loop loop VB cord-263469-2w26l80a 71 39 [ [ -LRB- cord-263469-2w26l80a 71 40 36 36 CD cord-263469-2w26l80a 71 41 ] ] -RRB- cord-263469-2w26l80a 71 42 . . . cord-263469-2w26l80a 72 1 This this DT cord-263469-2w26l80a 72 2 algorithm algorithm NN cord-263469-2w26l80a 72 3 predicts predict VBZ cord-263469-2w26l80a 72 4 that that IN cord-263469-2w26l80a 72 5 there there EX cord-263469-2w26l80a 72 6 is be VBZ cord-263469-2w26l80a 72 7 a a DT cord-263469-2w26l80a 72 8 region region NN cord-263469-2w26l80a 72 9 that that WDT cord-263469-2w26l80a 72 10 forms form VBZ cord-263469-2w26l80a 72 11 an an DT cord-263469-2w26l80a 72 12 extended extended JJ cord-263469-2w26l80a 72 13 α α NN cord-263469-2w26l80a 72 14 - - HYPH cord-263469-2w26l80a 72 15 helix helix NN cord-263469-2w26l80a 72 16 in in IN cord-263469-2w26l80a 72 17 BVD BVD NNP cord-263469-2w26l80a 72 18 G G NNP cord-263469-2w26l80a 73 1 ( ( -LRB- cord-263469-2w26l80a 73 2 aa aa NNP cord-263469-2w26l80a 73 3 284 284 CD cord-263469-2w26l80a 73 4 - - SYM cord-263469-2w26l80a 73 5 338 338 CD cord-263469-2w26l80a 73 6 ) ) -RRB- cord-263469-2w26l80a 73 7 and and CC cord-263469-2w26l80a 73 8 other other JJ cord-263469-2w26l80a 73 9 bornaviruses bornaviruse NNS cord-263469-2w26l80a 73 10 ( ( -LRB- cord-263469-2w26l80a 73 11 not not RB cord-263469-2w26l80a 73 12 shown show VBN cord-263469-2w26l80a 73 13 ) ) -RRB- cord-263469-2w26l80a 73 14 . . . cord-263469-2w26l80a 74 1 A a DT cord-263469-2w26l80a 74 2 prominent prominent JJ cord-263469-2w26l80a 74 3 feature feature NN cord-263469-2w26l80a 74 4 of of IN cord-263469-2w26l80a 74 5 class class NN cord-263469-2w26l80a 74 6 III iii CD cord-263469-2w26l80a 74 7 VFPs vfp NNS cord-263469-2w26l80a 74 8 is be VBZ cord-263469-2w26l80a 74 9 an an DT cord-263469-2w26l80a 74 10 extended extended JJ cord-263469-2w26l80a 74 11 α α NN cord-263469-2w26l80a 74 12 - - HYPH cord-263469-2w26l80a 74 13 helix helix NN cord-263469-2w26l80a 74 14 beginning beginning NN cord-263469-2w26l80a 74 15 near near IN cord-263469-2w26l80a 74 16 the the DT cord-263469-2w26l80a 74 17 carboxyl carboxyl NN cord-263469-2w26l80a 74 18 terminal terminal NN cord-263469-2w26l80a 74 19 third third RB cord-263469-2w26l80a 74 20 of of IN cord-263469-2w26l80a 74 21 the the DT cord-263469-2w26l80a 74 22 ectodomain ectodomain NNP cord-263469-2w26l80a 74 23 ( ( -LRB- cord-263469-2w26l80a 74 24 helix helix NNP cord-263469-2w26l80a 74 25 F F NNP cord-263469-2w26l80a 74 26 in in IN cord-263469-2w26l80a 74 27 domain domain NN cord-263469-2w26l80a 74 28 III III NNP cord-263469-2w26l80a 74 29 , , , cord-263469-2w26l80a 74 30 Fig Fig NNP cord-263469-2w26l80a 74 31 1 1 CD cord-263469-2w26l80a 74 32 ) ) -RRB- cord-263469-2w26l80a 74 33 , , , cord-263469-2w26l80a 74 34 which which WDT cord-263469-2w26l80a 74 35 is be VBZ cord-263469-2w26l80a 74 36 involved involve VBN cord-263469-2w26l80a 74 37 in in IN cord-263469-2w26l80a 74 38 trimerization trimerization NN cord-263469-2w26l80a 74 39 of of IN cord-263469-2w26l80a 74 40 the the DT cord-263469-2w26l80a 74 41 post post JJ cord-263469-2w26l80a 74 42 - - JJ cord-263469-2w26l80a 74 43 fusion fusion JJ cord-263469-2w26l80a 74 44 structure structure NN cord-263469-2w26l80a 74 45 [ [ -LRB- cord-263469-2w26l80a 74 46 30 30 CD cord-263469-2w26l80a 74 47 , , , cord-263469-2w26l80a 74 48 32 32 CD cord-263469-2w26l80a 74 49 , , , cord-263469-2w26l80a 74 50 34 34 CD cord-263469-2w26l80a 74 51 ] ] -RRB- cord-263469-2w26l80a 74 52 . . . cord-263469-2w26l80a 75 1 The the DT cord-263469-2w26l80a 75 2 longest long JJS cord-263469-2w26l80a 75 3 α α NN cord-263469-2w26l80a 75 4 - - HYPH cord-263469-2w26l80a 75 5 helix helix NN cord-263469-2w26l80a 75 6 predicted predict VBN cord-263469-2w26l80a 75 7 by by IN cord-263469-2w26l80a 75 8 PHD PHD NNP cord-263469-2w26l80a 75 9 in in IN cord-263469-2w26l80a 75 10 BVD BVD NNP cord-263469-2w26l80a 75 11 G G NNP cord-263469-2w26l80a 75 12 corresponds correspond VBZ cord-263469-2w26l80a 75 13 to to IN cord-263469-2w26l80a 75 14 this this DT cord-263469-2w26l80a 75 15 location location NN cord-263469-2w26l80a 76 1 ( ( -LRB- cord-263469-2w26l80a 76 2 Fig Fig NNP cord-263469-2w26l80a 76 3 . . NNP cord-263469-2w26l80a 76 4 1 1 CD cord-263469-2w26l80a 76 5 , , , cord-263469-2w26l80a 76 6 aa aa NNP cord-263469-2w26l80a 76 7 251 251 CD cord-263469-2w26l80a 76 8 - - HYPH cord-263469-2w26l80a 76 9 280 280 CD cord-263469-2w26l80a 76 10 ) ) -RRB- cord-263469-2w26l80a 76 11 . . . cord-263469-2w26l80a 77 1 Two two CD cord-263469-2w26l80a 77 2 shorter short JJR cord-263469-2w26l80a 77 3 helices helix NNS cord-263469-2w26l80a 77 4 corresponding correspond VBG cord-263469-2w26l80a 77 5 to to IN cord-263469-2w26l80a 77 6 helices helix NNS cord-263469-2w26l80a 77 7 G g NN cord-263469-2w26l80a 77 8 and and CC cord-263469-2w26l80a 77 9 H H NNP cord-263469-2w26l80a 77 10 of of IN cord-263469-2w26l80a 77 11 VSV VSV NNP cord-263469-2w26l80a 77 12 G G NNP cord-263469-2w26l80a 77 13 are be VBP cord-263469-2w26l80a 77 14 also also RB cord-263469-2w26l80a 77 15 predicted predict VBN cord-263469-2w26l80a 77 16 by by IN cord-263469-2w26l80a 77 17 the the DT cord-263469-2w26l80a 77 18 PHD PHD NNP cord-263469-2w26l80a 77 19 algorithm algorithm NN cord-263469-2w26l80a 77 20 in in IN cord-263469-2w26l80a 77 21 BVD BVD NNP cord-263469-2w26l80a 77 22 G G NNP cord-263469-2w26l80a 77 23 ( ( -LRB- cord-263469-2w26l80a 77 24 aa aa NNP cord-263469-2w26l80a 77 25 284 284 CD cord-263469-2w26l80a 77 26 - - SYM cord-263469-2w26l80a 77 27 297 297 CD cord-263469-2w26l80a 77 28 , , , cord-263469-2w26l80a 77 29 392 392 CD cord-263469-2w26l80a 77 30 - - SYM cord-263469-2w26l80a 77 31 402 402 CD cord-263469-2w26l80a 77 32 ) ) -RRB- cord-263469-2w26l80a 77 33 . . . cord-263469-2w26l80a 78 1 With with IN cord-263469-2w26l80a 78 2 the the DT cord-263469-2w26l80a 78 3 exception exception NN cord-263469-2w26l80a 78 4 of of IN cord-263469-2w26l80a 78 5 these these DT cord-263469-2w26l80a 78 6 α α NN cord-263469-2w26l80a 78 7 - - HYPH cord-263469-2w26l80a 78 8 helices helix NNS cord-263469-2w26l80a 78 9 , , , cord-263469-2w26l80a 78 10 the the DT cord-263469-2w26l80a 78 11 ectodomains ectodomain NNS cord-263469-2w26l80a 78 12 of of IN cord-263469-2w26l80a 78 13 BVD BVD NNP cord-263469-2w26l80a 78 14 G G NNP cord-263469-2w26l80a 78 15 are be VBP cord-263469-2w26l80a 78 16 predicted predict VBN cord-263469-2w26l80a 78 17 to to TO cord-263469-2w26l80a 78 18 be be VB cord-263469-2w26l80a 78 19 comprised comprise VBN cord-263469-2w26l80a 78 20 mostly mostly RB cord-263469-2w26l80a 78 21 of of IN cord-263469-2w26l80a 78 22 β β NN cord-263469-2w26l80a 78 23 - - HYPH cord-263469-2w26l80a 78 24 sheets sheet NNS cord-263469-2w26l80a 78 25 , , , cord-263469-2w26l80a 78 26 as as IN cord-263469-2w26l80a 78 27 is be VBZ cord-263469-2w26l80a 78 28 the the DT cord-263469-2w26l80a 78 29 case case NN cord-263469-2w26l80a 78 30 with with IN cord-263469-2w26l80a 78 31 other other JJ cord-263469-2w26l80a 78 32 class class NN cord-263469-2w26l80a 78 33 III iii CD cord-263469-2w26l80a 78 34 VFP VFP NNP cord-263469-2w26l80a 78 35 . . . cord-263469-2w26l80a 79 1 Another another DT cord-263469-2w26l80a 79 2 domain domain NN cord-263469-2w26l80a 79 3 identifiable identifiable JJ cord-263469-2w26l80a 79 4 with with IN cord-263469-2w26l80a 79 5 computational computational JJ cord-263469-2w26l80a 79 6 tools tool NNS cord-263469-2w26l80a 79 7 in in IN cord-263469-2w26l80a 79 8 BVD BVD NNP cord-263469-2w26l80a 79 9 G G NNP cord-263469-2w26l80a 79 10 is be VBZ cord-263469-2w26l80a 79 11 the the DT cord-263469-2w26l80a 79 12 carboxyl carboxyl NN cord-263469-2w26l80a 79 13 terminal terminal NN cord-263469-2w26l80a 79 14 transmembrane transmembrane NNP cord-263469-2w26l80a 79 15 anchor anchor NN cord-263469-2w26l80a 79 16 . . . cord-263469-2w26l80a 80 1 TMpred TMpred NNP cord-263469-2w26l80a 80 2 , , , cord-263469-2w26l80a 80 3 an an DT cord-263469-2w26l80a 80 4 algorithm algorithm NN cord-263469-2w26l80a 80 5 that that WDT cord-263469-2w26l80a 80 6 identifies identify VBZ cord-263469-2w26l80a 80 7 possible possible JJ cord-263469-2w26l80a 80 8 transmembrane transmembrane NN cord-263469-2w26l80a 80 9 helices helix NNS cord-263469-2w26l80a 80 10 , , , cord-263469-2w26l80a 80 11 assigns assign VBZ cord-263469-2w26l80a 80 12 a a DT cord-263469-2w26l80a 80 13 significant significant JJ cord-263469-2w26l80a 80 14 score score NN cord-263469-2w26l80a 80 15 ( ( -LRB- cord-263469-2w26l80a 80 16 2578 2578 CD cord-263469-2w26l80a 80 17 , , , cord-263469-2w26l80a 80 18 > > XX cord-263469-2w26l80a 81 1 500 500 CD cord-263469-2w26l80a 81 2 is be VBZ cord-263469-2w26l80a 81 3 statistically statistically RB cord-263469-2w26l80a 81 4 significant significant JJ cord-263469-2w26l80a 81 5 ) ) -RRB- cord-263469-2w26l80a 81 6 to to IN cord-263469-2w26l80a 81 7 BVD BVD NNP cord-263469-2w26l80a 81 8 G G NNP cord-263469-2w26l80a 81 9 aa aa NNP cord-263469-2w26l80a 81 10 468 468 CD cord-263469-2w26l80a 81 11 - - SYM cord-263469-2w26l80a 81 12 493 493 CD cord-263469-2w26l80a 81 13 , , , cord-263469-2w26l80a 81 14 which which WDT cord-263469-2w26l80a 81 15 suggests suggest VBZ cord-263469-2w26l80a 81 16 that that IN cord-263469-2w26l80a 81 17 this this DT cord-263469-2w26l80a 81 18 sequence sequence NN cord-263469-2w26l80a 81 19 includes include VBZ cord-263469-2w26l80a 81 20 the the DT cord-263469-2w26l80a 81 21 transmembrane transmembrane NNP cord-263469-2w26l80a 81 22 anchor anchor NN cord-263469-2w26l80a 81 23 ( ( -LRB- cord-263469-2w26l80a 81 24 violet violet NN cord-263469-2w26l80a 81 25 cones cone NNS cord-263469-2w26l80a 81 26 ) ) -RRB- cord-263469-2w26l80a 81 27 . . . cord-263469-2w26l80a 82 1 Two two CD cord-263469-2w26l80a 82 2 other other JJ cord-263469-2w26l80a 82 3 potential potential JJ cord-263469-2w26l80a 82 4 TM TM NNP cord-263469-2w26l80a 82 5 segments segment NNS cord-263469-2w26l80a 82 6 are be VBP cord-263469-2w26l80a 82 7 present present JJ cord-263469-2w26l80a 82 8 in in IN cord-263469-2w26l80a 82 9 BDV BDV NNP cord-263469-2w26l80a 82 10 G G NNP cord-263469-2w26l80a 82 11 ( ( -LRB- cord-263469-2w26l80a 82 12 274 274 CD cord-263469-2w26l80a 82 13 - - SYM cord-263469-2w26l80a 82 14 294 294 CD cord-263469-2w26l80a 82 15 and and CC cord-263469-2w26l80a 82 16 303 303 CD cord-263469-2w26l80a 82 17 - - SYM cord-263469-2w26l80a 82 18 327 327 CD cord-263469-2w26l80a 82 19 ) ) -RRB- cord-263469-2w26l80a 82 20 . . . cord-263469-2w26l80a 83 1 However however RB cord-263469-2w26l80a 83 2 , , , cord-263469-2w26l80a 83 3 it -PRON- PRP cord-263469-2w26l80a 83 4 is be VBZ cord-263469-2w26l80a 83 5 not not RB cord-263469-2w26l80a 83 6 likely likely JJ cord-263469-2w26l80a 83 7 that that IN cord-263469-2w26l80a 83 8 these these DT cord-263469-2w26l80a 83 9 regions region NNS cord-263469-2w26l80a 83 10 are be VBP cord-263469-2w26l80a 83 11 embedded embed VBN cord-263469-2w26l80a 83 12 in in IN cord-263469-2w26l80a 83 13 the the DT cord-263469-2w26l80a 83 14 membrane membrane NN cord-263469-2w26l80a 83 15 , , , cord-263469-2w26l80a 83 16 either either CC cord-263469-2w26l80a 83 17 in in IN cord-263469-2w26l80a 83 18 G G NNP cord-263469-2w26l80a 83 19 or or CC cord-263469-2w26l80a 83 20 GP2 GP2 NNP cord-263469-2w26l80a 83 21 because because IN cord-263469-2w26l80a 83 22 of of IN cord-263469-2w26l80a 83 23 the the DT cord-263469-2w26l80a 83 24 likely likely JJ cord-263469-2w26l80a 83 25 dicysteine dicysteine JJ cord-263469-2w26l80a 83 26 bonding bonding NN cord-263469-2w26l80a 83 27 between between IN cord-263469-2w26l80a 83 28 cysteines cysteine NNS cord-263469-2w26l80a 83 29 272 272 CD cord-263469-2w26l80a 83 30 and and CC cord-263469-2w26l80a 83 31 317 317 CD cord-263469-2w26l80a 83 32 or or CC cord-263469-2w26l80a 83 33 other other JJ cord-263469-2w26l80a 83 34 potential potential JJ cord-263469-2w26l80a 83 35 linkages linkage NNS cord-263469-2w26l80a 83 36 involving involve VBG cord-263469-2w26l80a 83 37 cysteine cysteine NN cord-263469-2w26l80a 83 38 317 317 CD cord-263469-2w26l80a 83 39 . . . cord-263469-2w26l80a 84 1 PHD PHD NNP cord-263469-2w26l80a 84 2 analyses analysis NNS cord-263469-2w26l80a 84 3 also also RB cord-263469-2w26l80a 84 4 predict predict VBP cord-263469-2w26l80a 84 5 the the DT cord-263469-2w26l80a 84 6 presence presence NN cord-263469-2w26l80a 84 7 of of IN cord-263469-2w26l80a 84 8 an an DT cord-263469-2w26l80a 84 9 α α XX cord-263469-2w26l80a 84 10 - - HYPH cord-263469-2w26l80a 84 11 helical helical JJ cord-263469-2w26l80a 84 12 stem stem NN cord-263469-2w26l80a 84 13 domain domain NN cord-263469-2w26l80a 84 14 with with IN cord-263469-2w26l80a 84 15 several several JJ cord-263469-2w26l80a 84 16 aromatic aromatic JJ cord-263469-2w26l80a 84 17 aa aa NN cord-263469-2w26l80a 84 18 prior prior RB cord-263469-2w26l80a 84 19 to to IN cord-263469-2w26l80a 84 20 the the DT cord-263469-2w26l80a 84 21 transmembrane transmembrane NNP cord-263469-2w26l80a 84 22 anchor anchor NN cord-263469-2w26l80a 84 23 ( ( -LRB- cord-263469-2w26l80a 84 24 aa aa NNP cord-263469-2w26l80a 84 25 445 445 CD cord-263469-2w26l80a 84 26 - - SYM cord-263469-2w26l80a 84 27 474 474 CD cord-263469-2w26l80a 84 28 ) ) -RRB- cord-263469-2w26l80a 84 29 , , , cord-263469-2w26l80a 84 30 a a DT cord-263469-2w26l80a 84 31 feature feature NN cord-263469-2w26l80a 84 32 present present JJ cord-263469-2w26l80a 84 33 in in IN cord-263469-2w26l80a 84 34 both both DT cord-263469-2w26l80a 84 35 class class NN cord-263469-2w26l80a 84 36 II II NNP cord-263469-2w26l80a 84 37 and and CC cord-263469-2w26l80a 84 38 III iii CD cord-263469-2w26l80a 84 39 VFP VFP NNP cord-263469-2w26l80a 84 40 [ [ -LRB- cord-263469-2w26l80a 84 41 41 41 CD cord-263469-2w26l80a 84 42 , , , cord-263469-2w26l80a 84 43 42 42 CD cord-263469-2w26l80a 84 44 ] ] -RRB- cord-263469-2w26l80a 84 45 . . . cord-263469-2w26l80a 85 1 Therefore therefore RB cord-263469-2w26l80a 85 2 , , , cord-263469-2w26l80a 85 3 we -PRON- PRP cord-263469-2w26l80a 85 4 have have VBP cord-263469-2w26l80a 85 5 designated designate VBN cord-263469-2w26l80a 85 6 the the DT cord-263469-2w26l80a 85 7 sequence sequence NN cord-263469-2w26l80a 85 8 475 475 CD cord-263469-2w26l80a 85 9 - - SYM cord-263469-2w26l80a 85 10 493 493 CD cord-263469-2w26l80a 85 11 as as IN cord-263469-2w26l80a 85 12 the the DT cord-263469-2w26l80a 85 13 transmembrane transmembrane NN cord-263469-2w26l80a 85 14 anchor anchor NN cord-263469-2w26l80a 85 15 , , , cord-263469-2w26l80a 85 16 recognizing recognize VBG cord-263469-2w26l80a 85 17 that that IN cord-263469-2w26l80a 85 18 the the DT cord-263469-2w26l80a 85 19 stem stem NN cord-263469-2w26l80a 85 20 domain domain NN cord-263469-2w26l80a 85 21 , , , cord-263469-2w26l80a 85 22 which which WDT cord-263469-2w26l80a 85 23 contains contain VBZ cord-263469-2w26l80a 85 24 several several JJ cord-263469-2w26l80a 85 25 aromatic aromatic JJ cord-263469-2w26l80a 85 26 amino amino NN cord-263469-2w26l80a 85 27 acids acid NNS cord-263469-2w26l80a 85 28 , , , cord-263469-2w26l80a 85 29 is be VBZ cord-263469-2w26l80a 85 30 likely likely JJ cord-263469-2w26l80a 85 31 to to TO cord-263469-2w26l80a 85 32 interface interface VB cord-263469-2w26l80a 85 33 with with IN cord-263469-2w26l80a 85 34 the the DT cord-263469-2w26l80a 85 35 viral viral JJ cord-263469-2w26l80a 85 36 membrane membrane NN cord-263469-2w26l80a 85 37 . . . cord-263469-2w26l80a 86 1 The the DT cord-263469-2w26l80a 86 2 fusion fusion NN cord-263469-2w26l80a 86 3 domains domain NNS cord-263469-2w26l80a 86 4 ( ( -LRB- cord-263469-2w26l80a 86 5 referred refer VBN cord-263469-2w26l80a 86 6 to to IN cord-263469-2w26l80a 86 7 here here RB cord-263469-2w26l80a 86 8 as as IN cord-263469-2w26l80a 86 9 domain domain NN cord-263469-2w26l80a 86 10 II II NNP cord-263469-2w26l80a 86 11 ) ) -RRB- cord-263469-2w26l80a 86 12 of of IN cord-263469-2w26l80a 86 13 all all DT cord-263469-2w26l80a 86 14 class class NN cord-263469-2w26l80a 86 15 II II NNP cord-263469-2w26l80a 86 16 or or CC cord-263469-2w26l80a 86 17 III iii CD cord-263469-2w26l80a 86 18 VFP VFP NNP cord-263469-2w26l80a 86 19 contain contain VBP cord-263469-2w26l80a 86 20 1 1 CD cord-263469-2w26l80a 86 21 or or CC cord-263469-2w26l80a 86 22 2 2 CD cord-263469-2w26l80a 86 23 fusion fusion NN cord-263469-2w26l80a 86 24 loops loop NNS cord-263469-2w26l80a 86 25 , , , cord-263469-2w26l80a 86 26 which which WDT cord-263469-2w26l80a 86 27 give give VBP cord-263469-2w26l80a 86 28 significant significant JJ cord-263469-2w26l80a 86 29 scores score NNS cord-263469-2w26l80a 86 30 on on IN cord-263469-2w26l80a 86 31 the the DT cord-263469-2w26l80a 86 32 WWIHS WWIHS NNP cord-263469-2w26l80a 86 33 [ [ -LRB- cord-263469-2w26l80a 86 34 39 39 CD cord-263469-2w26l80a 86 35 ] ] -RRB- cord-263469-2w26l80a 86 36 . . . cord-263469-2w26l80a 87 1 Sequences sequence NNS cord-263469-2w26l80a 87 2 with with IN cord-263469-2w26l80a 87 3 positive positive JJ cord-263469-2w26l80a 87 4 WWIHS WWIHS NNP cord-263469-2w26l80a 87 5 have have VBP cord-263469-2w26l80a 87 6 a a DT cord-263469-2w26l80a 87 7 high high JJ cord-263469-2w26l80a 87 8 potential potential NN cord-263469-2w26l80a 87 9 to to IN cord-263469-2w26l80a 87 10 interface interface VB cord-263469-2w26l80a 87 11 with with IN cord-263469-2w26l80a 87 12 or or CC cord-263469-2w26l80a 87 13 disrupt disrupt VB cord-263469-2w26l80a 87 14 lipid lipid NN cord-263469-2w26l80a 87 15 membranes membrane NNS cord-263469-2w26l80a 87 16 , , , cord-263469-2w26l80a 87 17 and and CC cord-263469-2w26l80a 87 18 therefore therefore RB cord-263469-2w26l80a 87 19 are be VBP cord-263469-2w26l80a 87 20 key key JJ cord-263469-2w26l80a 87 21 features feature NNS cord-263469-2w26l80a 87 22 of of IN cord-263469-2w26l80a 87 23 VFP VFP NNP cord-263469-2w26l80a 87 24 . . . cord-263469-2w26l80a 88 1 Another another DT cord-263469-2w26l80a 88 2 feature feature NN cord-263469-2w26l80a 88 3 of of IN cord-263469-2w26l80a 88 4 the the DT cord-263469-2w26l80a 88 5 fusion fusion NN cord-263469-2w26l80a 88 6 domains domain NNS cord-263469-2w26l80a 88 7 of of IN cord-263469-2w26l80a 88 8 class class NN cord-263469-2w26l80a 88 9 II II NNP cord-263469-2w26l80a 88 10 and and CC cord-263469-2w26l80a 88 11 III III NNP cord-263469-2w26l80a 88 12 VFP VFP NNP cord-263469-2w26l80a 88 13 is be VBZ cord-263469-2w26l80a 88 14 the the DT cord-263469-2w26l80a 88 15 presence presence NN cord-263469-2w26l80a 88 16 of of IN cord-263469-2w26l80a 88 17 several several JJ cord-263469-2w26l80a 88 18 dicysteine dicysteine JJ cord-263469-2w26l80a 88 19 bonds bond NNS cord-263469-2w26l80a 88 20 , , , cord-263469-2w26l80a 88 21 which which WDT cord-263469-2w26l80a 88 22 stabilize stabilize VBP cord-263469-2w26l80a 88 23 the the DT cord-263469-2w26l80a 88 24 overall overall JJ cord-263469-2w26l80a 88 25 domain domain NN cord-263469-2w26l80a 88 26 architecture architecture NN cord-263469-2w26l80a 88 27 . . . cord-263469-2w26l80a 89 1 A a DT cord-263469-2w26l80a 89 2 region region NN cord-263469-2w26l80a 89 3 in in IN cord-263469-2w26l80a 89 4 bornavirus bornavirus NNP cord-263469-2w26l80a 89 5 G G NNP cord-263469-2w26l80a 89 6 ( ( -LRB- cord-263469-2w26l80a 89 7 BVD BVD NNP cord-263469-2w26l80a 89 8 aa aa NNP cord-263469-2w26l80a 89 9 66 66 CD cord-263469-2w26l80a 89 10 - - SYM cord-263469-2w26l80a 89 11 183 183 CD cord-263469-2w26l80a 89 12 ) ) -RRB- cord-263469-2w26l80a 89 13 with with IN cord-263469-2w26l80a 89 14 12 12 CD cord-263469-2w26l80a 89 15 cysteine cysteine NN cord-263469-2w26l80a 89 16 residues residue NNS cord-263469-2w26l80a 89 17 , , , cord-263469-2w26l80a 89 18 plus plus CC cord-263469-2w26l80a 89 19 2 2 CD cord-263469-2w26l80a 89 20 sequences sequence NNS cord-263469-2w26l80a 89 21 with with IN cord-263469-2w26l80a 89 22 positive positive JJ cord-263469-2w26l80a 89 23 WWIHS wwihs NN cord-263469-2w26l80a 89 24 scores score NNS cord-263469-2w26l80a 89 25 ( ( -LRB- cord-263469-2w26l80a 89 26 Fig Fig NNP cord-263469-2w26l80a 89 27 . . NNP cord-263469-2w26l80a 89 28 1 1 CD cord-263469-2w26l80a 89 29 , , , cord-263469-2w26l80a 89 30 red red JJ cord-263469-2w26l80a 89 31 , , , cord-263469-2w26l80a 89 32 74 74 CD cord-263469-2w26l80a 89 33 - - SYM cord-263469-2w26l80a 89 34 102 102 CD cord-263469-2w26l80a 89 35 , , , cord-263469-2w26l80a 89 36 119 119 CD cord-263469-2w26l80a 89 37 - - SYM cord-263469-2w26l80a 89 38 155 155 CD cord-263469-2w26l80a 89 39 ) ) -RRB- cord-263469-2w26l80a 89 40 is be VBZ cord-263469-2w26l80a 89 41 likely likely JJ cord-263469-2w26l80a 89 42 to to TO cord-263469-2w26l80a 89 43 represent represent VB cord-263469-2w26l80a 89 44 the the DT cord-263469-2w26l80a 89 45 fusion fusion NN cord-263469-2w26l80a 89 46 domain domain NN cord-263469-2w26l80a 89 47 of of IN cord-263469-2w26l80a 89 48 BDV BDV NNP cord-263469-2w26l80a 89 49 G. G. NNP cord-263469-2w26l80a 89 50 Sequence sequence NN cord-263469-2w26l80a 89 51 similarities similarity NNS cord-263469-2w26l80a 89 52 between between IN cord-263469-2w26l80a 89 53 VSV VSV NNP cord-263469-2w26l80a 89 54 and and CC cord-263469-2w26l80a 89 55 BDV BDV NNP cord-263469-2w26l80a 89 56 G G NNP cord-263469-2w26l80a 89 57 do do VBP cord-263469-2w26l80a 89 58 not not RB cord-263469-2w26l80a 89 59 permit permit VB cord-263469-2w26l80a 89 60 alignment alignment NN cord-263469-2w26l80a 89 61 by by IN cord-263469-2w26l80a 89 62 computational computational JJ cord-263469-2w26l80a 89 63 methods method NNS cord-263469-2w26l80a 89 64 alone alone RB cord-263469-2w26l80a 89 65 . . . cord-263469-2w26l80a 90 1 However however RB cord-263469-2w26l80a 90 2 , , , cord-263469-2w26l80a 90 3 using use VBG cord-263469-2w26l80a 90 4 the the DT cord-263469-2w26l80a 90 5 regions region NNS cord-263469-2w26l80a 90 6 of of IN cord-263469-2w26l80a 90 7 local local JJ cord-263469-2w26l80a 90 8 structural structural JJ cord-263469-2w26l80a 90 9 similarity similarity NN cord-263469-2w26l80a 90 10 including include VBG cord-263469-2w26l80a 90 11 the the DT cord-263469-2w26l80a 90 12 putative putative JJ cord-263469-2w26l80a 90 13 fusion fusion NN cord-263469-2w26l80a 90 14 domain domain NN cord-263469-2w26l80a 90 15 / / SYM cord-263469-2w26l80a 90 16 loops loop NNS cord-263469-2w26l80a 90 17 , , , cord-263469-2w26l80a 90 18 extended extended JJ cord-263469-2w26l80a 90 19 αhelices αhelice NNS cord-263469-2w26l80a 90 20 and and CC cord-263469-2w26l80a 90 21 transmembrane transmembrane NN cord-263469-2w26l80a 90 22 domains domain NNS cord-263469-2w26l80a 90 23 , , , cord-263469-2w26l80a 90 24 all all DT cord-263469-2w26l80a 90 25 of of IN cord-263469-2w26l80a 90 26 which which WDT cord-263469-2w26l80a 90 27 are be VBP cord-263469-2w26l80a 90 28 collinear collinear JJ cord-263469-2w26l80a 90 29 , , , cord-263469-2w26l80a 90 30 alignments alignment NNS cord-263469-2w26l80a 90 31 between between IN cord-263469-2w26l80a 90 32 VSV VSV NNP cord-263469-2w26l80a 90 33 and and CC cord-263469-2w26l80a 90 34 BDV BDV NNP cord-263469-2w26l80a 90 35 G G NNP cord-263469-2w26l80a 90 36 are be VBP cord-263469-2w26l80a 90 37 proposed propose VBN cord-263469-2w26l80a 90 38 ( ( -LRB- cord-263469-2w26l80a 90 39 Figs fig NNS cord-263469-2w26l80a 90 40 . . . cord-263469-2w26l80a 91 1 1 1 CD cord-263469-2w26l80a 91 2 , , , cord-263469-2w26l80a 91 3 2 2 CD cord-263469-2w26l80a 91 4 ) ) -RRB- cord-263469-2w26l80a 91 5 . . . cord-263469-2w26l80a 92 1 These these DT cord-263469-2w26l80a 92 2 alignments alignment NNS cord-263469-2w26l80a 92 3 support support VBP cord-263469-2w26l80a 92 4 assignment assignment NN cord-263469-2w26l80a 92 5 of of IN cord-263469-2w26l80a 92 6 a a DT cord-263469-2w26l80a 92 7 class class NN cord-263469-2w26l80a 92 8 III iii CD cord-263469-2w26l80a 92 9 domain domain NN cord-263469-2w26l80a 92 10 architecture architecture NN cord-263469-2w26l80a 92 11 to to IN cord-263469-2w26l80a 92 12 BDV BDV NNP cord-263469-2w26l80a 92 13 G. G. NNP cord-263469-2w26l80a 93 1 The the DT cord-263469-2w26l80a 93 2 proposed propose VBN cord-263469-2w26l80a 93 3 domains domain NNS cord-263469-2w26l80a 93 4 of of IN cord-263469-2w26l80a 93 5 bornavirus bornavirus NNP cord-263469-2w26l80a 93 6 G G NNP cord-263469-2w26l80a 93 7 are be VBP cord-263469-2w26l80a 93 8 also also RB cord-263469-2w26l80a 93 9 collinear collinear JJ cord-263469-2w26l80a 93 10 with with IN cord-263469-2w26l80a 93 11 analogous analogous JJ cord-263469-2w26l80a 93 12 domains domain NNS cord-263469-2w26l80a 93 13 of of IN cord-263469-2w26l80a 93 14 herpesvirus herpesvirus NNP cord-263469-2w26l80a 93 15 gB gB NNP cord-263469-2w26l80a 93 16 , , , cord-263469-2w26l80a 93 17 the the DT cord-263469-2w26l80a 93 18 other other JJ cord-263469-2w26l80a 93 19 -albeit -albeit : cord-263469-2w26l80a 93 20 much much RB cord-263469-2w26l80a 93 21 longer long JJR cord-263469-2w26l80a 93 22 -prototypic -prototypic JJ cord-263469-2w26l80a 93 23 class class NN cord-263469-2w26l80a 93 24 III III NNP cord-263469-2w26l80a 93 25 VFP VFP NNP cord-263469-2w26l80a 93 26 , , , cord-263469-2w26l80a 93 27 as as RB cord-263469-2w26l80a 93 28 well well RB cord-263469-2w26l80a 93 29 as as IN cord-263469-2w26l80a 93 30 GP64 GP64 NNP cord-263469-2w26l80a 93 31 superfamily superfamily NN cord-263469-2w26l80a 93 32 proteins protein NNS cord-263469-2w26l80a 93 33 encoded encode VBN cord-263469-2w26l80a 93 34 by by IN cord-263469-2w26l80a 93 35 baculoviruses baculoviruse NNS cord-263469-2w26l80a 93 36 and and CC cord-263469-2w26l80a 93 37 thogotoviruses thogotoviruse NNS cord-263469-2w26l80a 94 1 ( ( -LRB- cord-263469-2w26l80a 94 2 Fig Fig NNP cord-263469-2w26l80a 94 3 . . NNP cord-263469-2w26l80a 94 4 2 2 CD cord-263469-2w26l80a 94 5 ) ) -RRB- cord-263469-2w26l80a 94 6 . . . cord-263469-2w26l80a 95 1 BDV BDV NNP cord-263469-2w26l80a 95 2 G G NNP cord-263469-2w26l80a 95 3 is be VBZ cord-263469-2w26l80a 95 4 more more RBR cord-263469-2w26l80a 95 5 heavily heavily RB cord-263469-2w26l80a 95 6 glycosylated glycosylate VBN cord-263469-2w26l80a 95 7 than than IN cord-263469-2w26l80a 95 8 VSV VSV NNP cord-263469-2w26l80a 95 9 G G NNP cord-263469-2w26l80a 95 10 , , , cord-263469-2w26l80a 95 11 THOV THOV NNP cord-263469-2w26l80a 95 12 G g NN cord-263469-2w26l80a 95 13 or or CC cord-263469-2w26l80a 95 14 baculovirus baculovirus NN cord-263469-2w26l80a 95 15 GP64 GP64 NNP cord-263469-2w26l80a 95 16 , , , cord-263469-2w26l80a 95 17 It -PRON- PRP cord-263469-2w26l80a 95 18 is be VBZ cord-263469-2w26l80a 95 19 also also RB cord-263469-2w26l80a 95 20 more more RBR cord-263469-2w26l80a 95 21 heavily heavily RB cord-263469-2w26l80a 95 22 glycosylated glycosylate VBN cord-263469-2w26l80a 95 23 than than IN cord-263469-2w26l80a 95 24 gB gB NNP cord-263469-2w26l80a 95 25 of of IN cord-263469-2w26l80a 95 26 HSV-1 HSV-1 NNP cord-263469-2w26l80a 96 1 ( ( -LRB- cord-263469-2w26l80a 96 2 Fig Fig NNP cord-263469-2w26l80a 96 3 . . NNP cord-263469-2w26l80a 96 4 2 2 CD cord-263469-2w26l80a 96 5 ) ) -RRB- cord-263469-2w26l80a 96 6 . . . cord-263469-2w26l80a 97 1 Cytomegalovirus Cytomegalovirus NNP cord-263469-2w26l80a 97 2 ( ( -LRB- cord-263469-2w26l80a 97 3 CMV CMV NNP cord-263469-2w26l80a 97 4 ) ) -RRB- cord-263469-2w26l80a 97 5 and and CC cord-263469-2w26l80a 97 6 Epstein Epstein NNP cord-263469-2w26l80a 97 7 - - HYPH cord-263469-2w26l80a 97 8 Barr Barr NNP cord-263469-2w26l80a 97 9 virus virus NN cord-263469-2w26l80a 97 10 ( ( -LRB- cord-263469-2w26l80a 97 11 EBV EBV NNP cord-263469-2w26l80a 97 12 ) ) -RRB- cord-263469-2w26l80a 98 1 gB gB NNP cord-263469-2w26l80a 98 2 are be VBP cord-263469-2w26l80a 98 3 closely closely RB cord-263469-2w26l80a 98 4 related relate VBN cord-263469-2w26l80a 98 5 in in IN cord-263469-2w26l80a 98 6 sequence sequence NN cord-263469-2w26l80a 98 7 to to IN cord-263469-2w26l80a 98 8 HSV-1 HSV-1 NNP cord-263469-2w26l80a 98 9 gB. gb. XX cord-263469-2w26l80a 99 1 Recent recent JJ cord-263469-2w26l80a 99 2 studies study NNS cord-263469-2w26l80a 99 3 confirm confirm VBP cord-263469-2w26l80a 99 4 that that IN cord-263469-2w26l80a 99 5 EBV EBV NNP cord-263469-2w26l80a 99 6 gB gB NNP cord-263469-2w26l80a 99 7 is be VBZ cord-263469-2w26l80a 99 8 a a DT cord-263469-2w26l80a 99 9 class class NN cord-263469-2w26l80a 99 10 II II NNP cord-263469-2w26l80a 99 11 VFP VFP NNP cord-263469-2w26l80a 99 12 [ [ -LRB- cord-263469-2w26l80a 99 13 43 43 CD cord-263469-2w26l80a 99 14 ] ] -RRB- cord-263469-2w26l80a 99 15 , , , cord-263469-2w26l80a 99 16 and and CC cord-263469-2w26l80a 99 17 it -PRON- PRP cord-263469-2w26l80a 99 18 is be VBZ cord-263469-2w26l80a 99 19 likely likely JJ cord-263469-2w26l80a 99 20 that that IN cord-263469-2w26l80a 99 21 all all DT cord-263469-2w26l80a 99 22 herpesvirus herpesvirus NN cord-263469-2w26l80a 99 23 gB gB NNP cord-263469-2w26l80a 99 24 are be VBP cord-263469-2w26l80a 99 25 class class NN cord-263469-2w26l80a 99 26 II II NNP cord-263469-2w26l80a 99 27 VFP VFP NNP cord-263469-2w26l80a 99 28 . . . cord-263469-2w26l80a 100 1 CMV CMV NNP cord-263469-2w26l80a 100 2 gB gB NNP cord-263469-2w26l80a 100 3 is be VBZ cord-263469-2w26l80a 100 4 glycosylated glycosylate VBN cord-263469-2w26l80a 100 5 to to IN cord-263469-2w26l80a 100 6 a a DT cord-263469-2w26l80a 100 7 similar similar JJ cord-263469-2w26l80a 100 8 extent extent NN cord-263469-2w26l80a 100 9 as as IN cord-263469-2w26l80a 100 10 BDV BDV NNP cord-263469-2w26l80a 100 11 G G NNP cord-263469-2w26l80a 100 12 , , , cord-263469-2w26l80a 100 13 while while IN cord-263469-2w26l80a 100 14 EBV EBV NNP cord-263469-2w26l80a 100 15 gB gB NNP cord-263469-2w26l80a 100 16 has have VBZ cord-263469-2w26l80a 100 17 an an DT cord-263469-2w26l80a 100 18 intermediate intermediate JJ cord-263469-2w26l80a 100 19 level level NN cord-263469-2w26l80a 100 20 of of IN cord-263469-2w26l80a 100 21 glycosylation glycosylation NN cord-263469-2w26l80a 100 22 . . . cord-263469-2w26l80a 101 1 Therefore therefore RB cord-263469-2w26l80a 101 2 , , , cord-263469-2w26l80a 101 3 a a DT cord-263469-2w26l80a 101 4 high high JJ cord-263469-2w26l80a 101 5 level level NN cord-263469-2w26l80a 101 6 of of IN cord-263469-2w26l80a 101 7 glycosylation glycosylation NN cord-263469-2w26l80a 101 8 does do VBZ cord-263469-2w26l80a 101 9 not not RB cord-263469-2w26l80a 101 10 preclude preclude VB cord-263469-2w26l80a 101 11 the the DT cord-263469-2w26l80a 101 12 possibility possibility NN cord-263469-2w26l80a 101 13 that that IN cord-263469-2w26l80a 101 14 BDV BDV NNP cord-263469-2w26l80a 101 15 G G NNP cord-263469-2w26l80a 101 16 is be VBZ cord-263469-2w26l80a 101 17 a a DT cord-263469-2w26l80a 101 18 class class NN cord-263469-2w26l80a 101 19 III iii NN cord-263469-2w26l80a 101 20 VFP vfp NN cord-263469-2w26l80a 101 21 . . . cord-263469-2w26l80a 102 1 BDV BDV NNP cord-263469-2w26l80a 102 2 G G NNP cord-263469-2w26l80a 102 3 and and CC cord-263469-2w26l80a 102 4 other other JJ cord-263469-2w26l80a 102 5 bornavirus bornavirus NNP cord-263469-2w26l80a 102 6 G G NNP cord-263469-2w26l80a 102 7 have have VBP cord-263469-2w26l80a 102 8 consensus consensus NN cord-263469-2w26l80a 102 9 furin furin NN cord-263469-2w26l80a 102 10 cleavage cleavage NN cord-263469-2w26l80a 102 11 sites site NNS cord-263469-2w26l80a 102 12 ( ( -LRB- cord-263469-2w26l80a 102 13 RRRR RRRR NNP cord-263469-2w26l80a 102 14 ) ) -RRB- cord-263469-2w26l80a 103 1 prior prior RB cord-263469-2w26l80a 103 2 to to IN cord-263469-2w26l80a 103 3 the the DT cord-263469-2w26l80a 103 4 extended extended JJ cord-263469-2w26l80a 103 5 α α NNP cord-263469-2w26l80a 103 6 helix helix NN cord-263469-2w26l80a 103 7 ( ( -LRB- cord-263469-2w26l80a 103 8 Fig Fig NNP cord-263469-2w26l80a 103 9 . . NNP cord-263469-2w26l80a 103 10 1 1 CD cord-263469-2w26l80a 103 11 , , , cord-263469-2w26l80a 103 12 2 2 CD cord-263469-2w26l80a 103 13 ) ) -RRB- cord-263469-2w26l80a 103 14 that that WDT cord-263469-2w26l80a 103 15 are be VBP cord-263469-2w26l80a 103 16 utilized utilize VBN cord-263469-2w26l80a 103 17 in in IN cord-263469-2w26l80a 103 18 infected infected JJ cord-263469-2w26l80a 103 19 cells cell NNS cord-263469-2w26l80a 103 20 to to TO cord-263469-2w26l80a 103 21 cleave cleave VB cord-263469-2w26l80a 103 22 the the DT cord-263469-2w26l80a 103 23 proteins protein NNS cord-263469-2w26l80a 103 24 into into IN cord-263469-2w26l80a 103 25 two two CD cord-263469-2w26l80a 103 26 subunits subunit NNS cord-263469-2w26l80a 103 27 GP1 gp1 NN cord-263469-2w26l80a 103 28 and and CC cord-263469-2w26l80a 103 29 GP2 GP2 NNP cord-263469-2w26l80a 103 30 [ [ -LRB- cord-263469-2w26l80a 103 31 11 11 CD cord-263469-2w26l80a 103 32 , , , cord-263469-2w26l80a 103 33 9 9 CD cord-263469-2w26l80a 103 34 ] ] -RRB- cord-263469-2w26l80a 103 35 . . . cord-263469-2w26l80a 104 1 Several several JJ cord-263469-2w26l80a 104 2 alphaherpesviruses alphaherpesviruse NNS cord-263469-2w26l80a 104 3 , , , cord-263469-2w26l80a 104 4 such such JJ cord-263469-2w26l80a 104 5 as as IN cord-263469-2w26l80a 104 6 varicella varicella NN cord-263469-2w26l80a 104 7 zoster zoster NN cord-263469-2w26l80a 104 8 virus virus NN cord-263469-2w26l80a 104 9 ( ( -LRB- cord-263469-2w26l80a 104 10 VZV VZV NNP cord-263469-2w26l80a 104 11 ) ) -RRB- cord-263469-2w26l80a 104 12 , , , cord-263469-2w26l80a 104 13 posses posse VBZ cord-263469-2w26l80a 104 14 a a DT cord-263469-2w26l80a 104 15 furin furin NN cord-263469-2w26l80a 104 16 cleavage cleavage NN cord-263469-2w26l80a 104 17 site site NN cord-263469-2w26l80a 104 18 in in IN cord-263469-2w26l80a 104 19 the the DT cord-263469-2w26l80a 104 20 analogous analogous JJ cord-263469-2w26l80a 104 21 location location NN cord-263469-2w26l80a 105 1 ( ( -LRB- cord-263469-2w26l80a 105 2 Fig Fig NNP cord-263469-2w26l80a 105 3 . . NNP cord-263469-2w26l80a 105 4 2 2 CD cord-263469-2w26l80a 105 5 dashed dash VBD cord-263469-2w26l80a 105 6 orange orange JJ cord-263469-2w26l80a 105 7 arrow arrow NN cord-263469-2w26l80a 105 8 ) ) -RRB- cord-263469-2w26l80a 105 9 . . . cord-263469-2w26l80a 106 1 Most Most JJS cord-263469-2w26l80a 106 2 beta beta NN cord-263469-2w26l80a 106 3 and and CC cord-263469-2w26l80a 106 4 gamma gamma NN cord-263469-2w26l80a 106 5 - - HYPH cord-263469-2w26l80a 106 6 herpesviruses herpesviruse NNS cord-263469-2w26l80a 106 7 , , , cord-263469-2w26l80a 106 8 Collinear Collinear NNP cord-263469-2w26l80a 106 9 arrangement arrangement NN cord-263469-2w26l80a 106 10 of of IN cord-263469-2w26l80a 106 11 similar similar JJ cord-263469-2w26l80a 106 12 structures structure NNS cord-263469-2w26l80a 106 13 in in IN cord-263469-2w26l80a 106 14 BDV BDV NNP cord-263469-2w26l80a 106 15 G G NNP cord-263469-2w26l80a 106 16 and and CC cord-263469-2w26l80a 106 17 VSV VSV NNP cord-263469-2w26l80a 106 18 G G NNP cord-263469-2w26l80a 106 19 Figure Figure NNP cord-263469-2w26l80a 106 20 1 1 CD cord-263469-2w26l80a 106 21 Collinear Collinear NNP cord-263469-2w26l80a 106 22 arrangement arrangement NN cord-263469-2w26l80a 106 23 of of IN cord-263469-2w26l80a 106 24 similar similar JJ cord-263469-2w26l80a 106 25 structures structure NNS cord-263469-2w26l80a 106 26 in in IN cord-263469-2w26l80a 106 27 BDV BDV NNP cord-263469-2w26l80a 106 28 G G NNP cord-263469-2w26l80a 106 29 and and CC cord-263469-2w26l80a 106 30 VSV VSV NNP cord-263469-2w26l80a 106 31 G. G. NNP cord-263469-2w26l80a 107 1 The the DT cord-263469-2w26l80a 107 2 post post JJ cord-263469-2w26l80a 107 3 fusion fusion NN cord-263469-2w26l80a 107 4 secondary secondary JJ cord-263469-2w26l80a 107 5 structure structure NN cord-263469-2w26l80a 107 6 of of IN cord-263469-2w26l80a 107 7 VSV VSV NNP cord-263469-2w26l80a 107 8 G G NNP cord-263469-2w26l80a 107 9 as as IN cord-263469-2w26l80a 107 10 solved solve VBN cord-263469-2w26l80a 107 11 and and CC cord-263469-2w26l80a 107 12 numbered number VBN cord-263469-2w26l80a 107 13 by by IN cord-263469-2w26l80a 107 14 Roche Roche NNP cord-263469-2w26l80a 107 15 and and CC cord-263469-2w26l80a 107 16 coworkers coworker NNS cord-263469-2w26l80a 107 17 [ [ -LRB- cord-263469-2w26l80a 107 18 30 30 CD cord-263469-2w26l80a 107 19 ] ] -RRB- cord-263469-2w26l80a 107 20 is be VBZ cord-263469-2w26l80a 107 21 depicted depict VBN cord-263469-2w26l80a 107 22 with with IN cord-263469-2w26l80a 107 23 α α NN cord-263469-2w26l80a 107 24 - - HYPH cord-263469-2w26l80a 107 25 helices helix NNS cord-263469-2w26l80a 107 26 as as IN cord-263469-2w26l80a 107 27 cylinders cylinder NNS cord-263469-2w26l80a 107 28 and and CC cord-263469-2w26l80a 107 29 β β NN cord-263469-2w26l80a 107 30 - - HYPH cord-263469-2w26l80a 107 31 sheets sheet NNS cord-263469-2w26l80a 107 32 as as IN cord-263469-2w26l80a 107 33 arrows arrow NNS cord-263469-2w26l80a 107 34 . . . cord-263469-2w26l80a 108 1 The the DT cord-263469-2w26l80a 108 2 α α NN cord-263469-2w26l80a 108 3 - - HYPH cord-263469-2w26l80a 108 4 helices helix NNS cord-263469-2w26l80a 108 5 predicted predict VBN cord-263469-2w26l80a 108 6 by by IN cord-263469-2w26l80a 108 7 PHD PHD NNP cord-263469-2w26l80a 109 1 In in IN cord-263469-2w26l80a 110 1 BDV BDV NNP cord-263469-2w26l80a 110 2 G G NNP cord-263469-2w26l80a 110 3 are be VBP cord-263469-2w26l80a 110 4 indicated indicate VBN cord-263469-2w26l80a 110 5 similarly similarly RB cord-263469-2w26l80a 110 6 . . . cord-263469-2w26l80a 111 1 β β NN cord-263469-2w26l80a 111 2 - - HYPH cord-263469-2w26l80a 111 3 sheets sheet NNS cord-263469-2w26l80a 111 4 ( ( -LRB- cord-263469-2w26l80a 111 5 t t NN cord-263469-2w26l80a 111 6 ) ) -RRB- cord-263469-2w26l80a 112 1 and and CC cord-263469-2w26l80a 112 2 ( ( -LRB- cord-263469-2w26l80a 112 3 u u NNP cord-263469-2w26l80a 112 4 ) ) -RRB- cord-263469-2w26l80a 112 5 of of IN cord-263469-2w26l80a 112 6 VSV VSV NNP cord-263469-2w26l80a 112 7 G G NNP cord-263469-2w26l80a 112 8 are be VBP cord-263469-2w26l80a 112 9 not not RB cord-263469-2w26l80a 112 10 present present JJ cord-263469-2w26l80a 112 11 in in IN cord-263469-2w26l80a 112 12 the the DT cord-263469-2w26l80a 112 13 protein protein NN cord-263469-2w26l80a 112 14 data data NN cord-263469-2w26l80a 112 15 base base NN cord-263469-2w26l80a 112 16 structure structure NN cord-263469-2w26l80a 112 17 ( ( -LRB- cord-263469-2w26l80a 112 18 2cmz.pdb 2cmz.pdb CD cord-263469-2w26l80a 112 19 ) ) -RRB- cord-263469-2w26l80a 112 20 . . . cord-263469-2w26l80a 113 1 In in IN cord-263469-2w26l80a 113 2 VSV VSV NNP cord-263469-2w26l80a 113 3 G G NNP cord-263469-2w26l80a 113 4 , , , cord-263469-2w26l80a 113 5 α α NN cord-263469-2w26l80a 113 6 - - HYPH cord-263469-2w26l80a 113 7 helices helix NNS cord-263469-2w26l80a 113 8 predicted predict VBN cord-263469-2w26l80a 113 9 by by IN cord-263469-2w26l80a 113 10 PHD PHD NNP cord-263469-2w26l80a 113 11 are be VBP cord-263469-2w26l80a 113 12 indicated indicate VBN cord-263469-2w26l80a 113 13 by by IN cord-263469-2w26l80a 113 14 dashed dash VBN cord-263469-2w26l80a 113 15 boxes box NNS cord-263469-2w26l80a 113 16 and and CC cord-263469-2w26l80a 113 17 predicted predict VBD cord-263469-2w26l80a 113 18 β β NN cord-263469-2w26l80a 113 19 - - HYPH cord-263469-2w26l80a 113 20 sheets sheet NNS cord-263469-2w26l80a 113 21 are be VBP cord-263469-2w26l80a 113 22 identified identify VBN cord-263469-2w26l80a 113 23 with with IN cord-263469-2w26l80a 113 24 dashed dash VBN cord-263469-2w26l80a 113 25 arrows arrow NNS cord-263469-2w26l80a 113 26 . . . cord-263469-2w26l80a 114 1 Amino amino NN cord-263469-2w26l80a 114 2 acids acid NNS cord-263469-2w26l80a 114 3 are be VBP cord-263469-2w26l80a 114 4 numbered number VBN cord-263469-2w26l80a 114 5 beginning begin VBG cord-263469-2w26l80a 114 6 after after IN cord-263469-2w26l80a 114 7 the the DT cord-263469-2w26l80a 114 8 putative putative JJ cord-263469-2w26l80a 114 9 signal signal NN cord-263469-2w26l80a 114 10 sequences sequence NNS cord-263469-2w26l80a 114 11 enclosed enclose VBN cord-263469-2w26l80a 114 12 in in IN cord-263469-2w26l80a 114 13 parentheses parenthesis NNS cord-263469-2w26l80a 114 14 . . . cord-263469-2w26l80a 115 1 Plum plum JJ cord-263469-2w26l80a 115 2 amino amino NN cord-263469-2w26l80a 115 3 acids acid NNS cord-263469-2w26l80a 115 4 : : : cord-263469-2w26l80a 115 5 N n CD cord-263469-2w26l80a 115 6 - - HYPH cord-263469-2w26l80a 115 7 glycosylation glycosylation NN cord-263469-2w26l80a 115 8 sites site NNS cord-263469-2w26l80a 115 9 . . . cord-263469-2w26l80a 116 1 Sequences sequence NNS cord-263469-2w26l80a 116 2 with with IN cord-263469-2w26l80a 116 3 significant significant JJ cord-263469-2w26l80a 116 4 WWIHS WWIHS NNP cord-263469-2w26l80a 116 5 scores score NNS cord-263469-2w26l80a 116 6 in in IN cord-263469-2w26l80a 116 7 the the DT cord-263469-2w26l80a 116 8 fusion fusion NN cord-263469-2w26l80a 116 9 domain domain NN cord-263469-2w26l80a 116 10 ( ( -LRB- cord-263469-2w26l80a 116 11 II II NNP cord-263469-2w26l80a 116 12 ) ) -RRB- cord-263469-2w26l80a 116 13 were be VBD cord-263469-2w26l80a 116 14 identified identify VBN cord-263469-2w26l80a 116 15 by by IN cord-263469-2w26l80a 116 16 MPeX MPeX NNP cord-263469-2w26l80a 116 17 and and CC cord-263469-2w26l80a 116 18 colored colored JJ cord-263469-2w26l80a 116 19 red red NN cord-263469-2w26l80a 116 20 . . . cord-263469-2w26l80a 117 1 Hydrophobic hydrophobic JJ cord-263469-2w26l80a 117 2 transmembrane transmembrane NN cord-263469-2w26l80a 117 3 domains domain NNS cord-263469-2w26l80a 117 4 ( ( -LRB- cord-263469-2w26l80a 117 5 violet violet NN cord-263469-2w26l80a 117 6 ) ) -RRB- cord-263469-2w26l80a 117 7 were be VBD cord-263469-2w26l80a 117 8 predicted predict VBN cord-263469-2w26l80a 117 9 using use VBG cord-263469-2w26l80a 117 10 TMpred TMpred NNP cord-263469-2w26l80a 117 11 . . . cord-263469-2w26l80a 118 1 A a DT cord-263469-2w26l80a 118 2 class class NN cord-263469-2w26l80a 118 3 III iii CD cord-263469-2w26l80a 118 4 domain domain NN cord-263469-2w26l80a 118 5 nomenclature nomenclature NN cord-263469-2w26l80a 118 6 is be VBZ cord-263469-2w26l80a 118 7 used use VBN cord-263469-2w26l80a 118 8 here here RB cord-263469-2w26l80a 118 9 that that WDT cord-263469-2w26l80a 118 10 can can MD cord-263469-2w26l80a 118 11 apply apply VB cord-263469-2w26l80a 118 12 to to IN cord-263469-2w26l80a 118 13 both both DT cord-263469-2w26l80a 118 14 class class NN cord-263469-2w26l80a 118 15 II II NNP cord-263469-2w26l80a 118 16 and and CC cord-263469-2w26l80a 118 17 III iii CD cord-263469-2w26l80a 118 18 VFP VFP NNP cord-263469-2w26l80a 118 19 : : : cord-263469-2w26l80a 119 1 domain domain NN cord-263469-2w26l80a 119 2 I -PRON- PRP cord-263469-2w26l80a 119 3 ( ( -LRB- cord-263469-2w26l80a 119 4 green green JJ cord-263469-2w26l80a 119 5 ) ) -RRB- cord-263469-2w26l80a 119 6 , , , cord-263469-2w26l80a 119 7 domain domain NN cord-263469-2w26l80a 119 8 II II NNP cord-263469-2w26l80a 119 9 ( ( -LRB- cord-263469-2w26l80a 119 10 yellow yellow NNP cord-263469-2w26l80a 119 11 ) ) -RRB- cord-263469-2w26l80a 119 12 , , , cord-263469-2w26l80a 119 13 domain domain NN cord-263469-2w26l80a 119 14 III III NNP cord-263469-2w26l80a 119 15 ( ( -LRB- cord-263469-2w26l80a 119 16 blue blue NNP cord-263469-2w26l80a 119 17 ) ) -RRB- cord-263469-2w26l80a 119 18 , , , cord-263469-2w26l80a 119 19 and and CC cord-263469-2w26l80a 119 20 stem stem NN cord-263469-2w26l80a 119 21 domain domain NN cord-263469-2w26l80a 119 22 ( ( -LRB- cord-263469-2w26l80a 119 23 indigo indigo NN cord-263469-2w26l80a 119 24 ) ) -RRB- cord-263469-2w26l80a 119 25 . . . cord-263469-2w26l80a 120 1 This this DT cord-263469-2w26l80a 120 2 unified unified JJ cord-263469-2w26l80a 120 3 nomenclature nomenclature NN cord-263469-2w26l80a 120 4 assigns assign VBZ cord-263469-2w26l80a 120 5 domain domain NN cord-263469-2w26l80a 120 6 II II NNP cord-263469-2w26l80a 120 7 ( ( -LRB- cord-263469-2w26l80a 120 8 IV IV NNP cord-263469-2w26l80a 120 9 in in IN cord-263469-2w26l80a 120 10 the the DT cord-263469-2w26l80a 120 11 VSV VSV NNP cord-263469-2w26l80a 120 12 G G NNP cord-263469-2w26l80a 120 13 nomenclature nomenclature NN cord-263469-2w26l80a 120 14 of of IN cord-263469-2w26l80a 120 15 Roche Roche NNP cord-263469-2w26l80a 120 16 et et NNP cord-263469-2w26l80a 120 17 al al NNP cord-263469-2w26l80a 120 18 . . . cord-263469-2w26l80a 121 1 [ [ -LRB- cord-263469-2w26l80a 121 2 30 30 CD cord-263469-2w26l80a 121 3 ] ] -RRB- cord-263469-2w26l80a 121 4 , , , cord-263469-2w26l80a 121 5 I -PRON- PRP cord-263469-2w26l80a 121 6 in in IN cord-263469-2w26l80a 121 7 the the DT cord-263469-2w26l80a 121 8 HSV-1 HSV-1 NNP cord-263469-2w26l80a 121 9 gB gB NNP cord-263469-2w26l80a 121 10 nomenclature nomenclature NN cord-263469-2w26l80a 121 11 of of IN cord-263469-2w26l80a 121 12 Heldwein Heldwein NNP cord-263469-2w26l80a 121 13 et et NNP cord-263469-2w26l80a 121 14 al al NNP cord-263469-2w26l80a 121 15 . . . cord-263469-2w26l80a 122 1 [ [ -LRB- cord-263469-2w26l80a 122 2 32 32 CD cord-263469-2w26l80a 122 3 ] ] -RRB- cord-263469-2w26l80a 122 4 and and CC cord-263469-2w26l80a 122 5 Ia Ia NNP cord-263469-2w26l80a 122 6 and and CC cord-263469-2w26l80a 122 7 Ib Ib NNP cord-263469-2w26l80a 122 8 in in IN cord-263469-2w26l80a 122 9 the the DT cord-263469-2w26l80a 122 10 baculovirus baculovirus NNP cord-263469-2w26l80a 122 11 nomenclature nomenclature NN cord-263469-2w26l80a 122 12 of of IN cord-263469-2w26l80a 122 13 Kadlec Kadlec NNP cord-263469-2w26l80a 122 14 et et NNP cord-263469-2w26l80a 122 15 al al NNP cord-263469-2w26l80a 122 16 . . . cord-263469-2w26l80a 123 1 [ [ -LRB- cord-263469-2w26l80a 123 2 34 34 CD cord-263469-2w26l80a 123 3 ] ] -RRB- cord-263469-2w26l80a 123 4 ) ) -RRB- cord-263469-2w26l80a 123 5 as as IN cord-263469-2w26l80a 123 6 the the DT cord-263469-2w26l80a 123 7 class class NN cord-263469-2w26l80a 123 8 III iii CD cord-263469-2w26l80a 123 9 fusion fusion NN cord-263469-2w26l80a 123 10 domain domain NN cord-263469-2w26l80a 123 11 as as IN cord-263469-2w26l80a 123 12 in in IN cord-263469-2w26l80a 123 13 class class NN cord-263469-2w26l80a 123 14 II II NNP cord-263469-2w26l80a 123 15 VFPs vfp NNS cord-263469-2w26l80a 123 16 . . . cord-263469-2w26l80a 124 1 In in IN cord-263469-2w26l80a 124 2 addition addition NN cord-263469-2w26l80a 124 3 to to IN cord-263469-2w26l80a 124 4 minor minor JJ cord-263469-2w26l80a 124 5 adjustments adjustment NNS cord-263469-2w26l80a 124 6 in in IN cord-263469-2w26l80a 124 7 the the DT cord-263469-2w26l80a 124 8 ends end NNS cord-263469-2w26l80a 124 9 of of IN cord-263469-2w26l80a 124 10 domains domain NNS cord-263469-2w26l80a 124 11 , , , cord-263469-2w26l80a 124 12 the the DT cord-263469-2w26l80a 124 13 current current JJ cord-263469-2w26l80a 124 14 class class NN cord-263469-2w26l80a 124 15 III iii CD cord-263469-2w26l80a 124 16 VFP vfp NN cord-263469-2w26l80a 124 17 numbering number VBG cord-263469-2w26l80a 124 18 also also RB cord-263469-2w26l80a 124 19 combines combine VBZ cord-263469-2w26l80a 124 20 two two CD cord-263469-2w26l80a 124 21 interacting interact VBG cord-263469-2w26l80a 124 22 domains domain NNS cord-263469-2w26l80a 124 23 into into IN cord-263469-2w26l80a 124 24 domain domain NN cord-263469-2w26l80a 124 25 III iii CD cord-263469-2w26l80a 124 26 ( ( -LRB- cord-263469-2w26l80a 124 27 I i NN cord-263469-2w26l80a 124 28 + + CC cord-263469-2w26l80a 124 29 II II NNP cord-263469-2w26l80a 124 30 in in IN cord-263469-2w26l80a 124 31 Roche Roche NNP cord-263469-2w26l80a 124 32 's 's POS cord-263469-2w26l80a 124 33 VSV VSV NNP cord-263469-2w26l80a 124 34 G G NNP cord-263469-2w26l80a 124 35 nomenclature nomenclature NN cord-263469-2w26l80a 124 36 , , , cord-263469-2w26l80a 124 37 III III NNP cord-263469-2w26l80a 124 38 + + CC cord-263469-2w26l80a 124 39 IV IV NNP cord-263469-2w26l80a 124 40 in in IN cord-263469-2w26l80a 124 41 Heldwein Heldwein NNP cord-263469-2w26l80a 124 42 's 's POS cord-263469-2w26l80a 124 43 HSV-1 hsv-1 NN cord-263469-2w26l80a 124 44 gB gB NNP cord-263469-2w26l80a 124 45 nomenclature nomenclature NN cord-263469-2w26l80a 124 46 and and CC cord-263469-2w26l80a 124 47 Kadlec Kadlec NNP cord-263469-2w26l80a 124 48 's 's POS cord-263469-2w26l80a 124 49 baculovirus baculovirus NN cord-263469-2w26l80a 124 50 nomenclature nomenclature NN cord-263469-2w26l80a 124 51 ) ) -RRB- cord-263469-2w26l80a 124 52 . . . cord-263469-2w26l80a 125 1 The the DT cord-263469-2w26l80a 125 2 domain domain NN cord-263469-2w26l80a 125 3 numbering number VBG cord-263469-2w26l80a 125 4 originally originally RB cord-263469-2w26l80a 125 5 proposed propose VBN cord-263469-2w26l80a 125 6 is be VBZ cord-263469-2w26l80a 125 7 also also RB cord-263469-2w26l80a 125 8 indicated indicate VBN cord-263469-2w26l80a 125 9 . . . cord-263469-2w26l80a 126 1 UA UA NNP cord-263469-2w26l80a 126 2 represents represent VBZ cord-263469-2w26l80a 126 3 " " `` cord-263469-2w26l80a 126 4 hinge hinge NN cord-263469-2w26l80a 126 5 " " '' cord-263469-2w26l80a 126 6 aa aa NNP cord-263469-2w26l80a 126 7 not not RB cord-263469-2w26l80a 126 8 assigned assign VBN cord-263469-2w26l80a 126 9 to to IN cord-263469-2w26l80a 126 10 domains domain NNS cord-263469-2w26l80a 126 11 in in IN cord-263469-2w26l80a 126 12 VSV VSV NNP cord-263469-2w26l80a 126 13 G G NNP cord-263469-2w26l80a 126 14 in in IN cord-263469-2w26l80a 126 15 the the DT cord-263469-2w26l80a 126 16 prior prior JJ cord-263469-2w26l80a 126 17 scheme scheme NN cord-263469-2w26l80a 126 18 . . . cord-263469-2w26l80a 127 1 including include VBG cord-263469-2w26l80a 127 2 CMV CMV NNP cord-263469-2w26l80a 127 3 and and CC cord-263469-2w26l80a 127 4 EBV EBV NNP cord-263469-2w26l80a 127 5 , , , cord-263469-2w26l80a 127 6 have have VBP cord-263469-2w26l80a 127 7 a a DT cord-263469-2w26l80a 127 8 furin furin NN cord-263469-2w26l80a 127 9 cleavage cleavage NN cord-263469-2w26l80a 127 10 site site NN cord-263469-2w26l80a 127 11 prior prior RB cord-263469-2w26l80a 127 12 to to IN cord-263469-2w26l80a 127 13 the the DT cord-263469-2w26l80a 127 14 extended extended JJ cord-263469-2w26l80a 127 15 α α NN cord-263469-2w26l80a 127 16 - - HYPH cord-263469-2w26l80a 127 17 helix helix NN cord-263469-2w26l80a 127 18 . . . cord-263469-2w26l80a 128 1 Therefore therefore RB cord-263469-2w26l80a 128 2 , , , cord-263469-2w26l80a 128 3 possession possession NN cord-263469-2w26l80a 128 4 of of IN cord-263469-2w26l80a 128 5 a a DT cord-263469-2w26l80a 128 6 furin furin NN cord-263469-2w26l80a 128 7 cleavage cleavage NN cord-263469-2w26l80a 128 8 site site NN cord-263469-2w26l80a 128 9 does do VBZ cord-263469-2w26l80a 128 10 not not RB cord-263469-2w26l80a 128 11 preclude preclude VB cord-263469-2w26l80a 128 12 the the DT cord-263469-2w26l80a 128 13 possibility possibility NN cord-263469-2w26l80a 128 14 that that IN cord-263469-2w26l80a 128 15 BDV BDV NNP cord-263469-2w26l80a 128 16 GP GP NNP cord-263469-2w26l80a 128 17 is be VBZ cord-263469-2w26l80a 128 18 a a DT cord-263469-2w26l80a 128 19 class class NN cord-263469-2w26l80a 128 20 III iii NN cord-263469-2w26l80a 128 21 VFP vfp NN cord-263469-2w26l80a 128 22 . . . cord-263469-2w26l80a 129 1 Cysteine cysteine NN cord-263469-2w26l80a 129 2 residues residue NNS cord-263469-2w26l80a 129 3 are be VBP cord-263469-2w26l80a 129 4 usually usually RB cord-263469-2w26l80a 129 5 the the DT cord-263469-2w26l80a 129 6 most most RBS cord-263469-2w26l80a 129 7 conserved conserved JJ cord-263469-2w26l80a 129 8 aa aa NN cord-263469-2w26l80a 129 9 within within IN cord-263469-2w26l80a 129 10 a a DT cord-263469-2w26l80a 129 11 protein protein NN cord-263469-2w26l80a 129 12 family family NN cord-263469-2w26l80a 129 13 because because IN cord-263469-2w26l80a 129 14 disulfide disulfide JJ cord-263469-2w26l80a 129 15 bonds bond NNS cord-263469-2w26l80a 129 16 between between IN cord-263469-2w26l80a 129 17 cysteines cysteine NNS cord-263469-2w26l80a 129 18 are be VBP cord-263469-2w26l80a 129 19 critical critical JJ cord-263469-2w26l80a 129 20 determinants determinant NNS cord-263469-2w26l80a 129 21 of of IN cord-263469-2w26l80a 129 22 secondary secondary JJ cord-263469-2w26l80a 129 23 structure structure NN cord-263469-2w26l80a 129 24 . . . cord-263469-2w26l80a 130 1 The the DT cord-263469-2w26l80a 130 2 cysteines cysteine NNS cord-263469-2w26l80a 130 3 of of IN cord-263469-2w26l80a 130 4 class class NN cord-263469-2w26l80a 130 5 III III NNP cord-263469-2w26l80a 130 6 ( ( -LRB- cord-263469-2w26l80a 130 7 and and CC cord-263469-2w26l80a 130 8 class class NN cord-263469-2w26l80a 130 9 II II NNP cord-263469-2w26l80a 130 10 ) ) -RRB- cord-263469-2w26l80a 130 11 VFPs vfp NNS cord-263469-2w26l80a 130 12 determined determine VBN cord-263469-2w26l80a 130 13 by by IN cord-263469-2w26l80a 130 14 X x NN cord-263469-2w26l80a 130 15 - - NN cord-263469-2w26l80a 130 16 ray ray NN cord-263469-2w26l80a 130 17 crystallography crystallography NN cord-263469-2w26l80a 130 18 are be VBP cord-263469-2w26l80a 130 19 arranged arrange VBN cord-263469-2w26l80a 130 20 such such PDT cord-263469-2w26l80a 130 21 that that IN cord-263469-2w26l80a 130 22 disulfide disulfide JJ cord-263469-2w26l80a 130 23 bonds bond NNS cord-263469-2w26l80a 130 24 are be VBP cord-263469-2w26l80a 130 25 formed form VBN cord-263469-2w26l80a 130 26 between between IN cord-263469-2w26l80a 130 27 cysteine cysteine NN cord-263469-2w26l80a 130 28 residues residue NNS cord-263469-2w26l80a 130 29 within within IN cord-263469-2w26l80a 130 30 the the DT cord-263469-2w26l80a 130 31 same same JJ cord-263469-2w26l80a 130 32 domain domain NN cord-263469-2w26l80a 130 33 . . . cord-263469-2w26l80a 131 1 To to TO cord-263469-2w26l80a 131 2 determine determine VB cord-263469-2w26l80a 131 3 the the DT cord-263469-2w26l80a 131 4 plausibility plausibility NN cord-263469-2w26l80a 131 5 of of IN cord-263469-2w26l80a 131 6 the the DT cord-263469-2w26l80a 131 7 proposed propose VBN cord-263469-2w26l80a 131 8 alignment alignment NN cord-263469-2w26l80a 131 9 , , , cord-263469-2w26l80a 131 10 a a DT cord-263469-2w26l80a 131 11 model model NN cord-263469-2w26l80a 131 12 of of IN cord-263469-2w26l80a 131 13 BDV BDV NNP cord-263469-2w26l80a 131 14 G G NNP cord-263469-2w26l80a 131 15 scaffolded scaffold VBN cord-263469-2w26l80a 131 16 on on IN cord-263469-2w26l80a 131 17 the the DT cord-263469-2w26l80a 131 18 structure structure NN cord-263469-2w26l80a 131 19 of of IN cord-263469-2w26l80a 131 20 VSV VSV NNP cord-263469-2w26l80a 131 21 G G NNP cord-263469-2w26l80a 131 22 in in IN cord-263469-2w26l80a 131 23 the the DT cord-263469-2w26l80a 131 24 post post JJ cord-263469-2w26l80a 131 25 - - JJ cord-263469-2w26l80a 131 26 fusion fusion JJ cord-263469-2w26l80a 131 27 ( ( -LRB- cord-263469-2w26l80a 131 28 low low JJ cord-263469-2w26l80a 131 29 pH ph NN cord-263469-2w26l80a 131 30 ) ) -RRB- cord-263469-2w26l80a 131 31 configuration configuration NN cord-263469-2w26l80a 131 32 [ [ -LRB- cord-263469-2w26l80a 131 33 30 30 CD cord-263469-2w26l80a 131 34 ] ] -RRB- cord-263469-2w26l80a 131 35 was be VBD cord-263469-2w26l80a 131 36 constructed construct VBN cord-263469-2w26l80a 131 37 ( ( -LRB- cord-263469-2w26l80a 131 38 Fig Fig NNP cord-263469-2w26l80a 131 39 . . . cord-263469-2w26l80a 131 40 3 3 CD cord-263469-2w26l80a 131 41 ) ) -RRB- cord-263469-2w26l80a 131 42 . . . cord-263469-2w26l80a 132 1 The the DT cord-263469-2w26l80a 132 2 alignment alignment NN cord-263469-2w26l80a 132 3 between between IN cord-263469-2w26l80a 132 4 VSV VSV NNP cord-263469-2w26l80a 132 5 and and CC cord-263469-2w26l80a 132 6 BDV BDV NNP cord-263469-2w26l80a 132 7 G G NNP cord-263469-2w26l80a 132 8 suggest suggest VBP cord-263469-2w26l80a 132 9 that that IN cord-263469-2w26l80a 132 10 these these DT cord-263469-2w26l80a 132 11 VFPs vfp NNS cord-263469-2w26l80a 132 12 may may MD cord-263469-2w26l80a 132 13 have have VB cord-263469-2w26l80a 132 14 a a DT cord-263469-2w26l80a 132 15 similar similar JJ cord-263469-2w26l80a 132 16 structure structure NN cord-263469-2w26l80a 132 17 . . . cord-263469-2w26l80a 133 1 Therefore therefore RB cord-263469-2w26l80a 133 2 , , , cord-263469-2w26l80a 133 3 putative putative JJ cord-263469-2w26l80a 133 4 structures structure NNS cord-263469-2w26l80a 133 5 in in IN cord-263469-2w26l80a 133 6 BDV BDV NNP cord-263469-2w26l80a 133 7 G G NNP cord-263469-2w26l80a 133 8 are be VBP cord-263469-2w26l80a 133 9 depicted depict VBN cord-263469-2w26l80a 133 10 as as IN cord-263469-2w26l80a 133 11 in in IN cord-263469-2w26l80a 133 12 VSV VSV NNP cord-263469-2w26l80a 133 13 G. G. NNP cord-263469-2w26l80a 134 1 The the DT cord-263469-2w26l80a 134 2 proposed propose VBN cord-263469-2w26l80a 134 3 BDV BDV NNP cord-263469-2w26l80a 134 4 G G NNP cord-263469-2w26l80a 134 5 model model NN cord-263469-2w26l80a 134 6 is be VBZ cord-263469-2w26l80a 134 7 based base VBN cord-263469-2w26l80a 134 8 principally principally RB cord-263469-2w26l80a 134 9 on on IN cord-263469-2w26l80a 134 10 the the DT cord-263469-2w26l80a 134 11 structural structural JJ cord-263469-2w26l80a 134 12 predictions prediction NNS cord-263469-2w26l80a 134 13 of of IN cord-263469-2w26l80a 134 14 PHD PHD NNP cord-263469-2w26l80a 134 15 , , , cord-263469-2w26l80a 134 16 the the DT cord-263469-2w26l80a 134 17 most most RBS cord-263469-2w26l80a 134 18 robust robust JJ cord-263469-2w26l80a 134 19 secondary secondary JJ cord-263469-2w26l80a 134 20 structure structure NN cord-263469-2w26l80a 134 21 prediction prediction NN cord-263469-2w26l80a 134 22 algorithm algorithm NN cord-263469-2w26l80a 134 23 used use VBN cord-263469-2w26l80a 134 24 . . . cord-263469-2w26l80a 135 1 These these DT cord-263469-2w26l80a 135 2 results result NNS cord-263469-2w26l80a 135 3 provide provide VBP cord-263469-2w26l80a 135 4 evidence evidence NN cord-263469-2w26l80a 135 5 that that IN cord-263469-2w26l80a 135 6 the the DT cord-263469-2w26l80a 135 7 10 10 CD cord-263469-2w26l80a 135 8 cysteines cysteine NNS cord-263469-2w26l80a 135 9 in in IN cord-263469-2w26l80a 135 10 the the DT cord-263469-2w26l80a 135 11 putative putative JJ cord-263469-2w26l80a 135 12 fusion fusion NN cord-263469-2w26l80a 135 13 domain domain NN cord-263469-2w26l80a 135 14 ( ( -LRB- cord-263469-2w26l80a 135 15 domain domain NN cord-263469-2w26l80a 135 16 II ii CD cord-263469-2w26l80a 135 17 ) ) -RRB- cord-263469-2w26l80a 135 18 can can MD cord-263469-2w26l80a 135 19 potentially potentially RB cord-263469-2w26l80a 135 20 bond bond NN cord-263469-2w26l80a 135 21 . . . cord-263469-2w26l80a 136 1 Such such JJ cord-263469-2w26l80a 136 2 linkages linkage NNS cord-263469-2w26l80a 136 3 can can MD cord-263469-2w26l80a 136 4 stabilize stabilize VB cord-263469-2w26l80a 136 5 the the DT cord-263469-2w26l80a 136 6 fusion fusion NN cord-263469-2w26l80a 136 7 loops loop NNS cord-263469-2w26l80a 136 8 as as IN cord-263469-2w26l80a 136 9 occurs occur NNS cord-263469-2w26l80a 136 10 in in IN cord-263469-2w26l80a 136 11 both both DT cord-263469-2w26l80a 136 12 class class NN cord-263469-2w26l80a 136 13 II II NNP cord-263469-2w26l80a 136 14 and and CC cord-263469-2w26l80a 136 15 III iii CD cord-263469-2w26l80a 136 16 VFP VFP NNP cord-263469-2w26l80a 136 17 . . . cord-263469-2w26l80a 137 1 The the DT cord-263469-2w26l80a 137 2 dicysteine dicysteine JJ cord-263469-2w26l80a 137 3 linkages linkage NNS cord-263469-2w26l80a 137 4 are be VBP cord-263469-2w26l80a 137 5 modeled model VBN cord-263469-2w26l80a 137 6 such such JJ cord-263469-2w26l80a 137 7 that that IN cord-263469-2w26l80a 137 8 all all DT cord-263469-2w26l80a 137 9 cysteine cysteine NN cord-263469-2w26l80a 137 10 bonding bonding NN cord-263469-2w26l80a 137 11 occurs occur VBZ cord-263469-2w26l80a 137 12 between between IN cord-263469-2w26l80a 137 13 the the DT cord-263469-2w26l80a 137 14 putative putative JJ cord-263469-2w26l80a 137 15 domains domain NNS cord-263469-2w26l80a 137 16 , , , cord-263469-2w26l80a 137 17 as as IN cord-263469-2w26l80a 137 18 is be VBZ cord-263469-2w26l80a 137 19 the the DT cord-263469-2w26l80a 137 20 case case NN cord-263469-2w26l80a 137 21 with with IN cord-263469-2w26l80a 137 22 other other JJ cord-263469-2w26l80a 137 23 class class NN cord-263469-2w26l80a 137 24 III iii CD cord-263469-2w26l80a 137 25 VFP VFP NNP cord-263469-2w26l80a 137 26 . . . cord-263469-2w26l80a 138 1 Fig Fig NNP cord-263469-2w26l80a 138 2 . . . cord-263469-2w26l80a 139 1 1 1 LS cord-263469-2w26l80a 139 2 . . . cord-263469-2w26l80a 140 1 Amino amino NN cord-263469-2w26l80a 140 2 acids acid NNS cord-263469-2w26l80a 140 3 are be VBP cord-263469-2w26l80a 140 4 numbered number VBN cord-263469-2w26l80a 140 5 beginning begin VBG cord-263469-2w26l80a 140 6 after after IN cord-263469-2w26l80a 140 7 the the DT cord-263469-2w26l80a 140 8 putative putative JJ cord-263469-2w26l80a 140 9 signal signal NN cord-263469-2w26l80a 140 10 sequences sequence NNS cord-263469-2w26l80a 140 11 in in IN cord-263469-2w26l80a 140 12 VSV VSV NNP cord-263469-2w26l80a 140 13 G G NNP cord-263469-2w26l80a 140 14 , , , cord-263469-2w26l80a 140 15 but but CC cord-263469-2w26l80a 140 16 at at IN cord-263469-2w26l80a 140 17 the the DT cord-263469-2w26l80a 140 18 beginning beginning NN cord-263469-2w26l80a 140 19 of of IN cord-263469-2w26l80a 140 20 the the DT cord-263469-2w26l80a 140 21 signal signal JJ cord-263469-2w26l80a 140 22 sequence sequence NN cord-263469-2w26l80a 140 23 of of IN cord-263469-2w26l80a 140 24 HSV-1 HSV-1 NNP cord-263469-2w26l80a 140 25 gB. gB. NNP cord-263469-2w26l80a 140 26 Arrows Arrows NNP cord-263469-2w26l80a 140 27 indicate indicate VBP cord-263469-2w26l80a 140 28 G G NNP cord-263469-2w26l80a 140 29 and and CC cord-263469-2w26l80a 140 30 gB gB NNP cord-263469-2w26l80a 140 31 truncations truncation NNS cord-263469-2w26l80a 140 32 of of IN cord-263469-2w26l80a 140 33 the the DT cord-263469-2w26l80a 140 34 forms form NNS cord-263469-2w26l80a 140 35 used use VBN cord-263469-2w26l80a 140 36 for for IN cord-263469-2w26l80a 140 37 crystallography crystallography NN cord-263469-2w26l80a 140 38 . . . cord-263469-2w26l80a 141 1 Solid solid JJ cord-263469-2w26l80a 141 2 lines line NNS cord-263469-2w26l80a 141 3 represent represent VBP cord-263469-2w26l80a 141 4 cysteine cysteine NN cord-263469-2w26l80a 141 5 bonding bonding NN cord-263469-2w26l80a 141 6 in in IN cord-263469-2w26l80a 141 7 VSV VSV NNP cord-263469-2w26l80a 141 8 G G NNP cord-263469-2w26l80a 141 9 , , , cord-263469-2w26l80a 141 10 AcMNPV acmnpv NN cord-263469-2w26l80a 141 11 GP64 GP64 NNP cord-263469-2w26l80a 141 12 , , , cord-263469-2w26l80a 141 13 and and CC cord-263469-2w26l80a 141 14 HSV-1 HSV-1 NNP cord-263469-2w26l80a 141 15 and and CC cord-263469-2w26l80a 141 16 EBV EBV NNP cord-263469-2w26l80a 141 17 gB gB NNP cord-263469-2w26l80a 141 18 [ [ -LRB- cord-263469-2w26l80a 141 19 30 30 CD cord-263469-2w26l80a 141 20 , , , cord-263469-2w26l80a 141 21 32 32 CD cord-263469-2w26l80a 141 22 , , , cord-263469-2w26l80a 141 23 34 34 CD cord-263469-2w26l80a 141 24 , , , cord-263469-2w26l80a 141 25 43 43 CD cord-263469-2w26l80a 141 26 ] ] -RRB- cord-263469-2w26l80a 141 27 . . . cord-263469-2w26l80a 142 1 Black black JJ cord-263469-2w26l80a 142 2 boxes box NNS cord-263469-2w26l80a 142 3 represent represent VBP cord-263469-2w26l80a 142 4 hydrophobic hydrophobic JJ cord-263469-2w26l80a 142 5 regions region NNS cord-263469-2w26l80a 142 6 , , , cord-263469-2w26l80a 142 7 with with IN cord-263469-2w26l80a 142 8 violet violet NN cord-263469-2w26l80a 142 9 representing represent VBG cord-263469-2w26l80a 142 10 the the DT cord-263469-2w26l80a 142 11 transmembrane transmembrane NN cord-263469-2w26l80a 142 12 anchor anchor NN cord-263469-2w26l80a 142 13 ( ( -LRB- cord-263469-2w26l80a 142 14 TM TM NNP cord-263469-2w26l80a 142 15 ) ) -RRB- cord-263469-2w26l80a 142 16 . . . cord-263469-2w26l80a 143 1 Dashed dash VBN cord-263469-2w26l80a 143 2 lines line NNS cord-263469-2w26l80a 143 3 represent represent VBP cord-263469-2w26l80a 143 4 potential potential JJ cord-263469-2w26l80a 143 5 cysteine cysteine NN cord-263469-2w26l80a 143 6 bonding bonding NN cord-263469-2w26l80a 143 7 in in IN cord-263469-2w26l80a 143 8 BDV BDV NNP cord-263469-2w26l80a 143 9 G G NNP cord-263469-2w26l80a 143 10 , , , cord-263469-2w26l80a 143 11 THOV THOV NNP cord-263469-2w26l80a 143 12 GP GP NNP cord-263469-2w26l80a 143 13 and and CC cord-263469-2w26l80a 143 14 CMV CMV NNP cord-263469-2w26l80a 143 15 gB. gb. NN cord-263469-2w26l80a 144 1 Dashed dash VBN cord-263469-2w26l80a 144 2 arrow arrow NN cord-263469-2w26l80a 144 3 is be VBZ cord-263469-2w26l80a 144 4 the the DT cord-263469-2w26l80a 144 5 location location NN cord-263469-2w26l80a 144 6 of of IN cord-263469-2w26l80a 144 7 a a DT cord-263469-2w26l80a 144 8 furin furin NN cord-263469-2w26l80a 144 9 cleavage cleavage NN cord-263469-2w26l80a 144 10 site site NN cord-263469-2w26l80a 144 11 in in IN cord-263469-2w26l80a 144 12 the the DT cord-263469-2w26l80a 144 13 alphaherpesvirus alphaherpesvirus NNP cord-263469-2w26l80a 144 14 varicella varicella NNP cord-263469-2w26l80a 144 15 zoster zoster NNP cord-263469-2w26l80a 144 16 virus virus NN cord-263469-2w26l80a 144 17 ( ( -LRB- cord-263469-2w26l80a 144 18 human human JJ cord-263469-2w26l80a 144 19 herpes herpes NNP cord-263469-2w26l80a 144 20 virus virus NN cord-263469-2w26l80a 144 21 3 3 CD cord-263469-2w26l80a 144 22 ) ) -RRB- cord-263469-2w26l80a 144 23 . . . cord-263469-2w26l80a 145 1 Solid solid JJ cord-263469-2w26l80a 145 2 arrows arrow NNS cord-263469-2w26l80a 145 3 are be VBP cord-263469-2w26l80a 145 4 furin furin NN cord-263469-2w26l80a 145 5 cleavage cleavage NN cord-263469-2w26l80a 145 6 sites site NNS cord-263469-2w26l80a 145 7 in in IN cord-263469-2w26l80a 145 8 BDV BDV NNP cord-263469-2w26l80a 145 9 G G NNP cord-263469-2w26l80a 145 10 , , , cord-263469-2w26l80a 145 11 CMV CMV NNP cord-263469-2w26l80a 145 12 gB gB NNP cord-263469-2w26l80a 145 13 , , , cord-263469-2w26l80a 145 14 and and CC cord-263469-2w26l80a 145 15 EBV EBV NNP cord-263469-2w26l80a 145 16 gB. gB. NNP cord-263469-2w26l80a 146 1 After after IN cord-263469-2w26l80a 146 2 cleavage cleavage NN cord-263469-2w26l80a 146 3 by by IN cord-263469-2w26l80a 146 4 furin furin NN cord-263469-2w26l80a 146 5 GP1 GP1 NNP cord-263469-2w26l80a 146 6 and and CC cord-263469-2w26l80a 146 7 GP2 GP2 NNP cord-263469-2w26l80a 146 8 of of IN cord-263469-2w26l80a 146 9 BDV BDV NNP cord-263469-2w26l80a 146 10 appear appear VBP cord-263469-2w26l80a 146 11 not not RB cord-263469-2w26l80a 146 12 to to TO cord-263469-2w26l80a 146 13 be be VB cord-263469-2w26l80a 146 14 linked link VBN cord-263469-2w26l80a 146 15 by by IN cord-263469-2w26l80a 146 16 covalent covalent JJ cord-263469-2w26l80a 146 17 bonding bonding NN cord-263469-2w26l80a 146 18 , , , cord-263469-2w26l80a 146 19 as as IN cord-263469-2w26l80a 146 20 the the DT cord-263469-2w26l80a 146 21 subunits subunit NNS cord-263469-2w26l80a 146 22 disassociate disassociate VBP cord-263469-2w26l80a 146 23 during during IN cord-263469-2w26l80a 146 24 SDS SDS NNP cord-263469-2w26l80a 146 25 - - HYPH cord-263469-2w26l80a 146 26 PAGE PAGE NNP cord-263469-2w26l80a 146 27 [ [ -LRB- cord-263469-2w26l80a 146 28 9 9 CD cord-263469-2w26l80a 146 29 ] ] -RRB- cord-263469-2w26l80a 146 30 . . . cord-263469-2w26l80a 147 1 Therefore therefore RB cord-263469-2w26l80a 147 2 , , , cord-263469-2w26l80a 147 3 we -PRON- PRP cord-263469-2w26l80a 147 4 have have VBP cord-263469-2w26l80a 147 5 not not RB cord-263469-2w26l80a 147 6 modeled model VBN cord-263469-2w26l80a 147 7 any any DT cord-263469-2w26l80a 147 8 dicysteine dicysteine JJ cord-263469-2w26l80a 147 9 linkages linkage NNS cord-263469-2w26l80a 147 10 between between IN cord-263469-2w26l80a 147 11 the the DT cord-263469-2w26l80a 147 12 GP1 GP1 NNP cord-263469-2w26l80a 147 13 and and CC cord-263469-2w26l80a 147 14 GP2 GP2 NNP cord-263469-2w26l80a 147 15 subunits subunit NNS cord-263469-2w26l80a 147 16 . . . cord-263469-2w26l80a 148 1 There there EX cord-263469-2w26l80a 148 2 are be VBP cord-263469-2w26l80a 148 3 plausible plausible JJ cord-263469-2w26l80a 148 4 intradomain intradomain NN cord-263469-2w26l80a 148 5 linkages linkage NNS cord-263469-2w26l80a 148 6 that that WDT cord-263469-2w26l80a 148 7 can can MD cord-263469-2w26l80a 148 8 form form VB cord-263469-2w26l80a 148 9 between between IN cord-263469-2w26l80a 148 10 each each DT cord-263469-2w26l80a 148 11 of of IN cord-263469-2w26l80a 148 12 the the DT cord-263469-2w26l80a 148 13 cysteines cysteine NNS cord-263469-2w26l80a 148 14 in in IN cord-263469-2w26l80a 148 15 BDV BDV NNP cord-263469-2w26l80a 148 16 G. G. NNP cord-263469-2w26l80a 149 1 The the DT cord-263469-2w26l80a 149 2 BDV BDV NNP cord-263469-2w26l80a 149 3 G G NNP cord-263469-2w26l80a 149 4 structural structural JJ cord-263469-2w26l80a 149 5 model model NN cord-263469-2w26l80a 149 6 presented present VBN cord-263469-2w26l80a 149 7 here here RB cord-263469-2w26l80a 149 8 is be VBZ cord-263469-2w26l80a 149 9 not not RB cord-263469-2w26l80a 149 10 intended intend VBN cord-263469-2w26l80a 149 11 as as IN cord-263469-2w26l80a 149 12 a a DT cord-263469-2w26l80a 149 13 definitive definitive JJ cord-263469-2w26l80a 149 14 structural structural JJ cord-263469-2w26l80a 149 15 prediction prediction NN cord-263469-2w26l80a 149 16 . . . cord-263469-2w26l80a 150 1 Rather rather RB cord-263469-2w26l80a 150 2 , , , cord-263469-2w26l80a 150 3 there there EX cord-263469-2w26l80a 150 4 are be VBP cord-263469-2w26l80a 150 5 many many JJ cord-263469-2w26l80a 150 6 possible possible JJ cord-263469-2w26l80a 150 7 alternatives alternative NNS cord-263469-2w26l80a 150 8 to to IN cord-263469-2w26l80a 150 9 the the DT cord-263469-2w26l80a 150 10 secondary secondary JJ cord-263469-2w26l80a 150 11 and and CC cord-263469-2w26l80a 150 12 tertiary tertiary JJ cord-263469-2w26l80a 150 13 structures structure NNS cord-263469-2w26l80a 150 14 and and CC cord-263469-2w26l80a 150 15 the the DT cord-263469-2w26l80a 150 16 cysteine cysteine NN cord-263469-2w26l80a 150 17 linkages linkage NNS cord-263469-2w26l80a 150 18 of of IN cord-263469-2w26l80a 150 19 BDV BDV NNP cord-263469-2w26l80a 150 20 G. G. NNP cord-263469-2w26l80a 151 1 For for IN cord-263469-2w26l80a 151 2 example example NN cord-263469-2w26l80a 151 3 , , , cord-263469-2w26l80a 151 4 it -PRON- PRP cord-263469-2w26l80a 151 5 is be VBZ cord-263469-2w26l80a 151 6 possible possible JJ cord-263469-2w26l80a 151 7 that that IN cord-263469-2w26l80a 151 8 in in IN cord-263469-2w26l80a 151 9 a a DT cord-263469-2w26l80a 151 10 minor minor JJ cord-263469-2w26l80a 151 11 subset subset NN cord-263469-2w26l80a 151 12 of of IN cord-263469-2w26l80a 151 13 G g NN cord-263469-2w26l80a 151 14 may may MD cord-263469-2w26l80a 151 15 be be VB cord-263469-2w26l80a 151 16 cross cros VBN cord-263469-2w26l80a 151 17 - - VBN cord-263469-2w26l80a 151 18 linked link VBN cord-263469-2w26l80a 151 19 via via IN cord-263469-2w26l80a 151 20 cysteine cysteine NN cord-263469-2w26l80a 151 21 binding binding NN cord-263469-2w26l80a 151 22 such such JJ cord-263469-2w26l80a 151 23 that that IN cord-263469-2w26l80a 151 24 the the DT cord-263469-2w26l80a 151 25 GP1 gp1 NN cord-263469-2w26l80a 151 26 and and CC cord-263469-2w26l80a 151 27 2 2 CD cord-263469-2w26l80a 151 28 subunits subunit NNS cord-263469-2w26l80a 151 29 are be VBP cord-263469-2w26l80a 151 30 covalently covalently RB cord-263469-2w26l80a 151 31 bound bind VBN cord-263469-2w26l80a 151 32 . . . cord-263469-2w26l80a 152 1 The the DT cord-263469-2w26l80a 152 2 modeling modeling NN cord-263469-2w26l80a 152 3 does do VBZ cord-263469-2w26l80a 152 4 establish establish VB cord-263469-2w26l80a 152 5 that that DT cord-263469-2w26l80a 152 6 feasible feasible JJ cord-263469-2w26l80a 152 7 structures structure NNS cord-263469-2w26l80a 152 8 exist exist VBP cord-263469-2w26l80a 152 9 that that WDT cord-263469-2w26l80a 152 10 are be VBP cord-263469-2w26l80a 152 11 consistent consistent JJ cord-263469-2w26l80a 152 12 with with IN cord-263469-2w26l80a 152 13 the the DT cord-263469-2w26l80a 152 14 secondary secondary JJ cord-263469-2w26l80a 152 15 structure structure NN cord-263469-2w26l80a 152 16 predictions prediction NNS cord-263469-2w26l80a 152 17 and and CC cord-263469-2w26l80a 152 18 with with IN cord-263469-2w26l80a 152 19 the the DT cord-263469-2w26l80a 152 20 assignment assignment NN cord-263469-2w26l80a 152 21 of of IN cord-263469-2w26l80a 152 22 BDV BDV NNP cord-263469-2w26l80a 152 23 G G NNP cord-263469-2w26l80a 152 24 as as IN cord-263469-2w26l80a 152 25 a a DT cord-263469-2w26l80a 152 26 class class NN cord-263469-2w26l80a 152 27 III iii NN cord-263469-2w26l80a 152 28 VFP vfp NN cord-263469-2w26l80a 152 29 . . . cord-263469-2w26l80a 153 1 Proteomics Proteomics NNP cord-263469-2w26l80a 153 2 computational computational JJ cord-263469-2w26l80a 153 3 analyses analysis NNS cord-263469-2w26l80a 153 4 suggest suggest VBP cord-263469-2w26l80a 153 5 that that IN cord-263469-2w26l80a 153 6 bornavirus bornavirus NNP cord-263469-2w26l80a 153 7 G G NNP cord-263469-2w26l80a 153 8 are be VBP cord-263469-2w26l80a 153 9 class class NN cord-263469-2w26l80a 153 10 III iii NN cord-263469-2w26l80a 153 11 VFP VFP NNP cord-263469-2w26l80a 153 12 . . . cord-263469-2w26l80a 154 1 Computational computational JJ cord-263469-2w26l80a 154 2 analyses analysis NNS cord-263469-2w26l80a 154 3 and and CC cord-263469-2w26l80a 154 4 other other JJ cord-263469-2w26l80a 154 5 methods method NNS cord-263469-2w26l80a 154 6 predict predict VBP cord-263469-2w26l80a 154 7 that that IN cord-263469-2w26l80a 154 8 each each DT cord-263469-2w26l80a 154 9 of of IN cord-263469-2w26l80a 154 10 the the DT cord-263469-2w26l80a 154 11 major major JJ cord-263469-2w26l80a 154 12 features feature NNS cord-263469-2w26l80a 154 13 common common JJ cord-263469-2w26l80a 154 14 to to IN cord-263469-2w26l80a 154 15 class class NN cord-263469-2w26l80a 154 16 III iii CD cord-263469-2w26l80a 154 17 fusion fusion NN cord-263469-2w26l80a 154 18 proteins protein NNS cord-263469-2w26l80a 154 19 are be VBP cord-263469-2w26l80a 154 20 present present JJ cord-263469-2w26l80a 154 21 in in IN cord-263469-2w26l80a 154 22 BVD BVD NNP cord-263469-2w26l80a 154 23 G G NNP cord-263469-2w26l80a 154 24 , , , cord-263469-2w26l80a 154 25 including include VBG cord-263469-2w26l80a 154 26 internal internal JJ cord-263469-2w26l80a 154 27 fusion fusion NN cord-263469-2w26l80a 154 28 loops loop NNS cord-263469-2w26l80a 154 29 , , , cord-263469-2w26l80a 154 30 an an DT cord-263469-2w26l80a 154 31 extended extended JJ cord-263469-2w26l80a 154 32 α α NNP cord-263469-2w26l80a 154 33 helical helical JJ cord-263469-2w26l80a 154 34 domain domain NN cord-263469-2w26l80a 154 35 , , , cord-263469-2w26l80a 154 36 a a DT cord-263469-2w26l80a 154 37 stem stem NN cord-263469-2w26l80a 154 38 domain domain NN cord-263469-2w26l80a 154 39 and and CC cord-263469-2w26l80a 154 40 a a DT cord-263469-2w26l80a 154 41 carboxyl carboxyl NN cord-263469-2w26l80a 154 42 terminal terminal NN cord-263469-2w26l80a 154 43 transmembrane transmembrane NN cord-263469-2w26l80a 154 44 domain domain NN cord-263469-2w26l80a 154 45 . . . cord-263469-2w26l80a 155 1 These these DT cord-263469-2w26l80a 155 2 features feature NNS cord-263469-2w26l80a 155 3 of of IN cord-263469-2w26l80a 155 4 BDV BDV NNP cord-263469-2w26l80a 155 5 G G NNP cord-263469-2w26l80a 155 6 are be VBP cord-263469-2w26l80a 155 7 located locate VBN cord-263469-2w26l80a 155 8 collinearly collinearly RB cord-263469-2w26l80a 155 9 with with IN cord-263469-2w26l80a 155 10 those those DT cord-263469-2w26l80a 155 11 of of IN cord-263469-2w26l80a 155 12 VSV VSV NNP cord-263469-2w26l80a 155 13 G G NNP cord-263469-2w26l80a 155 14 , , , cord-263469-2w26l80a 155 15 a a DT cord-263469-2w26l80a 155 16 prototypic prototypic JJ cord-263469-2w26l80a 155 17 class class NN cord-263469-2w26l80a 155 18 III III NNP cord-263469-2w26l80a 155 19 VFP VFP NNP cord-263469-2w26l80a 155 20 [ [ -LRB- cord-263469-2w26l80a 155 21 30 30 CD cord-263469-2w26l80a 155 22 , , , cord-263469-2w26l80a 155 23 31 31 CD cord-263469-2w26l80a 155 24 ] ] -RRB- cord-263469-2w26l80a 155 25 . . . cord-263469-2w26l80a 156 1 On on IN cord-263469-2w26l80a 156 2 the the DT cord-263469-2w26l80a 156 3 basis basis NN cord-263469-2w26l80a 156 4 of of IN cord-263469-2w26l80a 156 5 sequence sequence NN cord-263469-2w26l80a 156 6 similarities similarity NNS cord-263469-2w26l80a 156 7 amongst amongst IN cord-263469-2w26l80a 156 8 G g NN cord-263469-2w26l80a 156 9 of of IN cord-263469-2w26l80a 156 10 members member NNS cord-263469-2w26l80a 156 11 of of IN cord-263469-2w26l80a 156 12 the the DT cord-263469-2w26l80a 156 13 Bornaviridae Bornaviridae NNP cord-263469-2w26l80a 156 14 it -PRON- PRP cord-263469-2w26l80a 156 15 is be VBZ cord-263469-2w26l80a 156 16 likely likely JJ cord-263469-2w26l80a 156 17 that that IN cord-263469-2w26l80a 156 18 all all DT cord-263469-2w26l80a 156 19 are be VBP cord-263469-2w26l80a 156 20 class class NN cord-263469-2w26l80a 156 21 III III NNP cord-263469-2w26l80a 156 22 VFP VFP NNP cord-263469-2w26l80a 156 23 . . . cord-263469-2w26l80a 157 1 Structural structural JJ cord-263469-2w26l80a 157 2 models model NNS cord-263469-2w26l80a 157 3 including include VBG cord-263469-2w26l80a 157 4 feasible feasible JJ cord-263469-2w26l80a 157 5 cysteine cysteine NN cord-263469-2w26l80a 157 6 linkage linkage NN cord-263469-2w26l80a 157 7 maps map NNS cord-263469-2w26l80a 157 8 could could MD cord-263469-2w26l80a 157 9 be be VB cord-263469-2w26l80a 157 10 readily readily RB cord-263469-2w26l80a 157 11 established establish VBN cord-263469-2w26l80a 157 12 for for IN cord-263469-2w26l80a 157 13 BDV BDV NNP cord-263469-2w26l80a 157 14 G G NNP cord-263469-2w26l80a 157 15 using use VBG cord-263469-2w26l80a 157 16 the the DT cord-263469-2w26l80a 157 17 VSV VSV NNP cord-263469-2w26l80a 157 18 G G NNP cord-263469-2w26l80a 157 19 post post JJ cord-263469-2w26l80a 157 20 - - JJ cord-263469-2w26l80a 157 21 fusion fusion JJ cord-263469-2w26l80a 157 22 structure structure NN cord-263469-2w26l80a 157 23 as as IN cord-263469-2w26l80a 157 24 a a DT cord-263469-2w26l80a 157 25 scaffold scaffold NN cord-263469-2w26l80a 157 26 . . . cord-263469-2w26l80a 158 1 The the DT cord-263469-2w26l80a 158 2 fusion fusion NN cord-263469-2w26l80a 158 3 domains domain NNS cord-263469-2w26l80a 158 4 of of IN cord-263469-2w26l80a 158 5 BVD BVD NNP cord-263469-2w26l80a 158 6 G G NNP cord-263469-2w26l80a 158 7 , , , cord-263469-2w26l80a 158 8 which which WDT cord-263469-2w26l80a 158 9 we -PRON- PRP cord-263469-2w26l80a 158 10 refer refer VBP cord-263469-2w26l80a 158 11 to to IN cord-263469-2w26l80a 158 12 here here RB cord-263469-2w26l80a 158 13 in in IN cord-263469-2w26l80a 158 14 a a DT cord-263469-2w26l80a 158 15 unified unified JJ cord-263469-2w26l80a 158 16 domain domain NN cord-263469-2w26l80a 158 17 nomenclature nomenclature NN cord-263469-2w26l80a 158 18 as as IN cord-263469-2w26l80a 158 19 domain domain NN cord-263469-2w26l80a 158 20 II II NNP cord-263469-2w26l80a 158 21 , , , cord-263469-2w26l80a 158 22 appear appear VBP cord-263469-2w26l80a 158 23 to to TO cord-263469-2w26l80a 158 24 be be VB cord-263469-2w26l80a 158 25 stabilized stabilize VBN cord-263469-2w26l80a 158 26 by by IN cord-263469-2w26l80a 158 27 cysteine cysteine NN cord-263469-2w26l80a 158 28 bonds bond NNS cord-263469-2w26l80a 158 29 and and CC cord-263469-2w26l80a 158 30 to to TO cord-263469-2w26l80a 158 31 contain contain VB cord-263469-2w26l80a 158 32 one one CD cord-263469-2w26l80a 158 33 or or CC cord-263469-2w26l80a 158 34 more more JJR cord-263469-2w26l80a 158 35 loops loop NNS cord-263469-2w26l80a 158 36 Model Model NNP cord-263469-2w26l80a 158 37 of of IN cord-263469-2w26l80a 158 38 BDV BDV NNP cord-263469-2w26l80a 158 39 G G NNP cord-263469-2w26l80a 158 40 based base VBN cord-263469-2w26l80a 158 41 on on IN cord-263469-2w26l80a 158 42 the the DT cord-263469-2w26l80a 158 43 X x NN cord-263469-2w26l80a 158 44 - - NN cord-263469-2w26l80a 158 45 ray ray JJ cord-263469-2w26l80a 158 46 crystallographic crystallographic JJ cord-263469-2w26l80a 158 47 structure structure NN cord-263469-2w26l80a 158 48 of of IN cord-263469-2w26l80a 158 49 VSV VSV NNP cord-263469-2w26l80a 158 50 G G NNP cord-263469-2w26l80a 158 51 Figure Figure NNP cord-263469-2w26l80a 158 52 3 3 CD cord-263469-2w26l80a 158 53 Model Model NNP cord-263469-2w26l80a 158 54 of of IN cord-263469-2w26l80a 158 55 BDV BDV NNP cord-263469-2w26l80a 158 56 G G NNP cord-263469-2w26l80a 158 57 based base VBN cord-263469-2w26l80a 158 58 on on IN cord-263469-2w26l80a 158 59 the the DT cord-263469-2w26l80a 158 60 X x NN cord-263469-2w26l80a 158 61 - - NN cord-263469-2w26l80a 158 62 ray ray JJ cord-263469-2w26l80a 158 63 crystallographic crystallographic JJ cord-263469-2w26l80a 158 64 structure structure NN cord-263469-2w26l80a 158 65 of of IN cord-263469-2w26l80a 158 66 VSV VSV NNP cord-263469-2w26l80a 158 67 G. G. NNP cord-263469-2w26l80a 159 1 The the DT cord-263469-2w26l80a 159 2 predicted predict VBN cord-263469-2w26l80a 159 3 structures structure NNS cord-263469-2w26l80a 159 4 of of IN cord-263469-2w26l80a 159 5 BDV BDV NNP cord-263469-2w26l80a 159 6 G G NNP cord-263469-2w26l80a 159 7 was be VBD cord-263469-2w26l80a 159 8 fit fit JJ cord-263469-2w26l80a 159 9 to to IN cord-263469-2w26l80a 159 10 the the DT cord-263469-2w26l80a 159 11 post post JJ cord-263469-2w26l80a 159 12 - - JJ cord-263469-2w26l80a 159 13 fusion fusion JJ cord-263469-2w26l80a 159 14 structure structure NN cord-263469-2w26l80a 159 15 of of IN cord-263469-2w26l80a 159 16 VSV VSV NNP cord-263469-2w26l80a 159 17 G G NNP cord-263469-2w26l80a 159 18 [ [ -LRB- cord-263469-2w26l80a 159 19 30 30 CD cord-263469-2w26l80a 159 20 ] ] -RRB- cord-263469-2w26l80a 159 21 . . . cord-263469-2w26l80a 160 1 The the DT cord-263469-2w26l80a 160 2 post post JJ cord-263469-2w26l80a 160 3 fusion fusion NN cord-263469-2w26l80a 160 4 secondary secondary JJ cord-263469-2w26l80a 160 5 structure structure NN cord-263469-2w26l80a 160 6 of of IN cord-263469-2w26l80a 160 7 VSV VSV NNP cord-263469-2w26l80a 160 8 G G NNP cord-263469-2w26l80a 160 9 as as IN cord-263469-2w26l80a 160 10 solved solve VBN cord-263469-2w26l80a 160 11 by by IN cord-263469-2w26l80a 160 12 Roche Roche NNP cord-263469-2w26l80a 160 13 and and CC cord-263469-2w26l80a 160 14 coworkers coworker NNS cord-263469-2w26l80a 160 15 [ [ -LRB- cord-263469-2w26l80a 160 16 30 30 CD cord-263469-2w26l80a 160 17 ] ] -RRB- cord-263469-2w26l80a 160 18 is be VBZ cord-263469-2w26l80a 160 19 depicted depict VBN cord-263469-2w26l80a 160 20 with with IN cord-263469-2w26l80a 160 21 α α NN cord-263469-2w26l80a 160 22 - - HYPH cord-263469-2w26l80a 160 23 helices helix NNS cord-263469-2w26l80a 160 24 as as IN cord-263469-2w26l80a 160 25 cylinders cylinder NNS cord-263469-2w26l80a 160 26 and and CC cord-263469-2w26l80a 160 27 β β NN cord-263469-2w26l80a 160 28 - - HYPH cord-263469-2w26l80a 160 29 sheets sheet NNS cord-263469-2w26l80a 160 30 as as IN cord-263469-2w26l80a 160 31 arrows arrow NNS cord-263469-2w26l80a 160 32 . . . cord-263469-2w26l80a 161 1 β β NN cord-263469-2w26l80a 161 2 - - HYPH cord-263469-2w26l80a 161 3 sheets sheet NNS cord-263469-2w26l80a 161 4 ( ( -LRB- cord-263469-2w26l80a 161 5 t t NN cord-263469-2w26l80a 161 6 ) ) -RRB- cord-263469-2w26l80a 162 1 and and CC cord-263469-2w26l80a 162 2 ( ( -LRB- cord-263469-2w26l80a 162 3 u u NNP cord-263469-2w26l80a 162 4 ) ) -RRB- cord-263469-2w26l80a 162 5 of of IN cord-263469-2w26l80a 162 6 VSV VSV NNP cord-263469-2w26l80a 162 7 G G NNP cord-263469-2w26l80a 162 8 are be VBP cord-263469-2w26l80a 162 9 not not RB cord-263469-2w26l80a 162 10 present present JJ cord-263469-2w26l80a 162 11 in in IN cord-263469-2w26l80a 162 12 the the DT cord-263469-2w26l80a 162 13 protein protein NN cord-263469-2w26l80a 162 14 data data NN cord-263469-2w26l80a 162 15 base base NN cord-263469-2w26l80a 162 16 structure structure NN cord-263469-2w26l80a 162 17 ( ( -LRB- cord-263469-2w26l80a 162 18 2cmz.pdb 2cmz.pdb CD cord-263469-2w26l80a 162 19 ) ) -RRB- cord-263469-2w26l80a 162 20 . . . cord-263469-2w26l80a 163 1 Sequences sequence NNS cord-263469-2w26l80a 163 2 with with IN cord-263469-2w26l80a 163 3 significant significant JJ cord-263469-2w26l80a 163 4 WWIHS WWIHS NNP cord-263469-2w26l80a 163 5 scores score NNS cord-263469-2w26l80a 163 6 were be VBD cord-263469-2w26l80a 163 7 identified identify VBN cord-263469-2w26l80a 163 8 by by IN cord-263469-2w26l80a 163 9 MPeX MPeX NNP cord-263469-2w26l80a 163 10 and and CC cord-263469-2w26l80a 163 11 filled fill VBN cord-263469-2w26l80a 163 12 red red JJ cord-263469-2w26l80a 163 13 or or CC cord-263469-2w26l80a 163 14 outlined outline VBN cord-263469-2w26l80a 163 15 with with IN cord-263469-2w26l80a 163 16 red red JJ cord-263469-2w26l80a 163 17 lines line NNS cord-263469-2w26l80a 163 18 . . . cord-263469-2w26l80a 164 1 Hydrophobic hydrophobic JJ cord-263469-2w26l80a 164 2 transmembrane transmembrane NN cord-263469-2w26l80a 164 3 domains domain NNS cord-263469-2w26l80a 164 4 ( ( -LRB- cord-263469-2w26l80a 164 5 violet violet NN cord-263469-2w26l80a 164 6 ) ) -RRB- cord-263469-2w26l80a 164 7 were be VBD cord-263469-2w26l80a 164 8 predicted predict VBN cord-263469-2w26l80a 164 9 using use VBG cord-263469-2w26l80a 164 10 TMpred TMpred NNP cord-263469-2w26l80a 164 11 as as IN cord-263469-2w26l80a 164 12 discussed discuss VBN cord-263469-2w26l80a 164 13 in in IN cord-263469-2w26l80a 164 14 the the DT cord-263469-2w26l80a 164 15 text text NN cord-263469-2w26l80a 164 16 . . . cord-263469-2w26l80a 165 1 Secondary secondary JJ cord-263469-2w26l80a 165 2 structures structure NNS cord-263469-2w26l80a 165 3 for for IN cord-263469-2w26l80a 165 4 BDV BDV NNP cord-263469-2w26l80a 165 5 G G NNP cord-263469-2w26l80a 165 6 were be VBD cord-263469-2w26l80a 165 7 predicted predict VBN cord-263469-2w26l80a 165 8 by by IN cord-263469-2w26l80a 165 9 PHD PHD NNP cord-263469-2w26l80a 165 10 . . . cord-263469-2w26l80a 166 1 Orange Orange NNP cord-263469-2w26l80a 166 2 / / SYM cord-263469-2w26l80a 166 3 black black JJ cord-263469-2w26l80a 166 4 lines line NNS cord-263469-2w26l80a 166 5 : : : cord-263469-2w26l80a 166 6 dicysteine dicysteine NNP cord-263469-2w26l80a 166 7 linkages linkage NNS cord-263469-2w26l80a 166 8 . . . cord-263469-2w26l80a 167 1 Black black JJ cord-263469-2w26l80a 167 2 stick stick NN cord-263469-2w26l80a 167 3 figures figure NNS cord-263469-2w26l80a 167 4 : : : cord-263469-2w26l80a 167 5 N n CD cord-263469-2w26l80a 167 6 - - HYPH cord-263469-2w26l80a 167 7 glycosylation glycosylation NN cord-263469-2w26l80a 167 8 sites site NNS cord-263469-2w26l80a 167 9 . . . cord-263469-2w26l80a 168 1 with with IN cord-263469-2w26l80a 168 2 positive positive JJ cord-263469-2w26l80a 168 3 WWIHS WWIHS NNP cord-263469-2w26l80a 168 4 scores score NNS cord-263469-2w26l80a 168 5 , , , cord-263469-2w26l80a 168 6 features feature VBZ cord-263469-2w26l80a 168 7 characteristic characteristic NN cord-263469-2w26l80a 168 8 of of IN cord-263469-2w26l80a 168 9 the the DT cord-263469-2w26l80a 168 10 fusion fusion NN cord-263469-2w26l80a 168 11 domains domain NNS cord-263469-2w26l80a 168 12 of of IN cord-263469-2w26l80a 168 13 both both DT cord-263469-2w26l80a 168 14 class class NN cord-263469-2w26l80a 168 15 II II NNP cord-263469-2w26l80a 168 16 and and CC cord-263469-2w26l80a 168 17 III iii CD cord-263469-2w26l80a 168 18 VFP VFP NNP cord-263469-2w26l80a 168 19 . . . cord-263469-2w26l80a 169 1 Differences difference NNS cord-263469-2w26l80a 169 2 between between IN cord-263469-2w26l80a 169 3 VSV VSV NNP cord-263469-2w26l80a 169 4 and and CC cord-263469-2w26l80a 169 5 BDV BDV NNP cord-263469-2w26l80a 169 6 G G NNP cord-263469-2w26l80a 169 7 include include VBP cord-263469-2w26l80a 169 8 the the DT cord-263469-2w26l80a 169 9 presence presence NN cord-263469-2w26l80a 169 10 of of IN cord-263469-2w26l80a 169 11 a a DT cord-263469-2w26l80a 169 12 consensus consensus NN cord-263469-2w26l80a 169 13 furin furin NN cord-263469-2w26l80a 169 14 cleavage cleavage NN cord-263469-2w26l80a 169 15 site site NN cord-263469-2w26l80a 169 16 and and CC cord-263469-2w26l80a 169 17 a a DT cord-263469-2w26l80a 169 18 higher high JJR cord-263469-2w26l80a 169 19 number number NN cord-263469-2w26l80a 169 20 of of IN cord-263469-2w26l80a 169 21 N n CD cord-263469-2w26l80a 169 22 - - HYPH cord-263469-2w26l80a 169 23 glycosylation glycosylation NN cord-263469-2w26l80a 169 24 sites site NNS cord-263469-2w26l80a 169 25 in in IN cord-263469-2w26l80a 169 26 BDV BDV NNP cord-263469-2w26l80a 169 27 G. G. NNP cord-263469-2w26l80a 170 1 However however RB cord-263469-2w26l80a 170 2 , , , cord-263469-2w26l80a 170 3 many many JJ cord-263469-2w26l80a 170 4 herpesvirus herpesvirus NN cord-263469-2w26l80a 170 5 gB gB NNP cord-263469-2w26l80a 170 6 , , , cord-263469-2w26l80a 170 7 which which WDT cord-263469-2w26l80a 170 8 are be VBP cord-263469-2w26l80a 170 9 class class NN cord-263469-2w26l80a 170 10 III III NNP cord-263469-2w26l80a 170 11 VFP VFP NNP cord-263469-2w26l80a 170 12 , , , cord-263469-2w26l80a 170 13 contain contain VBP cord-263469-2w26l80a 170 14 a a DT cord-263469-2w26l80a 170 15 furin furin NN cord-263469-2w26l80a 170 16 cleavage cleavage NN cord-263469-2w26l80a 170 17 domain domain NN cord-263469-2w26l80a 170 18 prior prior RB cord-263469-2w26l80a 170 19 to to IN cord-263469-2w26l80a 170 20 the the DT cord-263469-2w26l80a 170 21 extended extended JJ cord-263469-2w26l80a 170 22 α α NNP cord-263469-2w26l80a 170 23 helix helix NN cord-263469-2w26l80a 170 24 in in IN cord-263469-2w26l80a 170 25 domain domain NN cord-263469-2w26l80a 170 26 III III NNP cord-263469-2w26l80a 170 27 and and CC cord-263469-2w26l80a 170 28 are be VBP cord-263469-2w26l80a 170 29 more more RBR cord-263469-2w26l80a 170 30 heavily heavily RB cord-263469-2w26l80a 170 31 glycosylated glycosylate VBN cord-263469-2w26l80a 170 32 than than IN cord-263469-2w26l80a 170 33 VSV VSV NNP cord-263469-2w26l80a 170 34 G. G. NNP cord-263469-2w26l80a 171 1 Therefore therefore RB cord-263469-2w26l80a 171 2 , , , cord-263469-2w26l80a 171 3 the the DT cord-263469-2w26l80a 171 4 presence presence NN cord-263469-2w26l80a 171 5 of of IN cord-263469-2w26l80a 171 6 the the DT cord-263469-2w26l80a 171 7 furin furin NN cord-263469-2w26l80a 171 8 cleavage cleavage NN cord-263469-2w26l80a 171 9 site site NN cord-263469-2w26l80a 171 10 and and CC cord-263469-2w26l80a 171 11 high high JJ cord-263469-2w26l80a 171 12 glycan glycan NN cord-263469-2w26l80a 171 13 content content NN cord-263469-2w26l80a 171 14 in in IN cord-263469-2w26l80a 171 15 BDV BDV NNP cord-263469-2w26l80a 171 16 G G NNP cord-263469-2w26l80a 171 17 does do VBZ cord-263469-2w26l80a 171 18 not not RB cord-263469-2w26l80a 171 19 preclude preclude VB cord-263469-2w26l80a 171 20 its -PRON- PRP$ cord-263469-2w26l80a 171 21 putative putative JJ cord-263469-2w26l80a 171 22 inclusion inclusion NN cord-263469-2w26l80a 171 23 in in IN cord-263469-2w26l80a 171 24 class class NN cord-263469-2w26l80a 171 25 III III NNP cord-263469-2w26l80a 171 26 . . . cord-263469-2w26l80a 172 1 Whether whether IN cord-263469-2w26l80a 172 2 or or CC cord-263469-2w26l80a 172 3 not not RB cord-263469-2w26l80a 172 4 the the DT cord-263469-2w26l80a 172 5 secondary secondary JJ cord-263469-2w26l80a 172 6 and and CC cord-263469-2w26l80a 172 7 tertiary tertiary JJ cord-263469-2w26l80a 172 8 folding folding NN cord-263469-2w26l80a 172 9 of of IN cord-263469-2w26l80a 172 10 BDV BDV NNP cord-263469-2w26l80a 172 11 GP GP NNP cord-263469-2w26l80a 172 12 conforms conform VBZ cord-263469-2w26l80a 172 13 to to IN cord-263469-2w26l80a 172 14 the the DT cord-263469-2w26l80a 172 15 domain domain NN cord-263469-2w26l80a 172 16 structure structure NN cord-263469-2w26l80a 172 17 of of IN cord-263469-2w26l80a 172 18 class class NN cord-263469-2w26l80a 172 19 III III NNP cord-263469-2w26l80a 172 20 VFP VFP NNP cord-263469-2w26l80a 172 21 will will MD cord-263469-2w26l80a 172 22 require require VB cord-263469-2w26l80a 172 23 x x NN cord-263469-2w26l80a 172 24 - - NN cord-263469-2w26l80a 172 25 ray ray NN cord-263469-2w26l80a 172 26 crystallographic crystallographic JJ cord-263469-2w26l80a 172 27 or or CC cord-263469-2w26l80a 172 28 other other JJ cord-263469-2w26l80a 172 29 physical physical JJ cord-263469-2w26l80a 172 30 structural structural JJ cord-263469-2w26l80a 172 31 determinations determination NNS cord-263469-2w26l80a 172 32 . . . cord-263469-2w26l80a 173 1 The the DT cord-263469-2w26l80a 173 2 three three CD cord-263469-2w26l80a 173 3 VFP VFP NNP cord-263469-2w26l80a 173 4 classes class NNS cord-263469-2w26l80a 173 5 for for IN cord-263469-2w26l80a 173 6 enveloped envelop VBN cord-263469-2w26l80a 173 7 virus virus NN cord-263469-2w26l80a 173 8 membrane membrane NN cord-263469-2w26l80a 173 9 glycoproteins glycoprotein NNS cord-263469-2w26l80a 173 10 were be VBD cord-263469-2w26l80a 173 11 established establish VBN cord-263469-2w26l80a 173 12 based base VBN cord-263469-2w26l80a 173 13 on on IN cord-263469-2w26l80a 173 14 structural structural JJ cord-263469-2w26l80a 173 15 similarities similarity NNS cord-263469-2w26l80a 173 16 in in IN cord-263469-2w26l80a 173 17 the the DT cord-263469-2w26l80a 173 18 post post JJ cord-263469-2w26l80a 173 19 - - JJ cord-263469-2w26l80a 173 20 fusion fusion JJ cord-263469-2w26l80a 173 21 configurations configuration NNS cord-263469-2w26l80a 173 22 . . . cord-263469-2w26l80a 174 1 Therefore therefore RB cord-263469-2w26l80a 174 2 , , , cord-263469-2w26l80a 174 3 it -PRON- PRP cord-263469-2w26l80a 174 4 is be VBZ cord-263469-2w26l80a 174 5 likely likely JJ cord-263469-2w26l80a 174 6 that that IN cord-263469-2w26l80a 174 7 there there EX cord-263469-2w26l80a 174 8 is be VBZ cord-263469-2w26l80a 174 9 a a DT cord-263469-2w26l80a 174 10 common common JJ cord-263469-2w26l80a 174 11 post post JJ cord-263469-2w26l80a 174 12 - - JJ cord-263469-2w26l80a 174 13 fusion fusion JJ cord-263469-2w26l80a 174 14 ( ( -LRB- cord-263469-2w26l80a 174 15 low low JJ cord-263469-2w26l80a 174 16 pH ph NN cord-263469-2w26l80a 174 17 ) ) -RRB- cord-263469-2w26l80a 174 18 configuration configuration NN cord-263469-2w26l80a 174 19 of of IN cord-263469-2w26l80a 174 20 class class NN cord-263469-2w26l80a 174 21 III III NNP cord-263469-2w26l80a 174 22 VFP VFP NNP cord-263469-2w26l80a 174 23 , , , cord-263469-2w26l80a 174 24 and and CC cord-263469-2w26l80a 174 25 that that IN cord-263469-2w26l80a 174 26 BDV BDV NNP cord-263469-2w26l80a 174 27 G G NNP cord-263469-2w26l80a 174 28 has have VBZ cord-263469-2w26l80a 174 29 a a DT cord-263469-2w26l80a 174 30 post post JJ cord-263469-2w26l80a 174 31 - - JJ cord-263469-2w26l80a 174 32 fusion fusion JJ cord-263469-2w26l80a 174 33 structure structure NN cord-263469-2w26l80a 174 34 similar similar JJ cord-263469-2w26l80a 174 35 to to IN cord-263469-2w26l80a 174 36 VSV VSV NNP cord-263469-2w26l80a 174 37 G. G. NNP cord-263469-2w26l80a 175 1 In in IN cord-263469-2w26l80a 175 2 contrast contrast NN cord-263469-2w26l80a 175 3 , , , cord-263469-2w26l80a 175 4 the the DT cord-263469-2w26l80a 175 5 prefusion prefusion NN cord-263469-2w26l80a 175 6 configurations configuration NNS cord-263469-2w26l80a 175 7 of of IN cord-263469-2w26l80a 175 8 class class NN cord-263469-2w26l80a 175 9 I i NN cord-263469-2w26l80a 175 10 , , , cord-263469-2w26l80a 175 11 II II NNP cord-263469-2w26l80a 175 12 and and CC cord-263469-2w26l80a 175 13 II II NNP cord-263469-2w26l80a 175 14 VFPs vfp NNS cord-263469-2w26l80a 175 15 are be VBP cord-263469-2w26l80a 175 16 highly highly RB cord-263469-2w26l80a 175 17 variable variable JJ cord-263469-2w26l80a 175 18 . . . cord-263469-2w26l80a 176 1 The the DT cord-263469-2w26l80a 176 2 virion virion NN cord-263469-2w26l80a 176 3 configuration configuration NN cord-263469-2w26l80a 176 4 of of IN cord-263469-2w26l80a 176 5 VSV VSV NNP cord-263469-2w26l80a 176 6 G G NNP cord-263469-2w26l80a 176 7 is be VBZ cord-263469-2w26l80a 176 8 homotrimer homotrimer NNP cord-263469-2w26l80a 176 9 arranged arrange VBN cord-263469-2w26l80a 176 10 in in IN cord-263469-2w26l80a 176 11 a a DT cord-263469-2w26l80a 176 12 tripod tripod NN cord-263469-2w26l80a 176 13 shape shape NN cord-263469-2w26l80a 176 14 with with IN cord-263469-2w26l80a 176 15 the the DT cord-263469-2w26l80a 176 16 fusion fusion NN cord-263469-2w26l80a 176 17 domains domain NNS cord-263469-2w26l80a 176 18 corresponding correspond VBG cord-263469-2w26l80a 176 19 to to IN cord-263469-2w26l80a 176 20 the the DT cord-263469-2w26l80a 176 21 legs leg NNS cord-263469-2w26l80a 176 22 of of IN cord-263469-2w26l80a 176 23 the the DT cord-263469-2w26l80a 176 24 tripod tripod NN cord-263469-2w26l80a 176 25 [ [ -LRB- cord-263469-2w26l80a 176 26 31 31 CD cord-263469-2w26l80a 176 27 ] ] -RRB- cord-263469-2w26l80a 176 28 . . . cord-263469-2w26l80a 177 1 No no DT cord-263469-2w26l80a 177 2 structural structural JJ cord-263469-2w26l80a 177 3 prediction prediction NN cord-263469-2w26l80a 177 4 of of IN cord-263469-2w26l80a 177 5 the the DT cord-263469-2w26l80a 177 6 prefusion prefusion NN cord-263469-2w26l80a 177 7 configurations configuration NNS cord-263469-2w26l80a 177 8 of of IN cord-263469-2w26l80a 177 9 BVD BVD NNP cord-263469-2w26l80a 177 10 GP GP NNP cord-263469-2w26l80a 177 11 is be VBZ cord-263469-2w26l80a 177 12 possible possible JJ cord-263469-2w26l80a 177 13 . . . cord-263469-2w26l80a 178 1 As as IN cord-263469-2w26l80a 178 2 in in IN cord-263469-2w26l80a 178 3 the the DT cord-263469-2w26l80a 178 4 case case NN cord-263469-2w26l80a 178 5 of of IN cord-263469-2w26l80a 178 6 class class NN cord-263469-2w26l80a 178 7 I -PRON- PRP cord-263469-2w26l80a 178 8 fusion fusion NN cord-263469-2w26l80a 178 9 proteins protein NNS cord-263469-2w26l80a 178 10 , , , cord-263469-2w26l80a 178 11 BDV BDV NNP cord-263469-2w26l80a 178 12 G G NNP cord-263469-2w26l80a 178 13 is be VBZ cord-263469-2w26l80a 178 14 cleaved cleave VBN cord-263469-2w26l80a 178 15 by by IN cord-263469-2w26l80a 178 16 a a DT cord-263469-2w26l80a 178 17 cellular cellular JJ cord-263469-2w26l80a 178 18 protease protease NN cord-263469-2w26l80a 178 19 into into IN cord-263469-2w26l80a 178 20 two two CD cord-263469-2w26l80a 178 21 subunits subunit NNS cord-263469-2w26l80a 178 22 [ [ -LRB- cord-263469-2w26l80a 178 23 11 11 CD cord-263469-2w26l80a 178 24 , , , cord-263469-2w26l80a 178 25 9 9 CD cord-263469-2w26l80a 178 26 ] ] -RRB- cord-263469-2w26l80a 178 27 . . . cord-263469-2w26l80a 179 1 It -PRON- PRP cord-263469-2w26l80a 179 2 has have VBZ cord-263469-2w26l80a 179 3 been be VBN cord-263469-2w26l80a 179 4 suggested suggest VBN cord-263469-2w26l80a 179 5 that that IN cord-263469-2w26l80a 179 6 hydrophobic hydrophobic JJ cord-263469-2w26l80a 179 7 sequences sequence NNS cord-263469-2w26l80a 179 8 following follow VBG cord-263469-2w26l80a 179 9 this this DT cord-263469-2w26l80a 179 10 cleavage cleavage NN cord-263469-2w26l80a 179 11 site site NN cord-263469-2w26l80a 179 12 near near IN cord-263469-2w26l80a 179 13 the the DT cord-263469-2w26l80a 179 14 GP2 GP2 NNP cord-263469-2w26l80a 179 15 N n CD cord-263469-2w26l80a 179 16 terminus terminus NN cord-263469-2w26l80a 179 17 may may MD cord-263469-2w26l80a 179 18 function function VB cord-263469-2w26l80a 179 19 as as IN cord-263469-2w26l80a 179 20 a a DT cord-263469-2w26l80a 179 21 fusion fusion NN cord-263469-2w26l80a 179 22 peptide peptide NN cord-263469-2w26l80a 179 23 [ [ -LRB- cord-263469-2w26l80a 179 24 11 11 CD cord-263469-2w26l80a 179 25 ] ] -RRB- cord-263469-2w26l80a 179 26 . . . cord-263469-2w26l80a 180 1 The the DT cord-263469-2w26l80a 180 2 current current JJ cord-263469-2w26l80a 180 3 modeling modeling NN cord-263469-2w26l80a 180 4 suggests suggest VBZ cord-263469-2w26l80a 180 5 that that IN cord-263469-2w26l80a 180 6 bornavirus bornavirus NNP cord-263469-2w26l80a 180 7 G G NNP cord-263469-2w26l80a 180 8 is be VBZ cord-263469-2w26l80a 180 9 not not RB cord-263469-2w26l80a 180 10 a a DT cord-263469-2w26l80a 180 11 class class NN cord-263469-2w26l80a 180 12 I -PRON- PRP cord-263469-2w26l80a 180 13 VFP VFP NNP cord-263469-2w26l80a 180 14 , , , cord-263469-2w26l80a 180 15 and and CC cord-263469-2w26l80a 180 16 does do VBZ cord-263469-2w26l80a 180 17 not not RB cord-263469-2w26l80a 180 18 corroborate corroborate VB cord-263469-2w26l80a 180 19 the the DT cord-263469-2w26l80a 180 20 existence existence NN cord-263469-2w26l80a 180 21 of of IN cord-263469-2w26l80a 180 22 a a DT cord-263469-2w26l80a 180 23 " " `` cord-263469-2w26l80a 180 24 fusion fusion NN cord-263469-2w26l80a 180 25 peptide peptide NN cord-263469-2w26l80a 180 26 " " '' cord-263469-2w26l80a 180 27 in in IN cord-263469-2w26l80a 180 28 GP2 GP2 NNP cord-263469-2w26l80a 180 29 . . . cord-263469-2w26l80a 181 1 The the DT cord-263469-2w26l80a 181 2 position position NN cord-263469-2w26l80a 181 3 of of IN cord-263469-2w26l80a 181 4 predicted predict VBN cord-263469-2w26l80a 181 5 α α NN cord-263469-2w26l80a 181 6 helices helix NNS cord-263469-2w26l80a 181 7 , , , cord-263469-2w26l80a 181 8 dicysteine dicysteine JJ cord-263469-2w26l80a 181 9 linkages linkage NNS cord-263469-2w26l80a 181 10 and and CC cord-263469-2w26l80a 181 11 membrane membrane NN cord-263469-2w26l80a 181 12 interactive interactive JJ cord-263469-2w26l80a 181 13 regions region NNS cord-263469-2w26l80a 181 14 ( ( -LRB- cord-263469-2w26l80a 181 15 sequences sequence NNS cord-263469-2w26l80a 181 16 with with IN cord-263469-2w26l80a 181 17 positive positive JJ cord-263469-2w26l80a 181 18 WWIHS WWIHS NNP cord-263469-2w26l80a 181 19 scores score NNS cord-263469-2w26l80a 181 20 ) ) -RRB- cord-263469-2w26l80a 181 21 are be VBP cord-263469-2w26l80a 181 22 not not RB cord-263469-2w26l80a 181 23 consistent consistent JJ cord-263469-2w26l80a 181 24 with with IN cord-263469-2w26l80a 181 25 assignment assignment NN cord-263469-2w26l80a 181 26 of of IN cord-263469-2w26l80a 181 27 BDV BDV NNP cord-263469-2w26l80a 181 28 G G NNP cord-263469-2w26l80a 181 29 to to IN cord-263469-2w26l80a 181 30 class class NN cord-263469-2w26l80a 181 31 I. i. NN cord-263469-2w26l80a 182 1 However however RB cord-263469-2w26l80a 182 2 , , , cord-263469-2w26l80a 182 3 the the DT cord-263469-2w26l80a 182 4 concept concept NN cord-263469-2w26l80a 182 5 that that IN cord-263469-2w26l80a 182 6 multiple multiple JJ cord-263469-2w26l80a 182 7 domains domain NNS cord-263469-2w26l80a 182 8 of of IN cord-263469-2w26l80a 182 9 bornavirus bornavirus NNP cord-263469-2w26l80a 182 10 G G NNP cord-263469-2w26l80a 182 11 participate participate VBP cord-263469-2w26l80a 182 12 in in IN cord-263469-2w26l80a 182 13 fusion fusion NN cord-263469-2w26l80a 182 14 of of IN cord-263469-2w26l80a 182 15 viral viral JJ cord-263469-2w26l80a 182 16 and and CC cord-263469-2w26l80a 182 17 cellular cellular JJ cord-263469-2w26l80a 182 18 membranes membrane NNS cord-263469-2w26l80a 182 19 is be VBZ cord-263469-2w26l80a 182 20 consistent consistent JJ cord-263469-2w26l80a 182 21 with with IN cord-263469-2w26l80a 182 22 current current JJ cord-263469-2w26l80a 182 23 viral viral JJ cord-263469-2w26l80a 182 24 entry entry NN cord-263469-2w26l80a 182 25 models model NNS cord-263469-2w26l80a 182 26 . . . cord-263469-2w26l80a 183 1 In in IN cord-263469-2w26l80a 183 2 class class NN cord-263469-2w26l80a 183 3 I -PRON- PRP cord-263469-2w26l80a 183 4 VFP VFP NNP cord-263469-2w26l80a 183 5 both both PDT cord-263469-2w26l80a 183 6 the the DT cord-263469-2w26l80a 183 7 amino amino NN cord-263469-2w26l80a 183 8 terminal terminal NN cord-263469-2w26l80a 183 9 fusion fusion NN cord-263469-2w26l80a 183 10 peptide peptide NN cord-263469-2w26l80a 183 11 , , , cord-263469-2w26l80a 183 12 the the DT cord-263469-2w26l80a 183 13 pre pre NN cord-263469-2w26l80a 183 14 - - NN cord-263469-2w26l80a 183 15 membrane membrane JJ cord-263469-2w26l80a 183 16 aromatic aromatic JJ cord-263469-2w26l80a 183 17 domain domain NN cord-263469-2w26l80a 183 18 and and CC cord-263469-2w26l80a 183 19 the the DT cord-263469-2w26l80a 183 20 TM TM NNP cord-263469-2w26l80a 183 21 cooperate cooperate VB cord-263469-2w26l80a 183 22 to to TO cord-263469-2w26l80a 183 23 mediate mediate VB cord-263469-2w26l80a 183 24 lipid lipid NN cord-263469-2w26l80a 183 25 mixing mixing NN cord-263469-2w26l80a 183 26 . . . cord-263469-2w26l80a 184 1 Likewise likewise RB cord-263469-2w26l80a 184 2 , , , cord-263469-2w26l80a 184 3 in in IN cord-263469-2w26l80a 184 4 class class NN cord-263469-2w26l80a 184 5 II II NNP cord-263469-2w26l80a 184 6 and and CC cord-263469-2w26l80a 184 7 III III NNP cord-263469-2w26l80a 184 8 VFP VFP NNP cord-263469-2w26l80a 184 9 , , , cord-263469-2w26l80a 184 10 fusion fusion NN cord-263469-2w26l80a 184 11 loops loop NNS cord-263469-2w26l80a 184 12 in in IN cord-263469-2w26l80a 184 13 domain domain NN cord-263469-2w26l80a 184 14 II II NNP cord-263469-2w26l80a 184 15 , , , cord-263469-2w26l80a 184 16 the the DT cord-263469-2w26l80a 184 17 stem stem NN cord-263469-2w26l80a 184 18 domain domain NN cord-263469-2w26l80a 184 19 , , , cord-263469-2w26l80a 184 20 TM TM NNP cord-263469-2w26l80a 184 21 and and CC cord-263469-2w26l80a 184 22 other other JJ cord-263469-2w26l80a 184 23 WWIHS WWIHS NNP cord-263469-2w26l80a 184 24 score score NN cord-263469-2w26l80a 184 25 positive positive JJ cord-263469-2w26l80a 184 26 sequences sequence NNS cord-263469-2w26l80a 184 27 all all DT cord-263469-2w26l80a 184 28 appear appear VBP cord-263469-2w26l80a 184 29 to to TO cord-263469-2w26l80a 184 30 participate participate VB cord-263469-2w26l80a 184 31 in in IN cord-263469-2w26l80a 184 32 fusion fusion NN cord-263469-2w26l80a 184 33 . . . cord-263469-2w26l80a 185 1 Several several JJ cord-263469-2w26l80a 185 2 of of IN cord-263469-2w26l80a 185 3 the the DT cord-263469-2w26l80a 185 4 domains domain NNS cord-263469-2w26l80a 185 5 of of IN cord-263469-2w26l80a 185 6 GP1 GP1 NNP cord-263469-2w26l80a 185 7 and and CC cord-263469-2w26l80a 185 8 GP2 GP2 NNP cord-263469-2w26l80a 185 9 , , , cord-263469-2w26l80a 185 10 particularly particularly RB cord-263469-2w26l80a 185 11 the the DT cord-263469-2w26l80a 185 12 putative putative JJ cord-263469-2w26l80a 185 13 fusion fusion NN cord-263469-2w26l80a 185 14 loops loop NNS cord-263469-2w26l80a 185 15 ( ( -LRB- cord-263469-2w26l80a 185 16 domain domain NN cord-263469-2w26l80a 185 17 II II NNP cord-263469-2w26l80a 185 18 ) ) -RRB- cord-263469-2w26l80a 185 19 , , , cord-263469-2w26l80a 185 20 the the DT cord-263469-2w26l80a 185 21 sequences sequence NNS cord-263469-2w26l80a 185 22 with with IN cord-263469-2w26l80a 185 23 positive positive JJ cord-263469-2w26l80a 185 24 WWIHS WWIHS NNP cord-263469-2w26l80a 185 25 scores score NNS cord-263469-2w26l80a 185 26 in in IN cord-263469-2w26l80a 185 27 GP2 GP2 NNP cord-263469-2w26l80a 185 28 , , , cord-263469-2w26l80a 185 29 and and CC cord-263469-2w26l80a 185 30 the the DT cord-263469-2w26l80a 185 31 stem stem NN cord-263469-2w26l80a 185 32 and and CC cord-263469-2w26l80a 185 33 TM TM NNP cord-263469-2w26l80a 185 34 domain domain NN cord-263469-2w26l80a 185 35 could could MD cord-263469-2w26l80a 185 36 cooperate cooperate VB cord-263469-2w26l80a 185 37 or or CC cord-263469-2w26l80a 185 38 interact interact VB cord-263469-2w26l80a 185 39 to to TO cord-263469-2w26l80a 185 40 mediate mediate VB cord-263469-2w26l80a 185 41 fusion fusion NN cord-263469-2w26l80a 185 42 and and CC cord-263469-2w26l80a 185 43 entry entry NN cord-263469-2w26l80a 185 44 of of IN cord-263469-2w26l80a 185 45 BDV BDV NNP cord-263469-2w26l80a 185 46 . . . cord-263469-2w26l80a 186 1 BDV BDV NNP cord-263469-2w26l80a 186 2 entry entry NN cord-263469-2w26l80a 186 3 is be VBZ cord-263469-2w26l80a 186 4 via via IN cord-263469-2w26l80a 186 5 clathrin clathrin NN cord-263469-2w26l80a 186 6 - - HYPH cord-263469-2w26l80a 186 7 mediated mediate VBN cord-263469-2w26l80a 186 8 endocytosis endocytosis NN cord-263469-2w26l80a 186 9 , , , cord-263469-2w26l80a 186 10 and and CC cord-263469-2w26l80a 186 11 the the DT cord-263469-2w26l80a 186 12 fusion fusion NN cord-263469-2w26l80a 186 13 between between IN cord-263469-2w26l80a 186 14 viral viral JJ cord-263469-2w26l80a 186 15 and and CC cord-263469-2w26l80a 186 16 cellular cellular JJ cord-263469-2w26l80a 186 17 membranes membrane NNS cord-263469-2w26l80a 186 18 occurs occur VBZ cord-263469-2w26l80a 186 19 in in IN cord-263469-2w26l80a 186 20 the the DT cord-263469-2w26l80a 186 21 mildly mildly RB cord-263469-2w26l80a 186 22 acidic acidic JJ cord-263469-2w26l80a 186 23 environment environment NN cord-263469-2w26l80a 186 24 of of IN cord-263469-2w26l80a 186 25 the the DT cord-263469-2w26l80a 186 26 early early JJ cord-263469-2w26l80a 186 27 endosome endosome NN cord-263469-2w26l80a 186 28 [ [ -LRB- cord-263469-2w26l80a 186 29 44 44 CD cord-263469-2w26l80a 186 30 ] ] -RRB- cord-263469-2w26l80a 186 31 . . . cord-263469-2w26l80a 187 1 The the DT cord-263469-2w26l80a 187 2 domains domain NNS cord-263469-2w26l80a 187 3 of of IN cord-263469-2w26l80a 187 4 BDV BDV NNP cord-263469-2w26l80a 187 5 G G NNP cord-263469-2w26l80a 187 6 involved involve VBN cord-263469-2w26l80a 187 7 in in IN cord-263469-2w26l80a 187 8 receptor receptor NN cord-263469-2w26l80a 187 9 recognition recognition NN cord-263469-2w26l80a 187 10 and and CC cord-263469-2w26l80a 187 11 cell cell NN cord-263469-2w26l80a 187 12 entry entry NN cord-263469-2w26l80a 187 13 have have VBP cord-263469-2w26l80a 187 14 not not RB cord-263469-2w26l80a 187 15 been be VBN cord-263469-2w26l80a 187 16 defined define VBN cord-263469-2w26l80a 187 17 . . . cord-263469-2w26l80a 188 1 GP1 gp1 NN cord-263469-2w26l80a 188 2 sequences sequence NNS cord-263469-2w26l80a 188 3 are be VBP cord-263469-2w26l80a 188 4 capable capable JJ cord-263469-2w26l80a 188 5 of of IN cord-263469-2w26l80a 188 6 mediating mediate VBG cord-263469-2w26l80a 188 7 attachment attachment NN cord-263469-2w26l80a 188 8 and and CC cord-263469-2w26l80a 188 9 entry entry NN cord-263469-2w26l80a 188 10 in in IN cord-263469-2w26l80a 188 11 VSV VSV NNP cord-263469-2w26l80a 188 12 pseudoparticles pseudoparticle NNS cord-263469-2w26l80a 188 13 in in IN cord-263469-2w26l80a 188 14 the the DT cord-263469-2w26l80a 188 15 absence absence NN cord-263469-2w26l80a 188 16 of of IN cord-263469-2w26l80a 188 17 GP2 GP2 NNP cord-263469-2w26l80a 188 18 [ [ -LRB- cord-263469-2w26l80a 188 19 15 15 CD cord-263469-2w26l80a 188 20 ] ] -RRB- cord-263469-2w26l80a 188 21 . . . cord-263469-2w26l80a 189 1 BDV BDV NNP cord-263469-2w26l80a 189 2 - - HYPH cord-263469-2w26l80a 189 3 infected infect VBN cord-263469-2w26l80a 189 4 cells cell NNS cord-263469-2w26l80a 189 5 exhibit exhibit VBP cord-263469-2w26l80a 189 6 syncytium syncytium NN cord-263469-2w26l80a 189 7 formation formation NN cord-263469-2w26l80a 189 8 upon upon IN cord-263469-2w26l80a 189 9 exposure exposure NN cord-263469-2w26l80a 189 10 to to IN cord-263469-2w26l80a 189 11 low low JJ cord-263469-2w26l80a 189 12 - - HYPH cord-263469-2w26l80a 189 13 pH ph NN cord-263469-2w26l80a 189 14 medium medium NN cord-263469-2w26l80a 189 15 [ [ -LRB- cord-263469-2w26l80a 189 16 10 10 CD cord-263469-2w26l80a 189 17 ] ] -RRB- cord-263469-2w26l80a 189 18 . . . cord-263469-2w26l80a 190 1 This this DT cord-263469-2w26l80a 190 2 pH ph JJ cord-263469-2w26l80a 190 3 - - HYPH cord-263469-2w26l80a 190 4 dependent dependent JJ cord-263469-2w26l80a 190 5 cell cell NN cord-263469-2w26l80a 190 6 fusion fusion NN cord-263469-2w26l80a 190 7 event event NN cord-263469-2w26l80a 190 8 is be VBZ cord-263469-2w26l80a 190 9 likely likely RB cord-263469-2w26l80a 190 10 mediated mediate VBN cord-263469-2w26l80a 190 11 by by IN cord-263469-2w26l80a 190 12 GP2 GP2 NNP cord-263469-2w26l80a 190 13 since since IN cord-263469-2w26l80a 190 14 it -PRON- PRP cord-263469-2w26l80a 190 15 is be VBZ cord-263469-2w26l80a 190 16 the the DT cord-263469-2w26l80a 190 17 only only RB cord-263469-2w26l80a 190 18 membraneanchored membraneanchore VBN cord-263469-2w26l80a 190 19 BDV BDV NNP cord-263469-2w26l80a 190 20 glycoprotein glycoprotein NN cord-263469-2w26l80a 190 21 found find VBN cord-263469-2w26l80a 190 22 on on IN cord-263469-2w26l80a 190 23 the the DT cord-263469-2w26l80a 190 24 plasma plasma NN cord-263469-2w26l80a 190 25 membrane membrane NN cord-263469-2w26l80a 190 26 . . . cord-263469-2w26l80a 191 1 These these DT cord-263469-2w26l80a 191 2 results result NNS cord-263469-2w26l80a 191 3 suggest suggest VBP cord-263469-2w26l80a 191 4 that that IN cord-263469-2w26l80a 191 5 both both CC cord-263469-2w26l80a 191 6 GP1 GP1 NNP cord-263469-2w26l80a 191 7 and and CC cord-263469-2w26l80a 191 8 GP2 GP2 NNP cord-263469-2w26l80a 191 9 are be VBP cord-263469-2w26l80a 191 10 involved involve VBN cord-263469-2w26l80a 191 11 in in IN cord-263469-2w26l80a 191 12 membrane membrane NN cord-263469-2w26l80a 191 13 fusion fusion NN cord-263469-2w26l80a 191 14 , , , cord-263469-2w26l80a 191 15 either either CC cord-263469-2w26l80a 191 16 cooperatively cooperatively RB cord-263469-2w26l80a 191 17 or or CC cord-263469-2w26l80a 191 18 in in IN cord-263469-2w26l80a 191 19 the the DT cord-263469-2w26l80a 191 20 case case NN cord-263469-2w26l80a 191 21 of of IN cord-263469-2w26l80a 191 22 cell cell NN cord-263469-2w26l80a 191 23 surface surface NN cord-263469-2w26l80a 191 24 expressed express VBD cord-263469-2w26l80a 191 25 GP2 GP2 NNP cord-263469-2w26l80a 191 26 independently independently RB cord-263469-2w26l80a 191 27 . . . cord-263469-2w26l80a 192 1 An an DT cord-263469-2w26l80a 192 2 analogous analogous JJ cord-263469-2w26l80a 192 3 situation situation NN cord-263469-2w26l80a 192 4 may may MD cord-263469-2w26l80a 192 5 exist exist VB cord-263469-2w26l80a 192 6 for for IN cord-263469-2w26l80a 192 7 hepatitis hepatitis NN cord-263469-2w26l80a 192 8 C C NNP cord-263469-2w26l80a 192 9 virus virus NN cord-263469-2w26l80a 192 10 ( ( -LRB- cord-263469-2w26l80a 192 11 HCV HCV NNP cord-263469-2w26l80a 192 12 ) ) -RRB- cord-263469-2w26l80a 192 13 . . . cord-263469-2w26l80a 193 1 Our -PRON- PRP$ cord-263469-2w26l80a 193 2 previous previous JJ cord-263469-2w26l80a 193 3 modeling modeling NN cord-263469-2w26l80a 193 4 suggested suggest VBD cord-263469-2w26l80a 193 5 that that IN cord-263469-2w26l80a 193 6 the the DT cord-263469-2w26l80a 193 7 envelope envelope NN cord-263469-2w26l80a 193 8 proteins protein NNS cord-263469-2w26l80a 193 9 of of IN cord-263469-2w26l80a 193 10 HCV HCV NNP cord-263469-2w26l80a 193 11 split split VBD cord-263469-2w26l80a 193 12 the the DT cord-263469-2w26l80a 193 13 duties duty NNS cord-263469-2w26l80a 193 14 performed perform VBN cord-263469-2w26l80a 193 15 by by IN cord-263469-2w26l80a 193 16 envelope envelope NN cord-263469-2w26l80a 193 17 proteins protein NNS cord-263469-2w26l80a 193 18 of of IN cord-263469-2w26l80a 193 19 other other JJ cord-263469-2w26l80a 193 20 members member NNS cord-263469-2w26l80a 193 21 of of IN cord-263469-2w26l80a 193 22 the the DT cord-263469-2w26l80a 193 23 Flaviviridae Flaviviridae NNP cord-263469-2w26l80a 193 24 , , , cord-263469-2w26l80a 193 25 E E NNP cord-263469-2w26l80a 193 26 of of IN cord-263469-2w26l80a 193 27 flaviviruses flavivirus NNS cord-263469-2w26l80a 193 28 and and CC cord-263469-2w26l80a 193 29 E2 E2 NNP cord-263469-2w26l80a 193 30 of of IN cord-263469-2w26l80a 193 31 pestiviruses pestiviruses NNP cord-263469-2w26l80a 193 32 [ [ -LRB- cord-263469-2w26l80a 193 33 27 27 CD cord-263469-2w26l80a 193 34 ] ] -RRB- cord-263469-2w26l80a 193 35 . . . cord-263469-2w26l80a 194 1 HCV HCV NNP cord-263469-2w26l80a 194 2 E1 E1 NNP cord-263469-2w26l80a 194 3 contains contain VBZ cord-263469-2w26l80a 194 4 the the DT cord-263469-2w26l80a 194 5 fusion fusion NN cord-263469-2w26l80a 194 6 loops loop NNS cord-263469-2w26l80a 194 7 that that WDT cord-263469-2w26l80a 194 8 are be VBP cord-263469-2w26l80a 194 9 analogous analogous JJ cord-263469-2w26l80a 194 10 to to IN cord-263469-2w26l80a 194 11 the the DT cord-263469-2w26l80a 194 12 domain domain NN cord-263469-2w26l80a 194 13 II ii CD cord-263469-2w26l80a 194 14 fusion fusion NN cord-263469-2w26l80a 194 15 loops loop NNS cord-263469-2w26l80a 194 16 of of IN cord-263469-2w26l80a 194 17 E e NN cord-263469-2w26l80a 194 18 / / SYM cord-263469-2w26l80a 194 19 E2 E2 NNP cord-263469-2w26l80a 194 20 , , , cord-263469-2w26l80a 194 21 while while IN cord-263469-2w26l80a 194 22 HCV HCV NNP cord-263469-2w26l80a 194 23 E2 E2 NNP cord-263469-2w26l80a 194 24 contains contain VBZ cord-263469-2w26l80a 194 25 receptor receptor NN cord-263469-2w26l80a 194 26 binding bind VBG cord-263469-2w26l80a 194 27 domains domain NNS cord-263469-2w26l80a 194 28 analogous analogous JJ cord-263469-2w26l80a 194 29 to to IN cord-263469-2w26l80a 194 30 domain domain NN cord-263469-2w26l80a 194 31 III iii CD cord-263469-2w26l80a 194 32 of of IN cord-263469-2w26l80a 194 33 E E NNP cord-263469-2w26l80a 194 34 / / SYM cord-263469-2w26l80a 194 35 E2 E2 NNP cord-263469-2w26l80a 194 36 , , , cord-263469-2w26l80a 194 37 as as RB cord-263469-2w26l80a 194 38 well well RB cord-263469-2w26l80a 194 39 as as IN cord-263469-2w26l80a 194 40 the the DT cord-263469-2w26l80a 194 41 stem stem NN cord-263469-2w26l80a 194 42 domain domain NN cord-263469-2w26l80a 194 43 . . . cord-263469-2w26l80a 195 1 The the DT cord-263469-2w26l80a 195 2 BDV BDV NNP cord-263469-2w26l80a 195 3 cellular cellular JJ cord-263469-2w26l80a 195 4 receptor(s receptor(s NNP cord-263469-2w26l80a 195 5 ) ) -RRB- cord-263469-2w26l80a 195 6 has have VBZ cord-263469-2w26l80a 195 7 not not RB cord-263469-2w26l80a 195 8 been be VBN cord-263469-2w26l80a 195 9 identified identify VBN cord-263469-2w26l80a 195 10 . . . cord-263469-2w26l80a 196 1 Baculoviruses Baculoviruses NNP cord-263469-2w26l80a 196 2 , , , cord-263469-2w26l80a 196 3 which which WDT cord-263469-2w26l80a 196 4 have have VBP cord-263469-2w26l80a 196 5 a a DT cord-263469-2w26l80a 196 6 broad broad JJ cord-263469-2w26l80a 196 7 host host NN cord-263469-2w26l80a 196 8 range range NN cord-263469-2w26l80a 196 9 , , , cord-263469-2w26l80a 196 10 may may MD cord-263469-2w26l80a 196 11 not not RB cord-263469-2w26l80a 196 12 possess possess VB cord-263469-2w26l80a 196 13 a a DT cord-263469-2w26l80a 196 14 specific specific JJ cord-263469-2w26l80a 196 15 protein protein NN cord-263469-2w26l80a 196 16 receptor receptor NN cord-263469-2w26l80a 196 17 . . . cord-263469-2w26l80a 197 1 Rather rather RB cord-263469-2w26l80a 197 2 , , , cord-263469-2w26l80a 197 3 it -PRON- PRP cord-263469-2w26l80a 197 4 has have VBZ cord-263469-2w26l80a 197 5 been be VBN cord-263469-2w26l80a 197 6 suggested suggest VBN cord-263469-2w26l80a 197 7 that that IN cord-263469-2w26l80a 197 8 the the DT cord-263469-2w26l80a 197 9 fusion fusion NN cord-263469-2w26l80a 197 10 loops loop NNS cord-263469-2w26l80a 197 11 ( ( -LRB- cord-263469-2w26l80a 197 12 domain domain NN cord-263469-2w26l80a 197 13 II II NNP cord-263469-2w26l80a 197 14 ) ) -RRB- cord-263469-2w26l80a 197 15 of of IN cord-263469-2w26l80a 197 16 baculovirus baculovirus NNP cord-263469-2w26l80a 197 17 gp64 gp64 RB cord-263469-2w26l80a 197 18 , , , cord-263469-2w26l80a 197 19 a a DT cord-263469-2w26l80a 197 20 class class NN cord-263469-2w26l80a 197 21 III III NNP cord-263469-2w26l80a 197 22 VFP VFP NNP cord-263469-2w26l80a 197 23 , , , cord-263469-2w26l80a 197 24 may may MD cord-263469-2w26l80a 197 25 be be VB cord-263469-2w26l80a 197 26 the the DT cord-263469-2w26l80a 197 27 initial initial JJ cord-263469-2w26l80a 197 28 binding binding NN cord-263469-2w26l80a 197 29 point point NN cord-263469-2w26l80a 197 30 with with IN cord-263469-2w26l80a 197 31 lipids lipid NNS cord-263469-2w26l80a 197 32 of of IN cord-263469-2w26l80a 197 33 the the DT cord-263469-2w26l80a 197 34 target target NN cord-263469-2w26l80a 197 35 cell cell NN cord-263469-2w26l80a 197 36 membrane membrane NN cord-263469-2w26l80a 197 37 [ [ -LRB- cord-263469-2w26l80a 197 38 34 34 CD cord-263469-2w26l80a 197 39 ] ] -RRB- cord-263469-2w26l80a 197 40 . . . cord-263469-2w26l80a 198 1 The the DT cord-263469-2w26l80a 198 2 host host NN cord-263469-2w26l80a 198 3 range range NN cord-263469-2w26l80a 198 4 of of IN cord-263469-2w26l80a 198 5 bornaviruses bornaviruse NNS cord-263469-2w26l80a 198 6 also also RB cord-263469-2w26l80a 198 7 appears appear VBZ cord-263469-2w26l80a 198 8 to to TO cord-263469-2w26l80a 198 9 be be VB cord-263469-2w26l80a 198 10 broad broad JJ cord-263469-2w26l80a 198 11 . . . cord-263469-2w26l80a 199 1 Whether whether IN cord-263469-2w26l80a 199 2 bornavirus bornavirus NNP cord-263469-2w26l80a 199 3 G G NNP cord-263469-2w26l80a 199 4 utilizes utilize VBZ cord-263469-2w26l80a 199 5 a a DT cord-263469-2w26l80a 199 6 specific specific JJ cord-263469-2w26l80a 199 7 protein protein NN cord-263469-2w26l80a 199 8 receptor receptor NN cord-263469-2w26l80a 199 9 or or CC cord-263469-2w26l80a 199 10 bind bind VB cord-263469-2w26l80a 199 11 to to IN cord-263469-2w26l80a 199 12 lipids lipid NNS cord-263469-2w26l80a 199 13 or or CC cord-263469-2w26l80a 199 14 other other JJ cord-263469-2w26l80a 199 15 ubiquitous ubiquitous JJ cord-263469-2w26l80a 199 16 components component NNS cord-263469-2w26l80a 199 17 of of IN cord-263469-2w26l80a 199 18 cellular cellular JJ cord-263469-2w26l80a 199 19 membranes membrane NNS cord-263469-2w26l80a 199 20 remains remain VBZ cord-263469-2w26l80a 199 21 to to TO cord-263469-2w26l80a 199 22 be be VB cord-263469-2w26l80a 199 23 determined determine VBN cord-263469-2w26l80a 199 24 . . . cord-263469-2w26l80a 200 1 Orthomyxoviridae Orthomyxoviridae NNP cord-263469-2w26l80a 200 2 , , , cord-263469-2w26l80a 200 3 Retroviridae Retroviridae NNP cord-263469-2w26l80a 200 4 , , , cord-263469-2w26l80a 200 5 Paramyxoviridae Paramyxoviridae NNP cord-263469-2w26l80a 200 6 , , , cord-263469-2w26l80a 200 7 Filoviridae Filoviridae NNP cord-263469-2w26l80a 200 8 , , , cord-263469-2w26l80a 200 9 Arenaviridae Arenaviridae NNP cord-263469-2w26l80a 200 10 , , , cord-263469-2w26l80a 200 11 and and CC cord-263469-2w26l80a 200 12 Coronaviridae Coronaviridae NNP cord-263469-2w26l80a 200 13 and and CC cord-263469-2w26l80a 200 14 Baculoviridae Baculoviridae NNP cord-263469-2w26l80a 200 15 have have VBP cord-263469-2w26l80a 200 16 members member NNS cord-263469-2w26l80a 200 17 that that WDT cord-263469-2w26l80a 200 18 encode encode VBP cord-263469-2w26l80a 200 19 class class NN cord-263469-2w26l80a 200 20 I -PRON- PRP cord-263469-2w26l80a 200 21 VFP VFP NNP cord-263469-2w26l80a 200 22 [ [ -LRB- cord-263469-2w26l80a 200 23 16 16 CD cord-263469-2w26l80a 200 24 , , , cord-263469-2w26l80a 200 25 22 22 CD cord-263469-2w26l80a 200 26 , , , cord-263469-2w26l80a 200 27 [ [ -LRB- cord-263469-2w26l80a 200 28 17 17 CD cord-263469-2w26l80a 200 29 ] ] -RRB- cord-263469-2w26l80a 200 30 [ [ -LRB- cord-263469-2w26l80a 200 31 18 18 CD cord-263469-2w26l80a 200 32 ] ] -RRB- cord-263469-2w26l80a 200 33 [ [ -LRB- cord-263469-2w26l80a 200 34 19 19 CD cord-263469-2w26l80a 200 35 ] ] -RRB- cord-263469-2w26l80a 200 36 [ [ -LRB- cord-263469-2w26l80a 200 37 20 20 CD cord-263469-2w26l80a 200 38 ] ] -RRB- cord-263469-2w26l80a 200 39 [ [ -LRB- cord-263469-2w26l80a 200 40 21 21 CD cord-263469-2w26l80a 200 41 ] ] -RRB- cord-263469-2w26l80a 200 42 45 45 CD cord-263469-2w26l80a 200 43 ] ] -RRB- cord-263469-2w26l80a 200 44 . . . cord-263469-2w26l80a 201 1 Flaviviridae Flaviviridae NNP cord-263469-2w26l80a 201 2 , , , cord-263469-2w26l80a 201 3 Togaviridae Togaviridae NNP cord-263469-2w26l80a 201 4 , , , cord-263469-2w26l80a 201 5 and and CC cord-263469-2w26l80a 201 6 Bunyaviridae Bunyaviridae NNP cord-263469-2w26l80a 201 7 family family NN cord-263469-2w26l80a 201 8 members member NNS cord-263469-2w26l80a 201 9 are be VBP cord-263469-2w26l80a 201 10 known know VBN cord-263469-2w26l80a 201 11 or or CC cord-263469-2w26l80a 201 12 appear appear VB cord-263469-2w26l80a 201 13 to to TO cord-263469-2w26l80a 201 14 have have VB cord-263469-2w26l80a 201 15 members member NNS cord-263469-2w26l80a 201 16 that that WDT cord-263469-2w26l80a 201 17 encode encode VBP cord-263469-2w26l80a 201 18 class class NN cord-263469-2w26l80a 201 19 II II NNP cord-263469-2w26l80a 201 20 VFP VFP NNP cord-263469-2w26l80a 201 21 [ [ -LRB- cord-263469-2w26l80a 201 22 24 24 CD cord-263469-2w26l80a 201 23 , , , cord-263469-2w26l80a 201 24 [ [ -LRB- cord-263469-2w26l80a 201 25 27 27 CD cord-263469-2w26l80a 201 26 ] ] -RRB- cord-263469-2w26l80a 202 1 [ [ -LRB- cord-263469-2w26l80a 202 2 28 28 CD cord-263469-2w26l80a 202 3 ] ] -RRB- cord-263469-2w26l80a 202 4 [ [ -LRB- cord-263469-2w26l80a 202 5 29 29 CD cord-263469-2w26l80a 202 6 ] ] -RRB- cord-263469-2w26l80a 202 7 . . . cord-263469-2w26l80a 203 1 If if IN cord-263469-2w26l80a 203 2 the the DT cord-263469-2w26l80a 203 3 current current JJ cord-263469-2w26l80a 203 4 analyses analysis NNS cord-263469-2w26l80a 203 5 are be VBP cord-263469-2w26l80a 203 6 correct correct JJ cord-263469-2w26l80a 203 7 , , , cord-263469-2w26l80a 203 8 BDV BDV NNP cord-263469-2w26l80a 203 9 G G NNP cord-263469-2w26l80a 203 10 joins join VBZ cord-263469-2w26l80a 203 11 rhabdovirus rhabdovirus NNP cord-263469-2w26l80a 203 12 G G NNP cord-263469-2w26l80a 203 13 , , , cord-263469-2w26l80a 203 14 herpeviruses herpeviruses NNP cord-263469-2w26l80a 203 15 gB gB NNP cord-263469-2w26l80a 203 16 , , , cord-263469-2w26l80a 203 17 thogotovirus thogotovirus NNP cord-263469-2w26l80a 203 18 G G NNP cord-263469-2w26l80a 203 19 and and CC cord-263469-2w26l80a 203 20 baculovirus baculovirus NN cord-263469-2w26l80a 203 21 GP64 GP64 NNP cord-263469-2w26l80a 203 22 and and CC cord-263469-2w26l80a 203 23 as as IN cord-263469-2w26l80a 203 24 a a DT cord-263469-2w26l80a 203 25 class class NN cord-263469-2w26l80a 203 26 III iii NN cord-263469-2w26l80a 203 27 VFP vfp NN cord-263469-2w26l80a 203 28 . . . cord-263469-2w26l80a 204 1 While while IN cord-263469-2w26l80a 204 2 convergence convergence NN cord-263469-2w26l80a 204 3 to to IN cord-263469-2w26l80a 204 4 common common JJ cord-263469-2w26l80a 204 5 structures structure NNS cord-263469-2w26l80a 204 6 is be VBZ cord-263469-2w26l80a 204 7 possible possible JJ cord-263469-2w26l80a 204 8 , , , cord-263469-2w26l80a 204 9 VFP VFP NNP cord-263469-2w26l80a 204 10 of of IN cord-263469-2w26l80a 204 11 enveloped envelop VBN cord-263469-2w26l80a 204 12 viruses virus NNS cord-263469-2w26l80a 204 13 may may MD cord-263469-2w26l80a 204 14 have have VB cord-263469-2w26l80a 204 15 evolved evolve VBN cord-263469-2w26l80a 204 16 from from IN cord-263469-2w26l80a 204 17 a a DT cord-263469-2w26l80a 204 18 limited limited JJ cord-263469-2w26l80a 204 19 number number NN cord-263469-2w26l80a 204 20 of of IN cord-263469-2w26l80a 204 21 common common JJ cord-263469-2w26l80a 204 22 progenitors progenitor NNS cord-263469-2w26l80a 204 23 . . . cord-263469-2w26l80a 205 1 Support support NN cord-263469-2w26l80a 205 2 for for IN cord-263469-2w26l80a 205 3 this this DT cord-263469-2w26l80a 205 4 hypothesis hypothesis NN cord-263469-2w26l80a 205 5 comes come VBZ cord-263469-2w26l80a 205 6 from from IN cord-263469-2w26l80a 205 7 the the DT cord-263469-2w26l80a 205 8 remarkable remarkable JJ cord-263469-2w26l80a 205 9 similarities similarity NNS cord-263469-2w26l80a 205 10 in in IN cord-263469-2w26l80a 205 11 the the DT cord-263469-2w26l80a 205 12 post post JJ cord-263469-2w26l80a 205 13 - - JJ cord-263469-2w26l80a 205 14 fusion fusion JJ cord-263469-2w26l80a 205 15 structures structure NNS cord-263469-2w26l80a 205 16 of of IN cord-263469-2w26l80a 205 17 the the DT cord-263469-2w26l80a 205 18 VFP VFP NNP cord-263469-2w26l80a 205 19 in in IN cord-263469-2w26l80a 205 20 each each DT cord-263469-2w26l80a 205 21 class class NN cord-263469-2w26l80a 205 22 , , , cord-263469-2w26l80a 205 23 even even RB cord-263469-2w26l80a 205 24 though though IN cord-263469-2w26l80a 205 25 the the DT cord-263469-2w26l80a 205 26 proteins protein NNS cord-263469-2w26l80a 205 27 differ differ VBP cord-263469-2w26l80a 205 28 dramatically dramatically RB cord-263469-2w26l80a 205 29 in in IN cord-263469-2w26l80a 205 30 aa aa NNP cord-263469-2w26l80a 205 31 sequence sequence NN cord-263469-2w26l80a 205 32 . . . cord-263469-2w26l80a 206 1 While while IN cord-263469-2w26l80a 206 2 , , , cord-263469-2w26l80a 206 3 it -PRON- PRP cord-263469-2w26l80a 206 4 is be VBZ cord-263469-2w26l80a 206 5 probable probable JJ cord-263469-2w26l80a 206 6 that that IN cord-263469-2w26l80a 206 7 other other JJ cord-263469-2w26l80a 206 8 classes class NNS cord-263469-2w26l80a 206 9 of of IN cord-263469-2w26l80a 206 10 VFP VFP NNP cord-263469-2w26l80a 206 11 exist exist VBP cord-263469-2w26l80a 206 12 , , , cord-263469-2w26l80a 206 13 there there EX cord-263469-2w26l80a 206 14 appears appear VBZ cord-263469-2w26l80a 206 15 be be VB cord-263469-2w26l80a 206 16 a a DT cord-263469-2w26l80a 206 17 limited limited JJ cord-263469-2w26l80a 206 18 number number NN cord-263469-2w26l80a 206 19 of of IN cord-263469-2w26l80a 206 20 effective effective JJ cord-263469-2w26l80a 206 21 structures structure NNS cord-263469-2w26l80a 206 22 for for IN cord-263469-2w26l80a 206 23 virus virus NN cord-263469-2w26l80a 206 24 - - HYPH cord-263469-2w26l80a 206 25 mediated mediate VBN cord-263469-2w26l80a 206 26 membrane membrane NN cord-263469-2w26l80a 206 27 fusion fusion NN cord-263469-2w26l80a 206 28 . . . cord-263469-2w26l80a 207 1 The the DT cord-263469-2w26l80a 207 2 Bornaviridae Bornaviridae NNP cord-263469-2w26l80a 207 3 are be VBP cord-263469-2w26l80a 207 4 included include VBN cord-263469-2w26l80a 207 5 with with IN cord-263469-2w26l80a 207 6 the the DT cord-263469-2w26l80a 207 7 Rhabdovirdae Rhabdovirdae NNP cord-263469-2w26l80a 207 8 and and CC cord-263469-2w26l80a 207 9 Paramyxoviridae Paramyxoviridae NNP cord-263469-2w26l80a 207 10 in in IN cord-263469-2w26l80a 207 11 the the DT cord-263469-2w26l80a 207 12 order order NN cord-263469-2w26l80a 207 13 Mononegavirales Mononegavirales NNP cord-263469-2w26l80a 207 14 . . . cord-263469-2w26l80a 208 1 Paramyxoviruses paramyxovirus NNS cord-263469-2w26l80a 208 2 possess possess VBP cord-263469-2w26l80a 208 3 a a DT cord-263469-2w26l80a 208 4 class class NN cord-263469-2w26l80a 208 5 I -PRON- PRP cord-263469-2w26l80a 208 6 VFP VFP NNP cord-263469-2w26l80a 208 7 , , , cord-263469-2w26l80a 208 8 whereas whereas IN cord-263469-2w26l80a 208 9 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 208 10 and and CC cord-263469-2w26l80a 208 11 , , , cord-263469-2w26l80a 208 12 as as IN cord-263469-2w26l80a 208 13 suggested suggest VBN cord-263469-2w26l80a 208 14 here here RB cord-263469-2w26l80a 208 15 , , , cord-263469-2w26l80a 208 16 bornaviruses bornaviruse NNS cord-263469-2w26l80a 208 17 encode encode VBP cord-263469-2w26l80a 208 18 class class NN cord-263469-2w26l80a 208 19 III III NNP cord-263469-2w26l80a 208 20 VFP vfp NN cord-263469-2w26l80a 208 21 . . . cord-263469-2w26l80a 209 1 There there EX cord-263469-2w26l80a 209 2 are be VBP cord-263469-2w26l80a 209 3 several several JJ cord-263469-2w26l80a 209 4 possibilities possibility NNS cord-263469-2w26l80a 209 5 for for IN cord-263469-2w26l80a 209 6 how how WRB cord-263469-2w26l80a 209 7 the the DT cord-263469-2w26l80a 209 8 glycoproteins glycoprotein NNS cord-263469-2w26l80a 209 9 of of IN cord-263469-2w26l80a 209 10 members member NNS cord-263469-2w26l80a 209 11 of of IN cord-263469-2w26l80a 209 12 this this DT cord-263469-2w26l80a 209 13 order order NN cord-263469-2w26l80a 209 14 evolved evolve VBD cord-263469-2w26l80a 209 15 . . . cord-263469-2w26l80a 210 1 A a DT cord-263469-2w26l80a 210 2 G g NN cord-263469-2w26l80a 210 3 gene gene NN cord-263469-2w26l80a 210 4 appears appear VBZ cord-263469-2w26l80a 210 5 to to TO cord-263469-2w26l80a 210 6 have have VB cord-263469-2w26l80a 210 7 been be VBN cord-263469-2w26l80a 210 8 present present JJ cord-263469-2w26l80a 210 9 in in IN cord-263469-2w26l80a 210 10 the the DT cord-263469-2w26l80a 210 11 common common JJ cord-263469-2w26l80a 210 12 ancestors ancestor NNS cord-263469-2w26l80a 210 13 of of IN cord-263469-2w26l80a 210 14 all all DT cord-263469-2w26l80a 210 15 members member NNS cord-263469-2w26l80a 210 16 of of IN cord-263469-2w26l80a 210 17 the the DT cord-263469-2w26l80a 210 18 Rhabdoviridae Rhabdoviridae NNP cord-263469-2w26l80a 210 19 and and CC cord-263469-2w26l80a 210 20 Bornaviridae Bornaviridae NNP cord-263469-2w26l80a 210 21 . . . cord-263469-2w26l80a 211 1 The the DT cord-263469-2w26l80a 211 2 similarities similarity NNS cord-263469-2w26l80a 211 3 detected detect VBN cord-263469-2w26l80a 211 4 between between IN cord-263469-2w26l80a 211 5 rhabdovirus rhabdovirus NNP cord-263469-2w26l80a 211 6 and and CC cord-263469-2w26l80a 211 7 bornavirus bornavirus NNP cord-263469-2w26l80a 211 8 G G NNP cord-263469-2w26l80a 211 9 are be VBP cord-263469-2w26l80a 211 10 consistent consistent JJ cord-263469-2w26l80a 211 11 with with IN cord-263469-2w26l80a 211 12 divergent divergent JJ cord-263469-2w26l80a 211 13 evolution evolution NN cord-263469-2w26l80a 211 14 from from IN cord-263469-2w26l80a 211 15 a a DT cord-263469-2w26l80a 211 16 common common JJ cord-263469-2w26l80a 211 17 progenitor progenitor NN cord-263469-2w26l80a 211 18 , , , cord-263469-2w26l80a 211 19 but but CC cord-263469-2w26l80a 211 20 sequence sequence NN cord-263469-2w26l80a 211 21 similarities similarity NNS cord-263469-2w26l80a 211 22 are be VBP cord-263469-2w26l80a 211 23 insufficient insufficient JJ cord-263469-2w26l80a 211 24 to to TO cord-263469-2w26l80a 211 25 establish establish VB cord-263469-2w26l80a 211 26 a a DT cord-263469-2w26l80a 211 27 phylogenic phylogenic NN cord-263469-2w26l80a 211 28 relationship relationship NN cord-263469-2w26l80a 211 29 . . . cord-263469-2w26l80a 212 1 Therefore therefore RB cord-263469-2w26l80a 212 2 , , , cord-263469-2w26l80a 212 3 it -PRON- PRP cord-263469-2w26l80a 212 4 is be VBZ cord-263469-2w26l80a 212 5 possible possible JJ cord-263469-2w26l80a 212 6 that that IN cord-263469-2w26l80a 212 7 the the DT cord-263469-2w26l80a 212 8 class class NN cord-263469-2w26l80a 212 9 III III NNP cord-263469-2w26l80a 212 10 VFP VFP NNP cord-263469-2w26l80a 212 11 of of IN cord-263469-2w26l80a 212 12 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 212 13 and and CC cord-263469-2w26l80a 212 14 bornaviruses bornaviruse NNS cord-263469-2w26l80a 212 15 were be VBD cord-263469-2w26l80a 212 16 acquired acquire VBN cord-263469-2w26l80a 212 17 by by IN cord-263469-2w26l80a 212 18 independent independent JJ cord-263469-2w26l80a 212 19 genetic genetic JJ cord-263469-2w26l80a 212 20 events event NNS cord-263469-2w26l80a 212 21 . . . cord-263469-2w26l80a 213 1 An an DT cord-263469-2w26l80a 213 2 alternative alternative NN cord-263469-2w26l80a 213 3 suggested suggest VBN cord-263469-2w26l80a 213 4 by by IN cord-263469-2w26l80a 213 5 Kadlec Kadlec NNP cord-263469-2w26l80a 213 6 et et NNP cord-263469-2w26l80a 213 7 al al NNP cord-263469-2w26l80a 213 8 . . . cord-263469-2w26l80a 214 1 [ [ -LRB- cord-263469-2w26l80a 214 2 34 34 CD cord-263469-2w26l80a 214 3 ] ] -RRB- cord-263469-2w26l80a 214 4 is be VBZ cord-263469-2w26l80a 214 5 that that IN cord-263469-2w26l80a 214 6 the the DT cord-263469-2w26l80a 214 7 three three CD cord-263469-2w26l80a 214 8 classes class NNS cord-263469-2w26l80a 214 9 of of IN cord-263469-2w26l80a 214 10 VFP VFP NNP cord-263469-2w26l80a 214 11 may may MD cord-263469-2w26l80a 214 12 have have VB cord-263469-2w26l80a 214 13 evolved evolve VBN cord-263469-2w26l80a 214 14 from from IN cord-263469-2w26l80a 214 15 a a DT cord-263469-2w26l80a 214 16 common common JJ cord-263469-2w26l80a 214 17 precursor precursor NN cord-263469-2w26l80a 214 18 ( ( -LRB- cord-263469-2w26l80a 214 19 preclass preclass NNP cord-263469-2w26l80a 214 20 I I NNP cord-263469-2w26l80a 214 21 , , , cord-263469-2w26l80a 214 22 II II NNP cord-263469-2w26l80a 214 23 , , , cord-263469-2w26l80a 214 24 III III NNP cord-263469-2w26l80a 214 25 ) ) -RRB- cord-263469-2w26l80a 214 26 . . . cord-263469-2w26l80a 215 1 This this DT cord-263469-2w26l80a 215 2 concept concept NN cord-263469-2w26l80a 215 3 is be VBZ cord-263469-2w26l80a 215 4 based base VBN cord-263469-2w26l80a 215 5 on on IN cord-263469-2w26l80a 215 6 morph morph NN cord-263469-2w26l80a 215 7 videos video NNS cord-263469-2w26l80a 215 8 and and CC cord-263469-2w26l80a 215 9 other other JJ cord-263469-2w26l80a 215 10 analyses analysis NNS cord-263469-2w26l80a 215 11 that that WDT cord-263469-2w26l80a 215 12 reveal reveal VBP cord-263469-2w26l80a 215 13 domain domain NN cord-263469-2w26l80a 215 14 - - HYPH cord-263469-2w26l80a 215 15 specific specific JJ cord-263469-2w26l80a 215 16 folding folding NN cord-263469-2w26l80a 215 17 and and CC cord-263469-2w26l80a 215 18 structural structural JJ cord-263469-2w26l80a 215 19 similarities similarity NNS cord-263469-2w26l80a 215 20 amongst amongst IN cord-263469-2w26l80a 215 21 each each DT cord-263469-2w26l80a 215 22 of of IN cord-263469-2w26l80a 215 23 the the DT cord-263469-2w26l80a 215 24 three three CD cord-263469-2w26l80a 215 25 classes class NNS cord-263469-2w26l80a 215 26 of of IN cord-263469-2w26l80a 215 27 VFP VFP NNP cord-263469-2w26l80a 215 28 . . . cord-263469-2w26l80a 216 1 If if IN cord-263469-2w26l80a 216 2 this this DT cord-263469-2w26l80a 216 3 is be VBZ cord-263469-2w26l80a 216 4 the the DT cord-263469-2w26l80a 216 5 case case NN cord-263469-2w26l80a 216 6 , , , cord-263469-2w26l80a 216 7 mononegavirales mononegavirale NNS cord-263469-2w26l80a 216 8 evolution evolution NN cord-263469-2w26l80a 216 9 can can MD cord-263469-2w26l80a 216 10 be be VB cord-263469-2w26l80a 216 11 depicted depict VBN cord-263469-2w26l80a 216 12 as as IN cord-263469-2w26l80a 216 13 a a DT cord-263469-2w26l80a 216 14 " " `` cord-263469-2w26l80a 216 15 rooted root VBN cord-263469-2w26l80a 216 16 " " '' cord-263469-2w26l80a 216 17 tree tree NN cord-263469-2w26l80a 216 18 with with IN cord-263469-2w26l80a 216 19 the the DT cord-263469-2w26l80a 216 20 ancestral ancestral JJ cord-263469-2w26l80a 216 21 mononegavirus mononegavirus NN cord-263469-2w26l80a 216 22 possessing possess VBG cord-263469-2w26l80a 216 23 a a DT cord-263469-2w26l80a 216 24 progenitor progenitor NN cord-263469-2w26l80a 216 25 of of IN cord-263469-2w26l80a 216 26 class class NN cord-263469-2w26l80a 216 27 I i NN cord-263469-2w26l80a 216 28 , , , cord-263469-2w26l80a 216 29 III III NNP cord-263469-2w26l80a 216 30 and and CC cord-263469-2w26l80a 216 31 likely likely JJ cord-263469-2w26l80a 216 32 II II NNP cord-263469-2w26l80a 216 33 VFP VFP NNP cord-263469-2w26l80a 216 34 ( ( -LRB- cord-263469-2w26l80a 216 35 Fig Fig NNP cord-263469-2w26l80a 216 36 . . . cord-263469-2w26l80a 216 37 4A 4a CD cord-263469-2w26l80a 216 38 ) ) -RRB- cord-263469-2w26l80a 216 39 . . . cord-263469-2w26l80a 217 1 Alternatively alternatively RB cord-263469-2w26l80a 217 2 , , , cord-263469-2w26l80a 217 3 the the DT cord-263469-2w26l80a 217 4 VFP VFP NNP cord-263469-2w26l80a 217 5 of of IN cord-263469-2w26l80a 217 6 paramyxoviruses paramyxovirus NNS cord-263469-2w26l80a 217 7 could could MD cord-263469-2w26l80a 217 8 have have VB cord-263469-2w26l80a 217 9 been be VBN cord-263469-2w26l80a 217 10 acquired acquire VBN cord-263469-2w26l80a 217 11 independently independently RB cord-263469-2w26l80a 217 12 from from IN cord-263469-2w26l80a 217 13 the the DT cord-263469-2w26l80a 217 14 acquisition acquisition NN cord-263469-2w26l80a 217 15 of of IN cord-263469-2w26l80a 217 16 glycoproteins glycoprotein NNS cord-263469-2w26l80a 217 17 by by IN cord-263469-2w26l80a 217 18 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 217 19 and and CC cord-263469-2w26l80a 217 20 bornaviruses bornaviruse NNS cord-263469-2w26l80a 217 21 by by IN cord-263469-2w26l80a 217 22 horizontal horizontal JJ cord-263469-2w26l80a 217 23 gene gene NN cord-263469-2w26l80a 217 24 transfer transfer NN cord-263469-2w26l80a 217 25 . . . cord-263469-2w26l80a 218 1 This this DT cord-263469-2w26l80a 218 2 case case NN cord-263469-2w26l80a 218 3 can can MD cord-263469-2w26l80a 218 4 be be VB cord-263469-2w26l80a 218 5 depicted depict VBN cord-263469-2w26l80a 218 6 as as IN cord-263469-2w26l80a 218 7 an an DT cord-263469-2w26l80a 218 8 unrooted unrooted JJ cord-263469-2w26l80a 218 9 tree tree NN cord-263469-2w26l80a 218 10 , , , cord-263469-2w26l80a 218 11 in in IN cord-263469-2w26l80a 218 12 which which WDT cord-263469-2w26l80a 218 13 glycoproteins glycoprotein NNS cord-263469-2w26l80a 218 14 were be VBD cord-263469-2w26l80a 218 15 acquired acquire VBN cord-263469-2w26l80a 218 16 after after IN cord-263469-2w26l80a 218 17 divergent divergent JJ cord-263469-2w26l80a 218 18 of of IN cord-263469-2w26l80a 218 19 paramyxoviruses paramyxovirus NNS cord-263469-2w26l80a 218 20 from from IN cord-263469-2w26l80a 218 21 rhabdovirus rhabdovirus NNP cord-263469-2w26l80a 218 22 and and CC cord-263469-2w26l80a 218 23 bornaviruses bornaviruses NNP cord-263469-2w26l80a 218 24 ( ( -LRB- cord-263469-2w26l80a 218 25 Fig Fig NNP cord-263469-2w26l80a 218 26 . . . cord-263469-2w26l80a 218 27 4B 4b CD cord-263469-2w26l80a 218 28 ) ) -RRB- cord-263469-2w26l80a 218 29 . . . cord-263469-2w26l80a 219 1 VFP VFP NNP cord-263469-2w26l80a 219 2 are be VBP cord-263469-2w26l80a 219 3 highly highly RB cord-263469-2w26l80a 219 4 divergent divergent JJ cord-263469-2w26l80a 219 5 at at IN cord-263469-2w26l80a 219 6 the the DT cord-263469-2w26l80a 219 7 primary primary JJ cord-263469-2w26l80a 219 8 sequence sequence NN cord-263469-2w26l80a 219 9 level level NN cord-263469-2w26l80a 219 10 . . . cord-263469-2w26l80a 220 1 Therefore therefore RB cord-263469-2w26l80a 220 2 , , , cord-263469-2w26l80a 220 3 definitive definitive JJ cord-263469-2w26l80a 220 4 statistical statistical JJ cord-263469-2w26l80a 220 5 analyses analysis NNS cord-263469-2w26l80a 220 6 of of IN cord-263469-2w26l80a 220 7 these these DT cord-263469-2w26l80a 220 8 possibilities possibility NNS cord-263469-2w26l80a 220 9 are be VBP cord-263469-2w26l80a 220 10 not not RB cord-263469-2w26l80a 220 11 possible possible JJ cord-263469-2w26l80a 220 12 at at IN cord-263469-2w26l80a 220 13 this this DT cord-263469-2w26l80a 220 14 time time NN cord-263469-2w26l80a 220 15 . . . cord-263469-2w26l80a 221 1 The the DT cord-263469-2w26l80a 221 2 evolutionary evolutionary JJ cord-263469-2w26l80a 221 3 origins origin NNS cord-263469-2w26l80a 221 4 of of IN cord-263469-2w26l80a 221 5 VFP VFP NNP cord-263469-2w26l80a 221 6 , , , cord-263469-2w26l80a 221 7 which which WDT cord-263469-2w26l80a 221 8 display display VBP cord-263469-2w26l80a 221 9 many many JJ cord-263469-2w26l80a 221 10 common common JJ cord-263469-2w26l80a 221 11 structural structural JJ cord-263469-2w26l80a 221 12 features feature NNS cord-263469-2w26l80a 221 13 , , , cord-263469-2w26l80a 221 14 offer offer VBP cord-263469-2w26l80a 221 15 worthy worthy JJ cord-263469-2w26l80a 221 16 challenges challenge NNS cord-263469-2w26l80a 221 17 to to IN cord-263469-2w26l80a 221 18 computational computational JJ cord-263469-2w26l80a 221 19 biologists biologist NNS cord-263469-2w26l80a 221 20 . . . cord-263469-2w26l80a 222 1 In in IN cord-263469-2w26l80a 222 2 the the DT cord-263469-2w26l80a 222 3 absence absence NN cord-263469-2w26l80a 222 4 of of IN cord-263469-2w26l80a 222 5 determinations determination NNS cord-263469-2w26l80a 222 6 by by IN cord-263469-2w26l80a 222 7 X x NN cord-263469-2w26l80a 222 8 - - NN cord-263469-2w26l80a 222 9 ray ray NN cord-263469-2w26l80a 222 10 crystallography crystallography NN cord-263469-2w26l80a 222 11 , , , cord-263469-2w26l80a 222 12 structural structural JJ cord-263469-2w26l80a 222 13 models model NNS cord-263469-2w26l80a 222 14 such such JJ cord-263469-2w26l80a 222 15 as as IN cord-263469-2w26l80a 222 16 the the DT cord-263469-2w26l80a 222 17 one one NN cord-263469-2w26l80a 222 18 proposed propose VBN cord-263469-2w26l80a 222 19 here here RB cord-263469-2w26l80a 222 20 can can MD cord-263469-2w26l80a 222 21 provide provide VB cord-263469-2w26l80a 222 22 useful useful JJ cord-263469-2w26l80a 222 23 hypotheses hypothesis NNS cord-263469-2w26l80a 222 24 to to TO cord-263469-2w26l80a 222 25 guide guide VB cord-263469-2w26l80a 222 26 experimental experimental JJ cord-263469-2w26l80a 222 27 strategies strategy NNS cord-263469-2w26l80a 222 28 for for IN cord-263469-2w26l80a 222 29 development development NN cord-263469-2w26l80a 222 30 of of IN cord-263469-2w26l80a 222 31 vaccines vaccine NNS cord-263469-2w26l80a 222 32 or or CC cord-263469-2w26l80a 222 33 drugs drug NNS cord-263469-2w26l80a 222 34 to to TO cord-263469-2w26l80a 222 35 prevent prevent VB cord-263469-2w26l80a 222 36 or or CC cord-263469-2w26l80a 222 37 treat treat VB cord-263469-2w26l80a 222 38 infection infection NN cord-263469-2w26l80a 222 39 by by IN cord-263469-2w26l80a 222 40 bornavirus bornavirus NNP cord-263469-2w26l80a 222 41 infections infection NNS cord-263469-2w26l80a 222 42 . . . cord-263469-2w26l80a 223 1 Prior prior RB cord-263469-2w26l80a 223 2 to to IN cord-263469-2w26l80a 223 3 the the DT cord-263469-2w26l80a 223 4 availability availability NN cord-263469-2w26l80a 223 5 of of IN cord-263469-2w26l80a 223 6 X x NN cord-263469-2w26l80a 223 7 - - NN cord-263469-2w26l80a 223 8 ray ray JJ cord-263469-2w26l80a 223 9 structural structural JJ cord-263469-2w26l80a 223 10 data datum NNS cord-263469-2w26l80a 223 11 , , , cord-263469-2w26l80a 223 12 several several JJ cord-263469-2w26l80a 223 13 potent potent JJ cord-263469-2w26l80a 223 14 HIV-1 HIV-1 NNP cord-263469-2w26l80a 223 15 entry entry NN cord-263469-2w26l80a 223 16 inhibitors inhibitor NNS cord-263469-2w26l80a 223 17 were be VBD cord-263469-2w26l80a 223 18 developed develop VBN cord-263469-2w26l80a 223 19 [ [ -LRB- cord-263469-2w26l80a 223 20 46 46 CD cord-263469-2w26l80a 223 21 , , , cord-263469-2w26l80a 223 22 47 47 CD cord-263469-2w26l80a 223 23 ] ] -RRB- cord-263469-2w26l80a 223 24 based base VBN cord-263469-2w26l80a 223 25 on on IN cord-263469-2w26l80a 223 26 the the DT cord-263469-2w26l80a 223 27 Gallaher Gallaher NNP cord-263469-2w26l80a 223 28 HIV-1 HIV-1 NNP cord-263469-2w26l80a 223 29 TM TM NNP cord-263469-2w26l80a 223 30 fusion fusion NN cord-263469-2w26l80a 223 31 protein protein NN cord-263469-2w26l80a 223 32 model model NN cord-263469-2w26l80a 223 33 [ [ -LRB- cord-263469-2w26l80a 223 34 17 17 CD cord-263469-2w26l80a 223 35 ] ] -RRB- cord-263469-2w26l80a 223 36 . . . cord-263469-2w26l80a 224 1 Fuzeon Fuzeon NNP cord-263469-2w26l80a 224 2 ™ ™ NN cord-263469-2w26l80a 224 3 ( ( -LRB- cord-263469-2w26l80a 224 4 DP178 DP178 NNP cord-263469-2w26l80a 224 5 ; ; : cord-263469-2w26l80a 224 6 T20 T20 NNP cord-263469-2w26l80a 224 7 enfuvirtide enfuvirtide NNP cord-263469-2w26l80a 224 8 ) ) -RRB- cord-263469-2w26l80a 224 9 , , , cord-263469-2w26l80a 224 10 one one CD cord-263469-2w26l80a 224 11 of of IN cord-263469-2w26l80a 224 12 these these DT cord-263469-2w26l80a 224 13 peptides peptide NNS cord-263469-2w26l80a 224 14 corresponding correspond VBG cord-263469-2w26l80a 224 15 to to IN cord-263469-2w26l80a 224 16 a a DT cord-263469-2w26l80a 224 17 portion portion NN cord-263469-2w26l80a 224 18 of of IN cord-263469-2w26l80a 224 19 the the DT cord-263469-2w26l80a 224 20 carboxyl carboxyl NN cord-263469-2w26l80a 224 21 terminal terminal NN cord-263469-2w26l80a 224 22 helix helix NN cord-263469-2w26l80a 224 23 and and CC cord-263469-2w26l80a 224 24 the the DT cord-263469-2w26l80a 224 25 pre pre JJ cord-263469-2w26l80a 224 26 - - JJ cord-263469-2w26l80a 224 27 anchor anchor JJ cord-263469-2w26l80a 224 28 domain domain NN cord-263469-2w26l80a 224 29 in in IN cord-263469-2w26l80a 224 30 this this DT cord-263469-2w26l80a 224 31 class class NN cord-263469-2w26l80a 224 32 I -PRON- PRP cord-263469-2w26l80a 224 33 VFP VFP NNP cord-263469-2w26l80a 224 34 , , , cord-263469-2w26l80a 224 35 has have VBZ cord-263469-2w26l80a 224 36 been be VBN cord-263469-2w26l80a 224 37 shown show VBN cord-263469-2w26l80a 224 38 to to TO cord-263469-2w26l80a 224 39 substantially substantially RB cord-263469-2w26l80a 224 40 reduce reduce VB cord-263469-2w26l80a 224 41 HIV-1 HIV-1 NNP cord-263469-2w26l80a 224 42 load load NN cord-263469-2w26l80a 224 43 in in IN cord-263469-2w26l80a 224 44 AIDS AIDS NNP cord-263469-2w26l80a 224 45 patients patient NNS cord-263469-2w26l80a 224 46 , , , cord-263469-2w26l80a 224 47 and and CC cord-263469-2w26l80a 224 48 is be VBZ cord-263469-2w26l80a 224 49 well well RB cord-263469-2w26l80a 224 50 - - HYPH cord-263469-2w26l80a 224 51 established establish VBN cord-263469-2w26l80a 224 52 in in IN cord-263469-2w26l80a 224 53 the the DT cord-263469-2w26l80a 224 54 treatment treatment NN cord-263469-2w26l80a 224 55 of of IN cord-263469-2w26l80a 224 56 HIV HIV NNP cord-263469-2w26l80a 224 57 infection infection NN cord-263469-2w26l80a 224 58 in in IN cord-263469-2w26l80a 224 59 the the DT cord-263469-2w26l80a 224 60 United United NNP cord-263469-2w26l80a 224 61 States States NNP cord-263469-2w26l80a 224 62 and and CC cord-263469-2w26l80a 224 63 European European NNP cord-263469-2w26l80a 224 64 Union Union NNP cord-263469-2w26l80a 224 65 [ [ -LRB- cord-263469-2w26l80a 224 66 48 48 CD cord-263469-2w26l80a 224 67 ] ] -RRB- cord-263469-2w26l80a 224 68 . . . cord-263469-2w26l80a 225 1 Peptide peptide NN cord-263469-2w26l80a 225 2 entry entry NN cord-263469-2w26l80a 225 3 inhibitors inhibitor NNS cord-263469-2w26l80a 225 4 of of IN cord-263469-2w26l80a 225 5 viruses virus NNS cord-263469-2w26l80a 225 6 with with IN cord-263469-2w26l80a 225 7 class class NN cord-263469-2w26l80a 225 8 II II NNP cord-263469-2w26l80a 225 9 VFP VFP NNP cord-263469-2w26l80a 225 10 have have VBP cord-263469-2w26l80a 225 11 also also RB cord-263469-2w26l80a 225 12 been be VBN cord-263469-2w26l80a 225 13 developed develop VBN cord-263469-2w26l80a 225 14 [ [ -LRB- cord-263469-2w26l80a 225 15 49 49 CD cord-263469-2w26l80a 225 16 ] ] -RRB- cord-263469-2w26l80a 225 17 , , , cord-263469-2w26l80a 225 18 and and CC cord-263469-2w26l80a 225 19 have have VBP cord-263469-2w26l80a 225 20 also also RB cord-263469-2w26l80a 225 21 been be VBN cord-263469-2w26l80a 225 22 described describe VBN cord-263469-2w26l80a 225 23 for for IN cord-263469-2w26l80a 225 24 the the DT cord-263469-2w26l80a 225 25 class class NN cord-263469-2w26l80a 225 26 III III NNP cord-263469-2w26l80a 225 27 VFP VFP NNP cord-263469-2w26l80a 225 28 of of IN cord-263469-2w26l80a 225 29 herpesviruses herpesviruses NNP cord-263469-2w26l80a 226 1 ( ( -LRB- cord-263469-2w26l80a 226 2 Melnik Melnik NNP cord-263469-2w26l80a 226 3 et et FW cord-263469-2w26l80a 226 4 al al NNP cord-263469-2w26l80a 226 5 . . NNP cord-263469-2w26l80a 226 6 , , , cord-263469-2w26l80a 226 7 in in IN cord-263469-2w26l80a 226 8 preparation preparation NN cord-263469-2w26l80a 226 9 ) ) -RRB- cord-263469-2w26l80a 226 10 . . . cord-263469-2w26l80a 227 1 Given give VBN cord-263469-2w26l80a 227 2 that that IN cord-263469-2w26l80a 227 3 bornaviruses bornaviruse NNS cord-263469-2w26l80a 227 4 cause cause VBP cord-263469-2w26l80a 227 5 a a DT cord-263469-2w26l80a 227 6 range range NN cord-263469-2w26l80a 227 7 of of IN cord-263469-2w26l80a 227 8 infectious infectious JJ cord-263469-2w26l80a 227 9 neurological neurological JJ cord-263469-2w26l80a 227 10 syndromes syndrome NNS cord-263469-2w26l80a 227 11 in in IN cord-263469-2w26l80a 227 12 warmblooded warmblooded JJ cord-263469-2w26l80a 227 13 animals animal NNS cord-263469-2w26l80a 227 14 , , , cord-263469-2w26l80a 227 15 with with IN cord-263469-2w26l80a 227 16 high high JJ cord-263469-2w26l80a 227 17 mortality mortality NN cord-263469-2w26l80a 227 18 rates rate NNS cord-263469-2w26l80a 227 19 , , , cord-263469-2w26l80a 227 20 veterinary veterinary JJ cord-263469-2w26l80a 227 21 applications application NNS cord-263469-2w26l80a 227 22 of of IN cord-263469-2w26l80a 227 23 bornavirus bornavirus NNP cord-263469-2w26l80a 227 24 entry entry NN cord-263469-2w26l80a 227 25 inhibitors inhibitor NNS cord-263469-2w26l80a 227 26 , , , cord-263469-2w26l80a 227 27 should should MD cord-263469-2w26l80a 227 28 be be VB cord-263469-2w26l80a 227 29 investigated investigate VBN cord-263469-2w26l80a 227 30 . . . cord-263469-2w26l80a 228 1 Confirmation confirmation NN cord-263469-2w26l80a 228 2 of of IN cord-263469-2w26l80a 228 3 the the DT cord-263469-2w26l80a 228 4 still still RB cord-263469-2w26l80a 228 5 controversial controversial JJ cord-263469-2w26l80a 228 6 proposal proposal NN cord-263469-2w26l80a 228 7 that that IN cord-263469-2w26l80a 228 8 bornaviruses bornaviruses NNP cord-263469-2w26l80a 228 9 cause cause VBP cord-263469-2w26l80a 228 10 neuropsyciatric neuropsyciatric JJ cord-263469-2w26l80a 228 11 disorders disorder NNS cord-263469-2w26l80a 228 12 in in IN cord-263469-2w26l80a 228 13 Acquisition Acquisition NNP cord-263469-2w26l80a 228 14 of of IN cord-263469-2w26l80a 228 15 class class NNP cord-263469-2w26l80a 229 1 I -PRON- PRP cord-263469-2w26l80a 229 2 or or CC cord-263469-2w26l80a 229 3 III III NNP cord-263469-2w26l80a 229 4 VFP VFP NNP cord-263469-2w26l80a 229 5 by by IN cord-263469-2w26l80a 229 6 members member NNS cord-263469-2w26l80a 229 7 of of IN cord-263469-2w26l80a 229 8 the the DT cord-263469-2w26l80a 229 9 order order NN cord-263469-2w26l80a 229 10 Mononegavirales Mononegavirales NNP cord-263469-2w26l80a 229 11 Figure Figure NNP cord-263469-2w26l80a 229 12 4 4 CD cord-263469-2w26l80a 229 13 Acquisition Acquisition NNP cord-263469-2w26l80a 229 14 of of IN cord-263469-2w26l80a 229 15 class class NN cord-263469-2w26l80a 230 1 I -PRON- PRP cord-263469-2w26l80a 230 2 or or CC cord-263469-2w26l80a 230 3 III III NNP cord-263469-2w26l80a 230 4 VFP VFP NNP cord-263469-2w26l80a 230 5 by by IN cord-263469-2w26l80a 230 6 members member NNS cord-263469-2w26l80a 230 7 of of IN cord-263469-2w26l80a 230 8 the the DT cord-263469-2w26l80a 230 9 order order NN cord-263469-2w26l80a 230 10 Mononegavirales Mononegavirales NNP cord-263469-2w26l80a 230 11 . . . cord-263469-2w26l80a 231 1 Thick thick JJ cord-263469-2w26l80a 231 2 lines line NNS cord-263469-2w26l80a 231 3 indicate indicate VBP cord-263469-2w26l80a 231 4 primordial primordial JJ cord-263469-2w26l80a 231 5 lineages lineage NNS cord-263469-2w26l80a 231 6 and and CC cord-263469-2w26l80a 231 7 thin thin JJ cord-263469-2w26l80a 231 8 lines line NNS cord-263469-2w26l80a 231 9 are be VBP cord-263469-2w26l80a 231 10 lineages lineage NNS cord-263469-2w26l80a 231 11 leading lead VBG cord-263469-2w26l80a 231 12 to to IN cord-263469-2w26l80a 231 13 contemporary contemporary JJ cord-263469-2w26l80a 231 14 viruses virus NNS cord-263469-2w26l80a 231 15 . . . cord-263469-2w26l80a 232 1 The the DT cord-263469-2w26l80a 232 2 alternative alternative NN cord-263469-2w26l80a 232 3 in in IN cord-263469-2w26l80a 232 4 Panel Panel NNP cord-263469-2w26l80a 232 5 A A NNP cord-263469-2w26l80a 232 6 shows show VBZ cord-263469-2w26l80a 232 7 a a DT cord-263469-2w26l80a 232 8 tree tree NN cord-263469-2w26l80a 232 9 that that WDT cord-263469-2w26l80a 232 10 is be VBZ cord-263469-2w26l80a 232 11 rooted root VBN cord-263469-2w26l80a 232 12 , , , cord-263469-2w26l80a 232 13 with with IN cord-263469-2w26l80a 232 14 the the DT cord-263469-2w26l80a 232 15 glycoproteins glycoprotein NNS cord-263469-2w26l80a 232 16 of of IN cord-263469-2w26l80a 232 17 all all DT cord-263469-2w26l80a 232 18 viral viral JJ cord-263469-2w26l80a 232 19 families family NNS cord-263469-2w26l80a 232 20 evolved evolve VBD cord-263469-2w26l80a 232 21 from from IN cord-263469-2w26l80a 232 22 a a DT cord-263469-2w26l80a 232 23 common common JJ cord-263469-2w26l80a 232 24 class class NN cord-263469-2w26l80a 232 25 I i NN cord-263469-2w26l80a 232 26 , , , cord-263469-2w26l80a 232 27 II II NNP cord-263469-2w26l80a 232 28 and and CC cord-263469-2w26l80a 232 29 III iii CD cord-263469-2w26l80a 232 30 progenitor progenitor NN cord-263469-2w26l80a 232 31 . . . cord-263469-2w26l80a 233 1 Panel Panel NNP cord-263469-2w26l80a 233 2 B B NNP cord-263469-2w26l80a 233 3 shows show VBZ cord-263469-2w26l80a 233 4 another another DT cord-263469-2w26l80a 233 5 possible possible JJ cord-263469-2w26l80a 233 6 evolutionary evolutionary JJ cord-263469-2w26l80a 233 7 tree tree NN cord-263469-2w26l80a 233 8 , , , cord-263469-2w26l80a 233 9 which which WDT cord-263469-2w26l80a 233 10 is be VBZ cord-263469-2w26l80a 233 11 unrooted unroote VBN cord-263469-2w26l80a 233 12 , , , cord-263469-2w26l80a 233 13 and and CC cord-263469-2w26l80a 233 14 depicts depict VBZ cord-263469-2w26l80a 233 15 independent independent JJ cord-263469-2w26l80a 233 16 acquisitions acquisition NNS cord-263469-2w26l80a 233 17 of of IN cord-263469-2w26l80a 233 18 class class NN cord-263469-2w26l80a 233 19 I -PRON- PRP cord-263469-2w26l80a 233 20 VFP VFP NNP cord-263469-2w26l80a 233 21 by by IN cord-263469-2w26l80a 233 22 an an DT cord-263469-2w26l80a 233 23 ancestral ancestral JJ cord-263469-2w26l80a 233 24 paramyxoviruses paramyxovirus NNS cord-263469-2w26l80a 233 25 and and CC cord-263469-2w26l80a 233 26 class class NN cord-263469-2w26l80a 233 27 III III NNP cord-263469-2w26l80a 233 28 VFP vfp NN cord-263469-2w26l80a 233 29 of of IN cord-263469-2w26l80a 233 30 a a DT cord-263469-2w26l80a 233 31 common common JJ cord-263469-2w26l80a 233 32 ancestor ancestor NN cord-263469-2w26l80a 233 33 of of IN cord-263469-2w26l80a 233 34 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 233 35 and and CC cord-263469-2w26l80a 233 36 bornaviruses bornaviruse NNS cord-263469-2w26l80a 233 37 . . . cord-263469-2w26l80a 234 1 A a DT cord-263469-2w26l80a 234 2 variation variation NN cord-263469-2w26l80a 234 3 of of IN cord-263469-2w26l80a 234 4 this this DT cord-263469-2w26l80a 234 5 former former JJ cord-263469-2w26l80a 234 6 tree tree NN cord-263469-2w26l80a 234 7 ( ( -LRB- cord-263469-2w26l80a 234 8 not not RB cord-263469-2w26l80a 234 9 shown show VBN cord-263469-2w26l80a 234 10 ) ) -RRB- cord-263469-2w26l80a 234 11 would would MD cord-263469-2w26l80a 234 12 involve involve VB cord-263469-2w26l80a 234 13 separate separate JJ cord-263469-2w26l80a 234 14 acquisitions acquisition NNS cord-263469-2w26l80a 234 15 of of IN cord-263469-2w26l80a 234 16 class class NN cord-263469-2w26l80a 234 17 III III NNP cord-263469-2w26l80a 234 18 VFP VFP NNP cord-263469-2w26l80a 234 19 by by IN cord-263469-2w26l80a 234 20 ancestral ancestral JJ cord-263469-2w26l80a 234 21 rhabdoviruses rhabdovirus NNS cord-263469-2w26l80a 234 22 and and CC cord-263469-2w26l80a 234 23 bornaviruses bornaviruse NNS cord-263469-2w26l80a 234 24 . . . cord-263469-2w26l80a 234 25 _SP cord-263469-2w26l80a 235 1 The the DT cord-263469-2w26l80a 235 2 biology biology NN cord-263469-2w26l80a 235 3 of of IN cord-263469-2w26l80a 235 4 bornavirus bornavirus NNP cord-263469-2w26l80a 235 5 Recovery Recovery NNP cord-263469-2w26l80a 235 6 of of IN cord-263469-2w26l80a 235 7 divergent divergent JJ cord-263469-2w26l80a 235 8 avian avian JJ cord-263469-2w26l80a 235 9 bornaviruses bornaviruse NNS cord-263469-2w26l80a 235 10 from from IN cord-263469-2w26l80a 235 11 cases case NNS cord-263469-2w26l80a 235 12 of of IN cord-263469-2w26l80a 235 13 proventricular proventricular JJ cord-263469-2w26l80a 235 14 dilatation dilatation NN cord-263469-2w26l80a 235 15 disease disease NN cord-263469-2w26l80a 235 16 : : : cord-263469-2w26l80a 235 17 identification identification NN cord-263469-2w26l80a 235 18 of of IN cord-263469-2w26l80a 235 19 a a DT cord-263469-2w26l80a 235 20 candidate candidate NN cord-263469-2w26l80a 235 21 etiologic etiologic NNP cord-263469-2w26l80a 235 22 agent agent NN cord-263469-2w26l80a 235 23 Experimental Experimental NNP cord-263469-2w26l80a 235 24 induction induction NN cord-263469-2w26l80a 235 25 of of IN cord-263469-2w26l80a 235 26 proventricular proventricular JJ cord-263469-2w26l80a 235 27 dilatation dilatation NN cord-263469-2w26l80a 235 28 disease disease NN cord-263469-2w26l80a 235 29 in in IN cord-263469-2w26l80a 235 30 cockatiels cockatiel NNS cord-263469-2w26l80a 235 31 ( ( -LRB- cord-263469-2w26l80a 235 32 Nymphicus Nymphicus NNP cord-263469-2w26l80a 235 33 hollandicus hollandicus NNP cord-263469-2w26l80a 235 34 ) ) -RRB- cord-263469-2w26l80a 235 35 inoculated inoculate VBN cord-263469-2w26l80a 235 36 with with IN cord-263469-2w26l80a 235 37 brain brain NN cord-263469-2w26l80a 235 38 homogenates homogenate NNS cord-263469-2w26l80a 235 39 containing contain VBG cord-263469-2w26l80a 235 40 avian avian JJ cord-263469-2w26l80a 235 41 bornavirus bornavirus NNP cord-263469-2w26l80a 235 42 4 4 CD cord-263469-2w26l80a 235 43 Borna Borna NNP cord-263469-2w26l80a 235 44 disease disease NN cord-263469-2w26l80a 235 45 virus virus NN cord-263469-2w26l80a 235 46 : : : cord-263469-2w26l80a 235 47 implications implication NNS cord-263469-2w26l80a 235 48 for for IN cord-263469-2w26l80a 235 49 human human JJ cord-263469-2w26l80a 235 50 neuropsychiatric neuropsychiatric JJ cord-263469-2w26l80a 235 51 illness illness NN cord-263469-2w26l80a 235 52 Human Human NNP cord-263469-2w26l80a 235 53 Borna Borna NNP cord-263469-2w26l80a 235 54 disease disease NN cord-263469-2w26l80a 235 55 virus virus NN cord-263469-2w26l80a 235 56 - - : cord-263469-2w26l80a 235 57 infection infection NN cord-263469-2w26l80a 235 58 and and CC cord-263469-2w26l80a 235 59 its -PRON- PRP$ cord-263469-2w26l80a 235 60 therapy therapy NN cord-263469-2w26l80a 235 61 in in IN cord-263469-2w26l80a 235 62 affective affective JJ cord-263469-2w26l80a 235 63 disorders disorder NNS cord-263469-2w26l80a 235 64 Molecular molecular JJ cord-263469-2w26l80a 235 65 biology biology NN cord-263469-2w26l80a 235 66 of of IN cord-263469-2w26l80a 235 67 Borna Borna NNP cord-263469-2w26l80a 235 68 disease disease NN cord-263469-2w26l80a 235 69 virus virus NN cord-263469-2w26l80a 235 70 Molecular molecular JJ cord-263469-2w26l80a 235 71 biology biology NN cord-263469-2w26l80a 235 72 of of IN cord-263469-2w26l80a 235 73 Borna Borna NNP cord-263469-2w26l80a 235 74 disease disease NN cord-263469-2w26l80a 235 75 virus virus NN cord-263469-2w26l80a 235 76 and and CC cord-263469-2w26l80a 235 77 persistence persistence NN cord-263469-2w26l80a 235 78 Pathogenesis Pathogenesis NNP cord-263469-2w26l80a 235 79 of of IN cord-263469-2w26l80a 235 80 Borna Borna NNP cord-263469-2w26l80a 235 81 disease disease NN cord-263469-2w26l80a 235 82 in in IN cord-263469-2w26l80a 235 83 rats rat NNS cord-263469-2w26l80a 235 84 : : : cord-263469-2w26l80a 235 85 evidence evidence NN cord-263469-2w26l80a 235 86 that that IN cord-263469-2w26l80a 235 87 intraaxonal intraaxonal NNP cord-263469-2w26l80a 235 88 spread spread NNP cord-263469-2w26l80a 235 89 is be VBZ cord-263469-2w26l80a 235 90 the the DT cord-263469-2w26l80a 235 91 major major JJ cord-263469-2w26l80a 235 92 route route NN cord-263469-2w26l80a 235 93 for for IN cord-263469-2w26l80a 235 94 virus virus NN cord-263469-2w26l80a 235 95 dissemination dissemination NN cord-263469-2w26l80a 235 96 and and CC cord-263469-2w26l80a 235 97 the the DT cord-263469-2w26l80a 235 98 determinant determinant NN cord-263469-2w26l80a 235 99 for for IN cord-263469-2w26l80a 235 100 disease disease NN cord-263469-2w26l80a 235 101 incubation incubation NN cord-263469-2w26l80a 235 102 Cell cell NN cord-263469-2w26l80a 235 103 - - HYPH cord-263469-2w26l80a 235 104 to to IN cord-263469-2w26l80a 235 105 - - HYPH cord-263469-2w26l80a 235 106 cell cell NN cord-263469-2w26l80a 235 107 spread spread NN cord-263469-2w26l80a 235 108 of of IN cord-263469-2w26l80a 235 109 Borna Borna NNP cord-263469-2w26l80a 235 110 disease disease NN cord-263469-2w26l80a 235 111 virus virus NN cord-263469-2w26l80a 235 112 proceeds proceed VBZ cord-263469-2w26l80a 235 113 in in IN cord-263469-2w26l80a 235 114 the the DT cord-263469-2w26l80a 235 115 absence absence NN cord-263469-2w26l80a 235 116 of of IN cord-263469-2w26l80a 235 117 the the DT cord-263469-2w26l80a 235 118 virus virus NN cord-263469-2w26l80a 235 119 primary primary JJ cord-263469-2w26l80a 235 120 receptor receptor NN cord-263469-2w26l80a 235 121 and and CC cord-263469-2w26l80a 235 122 furin furin NN cord-263469-2w26l80a 235 123 - - HYPH cord-263469-2w26l80a 235 124 mediated mediate VBN cord-263469-2w26l80a 235 125 processing processing NN cord-263469-2w26l80a 235 126 of of IN cord-263469-2w26l80a 235 127 the the DT cord-263469-2w26l80a 235 128 virus virus NN cord-263469-2w26l80a 235 129 surface surface NN cord-263469-2w26l80a 235 130 glycoprotein glycoprotein NN cord-263469-2w26l80a 235 131 Mechanism Mechanism NNP cord-263469-2w26l80a 235 132 of of IN cord-263469-2w26l80a 235 133 Borna Borna NNP cord-263469-2w26l80a 235 134 disease disease NN cord-263469-2w26l80a 235 135 virus virus NN cord-263469-2w26l80a 235 136 entry entry NN cord-263469-2w26l80a 235 137 into into IN cord-263469-2w26l80a 235 138 cells cell NNS cord-263469-2w26l80a 235 139 Processing processing NN cord-263469-2w26l80a 235 140 of of IN cord-263469-2w26l80a 235 141 the the DT cord-263469-2w26l80a 235 142 Borna Borna NNP cord-263469-2w26l80a 235 143 disease disease NN cord-263469-2w26l80a 235 144 virus virus NN cord-263469-2w26l80a 235 145 glycoprotein glycoprotein NN cord-263469-2w26l80a 235 146 gp94 gp94 VBG cord-263469-2w26l80a 235 147 by by IN cord-263469-2w26l80a 235 148 the the DT cord-263469-2w26l80a 235 149 subtilisin subtilisin NNP cord-263469-2w26l80a 235 150 - - HYPH cord-263469-2w26l80a 235 151 like like JJ cord-263469-2w26l80a 235 152 endoprotease endoprotease NN cord-263469-2w26l80a 236 1 furin furin NNP cord-263469-2w26l80a 236 2 Identification identification NN cord-263469-2w26l80a 236 3 of of IN cord-263469-2w26l80a 236 4 the the DT cord-263469-2w26l80a 236 5 amino amino NN cord-263469-2w26l80a 236 6 terminal terminal NN cord-263469-2w26l80a 236 7 subunit subunit NN cord-263469-2w26l80a 236 8 of of IN cord-263469-2w26l80a 236 9 the the DT cord-263469-2w26l80a 236 10 glycoprotein glycoprotein NN cord-263469-2w26l80a 236 11 of of IN cord-263469-2w26l80a 236 12 Borna Borna NNP cord-263469-2w26l80a 236 13 disease disease NN cord-263469-2w26l80a 236 14 virus virus NN cord-263469-2w26l80a 236 15 Maturation Maturation NNP cord-263469-2w26l80a 236 16 of of IN cord-263469-2w26l80a 236 17 Borna Borna NNP cord-263469-2w26l80a 236 18 disease disease NN cord-263469-2w26l80a 236 19 virus virus NN cord-263469-2w26l80a 236 20 glycoprotein glycoprotein NN cord-263469-2w26l80a 236 21 Inhibition inhibition NN cord-263469-2w26l80a 236 22 of of IN cord-263469-2w26l80a 236 23 Borna Borna NNP cord-263469-2w26l80a 236 24 disease disease NN cord-263469-2w26l80a 236 25 virus virus NN cord-263469-2w26l80a 236 26 - - HYPH cord-263469-2w26l80a 236 27 mediated mediate VBN cord-263469-2w26l80a 236 28 cell cell NN cord-263469-2w26l80a 236 29 fusion fusion NN cord-263469-2w26l80a 236 30 by by IN cord-263469-2w26l80a 236 31 monoclonal monoclonal JJ cord-263469-2w26l80a 236 32 antibodies antibody NNS cord-263469-2w26l80a 236 33 directed direct VBN cord-263469-2w26l80a 236 34 against against IN cord-263469-2w26l80a 236 35 the the DT cord-263469-2w26l80a 236 36 viral viral JJ cord-263469-2w26l80a 236 37 glycoprotein glycoprotein NN cord-263469-2w26l80a 236 38 N n CD cord-263469-2w26l80a 236 39 - - HYPH cord-263469-2w26l80a 236 40 terminal terminal NN cord-263469-2w26l80a 236 41 domain domain NN cord-263469-2w26l80a 236 42 of of IN cord-263469-2w26l80a 236 43 Borna Borna NNP cord-263469-2w26l80a 236 44 disease disease NN cord-263469-2w26l80a 236 45 virus virus NN cord-263469-2w26l80a 236 46 G g NN cord-263469-2w26l80a 236 47 ( ( -LRB- cord-263469-2w26l80a 236 48 p56 p56 NN cord-263469-2w26l80a 236 49 ) ) -RRB- cord-263469-2w26l80a 236 50 protein protein NN cord-263469-2w26l80a 236 51 is be VBZ cord-263469-2w26l80a 236 52 sufficient sufficient JJ cord-263469-2w26l80a 236 53 for for IN cord-263469-2w26l80a 236 54 virus virus NN cord-263469-2w26l80a 236 55 receptor receptor NN cord-263469-2w26l80a 236 56 recognition recognition NN cord-263469-2w26l80a 236 57 and and CC cord-263469-2w26l80a 236 58 cell cell NN cord-263469-2w26l80a 236 59 entry entry NN cord-263469-2w26l80a 236 60 Structure Structure NNP cord-263469-2w26l80a 236 61 of of IN cord-263469-2w26l80a 236 62 the the DT cord-263469-2w26l80a 236 63 haemagglutinin haemagglutinin NNP cord-263469-2w26l80a 236 64 membrane membrane NN cord-263469-2w26l80a 236 65 glycoprotein glycoprotein NN cord-263469-2w26l80a 236 66 of of IN cord-263469-2w26l80a 236 67 influenza influenza NN cord-263469-2w26l80a 236 68 virus virus NN cord-263469-2w26l80a 236 69 at at IN cord-263469-2w26l80a 236 70 3 3 CD cord-263469-2w26l80a 236 71 A a DT cord-263469-2w26l80a 236 72 resolution resolution NN cord-263469-2w26l80a 236 73 A a DT cord-263469-2w26l80a 236 74 general general JJ cord-263469-2w26l80a 236 75 model model NN cord-263469-2w26l80a 236 76 for for IN cord-263469-2w26l80a 236 77 the the DT cord-263469-2w26l80a 236 78 transmembrane transmembrane NN cord-263469-2w26l80a 236 79 proteins protein NNS cord-263469-2w26l80a 236 80 of of IN cord-263469-2w26l80a 236 81 HIV HIV NNP cord-263469-2w26l80a 236 82 and and CC cord-263469-2w26l80a 236 83 other other JJ cord-263469-2w26l80a 236 84 retroviruses retrovirus NNS cord-263469-2w26l80a 237 1 Similar similar JJ cord-263469-2w26l80a 237 2 structural structural JJ cord-263469-2w26l80a 237 3 models model NNS cord-263469-2w26l80a 237 4 of of IN cord-263469-2w26l80a 237 5 the the DT cord-263469-2w26l80a 237 6 transmembrane transmembrane NN cord-263469-2w26l80a 237 7 proteins protein NNS cord-263469-2w26l80a 237 8 of of IN cord-263469-2w26l80a 237 9 Ebola Ebola NNP cord-263469-2w26l80a 237 10 and and CC cord-263469-2w26l80a 237 11 avian avian JJ cord-263469-2w26l80a 237 12 sarcoma sarcoma NN cord-263469-2w26l80a 237 13 viruses virus NNS cord-263469-2w26l80a 237 14 Atomic atomic JJ cord-263469-2w26l80a 237 15 structure structure NN cord-263469-2w26l80a 237 16 of of IN cord-263469-2w26l80a 237 17 the the DT cord-263469-2w26l80a 237 18 ectodomain ectodomain NN cord-263469-2w26l80a 237 19 from from IN cord-263469-2w26l80a 237 20 HIV-1 HIV-1 NNP cord-263469-2w26l80a 237 21 gp41 gp41 NNP cord-263469-2w26l80a 238 1 The the DT cord-263469-2w26l80a 238 2 viral viral JJ cord-263469-2w26l80a 238 3 transmembrane transmembrane NN cord-263469-2w26l80a 238 4 superfamily superfamily NN cord-263469-2w26l80a 238 5 : : : cord-263469-2w26l80a 238 6 possible possible JJ cord-263469-2w26l80a 238 7 divergence divergence NN cord-263469-2w26l80a 238 8 of of IN cord-263469-2w26l80a 238 9 Arenavirus Arenavirus NNP cord-263469-2w26l80a 238 10 and and CC cord-263469-2w26l80a 238 11 Filovirus Filovirus NNP cord-263469-2w26l80a 238 12 glycoproteins glycoprotein NNS cord-263469-2w26l80a 238 13 from from IN cord-263469-2w26l80a 238 14 a a DT cord-263469-2w26l80a 238 15 common common JJ cord-263469-2w26l80a 238 16 RNA RNA NNP cord-263469-2w26l80a 238 17 virus virus NN cord-263469-2w26l80a 238 18 ancestor ancestor NN cord-263469-2w26l80a 238 19 Model Model NNP cord-263469-2w26l80a 238 20 of of IN cord-263469-2w26l80a 238 21 the the DT cord-263469-2w26l80a 238 22 pre pre JJ cord-263469-2w26l80a 238 23 - - JJ cord-263469-2w26l80a 238 24 insertion insertion JJ cord-263469-2w26l80a 238 25 region region NN cord-263469-2w26l80a 238 26 of of IN cord-263469-2w26l80a 238 27 the the DT cord-263469-2w26l80a 238 28 spike spike NN cord-263469-2w26l80a 238 29 ( ( -LRB- cord-263469-2w26l80a 238 30 S2 S2 NNP cord-263469-2w26l80a 238 31 ) ) -RRB- cord-263469-2w26l80a 238 32 fusion fusion NN cord-263469-2w26l80a 238 33 glycoprotein glycoprotein NN cord-263469-2w26l80a 238 34 of of IN cord-263469-2w26l80a 238 35 the the DT cord-263469-2w26l80a 238 36 human human JJ cord-263469-2w26l80a 238 37 SARS SARS NNP cord-263469-2w26l80a 238 38 coronavirus coronavirus NN cord-263469-2w26l80a 238 39 : : : cord-263469-2w26l80a 238 40 Implications implication NNS cord-263469-2w26l80a 238 41 for for IN cord-263469-2w26l80a 238 42 antiviral antiviral JJ cord-263469-2w26l80a 238 43 therapeutics therapeutic NNS cord-263469-2w26l80a 238 44 Detection Detection NNP cord-263469-2w26l80a 238 45 of of IN cord-263469-2w26l80a 238 46 a a DT cord-263469-2w26l80a 238 47 fusion fusion NN cord-263469-2w26l80a 238 48 peptide peptide NN cord-263469-2w26l80a 238 49 sequence sequence NN cord-263469-2w26l80a 238 50 in in IN cord-263469-2w26l80a 238 51 the the DT cord-263469-2w26l80a 238 52 transmembrane transmembrane NNP cord-263469-2w26l80a 238 53 protein protein NN cord-263469-2w26l80a 238 54 of of IN cord-263469-2w26l80a 238 55 human human JJ cord-263469-2w26l80a 238 56 immunodeficiency immunodeficiency NN cord-263469-2w26l80a 238 57 virus virus NN cord-263469-2w26l80a 238 58 Identification identification NN cord-263469-2w26l80a 238 59 and and CC cord-263469-2w26l80a 238 60 characterization characterization NN cord-263469-2w26l80a 238 61 of of IN cord-263469-2w26l80a 238 62 the the DT cord-263469-2w26l80a 238 63 putative putative JJ cord-263469-2w26l80a 238 64 fusion fusion NN cord-263469-2w26l80a 238 65 peptide peptide NN cord-263469-2w26l80a 238 66 of of IN cord-263469-2w26l80a 238 67 the the DT cord-263469-2w26l80a 238 68 severe severe JJ cord-263469-2w26l80a 238 69 acute acute JJ cord-263469-2w26l80a 238 70 respiratory respiratory JJ cord-263469-2w26l80a 238 71 syndrome syndrome NN cord-263469-2w26l80a 238 72 - - HYPH cord-263469-2w26l80a 238 73 associated associate VBN cord-263469-2w26l80a 238 74 coronavirus coronavirus NN cord-263469-2w26l80a 238 75 spike spike NN cord-263469-2w26l80a 238 76 protein protein NN cord-263469-2w26l80a 238 77 The the DT cord-263469-2w26l80a 238 78 envelope envelope NN cord-263469-2w26l80a 238 79 glycoprotein glycoprotein NN cord-263469-2w26l80a 238 80 from from IN cord-263469-2w26l80a 238 81 tick tick NN cord-263469-2w26l80a 238 82 - - HYPH cord-263469-2w26l80a 238 83 borne bear VBN cord-263469-2w26l80a 238 84 encephalitis encephalitis JJ cord-263469-2w26l80a 238 85 virus virus NN cord-263469-2w26l80a 238 86 at at IN cord-263469-2w26l80a 238 87 2 2 CD cord-263469-2w26l80a 238 88 A a DT cord-263469-2w26l80a 238 89 resolution resolution NN cord-263469-2w26l80a 238 90 Structure structure NN cord-263469-2w26l80a 238 91 of of IN cord-263469-2w26l80a 238 92 the the DT cord-263469-2w26l80a 238 93 dengue dengue NN cord-263469-2w26l80a 238 94 virus virus NN cord-263469-2w26l80a 238 95 envelope envelope NN cord-263469-2w26l80a 238 96 protein protein NN cord-263469-2w26l80a 238 97 after after IN cord-263469-2w26l80a 238 98 membrane membrane NN cord-263469-2w26l80a 238 99 fusion fusion NN cord-263469-2w26l80a 238 100 Conformational Conformational NNP cord-263469-2w26l80a 238 101 change change NN cord-263469-2w26l80a 238 102 and and CC cord-263469-2w26l80a 238 103 protein protein NN cord-263469-2w26l80a 238 104 - - HYPH cord-263469-2w26l80a 238 105 protein protein NN cord-263469-2w26l80a 238 106 interactions interaction NNS cord-263469-2w26l80a 238 107 of of IN cord-263469-2w26l80a 238 108 the the DT cord-263469-2w26l80a 238 109 fusion fusion NN cord-263469-2w26l80a 238 110 protein protein NN cord-263469-2w26l80a 238 111 of of IN cord-263469-2w26l80a 238 112 Semliki Semliki NNP cord-263469-2w26l80a 238 113 Forest Forest NNP cord-263469-2w26l80a 238 114 virus virus NN cord-263469-2w26l80a 238 115 Proteomics Proteomics NNP cord-263469-2w26l80a 238 116 computational computational JJ cord-263469-2w26l80a 238 117 analyses analysis NNS cord-263469-2w26l80a 238 118 suggest suggest VBP cord-263469-2w26l80a 238 119 that that IN cord-263469-2w26l80a 238 120 hepatitis hepatitis NN cord-263469-2w26l80a 238 121 C C NNP cord-263469-2w26l80a 238 122 virus virus NN cord-263469-2w26l80a 238 123 E1 e1 NN cord-263469-2w26l80a 238 124 and and CC cord-263469-2w26l80a 238 125 pestivirus pestivirus NNP cord-263469-2w26l80a 238 126 E2 E2 NNP cord-263469-2w26l80a 238 127 envelope envelope NN cord-263469-2w26l80a 238 128 glycoproteins glycoprotein NNS cord-263469-2w26l80a 238 129 are be VBP cord-263469-2w26l80a 238 130 truncated truncate VBN cord-263469-2w26l80a 238 131 class class NN cord-263469-2w26l80a 238 132 II II NNP cord-263469-2w26l80a 238 133 fusion fusion NN cord-263469-2w26l80a 238 134 proteins protein NNS cord-263469-2w26l80a 239 1 Proteomics Proteomics NNP cord-263469-2w26l80a 239 2 computational computational JJ cord-263469-2w26l80a 239 3 analyses analysis NNS cord-263469-2w26l80a 239 4 suggest suggest VBP cord-263469-2w26l80a 239 5 that that IN cord-263469-2w26l80a 239 6 the the DT cord-263469-2w26l80a 239 7 carboxyl carboxyl NN cord-263469-2w26l80a 239 8 terminal terminal NN cord-263469-2w26l80a 239 9 glycoproteins glycoprotein NNS cord-263469-2w26l80a 239 10 of of IN cord-263469-2w26l80a 239 11 Bunyaviruses Bunyaviruses NNP cord-263469-2w26l80a 239 12 are be VBP cord-263469-2w26l80a 239 13 class class NN cord-263469-2w26l80a 239 14 II ii CD cord-263469-2w26l80a 239 15 viral viral JJ cord-263469-2w26l80a 239 16 fusion fusion NN cord-263469-2w26l80a 239 17 proteins protein NNS cord-263469-2w26l80a 239 18 ( ( -LRB- cord-263469-2w26l80a 239 19 beta beta NN cord-263469-2w26l80a 239 20 - - HYPH cord-263469-2w26l80a 239 21 penetrenes penetrene NNS cord-263469-2w26l80a 239 22 ) ) -RRB- cord-263469-2w26l80a 240 1 California California NNP cord-263469-2w26l80a 240 2 serogroup serogroup NN cord-263469-2w26l80a 240 3 Gc Gc NNP cord-263469-2w26l80a 240 4 ( ( -LRB- cord-263469-2w26l80a 240 5 G1 G1 NNP cord-263469-2w26l80a 240 6 ) ) -RRB- cord-263469-2w26l80a 240 7 glycoprotein glycoprotein NN cord-263469-2w26l80a 240 8 is be VBZ cord-263469-2w26l80a 240 9 the the DT cord-263469-2w26l80a 240 10 principal principal JJ cord-263469-2w26l80a 240 11 determinant determinant NN cord-263469-2w26l80a 240 12 of of IN cord-263469-2w26l80a 240 13 pH ph JJ cord-263469-2w26l80a 240 14 - - HYPH cord-263469-2w26l80a 240 15 dependent dependent JJ cord-263469-2w26l80a 240 16 cell cell NN cord-263469-2w26l80a 240 17 fusion fusion NN cord-263469-2w26l80a 240 18 and and CC cord-263469-2w26l80a 240 19 entry entry NN cord-263469-2w26l80a 240 20 Crystal Crystal NNP cord-263469-2w26l80a 240 21 structure structure NN cord-263469-2w26l80a 240 22 of of IN cord-263469-2w26l80a 240 23 the the DT cord-263469-2w26l80a 240 24 low low JJ cord-263469-2w26l80a 240 25 - - HYPH cord-263469-2w26l80a 240 26 pH ph NN cord-263469-2w26l80a 240 27 form form NN cord-263469-2w26l80a 240 28 of of IN cord-263469-2w26l80a 240 29 the the DT cord-263469-2w26l80a 240 30 vesicular vesicular JJ cord-263469-2w26l80a 240 31 stomatitis stomatitis NN cord-263469-2w26l80a 240 32 virus virus NN cord-263469-2w26l80a 240 33 glycoprotein glycoprotein NN cord-263469-2w26l80a 240 34 G. G. NNP cord-263469-2w26l80a 240 35 Science Science NNP cord-263469-2w26l80a 240 36 Structure Structure NNP cord-263469-2w26l80a 240 37 of of IN cord-263469-2w26l80a 240 38 the the DT cord-263469-2w26l80a 240 39 prefusion prefusion NN cord-263469-2w26l80a 240 40 form form NN cord-263469-2w26l80a 240 41 of of IN cord-263469-2w26l80a 240 42 the the DT cord-263469-2w26l80a 240 43 vesicular vesicular JJ cord-263469-2w26l80a 240 44 stomatitis stomatitis NN cord-263469-2w26l80a 240 45 virus virus NN cord-263469-2w26l80a 240 46 glycoprotein glycoprotein NN cord-263469-2w26l80a 240 47 G G NNP cord-263469-2w26l80a 240 48 Crystal Crystal NNP cord-263469-2w26l80a 240 49 structure structure NN cord-263469-2w26l80a 240 50 of of IN cord-263469-2w26l80a 240 51 glycoprotein glycoprotein NN cord-263469-2w26l80a 240 52 B b NN cord-263469-2w26l80a 240 53 from from IN cord-263469-2w26l80a 240 54 herpes herpes NNP cord-263469-2w26l80a 240 55 simplex simplex NNP cord-263469-2w26l80a 240 56 virus virus NN cord-263469-2w26l80a 241 1 1 1 CD cord-263469-2w26l80a 241 2 Proteomics Proteomics NNP cord-263469-2w26l80a 241 3 computational computational JJ cord-263469-2w26l80a 241 4 analyses analysis NNS cord-263469-2w26l80a 241 5 suggest suggest VBP cord-263469-2w26l80a 241 6 that that IN cord-263469-2w26l80a 241 7 baculovirus baculovirus NNP cord-263469-2w26l80a 241 8 GP64 GP64 NNP cord-263469-2w26l80a 241 9 superfamily superfamily NN cord-263469-2w26l80a 241 10 proteins protein NNS cord-263469-2w26l80a 241 11 are be VBP cord-263469-2w26l80a 241 12 class class NN cord-263469-2w26l80a 241 13 III iii CD cord-263469-2w26l80a 241 14 penetrenes penetrene NNS cord-263469-2w26l80a 242 1 The the DT cord-263469-2w26l80a 242 2 postfusion postfusion NN cord-263469-2w26l80a 242 3 structure structure NN cord-263469-2w26l80a 242 4 of of IN cord-263469-2w26l80a 242 5 baculovirus baculovirus NNP cord-263469-2w26l80a 242 6 gp64 gp64 RB cord-263469-2w26l80a 242 7 supports support VBZ cord-263469-2w26l80a 242 8 a a DT cord-263469-2w26l80a 242 9 unified unified JJ cord-263469-2w26l80a 242 10 view view NN cord-263469-2w26l80a 242 11 of of IN cord-263469-2w26l80a 242 12 viral viral JJ cord-263469-2w26l80a 242 13 fusion fusion NN cord-263469-2w26l80a 242 14 machines machine NNS cord-263469-2w26l80a 242 15 A a DT cord-263469-2w26l80a 242 16 time time NN cord-263469-2w26l80a 242 17 - - HYPH cord-263469-2w26l80a 242 18 efficient efficient JJ cord-263469-2w26l80a 242 19 , , , cord-263469-2w26l80a 242 20 linear linear JJ cord-263469-2w26l80a 242 21 - - HYPH cord-263469-2w26l80a 242 22 space space NN cord-263469-2w26l80a 242 23 local local JJ cord-263469-2w26l80a 242 24 similarity similarity NN cord-263469-2w26l80a 242 25 algorithm algorithm NN cord-263469-2w26l80a 242 26 Prediction Prediction NNP cord-263469-2w26l80a 242 27 in in IN cord-263469-2w26l80a 242 28 1D 1d CD cord-263469-2w26l80a 242 29 : : : cord-263469-2w26l80a 242 30 secondary secondary JJ cord-263469-2w26l80a 242 31 structure structure NN cord-263469-2w26l80a 242 32 , , , cord-263469-2w26l80a 242 33 membrane membrane NN cord-263469-2w26l80a 242 34 helices helix NNS cord-263469-2w26l80a 242 35 , , , cord-263469-2w26l80a 242 36 and and CC cord-263469-2w26l80a 242 37 accessibility accessibility NN cord-263469-2w26l80a 242 38 TMBASE TMBASE NNP cord-263469-2w26l80a 242 39 -A -A NNS cord-263469-2w26l80a 242 40 database database NN cord-263469-2w26l80a 242 41 of of IN cord-263469-2w26l80a 242 42 membrane membrane NN cord-263469-2w26l80a 242 43 spanning span VBG cord-263469-2w26l80a 242 44 protein protein NN cord-263469-2w26l80a 242 45 segments segment NNS cord-263469-2w26l80a 242 46 . . . cord-263469-2w26l80a 243 1 Bological Bological NNP cord-263469-2w26l80a 243 2 Chemistry Chemistry NNP cord-263469-2w26l80a 244 1 Hoppe Hoppe NNP cord-263469-2w26l80a 244 2 - - HYPH cord-263469-2w26l80a 244 3 Seyler Seyler NNP cord-263469-2w26l80a 244 4 Membrane Membrane NNP cord-263469-2w26l80a 244 5 Protein Protein NNP cord-263469-2w26l80a 244 6 Explorer Explorer NNP cord-263469-2w26l80a 244 7 version version NN cord-263469-2w26l80a 244 8 3 3 CD cord-263469-2w26l80a 244 9 Experimentally experimentally RB cord-263469-2w26l80a 244 10 determined determine VBD cord-263469-2w26l80a 244 11 hydrophobicity hydrophobicity NN cord-263469-2w26l80a 244 12 scale scale NN cord-263469-2w26l80a 244 13 for for IN cord-263469-2w26l80a 244 14 proteins protein NNS cord-263469-2w26l80a 244 15 at at IN cord-263469-2w26l80a 244 16 membrane membrane NN cord-263469-2w26l80a 244 17 interfaces interface NNS cord-263469-2w26l80a 245 1 The the DT cord-263469-2w26l80a 245 2 coronavirus coronavirus NN cord-263469-2w26l80a 245 3 spike spike NN cord-263469-2w26l80a 245 4 protein protein NN cord-263469-2w26l80a 245 5 is be VBZ cord-263469-2w26l80a 245 6 a a DT cord-263469-2w26l80a 245 7 class class NN cord-263469-2w26l80a 245 8 I -PRON- PRP cord-263469-2w26l80a 245 9 virus virus NN cord-263469-2w26l80a 245 10 fusion fusion NN cord-263469-2w26l80a 245 11 protein protein NN cord-263469-2w26l80a 245 12 : : : cord-263469-2w26l80a 246 1 structural structural JJ cord-263469-2w26l80a 246 2 and and CC cord-263469-2w26l80a 246 3 functional functional JJ cord-263469-2w26l80a 246 4 characterization characterization NN cord-263469-2w26l80a 246 5 of of IN cord-263469-2w26l80a 246 6 the the DT cord-263469-2w26l80a 246 7 fusion fusion NN cord-263469-2w26l80a 246 8 core core NN cord-263469-2w26l80a 246 9 complex complex NN cord-263469-2w26l80a 246 10 Mapping mapping NN cord-263469-2w26l80a 246 11 of of IN cord-263469-2w26l80a 246 12 functional functional JJ cord-263469-2w26l80a 246 13 elements element NNS cord-263469-2w26l80a 246 14 in in IN cord-263469-2w26l80a 246 15 the the DT cord-263469-2w26l80a 246 16 stem stem NN cord-263469-2w26l80a 246 17 - - HYPH cord-263469-2w26l80a 246 18 anchor anchor NN cord-263469-2w26l80a 246 19 region region NN cord-263469-2w26l80a 246 20 of of IN cord-263469-2w26l80a 246 21 tick tick NN cord-263469-2w26l80a 246 22 - - HYPH cord-263469-2w26l80a 246 23 borne bear VBN cord-263469-2w26l80a 246 24 encephalitis encephalitis JJ cord-263469-2w26l80a 246 25 virus virus NN cord-263469-2w26l80a 246 26 envelope envelope NN cord-263469-2w26l80a 246 27 protein protein NN cord-263469-2w26l80a 246 28 E E NNP cord-263469-2w26l80a 246 29 Mutagenesis Mutagenesis NNP cord-263469-2w26l80a 246 30 of of IN cord-263469-2w26l80a 246 31 a a DT cord-263469-2w26l80a 246 32 conserved conserve VBN cord-263469-2w26l80a 246 33 fusion fusion NN cord-263469-2w26l80a 246 34 peptide peptide NN cord-263469-2w26l80a 246 35 - - HYPH cord-263469-2w26l80a 246 36 like like JJ cord-263469-2w26l80a 246 37 motif motif NN cord-263469-2w26l80a 246 38 and and CC cord-263469-2w26l80a 246 39 membrane membrane NN cord-263469-2w26l80a 246 40 - - HYPH cord-263469-2w26l80a 246 41 proximal proximal JJ cord-263469-2w26l80a 246 42 heptadrepeat heptadrepeat NN cord-263469-2w26l80a 246 43 region region NN cord-263469-2w26l80a 246 44 of of IN cord-263469-2w26l80a 246 45 hepatitis hepatitis NNP cord-263469-2w26l80a 246 46 C C NNP cord-263469-2w26l80a 246 47 virus virus NN cord-263469-2w26l80a 246 48 glycoprotein glycoprotein NN cord-263469-2w26l80a 246 49 E1 E1 NNP cord-263469-2w26l80a 246 50 Structure Structure NNP cord-263469-2w26l80a 246 51 of of IN cord-263469-2w26l80a 246 52 a a DT cord-263469-2w26l80a 246 53 trimeric trimeric JJ cord-263469-2w26l80a 246 54 variant variant NN cord-263469-2w26l80a 246 55 of of IN cord-263469-2w26l80a 246 56 the the DT cord-263469-2w26l80a 246 57 Epstein Epstein NNP cord-263469-2w26l80a 246 58 - - HYPH cord-263469-2w26l80a 246 59 Barr Barr NNP cord-263469-2w26l80a 246 60 virus virus NN cord-263469-2w26l80a 246 61 glycoprotein glycoprotein NN cord-263469-2w26l80a 246 62 B B NNP cord-263469-2w26l80a 246 63 Cell cell NN cord-263469-2w26l80a 246 64 entry entry NN cord-263469-2w26l80a 246 65 of of IN cord-263469-2w26l80a 246 66 Borna Borna NNP cord-263469-2w26l80a 246 67 Disease Disease NNP cord-263469-2w26l80a 246 68 Virus Virus NNP cord-263469-2w26l80a 246 69 follows follow VBZ cord-263469-2w26l80a 246 70 a a DT cord-263469-2w26l80a 246 71 clathrin clathrin NN cord-263469-2w26l80a 246 72 mediated mediate VBN cord-263469-2w26l80a 246 73 endocytosis endocytosis NN cord-263469-2w26l80a 246 74 pathway pathway NN cord-263469-2w26l80a 246 75 that that WDT cord-263469-2w26l80a 246 76 requires require VBZ cord-263469-2w26l80a 246 77 Rab5 Rab5 NNP cord-263469-2w26l80a 246 78 and and CC cord-263469-2w26l80a 246 79 microtubules microtubule VBZ cord-263469-2w26l80a 246 80 Identification identification NN cord-263469-2w26l80a 246 81 of of IN cord-263469-2w26l80a 246 82 an an DT cord-263469-2w26l80a 246 83 N N NNP cord-263469-2w26l80a 246 84 - - HYPH cord-263469-2w26l80a 246 85 Terminal Terminal NNP cord-263469-2w26l80a 246 86 Trimeric Trimeric NNP cord-263469-2w26l80a 246 87 Coiled Coiled NNP cord-263469-2w26l80a 246 88 - - HYPH cord-263469-2w26l80a 246 89 Coil Coil NNP cord-263469-2w26l80a 246 90 Core Core NNP cord-263469-2w26l80a 246 91 within within IN cord-263469-2w26l80a 246 92 Arenavirus Arenavirus NNP cord-263469-2w26l80a 246 93 Glycoprotein Glycoprotein NNP cord-263469-2w26l80a 246 94 2 2 CD cord-263469-2w26l80a 246 95 Permits Permits NNPS cord-263469-2w26l80a 246 96 Assignment Assignment NNP cord-263469-2w26l80a 246 97 to to IN cord-263469-2w26l80a 247 1 Class class NN cord-263469-2w26l80a 247 2 I i NN cord-263469-2w26l80a 247 3 Viral Viral NNP cord-263469-2w26l80a 247 4 Fusion Fusion NNP cord-263469-2w26l80a 247 5 Proteins Proteins NNP cord-263469-2w26l80a 247 6 Characterization characterization NN cord-263469-2w26l80a 247 7 of of IN cord-263469-2w26l80a 247 8 a a DT cord-263469-2w26l80a 247 9 putative putative JJ cord-263469-2w26l80a 247 10 cellular cellular JJ cord-263469-2w26l80a 247 11 receptor receptor NN cord-263469-2w26l80a 247 12 for for IN cord-263469-2w26l80a 247 13 HIV-1 HIV-1 NNP cord-263469-2w26l80a 247 14 transmembrane transmembrane NN cord-263469-2w26l80a 247 15 glycoprotein glycoprotein NN cord-263469-2w26l80a 247 16 using use VBG cord-263469-2w26l80a 247 17 synthetic synthetic JJ cord-263469-2w26l80a 247 18 peptides peptide NNS cord-263469-2w26l80a 247 19 A a DT cord-263469-2w26l80a 247 20 synthetic synthetic JJ cord-263469-2w26l80a 247 21 peptide peptide JJ cord-263469-2w26l80a 247 22 inhibitor inhibitor NN cord-263469-2w26l80a 247 23 of of IN cord-263469-2w26l80a 247 24 human human JJ cord-263469-2w26l80a 247 25 immunodeficiency immunodeficiency NN cord-263469-2w26l80a 247 26 virus virus NN cord-263469-2w26l80a 247 27 replication replication NN cord-263469-2w26l80a 247 28 : : : cord-263469-2w26l80a 247 29 correlation correlation NN cord-263469-2w26l80a 247 30 between between IN cord-263469-2w26l80a 247 31 solution solution NN cord-263469-2w26l80a 247 32 structure structure NN cord-263469-2w26l80a 247 33 and and CC cord-263469-2w26l80a 247 34 viral viral JJ cord-263469-2w26l80a 247 35 inhibition inhibition NN cord-263469-2w26l80a 247 36 Potent potent JJ cord-263469-2w26l80a 247 37 suppression suppression NN cord-263469-2w26l80a 247 38 of of IN cord-263469-2w26l80a 247 39 HIV-1 HIV-1 NNP cord-263469-2w26l80a 247 40 replication replication NN cord-263469-2w26l80a 247 41 in in IN cord-263469-2w26l80a 247 42 humans human NNS cord-263469-2w26l80a 247 43 by by IN cord-263469-2w26l80a 247 44 T-20 T-20 NNP cord-263469-2w26l80a 247 45 , , , cord-263469-2w26l80a 247 46 a a DT cord-263469-2w26l80a 247 47 peptide peptide JJ cord-263469-2w26l80a 247 48 inhibitor inhibitor NN cord-263469-2w26l80a 247 49 of of IN cord-263469-2w26l80a 247 50 gp41-mediated gp41-mediated JJ cord-263469-2w26l80a 247 51 virus virus NN cord-263469-2w26l80a 247 52 entry entry NN cord-263469-2w26l80a 247 53 Peptide Peptide NNP cord-263469-2w26l80a 247 54 inhibitors inhibitor NNS cord-263469-2w26l80a 247 55 of of IN cord-263469-2w26l80a 247 56 dengue dengue NN cord-263469-2w26l80a 247 57 virus virus NN cord-263469-2w26l80a 247 58 and and CC cord-263469-2w26l80a 247 59 West West NNP cord-263469-2w26l80a 247 60 Nile Nile NNP cord-263469-2w26l80a 247 61 virus virus NN cord-263469-2w26l80a 247 62 infectivity infectivity NN cord-263469-2w26l80a 248 1 The the DT cord-263469-2w26l80a 248 2 authors author NNS cord-263469-2w26l80a 248 3 declare declare VBP cord-263469-2w26l80a 248 4 that that IN cord-263469-2w26l80a 248 5 they -PRON- PRP cord-263469-2w26l80a 248 6 have have VBP cord-263469-2w26l80a 248 7 no no DT cord-263469-2w26l80a 248 8 competing compete VBG cord-263469-2w26l80a 248 9 interests interest NNS cord-263469-2w26l80a 248 10 . . . cord-263469-2w26l80a 249 1 CEG CEG NNP cord-263469-2w26l80a 249 2 performed perform VBD cord-263469-2w26l80a 249 3 sequence sequence NN cord-263469-2w26l80a 249 4 alignments alignment NNS cord-263469-2w26l80a 249 5 , , , cord-263469-2w26l80a 249 6 and and CC cord-263469-2w26l80a 249 7 assisted assist VBN cord-263469-2w26l80a 249 8 in in IN cord-263469-2w26l80a 249 9 preparation preparation NN cord-263469-2w26l80a 249 10 of of IN cord-263469-2w26l80a 249 11 figures figure NNS cord-263469-2w26l80a 249 12 . . . cord-263469-2w26l80a 250 1 RFG RFG NNP cord-263469-2w26l80a 250 2 wrote write VBD cord-263469-2w26l80a 250 3 the the DT cord-263469-2w26l80a 250 4 manuscript manuscript NN cord-263469-2w26l80a 250 5 . . . cord-263469-2w26l80a 251 1 Both both DT cord-263469-2w26l80a 251 2 authors author NNS cord-263469-2w26l80a 251 3 read read VBP cord-263469-2w26l80a 251 4 and and CC cord-263469-2w26l80a 251 5 approved approve VBD cord-263469-2w26l80a 251 6 the the DT cord-263469-2w26l80a 251 7 final final JJ cord-263469-2w26l80a 251 8 manuscript manuscript NN cord-263469-2w26l80a 251 9 . . . cord-263469-2w26l80a 252 1 Publish publish VB cord-263469-2w26l80a 252 2 with with IN cord-263469-2w26l80a 252 3 Bio Bio NNP cord-263469-2w26l80a 252 4 Med Med NNP cord-263469-2w26l80a 252 5 Central Central NNP cord-263469-2w26l80a 252 6 and and CC cord-263469-2w26l80a 252 7 every every DT cord-263469-2w26l80a 252 8 scientist scientist NN cord-263469-2w26l80a 252 9 can can MD cord-263469-2w26l80a 252 10 read read VB cord-263469-2w26l80a 252 11 your -PRON- PRP$ cord-263469-2w26l80a 252 12 work work NN cord-263469-2w26l80a 252 13 free free JJ cord-263469-2w26l80a 252 14 of of IN cord-263469-2w26l80a 252 15 charge charge NN cord-263469-2w26l80a 252 16 _SP