id	sid	tid	token	lemma	pos
cord-048466-fj9l8che	1	1	key	key	JJ
cord-048466-fj9l8che	1	2	:	:	:
cord-048466-fj9l8che	1	3	cord-048466-fj9l8che	cord-048466-fj9l8che	NNP
cord-048466-fj9l8che	1	4	authors	author	NNS
cord-048466-fj9l8che	1	5	:	:	:
cord-048466-fj9l8che	1	6	Bragstad	Bragstad	NNP
cord-048466-fj9l8che	1	7	,	,	,
cord-048466-fj9l8che	1	8	Karoline	Karoline	NNP
cord-048466-fj9l8che	1	9	;	;	:
cord-048466-fj9l8che	1	10	Nielsen	Nielsen	NNP
cord-048466-fj9l8che	1	11	,	,	,
cord-048466-fj9l8che	1	12	Lars	Lars	NNP
cord-048466-fj9l8che	1	13	P	P	NNP
cord-048466-fj9l8che	1	14	;	;	:
cord-048466-fj9l8che	1	15	Fomsgaard	Fomsgaard	NNP
cord-048466-fj9l8che	1	16	,	,	,
cord-048466-fj9l8che	1	17	Anders	Anders	NNP
cord-048466-fj9l8che	1	18	title	title	NN
cord-048466-fj9l8che	1	19	:	:	:
cord-048466-fj9l8che	1	20	The	the	DT
cord-048466-fj9l8che	1	21	evolution	evolution	NN
cord-048466-fj9l8che	1	22	of	of	IN
cord-048466-fj9l8che	1	23	human	human	JJ
cord-048466-fj9l8che	1	24	influenza	influenza	NN
cord-048466-fj9l8che	1	25	A	a	DT
cord-048466-fj9l8che	1	26	viruses	virus	NNS
cord-048466-fj9l8che	1	27	from	from	IN
cord-048466-fj9l8che	1	28	1999	1999	CD
cord-048466-fj9l8che	1	29	to	to	IN
cord-048466-fj9l8che	1	30	2006	2006	CD
cord-048466-fj9l8che	1	31	:	:	:
cord-048466-fj9l8che	1	32	A	a	DT
cord-048466-fj9l8che	1	33	complete	complete	JJ
cord-048466-fj9l8che	1	34	genome	genome	NN
cord-048466-fj9l8che	1	35	study	study	NN
cord-048466-fj9l8che	1	36	date	date	NN
cord-048466-fj9l8che	1	37	:	:	:
cord-048466-fj9l8che	1	38	2008	2008	CD
cord-048466-fj9l8che	1	39	-	-	SYM
cord-048466-fj9l8che	1	40	03	03	CD
cord-048466-fj9l8che	1	41	-	-	HYPH
cord-048466-fj9l8che	1	42	07	07	CD
cord-048466-fj9l8che	1	43	journal	journal	NN
cord-048466-fj9l8che	1	44	:	:	:
cord-048466-fj9l8che	2	1	Virol	Virol	NNP
cord-048466-fj9l8che	2	2	J	J	NNP
cord-048466-fj9l8che	2	3	DOI	DOI	NNP
cord-048466-fj9l8che	2	4	:	:	:
cord-048466-fj9l8che	2	5	10.1186/1743	10.1186/1743	CD
cord-048466-fj9l8che	2	6	-	-	HYPH
cord-048466-fj9l8che	2	7	422x-5	422x-5	CD
cord-048466-fj9l8che	2	8	-	-	HYPH
cord-048466-fj9l8che	2	9	40	40	CD
cord-048466-fj9l8che	3	1	sha	sha	NNP
cord-048466-fj9l8che	3	2	:	:	:
cord-048466-fj9l8che	4	1	94f84033171f0a095afc62fa7f44a597e6508a72	94f84033171f0a095afc62fa7f44a597e6508a72	NNP
cord-048466-fj9l8che	4	2	doc_id	doc_id	CD
cord-048466-fj9l8che	4	3	:	:	:
cord-048466-fj9l8che	4	4	48466	48466	CD
cord-048466-fj9l8che	4	5	cord_uid	cord_uid	NNS
cord-048466-fj9l8che	4	6	:	:	:
cord-048466-fj9l8che	4	7	fj9l8che	fj9l8che	IN
cord-048466-fj9l8che	4	8	BACKGROUND	background	NN
cord-048466-fj9l8che	4	9	:	:	:
cord-048466-fj9l8che	5	1	Knowledge	knowledge	NN
cord-048466-fj9l8che	5	2	about	about	IN
cord-048466-fj9l8che	5	3	the	the	DT
cord-048466-fj9l8che	5	4	complete	complete	JJ
cord-048466-fj9l8che	5	5	genome	genome	NN
cord-048466-fj9l8che	5	6	constellation	constellation	NN
cord-048466-fj9l8che	5	7	of	of	IN
cord-048466-fj9l8che	5	8	seasonal	seasonal	JJ
cord-048466-fj9l8che	5	9	influenza	influenza	NN
cord-048466-fj9l8che	5	10	A	a	DT
cord-048466-fj9l8che	5	11	viruses	virus	NNS
cord-048466-fj9l8che	5	12	from	from	IN
cord-048466-fj9l8che	5	13	different	different	JJ
cord-048466-fj9l8che	5	14	countries	country	NNS
cord-048466-fj9l8che	5	15	is	be	VBZ
cord-048466-fj9l8che	5	16	valuable	valuable	JJ
cord-048466-fj9l8che	5	17	for	for	IN
cord-048466-fj9l8che	5	18	monitoring	monitoring	NN
cord-048466-fj9l8che	5	19	and	and	CC
cord-048466-fj9l8che	5	20	understanding	understanding	NN
cord-048466-fj9l8che	5	21	of	of	IN
cord-048466-fj9l8che	5	22	the	the	DT
cord-048466-fj9l8che	5	23	evolution	evolution	NN
cord-048466-fj9l8che	5	24	and	and	CC
cord-048466-fj9l8che	5	25	migration	migration	NN
cord-048466-fj9l8che	5	26	of	of	IN
cord-048466-fj9l8che	5	27	strains	strain	NNS
cord-048466-fj9l8che	5	28	.	.	.
cord-048466-fj9l8che	6	1	Few	few	JJ
cord-048466-fj9l8che	6	2	complete	complete	JJ
cord-048466-fj9l8che	6	3	genome	genome	NN
cord-048466-fj9l8che	6	4	sequences	sequence	NNS
cord-048466-fj9l8che	6	5	of	of	IN
cord-048466-fj9l8che	6	6	influenza	influenza	NN
cord-048466-fj9l8che	6	7	A	a	DT
cord-048466-fj9l8che	6	8	viruses	virus	NNS
cord-048466-fj9l8che	6	9	from	from	IN
cord-048466-fj9l8che	6	10	Europe	Europe	NNP
cord-048466-fj9l8che	6	11	are	be	VBP
cord-048466-fj9l8che	6	12	publicly	publicly	RB
cord-048466-fj9l8che	6	13	available	available	JJ
cord-048466-fj9l8che	6	14	at	at	IN
cord-048466-fj9l8che	6	15	the	the	DT
cord-048466-fj9l8che	6	16	present	present	JJ
cord-048466-fj9l8che	6	17	time	time	NN
cord-048466-fj9l8che	6	18	and	and	CC
cord-048466-fj9l8che	6	19	there	there	EX
cord-048466-fj9l8che	6	20	have	have	VBP
cord-048466-fj9l8che	6	21	been	be	VBN
cord-048466-fj9l8che	6	22	few	few	JJ
cord-048466-fj9l8che	6	23	longitudinal	longitudinal	JJ
cord-048466-fj9l8che	6	24	genome	genome	NN
cord-048466-fj9l8che	6	25	studies	study	NNS
cord-048466-fj9l8che	6	26	of	of	IN
cord-048466-fj9l8che	6	27	human	human	JJ
cord-048466-fj9l8che	6	28	influenza	influenza	NN
cord-048466-fj9l8che	6	29	A	a	DT
cord-048466-fj9l8che	6	30	viruses	virus	NNS
cord-048466-fj9l8che	6	31	.	.	.
cord-048466-fj9l8che	7	1	We	-PRON-	PRP
cord-048466-fj9l8che	7	2	have	have	VBP
cord-048466-fj9l8che	7	3	studied	study	VBN
cord-048466-fj9l8che	7	4	the	the	DT
cord-048466-fj9l8che	7	5	evolution	evolution	NN
cord-048466-fj9l8che	7	6	of	of	IN
cord-048466-fj9l8che	7	7	circulating	circulate	VBG
cord-048466-fj9l8che	7	8	human	human	JJ
cord-048466-fj9l8che	7	9	H3N2	H3N2	NNP
cord-048466-fj9l8che	7	10	,	,	,
cord-048466-fj9l8che	7	11	H1N1	H1N1	NNP
cord-048466-fj9l8che	7	12	and	and	CC
cord-048466-fj9l8che	7	13	H1N2	H1N2	NNP
cord-048466-fj9l8che	7	14	influenza	influenza	NN
cord-048466-fj9l8che	7	15	A	a	DT
cord-048466-fj9l8che	7	16	viruses	virus	NNS
cord-048466-fj9l8che	7	17	from	from	IN
cord-048466-fj9l8che	7	18	1999	1999	CD
cord-048466-fj9l8che	7	19	to	to	IN
cord-048466-fj9l8che	7	20	2006	2006	CD
cord-048466-fj9l8che	7	21	,	,	,
cord-048466-fj9l8che	7	22	we	-PRON-	PRP
cord-048466-fj9l8che	7	23	analysed	analyse	VBD
cord-048466-fj9l8che	7	24	234	234	CD
cord-048466-fj9l8che	7	25	Danish	danish	JJ
cord-048466-fj9l8che	7	26	human	human	JJ
cord-048466-fj9l8che	7	27	influenza	influenza	NN
cord-048466-fj9l8che	7	28	A	a	DT
cord-048466-fj9l8che	7	29	viruses	virus	NNS
cord-048466-fj9l8che	7	30	and	and	CC
cord-048466-fj9l8che	7	31	characterised	characterise	VBD
cord-048466-fj9l8che	7	32	24	24	CD
cord-048466-fj9l8che	7	33	complete	complete	JJ
cord-048466-fj9l8che	7	34	genomes	genome	NNS
cord-048466-fj9l8che	7	35	.	.	.
cord-048466-fj9l8che	8	1	RESULTS	result	NNS
cord-048466-fj9l8che	8	2	:	:	:
cord-048466-fj9l8che	9	1	H3N2	H3N2	NNP
cord-048466-fj9l8che	9	2	was	be	VBD
cord-048466-fj9l8che	9	3	the	the	DT
cord-048466-fj9l8che	9	4	prevalent	prevalent	JJ
cord-048466-fj9l8che	9	5	strain	strain	NN
cord-048466-fj9l8che	9	6	in	in	IN
cord-048466-fj9l8che	9	7	Denmark	Denmark	NNP
cord-048466-fj9l8che	9	8	during	during	IN
cord-048466-fj9l8che	9	9	the	the	DT
cord-048466-fj9l8che	9	10	study	study	NN
cord-048466-fj9l8che	9	11	period	period	NN
cord-048466-fj9l8che	9	12	,	,	,
cord-048466-fj9l8che	9	13	but	but	CC
cord-048466-fj9l8che	9	14	H1N1	H1N1	NNP
cord-048466-fj9l8che	9	15	dominated	dominate	VBD
cord-048466-fj9l8che	9	16	the	the	DT
cord-048466-fj9l8che	9	17	2000–2001	2000–2001	CD
cord-048466-fj9l8che	9	18	season	season	NN
cord-048466-fj9l8che	9	19	.	.	.
cord-048466-fj9l8che	10	1	H1N2	H1N2	NNP
cord-048466-fj9l8che	10	2	viruses	virus	NNS
cord-048466-fj9l8che	10	3	were	be	VBD
cord-048466-fj9l8che	10	4	first	first	RB
cord-048466-fj9l8che	10	5	observed	observe	VBN
cord-048466-fj9l8che	10	6	in	in	IN
cord-048466-fj9l8che	10	7	Denmark	Denmark	NNP
cord-048466-fj9l8che	10	8	in	in	IN
cord-048466-fj9l8che	10	9	2002–2003	2002–2003	CD
cord-048466-fj9l8che	10	10	.	.	.
cord-048466-fj9l8che	11	1	After	after	IN
cord-048466-fj9l8che	11	2	years	year	NNS
cord-048466-fj9l8che	11	3	of	of	IN
cord-048466-fj9l8che	11	4	little	little	JJ
cord-048466-fj9l8che	11	5	genetic	genetic	JJ
cord-048466-fj9l8che	11	6	change	change	NN
cord-048466-fj9l8che	11	7	in	in	IN
cord-048466-fj9l8che	11	8	the	the	DT
cord-048466-fj9l8che	11	9	H1N1	H1N1	NNP
cord-048466-fj9l8che	11	10	viruses	viruse	VBZ
cord-048466-fj9l8che	11	11	the	the	DT
cord-048466-fj9l8che	11	12	2005–2006	2005–2006	CD
cord-048466-fj9l8che	11	13	season	season	NN
cord-048466-fj9l8che	11	14	presented	present	VBD
cord-048466-fj9l8che	11	15	H1N1	H1N1	NNP
cord-048466-fj9l8che	11	16	of	of	IN
cord-048466-fj9l8che	11	17	greater	great	JJR
cord-048466-fj9l8che	11	18	variability	variability	NN
cord-048466-fj9l8che	11	19	than	than	IN
cord-048466-fj9l8che	11	20	before	before	RB
cord-048466-fj9l8che	11	21	.	.	.
cord-048466-fj9l8che	12	1	This	this	DT
cord-048466-fj9l8che	12	2	indicates	indicate	VBZ
cord-048466-fj9l8che	12	3	that	that	IN
cord-048466-fj9l8che	12	4	H1N1	H1N1	NNP
cord-048466-fj9l8che	12	5	viruses	virus	NNS
cord-048466-fj9l8che	12	6	are	be	VBP
cord-048466-fj9l8che	12	7	evolving	evolve	VBG
cord-048466-fj9l8che	12	8	and	and	CC
cord-048466-fj9l8che	12	9	that	that	IN
cord-048466-fj9l8che	12	10	H1N1	H1N1	NNP
cord-048466-fj9l8che	12	11	soon	soon	RB
cord-048466-fj9l8che	12	12	is	be	VBZ
cord-048466-fj9l8che	12	13	likely	likely	JJ
cord-048466-fj9l8che	12	14	to	to	TO
cord-048466-fj9l8che	12	15	be	be	VB
cord-048466-fj9l8che	12	16	the	the	DT
cord-048466-fj9l8che	12	17	prevalent	prevalent	JJ
cord-048466-fj9l8che	12	18	strain	strain	NN
cord-048466-fj9l8che	12	19	again	again	RB
cord-048466-fj9l8che	12	20	.	.	.
cord-048466-fj9l8che	13	1	Generally	generally	RB
cord-048466-fj9l8che	13	2	,	,	,
cord-048466-fj9l8che	13	3	the	the	DT
cord-048466-fj9l8che	13	4	influenza	influenza	NN
cord-048466-fj9l8che	13	5	A	a	DT
cord-048466-fj9l8che	13	6	haemagglutinin	haemagglutinin	NN
cord-048466-fj9l8che	13	7	(	(	-LRB-
cord-048466-fj9l8che	13	8	HA	HA	NNP
cord-048466-fj9l8che	13	9	)	)	-RRB-
cord-048466-fj9l8che	13	10	of	of	IN
cord-048466-fj9l8che	13	11	H3N2	H3N2	NNP
cord-048466-fj9l8che	13	12	viruses	virus	NNS
cord-048466-fj9l8che	13	13	formed	form	VBD
cord-048466-fj9l8che	13	14	seasonal	seasonal	JJ
cord-048466-fj9l8che	13	15	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	13	16	clusters	cluster	NNS
cord-048466-fj9l8che	13	17	.	.	.
cord-048466-fj9l8che	14	1	Different	different	JJ
cord-048466-fj9l8che	14	2	lineages	lineage	NNS
cord-048466-fj9l8che	14	3	co	co	VBP
cord-048466-fj9l8che	14	4	-	-	NN
cord-048466-fj9l8che	14	5	circulating	circulating	NN
cord-048466-fj9l8che	14	6	within	within	IN
cord-048466-fj9l8che	14	7	the	the	DT
cord-048466-fj9l8che	14	8	same	same	JJ
cord-048466-fj9l8che	14	9	season	season	NN
cord-048466-fj9l8che	14	10	were	be	VBD
cord-048466-fj9l8che	14	11	also	also	RB
cord-048466-fj9l8che	14	12	observed	observe	VBN
cord-048466-fj9l8che	14	13	.	.	.
cord-048466-fj9l8che	15	1	The	the	DT
cord-048466-fj9l8che	15	2	evolution	evolution	NN
cord-048466-fj9l8che	15	3	has	have	VBZ
cord-048466-fj9l8che	15	4	been	be	VBN
cord-048466-fj9l8che	15	5	stochastic	stochastic	JJ
cord-048466-fj9l8che	15	6	,	,	,
cord-048466-fj9l8che	15	7	influenced	influence	VBN
cord-048466-fj9l8che	15	8	by	by	IN
cord-048466-fj9l8che	15	9	small	small	JJ
cord-048466-fj9l8che	15	10	"	"	``
cord-048466-fj9l8che	15	11	jumps	jump	NNS
cord-048466-fj9l8che	15	12	"	"	''
cord-048466-fj9l8che	15	13	in	in	IN
cord-048466-fj9l8che	15	14	genetic	genetic	JJ
cord-048466-fj9l8che	15	15	distance	distance	NN
cord-048466-fj9l8che	15	16	rather	rather	RB
cord-048466-fj9l8che	15	17	than	than	IN
cord-048466-fj9l8che	15	18	constant	constant	JJ
cord-048466-fj9l8che	15	19	drift	drift	NN
cord-048466-fj9l8che	15	20	,	,	,
cord-048466-fj9l8che	15	21	especially	especially	RB
cord-048466-fj9l8che	15	22	with	with	IN
cord-048466-fj9l8che	15	23	the	the	DT
cord-048466-fj9l8che	15	24	introduction	introduction	NN
cord-048466-fj9l8che	15	25	of	of	IN
cord-048466-fj9l8che	15	26	the	the	DT
cord-048466-fj9l8che	15	27	Fujian	Fujian	NNP
cord-048466-fj9l8che	15	28	-	-	HYPH
cord-048466-fj9l8che	15	29	like	like	JJ
cord-048466-fj9l8che	15	30	viruses	virus	NNS
cord-048466-fj9l8che	15	31	in	in	IN
cord-048466-fj9l8che	15	32	2002–2003	2002–2003	CD
cord-048466-fj9l8che	15	33	.	.	.
cord-048466-fj9l8che	16	1	Also	also	RB
cord-048466-fj9l8che	16	2	evolutionary	evolutionary	JJ
cord-048466-fj9l8che	16	3	stasis	stasis	NN
cord-048466-fj9l8che	16	4	-	-	HYPH
cord-048466-fj9l8che	16	5	periods	period	NNS
cord-048466-fj9l8che	16	6	were	be	VBD
cord-048466-fj9l8che	16	7	observed	observe	VBN
cord-048466-fj9l8che	16	8	which	which	WDT
cord-048466-fj9l8che	16	9	might	may	MD
cord-048466-fj9l8che	16	10	indicate	indicate	VB
cord-048466-fj9l8che	16	11	well	well	RB
cord-048466-fj9l8che	16	12	fit	fit	JJ
cord-048466-fj9l8che	16	13	viruses	virus	NNS
cord-048466-fj9l8che	16	14	.	.	.
cord-048466-fj9l8che	17	1	The	the	DT
cord-048466-fj9l8che	17	2	evolution	evolution	NN
cord-048466-fj9l8che	17	3	of	of	IN
cord-048466-fj9l8che	17	4	H3N2	H3N2	NNP
cord-048466-fj9l8che	17	5	viruses	virus	NNS
cord-048466-fj9l8che	17	6	have	have	VBP
cord-048466-fj9l8che	17	7	also	also	RB
cord-048466-fj9l8che	17	8	been	be	VBN
cord-048466-fj9l8che	17	9	influenced	influence	VBN
cord-048466-fj9l8che	17	10	by	by	IN
cord-048466-fj9l8che	17	11	gene	gene	NN
cord-048466-fj9l8che	17	12	reassortments	reassortment	NNS
cord-048466-fj9l8che	17	13	between	between	IN
cord-048466-fj9l8che	17	14	lineages	lineage	NNS
cord-048466-fj9l8che	17	15	from	from	IN
cord-048466-fj9l8che	17	16	different	different	JJ
cord-048466-fj9l8che	17	17	seasons	season	NNS
cord-048466-fj9l8che	17	18	.	.	.
cord-048466-fj9l8che	18	1	None	none	NN
cord-048466-fj9l8che	18	2	of	of	IN
cord-048466-fj9l8che	18	3	the	the	DT
cord-048466-fj9l8che	18	4	influenza	influenza	NN
cord-048466-fj9l8che	18	5	genes	gene	NNS
cord-048466-fj9l8che	18	6	were	be	VBD
cord-048466-fj9l8che	18	7	influenced	influence	VBN
cord-048466-fj9l8che	18	8	by	by	IN
cord-048466-fj9l8che	18	9	strong	strong	JJ
cord-048466-fj9l8che	18	10	positive	positive	JJ
cord-048466-fj9l8che	18	11	selection	selection	NN
cord-048466-fj9l8che	18	12	pressure	pressure	NN
cord-048466-fj9l8che	18	13	.	.	.
cord-048466-fj9l8che	19	1	The	the	DT
cord-048466-fj9l8che	19	2	antigenic	antigenic	JJ
cord-048466-fj9l8che	19	3	site	site	NN
cord-048466-fj9l8che	19	4	B	b	NN
cord-048466-fj9l8che	19	5	in	in	IN
cord-048466-fj9l8che	19	6	H3N2	H3N2	NNP
cord-048466-fj9l8che	19	7	HA	HA	NNP
cord-048466-fj9l8che	19	8	was	be	VBD
cord-048466-fj9l8che	19	9	the	the	DT
cord-048466-fj9l8che	19	10	preferred	preferred	JJ
cord-048466-fj9l8che	19	11	site	site	NN
cord-048466-fj9l8che	19	12	for	for	IN
cord-048466-fj9l8che	19	13	genetic	genetic	JJ
cord-048466-fj9l8che	19	14	change	change	NN
cord-048466-fj9l8che	19	15	during	during	IN
cord-048466-fj9l8che	19	16	the	the	DT
cord-048466-fj9l8che	19	17	study	study	NN
cord-048466-fj9l8che	19	18	period	period	NN
cord-048466-fj9l8che	19	19	probably	probably	RB
cord-048466-fj9l8che	19	20	because	because	IN
cord-048466-fj9l8che	19	21	the	the	DT
cord-048466-fj9l8che	19	22	site	site	NN
cord-048466-fj9l8che	19	23	A	a	NN
cord-048466-fj9l8che	19	24	has	have	VBZ
cord-048466-fj9l8che	19	25	been	be	VBN
cord-048466-fj9l8che	19	26	masked	mask	VBN
cord-048466-fj9l8che	19	27	by	by	IN
cord-048466-fj9l8che	19	28	glycosylations	glycosylation	NNS
cord-048466-fj9l8che	19	29	.	.	.
cord-048466-fj9l8che	20	1	Substitutions	substitution	NNS
cord-048466-fj9l8che	20	2	at	at	IN
cord-048466-fj9l8che	20	3	CTL	CTL	NNP
cord-048466-fj9l8che	20	4	-	-	HYPH
cord-048466-fj9l8che	20	5	epitopes	epitope	NNS
cord-048466-fj9l8che	20	6	in	in	IN
cord-048466-fj9l8che	20	7	the	the	DT
cord-048466-fj9l8che	20	8	genes	gene	NNS
cord-048466-fj9l8che	20	9	coding	code	VBG
cord-048466-fj9l8che	20	10	for	for	IN
cord-048466-fj9l8che	20	11	the	the	DT
cord-048466-fj9l8che	20	12	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	20	13	(	(	-LRB-
cord-048466-fj9l8che	20	14	NA	NA	NNP
cord-048466-fj9l8che	20	15	)	)	-RRB-
cord-048466-fj9l8che	20	16	,	,	,
cord-048466-fj9l8che	20	17	polymerase	polymerase	VBP
cord-048466-fj9l8che	20	18	acidic	acidic	JJ
cord-048466-fj9l8che	20	19	protein	protein	NN
cord-048466-fj9l8che	20	20	(	(	-LRB-
cord-048466-fj9l8che	20	21	PA	PA	NNP
cord-048466-fj9l8che	20	22	)	)	-RRB-
cord-048466-fj9l8che	20	23	,	,	,
cord-048466-fj9l8che	20	24	matrix	matrix	NN
cord-048466-fj9l8che	20	25	protein	protein	NN
cord-048466-fj9l8che	20	26	1	1	CD
cord-048466-fj9l8che	20	27	(	(	-LRB-
cord-048466-fj9l8che	20	28	M1	M1	NNP
cord-048466-fj9l8che	20	29	)	)	-RRB-
cord-048466-fj9l8che	20	30	,	,	,
cord-048466-fj9l8che	20	31	non	non	JJ
cord-048466-fj9l8che	20	32	-	-	JJ
cord-048466-fj9l8che	20	33	structural	structural	JJ
cord-048466-fj9l8che	20	34	protein	protein	NN
cord-048466-fj9l8che	20	35	1	1	CD
cord-048466-fj9l8che	20	36	(	(	-LRB-
cord-048466-fj9l8che	20	37	NS1	ns1	NN
cord-048466-fj9l8che	20	38	)	)	-RRB-
cord-048466-fj9l8che	20	39	and	and	CC
cord-048466-fj9l8che	20	40	especially	especially	RB
cord-048466-fj9l8che	20	41	the	the	DT
cord-048466-fj9l8che	20	42	nucleoprotein	nucleoprotein	NNP
cord-048466-fj9l8che	20	43	(	(	-LRB-
cord-048466-fj9l8che	20	44	NP	NP	NNP
cord-048466-fj9l8che	20	45	)	)	-RRB-
cord-048466-fj9l8che	20	46	were	be	VBD
cord-048466-fj9l8che	20	47	observed	observe	VBN
cord-048466-fj9l8che	20	48	.	.	.
cord-048466-fj9l8che	21	1	The	the	DT
cord-048466-fj9l8che	21	2	N	N	NNP
cord-048466-fj9l8che	21	3	-	-	HYPH
cord-048466-fj9l8che	21	4	linked	link	VBN
cord-048466-fj9l8che	21	5	glycosylation	glycosylation	NN
cord-048466-fj9l8che	21	6	pattern	pattern	NN
cord-048466-fj9l8che	21	7	varied	vary	VBN
cord-048466-fj9l8che	21	8	during	during	IN
cord-048466-fj9l8che	21	9	the	the	DT
cord-048466-fj9l8che	21	10	study	study	NN
cord-048466-fj9l8che	21	11	period	period	NN
cord-048466-fj9l8che	21	12	and	and	CC
cord-048466-fj9l8che	21	13	the	the	DT
cord-048466-fj9l8che	21	14	H3N2	H3N2	NNP
cord-048466-fj9l8che	21	15	isolates	isolate	VBZ
cord-048466-fj9l8che	21	16	from	from	IN
cord-048466-fj9l8che	21	17	2004	2004	CD
cord-048466-fj9l8che	21	18	to	to	IN
cord-048466-fj9l8che	21	19	2006	2006	CD
cord-048466-fj9l8che	21	20	were	be	VBD
cord-048466-fj9l8che	21	21	highly	highly	RB
cord-048466-fj9l8che	21	22	glycosylated	glycosylate	VBN
cord-048466-fj9l8che	21	23	with	with	IN
cord-048466-fj9l8che	21	24	ten	ten	CD
cord-048466-fj9l8che	21	25	predicted	predict	VBN
cord-048466-fj9l8che	21	26	sequons	sequon	NNS
cord-048466-fj9l8che	21	27	in	in	IN
cord-048466-fj9l8che	21	28	HA	HA	NNP
cord-048466-fj9l8che	21	29	,	,	,
cord-048466-fj9l8che	21	30	the	the	DT
cord-048466-fj9l8che	21	31	highest	high	JJS
cord-048466-fj9l8che	21	32	amount	amount	NN
cord-048466-fj9l8che	21	33	of	of	IN
cord-048466-fj9l8che	21	34	glycosylations	glycosylation	NNS
cord-048466-fj9l8che	21	35	observed	observe	VBN
cord-048466-fj9l8che	21	36	in	in	IN
cord-048466-fj9l8che	21	37	this	this	DT
cord-048466-fj9l8che	21	38	study	study	NN
cord-048466-fj9l8che	21	39	period	period	NN
cord-048466-fj9l8che	21	40	.	.	.
cord-048466-fj9l8che	22	1	CONCLUSION	conclusion	NN
cord-048466-fj9l8che	22	2	:	:	:
cord-048466-fj9l8che	23	1	The	the	DT
cord-048466-fj9l8che	23	2	present	present	JJ
cord-048466-fj9l8che	23	3	study	study	NN
cord-048466-fj9l8che	23	4	is	be	VBZ
cord-048466-fj9l8che	23	5	the	the	DT
cord-048466-fj9l8che	23	6	first	first	JJ
cord-048466-fj9l8che	23	7	to	to	IN
cord-048466-fj9l8che	23	8	our	-PRON-	PRP$
cord-048466-fj9l8che	23	9	knowledge	knowledge	NN
cord-048466-fj9l8che	23	10	to	to	TO
cord-048466-fj9l8che	23	11	characterise	characterise	VB
cord-048466-fj9l8che	23	12	the	the	DT
cord-048466-fj9l8che	23	13	evolution	evolution	NN
cord-048466-fj9l8che	23	14	of	of	IN
cord-048466-fj9l8che	23	15	complete	complete	JJ
cord-048466-fj9l8che	23	16	genomes	genome	NNS
cord-048466-fj9l8che	23	17	of	of	IN
cord-048466-fj9l8che	23	18	influenza	influenza	NN
cord-048466-fj9l8che	23	19	A	a	DT
cord-048466-fj9l8che	23	20	H3N2	H3N2	NNP
cord-048466-fj9l8che	23	21	,	,	,
cord-048466-fj9l8che	23	22	H1N1	H1N1	NNP
cord-048466-fj9l8che	23	23	and	and	CC
cord-048466-fj9l8che	23	24	H1N2	H1N2	NNP
cord-048466-fj9l8che	23	25	isolates	isolate	VBZ
cord-048466-fj9l8che	23	26	from	from	IN
cord-048466-fj9l8che	23	27	Europe	Europe	NNP
cord-048466-fj9l8che	23	28	over	over	IN
cord-048466-fj9l8che	23	29	a	a	DT
cord-048466-fj9l8che	23	30	time	time	NN
cord-048466-fj9l8che	23	31	period	period	NN
cord-048466-fj9l8che	23	32	of	of	IN
cord-048466-fj9l8che	23	33	seven	seven	CD
cord-048466-fj9l8che	23	34	years	year	NNS
cord-048466-fj9l8che	23	35	from	from	IN
cord-048466-fj9l8che	23	36	1999	1999	CD
cord-048466-fj9l8che	23	37	to	to	IN
cord-048466-fj9l8che	23	38	2006	2006	CD
cord-048466-fj9l8che	23	39	.	.	.
cord-048466-fj9l8che	24	1	More	more	RBR
cord-048466-fj9l8che	24	2	precise	precise	JJ
cord-048466-fj9l8che	24	3	knowledge	knowledge	NN
cord-048466-fj9l8che	24	4	about	about	IN
cord-048466-fj9l8che	24	5	the	the	DT
cord-048466-fj9l8che	24	6	circulating	circulate	VBG
cord-048466-fj9l8che	24	7	strains	strain	NNS
cord-048466-fj9l8che	24	8	may	may	MD
cord-048466-fj9l8che	24	9	have	have	VB
cord-048466-fj9l8che	24	10	implications	implication	NNS
cord-048466-fj9l8che	24	11	for	for	IN
cord-048466-fj9l8che	24	12	predicting	predict	VBG
cord-048466-fj9l8che	24	13	the	the	DT
cord-048466-fj9l8che	24	14	following	following	JJ
cord-048466-fj9l8che	24	15	season	season	NN
cord-048466-fj9l8che	24	16	strains	strain	NNS
cord-048466-fj9l8che	24	17	and	and	CC
cord-048466-fj9l8che	24	18	thereby	thereby	RB
cord-048466-fj9l8che	24	19	better	well	RBR
cord-048466-fj9l8che	24	20	matching	match	VBG
cord-048466-fj9l8che	24	21	the	the	DT
cord-048466-fj9l8che	24	22	vaccine	vaccine	NN
cord-048466-fj9l8che	24	23	composition	composition	NN
cord-048466-fj9l8che	24	24	.	.	.
cord-048466-fj9l8che	25	1	Every	every	DT
cord-048466-fj9l8che	25	2	year	year	NN
cord-048466-fj9l8che	25	3	the	the	DT
cord-048466-fj9l8che	25	4	influenza	influenza	NN
cord-048466-fj9l8che	25	5	A	a	DT
cord-048466-fj9l8che	25	6	virus	virus	NN
cord-048466-fj9l8che	25	7	causes	cause	VBZ
cord-048466-fj9l8che	25	8	human	human	JJ
cord-048466-fj9l8che	25	9	infection	infection	NN
cord-048466-fj9l8che	25	10	with	with	IN
cord-048466-fj9l8che	25	11	varying	vary	VBG
cord-048466-fj9l8che	25	12	severity	severity	NN
cord-048466-fj9l8che	25	13	depending	depend	VBG
cord-048466-fj9l8che	25	14	on	on	IN
cord-048466-fj9l8che	25	15	the	the	DT
cord-048466-fj9l8che	25	16	host	host	NN
cord-048466-fj9l8che	25	17	acquired	acquire	VBD
cord-048466-fj9l8che	25	18	immunity	immunity	NN
cord-048466-fj9l8che	25	19	against	against	IN
cord-048466-fj9l8che	25	20	the	the	DT
cord-048466-fj9l8che	25	21	particular	particular	JJ
cord-048466-fj9l8che	25	22	virus	virus	NN
cord-048466-fj9l8che	25	23	strain	strain	NN
cord-048466-fj9l8che	25	24	.	.	.
cord-048466-fj9l8che	26	1	Three	three	CD
cord-048466-fj9l8che	26	2	to	to	TO
cord-048466-fj9l8che	26	3	five	five	CD
cord-048466-fj9l8che	26	4	million	million	CD
cord-048466-fj9l8che	26	5	people	people	NNS
cord-048466-fj9l8che	26	6	experience	experience	VBP
cord-048466-fj9l8che	26	7	severe	severe	JJ
cord-048466-fj9l8che	26	8	illness	illness	NN
cord-048466-fj9l8che	26	9	and	and	CC
cord-048466-fj9l8che	26	10	0.25	0.25	CD
cord-048466-fj9l8che	26	11	to	to	IN
cord-048466-fj9l8che	26	12	0.5	0.5	CD
cord-048466-fj9l8che	26	13	million	million	CD
cord-048466-fj9l8che	26	14	people	people	NNS
cord-048466-fj9l8che	26	15	die	die	VBP
cord-048466-fj9l8che	26	16	of	of	IN
cord-048466-fj9l8che	26	17	influenza	influenza	NN
cord-048466-fj9l8che	26	18	yearly	yearly	JJ
cord-048466-fj9l8che	26	19	worldwide	worldwide	RB
cord-048466-fj9l8che	26	20	(	(	-LRB-
cord-048466-fj9l8che	26	21	WHO	who	WP
cord-048466-fj9l8che	26	22	EB111/10	EB111/10	NNP
cord-048466-fj9l8che	26	23	)	)	-RRB-
cord-048466-fj9l8che	26	24	.	.	.
cord-048466-fj9l8che	27	1	The	the	DT
cord-048466-fj9l8che	27	2	influenza	influenza	NN
cord-048466-fj9l8che	27	3	virus	virus	NN
cord-048466-fj9l8che	27	4	evades	evade	VBZ
cord-048466-fj9l8che	27	5	host	host	NN
cord-048466-fj9l8che	27	6	immunity	immunity	NN
cord-048466-fj9l8che	27	7	by	by	IN
cord-048466-fj9l8che	27	8	accumulation	accumulation	NN
cord-048466-fj9l8che	27	9	of	of	IN
cord-048466-fj9l8che	27	10	point	point	NN
cord-048466-fj9l8che	27	11	mutations	mutation	NNS
cord-048466-fj9l8che	27	12	(	(	-LRB-
cord-048466-fj9l8che	27	13	drift	drift	NN
cord-048466-fj9l8che	27	14	)	)	-RRB-
cord-048466-fj9l8che	27	15	in	in	IN
cord-048466-fj9l8che	27	16	the	the	DT
cord-048466-fj9l8che	27	17	major	major	JJ
cord-048466-fj9l8che	27	18	surface	surface	NN
cord-048466-fj9l8che	27	19	glycoproteins	glycoprotein	NNS
cord-048466-fj9l8che	27	20	,	,	,
cord-048466-fj9l8che	27	21	haemagglutinin	haemagglutinin	NNP
cord-048466-fj9l8che	27	22	(	(	-LRB-
cord-048466-fj9l8che	27	23	HA	HA	NNP
cord-048466-fj9l8che	27	24	)	)	-RRB-
cord-048466-fj9l8che	27	25	and	and	CC
cord-048466-fj9l8che	27	26	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	27	27	(	(	-LRB-
cord-048466-fj9l8che	27	28	NA	NA	NNP
cord-048466-fj9l8che	27	29	)	)	-RRB-
cord-048466-fj9l8che	27	30	or	or	CC
cord-048466-fj9l8che	27	31	by	by	IN
cord-048466-fj9l8che	27	32	reassortment	reassortment	NN
cord-048466-fj9l8che	27	33	of	of	IN
cord-048466-fj9l8che	27	34	segments	segment	NNS
cord-048466-fj9l8che	27	35	from	from	IN
cord-048466-fj9l8che	27	36	different	different	JJ
cord-048466-fj9l8che	27	37	viruses	virus	NNS
cord-048466-fj9l8che	27	38	co	co	VBD
cord-048466-fj9l8che	27	39	-	-	JJ
cord-048466-fj9l8che	27	40	infecting	infect	VBG
cord-048466-fj9l8che	27	41	the	the	DT
cord-048466-fj9l8che	27	42	same	same	JJ
cord-048466-fj9l8che	27	43	cell	cell	NN
cord-048466-fj9l8che	27	44	leading	lead	VBG
cord-048466-fj9l8che	27	45	to	to	IN
cord-048466-fj9l8che	27	46	a	a	DT
cord-048466-fj9l8che	27	47	new	new	JJ
cord-048466-fj9l8che	27	48	stain	stain	NN
cord-048466-fj9l8che	27	49	with	with	IN
cord-048466-fj9l8che	27	50	a	a	DT
cord-048466-fj9l8che	27	51	HA	HA	NNP
cord-048466-fj9l8che	27	52	(	(	-LRB-
cord-048466-fj9l8che	27	53	and	and	CC
cord-048466-fj9l8che	27	54	NA	NA	NNP
cord-048466-fj9l8che	27	55	)	)	-RRB-
cord-048466-fj9l8che	27	56	not	not	RB
cord-048466-fj9l8che	27	57	seen	see	VBN
cord-048466-fj9l8che	27	58	in	in	IN
cord-048466-fj9l8che	27	59	the	the	DT
cord-048466-fj9l8che	27	60	population	population	NN
cord-048466-fj9l8che	27	61	before	before	IN
cord-048466-fj9l8che	27	62	(	(	-LRB-
cord-048466-fj9l8che	27	63	shift	shift	NN
cord-048466-fj9l8che	27	64	)	)	-RRB-
cord-048466-fj9l8che	27	65	.	.	.
cord-048466-fj9l8che	28	1	In	in	IN
cord-048466-fj9l8che	28	2	the	the	DT
cord-048466-fj9l8che	28	3	worst	bad	JJS
cord-048466-fj9l8che	28	4	case	case	NN
cord-048466-fj9l8che	28	5	,	,	,
cord-048466-fj9l8che	28	6	shifts	shift	NNS
cord-048466-fj9l8che	28	7	may	may	MD
cord-048466-fj9l8che	28	8	cause	cause	VB
cord-048466-fj9l8che	28	9	pandemics	pandemic	NNS
cord-048466-fj9l8che	28	10	.	.	.
cord-048466-fj9l8che	29	1	There	there	EX
cord-048466-fj9l8che	29	2	have	have	VBP
cord-048466-fj9l8che	29	3	been	be	VBN
cord-048466-fj9l8che	29	4	three	three	CD
cord-048466-fj9l8che	29	5	pandemics	pandemic	NNS
cord-048466-fj9l8che	29	6	the	the	DT
cord-048466-fj9l8che	29	7	last	last	JJ
cord-048466-fj9l8che	29	8	hundred	hundred	CD
cord-048466-fj9l8che	29	9	years	year	NNS
cord-048466-fj9l8che	29	10	,	,	,
cord-048466-fj9l8che	29	11	the	the	DT
cord-048466-fj9l8che	29	12	Spanish	spanish	JJ
cord-048466-fj9l8che	29	13	flu	flu	NN
cord-048466-fj9l8che	29	14	in	in	IN
cord-048466-fj9l8che	29	15	1918	1918	CD
cord-048466-fj9l8che	29	16	(	(	-LRB-
cord-048466-fj9l8che	29	17	H1N1	H1N1	NNP
cord-048466-fj9l8che	29	18	)	)	-RRB-
cord-048466-fj9l8che	29	19	,	,	,
cord-048466-fj9l8che	29	20	the	the	DT
cord-048466-fj9l8che	29	21	Asian	asian	JJ
cord-048466-fj9l8che	29	22	flu	flu	NN
cord-048466-fj9l8che	29	23	in	in	IN
cord-048466-fj9l8che	29	24	1957	1957	CD
cord-048466-fj9l8che	29	25	(	(	-LRB-
cord-048466-fj9l8che	29	26	H2N2	H2N2	NNP
cord-048466-fj9l8che	29	27	)	)	-RRB-
cord-048466-fj9l8che	29	28	and	and	CC
cord-048466-fj9l8che	29	29	the	the	DT
cord-048466-fj9l8che	29	30	Hong	Hong	NNP
cord-048466-fj9l8che	29	31	Kong	Kong	NNP
cord-048466-fj9l8che	29	32	flu	flu	NN
cord-048466-fj9l8che	29	33	in	in	IN
cord-048466-fj9l8che	29	34	1968	1968	CD
cord-048466-fj9l8che	29	35	(	(	-LRB-
cord-048466-fj9l8che	29	36	H3N2	H3N2	NNP
cord-048466-fj9l8che	29	37	)	)	-RRB-
cord-048466-fj9l8che	29	38	.	.	.
cord-048466-fj9l8che	30	1	It	-PRON-	PRP
cord-048466-fj9l8che	30	2	is	be	VBZ
cord-048466-fj9l8che	30	3	believed	believe	VBN
cord-048466-fj9l8che	30	4	that	that	IN
cord-048466-fj9l8che	30	5	new	new	JJ
cord-048466-fj9l8che	30	6	pandemics	pandemic	NNS
cord-048466-fj9l8che	30	7	emerge	emerge	VBP
cord-048466-fj9l8che	30	8	through	through	IN
cord-048466-fj9l8che	30	9	shifts	shift	NNS
cord-048466-fj9l8che	30	10	with	with	IN
cord-048466-fj9l8che	30	11	strains	strain	NNS
cord-048466-fj9l8che	30	12	from	from	IN
cord-048466-fj9l8che	30	13	the	the	DT
cord-048466-fj9l8che	30	14	avian	avian	JJ
cord-048466-fj9l8che	30	15	reservoir	reservoir	NN
cord-048466-fj9l8che	30	16	,	,	,
cord-048466-fj9l8che	30	17	as	as	IN
cord-048466-fj9l8che	30	18	was	be	VBD
cord-048466-fj9l8che	30	19	the	the	DT
cord-048466-fj9l8che	30	20	case	case	NN
cord-048466-fj9l8che	30	21	of	of	IN
cord-048466-fj9l8che	30	22	the	the	DT
cord-048466-fj9l8che	30	23	pandemics	pandemic	NNS
cord-048466-fj9l8che	30	24	of	of	IN
cord-048466-fj9l8che	30	25	1957	1957	CD
cord-048466-fj9l8che	30	26	and	and	CC
cord-048466-fj9l8che	30	27	1968	1968	CD
cord-048466-fj9l8che	30	28	,	,	,
cord-048466-fj9l8che	30	29	or	or	CC
cord-048466-fj9l8che	30	30	by	by	IN
cord-048466-fj9l8che	30	31	direct	direct	JJ
cord-048466-fj9l8che	30	32	introduction	introduction	NN
cord-048466-fj9l8che	30	33	of	of	IN
cord-048466-fj9l8che	30	34	an	an	DT
cord-048466-fj9l8che	30	35	avian	avian	JJ
cord-048466-fj9l8che	30	36	strain	strain	NN
cord-048466-fj9l8che	30	37	into	into	IN
cord-048466-fj9l8che	30	38	the	the	DT
cord-048466-fj9l8che	30	39	human	human	JJ
cord-048466-fj9l8che	30	40	population	population	NN
cord-048466-fj9l8che	30	41	as	as	IN
cord-048466-fj9l8che	30	42	suggested	suggest	VBN
cord-048466-fj9l8che	30	43	for	for	IN
cord-048466-fj9l8che	30	44	the	the	DT
cord-048466-fj9l8che	30	45	1918	1918	CD
cord-048466-fj9l8che	30	46	pandemic	pandemic	NN
cord-048466-fj9l8che	30	47	[	[	-LRB-
cord-048466-fj9l8che	30	48	1	1	CD
cord-048466-fj9l8che	30	49	]	]	-RRB-
cord-048466-fj9l8che	30	50	.	.	.
cord-048466-fj9l8che	31	1	At	at	IN
cord-048466-fj9l8che	31	2	present	present	JJ
cord-048466-fj9l8che	31	3	only	only	RB
cord-048466-fj9l8che	31	4	two	two	CD
cord-048466-fj9l8che	31	5	of	of	IN
cord-048466-fj9l8che	31	6	the	the	DT
cord-048466-fj9l8che	31	7	16	16	CD
cord-048466-fj9l8che	31	8	possible	possible	JJ
cord-048466-fj9l8che	31	9	HA	HA	NNP
cord-048466-fj9l8che	31	10	subtypes	subtype	NNS
cord-048466-fj9l8che	31	11	(	(	-LRB-
cord-048466-fj9l8che	31	12	H1	H1	NNP
cord-048466-fj9l8che	31	13	and	and	CC
cord-048466-fj9l8che	31	14	H3	H3	NNP
cord-048466-fj9l8che	31	15	)	)	-RRB-
cord-048466-fj9l8che	31	16	,	,	,
cord-048466-fj9l8che	31	17	and	and	CC
cord-048466-fj9l8che	31	18	two	two	CD
cord-048466-fj9l8che	31	19	of	of	IN
cord-048466-fj9l8che	31	20	the	the	DT
cord-048466-fj9l8che	31	21	nine	nine	CD
cord-048466-fj9l8che	31	22	possible	possible	JJ
cord-048466-fj9l8che	31	23	NA	NA	NNP
cord-048466-fj9l8che	31	24	subtypes	subtype	NNS
cord-048466-fj9l8che	31	25	(	(	-LRB-
cord-048466-fj9l8che	31	26	N1	N1	NNP
cord-048466-fj9l8che	31	27	and	and	CC
cord-048466-fj9l8che	31	28	N2	N2	NNP
cord-048466-fj9l8che	31	29	)	)	-RRB-
cord-048466-fj9l8che	31	30	are	be	VBP
cord-048466-fj9l8che	31	31	circulating	circulate	VBG
cord-048466-fj9l8che	31	32	in	in	IN
cord-048466-fj9l8che	31	33	man	man	NN
cord-048466-fj9l8che	31	34	.	.	.
cord-048466-fj9l8che	32	1	H3N2	H3N2	NNP
cord-048466-fj9l8che	32	2	and	and	CC
cord-048466-fj9l8che	33	1	H1N1	H1N1	NNP
cord-048466-fj9l8che	33	2	influenza	influenza	NN
cord-048466-fj9l8che	33	3	A	a	DT
cord-048466-fj9l8che	33	4	viruses	virus	NNS
cord-048466-fj9l8che	33	5	have	have	VBP
cord-048466-fj9l8che	33	6	co	co	VBN
cord-048466-fj9l8che	33	7	-	-	VBN
cord-048466-fj9l8che	33	8	circulated	circulate	VBN
cord-048466-fj9l8che	33	9	in	in	IN
cord-048466-fj9l8che	33	10	the	the	DT
cord-048466-fj9l8che	33	11	human	human	JJ
cord-048466-fj9l8che	33	12	population	population	NN
cord-048466-fj9l8che	33	13	since	since	IN
cord-048466-fj9l8che	33	14	the	the	DT
cord-048466-fj9l8che	33	15	re	re	NN
cord-048466-fj9l8che	33	16	-	-	NN
cord-048466-fj9l8che	33	17	emergence	emergence	NN
cord-048466-fj9l8che	33	18	of	of	IN
cord-048466-fj9l8che	33	19	H1N1	H1N1	NNP
cord-048466-fj9l8che	33	20	in	in	IN
cord-048466-fj9l8che	33	21	1977	1977	CD
cord-048466-fj9l8che	33	22	,	,	,
cord-048466-fj9l8che	33	23	increasing	increase	VBG
cord-048466-fj9l8che	33	24	the	the	DT
cord-048466-fj9l8che	33	25	possibility	possibility	NN
cord-048466-fj9l8che	33	26	for	for	IN
cord-048466-fj9l8che	33	27	genetic	genetic	JJ
cord-048466-fj9l8che	33	28	reassortments	reassortment	NNS
cord-048466-fj9l8che	33	29	.	.	.
cord-048466-fj9l8che	34	1	The	the	DT
cord-048466-fj9l8che	34	2	prevalence	prevalence	NN
cord-048466-fj9l8che	34	3	of	of	IN
cord-048466-fj9l8che	34	4	the	the	DT
cord-048466-fj9l8che	34	5	different	different	JJ
cord-048466-fj9l8che	34	6	subtype	subtype	NN
cord-048466-fj9l8che	34	7	combinations	combination	NNS
cord-048466-fj9l8che	34	8	may	may	MD
cord-048466-fj9l8che	34	9	vary	vary	VB
cord-048466-fj9l8che	34	10	from	from	IN
cord-048466-fj9l8che	34	11	season	season	NN
cord-048466-fj9l8che	34	12	to	to	IN
cord-048466-fj9l8che	34	13	season	season	NN
cord-048466-fj9l8che	34	14	.	.	.
cord-048466-fj9l8che	35	1	The	the	DT
cord-048466-fj9l8che	35	2	H3N2	H3N2	NNP
cord-048466-fj9l8che	35	3	has	have	VBZ
cord-048466-fj9l8che	35	4	been	be	VBN
cord-048466-fj9l8che	35	5	the	the	DT
cord-048466-fj9l8che	35	6	predominant	predominant	JJ
cord-048466-fj9l8che	35	7	influenza	influenza	NN
cord-048466-fj9l8che	35	8	A	a	DT
cord-048466-fj9l8che	35	9	strain	strain	NN
cord-048466-fj9l8che	35	10	during	during	IN
cord-048466-fj9l8che	35	11	the	the	DT
cord-048466-fj9l8che	35	12	last	last	JJ
cord-048466-fj9l8che	35	13	20	20	CD
cord-048466-fj9l8che	35	14	years	year	NNS
cord-048466-fj9l8che	35	15	,	,	,
cord-048466-fj9l8che	35	16	with	with	IN
cord-048466-fj9l8che	35	17	the	the	DT
cord-048466-fj9l8che	35	18	exception	exception	NN
cord-048466-fj9l8che	35	19	of	of	IN
cord-048466-fj9l8che	35	20	the	the	DT
cord-048466-fj9l8che	35	21	1988	1988	CD
cord-048466-fj9l8che	35	22	-	-	SYM
cord-048466-fj9l8che	35	23	1989	1989	CD
cord-048466-fj9l8che	35	24	and	and	CC
cord-048466-fj9l8che	35	25	2000	2000	CD
cord-048466-fj9l8che	35	26	-	-	SYM
cord-048466-fj9l8che	35	27	2001	2001	CD
cord-048466-fj9l8che	35	28	seasons	season	NNS
cord-048466-fj9l8che	35	29	where	where	WRB
cord-048466-fj9l8che	35	30	H1N1	H1N1	NNP
cord-048466-fj9l8che	35	31	infections	infection	NNS
cord-048466-fj9l8che	35	32	dominated	dominate	VBD
cord-048466-fj9l8che	35	33	[	[	-LRB-
cord-048466-fj9l8che	35	34	2	2	CD
cord-048466-fj9l8che	35	35	]	]	-RRB-
cord-048466-fj9l8che	35	36	.	.	.
cord-048466-fj9l8che	36	1	In	in	IN
cord-048466-fj9l8che	36	2	the	the	DT
cord-048466-fj9l8che	36	3	2000	2000	CD
cord-048466-fj9l8che	36	4	-	-	SYM
cord-048466-fj9l8che	36	5	2001	2001	CD
cord-048466-fj9l8che	36	6	season	season	NN
cord-048466-fj9l8che	36	7	a	a	DT
cord-048466-fj9l8che	36	8	new	new	JJ
cord-048466-fj9l8che	36	9	reassorted	reassorte	VBN
cord-048466-fj9l8che	36	10	human	human	JJ
cord-048466-fj9l8che	36	11	strain	strain	NN
cord-048466-fj9l8che	36	12	,	,	,
cord-048466-fj9l8che	36	13	H1N2	H1N2	NNP
cord-048466-fj9l8che	36	14	,	,	,
cord-048466-fj9l8che	36	15	emerged	emerge	VBD
cord-048466-fj9l8che	36	16	in	in	IN
cord-048466-fj9l8che	36	17	Europe	Europe	NNP
cord-048466-fj9l8che	36	18	and	and	CC
cord-048466-fj9l8che	36	19	became	become	VBD
cord-048466-fj9l8che	36	20	established	establish	VBN
cord-048466-fj9l8che	36	21	in	in	IN
cord-048466-fj9l8che	36	22	the	the	DT
cord-048466-fj9l8che	36	23	autumn	autumn	NN
cord-048466-fj9l8che	36	24	2001	2001	CD
cord-048466-fj9l8che	36	25	[	[	-LRB-
cord-048466-fj9l8che	36	26	3	3	CD
cord-048466-fj9l8che	36	27	,	,	,
cord-048466-fj9l8che	36	28	4	4	CD
cord-048466-fj9l8che	36	29	]	]	-RRB-
cord-048466-fj9l8che	36	30	.	.	.
cord-048466-fj9l8che	37	1	The	the	DT
cord-048466-fj9l8che	37	2	new	new	JJ
cord-048466-fj9l8che	37	3	H1N2	H1N2	NNP
cord-048466-fj9l8che	37	4	subtype	subtype	NN
cord-048466-fj9l8che	37	5	was	be	VBD
cord-048466-fj9l8che	37	6	covered	cover	VBN
cord-048466-fj9l8che	37	7	by	by	IN
cord-048466-fj9l8che	37	8	the	the	DT
cord-048466-fj9l8che	37	9	2002	2002	CD
cord-048466-fj9l8che	37	10	-	-	SYM
cord-048466-fj9l8che	37	11	2003	2003	CD
cord-048466-fj9l8che	37	12	H1	H1	NNP
cord-048466-fj9l8che	37	13	and	and	CC
cord-048466-fj9l8che	37	14	N2	N2	NNP
cord-048466-fj9l8che	37	15	trivalent	trivalent	JJ
cord-048466-fj9l8che	37	16	vaccine	vaccine	NN
cord-048466-fj9l8che	37	17	components	component	NNS
cord-048466-fj9l8che	37	18	and	and	CC
cord-048466-fj9l8che	37	19	because	because	IN
cord-048466-fj9l8che	37	20	both	both	DT
cord-048466-fj9l8che	37	21	H1	H1	NNP
cord-048466-fj9l8che	37	22	and	and	CC
cord-048466-fj9l8che	37	23	N2	n2	NN
cord-048466-fj9l8che	37	24	viruses	virus	NNS
cord-048466-fj9l8che	37	25	had	have	VBD
cord-048466-fj9l8che	37	26	circulated	circulate	VBN
cord-048466-fj9l8che	37	27	the	the	DT
cord-048466-fj9l8che	37	28	previous	previous	JJ
cord-048466-fj9l8che	37	29	years	year	NNS
cord-048466-fj9l8che	37	30	some	some	DT
cord-048466-fj9l8che	37	31	degree	degree	NN
cord-048466-fj9l8che	37	32	of	of	IN
cord-048466-fj9l8che	37	33	herd	herd	NN
cord-048466-fj9l8che	37	34	immunity	immunity	NN
cord-048466-fj9l8che	37	35	against	against	IN
cord-048466-fj9l8che	37	36	the	the	DT
cord-048466-fj9l8che	37	37	new	new	JJ
cord-048466-fj9l8che	37	38	strain	strain	NN
cord-048466-fj9l8che	37	39	was	be	VBD
cord-048466-fj9l8che	37	40	expected	expect	VBN
cord-048466-fj9l8che	37	41	.	.	.
cord-048466-fj9l8che	38	1	The	the	DT
cord-048466-fj9l8che	38	2	H1N2	H1N2	NNP
cord-048466-fj9l8che	38	3	viruses	virus	NNS
cord-048466-fj9l8che	38	4	were	be	VBD
cord-048466-fj9l8che	38	5	not	not	RB
cord-048466-fj9l8che	38	6	associated	associate	VBN
cord-048466-fj9l8che	38	7	with	with	IN
cord-048466-fj9l8che	38	8	severe	severe	JJ
cord-048466-fj9l8che	38	9	influenza	influenza	NN
cord-048466-fj9l8che	38	10	illness	illness	NN
cord-048466-fj9l8che	38	11	that	that	DT
cord-048466-fj9l8che	38	12	season	season	NN
cord-048466-fj9l8che	38	13	.	.	.
cord-048466-fj9l8che	39	1	In	in	IN
cord-048466-fj9l8che	39	2	2002	2002	CD
cord-048466-fj9l8che	39	3	,	,	,
cord-048466-fj9l8che	39	4	a	a	DT
cord-048466-fj9l8che	39	5	new	new	JJ
cord-048466-fj9l8che	39	6	lineage	lineage	NN
cord-048466-fj9l8che	39	7	A	A	NNP
cord-048466-fj9l8che	39	8	/	/	SYM
cord-048466-fj9l8che	39	9	Fujian/411/02(H3N2)-like	Fujian/411/02(H3N2)-like	NNP
cord-048466-fj9l8che	39	10	emerged	emerge	VBD
cord-048466-fj9l8che	39	11	in	in	IN
cord-048466-fj9l8che	39	12	Asia	Asia	NNP
cord-048466-fj9l8che	39	13	and	and	CC
cord-048466-fj9l8che	39	14	caused	cause	VBD
cord-048466-fj9l8che	39	15	significant	significant	JJ
cord-048466-fj9l8che	39	16	outbreaks	outbreak	NNS
cord-048466-fj9l8che	39	17	on	on	IN
cord-048466-fj9l8che	39	18	every	every	DT
cord-048466-fj9l8che	39	19	continent	continent	NN
cord-048466-fj9l8che	39	20	[	[	-LRB-
cord-048466-fj9l8che	39	21	5	5	CD
cord-048466-fj9l8che	39	22	,	,	,
cord-048466-fj9l8che	39	23	6	6	CD
cord-048466-fj9l8che	39	24	]	]	-RRB-
cord-048466-fj9l8che	39	25	.	.	.
cord-048466-fj9l8che	40	1	For	for	IN
cord-048466-fj9l8che	40	2	the	the	DT
cord-048466-fj9l8che	40	3	northern	northern	JJ
cord-048466-fj9l8che	40	4	hemisphere	hemisphere	NN
cord-048466-fj9l8che	40	5	the	the	DT
cord-048466-fj9l8che	40	6	WHO	WHO	NNP
cord-048466-fj9l8che	40	7	issues	issue	VBZ
cord-048466-fj9l8che	40	8	the	the	DT
cord-048466-fj9l8che	40	9	recommendation	recommendation	NN
cord-048466-fj9l8che	40	10	for	for	IN
cord-048466-fj9l8che	40	11	strains	strain	NNS
cord-048466-fj9l8che	40	12	to	to	TO
cord-048466-fj9l8che	40	13	be	be	VB
cord-048466-fj9l8che	40	14	included	include	VBN
cord-048466-fj9l8che	40	15	in	in	IN
cord-048466-fj9l8che	40	16	the	the	DT
cord-048466-fj9l8che	40	17	trivalent	trivalent	JJ
cord-048466-fj9l8che	40	18	vaccine	vaccine	NN
cord-048466-fj9l8che	40	19	for	for	IN
cord-048466-fj9l8che	40	20	the	the	DT
cord-048466-fj9l8che	40	21	next	next	JJ
cord-048466-fj9l8che	40	22	season	season	NN
cord-048466-fj9l8che	40	23	based	base	VBN
cord-048466-fj9l8che	40	24	on	on	IN
cord-048466-fj9l8che	40	25	epidemiological	epidemiological	JJ
cord-048466-fj9l8che	40	26	data	datum	NNS
cord-048466-fj9l8che	40	27	and	and	CC
cord-048466-fj9l8che	40	28	antigenic	antigenic	JJ
cord-048466-fj9l8che	40	29	and	and	CC
cord-048466-fj9l8che	40	30	genetic	genetic	JJ
cord-048466-fj9l8che	40	31	analyses	analysis	NNS
cord-048466-fj9l8che	40	32	of	of	IN
cord-048466-fj9l8che	40	33	circulating	circulate	VBG
cord-048466-fj9l8che	40	34	strains	strain	NNS
cord-048466-fj9l8che	40	35	.	.	.
cord-048466-fj9l8che	41	1	Until	until	IN
cord-048466-fj9l8che	41	2	the	the	DT
cord-048466-fj9l8che	41	3	recent	recent	JJ
cord-048466-fj9l8che	41	4	release	release	NN
cord-048466-fj9l8che	41	5	of	of	IN
cord-048466-fj9l8che	41	6	over	over	IN
cord-048466-fj9l8che	41	7	1,800	1,800	CD
cord-048466-fj9l8che	41	8	complete	complete	JJ
cord-048466-fj9l8che	41	9	influenza	influenza	NN
cord-048466-fj9l8che	41	10	A	a	DT
cord-048466-fj9l8che	41	11	genome	genome	NN
cord-048466-fj9l8che	41	12	sequences	sequence	NNS
cord-048466-fj9l8che	41	13	from	from	IN
cord-048466-fj9l8che	41	14	the	the	DT
cord-048466-fj9l8che	41	15	Influenza	Influenza	NNP
cord-048466-fj9l8che	41	16	Genome	Genome	NNP
cord-048466-fj9l8che	41	17	Sequencing	Sequencing	NNP
cord-048466-fj9l8che	41	18	Project	Project	NNP
cord-048466-fj9l8che	41	19	managed	manage	VBN
cord-048466-fj9l8che	41	20	by	by	IN
cord-048466-fj9l8che	41	21	US	US	NNP
cord-048466-fj9l8che	41	22	National	National	NNP
cord-048466-fj9l8che	41	23	Institute	Institute	NNP
cord-048466-fj9l8che	41	24	of	of	IN
cord-048466-fj9l8che	41	25	Allergy	Allergy	NNP
cord-048466-fj9l8che	41	26	and	and	CC
cord-048466-fj9l8che	41	27	Infectious	Infectious	NNP
cord-048466-fj9l8che	41	28	Diseases	Diseases	NNPS
cord-048466-fj9l8che	41	29	[	[	-LRB-
cord-048466-fj9l8che	41	30	7	7	CD
cord-048466-fj9l8che	41	31	,	,	,
cord-048466-fj9l8che	41	32	8	8	CD
cord-048466-fj9l8che	41	33	]	]	-RRB-
cord-048466-fj9l8che	41	34	 	 	_SP
cord-048466-fj9l8che	41	35	The	the	DT
cord-048466-fj9l8che	41	36	relative	relative	JJ
cord-048466-fj9l8che	41	37	prevalence	prevalence	NN
cord-048466-fj9l8che	41	38	of	of	IN
cord-048466-fj9l8che	41	39	influenza	influenza	NN
cord-048466-fj9l8che	41	40	virus	virus	NN
cord-048466-fj9l8che	41	41	varies	vary	VBZ
cord-048466-fj9l8che	41	42	from	from	IN
cord-048466-fj9l8che	41	43	season	season	NN
cord-048466-fj9l8che	41	44	to	to	IN
cord-048466-fj9l8che	41	45	season	season	NN
cord-048466-fj9l8che	41	46	.	.	.
cord-048466-fj9l8che	42	1	Influenza	Influenza	NNP
cord-048466-fj9l8che	42	2	A	a	DT
cord-048466-fj9l8che	42	3	H3N2	H3N2	NNP
cord-048466-fj9l8che	42	4	was	be	VBD
cord-048466-fj9l8che	42	5	the	the	DT
cord-048466-fj9l8che	42	6	dominating	dominating	JJ
cord-048466-fj9l8che	42	7	strain	strain	NN
cord-048466-fj9l8che	42	8	in	in	IN
cord-048466-fj9l8che	42	9	Denmark	Denmark	NNP
cord-048466-fj9l8che	42	10	during	during	IN
cord-048466-fj9l8che	42	11	the	the	DT
cord-048466-fj9l8che	42	12	last	last	JJ
cord-048466-fj9l8che	42	13	seven	seven	CD
cord-048466-fj9l8che	42	14	years	year	NNS
cord-048466-fj9l8che	42	15	,	,	,
cord-048466-fj9l8che	42	16	with	with	IN
cord-048466-fj9l8che	42	17	the	the	DT
cord-048466-fj9l8che	42	18	exception	exception	NN
cord-048466-fj9l8che	42	19	of	of	IN
cord-048466-fj9l8che	42	20	the	the	DT
cord-048466-fj9l8che	42	21	2000	2000	CD
cord-048466-fj9l8che	42	22	-	-	SYM
cord-048466-fj9l8che	42	23	2001	2001	CD
cord-048466-fj9l8che	42	24	season	season	NN
cord-048466-fj9l8che	42	25	where	where	WRB
cord-048466-fj9l8che	42	26	the	the	DT
cord-048466-fj9l8che	42	27	H1N1	H1N1	NNP
cord-048466-fj9l8che	42	28	viruses	virus	NNS
cord-048466-fj9l8che	42	29	dominated	dominate	VBD
cord-048466-fj9l8che	42	30	,	,	,
cord-048466-fj9l8che	42	31	as	as	IN
cord-048466-fj9l8che	42	32	can	can	MD
cord-048466-fj9l8che	42	33	be	be	VB
cord-048466-fj9l8che	42	34	seen	see	VBN
cord-048466-fj9l8che	42	35	in	in	IN
cord-048466-fj9l8che	42	36	Figure	figure	NN
cord-048466-fj9l8che	42	37	1	1	CD
cord-048466-fj9l8che	42	38	.	.	.
cord-048466-fj9l8che	42	39	 	 	_SP
cord-048466-fj9l8che	43	1	Based	base	VBN
cord-048466-fj9l8che	43	2	on	on	IN
cord-048466-fj9l8che	43	3	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	43	4	analysis	analysis	NN
cord-048466-fj9l8che	43	5	of	of	IN
cord-048466-fj9l8che	43	6	the	the	DT
cord-048466-fj9l8che	43	7	HA	HA	NNP
cord-048466-fj9l8che	43	8	and	and	CC
cord-048466-fj9l8che	43	9	NA	NA	NNP
cord-048466-fj9l8che	43	10	nucleotide	nucleotide	JJ
cord-048466-fj9l8che	43	11	sequences	sequence	NNS
cord-048466-fj9l8che	43	12	from	from	IN
cord-048466-fj9l8che	43	13	1999	1999	CD
cord-048466-fj9l8che	43	14	to	to	IN
cord-048466-fj9l8che	43	15	2006	2006	CD
cord-048466-fj9l8che	44	1	(	(	-LRB-
cord-048466-fj9l8che	44	2	Figure	figure	NN
cord-048466-fj9l8che	44	3	2	2	CD
cord-048466-fj9l8che	44	4	)	)	-RRB-
cord-048466-fj9l8che	44	5	,	,	,
cord-048466-fj9l8che	44	6	ten	ten	CD
cord-048466-fj9l8che	44	7	isolates	isolate	NNS
cord-048466-fj9l8che	44	8	representative	representative	NN
cord-048466-fj9l8che	44	9	for	for	IN
cord-048466-fj9l8che	44	10	the	the	DT
cord-048466-fj9l8che	44	11	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	44	12	clustering	clustering	NN
cord-048466-fj9l8che	44	13	of	of	IN
cord-048466-fj9l8che	44	14	sequences	sequence	NNS
cord-048466-fj9l8che	44	15	from	from	IN
cord-048466-fj9l8che	44	16	each	each	DT
cord-048466-fj9l8che	44	17	subtype	subtype	NN
cord-048466-fj9l8che	44	18	in	in	IN
cord-048466-fj9l8che	44	19	each	each	DT
cord-048466-fj9l8che	44	20	season	season	NN
cord-048466-fj9l8che	44	21	,	,	,
cord-048466-fj9l8che	44	22	as	as	RB
cord-048466-fj9l8che	44	23	far	far	RB
cord-048466-fj9l8che	44	24	as	as	IN
cord-048466-fj9l8che	44	25	possible	possible	JJ
cord-048466-fj9l8che	44	26	,	,	,
cord-048466-fj9l8che	44	27	were	be	VBD
cord-048466-fj9l8che	44	28	included	include	VBN
cord-048466-fj9l8che	44	29	in	in	IN
cord-048466-fj9l8che	44	30	the	the	DT
cord-048466-fj9l8che	44	31	final	final	JJ
cord-048466-fj9l8che	44	32	HA	HA	NNP
cord-048466-fj9l8che	44	33	and	and	CC
cord-048466-fj9l8che	44	34	NA	NA	NNP
cord-048466-fj9l8che	44	35	tree	tree	NN
cord-048466-fj9l8che	44	36	(	(	-LRB-
cord-048466-fj9l8che	44	37	Figure	figure	NN
cord-048466-fj9l8che	44	38	2	2	CD
cord-048466-fj9l8che	44	39	)	)	-RRB-
cord-048466-fj9l8che	44	40	and	and	CC
cord-048466-fj9l8che	44	41	representatives	representative	NNS
cord-048466-fj9l8che	44	42	were	be	VBD
cord-048466-fj9l8che	44	43	chosen	choose	VBN
cord-048466-fj9l8che	44	44	for	for	IN
cord-048466-fj9l8che	44	45	complete	complete	JJ
cord-048466-fj9l8che	44	46	genome	genome	NN
cord-048466-fj9l8che	44	47	sequencing	sequencing	NN
cord-048466-fj9l8che	44	48	.	.	.
cord-048466-fj9l8che	45	1	Generally	generally	RB
cord-048466-fj9l8che	45	2	the	the	DT
cord-048466-fj9l8che	45	3	H3N2	H3N2	NNP
cord-048466-fj9l8che	45	4	HA	HA	NNP
cord-048466-fj9l8che	45	5	and	and	CC
cord-048466-fj9l8che	45	6	NA	NA	NNP
cord-048466-fj9l8che	45	7	genes	gene	NNS
cord-048466-fj9l8che	45	8	formed	form	VBD
cord-048466-fj9l8che	45	9	seasonal	seasonal	JJ
cord-048466-fj9l8che	45	10	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	45	11	clusters	cluster	NNS
cord-048466-fj9l8che	45	12	(	(	-LRB-
cord-048466-fj9l8che	45	13	Figure	figure	NN
cord-048466-fj9l8che	45	14	2	2	CD
cord-048466-fj9l8che	45	15	)	)	-RRB-
cord-048466-fj9l8che	45	16	.	.	.
cord-048466-fj9l8che	46	1	However	however	RB
cord-048466-fj9l8che	46	2	,	,	,
cord-048466-fj9l8che	46	3	we	-PRON-	PRP
cord-048466-fj9l8che	46	4	observed	observe	VBD
cord-048466-fj9l8che	46	5	that	that	IN
cord-048466-fj9l8che	46	6	strains	strain	NNS
cord-048466-fj9l8che	46	7	of	of	IN
cord-048466-fj9l8che	46	8	different	different	JJ
cord-048466-fj9l8che	46	9	lineages	lineage	NNS
cord-048466-fj9l8che	46	10	and	and	CC
cord-048466-fj9l8che	46	11	clusters	cluster	NNS
cord-048466-fj9l8che	46	12	cocirculated	cocirculate	VBN
cord-048466-fj9l8che	46	13	within	within	IN
cord-048466-fj9l8che	46	14	the	the	DT
cord-048466-fj9l8che	46	15	same	same	JJ
cord-048466-fj9l8che	46	16	season	season	NN
cord-048466-fj9l8che	46	17	and	and	CC
cord-048466-fj9l8che	46	18	that	that	IN
cord-048466-fj9l8che	46	19	viruses	virus	NNS
cord-048466-fj9l8che	46	20	had	have	VBD
cord-048466-fj9l8che	46	21	reassorted	reassorte	VBN
cord-048466-fj9l8che	46	22	with	with	IN
cord-048466-fj9l8che	46	23	viruses	virus	NNS
cord-048466-fj9l8che	46	24	from	from	IN
cord-048466-fj9l8che	46	25	previous	previous	JJ
cord-048466-fj9l8che	46	26	seasons	season	NNS
cord-048466-fj9l8che	47	1	(	(	-LRB-
cord-048466-fj9l8che	47	2	Figure	figure	NN
cord-048466-fj9l8che	47	3	2	2	CD
cord-048466-fj9l8che	47	4	)	)	-RRB-
cord-048466-fj9l8che	47	5	.	.	.
cord-048466-fj9l8che	48	1	The	the	DT
cord-048466-fj9l8che	48	2	HA	HA	NNP
cord-048466-fj9l8che	48	3	gene	gene	NN
cord-048466-fj9l8che	48	4	of	of	IN
cord-048466-fj9l8che	48	5	the	the	DT
cord-048466-fj9l8che	48	6	influenza	influenza	NN
cord-048466-fj9l8che	48	7	H3N2	H3N2	NNP
cord-048466-fj9l8che	48	8	strains	strain	VBZ
cord-048466-fj9l8che	48	9	from	from	IN
cord-048466-fj9l8che	48	10	the	the	DT
cord-048466-fj9l8che	48	11	1999	1999	CD
cord-048466-fj9l8che	48	12	-	-	SYM
cord-048466-fj9l8che	48	13	2000	2000	CD
cord-048466-fj9l8che	48	14	season	season	NN
cord-048466-fj9l8che	48	15	formed	form	VBD
cord-048466-fj9l8che	48	16	a	a	DT
cord-048466-fj9l8che	48	17	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	48	18	subclade	subclade	NN
cord-048466-fj9l8che	48	19	to	to	IN
cord-048466-fj9l8che	48	20	A/	A/	NNP
cord-048466-fj9l8che	48	21	Moscow/10/99(H3N2	Moscow/10/99(H3N2	NNP
cord-048466-fj9l8che	48	22	)	)	-RRB-
cord-048466-fj9l8che	48	23	and	and	CC
cord-048466-fj9l8che	48	24	A	a	DT
cord-048466-fj9l8che	48	25	/	/	SYM
cord-048466-fj9l8che	48	26	Sydney/5/97(H3N2	Sydney/5/97(H3N2	NNP
cord-048466-fj9l8che	48	27	)	)	-RRB-
cord-048466-fj9l8che	48	28	(	(	-LRB-
cord-048466-fj9l8che	48	29	represented	represent	VBN
cord-048466-fj9l8che	48	30	by	by	IN
cord-048466-fj9l8che	48	31	A	a	NN
cord-048466-fj9l8che	48	32	/	/	SYM
cord-048466-fj9l8che	48	33	Memphis/31/98	memphis/31/98	CD
cord-048466-fj9l8che	48	34	)	)	-RRB-
cord-048466-fj9l8che	49	1	(	(	-LRB-
cord-048466-fj9l8che	49	2	Figure	figure	NN
cord-048466-fj9l8che	49	3	2	2	CD
cord-048466-fj9l8che	49	4	)	)	-RRB-
cord-048466-fj9l8che	49	5	,	,	,
cord-048466-fj9l8che	49	6	located	locate	VBN
cord-048466-fj9l8che	49	7	between	between	IN
cord-048466-fj9l8che	49	8	A	A	NNP
cord-048466-fj9l8che	49	9	/	/	SYM
cord-048466-fj9l8che	49	10	Moscow/10/99	moscow/10/99	NN
cord-048466-fj9l8che	49	11	and	and	CC
cord-048466-fj9l8che	49	12	A/	A/	NNP
cord-048466-fj9l8che	50	1	Panama/2007/99	Panama/2007/99	NNP
cord-048466-fj9l8che	50	2	(	(	-LRB-
cord-048466-fj9l8che	50	3	not	not	RB
cord-048466-fj9l8che	50	4	shown	show	VBN
cord-048466-fj9l8che	50	5	)	)	-RRB-
cord-048466-fj9l8che	50	6	.	.	.
cord-048466-fj9l8che	51	1	The	the	DT
cord-048466-fj9l8che	51	2	antigenicity	antigenicity	NN
cord-048466-fj9l8che	51	3	of	of	IN
cord-048466-fj9l8che	51	4	these	these	DT
cord-048466-fj9l8che	51	5	strains	strain	NNS
cord-048466-fj9l8che	51	6	was	be	VBD
cord-048466-fj9l8che	51	7	A	a	NN
cord-048466-fj9l8che	51	8	/	/	SYM
cord-048466-fj9l8che	51	9	Moscow/	moscow/	NN
cord-048466-fj9l8che	51	10	10/99(H3N2)-like	10/99(h3n2)-like	CD
cord-048466-fj9l8che	51	11	in	in	IN
cord-048466-fj9l8che	51	12	a	a	DT
cord-048466-fj9l8che	51	13	haemagglutination	haemagglutination	NN
cord-048466-fj9l8che	51	14	inhibition	inhibition	NN
cord-048466-fj9l8che	51	15	assay	assay	NN
cord-048466-fj9l8che	51	16	,	,	,
cord-048466-fj9l8che	51	17	and	and	CC
cord-048466-fj9l8che	51	18	will	will	MD
cord-048466-fj9l8che	51	19	therefore	therefore	RB
cord-048466-fj9l8che	51	20	be	be	VB
cord-048466-fj9l8che	51	21	referred	refer	VBN
cord-048466-fj9l8che	51	22	to	to	IN
cord-048466-fj9l8che	51	23	as	as	IN
cord-048466-fj9l8che	51	24	Moscow	Moscow	NNP
cord-048466-fj9l8che	51	25	-	-	HYPH
cord-048466-fj9l8che	51	26	like	like	JJ
cord-048466-fj9l8che	51	27	throughout	throughout	IN
cord-048466-fj9l8che	51	28	this	this	DT
cord-048466-fj9l8che	51	29	report	report	NN
cord-048466-fj9l8che	51	30	.	.	.
cord-048466-fj9l8che	52	1	The	the	DT
cord-048466-fj9l8che	52	2	NA	NA	NNP
cord-048466-fj9l8che	52	3	and	and	CC
cord-048466-fj9l8che	52	4	the	the	DT
cord-048466-fj9l8che	52	5	internal	internal	JJ
cord-048466-fj9l8che	52	6	genes	gene	NNS
cord-048466-fj9l8che	52	7	were	be	VBD
cord-048466-fj9l8che	52	8	all	all	PDT
cord-048466-fj9l8che	52	9	A	a	NN
cord-048466-fj9l8che	52	10	/	/	SYM
cord-048466-fj9l8che	52	11	Moscow/10/99(H3N2)-like	moscow/10/99(h3n2)-like	XX
cord-048466-fj9l8che	52	12	,	,	,
cord-048466-fj9l8che	52	13	with	with	IN
cord-048466-fj9l8che	52	14	the	the	DT
cord-048466-fj9l8che	52	15	exception	exception	NN
cord-048466-fj9l8che	52	16	of	of	IN
cord-048466-fj9l8che	52	17	the	the	DT
cord-048466-fj9l8che	52	18	matrix	matrix	NN
cord-048466-fj9l8che	52	19	(	(	-LRB-
cord-048466-fj9l8che	52	20	M	M	NNP
cord-048466-fj9l8che	52	21	)	)	-RRB-
cord-048466-fj9l8che	52	22	gene	gene	NN
cord-048466-fj9l8che	52	23	that	that	WDT
cord-048466-fj9l8che	52	24	clustered	cluster	VBD
cord-048466-fj9l8che	52	25	as	as	IN
cord-048466-fj9l8che	52	26	a	a	DT
cord-048466-fj9l8che	52	27	subclade	subclade	NN
cord-048466-fj9l8che	52	28	to	to	IN
cord-048466-fj9l8che	52	29	the	the	DT
cord-048466-fj9l8che	52	30	A	A	NNP
cord-048466-fj9l8che	52	31	/	/	SYM
cord-048466-fj9l8che	52	32	New	New	NNP
cord-048466-fj9l8che	52	33	York/55/01-like	York/55/01-like	NNP
cord-048466-fj9l8che	52	34	strains	strain	NNS
cord-048466-fj9l8che	52	35	(	(	-LRB-
cord-048466-fj9l8che	52	36	Figure	figure	NN
cord-048466-fj9l8che	52	37	3	3	CD
cord-048466-fj9l8che	52	38	)	)	-RRB-
cord-048466-fj9l8che	52	39	.	.	.
cord-048466-fj9l8che	53	1	Figure	figure	NN
cord-048466-fj9l8che	53	2	1	1	CD
cord-048466-fj9l8che	53	3	)	)	-RRB-
cord-048466-fj9l8che	53	4	.	.	.
cord-048466-fj9l8che	54	1	Thirteen	thirteen	CD
cord-048466-fj9l8che	54	2	isolates	isolate	NNS
cord-048466-fj9l8che	54	3	from	from	IN
cord-048466-fj9l8che	54	4	this	this	DT
cord-048466-fj9l8che	54	5	season	season	NN
cord-048466-fj9l8che	54	6	were	be	VBD
cord-048466-fj9l8che	54	7	available	available	JJ
cord-048466-fj9l8che	54	8	for	for	IN
cord-048466-fj9l8che	54	9	sequencing	sequencing	NN
cord-048466-fj9l8che	54	10	,	,	,
cord-048466-fj9l8che	54	11	and	and	CC
cord-048466-fj9l8che	54	12	all	all	DT
cord-048466-fj9l8che	54	13	were	be	VBD
cord-048466-fj9l8che	54	14	of	of	IN
cord-048466-fj9l8che	54	15	the	the	DT
cord-048466-fj9l8che	54	16	H1N1	H1N1	NNP
cord-048466-fj9l8che	54	17	subtype	subtype	NN
cord-048466-fj9l8che	54	18	.	.	.
cord-048466-fj9l8che	55	1	These	these	DT
cord-048466-fj9l8che	55	2	sequences	sequence	NNS
cord-048466-fj9l8che	55	3	represented	represent	VBD
cord-048466-fj9l8che	55	4	two	two	CD
cord-048466-fj9l8che	55	5	different	different	JJ
cord-048466-fj9l8che	55	6	co	co	NN
cord-048466-fj9l8che	55	7	-	-	JJ
cord-048466-fj9l8che	55	8	circulating	circulating	JJ
cord-048466-fj9l8che	55	9	lineages	lineage	NNS
cord-048466-fj9l8che	55	10	(	(	-LRB-
cord-048466-fj9l8che	55	11	Figure	figure	NN
cord-048466-fj9l8che	55	12	4	4	CD
cord-048466-fj9l8che	55	13	)	)	-RRB-
cord-048466-fj9l8che	55	14	.	.	.
cord-048466-fj9l8che	56	1	Lineage	lineage	NN
cord-048466-fj9l8che	56	2	I	-PRON-	PRP
cord-048466-fj9l8che	56	3	is	be	VBZ
cord-048466-fj9l8che	56	4	A	A	NNP
cord-048466-fj9l8che	56	5	/	/	SYM
cord-048466-fj9l8che	56	6	Bayern/7/	Bayern/7/	NNP
cord-048466-fj9l8che	56	7	95(H1N1)-like	95(h1n1)-like	CD
cord-048466-fj9l8che	56	8	and	and	CC
cord-048466-fj9l8che	56	9	lineage	lineage	NN
cord-048466-fj9l8che	56	10	II	ii	CD
cord-048466-fj9l8che	56	11	include	include	VBP
cord-048466-fj9l8che	56	12	the	the	DT
cord-048466-fj9l8che	56	13	H1N1	H1N1	NNP
cord-048466-fj9l8che	56	14	strains	strain	NNS
cord-048466-fj9l8che	56	15	of	of	IN
cord-048466-fj9l8che	56	16	today	today	NN
cord-048466-fj9l8che	56	17	and	and	CC
cord-048466-fj9l8che	56	18	the	the	DT
cord-048466-fj9l8che	56	19	A	A	NNP
cord-048466-fj9l8che	56	20	/	/	SYM
cord-048466-fj9l8che	56	21	New	New	NNP
cord-048466-fj9l8che	56	22	Caledonia/20/99(H1N1	Caledonia/20/99(H1N1	NNP
cord-048466-fj9l8che	56	23	)	)	-RRB-
cord-048466-fj9l8che	56	24	vaccine	vaccine	NN
cord-048466-fj9l8che	56	25	reference	reference	NN
cord-048466-fj9l8che	56	26	strain	strain	NN
cord-048466-fj9l8che	56	27	(	(	-LRB-
cord-048466-fj9l8che	56	28	Figure	figure	NN
cord-048466-fj9l8che	56	29	4	4	CD
cord-048466-fj9l8che	56	30	)	)	-RRB-
cord-048466-fj9l8che	56	31	.	.	.
cord-048466-fj9l8che	57	1	The	the	DT
cord-048466-fj9l8che	57	2	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	57	3	trees	tree	NNS
cord-048466-fj9l8che	57	4	of	of	IN
cord-048466-fj9l8che	57	5	NA	NA	NNP
cord-048466-fj9l8che	57	6	and	and	CC
cord-048466-fj9l8che	57	7	the	the	DT
cord-048466-fj9l8che	57	8	internal	internal	JJ
cord-048466-fj9l8che	57	9	genes	gene	NNS
cord-048466-fj9l8che	57	10	showed	show	VBD
cord-048466-fj9l8che	57	11	the	the	DT
cord-048466-fj9l8che	57	12	same	same	JJ
cord-048466-fj9l8che	57	13	topology	topology	NN
cord-048466-fj9l8che	57	14	(	(	-LRB-
cord-048466-fj9l8che	57	15	Figure	figure	VB
cord-048466-fj9l8che	57	16	 	 	_SP
cord-048466-fj9l8che	57	17	3	3	CD
cord-048466-fj9l8che	57	18	and	and	CC
cord-048466-fj9l8che	57	19	4	4	CD
cord-048466-fj9l8che	57	20	)	)	-RRB-
cord-048466-fj9l8che	57	21	.	.	.
cord-048466-fj9l8che	58	1	The	the	DT
cord-048466-fj9l8che	58	2	lineage	lineage	NN
cord-048466-fj9l8che	58	3	II	ii	CD
cord-048466-fj9l8che	58	4	strains	strain	NNS
cord-048466-fj9l8che	58	5	are	be	VBP
cord-048466-fj9l8che	58	6	characterised	characterise	VBN
cord-048466-fj9l8che	58	7	by	by	IN
cord-048466-fj9l8che	58	8	a	a	DT
cord-048466-fj9l8che	58	9	deletion	deletion	NN
cord-048466-fj9l8che	58	10	K130	k130	CD
cord-048466-fj9l8che	58	11	in	in	IN
cord-048466-fj9l8che	58	12	HA	HA	NNP
cord-048466-fj9l8che	58	13	(	(	-LRB-
cord-048466-fj9l8che	58	14	K134	k134	CD
cord-048466-fj9l8che	58	15	in	in	IN
cord-048466-fj9l8che	58	16	H3	H3	NNP
cord-048466-fj9l8che	58	17	numbering	number	VBG
cord-048466-fj9l8che	58	18	)	)	-RRB-
cord-048466-fj9l8che	58	19	(	(	-LRB-
cord-048466-fj9l8che	58	20	Table	table	NN
cord-048466-fj9l8che	58	21	1	1	CD
cord-048466-fj9l8che	58	22	)	)	-RRB-
cord-048466-fj9l8che	58	23	 	 	_SP
cord-048466-fj9l8che	59	1	*	*	NFP
cord-048466-fj9l8che	59	2	Amino	amino	NN
cord-048466-fj9l8che	59	3	acids	acid	NNS
cord-048466-fj9l8che	59	4	in	in	IN
cord-048466-fj9l8che	59	5	brackets	bracket	NNS
cord-048466-fj9l8che	59	6	indicate	indicate	VBP
cord-048466-fj9l8che	59	7	less	less	JJR
cord-048466-fj9l8che	59	8	than	than	IN
cord-048466-fj9l8che	59	9	half	half	NN
cord-048466-fj9l8che	59	10	but	but	CC
cord-048466-fj9l8che	59	11	more	more	JJR
cord-048466-fj9l8che	59	12	than	than	IN
cord-048466-fj9l8che	59	13	two	two	CD
cord-048466-fj9l8che	59	14	substitutions	substitution	NNS
cord-048466-fj9l8che	59	15	at	at	IN
cord-048466-fj9l8che	59	16	the	the	DT
cord-048466-fj9l8che	59	17	given	give	VBN
cord-048466-fj9l8che	59	18	amino	amino	NN
cord-048466-fj9l8che	59	19	acid	acid	NN
cord-048466-fj9l8che	59	20	position	position	NN
cord-048466-fj9l8che	59	21	within	within	IN
cord-048466-fj9l8che	59	22	a	a	DT
cord-048466-fj9l8che	59	23	season	season	NN
cord-048466-fj9l8che	59	24	.	.	.
cord-048466-fj9l8che	60	1	A	a	DT
cord-048466-fj9l8che	60	2	single	single	JJ
cord-048466-fj9l8che	60	3	amino	amino	NN
cord-048466-fj9l8che	60	4	acid	acid	NN
cord-048466-fj9l8che	60	5	change	change	NN
cord-048466-fj9l8che	60	6	in	in	IN
cord-048466-fj9l8che	60	7	one	one	CD
cord-048466-fj9l8che	60	8	position	position	NN
cord-048466-fj9l8che	60	9	is	be	VBZ
cord-048466-fj9l8che	60	10	not	not	RB
cord-048466-fj9l8che	60	11	shown	show	VBN
cord-048466-fj9l8che	60	12	.	.	.
cord-048466-fj9l8che	61	1	Amino	amino	NN
cord-048466-fj9l8che	61	2	acids	acid	NNS
cord-048466-fj9l8che	61	3	separated	separate	VBN
cord-048466-fj9l8che	61	4	by	by	IN
cord-048466-fj9l8che	61	5	'	'	''
cord-048466-fj9l8che	61	6	/	/	SYM
cord-048466-fj9l8che	61	7	'	'	``
cord-048466-fj9l8che	61	8	indicate	indicate	VBP
cord-048466-fj9l8che	61	9	equal	equal	JJ
cord-048466-fj9l8che	61	10	substitutions	substitution	NNS
cord-048466-fj9l8che	61	11	of	of	IN
cord-048466-fj9l8che	61	12	either	either	DT
cord-048466-fj9l8che	61	13	amino	amino	NN
cord-048466-fj9l8che	61	14	acid	acid	NN
cord-048466-fj9l8che	61	15	at	at	IN
cord-048466-fj9l8che	61	16	the	the	DT
cord-048466-fj9l8che	61	17	given	give	VBN
cord-048466-fj9l8che	61	18	position	position	NN
cord-048466-fj9l8che	61	19	.	.	.
cord-048466-fj9l8che	62	1	Letters	letter	NNS
cord-048466-fj9l8che	62	2	in	in	IN
cord-048466-fj9l8che	62	3	upper	upper	JJ
cord-048466-fj9l8che	62	4	case	case	NN
cord-048466-fj9l8che	62	5	above	above	IN
cord-048466-fj9l8che	62	6	an	an	DT
cord-048466-fj9l8che	62	7	amino	amino	NN
cord-048466-fj9l8che	62	8	acid	acid	NN
cord-048466-fj9l8che	62	9	indicate	indicate	VBP
cord-048466-fj9l8che	62	10	the	the	DT
cord-048466-fj9l8che	62	11	antigenic	antigenic	JJ
cord-048466-fj9l8che	62	12	site	site	NN
cord-048466-fj9l8che	62	13	location	location	NN
cord-048466-fj9l8che	62	14	of	of	IN
cord-048466-fj9l8che	62	15	the	the	DT
cord-048466-fj9l8che	62	16	residue	residue	NN
cord-048466-fj9l8che	62	17	.	.	.
cord-048466-fj9l8che	63	1	In	in	IN
cord-048466-fj9l8che	63	2	N1	N1	NNP
cord-048466-fj9l8che	63	3	the	the	DT
cord-048466-fj9l8che	63	4	upper	upper	JJ
cord-048466-fj9l8che	63	5	case	case	NN
cord-048466-fj9l8che	63	6	letter	letter	NN
cord-048466-fj9l8che	63	7	'	'	``
cord-048466-fj9l8che	63	8	P	p	NN
cord-048466-fj9l8che	63	9	'	'	''
cord-048466-fj9l8che	63	10	stands	stand	VBZ
cord-048466-fj9l8che	63	11	for	for	IN
cord-048466-fj9l8che	63	12	phylogenetically	phylogenetically	RB
cord-048466-fj9l8che	63	13	important	important	JJ
cord-048466-fj9l8che	63	14	region	region	NN
cord-048466-fj9l8che	63	15	(	(	-LRB-
cord-048466-fj9l8che	63	16	PIR	PIR	NNP
cord-048466-fj9l8che	63	17	)	)	-RRB-
cord-048466-fj9l8che	63	18	and	and	CC
cord-048466-fj9l8che	63	19	the	the	DT
cord-048466-fj9l8che	63	20	following	follow	VBG
cord-048466-fj9l8che	63	21	letters	letter	NNS
cord-048466-fj9l8che	63	22	indicate	indicate	VBP
cord-048466-fj9l8che	63	23	the	the	DT
cord-048466-fj9l8che	63	24	actual	actual	JJ
cord-048466-fj9l8che	63	25	PIR	PIR	NNP
cord-048466-fj9l8che	63	26	.	.	.
cord-048466-fj9l8che	64	1	Based	base	VBN
cord-048466-fj9l8che	64	2	on	on	IN
cord-048466-fj9l8che	64	3	the	the	DT
cord-048466-fj9l8che	64	4	ratio	ratio	NN
cord-048466-fj9l8che	64	5	of	of	IN
cord-048466-fj9l8che	64	6	non	non	JJ
cord-048466-fj9l8che	64	7	-	-	JJ
cord-048466-fj9l8che	64	8	synonymous	synonymous	JJ
cord-048466-fj9l8che	64	9	versus	versus	IN
cord-048466-fj9l8che	64	10	synonymous	synonymous	JJ
cord-048466-fj9l8che	64	11	substitutions	substitution	NNS
cord-048466-fj9l8che	64	12	none	none	NN
cord-048466-fj9l8che	64	13	of	of	IN
cord-048466-fj9l8che	64	14	the	the	DT
cord-048466-fj9l8che	64	15	influenza	influenza	NN
cord-048466-fj9l8che	64	16	A	a	DT
cord-048466-fj9l8che	64	17	genes	gene	NNS
cord-048466-fj9l8che	64	18	were	be	VBD
cord-048466-fj9l8che	64	19	directly	directly	RB
cord-048466-fj9l8che	64	20	influenced	influence	VBN
cord-048466-fj9l8che	64	21	by	by	IN
cord-048466-fj9l8che	64	22	positive	positive	JJ
cord-048466-fj9l8che	64	23	selection	selection	NN
cord-048466-fj9l8che	64	24	(	(	-LRB-
cord-048466-fj9l8che	64	25	dN	dN	NNP
cord-048466-fj9l8che	64	26	/	/	SYM
cord-048466-fj9l8che	64	27	dS<1	dS<1	NNP
cord-048466-fj9l8che	64	28	)	)	-RRB-
cord-048466-fj9l8che	65	1	(	(	-LRB-
cord-048466-fj9l8che	65	2	Table	table	NN
cord-048466-fj9l8che	65	3	 	 	_SP
cord-048466-fj9l8che	65	4	3	3	CD
cord-048466-fj9l8che	65	5	)	)	-RRB-
cord-048466-fj9l8che	65	6	.	.	.
cord-048466-fj9l8che	66	1	However	however	RB
cord-048466-fj9l8che	66	2	,	,	,
cord-048466-fj9l8che	66	3	as	as	IN
cord-048466-fj9l8che	66	4	expected	expect	VBN
cord-048466-fj9l8che	66	5	the	the	DT
cord-048466-fj9l8che	66	6	HA1	HA1	NNP
cord-048466-fj9l8che	66	7	region	region	NN
cord-048466-fj9l8che	66	8	of	of	IN
cord-048466-fj9l8che	66	9	both	both	CC
cord-048466-fj9l8che	66	10	H3	H3	NNP
cord-048466-fj9l8che	66	11	and	and	CC
cord-048466-fj9l8che	66	12	H1	h1	NN
cord-048466-fj9l8che	66	13	viruses	virus	NNS
cord-048466-fj9l8che	66	14	were	be	VBD
cord-048466-fj9l8che	66	15	more	more	RBR
cord-048466-fj9l8che	66	16	influenced	influence	VBN
cord-048466-fj9l8che	66	17	by	by	IN
cord-048466-fj9l8che	66	18	evolutionary	evolutionary	JJ
cord-048466-fj9l8che	66	19	pressure	pressure	NN
cord-048466-fj9l8che	66	20	(	(	-LRB-
cord-048466-fj9l8che	66	21	Table	Table	NNP
cord-048466-fj9l8che	66	22	3	3	CD
cord-048466-fj9l8che	66	23	)	)	-RRB-
cord-048466-fj9l8che	66	24	.	.	.
cord-048466-fj9l8che	67	1	We	-PRON-	PRP
cord-048466-fj9l8che	67	2	applied	apply	VBD
cord-048466-fj9l8che	67	3	FEL	FEL	NNP
cord-048466-fj9l8che	67	4	and	and	CC
cord-048466-fj9l8che	67	5	SLAC	SLAC	NNP
cord-048466-fj9l8che	67	6	maximum	maximum	JJ
cord-048466-fj9l8che	67	7	-	-	HYPH
cord-048466-fj9l8che	67	8	likelihood	likelihood	NN
cord-048466-fj9l8che	67	9	methods	method	NNS
cord-048466-fj9l8che	67	10	to	to	TO
cord-048466-fj9l8che	67	11	estimate	estimate	VB
cord-048466-fj9l8che	67	12	individual	individual	JJ
cord-048466-fj9l8che	67	13	positively	positively	RB
cord-048466-fj9l8che	67	14	selected	select	VBN
cord-048466-fj9l8che	67	15	sites	site	NNS
cord-048466-fj9l8che	67	16	in	in	IN
cord-048466-fj9l8che	67	17	H3N2	H3N2	NNP
cord-048466-fj9l8che	67	18	HA	HA	NNP
cord-048466-fj9l8che	67	19	and	and	CC
cord-048466-fj9l8che	67	20	NA	NA	NNP
cord-048466-fj9l8che	67	21	and	and	CC
cord-048466-fj9l8che	67	22	added	add	VBD
cord-048466-fj9l8che	67	23	REL	REL	NNP
cord-048466-fj9l8che	67	24	for	for	IN
cord-048466-fj9l8che	67	25	smaller	small	JJR
cord-048466-fj9l8che	67	26	datasets	dataset	NNS
cord-048466-fj9l8che	67	27	in	in	IN
cord-048466-fj9l8che	67	28	all	all	DT
cord-048466-fj9l8che	67	29	genes	gene	NNS
cord-048466-fj9l8che	67	30	(	(	-LRB-
cord-048466-fj9l8che	67	31	se	se	FW
cord-048466-fj9l8che	67	32	methods	method	NNS
cord-048466-fj9l8che	67	33	section	section	NN
cord-048466-fj9l8che	67	34	)	)	-RRB-
cord-048466-fj9l8che	67	35	.	.	.
cord-048466-fj9l8che	68	1	The	the	DT
cord-048466-fj9l8che	68	2	FEL	FEL	NNP
cord-048466-fj9l8che	68	3	method	method	NN
cord-048466-fj9l8che	68	4	found	find	VBD
cord-048466-fj9l8che	68	5	one	one	CD
cord-048466-fj9l8che	68	6	site	site	NN
cord-048466-fj9l8che	68	7	in	in	IN
cord-048466-fj9l8che	68	8	the	the	DT
cord-048466-fj9l8che	68	9	H3	H3	NNP
cord-048466-fj9l8che	68	10	protein	protein	NN
cord-048466-fj9l8che	68	11	(	(	-LRB-
cord-048466-fj9l8che	68	12	n	n	NN
cord-048466-fj9l8che	68	13	=	=	SYM
cord-048466-fj9l8che	68	14	204	204	CD
cord-048466-fj9l8che	68	15	)	)	-RRB-
cord-048466-fj9l8che	68	16	,	,	,
cord-048466-fj9l8che	68	17	position	position	VBP
cord-048466-fj9l8che	68	18	199	199	CD
cord-048466-fj9l8che	69	1	(	(	-LRB-
cord-048466-fj9l8che	69	2	p	p	NN
cord-048466-fj9l8che	69	3	=	=	SYM
cord-048466-fj9l8che	69	4	0.046	0.046	CD
cord-048466-fj9l8che	69	5	)	)	-RRB-
cord-048466-fj9l8che	69	6	to	to	TO
cord-048466-fj9l8che	69	7	be	be	VB
cord-048466-fj9l8che	69	8	positively	positively	RB
cord-048466-fj9l8che	69	9	selected	select	VBN
cord-048466-fj9l8che	69	10	,	,	,
cord-048466-fj9l8che	69	11	while	while	IN
cord-048466-fj9l8che	69	12	the	the	DT
cord-048466-fj9l8che	69	13	more	more	RBR
cord-048466-fj9l8che	69	14	conservative	conservative	JJ
cord-048466-fj9l8che	69	15	SLAC	SLAC	NNP
cord-048466-fj9l8che	69	16	analysis	analysis	NN
cord-048466-fj9l8che	69	17	found	find	VBD
cord-048466-fj9l8che	69	18	none	none	NN
cord-048466-fj9l8che	69	19	.	.	.
cord-048466-fj9l8che	70	1	No	no	DT
cord-048466-fj9l8che	70	2	positive	positive	JJ
cord-048466-fj9l8che	70	3	selected	select	VBN
cord-048466-fj9l8che	70	4	sites	site	NNS
cord-048466-fj9l8che	70	5	were	be	VBD
cord-048466-fj9l8che	70	6	predicted	predict	VBN
cord-048466-fj9l8che	70	7	for	for	IN
cord-048466-fj9l8che	70	8	the	the	DT
cord-048466-fj9l8che	70	9	N2	N2	NNP
cord-048466-fj9l8che	70	10	genes	gene	NNS
cord-048466-fj9l8che	70	11	(	(	-LRB-
cord-048466-fj9l8che	70	12	n	n	NN
cord-048466-fj9l8che	70	13	=	=	SYM
cord-048466-fj9l8che	70	14	166	166	CD
cord-048466-fj9l8che	70	15	)	)	-RRB-
cord-048466-fj9l8che	70	16	and	and	CC
cord-048466-fj9l8che	70	17	none	none	NN
cord-048466-fj9l8che	70	18	in	in	IN
cord-048466-fj9l8che	70	19	the	the	DT
cord-048466-fj9l8che	70	20	internal	internal	JJ
cord-048466-fj9l8che	70	21	genes	gene	NNS
cord-048466-fj9l8che	70	22	(	(	-LRB-
cord-048466-fj9l8che	70	23	n	n	NN
cord-048466-fj9l8che	70	24	=	=	SYM
cord-048466-fj9l8che	70	25	15	15	CD
cord-048466-fj9l8che	70	26	)	)	-RRB-
cord-048466-fj9l8che	70	27	estimated	estimate	VBN
cord-048466-fj9l8che	70	28	by	by	IN
cord-048466-fj9l8che	70	29	FEL	FEL	NNP
cord-048466-fj9l8che	70	30	and	and	CC
cord-048466-fj9l8che	70	31	SLAC	SLAC	NNP
cord-048466-fj9l8che	70	32	.	.	.
cord-048466-fj9l8che	71	1	The	the	DT
cord-048466-fj9l8che	71	2	REL	REL	NNP
cord-048466-fj9l8che	71	3	analysis	analysis	NN
cord-048466-fj9l8che	71	4	retrieved	retrieve	VBD
cord-048466-fj9l8che	71	5	four	four	CD
cord-048466-fj9l8che	71	6	sites	site	NNS
cord-048466-fj9l8che	71	7	in	in	IN
cord-048466-fj9l8che	71	8	the	the	DT
cord-048466-fj9l8che	71	9	M1	M1	NNP
cord-048466-fj9l8che	71	10	gene	gene	NN
cord-048466-fj9l8che	71	11	to	to	TO
cord-048466-fj9l8che	71	12	be	be	VB
cord-048466-fj9l8che	71	13	selected	select	VBN
cord-048466-fj9l8che	71	14	namely	namely	RB
cord-048466-fj9l8che	71	15	positions	position	NNS
cord-048466-fj9l8che	71	16	208	208	CD
cord-048466-fj9l8che	71	17	,	,	,
cord-048466-fj9l8che	71	18	211	211	CD
cord-048466-fj9l8che	71	19	,	,	,
cord-048466-fj9l8che	71	20	218	218	CD
cord-048466-fj9l8che	71	21	and	and	CC
cord-048466-fj9l8che	71	22	219	219	CD
cord-048466-fj9l8che	71	23	.	.	.
cord-048466-fj9l8che	72	1	No	no	DT
cord-048466-fj9l8che	72	2	sites	site	NNS
cord-048466-fj9l8che	72	3	in	in	IN
cord-048466-fj9l8che	72	4	HA	HA	NNP
cord-048466-fj9l8che	72	5	(	(	-LRB-
cord-048466-fj9l8che	72	6	n	n	NN
cord-048466-fj9l8che	72	7	=	=	SYM
cord-048466-fj9l8che	72	8	27	27	CD
cord-048466-fj9l8che	72	9	)	)	-RRB-
cord-048466-fj9l8che	72	10	and	and	CC
cord-048466-fj9l8che	72	11	NA	NA	NNP
cord-048466-fj9l8che	72	12	(	(	-LRB-
cord-048466-fj9l8che	72	13	n	n	NN
cord-048466-fj9l8che	72	14	=	=	SYM
cord-048466-fj9l8che	72	15	30	30	CD
cord-048466-fj9l8che	72	16	)	)	-RRB-
cord-048466-fj9l8che	72	17	of	of	IN
cord-048466-fj9l8che	72	18	the	the	DT
cord-048466-fj9l8che	72	19	H1N1	H1N1	NNP
cord-048466-fj9l8che	72	20	viruses	virus	NNS
cord-048466-fj9l8che	72	21	were	be	VBD
cord-048466-fj9l8che	72	22	directly	directly	RB
cord-048466-fj9l8che	72	23	positively	positively	RB
cord-048466-fj9l8che	72	24	selected	select	VBN
cord-048466-fj9l8che	72	25	with	with	IN
cord-048466-fj9l8che	72	26	any	any	DT
cord-048466-fj9l8che	72	27	of	of	IN
cord-048466-fj9l8che	72	28	the	the	DT
cord-048466-fj9l8che	72	29	three	three	CD
cord-048466-fj9l8che	72	30	methods	method	NNS
cord-048466-fj9l8che	72	31	of	of	IN
cord-048466-fj9l8che	72	32	analysis	analysis	NN
cord-048466-fj9l8che	72	33	.	.	.
cord-048466-fj9l8che	73	1	[	[	-LRB-
cord-048466-fj9l8che	73	2	26	26	CD
cord-048466-fj9l8che	73	3	]	]	-RRB-
cord-048466-fj9l8che	73	4	and	and	CC
cord-048466-fj9l8che	73	5	it	-PRON-	PRP
cord-048466-fj9l8che	73	6	was	be	VBD
cord-048466-fj9l8che	73	7	anticipated	anticipate	VBN
cord-048466-fj9l8che	73	8	that	that	IN
cord-048466-fj9l8che	73	9	there	there	EX
cord-048466-fj9l8che	73	10	would	would	MD
cord-048466-fj9l8che	73	11	be	be	VB
cord-048466-fj9l8che	73	12	some	some	DT
cord-048466-fj9l8che	73	13	extent	extent	NN
cord-048466-fj9l8che	73	14	of	of	IN
cord-048466-fj9l8che	73	15	herd	herd	NN
cord-048466-fj9l8che	73	16	immunity	immunity	NN
cord-048466-fj9l8che	73	17	in	in	IN
cord-048466-fj9l8che	73	18	the	the	DT
cord-048466-fj9l8che	73	19	population	population	NN
cord-048466-fj9l8che	73	20	against	against	IN
cord-048466-fj9l8che	73	21	this	this	DT
cord-048466-fj9l8che	73	22	new	new	JJ
cord-048466-fj9l8che	73	23	reassortant	reassortant	NN
cord-048466-fj9l8che	73	24	.	.	.
cord-048466-fj9l8che	74	1	The	the	DT
cord-048466-fj9l8che	74	2	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	74	3	trees	tree	NNS
cord-048466-fj9l8che	74	4	of	of	IN
cord-048466-fj9l8che	74	5	H3N2	H3N2	NNP
cord-048466-fj9l8che	74	6	HA	HA	NNP
cord-048466-fj9l8che	74	7	and	and	CC
cord-048466-fj9l8che	74	8	NA	NA	NNP
cord-048466-fj9l8che	74	9	showed	show	VBD
cord-048466-fj9l8che	74	10	seasonal	seasonal	JJ
cord-048466-fj9l8che	74	11	clusters	cluster	NNS
cord-048466-fj9l8che	74	12	but	but	CC
cord-048466-fj9l8che	74	13	also	also	RB
cord-048466-fj9l8che	74	14	co	co	VBD
cord-048466-fj9l8che	74	15	-	-	JJ
cord-048466-fj9l8che	74	16	circulating	circulating	JJ
cord-048466-fj9l8che	74	17	lineages	lineage	NNS
cord-048466-fj9l8che	74	18	within	within	IN
cord-048466-fj9l8che	74	19	seasons	season	NNS
cord-048466-fj9l8che	74	20	.	.	.
cord-048466-fj9l8che	75	1	The	the	DT
cord-048466-fj9l8che	75	2	introduction	introduction	NN
cord-048466-fj9l8che	75	3	of	of	IN
cord-048466-fj9l8che	75	4	the	the	DT
cord-048466-fj9l8che	75	5	A	A	NNP
cord-048466-fj9l8che	75	6	/	/	SYM
cord-048466-fj9l8che	75	7	Fujian/411/02(H3N2	fujian/411/02(h3n2	JJ
cord-048466-fj9l8che	75	8	)	)	-RRB-
cord-048466-fj9l8che	75	9	strains	strain	NNS
cord-048466-fj9l8che	75	10	in	in	IN
cord-048466-fj9l8che	75	11	2002	2002	CD
cord-048466-fj9l8che	75	12	-	-	SYM
cord-048466-fj9l8che	75	13	2003	2003	CD
cord-048466-fj9l8che	75	14	caused	cause	VBD
cord-048466-fj9l8che	75	15	a	a	DT
cord-048466-fj9l8che	75	16	"	"	``
cord-048466-fj9l8che	75	17	jump	jump	NN
cord-048466-fj9l8che	75	18	"	"	''
cord-048466-fj9l8che	75	19	in	in	IN
cord-048466-fj9l8che	75	20	the	the	DT
cord-048466-fj9l8che	75	21	evolution	evolution	NN
cord-048466-fj9l8che	75	22	of	of	IN
cord-048466-fj9l8che	75	23	both	both	DT
cord-048466-fj9l8che	75	24	HA	HA	NNP
cord-048466-fj9l8che	75	25	and	and	CC
cord-048466-fj9l8che	75	26	NA	NA	NNP
cord-048466-fj9l8che	75	27	genes	gene	NNS
cord-048466-fj9l8che	75	28	.	.	.
cord-048466-fj9l8che	76	1	Many	many	JJ
cord-048466-fj9l8che	76	2	of	of	IN
cord-048466-fj9l8che	76	3	the	the	DT
cord-048466-fj9l8che	76	4	substitutions	substitution	NNS
cord-048466-fj9l8che	76	5	in	in	IN
cord-048466-fj9l8che	76	6	HA	HA	NNP
cord-048466-fj9l8che	76	7	introduced	introduce	VBD
cord-048466-fj9l8che	76	8	with	with	IN
cord-048466-fj9l8che	76	9	the	the	DT
cord-048466-fj9l8che	76	10	A	A	NNP
cord-048466-fj9l8che	76	11	/	/	SYM
cord-048466-fj9l8che	76	12	Fujian/411/02(H3N2)-like	Fujian/411/02(H3N2)-like	NNP
cord-048466-fj9l8che	76	13	viruses	virus	NNS
cord-048466-fj9l8che	76	14	have	have	VBP
cord-048466-fj9l8che	76	15	become	become	VBN
cord-048466-fj9l8che	76	16	fixed	fix	VBN
cord-048466-fj9l8che	76	17	,	,	,
cord-048466-fj9l8che	76	18	probably	probably	RB
cord-048466-fj9l8che	76	19	reflecting	reflect	VBG
cord-048466-fj9l8che	76	20	a	a	DT
cord-048466-fj9l8che	76	21	very	very	RB
cord-048466-fj9l8che	76	22	fit	fit	JJ
cord-048466-fj9l8che	76	23	virus	virus	NN
cord-048466-fj9l8che	76	24	.	.	.
cord-048466-fj9l8che	77	1	The	the	DT
cord-048466-fj9l8che	77	2	genetic	genetic	JJ
cord-048466-fj9l8che	77	3	variation	variation	NN
cord-048466-fj9l8che	77	4	before	before	IN
cord-048466-fj9l8che	77	5	the	the	DT
cord-048466-fj9l8che	77	6	2003	2003	CD
cord-048466-fj9l8che	77	7	-	-	SYM
cord-048466-fj9l8che	77	8	2004	2004	CD
cord-048466-fj9l8che	77	9	season	season	NN
cord-048466-fj9l8che	77	10	may	may	MD
cord-048466-fj9l8che	77	11	have	have	VB
cord-048466-fj9l8che	77	12	been	be	VBN
cord-048466-fj9l8che	77	13	more	more	RBR
cord-048466-fj9l8che	77	14	influenced	influence	VBN
cord-048466-fj9l8che	77	15	by	by	IN
cord-048466-fj9l8che	77	16	introduction	introduction	NN
cord-048466-fj9l8che	77	17	of	of	IN
cord-048466-fj9l8che	77	18	new	new	JJ
cord-048466-fj9l8che	77	19	viruses	virus	NNS
cord-048466-fj9l8che	77	20	through	through	IN
cord-048466-fj9l8che	77	21	viral	viral	JJ
cord-048466-fj9l8che	77	22	migration	migration	NN
cord-048466-fj9l8che	77	23	than	than	IN
cord-048466-fj9l8che	77	24	adaptive	adaptive	JJ
cord-048466-fj9l8che	77	25	evolution	evolution	NN
cord-048466-fj9l8che	77	26	of	of	IN
cord-048466-fj9l8che	77	27	the	the	DT
cord-048466-fj9l8che	77	28	genes	gene	NNS
cord-048466-fj9l8che	77	29	.	.	.
cord-048466-fj9l8che	78	1	A	a	DT
cord-048466-fj9l8che	78	2	constant	constant	JJ
cord-048466-fj9l8che	78	3	rate	rate	NN
cord-048466-fj9l8che	78	4	of	of	IN
cord-048466-fj9l8che	78	5	drift	drift	NN
cord-048466-fj9l8che	78	6	was	be	VBD
cord-048466-fj9l8che	78	7	not	not	RB
cord-048466-fj9l8che	78	8	observed	observe	VBN
cord-048466-fj9l8che	78	9	for	for	IN
cord-048466-fj9l8che	78	10	HA	HA	NNP
cord-048466-fj9l8che	79	1	but	but	CC
cord-048466-fj9l8che	79	2	instead	instead	RB
cord-048466-fj9l8che	79	3	periods	period	NNS
cord-048466-fj9l8che	79	4	of	of	IN
cord-048466-fj9l8che	79	5	change	change	NN
cord-048466-fj9l8che	79	6	followed	follow	VBN
cord-048466-fj9l8che	79	7	by	by	IN
cord-048466-fj9l8che	79	8	stasis	stasis	NN
cord-048466-fj9l8che	79	9	periods	period	NNS
cord-048466-fj9l8che	79	10	.	.	.
cord-048466-fj9l8che	80	1	The	the	DT
cord-048466-fj9l8che	80	2	low	low	JJ
cord-048466-fj9l8che	80	3	dN	dN	NNP
cord-048466-fj9l8che	80	4	/	/	SYM
cord-048466-fj9l8che	80	5	dS	d	NNS
cord-048466-fj9l8che	80	6	ratios	ratio	NNS
cord-048466-fj9l8che	80	7	(	(	-LRB-
cord-048466-fj9l8che	80	8	0.232	0.232	CD
cord-048466-fj9l8che	80	9	for	for	IN
cord-048466-fj9l8che	80	10	HA	HA	NNP
cord-048466-fj9l8che	80	11	and	and	CC
cord-048466-fj9l8che	80	12	0.247	0.247	CD
cord-048466-fj9l8che	80	13	for	for	IN
cord-048466-fj9l8che	80	14	NA	NA	NNP
cord-048466-fj9l8che	80	15	)	)	-RRB-
cord-048466-fj9l8che	80	16	also	also	RB
cord-048466-fj9l8che	80	17	indicated	indicate	VBD
cord-048466-fj9l8che	80	18	that	that	IN
cord-048466-fj9l8che	80	19	the	the	DT
cord-048466-fj9l8che	80	20	influenza	influenza	NN
cord-048466-fj9l8che	80	21	genes	gene	NNS
cord-048466-fj9l8che	80	22	were	be	VBD
cord-048466-fj9l8che	80	23	not	not	RB
cord-048466-fj9l8che	80	24	directly	directly	RB
cord-048466-fj9l8che	80	25	influenced	influence	VBN
cord-048466-fj9l8che	80	26	by	by	IN
cord-048466-fj9l8che	80	27	positive	positive	JJ
cord-048466-fj9l8che	80	28	selection	selection	NN
cord-048466-fj9l8che	80	29	.	.	.
cord-048466-fj9l8che	81	1	Reassortments	reassortment	NNS
cord-048466-fj9l8che	81	2	between	between	IN
cord-048466-fj9l8che	81	3	co	co	NN
cord-048466-fj9l8che	81	4	-	-	JJ
cord-048466-fj9l8che	81	5	circulating	circulating	JJ
cord-048466-fj9l8che	81	6	strains	strain	NNS
cord-048466-fj9l8che	81	7	and	and	CC
cord-048466-fj9l8che	81	8	viruses	virus	NNS
cord-048466-fj9l8che	81	9	from	from	IN
cord-048466-fj9l8che	81	10	previous	previous	JJ
cord-048466-fj9l8che	81	11	seasons	season	NNS
cord-048466-fj9l8che	81	12	,	,	,
cord-048466-fj9l8che	81	13	and	and	CC
cord-048466-fj9l8che	81	14	introduction	introduction	NN
cord-048466-fj9l8che	81	15	of	of	IN
cord-048466-fj9l8che	81	16	viruses	virus	NNS
cord-048466-fj9l8che	81	17	from	from	IN
cord-048466-fj9l8che	81	18	other	other	JJ
cord-048466-fj9l8che	81	19	parts	part	NNS
cord-048466-fj9l8che	81	20	of	of	IN
cord-048466-fj9l8che	81	21	the	the	DT
cord-048466-fj9l8che	81	22	world	world	NN
cord-048466-fj9l8che	81	23	might	may	MD
cord-048466-fj9l8che	81	24	play	play	VB
cord-048466-fj9l8che	81	25	a	a	DT
cord-048466-fj9l8che	81	26	larger	large	JJR
cord-048466-fj9l8che	81	27	role	role	NN
cord-048466-fj9l8che	81	28	than	than	IN
cord-048466-fj9l8che	81	29	natural	natural	JJ
cord-048466-fj9l8che	81	30	selection	selection	NN
cord-048466-fj9l8che	81	31	for	for	IN
cord-048466-fj9l8che	81	32	some	some	DT
cord-048466-fj9l8che	81	33	seasons	season	NNS
cord-048466-fj9l8che	81	34	,	,	,
cord-048466-fj9l8che	81	35	as	as	IN
cord-048466-fj9l8che	81	36	also	also	RB
cord-048466-fj9l8che	81	37	observed	observe	VBN
cord-048466-fj9l8che	81	38	by	by	IN
cord-048466-fj9l8che	81	39	others	other	NNS
cord-048466-fj9l8che	81	40	[	[	-LRB-
cord-048466-fj9l8che	81	41	27	27	CD
cord-048466-fj9l8che	81	42	,	,	,
cord-048466-fj9l8che	81	43	28	28	CD
cord-048466-fj9l8che	81	44	]	]	-RRB-
cord-048466-fj9l8che	81	45	.	.	.
cord-048466-fj9l8che	82	1	[	[	-LRB-
cord-048466-fj9l8che	82	2	2	2	CD
cord-048466-fj9l8che	82	3	,	,	,
cord-048466-fj9l8che	82	4	4	4	CD
cord-048466-fj9l8che	82	5	,	,	,
cord-048466-fj9l8che	82	6	25	25	CD
cord-048466-fj9l8che	82	7	,	,	,
cord-048466-fj9l8che	82	8	26	26	CD
cord-048466-fj9l8che	82	9	]	]	-RRB-
cord-048466-fj9l8che	82	10	.	.	.
cord-048466-fj9l8che	83	1	The	the	DT
cord-048466-fj9l8che	83	2	reassorted	reassorted	JJ
cord-048466-fj9l8che	83	3	H1N2	H1N2	NNP
cord-048466-fj9l8che	83	4	viruses	virus	NNS
cord-048466-fj9l8che	83	5	possessed	possess	VBD
cord-048466-fj9l8che	83	6	only	only	RB
cord-048466-fj9l8che	83	7	the	the	DT
cord-048466-fj9l8che	83	8	HA	HA	NNP
cord-048466-fj9l8che	83	9	from	from	IN
cord-048466-fj9l8che	83	10	A	A	NNP
cord-048466-fj9l8che	83	11	/	/	SYM
cord-048466-fj9l8che	83	12	New	New	NNP
cord-048466-fj9l8che	83	13	Caldonia/20/	caldonia/20/	NN
cord-048466-fj9l8che	83	14	99(H1N1)-like	99(h1n1)-like	CD
cord-048466-fj9l8che	83	15	viruses	virus	NNS
cord-048466-fj9l8che	83	16	and	and	CC
cord-048466-fj9l8che	83	17	the	the	DT
cord-048466-fj9l8che	83	18	rest	rest	NN
cord-048466-fj9l8che	83	19	of	of	IN
cord-048466-fj9l8che	83	20	the	the	DT
cord-048466-fj9l8che	83	21	genome	genome	NN
cord-048466-fj9l8che	83	22	from	from	IN
cord-048466-fj9l8che	83	23	A/	A/	NNP
cord-048466-fj9l8che	83	24	Moscow/10/99(H3N2)-like	moscow/10/99(h3n2)-like	NN
cord-048466-fj9l8che	83	25	viruses	virus	NNS
cord-048466-fj9l8che	83	26	as	as	RB
cord-048466-fj9l8che	83	27	also	also	RB
cord-048466-fj9l8che	83	28	reported	report	VBN
cord-048466-fj9l8che	83	29	by	by	IN
cord-048466-fj9l8che	83	30	others	other	NNS
cord-048466-fj9l8che	83	31	using	use	VBG
cord-048466-fj9l8che	83	32	partial	partial	JJ
cord-048466-fj9l8che	83	33	sequences	sequence	NNS
cord-048466-fj9l8che	83	34	[	[	-LRB-
cord-048466-fj9l8che	83	35	25	25	CD
cord-048466-fj9l8che	83	36	]	]	-RRB-
cord-048466-fj9l8che	83	37	.	.	.
cord-048466-fj9l8che	84	1	The	the	DT
cord-048466-fj9l8che	84	2	H1N2	H1N2	NNP
cord-048466-fj9l8che	84	3	viruses	virus	NNS
cord-048466-fj9l8che	84	4	have	have	VBP
cord-048466-fj9l8che	84	5	been	be	VBN
cord-048466-fj9l8che	84	6	introduced	introduce	VBN
cord-048466-fj9l8che	84	7	to	to	IN
cord-048466-fj9l8che	84	8	Denmark	Denmark	NNP
cord-048466-fj9l8che	84	9	from	from	IN
cord-048466-fj9l8che	84	10	elsewhere	elsewhere	RB
cord-048466-fj9l8che	84	11	and	and	CC
cord-048466-fj9l8che	84	12	are	be	VBP
cord-048466-fj9l8che	84	13	not	not	RB
cord-048466-fj9l8che	84	14	a	a	DT
cord-048466-fj9l8che	84	15	local	local	JJ
cord-048466-fj9l8che	84	16	reassortant	reassortant	NN
cord-048466-fj9l8che	84	17	.	.	.
cord-048466-fj9l8che	85	1	(	(	-LRB-
cord-048466-fj9l8che	85	2	Table	table	NN
cord-048466-fj9l8che	85	3	1	1	CD
cord-048466-fj9l8che	85	4	)	)	-RRB-
cord-048466-fj9l8che	85	5	suggesting	suggest	VBG
cord-048466-fj9l8che	85	6	they	-PRON-	PRP
cord-048466-fj9l8che	85	7	may	may	MD
cord-048466-fj9l8che	85	8	be	be	VB
cord-048466-fj9l8che	85	9	important	important	JJ
cord-048466-fj9l8che	85	10	for	for	IN
cord-048466-fj9l8che	85	11	viral	viral	JJ
cord-048466-fj9l8che	85	12	escape	escape	NN
cord-048466-fj9l8che	85	13	from	from	IN
cord-048466-fj9l8che	85	14	the	the	DT
cord-048466-fj9l8che	85	15	host	host	NN
cord-048466-fj9l8che	85	16	immune	immune	JJ
cord-048466-fj9l8che	85	17	system	system	NN
cord-048466-fj9l8che	85	18	and	and	CC
cord-048466-fj9l8che	85	19	the	the	DT
cord-048466-fj9l8che	85	20	overall	overall	JJ
cord-048466-fj9l8che	85	21	fit	fit	NN
cord-048466-fj9l8che	85	22	of	of	IN
cord-048466-fj9l8che	85	23	the	the	DT
cord-048466-fj9l8che	85	24	virus	virus	NN
cord-048466-fj9l8che	85	25	.	.	.
cord-048466-fj9l8che	86	1	The	the	DT
cord-048466-fj9l8che	86	2	A	A	NNP
cord-048466-fj9l8che	86	3	/	/	SYM
cord-048466-fj9l8che	86	4	Fujian/411/02-like(H3N2	fujian/411/02-like(h3n2	CD
cord-048466-fj9l8che	86	5	)	)	-RRB-
cord-048466-fj9l8che	86	6	viruses	virus	NNS
cord-048466-fj9l8che	86	7	did	do	VBD
cord-048466-fj9l8che	86	8	not	not	RB
cord-048466-fj9l8che	86	9	antigenically	antigenically	RB
cord-048466-fj9l8che	86	10	match	match	VB
cord-048466-fj9l8che	86	11	the	the	DT
cord-048466-fj9l8che	86	12	A	A	NNP
cord-048466-fj9l8che	86	13	/	/	SYM
cord-048466-fj9l8che	86	14	Moscow/10/99(H3N2	Moscow/10/99(H3N2	NNP
cord-048466-fj9l8che	86	15	)	)	-RRB-
cord-048466-fj9l8che	86	16	strain	strain	NN
cord-048466-fj9l8che	86	17	included	include	VBN
cord-048466-fj9l8che	86	18	in	in	IN
cord-048466-fj9l8che	86	19	the	the	DT
cord-048466-fj9l8che	86	20	2002	2002	CD
cord-048466-fj9l8che	86	21	-	-	SYM
cord-048466-fj9l8che	86	22	2003	2003	CD
cord-048466-fj9l8che	86	23	vaccine	vaccine	NN
cord-048466-fj9l8che	86	24	[	[	-LRB-
cord-048466-fj9l8che	86	25	29	29	CD
cord-048466-fj9l8che	86	26	,	,	,
cord-048466-fj9l8che	86	27	36	36	CD
cord-048466-fj9l8che	86	28	]	]	-RRB-
cord-048466-fj9l8che	86	29	.	.	.
cord-048466-fj9l8che	87	1	The	the	DT
cord-048466-fj9l8che	87	2	HA	HA	NNP
cord-048466-fj9l8che	87	3	substitution	substitution	NN
cord-048466-fj9l8che	87	4	D144N	d144n	NN
cord-048466-fj9l8che	87	5	was	be	VBD
cord-048466-fj9l8che	87	6	however	however	RB
cord-048466-fj9l8che	87	7	not	not	RB
cord-048466-fj9l8che	87	8	responsible	responsible	JJ
cord-048466-fj9l8che	87	9	for	for	IN
cord-048466-fj9l8che	87	10	the	the	DT
cord-048466-fj9l8che	87	11	antigenic	antigenic	JJ
cord-048466-fj9l8che	87	12	drift	drift	NN
cord-048466-fj9l8che	87	13	of	of	IN
cord-048466-fj9l8che	87	14	the	the	DT
cord-048466-fj9l8che	87	15	Fujian	Fujian	NNP
cord-048466-fj9l8che	87	16	-	-	HYPH
cord-048466-fj9l8che	87	17	like	like	JJ
cord-048466-fj9l8che	87	18	viruses	virus	NNS
cord-048466-fj9l8che	87	19	.	.	.
cord-048466-fj9l8che	88	1	It	-PRON-	PRP
cord-048466-fj9l8che	88	2	has	have	VBZ
cord-048466-fj9l8che	88	3	been	be	VBN
cord-048466-fj9l8che	88	4	shown	show	VBN
cord-048466-fj9l8che	88	5	that	that	IN
cord-048466-fj9l8che	88	6	only	only	RB
cord-048466-fj9l8che	88	7	two	two	CD
cord-048466-fj9l8che	88	8	amino	amino	NN
cord-048466-fj9l8che	88	9	acid	acid	NN
cord-048466-fj9l8che	88	10	changes	change	NNS
cord-048466-fj9l8che	88	11	,	,	,
cord-048466-fj9l8che	88	12	H155	H155	''
cord-048466-fj9l8che	88	13	T	T	NNP
cord-048466-fj9l8che	88	14	and	and	CC
cord-048466-fj9l8che	88	15	Q156H	Q156H	NNP
cord-048466-fj9l8che	88	16	,	,	,
cord-048466-fj9l8che	88	17	specified	specify	VBD
cord-048466-fj9l8che	88	18	the	the	DT
cord-048466-fj9l8che	88	19	antigenic	antigenic	JJ
cord-048466-fj9l8che	88	20	difference	difference	NN
cord-048466-fj9l8che	88	21	from	from	IN
cord-048466-fj9l8che	88	22	Moscow	Moscow	NNP
cord-048466-fj9l8che	88	23	-	-	HYPH
cord-048466-fj9l8che	88	24	like	like	JJ
cord-048466-fj9l8che	88	25	to	to	IN
cord-048466-fj9l8che	88	26	Fujian	Fujian	NNP
cord-048466-fj9l8che	88	27	-	-	HYPH
cord-048466-fj9l8che	88	28	like	like	JJ
cord-048466-fj9l8che	88	29	[	[	-LRB-
cord-048466-fj9l8che	88	30	37	37	CD
cord-048466-fj9l8che	88	31	]	]	-RRB-
cord-048466-fj9l8che	88	32	,	,	,
cord-048466-fj9l8che	88	33	both	both	DT
cord-048466-fj9l8che	88	34	are	be	VBP
cord-048466-fj9l8che	88	35	located	locate	VBN
cord-048466-fj9l8che	88	36	at	at	IN
cord-048466-fj9l8che	88	37	antigenic	antigenic	JJ
cord-048466-fj9l8che	88	38	site	site	NN
cord-048466-fj9l8che	88	39	B.	B.	NNP
cord-048466-fj9l8che	89	1	The	the	DT
cord-048466-fj9l8che	89	2	T155	T155	NNP
cord-048466-fj9l8che	89	3	and	and	CC
cord-048466-fj9l8che	89	4	H156	h156	CD
cord-048466-fj9l8che	89	5	amino	amino	NN
cord-048466-fj9l8che	89	6	acids	acid	NNS
cord-048466-fj9l8che	89	7	have	have	VBP
cord-048466-fj9l8che	89	8	been	be	VBN
cord-048466-fj9l8che	89	9	maintained	maintain	VBN
cord-048466-fj9l8che	89	10	in	in	IN
cord-048466-fj9l8che	89	11	all	all	DT
cord-048466-fj9l8che	89	12	Danish	danish	JJ
cord-048466-fj9l8che	89	13	isolates	isolate	NNS
cord-048466-fj9l8che	89	14	after	after	IN
cord-048466-fj9l8che	89	15	the	the	DT
cord-048466-fj9l8che	89	16	introduction	introduction	NN
cord-048466-fj9l8che	89	17	of	of	IN
cord-048466-fj9l8che	89	18	the	the	DT
cord-048466-fj9l8che	89	19	Fujian	Fujian	NNP
cord-048466-fj9l8che	89	20	-	-	HYPH
cord-048466-fj9l8che	89	21	like	like	JJ
cord-048466-fj9l8che	89	22	viruses	virus	NNS
cord-048466-fj9l8che	89	23	.	.	.
cord-048466-fj9l8che	90	1	With	with	IN
cord-048466-fj9l8che	90	2	the	the	DT
cord-048466-fj9l8che	90	3	A	A	NNP
cord-048466-fj9l8che	90	4	/	/	SYM
cord-048466-fj9l8che	90	5	California/7/04(H3N2)-like	California/7/04(H3N2)-like	NNP
cord-048466-fj9l8che	90	6	viruses	virus	NNS
cord-048466-fj9l8che	90	7	in	in	IN
cord-048466-fj9l8che	90	8	2004	2004	CD
cord-048466-fj9l8che	90	9	-	-	SYM
cord-048466-fj9l8che	90	10	2005	2005	CD
cord-048466-fj9l8che	90	11	,	,	,
cord-048466-fj9l8che	90	12	site	site	NN
cord-048466-fj9l8che	90	13	145	145	CD
cord-048466-fj9l8che	90	14	has	have	VBZ
cord-048466-fj9l8che	90	15	changed	change	VBN
cord-048466-fj9l8che	90	16	from	from	IN
cord-048466-fj9l8che	90	17	K	K	NNP
cord-048466-fj9l8che	90	18	to	to	IN
cord-048466-fj9l8che	90	19	S	s	NN
cord-048466-fj9l8che	90	20	in	in	IN
cord-048466-fj9l8che	90	21	some	some	DT
cord-048466-fj9l8che	90	22	isolates	isolate	NNS
cord-048466-fj9l8che	90	23	and	and	CC
cord-048466-fj9l8che	90	24	to	to	IN
cord-048466-fj9l8che	90	25	N	n	CD
cord-048466-fj9l8che	90	26	in	in	IN
cord-048466-fj9l8che	90	27	others	other	NNS
cord-048466-fj9l8che	90	28	.	.	.
cord-048466-fj9l8che	91	1	S145	S145	NNP
cord-048466-fj9l8che	91	2	has	have	VBZ
cord-048466-fj9l8che	91	3	been	be	VBN
cord-048466-fj9l8che	91	4	found	find	VBN
cord-048466-fj9l8che	91	5	at	at	IN
cord-048466-fj9l8che	91	6	this	this	DT
cord-048466-fj9l8che	91	7	position	position	NN
cord-048466-fj9l8che	91	8	before	before	IN
cord-048466-fj9l8che	91	9	1999	1999	CD
cord-048466-fj9l8che	91	10	and	and	CC
cord-048466-fj9l8che	91	11	N145	N145	NNP
cord-048466-fj9l8che	91	12	K	K	NNP
cord-048466-fj9l8che	91	13	was	be	VBD
cord-048466-fj9l8che	91	14	the	the	DT
cord-048466-fj9l8che	91	15	only	only	JJ
cord-048466-fj9l8che	91	16	cluster	cluster	NN
cord-048466-fj9l8che	91	17	-	-	HYPH
cord-048466-fj9l8che	91	18	difference	difference	NN
cord-048466-fj9l8che	91	19	substitution	substitution	NN
cord-048466-fj9l8che	91	20	between	between	IN
cord-048466-fj9l8che	91	21	isolates	isolate	NNS
cord-048466-fj9l8che	91	22	from	from	IN
cord-048466-fj9l8che	91	23	the	the	DT
cord-048466-fj9l8che	91	24	seasons	season	NNS
cord-048466-fj9l8che	91	25	1987/	1987/	CD
cord-048466-fj9l8che	91	26	1989	1989	CD
cord-048466-fj9l8che	91	27	and	and	CC
cord-048466-fj9l8che	91	28	1992/1995	1992/1995	CD
cord-048466-fj9l8che	91	29	[	[	-LRB-
cord-048466-fj9l8che	91	30	38	38	CD
cord-048466-fj9l8che	91	31	]	]	-RRB-
cord-048466-fj9l8che	91	32	.	.	.
cord-048466-fj9l8che	92	1	It	-PRON-	PRP
cord-048466-fj9l8che	92	2	was	be	VBD
cord-048466-fj9l8che	92	3	therefore	therefore	RB
cord-048466-fj9l8che	92	4	suggested	suggest	VBN
cord-048466-fj9l8che	92	5	that	that	IN
cord-048466-fj9l8che	92	6	substitutions	substitution	NNS
cord-048466-fj9l8che	92	7	at	at	IN
cord-048466-fj9l8che	92	8	this	this	DT
cord-048466-fj9l8che	92	9	site	site	NN
cord-048466-fj9l8che	92	10	alone	alone	RB
cord-048466-fj9l8che	92	11	could	could	MD
cord-048466-fj9l8che	92	12	have	have	VB
cord-048466-fj9l8che	92	13	large	large	JJ
cord-048466-fj9l8che	92	14	antigenic	antigenic	JJ
cord-048466-fj9l8che	92	15	effect	effect	NN
cord-048466-fj9l8che	92	16	.	.	.
cord-048466-fj9l8che	93	1	Antigenic	antigenic	JJ
cord-048466-fj9l8che	93	2	site	site	NN
cord-048466-fj9l8che	93	3	A	a	NN
cord-048466-fj9l8che	93	4	,	,	,
cord-048466-fj9l8che	93	5	located	locate	VBN
cord-048466-fj9l8che	93	6	in	in	IN
cord-048466-fj9l8che	93	7	a	a	DT
cord-048466-fj9l8che	93	8	loop	loop	NN
cord-048466-fj9l8che	93	9	,	,	,
cord-048466-fj9l8che	93	10	makes	make	VBZ
cord-048466-fj9l8che	93	11	few	few	JJ
cord-048466-fj9l8che	93	12	contacts	contact	NNS
cord-048466-fj9l8che	93	13	with	with	IN
cord-048466-fj9l8che	93	14	the	the	DT
cord-048466-fj9l8che	93	15	rest	rest	NN
cord-048466-fj9l8che	93	16	of	of	IN
cord-048466-fj9l8che	93	17	the	the	DT
cord-048466-fj9l8che	93	18	structure	structure	NN
cord-048466-fj9l8che	93	19	,	,	,
cord-048466-fj9l8che	93	20	therefore	therefore	RB
cord-048466-fj9l8che	93	21	144	144	CD
cord-048466-fj9l8che	93	22	and	and	CC
cord-048466-fj9l8che	93	23	145	145	CD
cord-048466-fj9l8che	93	24	may	may	MD
cord-048466-fj9l8che	93	25	change	change	VB
cord-048466-fj9l8che	93	26	drastically	drastically	RB
cord-048466-fj9l8che	93	27	without	without	IN
cord-048466-fj9l8che	93	28	influencing	influence	VBG
cord-048466-fj9l8che	93	29	on	on	IN
cord-048466-fj9l8che	93	30	the	the	DT
cord-048466-fj9l8che	93	31	overall	overall	JJ
cord-048466-fj9l8che	93	32	shape	shape	NN
cord-048466-fj9l8che	93	33	of	of	IN
cord-048466-fj9l8che	93	34	the	the	DT
cord-048466-fj9l8che	93	35	HA	HA	NNP
cord-048466-fj9l8che	93	36	molecule	molecule	NN
cord-048466-fj9l8che	93	37	.	.	.
cord-048466-fj9l8che	94	1	Antigenic	antigenic	JJ
cord-048466-fj9l8che	94	2	site	site	NN
cord-048466-fj9l8che	94	3	A	a	NN
cord-048466-fj9l8che	94	4	is	be	VBZ
cord-048466-fj9l8che	94	5	supposed	suppose	VBN
cord-048466-fj9l8che	94	6	to	to	TO
cord-048466-fj9l8che	94	7	be	be	VB
cord-048466-fj9l8che	94	8	ideal	ideal	JJ
cord-048466-fj9l8che	94	9	for	for	IN
cord-048466-fj9l8che	94	10	antibody	antibody	NN
cord-048466-fj9l8che	94	11	binding	binding	NN
cord-048466-fj9l8che	94	12	and	and	CC
cord-048466-fj9l8che	94	13	for	for	IN
cord-048466-fj9l8che	94	14	amino	amino	NN
cord-048466-fj9l8che	94	15	acid	acid	NN
cord-048466-fj9l8che	94	16	replacements	replacement	NNS
cord-048466-fj9l8che	94	17	[	[	-LRB-
cord-048466-fj9l8che	94	18	33	33	CD
cord-048466-fj9l8che	94	19	]	]	-RRB-
cord-048466-fj9l8che	94	20	.	.	.
cord-048466-fj9l8che	95	1	The	the	DT
cord-048466-fj9l8che	95	2	preferred	preferred	JJ
cord-048466-fj9l8che	95	3	antigenic	antigenic	JJ
cord-048466-fj9l8che	95	4	site	site	NN
cord-048466-fj9l8che	95	5	in	in	IN
cord-048466-fj9l8che	95	6	the	the	DT
cord-048466-fj9l8che	95	7	change	change	NN
cord-048466-fj9l8che	95	8	from	from	IN
cord-048466-fj9l8che	95	9	A	a	NN
cord-048466-fj9l8che	95	10	/	/	SYM
cord-048466-fj9l8che	95	11	Moscow/10/	Moscow/10/	VBZ
cord-048466-fj9l8che	95	12	99(H3N2	99(h3n2	LS
cord-048466-fj9l8che	95	13	)	)	-RRB-
cord-048466-fj9l8che	95	14	to	to	IN
cord-048466-fj9l8che	95	15	A	a	DT
cord-048466-fj9l8che	95	16	/	/	SYM
cord-048466-fj9l8che	95	17	Fujian/411/02(H3N2)-like	Fujian/411/02(H3N2)-like	NNP
cord-048466-fj9l8che	95	18	viruses	virus	NNS
cord-048466-fj9l8che	95	19	was	be	VBD
cord-048466-fj9l8che	95	20	site	site	NN
cord-048466-fj9l8che	95	21	B.	B.	NNP
cord-048466-fj9l8che	96	1	This	this	DT
cord-048466-fj9l8che	96	2	observation	observation	NN
cord-048466-fj9l8che	96	3	is	be	VBZ
cord-048466-fj9l8che	96	4	in	in	IN
cord-048466-fj9l8che	96	5	accordance	accordance	NN
cord-048466-fj9l8che	96	6	with	with	IN
cord-048466-fj9l8che	96	7	previously	previously	RB
cord-048466-fj9l8che	96	8	published	publish	VBN
cord-048466-fj9l8che	96	9	data	datum	NNS
cord-048466-fj9l8che	96	10	[	[	-LRB-
cord-048466-fj9l8che	96	11	39	39	CD
cord-048466-fj9l8che	96	12	]	]	-RRB-
cord-048466-fj9l8che	96	13	.	.	.
cord-048466-fj9l8che	97	1	One	one	CD
cord-048466-fj9l8che	97	2	region	region	NN
cord-048466-fj9l8che	97	3	in	in	IN
cord-048466-fj9l8che	97	4	HA	HA	NNP
cord-048466-fj9l8che	97	5	,	,	,
cord-048466-fj9l8che	97	6	position	position	VB
cord-048466-fj9l8che	97	7	225	225	CD
cord-048466-fj9l8che	97	8	to	to	IN
cord-048466-fj9l8che	97	9	227	227	CD
cord-048466-fj9l8che	97	10	,	,	,
cord-048466-fj9l8che	97	11	that	that	DT
cord-048466-fj9l8che	97	12	influence	influence	VBP
cord-048466-fj9l8che	97	13	antigenic	antigenic	JJ
cord-048466-fj9l8che	97	14	site	site	NN
cord-048466-fj9l8che	97	15	D	d	NN
cord-048466-fj9l8che	97	16	,	,	,
cord-048466-fj9l8che	97	17	has	have	VBZ
cord-048466-fj9l8che	97	18	changed	change	VBN
cord-048466-fj9l8che	97	19	drastically	drastically	RB
cord-048466-fj9l8che	97	20	during	during	IN
cord-048466-fj9l8che	97	21	the	the	DT
cord-048466-fj9l8che	97	22	study	study	NN
cord-048466-fj9l8che	97	23	period	period	NN
cord-048466-fj9l8che	97	24	from	from	IN
cord-048466-fj9l8che	97	25	GVS	GVS	NNP
cord-048466-fj9l8che	97	26	→	→	SYM
cord-048466-fj9l8che	97	27	DVS	DVS	NNP
cord-048466-fj9l8che	97	28	→	→	SYM
cord-048466-fj9l8che	97	29	DIP	dip	NN
cord-048466-fj9l8che	97	30	→	→	WDT
cord-048466-fj9l8che	97	31	NIP	nip	NN
cord-048466-fj9l8che	97	32	.	.	.
cord-048466-fj9l8che	98	1	The	the	DT
cord-048466-fj9l8che	98	2	influence	influence	NN
cord-048466-fj9l8che	98	3	of	of	IN
cord-048466-fj9l8che	98	4	antigenic	antigenic	JJ
cord-048466-fj9l8che	98	5	site	site	NN
cord-048466-fj9l8che	98	6	D	D	NNP
cord-048466-fj9l8che	98	7	was	be	VBD
cord-048466-fj9l8che	98	8	first	first	RB
cord-048466-fj9l8che	98	9	apparent	apparent	JJ
cord-048466-fj9l8che	98	10	in	in	IN
cord-048466-fj9l8che	98	11	the	the	DT
cord-048466-fj9l8che	98	12	antigenic	antigenic	JJ
cord-048466-fj9l8che	98	13	change	change	NN
cord-048466-fj9l8che	98	14	from	from	IN
cord-048466-fj9l8che	98	15	Fujian	Fujian	NNP
cord-048466-fj9l8che	98	16	-	-	HYPH
cord-048466-fj9l8che	98	17	like	like	JJ
cord-048466-fj9l8che	98	18	viruses	virus	NNS
cord-048466-fj9l8che	98	19	to	to	IN
cord-048466-fj9l8che	98	20	California	California	NNP
cord-048466-fj9l8che	98	21	-	-	HYPH
cord-048466-fj9l8che	98	22	like	like	JJ
cord-048466-fj9l8che	98	23	viruses	virus	NNS
cord-048466-fj9l8che	98	24	;	;	:
cord-048466-fj9l8che	98	25	however	however	RB
cord-048466-fj9l8che	98	26	,	,	,
cord-048466-fj9l8che	98	27	the	the	DT
cord-048466-fj9l8che	98	28	antigenic	antigenic	JJ
cord-048466-fj9l8che	98	29	site	site	NN
cord-048466-fj9l8che	98	30	B	B	NNP
cord-048466-fj9l8che	98	31	was	be	VBD
cord-048466-fj9l8che	98	32	still	still	RB
cord-048466-fj9l8che	98	33	the	the	DT
cord-048466-fj9l8che	98	34	preferred	preferred	JJ
cord-048466-fj9l8che	98	35	site	site	NN
cord-048466-fj9l8che	98	36	for	for	IN
cord-048466-fj9l8che	98	37	antigenic	antigenic	JJ
cord-048466-fj9l8che	98	38	change	change	NN
cord-048466-fj9l8che	98	39	.	.	.
cord-048466-fj9l8che	99	1	It	-PRON-	PRP
cord-048466-fj9l8che	99	2	has	have	VBZ
cord-048466-fj9l8che	99	3	been	be	VBN
cord-048466-fj9l8che	99	4	proposed	propose	VBN
cord-048466-fj9l8che	99	5	that	that	IN
cord-048466-fj9l8che	99	6	a	a	DT
cord-048466-fj9l8che	99	7	minimum	minimum	NN
cord-048466-fj9l8che	99	8	of	of	IN
cord-048466-fj9l8che	99	9	four	four	CD
cord-048466-fj9l8che	99	10	substitutions	substitution	NNS
cord-048466-fj9l8che	99	11	in	in	IN
cord-048466-fj9l8che	99	12	two	two	CD
cord-048466-fj9l8che	99	13	or	or	CC
cord-048466-fj9l8che	99	14	more	more	JJR
cord-048466-fj9l8che	99	15	antibody	antibody	NN
cord-048466-fj9l8che	99	16	binding	bind	VBG
cord-048466-fj9l8che	99	17	sites	site	NNS
cord-048466-fj9l8che	99	18	are	be	VBP
cord-048466-fj9l8che	99	19	required	require	VBN
cord-048466-fj9l8che	99	20	for	for	IN
cord-048466-fj9l8che	99	21	an	an	DT
cord-048466-fj9l8che	99	22	epidemically	epidemically	RB
cord-048466-fj9l8che	99	23	important	important	JJ
cord-048466-fj9l8che	99	24	strain	strain	NN
cord-048466-fj9l8che	99	25	[	[	-LRB-
cord-048466-fj9l8che	99	26	40	40	CD
cord-048466-fj9l8che	99	27	]	]	-RRB-
cord-048466-fj9l8che	99	28	.	.	.
cord-048466-fj9l8che	99	29	 	 	_SP
cord-048466-fj9l8che	100	1	Gulati	Gulati	NNP
cord-048466-fj9l8che	100	2	et	et	NNP
cord-048466-fj9l8che	100	3	al	al	NNP
cord-048466-fj9l8che	100	4	.	.	.
cord-048466-fj9l8che	101	1	,	,	,
cord-048466-fj9l8che	101	2	[	[	-LRB-
cord-048466-fj9l8che	101	3	41	41	CD
cord-048466-fj9l8che	101	4	]	]	-RRB-
cord-048466-fj9l8che	102	1	[	[	-LRB-
cord-048466-fj9l8che	102	2	22	22	CD
cord-048466-fj9l8che	102	3	,	,	,
cord-048466-fj9l8che	102	4	[	[	-LRB-
cord-048466-fj9l8che	102	5	42	42	CD
cord-048466-fj9l8che	102	6	]	]	-RRB-
cord-048466-fj9l8che	102	7	[	[	-LRB-
cord-048466-fj9l8che	102	8	43	43	CD
cord-048466-fj9l8che	102	9	]	]	-RRB-
cord-048466-fj9l8che	102	10	[	[	-LRB-
cord-048466-fj9l8che	102	11	44	44	CD
cord-048466-fj9l8che	102	12	]	]	-RRB-
cord-048466-fj9l8che	102	13	[	[	-LRB-
cord-048466-fj9l8che	102	14	45	45	CD
cord-048466-fj9l8che	102	15	]	]	-RRB-
cord-048466-fj9l8che	102	16	.	.	.
cord-048466-fj9l8che	103	1	The	the	DT
cord-048466-fj9l8che	103	2	substitution	substitution	NN
cord-048466-fj9l8che	103	3	H274Y	h274y	NN
cord-048466-fj9l8che	103	4	is	be	VBZ
cord-048466-fj9l8che	103	5	the	the	DT
cord-048466-fj9l8che	103	6	only	only	JJ
cord-048466-fj9l8che	103	7	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	103	8	resistance	resistance	NN
cord-048466-fj9l8che	103	9	mutation	mutation	NN
cord-048466-fj9l8che	103	10	identified	identify	VBN
cord-048466-fj9l8che	103	11	in	in	IN
cord-048466-fj9l8che	103	12	H1N1	H1N1	NNP
cord-048466-fj9l8che	103	13	viruses	virus	NNS
cord-048466-fj9l8che	103	14	to	to	IN
cord-048466-fj9l8che	103	15	date	date	NN
cord-048466-fj9l8che	103	16	[	[	-LRB-
cord-048466-fj9l8che	103	17	46	46	CD
cord-048466-fj9l8che	103	18	,	,	,
cord-048466-fj9l8che	103	19	47	47	CD
cord-048466-fj9l8che	103	20	]	]	-RRB-
cord-048466-fj9l8che	103	21	.	.	.
cord-048466-fj9l8che	104	1	Danish	danish	JJ
cord-048466-fj9l8che	104	2	isolates	isolate	NNS
cord-048466-fj9l8che	104	3	did	do	VBD
cord-048466-fj9l8che	104	4	not	not	RB
cord-048466-fj9l8che	104	5	possess	possess	VB
cord-048466-fj9l8che	104	6	any	any	DT
cord-048466-fj9l8che	104	7	resistance	resistance	NN
cord-048466-fj9l8che	104	8	mutations	mutation	NNS
cord-048466-fj9l8che	104	9	in	in	IN
cord-048466-fj9l8che	104	10	the	the	DT
cord-048466-fj9l8che	104	11	NAs	NAs	NNPS
cord-048466-fj9l8che	104	12	.	.	.
cord-048466-fj9l8che	105	1	Neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	105	2	inhibitory	inhibitory	JJ
cord-048466-fj9l8che	105	3	drugs	drug	NNS
cord-048466-fj9l8che	105	4	are	be	VBP
cord-048466-fj9l8che	105	5	rarely	rarely	RB
cord-048466-fj9l8che	105	6	used	use	VBN
cord-048466-fj9l8che	105	7	for	for	IN
cord-048466-fj9l8che	105	8	influenza	influenza	NN
cord-048466-fj9l8che	105	9	prophylaxis	prophylaxis	NN
cord-048466-fj9l8che	105	10	or	or	CC
cord-048466-fj9l8che	105	11	treatment	treatment	NN
cord-048466-fj9l8che	105	12	in	in	IN
cord-048466-fj9l8che	105	13	Denmark	Denmark	NNP
cord-048466-fj9l8che	105	14	.	.	.
cord-048466-fj9l8che	106	1	T	t	NN
cord-048466-fj9l8che	106	2	-	-	HYPH
cord-048466-fj9l8che	106	3	cell	cell	NN
cord-048466-fj9l8che	106	4	epitopes	epitope	NNS
cord-048466-fj9l8che	106	5	are	be	VBP
cord-048466-fj9l8che	106	6	more	more	RBR
cord-048466-fj9l8che	106	7	conserved	conserve	VBN
cord-048466-fj9l8che	106	8	than	than	IN
cord-048466-fj9l8che	106	9	antibody	antibody	NN
cord-048466-fj9l8che	106	10	epitopes	epitope	NNS
cord-048466-fj9l8che	106	11	.	.	.
cord-048466-fj9l8che	107	1	Fifteen	fifteen	CD
cord-048466-fj9l8che	107	2	per	per	IN
cord-048466-fj9l8che	107	3	cent	cent	NN
cord-048466-fj9l8che	107	4	of	of	IN
cord-048466-fj9l8che	107	5	the	the	DT
cord-048466-fj9l8che	107	6	T	t	NN
cord-048466-fj9l8che	107	7	-	-	HYPH
cord-048466-fj9l8che	107	8	cell	cell	NN
cord-048466-fj9l8che	107	9	epitopes	epitope	NNS
cord-048466-fj9l8che	107	10	are	be	VBP
cord-048466-fj9l8che	107	11	conserved	conserve	VBN
cord-048466-fj9l8che	107	12	while	while	IN
cord-048466-fj9l8che	107	13	only	only	RB
cord-048466-fj9l8che	107	14	2.7	2.7	CD
cord-048466-fj9l8che	107	15	%	%	NN
cord-048466-fj9l8che	107	16	of	of	IN
cord-048466-fj9l8che	107	17	the	the	DT
cord-048466-fj9l8che	107	18	antibody	antibody	NN
cord-048466-fj9l8che	107	19	epitopes	epitope	NNS
cord-048466-fj9l8che	107	20	[	[	-LRB-
cord-048466-fj9l8che	107	21	48	48	CD
cord-048466-fj9l8che	107	22	]	]	-RRB-
cord-048466-fj9l8che	107	23	.	.	.
cord-048466-fj9l8che	108	1	The	the	DT
cord-048466-fj9l8che	108	2	reason	reason	NN
cord-048466-fj9l8che	108	3	for	for	IN
cord-048466-fj9l8che	108	4	this	this	DT
cord-048466-fj9l8che	108	5	higher	high	JJR
cord-048466-fj9l8che	108	6	degree	degree	NN
cord-048466-fj9l8che	108	7	of	of	IN
cord-048466-fj9l8che	108	8	conservation	conservation	NN
cord-048466-fj9l8che	108	9	is	be	VBZ
cord-048466-fj9l8che	108	10	that	that	IN
cord-048466-fj9l8che	108	11	80	80	CD
cord-048466-fj9l8che	108	12	%	%	NN
cord-048466-fj9l8che	108	13	of	of	IN
cord-048466-fj9l8che	108	14	the	the	DT
cord-048466-fj9l8che	108	15	antibody	antibody	NN
cord-048466-fj9l8che	108	16	epitopes	epitope	NNS
cord-048466-fj9l8che	108	17	are	be	VBP
cord-048466-fj9l8che	108	18	located	locate	VBN
cord-048466-fj9l8che	108	19	in	in	IN
cord-048466-fj9l8che	108	20	the	the	DT
cord-048466-fj9l8che	108	21	variable	variable	JJ
cord-048466-fj9l8che	108	22	glycoproteins	glycoprotein	NNS
cord-048466-fj9l8che	108	23	HA	HA	NNP
cord-048466-fj9l8che	108	24	and	and	CC
cord-048466-fj9l8che	108	25	NA	NA	NNP
cord-048466-fj9l8che	108	26	,	,	,
cord-048466-fj9l8che	108	27	while	while	IN
cord-048466-fj9l8che	108	28	only	only	RB
cord-048466-fj9l8che	108	29	40	40	CD
cord-048466-fj9l8che	108	30	%	%	NN
cord-048466-fj9l8che	108	31	of	of	IN
cord-048466-fj9l8che	108	32	the	the	DT
cord-048466-fj9l8che	108	33	T	t	NN
cord-048466-fj9l8che	108	34	-	-	HYPH
cord-048466-fj9l8che	108	35	cell	cell	NN
cord-048466-fj9l8che	108	36	epitopes	epitope	NNS
cord-048466-fj9l8che	108	37	are	be	VBP
cord-048466-fj9l8che	108	38	found	find	VBN
cord-048466-fj9l8che	108	39	in	in	IN
cord-048466-fj9l8che	108	40	these	these	DT
cord-048466-fj9l8che	108	41	proteins	protein	NNS
cord-048466-fj9l8che	108	42	[	[	-LRB-
cord-048466-fj9l8che	108	43	48	48	CD
cord-048466-fj9l8che	108	44	]	]	-RRB-
cord-048466-fj9l8che	108	45	.	.	.
cord-048466-fj9l8che	109	1	Recent	recent	JJ
cord-048466-fj9l8che	109	2	research	research	NN
cord-048466-fj9l8che	109	3	has	have	VBZ
cord-048466-fj9l8che	109	4	shown	show	VBN
cord-048466-fj9l8che	109	5	some	some	DT
cord-048466-fj9l8che	109	6	degree	degree	NN
cord-048466-fj9l8che	109	7	of	of	IN
cord-048466-fj9l8che	109	8	escape	escape	NN
cord-048466-fj9l8che	109	9	from	from	IN
cord-048466-fj9l8che	109	10	CTL	CTL	NNP
cord-048466-fj9l8che	109	11	-	-	HYPH
cord-048466-fj9l8che	109	12	mediated	mediate	VBN
cord-048466-fj9l8che	109	13	immunity	immunity	NN
cord-048466-fj9l8che	109	14	in	in	IN
cord-048466-fj9l8che	109	15	addition	addition	NN
cord-048466-fj9l8che	109	16	to	to	TO
cord-048466-fj9l8che	109	17	escape	escape	VB
cord-048466-fj9l8che	109	18	from	from	IN
cord-048466-fj9l8che	109	19	neutralizing	neutralize	VBG
cord-048466-fj9l8che	109	20	antibodies	antibody	NNS
cord-048466-fj9l8che	109	21	[	[	-LRB-
cord-048466-fj9l8che	109	22	28	28	CD
cord-048466-fj9l8che	109	23	]	]	-RRB-
cord-048466-fj9l8che	109	24	.	.	.
cord-048466-fj9l8che	110	1	In	in	IN
cord-048466-fj9l8che	110	2	our	-PRON-	PRP$
cord-048466-fj9l8che	110	3	dataset	dataset	NN
cord-048466-fj9l8che	110	4	we	-PRON-	PRP
cord-048466-fj9l8che	110	5	found	find	VBD
cord-048466-fj9l8che	110	6	several	several	JJ
cord-048466-fj9l8che	110	7	substitutions	substitution	NNS
cord-048466-fj9l8che	110	8	in	in	IN
cord-048466-fj9l8che	110	9	regions	region	NNS
cord-048466-fj9l8che	110	10	involved	involve	VBN
cord-048466-fj9l8che	110	11	in	in	IN
cord-048466-fj9l8che	110	12	protective	protective	JJ
cord-048466-fj9l8che	110	13	T	t	NN
cord-048466-fj9l8che	110	14	-	-	HYPH
cord-048466-fj9l8che	110	15	cell	cell	NN
cord-048466-fj9l8che	110	16	response	response	NN
cord-048466-fj9l8che	110	17	[	[	-LRB-
cord-048466-fj9l8che	110	18	48	48	CD
cord-048466-fj9l8che	110	19	]	]	-RRB-
cord-048466-fj9l8che	110	20	in	in	IN
cord-048466-fj9l8che	110	21	NA	NA	NNP
cord-048466-fj9l8che	110	22	,	,	,
cord-048466-fj9l8che	110	23	PA	PA	NNP
cord-048466-fj9l8che	110	24	,	,	,
cord-048466-fj9l8che	110	25	M1	M1	NNP
cord-048466-fj9l8che	110	26	,	,	,
cord-048466-fj9l8che	110	27	NS1	NS1	NNS
cord-048466-fj9l8che	110	28	and	and	CC
cord-048466-fj9l8che	110	29	most	most	JJS
cord-048466-fj9l8che	110	30	in	in	IN
cord-048466-fj9l8che	110	31	the	the	DT
cord-048466-fj9l8che	110	32	NP	NP	NNP
cord-048466-fj9l8che	110	33	protein	protein	NN
cord-048466-fj9l8che	110	34	.	.	.
cord-048466-fj9l8che	111	1	This	this	DT
cord-048466-fj9l8che	111	2	is	be	VBZ
cord-048466-fj9l8che	111	3	not	not	RB
cord-048466-fj9l8che	111	4	unexpected	unexpected	JJ
cord-048466-fj9l8che	111	5	because	because	IN
cord-048466-fj9l8che	111	6	most	most	JJS
cord-048466-fj9l8che	111	7	T	t	NN
cord-048466-fj9l8che	111	8	-	-	HYPH
cord-048466-fj9l8che	111	9	cell	cell	NN
cord-048466-fj9l8che	111	10	epitopes	epitope	NNS
cord-048466-fj9l8che	111	11	are	be	VBP
cord-048466-fj9l8che	111	12	defined	define	VBN
cord-048466-fj9l8che	111	13	for	for	IN
cord-048466-fj9l8che	111	14	the	the	DT
cord-048466-fj9l8che	111	15	NP	NP	NNP
cord-048466-fj9l8che	111	16	protein	protein	NN
cord-048466-fj9l8che	111	17	and	and	CC
cord-048466-fj9l8che	111	18	this	this	DT
cord-048466-fj9l8che	111	19	protein	protein	NN
cord-048466-fj9l8che	111	20	is	be	VBZ
cord-048466-fj9l8che	111	21	the	the	DT
cord-048466-fj9l8che	111	22	main	main	JJ
cord-048466-fj9l8che	111	23	target	target	NN
cord-048466-fj9l8che	111	24	for	for	IN
cord-048466-fj9l8che	111	25	the	the	DT
cord-048466-fj9l8che	111	26	cytotoxic	cytotoxic	JJ
cord-048466-fj9l8che	111	27	host	host	NN
cord-048466-fj9l8che	111	28	immune	immune	JJ
cord-048466-fj9l8che	111	29	response	response	NN
cord-048466-fj9l8che	111	30	[	[	-LRB-
cord-048466-fj9l8che	111	31	49	49	CD
cord-048466-fj9l8che	111	32	,	,	,
cord-048466-fj9l8che	111	33	50	50	CD
cord-048466-fj9l8che	111	34	]	]	-RRB-
cord-048466-fj9l8che	111	35	.	.	.
cord-048466-fj9l8che	112	1	The	the	DT
cord-048466-fj9l8che	112	2	extensive	extensive	JJ
cord-048466-fj9l8che	112	3	variations	variation	NNS
cord-048466-fj9l8che	112	4	in	in	IN
cord-048466-fj9l8che	112	5	the	the	DT
cord-048466-fj9l8che	112	6	T	t	NN
cord-048466-fj9l8che	112	7	-	-	HYPH
cord-048466-fj9l8che	112	8	cell	cell	NN
cord-048466-fj9l8che	112	9	epitopes	epitope	NNS
cord-048466-fj9l8che	112	10	during	during	IN
cord-048466-fj9l8che	112	11	1999	1999	CD
cord-048466-fj9l8che	112	12	to	to	IN
cord-048466-fj9l8che	112	13	2006	2006	CD
cord-048466-fj9l8che	112	14	suggest	suggest	VBP
cord-048466-fj9l8che	112	15	that	that	IN
cord-048466-fj9l8che	112	16	these	these	DT
cord-048466-fj9l8che	112	17	regions	region	NNS
cord-048466-fj9l8che	112	18	and	and	CC
cord-048466-fj9l8che	112	19	the	the	DT
cord-048466-fj9l8che	112	20	antibody	antibody	NN
cord-048466-fj9l8che	112	21	epitopes	epitope	NNS
cord-048466-fj9l8che	112	22	are	be	VBP
cord-048466-fj9l8che	112	23	working	work	VBG
cord-048466-fj9l8che	112	24	together	together	RB
cord-048466-fj9l8che	112	25	for	for	IN
cord-048466-fj9l8che	112	26	efficient	efficient	JJ
cord-048466-fj9l8che	112	27	escape	escape	NN
cord-048466-fj9l8che	112	28	from	from	IN
cord-048466-fj9l8che	112	29	the	the	DT
cord-048466-fj9l8che	112	30	host	host	NN
cord-048466-fj9l8che	112	31	defence	defence	NN
cord-048466-fj9l8che	112	32	responses	response	NNS
cord-048466-fj9l8che	112	33	.	.	.
cord-048466-fj9l8che	113	1	The	the	DT
cord-048466-fj9l8che	113	2	M2	M2	NNP
cord-048466-fj9l8che	113	3	proteins	protein	NNS
cord-048466-fj9l8che	113	4	from	from	IN
cord-048466-fj9l8che	113	5	the	the	DT
cord-048466-fj9l8che	113	6	Danish	danish	JJ
cord-048466-fj9l8che	113	7	Wisconsin	Wisconsin	NNP
cord-048466-fj9l8che	113	8	-	-	HYPH
cord-048466-fj9l8che	113	9	like	like	JJ
cord-048466-fj9l8che	113	10	viruses	virus	NNS
cord-048466-fj9l8che	113	11	in	in	IN
cord-048466-fj9l8che	113	12	2005	2005	CD
cord-048466-fj9l8che	113	13	-	-	SYM
cord-048466-fj9l8che	113	14	2006	2006	CD
cord-048466-fj9l8che	113	15	possessed	possess	VBD
cord-048466-fj9l8che	113	16	the	the	DT
cord-048466-fj9l8che	113	17	substitution	substitution	NN
cord-048466-fj9l8che	113	18	S31N	s31n	NN
cord-048466-fj9l8che	113	19	,	,	,
cord-048466-fj9l8che	113	20	associated	associate	VBN
cord-048466-fj9l8che	113	21	with	with	IN
cord-048466-fj9l8che	113	22	resistance	resistance	NN
cord-048466-fj9l8che	113	23	to	to	TO
cord-048466-fj9l8che	113	24	matrix	matrix	VB
cord-048466-fj9l8che	113	25	inhibitory	inhibitory	JJ
cord-048466-fj9l8che	113	26	drugs	drug	NNS
cord-048466-fj9l8che	113	27	,	,	,
cord-048466-fj9l8che	113	28	like	like	IN
cord-048466-fj9l8che	113	29	amantadine	amantadine	NNP
cord-048466-fj9l8che	113	30	[	[	-LRB-
cord-048466-fj9l8che	113	31	22	22	CD
cord-048466-fj9l8che	113	32	,	,	,
cord-048466-fj9l8che	113	33	44	44	CD
cord-048466-fj9l8che	113	34	,	,	,
cord-048466-fj9l8che	113	35	45	45	CD
cord-048466-fj9l8che	113	36	,	,	,
cord-048466-fj9l8che	113	37	51	51	CD
cord-048466-fj9l8che	113	38	]	]	-RRB-
cord-048466-fj9l8che	113	39	.	.	.
cord-048466-fj9l8che	114	1	These	these	DT
cord-048466-fj9l8che	114	2	types	type	NNS
cord-048466-fj9l8che	114	3	of	of	IN
cord-048466-fj9l8che	114	4	drugs	drug	NNS
cord-048466-fj9l8che	114	5	are	be	VBP
cord-048466-fj9l8che	114	6	not	not	RB
cord-048466-fj9l8che	114	7	used	use	VBN
cord-048466-fj9l8che	114	8	for	for	IN
cord-048466-fj9l8che	114	9	prophylaxis	prophylaxis	NN
cord-048466-fj9l8che	114	10	or	or	CC
cord-048466-fj9l8che	114	11	treatment	treatment	NN
cord-048466-fj9l8che	114	12	in	in	IN
cord-048466-fj9l8che	114	13	Denmark	Denmark	NNP
cord-048466-fj9l8che	114	14	.	.	.
cord-048466-fj9l8che	115	1	The	the	DT
cord-048466-fj9l8che	115	2	S31N	S31N	NNP
cord-048466-fj9l8che	115	3	substitution	substitution	NN
cord-048466-fj9l8che	115	4	is	be	VBZ
cord-048466-fj9l8che	115	5	therefore	therefore	RB
cord-048466-fj9l8che	115	6	not	not	RB
cord-048466-fj9l8che	115	7	a	a	DT
cord-048466-fj9l8che	115	8	local	local	JJ
cord-048466-fj9l8che	115	9	introduced	introduce	VBN
cord-048466-fj9l8che	115	10	resistance	resistance	NN
cord-048466-fj9l8che	115	11	mutation	mutation	NN
cord-048466-fj9l8che	115	12	.	.	.
cord-048466-fj9l8che	116	1	We	-PRON-	PRP
cord-048466-fj9l8che	116	2	can	can	MD
cord-048466-fj9l8che	116	3	not	not	RB
cord-048466-fj9l8che	116	4	exclude	exclude	VB
cord-048466-fj9l8che	116	5	that	that	IN
cord-048466-fj9l8che	116	6	this	this	DT
cord-048466-fj9l8che	116	7	substitution	substitution	NN
cord-048466-fj9l8che	116	8	has	have	VBZ
cord-048466-fj9l8che	116	9	arisen	arise	VBN
cord-048466-fj9l8che	116	10	by	by	IN
cord-048466-fj9l8che	116	11	chance	chance	NN
cord-048466-fj9l8che	116	12	,	,	,
cord-048466-fj9l8che	116	13	but	but	CC
cord-048466-fj9l8che	116	14	it	-PRON-	PRP
cord-048466-fj9l8che	116	15	is	be	VBZ
cord-048466-fj9l8che	116	16	more	more	RBR
cord-048466-fj9l8che	116	17	likely	likely	JJ
cord-048466-fj9l8che	116	18	that	that	IN
cord-048466-fj9l8che	116	19	the	the	DT
cord-048466-fj9l8che	116	20	mutation	mutation	NN
cord-048466-fj9l8che	116	21	has	have	VBZ
cord-048466-fj9l8che	116	22	emerged	emerge	VBN
cord-048466-fj9l8che	116	23	as	as	IN
cord-048466-fj9l8che	116	24	a	a	DT
cord-048466-fj9l8che	116	25	resistance	resistance	NN
cord-048466-fj9l8che	116	26	mutation	mutation	NN
cord-048466-fj9l8che	116	27	in	in	IN
cord-048466-fj9l8che	116	28	other	other	JJ
cord-048466-fj9l8che	116	29	countries	country	NNS
cord-048466-fj9l8che	116	30	like	like	IN
cord-048466-fj9l8che	116	31	the	the	DT
cord-048466-fj9l8che	116	32	USA	USA	NNP
cord-048466-fj9l8che	116	33	[	[	-LRB-
cord-048466-fj9l8che	116	34	52	52	CD
cord-048466-fj9l8che	116	35	]	]	-RRB-
cord-048466-fj9l8che	116	36	and	and	CC
cord-048466-fj9l8che	116	37	Australia	Australia	NNP
cord-048466-fj9l8che	116	38	[	[	-LRB-
cord-048466-fj9l8che	116	39	53	53	CD
cord-048466-fj9l8che	116	40	]	]	-RRB-
cord-048466-fj9l8che	116	41	where	where	WRB
cord-048466-fj9l8che	116	42	the	the	DT
cord-048466-fj9l8che	116	43	prevalence	prevalence	NN
cord-048466-fj9l8che	116	44	of	of	IN
cord-048466-fj9l8che	116	45	amantadine	amantadine	NNP
cord-048466-fj9l8che	116	46	resistance	resistance	NN
cord-048466-fj9l8che	116	47	is	be	VBZ
cord-048466-fj9l8che	116	48	high	high	JJ
cord-048466-fj9l8che	116	49	.	.	.
cord-048466-fj9l8che	117	1	The	the	DT
cord-048466-fj9l8che	117	2	resistance	resistance	NN
cord-048466-fj9l8che	117	3	may	may	MD
cord-048466-fj9l8che	117	4	also	also	RB
cord-048466-fj9l8che	117	5	be	be	VB
cord-048466-fj9l8che	117	6	related	relate	VBN
cord-048466-fj9l8che	117	7	to	to	IN
cord-048466-fj9l8che	117	8	the	the	DT
cord-048466-fj9l8che	117	9	increased	increase	VBN
cord-048466-fj9l8che	117	10	use	use	NN
cord-048466-fj9l8che	117	11	of	of	IN
cord-048466-fj9l8che	117	12	this	this	DT
cord-048466-fj9l8che	117	13	drug	drug	NN
cord-048466-fj9l8che	117	14	in	in	IN
cord-048466-fj9l8che	117	15	Asia	Asia	NNP
cord-048466-fj9l8che	117	16	during	during	IN
cord-048466-fj9l8che	117	17	the	the	DT
cord-048466-fj9l8che	117	18	SARS	SARS	NNP
cord-048466-fj9l8che	117	19	epidemic	epidemic	NN
cord-048466-fj9l8che	117	20	[	[	-LRB-
cord-048466-fj9l8che	117	21	21	21	CD
cord-048466-fj9l8che	117	22	]	]	-RRB-
cord-048466-fj9l8che	117	23	.	.	.
cord-048466-fj9l8che	118	1	The	the	DT
cord-048466-fj9l8che	118	2	A	A	NNP
cord-048466-fj9l8che	118	3	/	/	SYM
cord-048466-fj9l8che	118	4	Fujian/411/02(H3N2)-like	Fujian/411/02(H3N2)-like	NNP
cord-048466-fj9l8che	118	5	clinical	clinical	JJ
cord-048466-fj9l8che	118	6	Danish	danish	JJ
cord-048466-fj9l8che	118	7	viruses	virus	NNS
cord-048466-fj9l8che	118	8	had	have	VBD
cord-048466-fj9l8che	118	9	several	several	JJ
cord-048466-fj9l8che	118	10	substitutions	substitution	NNS
cord-048466-fj9l8che	118	11	in	in	IN
cord-048466-fj9l8che	118	12	HA	HA	NNP
cord-048466-fj9l8che	118	13	at	at	IN
cord-048466-fj9l8che	118	14	sites	site	NNS
cord-048466-fj9l8che	118	15	that	that	WDT
cord-048466-fj9l8che	118	16	might	may	MD
cord-048466-fj9l8che	118	17	influence	influence	VB
cord-048466-fj9l8che	118	18	the	the	DT
cord-048466-fj9l8che	118	19	virus	virus	NN
cord-048466-fj9l8che	118	20	'	'	''
cord-048466-fj9l8che	118	21	capability	capability	NN
cord-048466-fj9l8che	118	22	for	for	IN
cord-048466-fj9l8che	118	23	egg	egg	NN
cord-048466-fj9l8che	118	24	growth	growth	NN
cord-048466-fj9l8che	118	25	[	[	-LRB-
cord-048466-fj9l8che	118	26	10	10	CD
cord-048466-fj9l8che	118	27	,	,	,
cord-048466-fj9l8che	118	28	37	37	CD
cord-048466-fj9l8che	118	29	]	]	-RRB-
cord-048466-fj9l8che	118	30	.	.	.
cord-048466-fj9l8che	119	1	These	these	DT
cord-048466-fj9l8che	119	2	include	include	VBP
cord-048466-fj9l8che	119	3	;	;	:
cord-048466-fj9l8che	119	4	A131	A131	``
cord-048466-fj9l8che	119	5	T	t	NN
cord-048466-fj9l8che	119	6	,	,	,
cord-048466-fj9l8che	119	7	I144N	I144N	NNP
cord-048466-fj9l8che	119	8	,	,	,
cord-048466-fj9l8che	119	9	H155	H155	NNP
cord-048466-fj9l8che	119	10	T	T	NNP
cord-048466-fj9l8che	119	11	,	,	,
cord-048466-fj9l8che	119	12	Q156H	Q156H	NNP
cord-048466-fj9l8che	119	13	,	,	,
cord-048466-fj9l8che	119	14	W222R	w222r	NN
cord-048466-fj9l8che	119	15	and	and	CC
cord-048466-fj9l8che	119	16	G225D.	g225d.	NN
cord-048466-fj9l8che	120	1	The	the	DT
cord-048466-fj9l8che	120	2	A	A	NNP
cord-048466-fj9l8che	120	3	/	/	SYM
cord-048466-fj9l8che	120	4	California/20/99(H3N2)-like	california/20/99(h3n2)-like	JJ
cord-048466-fj9l8che	120	5	viruses	virus	NNS
cord-048466-fj9l8che	120	6	had	have	VBD
cord-048466-fj9l8che	120	7	further	further	JJ
cord-048466-fj9l8che	120	8	changes	change	NNS
cord-048466-fj9l8che	120	9	at	at	IN
cord-048466-fj9l8che	120	10	positions	position	NNS
cord-048466-fj9l8che	120	11	K145S	K145S	NNP
cord-048466-fj9l8che	120	12	/	/	SYM
cord-048466-fj9l8che	120	13	N	n	CD
cord-048466-fj9l8che	120	14	,	,	,
cord-048466-fj9l8che	120	15	Y159F	y159f	UH
cord-048466-fj9l8che	120	16	,	,	,
cord-048466-fj9l8che	120	17	S193F	S193F	NNP
cord-048466-fj9l8che	120	18	and	and	CC
cord-048466-fj9l8che	120	19	V226I	v226i	NN
cord-048466-fj9l8che	120	20	and	and	CC
cord-048466-fj9l8che	120	21	A	A	NNP
cord-048466-fj9l8che	120	22	/	/	SYM
cord-048466-fj9l8che	120	23	Wisconsin/67/05(H3N2	wisconsin/67/05(h3n2	NN
cord-048466-fj9l8che	120	24	)	)	-RRB-
cord-048466-fj9l8che	120	25	possessed	possess	VBD
cord-048466-fj9l8che	120	26	in	in	IN
cord-048466-fj9l8che	120	27	addition	addition	NN
cord-048466-fj9l8che	120	28	S193F	S193F	NNS
cord-048466-fj9l8che	120	29	and	and	CC
cord-048466-fj9l8che	120	30	D225N.	D225N.	NNP
cord-048466-fj9l8che	121	1	All	all	DT
cord-048466-fj9l8che	121	2	isolates	isolate	NNS
cord-048466-fj9l8che	121	3	after	after	IN
cord-048466-fj9l8che	121	4	the	the	DT
cord-048466-fj9l8che	121	5	1999	1999	CD
cord-048466-fj9l8che	121	6	-	-	SYM
cord-048466-fj9l8che	121	7	2000	2000	CD
cord-048466-fj9l8che	122	1	A	a	LS
cord-048466-fj9l8che	122	2	/	/	SYM
cord-048466-fj9l8che	122	3	Moscow/10/99(H3N2)-like	moscow/10/99(h3n2)-like	NN
cord-048466-fj9l8che	122	4	viruses	virus	NNS
cord-048466-fj9l8che	122	5	possess	possess	VBP
cord-048466-fj9l8che	122	6	S186G.	S186G.	.
cord-048466-fj9l8che	123	1	In	in	IN
cord-048466-fj9l8che	123	2	recent	recent	JJ
cord-048466-fj9l8che	123	3	years	year	NNS
cord-048466-fj9l8che	123	4	H3N2	H3N2	NNP
cord-048466-fj9l8che	123	5	viruses	virus	NNS
cord-048466-fj9l8che	123	6	have	have	VBP
cord-048466-fj9l8che	123	7	had	have	VBN
cord-048466-fj9l8che	123	8	poor	poor	JJ
cord-048466-fj9l8che	123	9	replication	replication	NN
cord-048466-fj9l8che	123	10	efficiency	efficiency	NN
cord-048466-fj9l8che	123	11	in	in	IN
cord-048466-fj9l8che	123	12	eggs	egg	NNS
cord-048466-fj9l8che	123	13	[	[	-LRB-
cord-048466-fj9l8che	123	14	54	54	CD
cord-048466-fj9l8che	123	15	,	,	,
cord-048466-fj9l8che	123	16	55	55	CD
cord-048466-fj9l8che	123	17	]	]	-RRB-
cord-048466-fj9l8che	123	18	.	.	.
cord-048466-fj9l8che	124	1	It	-PRON-	PRP
cord-048466-fj9l8che	124	2	has	have	VBZ
cord-048466-fj9l8che	124	3	been	be	VBN
cord-048466-fj9l8che	124	4	shown	show	VBN
cord-048466-fj9l8che	124	5	that	that	IN
cord-048466-fj9l8che	124	6	positions	position	NNS
cord-048466-fj9l8che	124	7	186	186	CD
cord-048466-fj9l8che	124	8	,	,	,
cord-048466-fj9l8che	124	9	226	226	CD
cord-048466-fj9l8che	124	10	and	and	CC
cord-048466-fj9l8che	124	11	196	196	CD
cord-048466-fj9l8che	124	12	are	be	VBP
cord-048466-fj9l8che	124	13	critical	critical	JJ
cord-048466-fj9l8che	124	14	determinants	determinant	NNS
cord-048466-fj9l8che	124	15	for	for	IN
cord-048466-fj9l8che	124	16	egg	egg	NN
cord-048466-fj9l8che	124	17	growth	growth	NN
cord-048466-fj9l8che	124	18	.	.	.
cord-048466-fj9l8che	125	1	The	the	DT
cord-048466-fj9l8che	125	2	changes	change	NNS
cord-048466-fj9l8che	125	3	G186V	G186V	VBZ
cord-048466-fj9l8che	125	4	and	and	CC
cord-048466-fj9l8che	125	5	V226I	v226i	NN
cord-048466-fj9l8che	125	6	increased	increase	VBD
cord-048466-fj9l8che	125	7	egg	egg	NN
cord-048466-fj9l8che	125	8	viral	viral	JJ
cord-048466-fj9l8che	125	9	replica	replica	NN
cord-048466-fj9l8che	125	10	-	-	HYPH
cord-048466-fj9l8che	125	11	tion	tion	NN
cord-048466-fj9l8che	125	12	of	of	IN
cord-048466-fj9l8che	125	13	A	a	NN
cord-048466-fj9l8che	125	14	/	/	SYM
cord-048466-fj9l8che	125	15	Fujian/411/02(H3N2	fujian/411/02(h3n2	JJ
cord-048466-fj9l8che	125	16	)	)	-RRB-
cord-048466-fj9l8che	125	17	viruses	virus	NNS
cord-048466-fj9l8che	126	1	so	so	RB
cord-048466-fj9l8che	126	2	did	do	VBD
cord-048466-fj9l8che	126	3	the	the	DT
cord-048466-fj9l8che	126	4	changes	change	NNS
cord-048466-fj9l8che	126	5	G186V	G186V	NNS
cord-048466-fj9l8che	126	6	and	and	CC
cord-048466-fj9l8che	126	7	A196	A196	NNP
cord-048466-fj9l8che	126	8	T	T	NNP
cord-048466-fj9l8che	126	9	for	for	IN
cord-048466-fj9l8che	126	10	A	a	NN
cord-048466-fj9l8che	126	11	/	/	SYM
cord-048466-fj9l8che	126	12	California/20/	california/20/	NN
cord-048466-fj9l8che	126	13	99(H3N2	99(h3n2	LS
cord-048466-fj9l8che	126	14	)	)	-RRB-
cord-048466-fj9l8che	126	15	viruses	virus	NNS
cord-048466-fj9l8che	126	16	[	[	-LRB-
cord-048466-fj9l8che	126	17	56	56	CD
cord-048466-fj9l8che	126	18	,	,	,
cord-048466-fj9l8che	126	19	57	57	CD
cord-048466-fj9l8che	126	20	]	]	-RRB-
cord-048466-fj9l8che	126	21	.	.	.
cord-048466-fj9l8che	127	1	On	on	IN
cord-048466-fj9l8che	127	2	the	the	DT
cord-048466-fj9l8che	127	3	contrary	contrary	NN
cord-048466-fj9l8che	127	4	,	,	,
cord-048466-fj9l8che	127	5	others	other	NNS
cord-048466-fj9l8che	127	6	have	have	VBP
cord-048466-fj9l8che	127	7	stated	state	VBN
cord-048466-fj9l8che	127	8	that	that	IN
cord-048466-fj9l8che	127	9	the	the	DT
cord-048466-fj9l8che	127	10	V226I	v226i	NN
cord-048466-fj9l8che	127	11	change	change	NN
cord-048466-fj9l8che	127	12	in	in	IN
cord-048466-fj9l8che	127	13	combination	combination	NN
cord-048466-fj9l8che	127	14	with	with	IN
cord-048466-fj9l8che	127	15	T155	T155	NNP
cord-048466-fj9l8che	127	16	and	and	CC
cord-048466-fj9l8che	127	17	H156	H156	NNPS
cord-048466-fj9l8che	127	18	do	do	VBP
cord-048466-fj9l8che	127	19	not	not	RB
cord-048466-fj9l8che	127	20	result	result	VB
cord-048466-fj9l8che	127	21	in	in	IN
cord-048466-fj9l8che	127	22	viral	viral	JJ
cord-048466-fj9l8che	127	23	recovery	recovery	NN
cord-048466-fj9l8che	127	24	in	in	IN
cord-048466-fj9l8che	127	25	eggs	egg	NNS
cord-048466-fj9l8che	127	26	[	[	-LRB-
cord-048466-fj9l8che	127	27	37	37	CD
cord-048466-fj9l8che	127	28	,	,	,
cord-048466-fj9l8che	127	29	54	54	CD
cord-048466-fj9l8che	127	30	]	]	-RRB-
cord-048466-fj9l8che	127	31	.	.	.
cord-048466-fj9l8che	128	1	This	this	DT
cord-048466-fj9l8che	128	2	might	may	MD
cord-048466-fj9l8che	128	3	explain	explain	VB
cord-048466-fj9l8che	128	4	the	the	DT
cord-048466-fj9l8che	128	5	delay	delay	NN
cord-048466-fj9l8che	128	6	in	in	IN
cord-048466-fj9l8che	128	7	the	the	DT
cord-048466-fj9l8che	128	8	2006	2006	CD
cord-048466-fj9l8che	128	9	-	-	SYM
cord-048466-fj9l8che	128	10	2007	2007	CD
cord-048466-fj9l8che	128	11	vaccine	vaccine	NN
cord-048466-fj9l8che	128	12	production	production	NN
cord-048466-fj9l8che	128	13	for	for	IN
cord-048466-fj9l8che	128	14	the	the	DT
cord-048466-fj9l8che	128	15	northern	northern	JJ
cord-048466-fj9l8che	128	16	hemisphere	hemisphere	NN
cord-048466-fj9l8che	128	17	due	due	IN
cord-048466-fj9l8che	128	18	to	to	IN
cord-048466-fj9l8che	128	19	egg	egg	NN
cord-048466-fj9l8che	128	20	propagation	propagation	NN
cord-048466-fj9l8che	128	21	difficulties	difficulty	NNS
cord-048466-fj9l8che	128	22	with	with	IN
cord-048466-fj9l8che	128	23	the	the	DT
cord-048466-fj9l8che	128	24	A	A	NNP
cord-048466-fj9l8che	128	25	/	/	SYM
cord-048466-fj9l8che	128	26	Wisconsin/67/05(H3N2	wisconsin/67/05(h3n2	NN
cord-048466-fj9l8che	128	27	)	)	-RRB-
cord-048466-fj9l8che	128	28	strain	strain	NN
cord-048466-fj9l8che	128	29	.	.	.
cord-048466-fj9l8che	129	1	The	the	DT
cord-048466-fj9l8che	129	2	influence	influence	NN
cord-048466-fj9l8che	129	3	on	on	IN
cord-048466-fj9l8che	129	4	replication	replication	NN
cord-048466-fj9l8che	129	5	efficiency	efficiency	NN
cord-048466-fj9l8che	129	6	by	by	IN
cord-048466-fj9l8che	129	7	the	the	DT
cord-048466-fj9l8che	129	8	other	other	JJ
cord-048466-fj9l8che	129	9	substitutions	substitution	NNS
cord-048466-fj9l8che	129	10	observed	observe	VBN
cord-048466-fj9l8che	129	11	at	at	IN
cord-048466-fj9l8che	129	12	receptor	receptor	NN
cord-048466-fj9l8che	129	13	binding	bind	VBG
cord-048466-fj9l8che	129	14	sites	site	NNS
cord-048466-fj9l8che	129	15	should	should	MD
cord-048466-fj9l8che	129	16	be	be	VB
cord-048466-fj9l8che	129	17	investigated	investigate	VBN
cord-048466-fj9l8che	129	18	further	further	RB
cord-048466-fj9l8che	129	19	.	.	.
cord-048466-fj9l8che	130	1	We	-PRON-	PRP
cord-048466-fj9l8che	130	2	did	do	VBD
cord-048466-fj9l8che	130	3	not	not	RB
cord-048466-fj9l8che	130	4	observe	observe	VB
cord-048466-fj9l8che	130	5	amino	amino	JJ
cord-048466-fj9l8che	130	6	acids	acid	NNS
cord-048466-fj9l8che	130	7	in	in	IN
cord-048466-fj9l8che	130	8	the	the	DT
cord-048466-fj9l8che	130	9	N2	N2	NNP
cord-048466-fj9l8che	130	10	NA	NA	NNP
cord-048466-fj9l8che	130	11	protein	protein	NN
cord-048466-fj9l8che	130	12	that	that	WDT
cord-048466-fj9l8che	130	13	would	would	MD
cord-048466-fj9l8che	130	14	decrease	decrease	VB
cord-048466-fj9l8che	130	15	virus	virus	NN
cord-048466-fj9l8che	130	16	replication	replication	NN
cord-048466-fj9l8che	130	17	in	in	IN
cord-048466-fj9l8che	130	18	eggs	egg	NNS
cord-048466-fj9l8che	130	19	.	.	.
cord-048466-fj9l8che	131	1	The	the	DT
cord-048466-fj9l8che	131	2	amino	amino	NN
cord-048466-fj9l8che	131	3	acids	acid	NNS
cord-048466-fj9l8che	131	4	known	know	VBN
cord-048466-fj9l8che	131	5	to	to	TO
cord-048466-fj9l8che	131	6	give	give	VB
cord-048466-fj9l8che	131	7	good	good	JJ
cord-048466-fj9l8che	131	8	replication	replication	NN
cord-048466-fj9l8che	131	9	in	in	IN
cord-048466-fj9l8che	131	10	eggs	egg	NNS
cord-048466-fj9l8che	131	11	(	(	-LRB-
cord-048466-fj9l8che	131	12	Q119	Q119	NNP
cord-048466-fj9l8che	131	13	,	,	,
cord-048466-fj9l8che	131	14	K136	k136	CD
cord-048466-fj9l8che	131	15	and	and	CC
cord-048466-fj9l8che	131	16	Y347	y347	CD
cord-048466-fj9l8che	131	17	)	)	-RRB-
cord-048466-fj9l8che	132	1	[	[	-LRB-
cord-048466-fj9l8che	132	2	56	56	CD
cord-048466-fj9l8che	132	3	]	]	-RRB-
cord-048466-fj9l8che	132	4	were	be	VBD
cord-048466-fj9l8che	132	5	all	all	DT
cord-048466-fj9l8che	132	6	present	present	JJ
cord-048466-fj9l8che	132	7	in	in	IN
cord-048466-fj9l8che	132	8	this	this	DT
cord-048466-fj9l8che	132	9	dataset	dataset	NN
cord-048466-fj9l8che	132	10	.	.	.
cord-048466-fj9l8che	133	1	Oligosaccharides	oligosaccharide	NNS
cord-048466-fj9l8che	133	2	at	at	IN
cord-048466-fj9l8che	133	3	the	the	DT
cord-048466-fj9l8che	133	4	surface	surface	NN
cord-048466-fj9l8che	133	5	proteins	protein	NNS
cord-048466-fj9l8che	133	6	HA	HA	NNP
cord-048466-fj9l8che	133	7	and	and	CC
cord-048466-fj9l8che	133	8	NA	NA	NNP
cord-048466-fj9l8che	133	9	might	may	MD
cord-048466-fj9l8che	133	10	have	have	VB
cord-048466-fj9l8che	133	11	greater	great	JJR
cord-048466-fj9l8che	133	12	impact	impact	NN
cord-048466-fj9l8che	133	13	on	on	IN
cord-048466-fj9l8che	133	14	viral	viral	JJ
cord-048466-fj9l8che	133	15	escape	escape	NN
cord-048466-fj9l8che	133	16	from	from	IN
cord-048466-fj9l8che	133	17	the	the	DT
cord-048466-fj9l8che	133	18	immune	immune	JJ
cord-048466-fj9l8che	133	19	system	system	NN
cord-048466-fj9l8che	133	20	than	than	IN
cord-048466-fj9l8che	133	21	single	single	JJ
cord-048466-fj9l8che	133	22	amino	amino	NN
cord-048466-fj9l8che	133	23	acid	acid	NN
cord-048466-fj9l8che	133	24	changes	change	NNS
cord-048466-fj9l8che	133	25	in	in	IN
cord-048466-fj9l8che	133	26	the	the	DT
cord-048466-fj9l8che	133	27	antigenic	antigenic	JJ
cord-048466-fj9l8che	133	28	sites	site	NNS
cord-048466-fj9l8che	133	29	.	.	.
cord-048466-fj9l8che	134	1	Oligosaccharides	oligosaccharide	NNS
cord-048466-fj9l8che	134	2	which	which	WDT
cord-048466-fj9l8che	134	3	are	be	VBP
cord-048466-fj9l8che	134	4	recognised	recognise	VBN
cord-048466-fj9l8che	134	5	as	as	IN
cord-048466-fj9l8che	134	6	"	"	``
cord-048466-fj9l8che	134	7	self	self	NN
cord-048466-fj9l8che	134	8	"	"	''
cord-048466-fj9l8che	134	9	by	by	IN
cord-048466-fj9l8che	134	10	the	the	DT
cord-048466-fj9l8che	134	11	host	host	NN
cord-048466-fj9l8che	134	12	immune	immune	JJ
cord-048466-fj9l8che	134	13	system	system	NN
cord-048466-fj9l8che	134	14	may	may	MD
cord-048466-fj9l8che	134	15	pose	pose	VB
cord-048466-fj9l8che	134	16	conformational	conformational	JJ
cord-048466-fj9l8che	134	17	changes	change	NNS
cord-048466-fj9l8che	134	18	in	in	IN
cord-048466-fj9l8che	134	19	the	the	DT
cord-048466-fj9l8che	134	20	molecule	molecule	NN
cord-048466-fj9l8che	134	21	and	and	CC
cord-048466-fj9l8che	134	22	mask	mask	NN
cord-048466-fj9l8che	134	23	antigenic	antigenic	JJ
cord-048466-fj9l8che	134	24	sites	site	NNS
cord-048466-fj9l8che	134	25	,	,	,
cord-048466-fj9l8che	134	26	thereby	thereby	RB
cord-048466-fj9l8che	134	27	prevent	prevent	VB
cord-048466-fj9l8che	134	28	binding	binding	NN
cord-048466-fj9l8che	134	29	of	of	IN
cord-048466-fj9l8che	134	30	host	host	NN
cord-048466-fj9l8che	134	31	antibodies	antibody	NNS
cord-048466-fj9l8che	134	32	.	.	.
cord-048466-fj9l8che	135	1	The	the	DT
cord-048466-fj9l8che	135	2	number	number	NN
cord-048466-fj9l8che	135	3	of	of	IN
cord-048466-fj9l8che	135	4	N	n	CD
cord-048466-fj9l8che	135	5	-	-	HYPH
cord-048466-fj9l8che	135	6	linked	link	VBN
cord-048466-fj9l8che	135	7	glycosylation	glycosylation	NN
cord-048466-fj9l8che	135	8	sites	site	NNS
cord-048466-fj9l8che	135	9	in	in	IN
cord-048466-fj9l8che	135	10	the	the	DT
cord-048466-fj9l8che	135	11	H3	H3	NNP
cord-048466-fj9l8che	135	12	HA	HA	NNP
cord-048466-fj9l8che	135	13	protein	protein	NN
cord-048466-fj9l8che	135	14	has	have	VBZ
cord-048466-fj9l8che	135	15	increased	increase	VBN
cord-048466-fj9l8che	135	16	during	during	IN
cord-048466-fj9l8che	135	17	the	the	DT
cord-048466-fj9l8che	135	18	years	year	NNS
cord-048466-fj9l8che	135	19	from	from	IN
cord-048466-fj9l8che	135	20	only	only	RB
cord-048466-fj9l8che	135	21	three	three	CD
cord-048466-fj9l8che	135	22	attachment	attachment	NN
cord-048466-fj9l8che	135	23	sites	site	NNS
cord-048466-fj9l8che	135	24	in	in	IN
cord-048466-fj9l8che	135	25	1968	1968	CD
cord-048466-fj9l8che	135	26	[	[	-LRB-
cord-048466-fj9l8che	135	27	58	58	CD
cord-048466-fj9l8che	135	28	,	,	,
cord-048466-fj9l8che	135	29	59	59	CD
cord-048466-fj9l8che	135	30	]	]	-RRB-
cord-048466-fj9l8che	136	1	to	to	IN
cord-048466-fj9l8che	136	2	ten	ten	CD
cord-048466-fj9l8che	136	3	predicted	predict	VBN
cord-048466-fj9l8che	136	4	sites	site	NNS
cord-048466-fj9l8che	136	5	in	in	IN
cord-048466-fj9l8che	136	6	the	the	DT
cord-048466-fj9l8che	136	7	Danish	danish	JJ
cord-048466-fj9l8che	136	8	isolates	isolate	NNS
cord-048466-fj9l8che	136	9	after	after	IN
cord-048466-fj9l8che	136	10	2004	2004	CD
cord-048466-fj9l8che	136	11	.	.	.
cord-048466-fj9l8che	137	1	The	the	DT
cord-048466-fj9l8che	137	2	A	A	NNP
cord-048466-fj9l8che	137	3	/	/	SYM
cord-048466-fj9l8che	137	4	Fujian/411/02(H3N2)-like	Fujian/411/02(H3N2)-like	NNP
cord-048466-fj9l8che	137	5	stains	stain	NNS
cord-048466-fj9l8che	137	6	from	from	IN
cord-048466-fj9l8che	137	7	the	the	DT
cord-048466-fj9l8che	137	8	2002	2002	CD
cord-048466-fj9l8che	137	9	-	-	SYM
cord-048466-fj9l8che	137	10	2003	2003	CD
cord-048466-fj9l8che	137	11	season	season	NN
cord-048466-fj9l8che	137	12	gained	gain	VBD
cord-048466-fj9l8che	137	13	a	a	DT
cord-048466-fj9l8che	137	14	potential	potential	JJ
cord-048466-fj9l8che	137	15	glycosylation	glycosylation	NN
cord-048466-fj9l8che	137	16	site	site	NN
cord-048466-fj9l8che	137	17	at	at	IN
cord-048466-fj9l8che	137	18	position	position	NN
cord-048466-fj9l8che	137	19	144	144	CD
cord-048466-fj9l8che	137	20	,	,	,
cord-048466-fj9l8che	137	21	thereby	thereby	RB
cord-048466-fj9l8che	137	22	masking	mask	VBG
cord-048466-fj9l8che	137	23	the	the	DT
cord-048466-fj9l8che	137	24	supposed	supposed	JJ
cord-048466-fj9l8che	137	25	"	"	``
cord-048466-fj9l8che	137	26	key	key	JJ
cord-048466-fj9l8che	137	27	"	"	''
cord-048466-fj9l8che	137	28	site	site	NN
cord-048466-fj9l8che	137	29	for	for	IN
cord-048466-fj9l8che	137	30	antigenic	antigenic	JJ
cord-048466-fj9l8che	137	31	change	change	NN
cord-048466-fj9l8che	137	32	[	[	-LRB-
cord-048466-fj9l8che	137	33	33	33	CD
cord-048466-fj9l8che	137	34	]	]	-RRB-
cord-048466-fj9l8che	137	35	.	.	.
cord-048466-fj9l8che	138	1	Substitutions	substitution	NNS
cord-048466-fj9l8che	138	2	at	at	IN
cord-048466-fj9l8che	138	3	antigenic	antigenic	JJ
cord-048466-fj9l8che	138	4	site	site	NN
cord-048466-fj9l8che	138	5	B	b	NN
cord-048466-fj9l8che	138	6	and	and	CC
cord-048466-fj9l8che	138	7	the	the	DT
cord-048466-fj9l8che	138	8	predicted	predict	VBN
cord-048466-fj9l8che	138	9	N	n	NN
cord-048466-fj9l8che	138	10	-	-	HYPH
cord-048466-fj9l8che	138	11	glycosylation	glycosylation	NN
cord-048466-fj9l8che	138	12	at	at	IN
cord-048466-fj9l8che	138	13	position	position	NN
cord-048466-fj9l8che	138	14	144	144	CD
cord-048466-fj9l8che	138	15	in	in	IN
cord-048466-fj9l8che	138	16	HA	HA	NNP
cord-048466-fj9l8che	138	17	antigenic	antigenic	JJ
cord-048466-fj9l8che	138	18	site	site	NN
cord-048466-fj9l8che	138	19	A	a	NN
cord-048466-fj9l8che	138	20	together	together	RB
cord-048466-fj9l8che	138	21	with	with	IN
cord-048466-fj9l8che	138	22	a	a	DT
cord-048466-fj9l8che	138	23	stronger	strong	JJR
cord-048466-fj9l8che	138	24	NA	NA	NNP
cord-048466-fj9l8che	138	25	might	may	MD
cord-048466-fj9l8che	138	26	have	have	VB
cord-048466-fj9l8che	138	27	contributed	contribute	VBN
cord-048466-fj9l8che	138	28	to	to	IN
cord-048466-fj9l8che	138	29	the	the	DT
cord-048466-fj9l8che	138	30	increased	increase	VBN
cord-048466-fj9l8che	138	31	infectivity	infectivity	NN
cord-048466-fj9l8che	138	32	of	of	IN
cord-048466-fj9l8che	138	33	the	the	DT
cord-048466-fj9l8che	138	34	reassorted	reassorte	VBN
cord-048466-fj9l8che	138	35	Fujian	Fujian	NNP
cord-048466-fj9l8che	138	36	-	-	HYPH
cord-048466-fj9l8che	138	37	like	like	JJ
cord-048466-fj9l8che	138	38	viruses	virus	NNS
cord-048466-fj9l8che	138	39	of	of	IN
cord-048466-fj9l8che	138	40	the	the	DT
cord-048466-fj9l8che	138	41	2003	2003	CD
cord-048466-fj9l8che	138	42	-	-	SYM
cord-048466-fj9l8che	138	43	2004	2004	CD
cord-048466-fj9l8che	138	44	season	season	NN
cord-048466-fj9l8che	138	45	,	,	,
cord-048466-fj9l8che	138	46	causing	cause	VBG
cord-048466-fj9l8che	138	47	an	an	DT
cord-048466-fj9l8che	138	48	epidemic	epidemic	NN
cord-048466-fj9l8che	138	49	in	in	IN
cord-048466-fj9l8che	138	50	Denmark	Denmark	NNP
cord-048466-fj9l8che	138	51	.	.	.
cord-048466-fj9l8che	139	1	We	-PRON-	PRP
cord-048466-fj9l8che	139	2	have	have	VBP
cord-048466-fj9l8che	139	3	shown	show	VBN
cord-048466-fj9l8che	139	4	that	that	IN
cord-048466-fj9l8che	139	5	the	the	DT
cord-048466-fj9l8che	139	6	preferred	preferred	JJ
cord-048466-fj9l8che	139	7	antibody	antibody	NN
cord-048466-fj9l8che	139	8	epitope	epitope	NN
cord-048466-fj9l8che	139	9	for	for	IN
cord-048466-fj9l8che	139	10	genetic	genetic	JJ
cord-048466-fj9l8che	139	11	change	change	NN
cord-048466-fj9l8che	139	12	is	be	VBZ
cord-048466-fj9l8che	139	13	antigenic	antigenic	JJ
cord-048466-fj9l8che	139	14	site	site	NN
cord-048466-fj9l8che	139	15	B	b	NN
cord-048466-fj9l8che	139	16	for	for	IN
cord-048466-fj9l8che	139	17	the	the	DT
cord-048466-fj9l8che	139	18	Danish	danish	JJ
cord-048466-fj9l8che	139	19	dataset	dataset	NN
cord-048466-fj9l8che	139	20	also	also	RB
cord-048466-fj9l8che	139	21	reflecting	reflect	VBG
cord-048466-fj9l8che	139	22	that	that	DT
cord-048466-fj9l8che	139	23	site	site	NN
cord-048466-fj9l8che	140	1	A	a	DT
cord-048466-fj9l8che	140	2	is	be	VBZ
cord-048466-fj9l8che	140	3	camouflaged	camouflage	VBN
cord-048466-fj9l8che	140	4	by	by	IN
cord-048466-fj9l8che	140	5	glycosylation	glycosylation	NN
cord-048466-fj9l8che	140	6	.	.	.
cord-048466-fj9l8che	141	1	Thus	thus	RB
cord-048466-fj9l8che	141	2	the	the	DT
cord-048466-fj9l8che	141	3	antigenic	antigenic	JJ
cord-048466-fj9l8che	141	4	changes	change	NNS
cord-048466-fj9l8che	141	5	at	at	IN
cord-048466-fj9l8che	141	6	a	a	DT
cord-048466-fj9l8che	141	7	glycosylated	glycosylated	JJ
cord-048466-fj9l8che	141	8	site	site	NN
cord-048466-fj9l8che	141	9	A	a	NN
cord-048466-fj9l8che	141	10	may	may	MD
cord-048466-fj9l8che	141	11	not	not	RB
cord-048466-fj9l8che	141	12	play	play	VB
cord-048466-fj9l8che	141	13	a	a	DT
cord-048466-fj9l8che	141	14	major	major	JJ
cord-048466-fj9l8che	141	15	role	role	NN
cord-048466-fj9l8che	141	16	in	in	IN
cord-048466-fj9l8che	141	17	escape	escape	NN
cord-048466-fj9l8che	141	18	from	from	IN
cord-048466-fj9l8che	141	19	the	the	DT
cord-048466-fj9l8che	141	20	immune	immune	JJ
cord-048466-fj9l8che	141	21	system	system	NN
cord-048466-fj9l8che	141	22	as	as	RB
cord-048466-fj9l8che	141	23	long	long	RB
cord-048466-fj9l8che	141	24	as	as	IN
cord-048466-fj9l8che	141	25	the	the	DT
cord-048466-fj9l8che	141	26	glycosylation	glycosylation	NN
cord-048466-fj9l8che	141	27	is	be	VBZ
cord-048466-fj9l8che	141	28	present	present	JJ
cord-048466-fj9l8che	141	29	.	.	.
cord-048466-fj9l8che	142	1	Six	six	CD
cord-048466-fj9l8che	142	2	potential	potential	JJ
cord-048466-fj9l8che	142	3	N	n	CD
cord-048466-fj9l8che	142	4	-	-	HYPH
cord-048466-fj9l8che	142	5	glycosylation	glycosylation	NN
cord-048466-fj9l8che	142	6	sites	site	NNS
cord-048466-fj9l8che	142	7	have	have	VBP
cord-048466-fj9l8che	142	8	been	be	VBN
cord-048466-fj9l8che	142	9	conserved	conserve	VBN
cord-048466-fj9l8che	142	10	in	in	IN
cord-048466-fj9l8che	142	11	the	the	DT
cord-048466-fj9l8che	142	12	N2	N2	NNP
cord-048466-fj9l8che	142	13	NA	NA	NNP
cord-048466-fj9l8che	142	14	Danish	danish	JJ
cord-048466-fj9l8che	142	15	dataset	dataset	NN
cord-048466-fj9l8che	142	16	from	from	IN
cord-048466-fj9l8che	142	17	1999	1999	CD
cord-048466-fj9l8che	142	18	to	to	IN
cord-048466-fj9l8che	142	19	2003	2003	CD
cord-048466-fj9l8che	142	20	.	.	.
cord-048466-fj9l8che	143	1	The	the	DT
cord-048466-fj9l8che	143	2	majority	majority	NN
cord-048466-fj9l8che	143	3	of	of	IN
cord-048466-fj9l8che	143	4	isolates	isolate	NNS
cord-048466-fj9l8che	143	5	from	from	IN
cord-048466-fj9l8che	143	6	2003	2003	CD
cord-048466-fj9l8che	143	7	to	to	IN
cord-048466-fj9l8che	143	8	2006	2006	CD
cord-048466-fj9l8che	143	9	have	have	VBP
cord-048466-fj9l8che	143	10	lost	lose	VBN
cord-048466-fj9l8che	143	11	the	the	DT
cord-048466-fj9l8che	143	12	site	site	NN
cord-048466-fj9l8che	143	13	at	at	IN
cord-048466-fj9l8che	143	14	position	position	NN
cord-048466-fj9l8che	143	15	93	93	CD
cord-048466-fj9l8che	143	16	which	which	WDT
cord-048466-fj9l8che	143	17	is	be	VBZ
cord-048466-fj9l8che	143	18	located	locate	VBN
cord-048466-fj9l8che	143	19	in	in	IN
cord-048466-fj9l8che	143	20	a	a	DT
cord-048466-fj9l8che	143	21	CTL	CTL	NNP
cord-048466-fj9l8che	143	22	epitope	epitope	NN
cord-048466-fj9l8che	143	23	(	(	-LRB-
cord-048466-fj9l8che	143	24	HLA	HLA	NNP
cord-048466-fj9l8che	143	25	-	-	HYPH
cord-048466-fj9l8che	143	26	A*0201	A*0201	NNP
cord-048466-fj9l8che	143	27	)	)	-RRB-
cord-048466-fj9l8che	143	28	region	region	NN
cord-048466-fj9l8che	143	29	of	of	IN
cord-048466-fj9l8che	143	30	NA	NA	NNP
cord-048466-fj9l8che	143	31	[	[	-LRB-
cord-048466-fj9l8che	143	32	12	12	CD
cord-048466-fj9l8che	143	33	]	]	-RRB-
cord-048466-fj9l8che	143	34	.	.	.
cord-048466-fj9l8che	144	1	The	the	DT
cord-048466-fj9l8che	144	2	recent	recent	JJ
cord-048466-fj9l8che	144	3	NAs	na	NNS
cord-048466-fj9l8che	144	4	may	may	MD
cord-048466-fj9l8che	144	5	therefore	therefore	RB
cord-048466-fj9l8che	144	6	be	be	VB
cord-048466-fj9l8che	144	7	more	more	RBR
cord-048466-fj9l8che	144	8	easily	easily	RB
cord-048466-fj9l8che	144	9	recognised	recognise	VBN
cord-048466-fj9l8che	144	10	by	by	IN
cord-048466-fj9l8che	144	11	the	the	DT
cord-048466-fj9l8che	144	12	cytotoxic	cytotoxic	JJ
cord-048466-fj9l8che	144	13	immune	immune	JJ
cord-048466-fj9l8che	144	14	system	system	NN
cord-048466-fj9l8che	144	15	.	.	.
cord-048466-fj9l8che	145	1	We	-PRON-	PRP
cord-048466-fj9l8che	145	2	found	find	VBD
cord-048466-fj9l8che	145	3	two	two	CD
cord-048466-fj9l8che	145	4	predicted	predict	VBN
cord-048466-fj9l8che	145	5	N	n	NN
cord-048466-fj9l8che	145	6	-	-	HYPH
cord-048466-fj9l8che	145	7	glycosylation	glycosylation	NN
cord-048466-fj9l8che	145	8	sites	site	NNS
cord-048466-fj9l8che	145	9	(	(	-LRB-
cord-048466-fj9l8che	145	10	61	61	CD
cord-048466-fj9l8che	145	11	and	and	CC
cord-048466-fj9l8che	145	12	70	70	CD
cord-048466-fj9l8che	145	13	)	)	-RRB-
cord-048466-fj9l8che	145	14	in	in	IN
cord-048466-fj9l8che	145	15	the	the	DT
cord-048466-fj9l8che	145	16	N2	N2	NNP
cord-048466-fj9l8che	145	17	NA	NA	NNP
cord-048466-fj9l8che	145	18	stalk	stalk	VB
cord-048466-fj9l8che	145	19	region	region	NN
cord-048466-fj9l8che	145	20	in	in	IN
cord-048466-fj9l8che	145	21	sequences	sequence	NNS
cord-048466-fj9l8che	145	22	from	from	IN
cord-048466-fj9l8che	145	23	1999	1999	CD
cord-048466-fj9l8che	145	24	-	-	SYM
cord-048466-fj9l8che	145	25	2006	2006	CD
cord-048466-fj9l8che	145	26	.	.	.
cord-048466-fj9l8che	146	1	Greater	great	JJR
cord-048466-fj9l8che	146	2	density	density	NN
cord-048466-fj9l8che	146	3	of	of	IN
cord-048466-fj9l8che	146	4	carbohydrate	carbohydrate	NN
cord-048466-fj9l8che	146	5	in	in	IN
cord-048466-fj9l8che	146	6	the	the	DT
cord-048466-fj9l8che	146	7	stalk	stalk	NN
cord-048466-fj9l8che	146	8	region	region	NN
cord-048466-fj9l8che	146	9	of	of	IN
cord-048466-fj9l8che	146	10	NA	NA	NNP
cord-048466-fj9l8che	146	11	might	may	MD
cord-048466-fj9l8che	146	12	reflect	reflect	VB
cord-048466-fj9l8che	146	13	a	a	DT
cord-048466-fj9l8che	146	14	need	need	NN
cord-048466-fj9l8che	146	15	for	for	IN
cord-048466-fj9l8che	146	16	proteolytic	proteolytic	JJ
cord-048466-fj9l8che	146	17	protection	protection	NN
cord-048466-fj9l8che	146	18	.	.	.
cord-048466-fj9l8che	147	1	The	the	DT
cord-048466-fj9l8che	147	2	two	two	CD
cord-048466-fj9l8che	147	3	observed	observe	VBD
cord-048466-fj9l8che	147	4	carbohydrates	carbohydrate	NNS
cord-048466-fj9l8che	147	5	in	in	IN
cord-048466-fj9l8che	147	6	the	the	DT
cord-048466-fj9l8che	147	7	stalk	stalk	NN
cord-048466-fj9l8che	147	8	have	have	VBP
cord-048466-fj9l8che	147	9	been	be	VBN
cord-048466-fj9l8che	147	10	reported	report	VBN
cord-048466-fj9l8che	147	11	for	for	IN
cord-048466-fj9l8che	147	12	other	other	JJ
cord-048466-fj9l8che	147	13	isolates	isolate	NNS
cord-048466-fj9l8che	147	14	in	in	IN
cord-048466-fj9l8che	147	15	other	other	JJ
cord-048466-fj9l8che	147	16	time	time	NN
cord-048466-fj9l8che	147	17	periods	period	NNS
cord-048466-fj9l8che	147	18	and	and	CC
cord-048466-fj9l8che	147	19	other	other	JJ
cord-048466-fj9l8che	147	20	continents	continent	NNS
cord-048466-fj9l8che	147	21	[	[	-LRB-
cord-048466-fj9l8che	147	22	58	58	CD
cord-048466-fj9l8che	147	23	,	,	,
cord-048466-fj9l8che	147	24	60	60	CD
cord-048466-fj9l8che	147	25	]	]	-RRB-
cord-048466-fj9l8che	147	26	.	.	.
cord-048466-fj9l8che	148	1	The	the	DT
cord-048466-fj9l8che	148	2	stalk	stalk	NN
cord-048466-fj9l8che	148	3	region	region	NN
cord-048466-fj9l8che	148	4	has	have	VBZ
cord-048466-fj9l8che	148	5	therefore	therefore	RB
cord-048466-fj9l8che	148	6	stayed	stay	VBN
cord-048466-fj9l8che	148	7	unchanged	unchanged	JJ
cord-048466-fj9l8che	148	8	and	and	CC
cord-048466-fj9l8che	148	9	the	the	DT
cord-048466-fj9l8che	148	10	two	two	CD
cord-048466-fj9l8che	148	11	sequons	sequon	NNS
cord-048466-fj9l8che	148	12	seem	seem	VBP
cord-048466-fj9l8che	148	13	to	to	TO
cord-048466-fj9l8che	148	14	be	be	VB
cord-048466-fj9l8che	148	15	conserved	conserve	VBN
cord-048466-fj9l8che	148	16	.	.	.
cord-048466-fj9l8che	149	1	As	as	IN
cord-048466-fj9l8che	149	2	expected	expect	VBN
cord-048466-fj9l8che	149	3	a	a	DT
cord-048466-fj9l8che	149	4	higher	high	JJR
cord-048466-fj9l8che	149	5	dN	dN	NNP
cord-048466-fj9l8che	149	6	/	/	SYM
cord-048466-fj9l8che	149	7	dS	ds	NN
cord-048466-fj9l8che	149	8	ratio	ratio	NN
cord-048466-fj9l8che	149	9	was	be	VBD
cord-048466-fj9l8che	149	10	observed	observe	VBN
cord-048466-fj9l8che	149	11	for	for	IN
cord-048466-fj9l8che	149	12	the	the	DT
cord-048466-fj9l8che	149	13	surface	surface	NN
cord-048466-fj9l8che	149	14	glycoproteins	glycoprotein	NNS
cord-048466-fj9l8che	149	15	,	,	,
cord-048466-fj9l8che	149	16	although	although	IN
cord-048466-fj9l8che	149	17	none	none	NN
cord-048466-fj9l8che	149	18	were	be	VBD
cord-048466-fj9l8che	149	19	directly	directly	RB
cord-048466-fj9l8che	149	20	influenced	influence	VBN
cord-048466-fj9l8che	149	21	by	by	IN
cord-048466-fj9l8che	149	22	positive	positive	JJ
cord-048466-fj9l8che	149	23	selection	selection	NN
cord-048466-fj9l8che	149	24	.	.	.
cord-048466-fj9l8che	150	1	We	-PRON-	PRP
cord-048466-fj9l8che	150	2	observed	observe	VBD
cord-048466-fj9l8che	150	3	that	that	IN
cord-048466-fj9l8che	150	4	the	the	DT
cord-048466-fj9l8che	150	5	HA1	HA1	NNP
cord-048466-fj9l8che	150	6	region	region	NN
cord-048466-fj9l8che	150	7	and	and	CC
cord-048466-fj9l8che	150	8	the	the	DT
cord-048466-fj9l8che	150	9	M2	M2	NNP
cord-048466-fj9l8che	150	10	protein	protein	NN
cord-048466-fj9l8che	150	11	have	have	VBP
cord-048466-fj9l8che	150	12	a	a	DT
cord-048466-fj9l8che	150	13	slightly	slightly	RB
cord-048466-fj9l8che	150	14	higher	high	JJR
cord-048466-fj9l8che	150	15	global	global	JJ
cord-048466-fj9l8che	150	16	dN	dN	NNP
cord-048466-fj9l8che	150	17	/	/	SYM
cord-048466-fj9l8che	150	18	dS	dS	NNP
cord-048466-fj9l8che	150	19	ratio	ratio	NN
cord-048466-fj9l8che	150	20	than	than	IN
cord-048466-fj9l8che	150	21	the	the	DT
cord-048466-fj9l8che	150	22	other	other	JJ
cord-048466-fj9l8che	150	23	genes	gene	NNS
cord-048466-fj9l8che	150	24	(	(	-LRB-
cord-048466-fj9l8che	150	25	Table	Table	NNP
cord-048466-fj9l8che	150	26	3	3	CD
cord-048466-fj9l8che	150	27	)	)	-RRB-
cord-048466-fj9l8che	150	28	.	.	.
cord-048466-fj9l8che	151	1	This	this	DT
cord-048466-fj9l8che	151	2	is	be	VBZ
cord-048466-fj9l8che	151	3	consistent	consistent	JJ
cord-048466-fj9l8che	151	4	with	with	IN
cord-048466-fj9l8che	151	5	the	the	DT
cord-048466-fj9l8che	151	6	findings	finding	NNS
cord-048466-fj9l8che	151	7	of	of	IN
cord-048466-fj9l8che	151	8	others	other	NNS
cord-048466-fj9l8che	151	9	[	[	-LRB-
cord-048466-fj9l8che	151	10	11	11	CD
cord-048466-fj9l8che	151	11	,	,	,
cord-048466-fj9l8che	151	12	61	61	CD
cord-048466-fj9l8che	151	13	]	]	-RRB-
cord-048466-fj9l8che	151	14	.	.	.
cord-048466-fj9l8che	152	1	The	the	DT
cord-048466-fj9l8che	152	2	M2	M2	NNP
cord-048466-fj9l8che	152	3	protein	protein	NN
cord-048466-fj9l8che	152	4	is	be	VBZ
cord-048466-fj9l8che	152	5	a	a	DT
cord-048466-fj9l8che	152	6	membrane	membrane	NN
cord-048466-fj9l8che	152	7	ion	ion	NN
cord-048466-fj9l8che	152	8	channel	channel	NN
cord-048466-fj9l8che	152	9	protein	protein	NN
cord-048466-fj9l8che	152	10	on	on	IN
cord-048466-fj9l8che	152	11	the	the	DT
cord-048466-fj9l8che	152	12	surface	surface	NN
cord-048466-fj9l8che	152	13	of	of	IN
cord-048466-fj9l8che	152	14	the	the	DT
cord-048466-fj9l8che	152	15	virus	virus	NN
cord-048466-fj9l8che	152	16	molecule	molecule	NN
cord-048466-fj9l8che	152	17	,	,	,
cord-048466-fj9l8che	152	18	a	a	DT
cord-048466-fj9l8che	152	19	higher	high	JJR
cord-048466-fj9l8che	152	20	dN	dN	NNP
cord-048466-fj9l8che	152	21	/	/	SYM
cord-048466-fj9l8che	152	22	dS	ds	NN
cord-048466-fj9l8che	152	23	ratio	ratio	NN
cord-048466-fj9l8che	152	24	for	for	IN
cord-048466-fj9l8che	152	25	this	this	DT
cord-048466-fj9l8che	152	26	protein	protein	NN
cord-048466-fj9l8che	152	27	compared	compare	VBN
cord-048466-fj9l8che	152	28	to	to	IN
cord-048466-fj9l8che	152	29	the	the	DT
cord-048466-fj9l8che	152	30	internal	internal	JJ
cord-048466-fj9l8che	152	31	proteins	protein	NNS
cord-048466-fj9l8che	152	32	is	be	VBZ
cord-048466-fj9l8che	152	33	expected	expect	VBN
cord-048466-fj9l8che	152	34	.	.	.
cord-048466-fj9l8che	153	1	The	the	DT
cord-048466-fj9l8che	153	2	ratio	ratio	NN
cord-048466-fj9l8che	153	3	might	may	MD
cord-048466-fj9l8che	153	4	,	,	,
cord-048466-fj9l8che	153	5	however	however	RB
cord-048466-fj9l8che	153	6	,	,	,
cord-048466-fj9l8che	153	7	be	be	VB
cord-048466-fj9l8che	153	8	biased	bias	VBN
cord-048466-fj9l8che	153	9	because	because	IN
cord-048466-fj9l8che	153	10	the	the	DT
cord-048466-fj9l8che	153	11	M2	M2	NNP
cord-048466-fj9l8che	153	12	protein	protein	NN
cord-048466-fj9l8che	153	13	is	be	VBZ
cord-048466-fj9l8che	153	14	spliced	splice	VBN
cord-048466-fj9l8che	153	15	from	from	IN
cord-048466-fj9l8che	153	16	M	M	NNP
cord-048466-fj9l8che	153	17	and	and	CC
cord-048466-fj9l8che	153	18	the	the	DT
cord-048466-fj9l8che	153	19	dS	dS	NNP
cord-048466-fj9l8che	153	20	is	be	VBZ
cord-048466-fj9l8che	153	21	suppressed	suppress	VBN
cord-048466-fj9l8che	153	22	for	for	IN
cord-048466-fj9l8che	153	23	overlapping	overlap	VBG
cord-048466-fj9l8che	153	24	regions	region	NNS
cord-048466-fj9l8che	153	25	giving	give	VBG
cord-048466-fj9l8che	153	26	a	a	DT
cord-048466-fj9l8che	153	27	higher	high	JJR
cord-048466-fj9l8che	153	28	dN	dN	NNP
cord-048466-fj9l8che	153	29	/	/	SYM
cord-048466-fj9l8che	153	30	dS	ds	NN
cord-048466-fj9l8che	153	31	ratio	ratio	NN
cord-048466-fj9l8che	153	32	[	[	-LRB-
cord-048466-fj9l8che	153	33	11	11	CD
cord-048466-fj9l8che	153	34	]	]	-RRB-
cord-048466-fj9l8che	153	35	.	.	.
cord-048466-fj9l8che	154	1	Earlier	early	JJR
cord-048466-fj9l8che	154	2	findings	finding	NNS
cord-048466-fj9l8che	154	3	support	support	VBP
cord-048466-fj9l8che	154	4	positive	positive	JJ
cord-048466-fj9l8che	154	5	selection	selection	NN
cord-048466-fj9l8che	154	6	at	at	IN
cord-048466-fj9l8che	154	7	sites	site	NNS
cord-048466-fj9l8che	154	8	involved	involve	VBN
cord-048466-fj9l8che	154	9	in	in	IN
cord-048466-fj9l8che	154	10	receptor	receptor	NN
cord-048466-fj9l8che	154	11	and	and	CC
cord-048466-fj9l8che	154	12	antigen	antigen	NN
cord-048466-fj9l8che	154	13	binding	bind	VBG
cord-048466-fj9l8che	154	14	[	[	-LRB-
cord-048466-fj9l8che	154	15	11	11	CD
cord-048466-fj9l8che	154	16	,	,	,
cord-048466-fj9l8che	154	17	62	62	CD
cord-048466-fj9l8che	154	18	]	]	-RRB-
cord-048466-fj9l8che	154	19	.	.	.
cord-048466-fj9l8che	155	1	Five	five	CD
cord-048466-fj9l8che	155	2	of	of	IN
cord-048466-fj9l8che	155	3	the	the	DT
cord-048466-fj9l8che	155	4	18	18	CD
cord-048466-fj9l8che	155	5	codons	codon	NNS
cord-048466-fj9l8che	155	6	in	in	IN
cord-048466-fj9l8che	155	7	HA	HA	NNP
cord-048466-fj9l8che	155	8	proposed	propose	VBN
cord-048466-fj9l8che	155	9	by	by	IN
cord-048466-fj9l8che	155	10	Bush	Bush	NNP
cord-048466-fj9l8che	155	11	et	et	NNP
cord-048466-fj9l8che	155	12	al	al	NNP
cord-048466-fj9l8che	155	13	.	.	NNP
cord-048466-fj9l8che	155	14	,	,	,
cord-048466-fj9l8che	155	15	[	[	-LRB-
cord-048466-fj9l8che	155	16	63	63	CD
cord-048466-fj9l8che	155	17	]	]	-RRB-
cord-048466-fj9l8che	155	18	to	to	TO
cord-048466-fj9l8che	155	19	be	be	VB
cord-048466-fj9l8che	155	20	under	under	IN
cord-048466-fj9l8che	155	21	positive	positive	JJ
cord-048466-fj9l8che	155	22	selection	selection	NN
cord-048466-fj9l8che	155	23	were	be	VBD
cord-048466-fj9l8che	155	24	found	find	VBN
cord-048466-fj9l8che	155	25	to	to	TO
cord-048466-fj9l8che	155	26	have	have	VB
cord-048466-fj9l8che	155	27	changed	change	VBN
cord-048466-fj9l8che	155	28	in	in	IN
cord-048466-fj9l8che	155	29	our	-PRON-	PRP$
cord-048466-fj9l8che	155	30	HA	HA	NNP
cord-048466-fj9l8che	155	31	dataset	dataset	NN
cord-048466-fj9l8che	155	32	of	of	IN
cord-048466-fj9l8che	155	33	H3N2	H3N2	NNP
cord-048466-fj9l8che	155	34	since	since	IN
cord-048466-fj9l8che	155	35	1999	1999	CD
cord-048466-fj9l8che	155	36	,	,	,
cord-048466-fj9l8che	155	37	namely	namely	RB
cord-048466-fj9l8che	155	38	:	:	:
cord-048466-fj9l8che	155	39	pos	pos	NNP
cord-048466-fj9l8che	155	40	145	145	CD
cord-048466-fj9l8che	155	41	,	,	,
cord-048466-fj9l8che	155	42	156	156	CD
cord-048466-fj9l8che	155	43	,	,	,
cord-048466-fj9l8che	155	44	186	186	CD
cord-048466-fj9l8che	155	45	,	,	,
cord-048466-fj9l8che	155	46	193	193	CD
cord-048466-fj9l8che	155	47	and	and	CC
cord-048466-fj9l8che	155	48	226	226	CD
cord-048466-fj9l8che	155	49	.	.	.
cord-048466-fj9l8che	156	1	In	in	IN
cord-048466-fj9l8che	156	2	our	-PRON-	PRP$
cord-048466-fj9l8che	156	3	H3	H3	NNP
cord-048466-fj9l8che	156	4	dataset	dataset	NN
cord-048466-fj9l8che	156	5	(	(	-LRB-
cord-048466-fj9l8che	156	6	n	n	NN
cord-048466-fj9l8che	156	7	=	=	SYM
cord-048466-fj9l8che	156	8	204	204	CD
cord-048466-fj9l8che	156	9	)	)	-RRB-
cord-048466-fj9l8che	156	10	site	site	NN
cord-048466-fj9l8che	156	11	199	199	CD
cord-048466-fj9l8che	156	12	was	be	VBD
cord-048466-fj9l8che	156	13	influenced	influence	VBN
cord-048466-fj9l8che	156	14	by	by	IN
cord-048466-fj9l8che	156	15	positive	positive	JJ
cord-048466-fj9l8che	156	16	selection	selection	NN
cord-048466-fj9l8che	156	17	as	as	IN
cord-048466-fj9l8che	156	18	calculated	calculate	VBN
cord-048466-fj9l8che	156	19	by	by	IN
cord-048466-fj9l8che	156	20	FEL	FEL	NNP
cord-048466-fj9l8che	156	21	analysis	analysis	NN
cord-048466-fj9l8che	156	22	,	,	,
cord-048466-fj9l8che	156	23	but	but	CC
cord-048466-fj9l8che	156	24	no	no	DT
cord-048466-fj9l8che	156	25	positively	positively	RB
cord-048466-fj9l8che	156	26	selected	select	VBN
cord-048466-fj9l8che	156	27	sites	site	NNS
cord-048466-fj9l8che	156	28	were	be	VBD
cord-048466-fj9l8che	156	29	found	find	VBN
cord-048466-fj9l8che	156	30	applying	apply	VBG
cord-048466-fj9l8che	156	31	the	the	DT
cord-048466-fj9l8che	156	32	more	more	RBR
cord-048466-fj9l8che	156	33	conservative	conservative	JJ
cord-048466-fj9l8che	156	34	SLAC	SLAC	NNP
cord-048466-fj9l8che	156	35	method	method	NN
cord-048466-fj9l8che	156	36	.	.	.
cord-048466-fj9l8che	157	1	Position	position	NN
cord-048466-fj9l8che	157	2	199	199	CD
cord-048466-fj9l8che	157	3	may	may	MD
cord-048466-fj9l8che	157	4	be	be	VB
cord-048466-fj9l8che	157	5	involved	involve	VBN
cord-048466-fj9l8che	157	6	in	in	IN
cord-048466-fj9l8che	157	7	receptor	receptor	NN
cord-048466-fj9l8che	157	8	binding	binding	NN
cord-048466-fj9l8che	157	9	and	and	CC
cord-048466-fj9l8che	157	10	influence	influence	NN
cord-048466-fj9l8che	157	11	on	on	IN
cord-048466-fj9l8che	157	12	the	the	DT
cord-048466-fj9l8che	157	13	virus	virus	NN
cord-048466-fj9l8che	157	14	ability	ability	NN
cord-048466-fj9l8che	157	15	to	to	TO
cord-048466-fj9l8che	157	16	grow	grow	VB
cord-048466-fj9l8che	157	17	in	in	IN
cord-048466-fj9l8che	157	18	eggs	egg	NNS
cord-048466-fj9l8che	157	19	[	[	-LRB-
cord-048466-fj9l8che	157	20	10	10	CD
cord-048466-fj9l8che	157	21	]	]	-RRB-
cord-048466-fj9l8che	157	22	.	.	.
cord-048466-fj9l8che	158	1	In	in	IN
cord-048466-fj9l8che	158	2	a	a	DT
cord-048466-fj9l8che	158	3	similar	similar	JJ
cord-048466-fj9l8che	158	4	study	study	NN
cord-048466-fj9l8che	158	5	on	on	IN
cord-048466-fj9l8che	158	6	a	a	DT
cord-048466-fj9l8che	158	7	slightly	slightly	RB
cord-048466-fj9l8che	158	8	larger	large	JJR
cord-048466-fj9l8che	158	9	dataset	dataset	NN
cord-048466-fj9l8che	158	10	(	(	-LRB-
cord-048466-fj9l8che	158	11	n	n	NN
cord-048466-fj9l8che	158	12	=	=	SYM
cord-048466-fj9l8che	158	13	284	284	CD
cord-048466-fj9l8che	158	14	)	)	-RRB-
cord-048466-fj9l8che	158	15	positions	position	VBZ
cord-048466-fj9l8che	158	16	220	220	CD
cord-048466-fj9l8che	158	17	and	and	CC
cord-048466-fj9l8che	158	18	229	229	CD
cord-048466-fj9l8che	158	19	were	be	VBD
cord-048466-fj9l8che	158	20	found	find	VBN
cord-048466-fj9l8che	158	21	to	to	TO
cord-048466-fj9l8che	158	22	be	be	VB
cord-048466-fj9l8che	158	23	positively	positively	RB
cord-048466-fj9l8che	158	24	selected	select	VBN
cord-048466-fj9l8che	158	25	[	[	-LRB-
cord-048466-fj9l8che	158	26	11	11	CD
cord-048466-fj9l8che	158	27	]	]	-RRB-
cord-048466-fj9l8che	158	28	.	.	.
cord-048466-fj9l8che	159	1	Another	another	DT
cord-048466-fj9l8che	159	2	study	study	NN
cord-048466-fj9l8che	159	3	found	find	VBD
cord-048466-fj9l8che	159	4	positions	position	NNS
cord-048466-fj9l8che	159	5	13	13	CD
cord-048466-fj9l8che	159	6	and	and	CC
cord-048466-fj9l8che	159	7	236	236	CD
cord-048466-fj9l8che	159	8	[	[	-LRB-
cord-048466-fj9l8che	159	9	62	62	CD
cord-048466-fj9l8che	159	10	]	]	-RRB-
cord-048466-fj9l8che	159	11	;	;	:
cord-048466-fj9l8che	159	12	however	however	RB
cord-048466-fj9l8che	159	13	,	,	,
cord-048466-fj9l8che	159	14	suggested	suggest	VBD
cord-048466-fj9l8che	159	15	positively	positively	RB
cord-048466-fj9l8che	159	16	selected	select	VBN
cord-048466-fj9l8che	159	17	sites	site	NNS
cord-048466-fj9l8che	159	18	may	may	MD
cord-048466-fj9l8che	159	19	vary	vary	VB
cord-048466-fj9l8che	159	20	by	by	IN
cord-048466-fj9l8che	159	21	the	the	DT
cord-048466-fj9l8che	159	22	dataset	dataset	NN
cord-048466-fj9l8che	159	23	applied	apply	VBN
cord-048466-fj9l8che	159	24	,	,	,
cord-048466-fj9l8che	159	25	method	method	NN
cord-048466-fj9l8che	159	26	used	use	VBN
cord-048466-fj9l8che	159	27	and	and	CC
cord-048466-fj9l8che	159	28	the	the	DT
cord-048466-fj9l8che	159	29	significance	significance	NN
cord-048466-fj9l8che	159	30	level	level	NN
cord-048466-fj9l8che	159	31	selected	select	VBN
cord-048466-fj9l8che	159	32	for	for	IN
cord-048466-fj9l8che	159	33	a	a	DT
cord-048466-fj9l8che	159	34	site	site	NN
cord-048466-fj9l8che	159	35	to	to	TO
cord-048466-fj9l8che	159	36	be	be	VB
cord-048466-fj9l8che	159	37	classified	classify	VBN
cord-048466-fj9l8che	159	38	as	as	RB
cord-048466-fj9l8che	159	39	positively	positively	RB
cord-048466-fj9l8che	159	40	selected	select	VBN
cord-048466-fj9l8che	159	41	.	.	.
cord-048466-fj9l8che	160	1	REL	REL	NNP
cord-048466-fj9l8che	160	2	analysis	analysis	NN
cord-048466-fj9l8che	160	3	identified	identify	VBD
cord-048466-fj9l8che	160	4	four	four	CD
cord-048466-fj9l8che	160	5	sites	site	NNS
cord-048466-fj9l8che	160	6	(	(	-LRB-
cord-048466-fj9l8che	160	7	208	208	CD
cord-048466-fj9l8che	160	8	,	,	,
cord-048466-fj9l8che	160	9	211	211	CD
cord-048466-fj9l8che	160	10	,	,	,
cord-048466-fj9l8che	160	11	218	218	CD
cord-048466-fj9l8che	160	12	and	and	CC
cord-048466-fj9l8che	160	13	219	219	CD
cord-048466-fj9l8che	160	14	)	)	-RRB-
cord-048466-fj9l8che	160	15	in	in	IN
cord-048466-fj9l8che	160	16	M1	M1	NNP
cord-048466-fj9l8che	160	17	under	under	IN
cord-048466-fj9l8che	160	18	positive	positive	JJ
cord-048466-fj9l8che	160	19	selection	selection	NN
cord-048466-fj9l8che	160	20	pressure	pressure	NN
cord-048466-fj9l8che	160	21	.	.	.
cord-048466-fj9l8che	161	1	REL	REL	NNP
cord-048466-fj9l8che	161	2	analysis	analysis	NN
cord-048466-fj9l8che	161	3	tends	tend	VBZ
cord-048466-fj9l8che	161	4	to	to	TO
cord-048466-fj9l8che	161	5	give	give	VB
cord-048466-fj9l8che	161	6	better	well	JJR
cord-048466-fj9l8che	161	7	estimates	estimate	NNS
cord-048466-fj9l8che	161	8	on	on	IN
cord-048466-fj9l8che	161	9	small	small	JJ
cord-048466-fj9l8che	161	10	datasets	dataset	NNS
cord-048466-fj9l8che	161	11	than	than	IN
cord-048466-fj9l8che	161	12	SLAC	SLAC	NNP
cord-048466-fj9l8che	161	13	and	and	CC
cord-048466-fj9l8che	161	14	FEL	FEL	NNP
cord-048466-fj9l8che	161	15	.	.	.
cord-048466-fj9l8che	162	1	Sites	site	NNS
cord-048466-fj9l8che	162	2	211	211	CD
cord-048466-fj9l8che	162	3	,	,	,
cord-048466-fj9l8che	162	4	218	218	CD
cord-048466-fj9l8che	162	5	,	,	,
cord-048466-fj9l8che	162	6	and	and	CC
cord-048466-fj9l8che	162	7	219	219	CD
cord-048466-fj9l8che	162	8	were	be	VBD
cord-048466-fj9l8che	162	9	still	still	RB
cord-048466-fj9l8che	162	10	selected	select	VBN
cord-048466-fj9l8che	162	11	when	when	WRB
cord-048466-fj9l8che	162	12	the	the	DT
cord-048466-fj9l8che	162	13	bayes	bayes	NNP
cord-048466-fj9l8che	162	14	factor	factor	NN
cord-048466-fj9l8che	162	15	cut	cut	VBD
cord-048466-fj9l8che	162	16	-	-	HYPH
cord-048466-fj9l8che	162	17	off	off	NN
cord-048466-fj9l8che	162	18	was	be	VBD
cord-048466-fj9l8che	162	19	increased	increase	VBN
cord-048466-fj9l8che	162	20	from	from	IN
cord-048466-fj9l8che	162	21	50	50	CD
cord-048466-fj9l8che	162	22	to	to	IN
cord-048466-fj9l8che	162	23	200	200	CD
cord-048466-fj9l8che	162	24	.	.	.
cord-048466-fj9l8che	163	1	Further	further	JJ
cord-048466-fj9l8che	163	2	analysis	analysis	NN
cord-048466-fj9l8che	163	3	would	would	MD
cord-048466-fj9l8che	163	4	be	be	VB
cord-048466-fj9l8che	163	5	needed	need	VBN
cord-048466-fj9l8che	163	6	to	to	TO
cord-048466-fj9l8che	163	7	determine	determine	VB
cord-048466-fj9l8che	163	8	if	if	IN
cord-048466-fj9l8che	163	9	these	these	DT
cord-048466-fj9l8che	163	10	sites	site	NNS
cord-048466-fj9l8che	163	11	actually	actually	RB
cord-048466-fj9l8che	163	12	are	be	VBP
cord-048466-fj9l8che	163	13	positively	positively	RB
cord-048466-fj9l8che	163	14	selected	select	VBN
cord-048466-fj9l8che	163	15	.	.	.
cord-048466-fj9l8che	164	1	There	there	EX
cord-048466-fj9l8che	164	2	is	be	VBZ
cord-048466-fj9l8che	164	3	a	a	DT
cord-048466-fj9l8che	164	4	need	need	NN
cord-048466-fj9l8che	164	5	for	for	IN
cord-048466-fj9l8che	164	6	complete	complete	JJ
cord-048466-fj9l8che	164	7	genome	genome	NN
cord-048466-fj9l8che	164	8	analysis	analysis	NN
cord-048466-fj9l8che	164	9	of	of	IN
cord-048466-fj9l8che	164	10	European	european	JJ
cord-048466-fj9l8che	164	11	human	human	JJ
cord-048466-fj9l8che	164	12	influenza	influenza	NN
cord-048466-fj9l8che	164	13	A	a	DT
cord-048466-fj9l8che	164	14	viruses	virus	NNS
cord-048466-fj9l8che	164	15	in	in	IN
cord-048466-fj9l8che	164	16	order	order	NN
cord-048466-fj9l8che	164	17	to	to	TO
cord-048466-fj9l8che	164	18	gather	gather	VB
cord-048466-fj9l8che	164	19	a	a	DT
cord-048466-fj9l8che	164	20	comprehensive	comprehensive	JJ
cord-048466-fj9l8che	164	21	picture	picture	NN
cord-048466-fj9l8che	164	22	of	of	IN
cord-048466-fj9l8che	164	23	the	the	DT
cord-048466-fj9l8che	164	24	evolution	evolution	NN
cord-048466-fj9l8che	164	25	and	and	CC
cord-048466-fj9l8che	164	26	migration	migration	NN
cord-048466-fj9l8che	164	27	of	of	IN
cord-048466-fj9l8che	164	28	viruses	virus	NNS
cord-048466-fj9l8che	164	29	.	.	.
cord-048466-fj9l8che	165	1	Our	-PRON-	PRP$
cord-048466-fj9l8che	165	2	results	result	NNS
cord-048466-fj9l8che	165	3	support	support	VBP
cord-048466-fj9l8che	165	4	the	the	DT
cord-048466-fj9l8che	165	5	suggestion	suggestion	NN
cord-048466-fj9l8che	165	6	that	that	IN
cord-048466-fj9l8che	165	7	the	the	DT
cord-048466-fj9l8che	165	8	evolution	evolution	NN
cord-048466-fj9l8che	165	9	of	of	IN
cord-048466-fj9l8che	165	10	influenza	influenza	NN
cord-048466-fj9l8che	165	11	A	a	DT
cord-048466-fj9l8che	165	12	viruses	virus	NNS
cord-048466-fj9l8che	165	13	is	be	VBZ
cord-048466-fj9l8che	165	14	more	more	RBR
cord-048466-fj9l8che	165	15	complex	complex	JJ
cord-048466-fj9l8che	165	16	than	than	IN
cord-048466-fj9l8che	165	17	originally	originally	RB
cord-048466-fj9l8che	165	18	believed	believe	VBN
cord-048466-fj9l8che	165	19	[	[	-LRB-
cord-048466-fj9l8che	165	20	28	28	CD
cord-048466-fj9l8che	165	21	,	,	,
cord-048466-fj9l8che	165	22	62	62	CD
cord-048466-fj9l8che	165	23	]	]	-RRB-
cord-048466-fj9l8che	165	24	.	.	.
cord-048466-fj9l8che	166	1	Local	local	JJ
cord-048466-fj9l8che	166	2	short	short	JJ
cord-048466-fj9l8che	166	3	term	term	NN
cord-048466-fj9l8che	166	4	evolution	evolution	NN
cord-048466-fj9l8che	166	5	of	of	IN
cord-048466-fj9l8che	166	6	influenza	influenza	NN
cord-048466-fj9l8che	166	7	virus	virus	NN
cord-048466-fj9l8che	166	8	is	be	VBZ
cord-048466-fj9l8che	166	9	a	a	DT
cord-048466-fj9l8che	166	10	stochastic	stochastic	JJ
cord-048466-fj9l8che	166	11	process	process	NN
cord-048466-fj9l8che	166	12	,	,	,
cord-048466-fj9l8che	166	13	also	also	RB
cord-048466-fj9l8che	166	14	involving	involve	VBG
cord-048466-fj9l8che	166	15	gene	gene	NN
cord-048466-fj9l8che	166	16	reassortments	reassortment	NNS
cord-048466-fj9l8che	166	17	.	.	.
cord-048466-fj9l8che	167	1	It	-PRON-	PRP
cord-048466-fj9l8che	167	2	will	will	MD
cord-048466-fj9l8che	167	3	be	be	VB
cord-048466-fj9l8che	167	4	interesting	interesting	JJ
cord-048466-fj9l8che	167	5	to	to	TO
cord-048466-fj9l8che	167	6	further	further	RB
cord-048466-fj9l8che	167	7	investigate	investigate	VB
cord-048466-fj9l8che	167	8	how	how	WRB
cord-048466-fj9l8che	167	9	viruses	virus	NNS
cord-048466-fj9l8che	167	10	from	from	IN
cord-048466-fj9l8che	167	11	other	other	JJ
cord-048466-fj9l8che	167	12	parts	part	NNS
cord-048466-fj9l8che	167	13	of	of	IN
cord-048466-fj9l8che	167	14	Europe	Europe	NNP
cord-048466-fj9l8che	167	15	influence	influence	NN
cord-048466-fj9l8che	167	16	on	on	IN
cord-048466-fj9l8che	167	17	the	the	DT
cord-048466-fj9l8che	167	18	evolu	evolu	NN
cord-048466-fj9l8che	167	19	-	-	HYPH
cord-048466-fj9l8che	167	20	tion	tion	NN
cord-048466-fj9l8che	167	21	of	of	IN
cord-048466-fj9l8che	167	22	Danish	danish	JJ
cord-048466-fj9l8che	167	23	isolates	isolate	NNS
cord-048466-fj9l8che	167	24	when	when	WRB
cord-048466-fj9l8che	167	25	more	more	RBR
cord-048466-fj9l8che	167	26	full	full	JJ
cord-048466-fj9l8che	167	27	length	length	NN
cord-048466-fj9l8che	167	28	sequences	sequence	NNS
cord-048466-fj9l8che	167	29	from	from	IN
cord-048466-fj9l8che	167	30	Europe	Europe	NNP
cord-048466-fj9l8che	167	31	are	be	VBP
cord-048466-fj9l8che	167	32	made	make	VBN
cord-048466-fj9l8che	167	33	public	public	JJ
cord-048466-fj9l8che	167	34	.	.	.
cord-048466-fj9l8che	167	35	 	 	_SP
cord-048466-fj9l8che	168	1	Viral	Viral	NNP
cord-048466-fj9l8che	168	2	RNA	RNA	NNP
cord-048466-fj9l8che	168	3	was	be	VBD
cord-048466-fj9l8che	168	4	extracted	extract	VBN
cord-048466-fj9l8che	168	5	from	from	IN
cord-048466-fj9l8che	168	6	140	140	CD
cord-048466-fj9l8che	168	7	µl	µl	IN
cord-048466-fj9l8che	168	8	of	of	IN
cord-048466-fj9l8che	168	9	human	human	JJ
cord-048466-fj9l8che	168	10	nasal	nasal	NN
cord-048466-fj9l8che	168	11	swab	swab	NN
cord-048466-fj9l8che	168	12	suspension	suspension	NN
cord-048466-fj9l8che	168	13	or	or	CC
cord-048466-fj9l8che	168	14	nasopharyngeal	nasopharyngeal	JJ
cord-048466-fj9l8che	168	15	aspirate	aspirate	NN
cord-048466-fj9l8che	168	16	by	by	IN
cord-048466-fj9l8che	168	17	QIAamp	QIAamp	NNP
cord-048466-fj9l8che	169	1	®	®	.
cord-048466-fj9l8che	170	1	Viral	Viral	NNP
cord-048466-fj9l8che	170	2	RNA	RNA	NNP
cord-048466-fj9l8che	170	3	Mini	Mini	NNP
cord-048466-fj9l8che	170	4	Kit	Kit	NNP
cord-048466-fj9l8che	170	5	(	(	-LRB-
cord-048466-fj9l8che	170	6	QIAGEN	QIAGEN	NNP
cord-048466-fj9l8che	170	7	,	,	,
cord-048466-fj9l8che	170	8	Germany	Germany	NNP
cord-048466-fj9l8che	170	9	)	)	-RRB-
cord-048466-fj9l8che	170	10	as	as	IN
cord-048466-fj9l8che	170	11	described	describe	VBN
cord-048466-fj9l8che	170	12	by	by	IN
cord-048466-fj9l8che	170	13	the	the	DT
cord-048466-fj9l8che	170	14	manufacturer	manufacturer	NN
cord-048466-fj9l8che	170	15	or	or	CC
cord-048466-fj9l8che	170	16	by	by	IN
cord-048466-fj9l8che	170	17	an	an	DT
cord-048466-fj9l8che	170	18	automated	automate	VBN
cord-048466-fj9l8che	170	19	MagNA	MagNA	NNP
cord-048466-fj9l8che	170	20	Pure	Pure	NNP
cord-048466-fj9l8che	170	21	LC	LC	NNP
cord-048466-fj9l8che	170	22	Instrument	instrument	NN
cord-048466-fj9l8che	170	23	applying	apply	VBG
cord-048466-fj9l8che	170	24	the	the	DT
cord-048466-fj9l8che	170	25	MagNa	MagNa	NNP
cord-048466-fj9l8che	170	26	Pure	Pure	NNP
cord-048466-fj9l8che	170	27	LC	LC	NNP
cord-048466-fj9l8che	170	28	Total	total	NN
cord-048466-fj9l8che	170	29	Nucleic	Nucleic	NNP
cord-048466-fj9l8che	170	30	Acid	acid	NN
cord-048466-fj9l8che	170	31	Isolation	isolation	NN
cord-048466-fj9l8che	170	32	Kit	kit	NN
cord-048466-fj9l8che	170	33	(	(	-LRB-
cord-048466-fj9l8che	170	34	Roche	Roche	NNP
cord-048466-fj9l8che	170	35	Diagnostics	Diagnostics	NNP
cord-048466-fj9l8che	170	36	,	,	,
cord-048466-fj9l8che	170	37	Basel	Basel	NNP
cord-048466-fj9l8che	170	38	,	,	,
cord-048466-fj9l8che	170	39	Switzerland	Switzerland	NNP
cord-048466-fj9l8che	170	40	)	)	-RRB-
cord-048466-fj9l8che	170	41	.	.	.
cord-048466-fj9l8che	171	1	The	the	DT
cord-048466-fj9l8che	171	2	different	different	JJ
cord-048466-fj9l8che	171	3	gene	gene	NN
cord-048466-fj9l8che	171	4	segments	segment	NNS
cord-048466-fj9l8che	171	5	were	be	VBD
cord-048466-fj9l8che	171	6	amplified	amplify	VBN
cord-048466-fj9l8che	171	7	by	by	IN
cord-048466-fj9l8che	171	8	OneStep	OneStep	NNP
cord-048466-fj9l8che	171	9	RT	RT	NNP
cord-048466-fj9l8che	171	10	-	-	HYPH
cord-048466-fj9l8che	171	11	PCR	PCR	NNP
cord-048466-fj9l8che	171	12	Kit	kit	NN
cord-048466-fj9l8che	171	13	(	(	-LRB-
cord-048466-fj9l8che	171	14	QIAGEN	QIAGEN	NNP
cord-048466-fj9l8che	171	15	)	)	-RRB-
cord-048466-fj9l8che	171	16	as	as	IN
cord-048466-fj9l8che	171	17	previously	previously	RB
cord-048466-fj9l8che	171	18	described	describe	VBN
cord-048466-fj9l8che	171	19	[	[	-LRB-
cord-048466-fj9l8che	171	20	64	64	CD
cord-048466-fj9l8che	171	21	]	]	-RRB-
cord-048466-fj9l8che	171	22	,	,	,
cord-048466-fj9l8che	171	23	applying	apply	VBG
cord-048466-fj9l8che	171	24	a	a	DT
cord-048466-fj9l8che	171	25	two	two	CD
cord-048466-fj9l8che	171	26	minute	minute	NN
cord-048466-fj9l8che	171	27	elongation	elongation	NN
cord-048466-fj9l8che	171	28	step	step	NN
cord-048466-fj9l8che	171	29	for	for	IN
cord-048466-fj9l8che	171	30	all	all	DT
cord-048466-fj9l8che	171	31	genes	gene	NNS
cord-048466-fj9l8che	171	32	.	.	.
cord-048466-fj9l8che	172	1	The	the	DT
cord-048466-fj9l8che	172	2	primers	primer	NNS
cord-048466-fj9l8che	172	3	for	for	IN
cord-048466-fj9l8che	172	4	RT	RT	NNP
cord-048466-fj9l8che	172	5	-	-	HYPH
cord-048466-fj9l8che	172	6	PCR	PCR	NNP
cord-048466-fj9l8che	172	7	were	be	VBD
cord-048466-fj9l8che	172	8	segment	segment	NN
cord-048466-fj9l8che	172	9	specific	specific	JJ
cord-048466-fj9l8che	172	10	but	but	CC
cord-048466-fj9l8che	172	11	subtype	subtype	NN
cord-048466-fj9l8che	172	12	universal	universal	NN
cord-048466-fj9l8che	172	13	targeting	target	VBG
cord-048466-fj9l8che	172	14	the	the	DT
cord-048466-fj9l8che	172	15	highly	highly	RB
cord-048466-fj9l8che	172	16	conserved	conserved	JJ
cord-048466-fj9l8che	172	17	noncoding	noncoding	JJ
cord-048466-fj9l8che	172	18	RNA	RNA	NNP
cord-048466-fj9l8che	172	19	regions	region	NNS
cord-048466-fj9l8che	172	20	at	at	IN
cord-048466-fj9l8che	172	21	the	the	DT
cord-048466-fj9l8che	172	22	5'-and	5'-and	CD
cord-048466-fj9l8che	172	23	3'-end	3'-end	CD
cord-048466-fj9l8che	172	24	of	of	IN
cord-048466-fj9l8che	172	25	each	each	DT
cord-048466-fj9l8che	172	26	segment	segment	NN
cord-048466-fj9l8che	172	27	[	[	-LRB-
cord-048466-fj9l8che	172	28	65	65	CD
cord-048466-fj9l8che	172	29	]	]	-RRB-
cord-048466-fj9l8che	172	30	.	.	.
cord-048466-fj9l8che	173	1	PCR	PCR	NNP
cord-048466-fj9l8che	173	2	products	product	NNS
cord-048466-fj9l8che	173	3	were	be	VBD
cord-048466-fj9l8che	173	4	purified	purify	VBN
cord-048466-fj9l8che	173	5	using	use	VBG
cord-048466-fj9l8che	173	6	the	the	DT
cord-048466-fj9l8che	173	7	GFX	gfx	NN
cord-048466-fj9l8che	173	8	™	™	NN
cord-048466-fj9l8che	173	9	PCR	pcr	NN
cord-048466-fj9l8che	173	10	DNA	DNA	NNP
cord-048466-fj9l8che	173	11	and	and	CC
cord-048466-fj9l8che	173	12	Gel	Gel	NNP
cord-048466-fj9l8che	173	13	Band	Band	NNP
cord-048466-fj9l8che	173	14	Purification	Purification	NNP
cord-048466-fj9l8che	173	15	Kit	kit	NN
cord-048466-fj9l8che	173	16	(	(	-LRB-
cord-048466-fj9l8che	173	17	Amersham	Amersham	NNP
cord-048466-fj9l8che	173	18	Biosciences	Biosciences	NNP
cord-048466-fj9l8che	173	19	,	,	,
cord-048466-fj9l8che	173	20	Germany	Germany	NNP
cord-048466-fj9l8che	173	21	)	)	-RRB-
cord-048466-fj9l8che	173	22	prior	prior	RB
cord-048466-fj9l8che	173	23	to	to	IN
cord-048466-fj9l8che	173	24	sequencing	sequencing	NN
cord-048466-fj9l8che	173	25	.	.	.
cord-048466-fj9l8che	174	1	Purified	purify	VBN
cord-048466-fj9l8che	174	2	PCR	PCR	NNP
cord-048466-fj9l8che	174	3	products	product	NNS
cord-048466-fj9l8che	174	4	were	be	VBD
cord-048466-fj9l8che	174	5	sequenced	sequence	VBN
cord-048466-fj9l8che	174	6	directly	directly	RB
cord-048466-fj9l8che	174	7	.	.	.
cord-048466-fj9l8che	175	1	Primer	primer	NN
cord-048466-fj9l8che	175	2	sequences	sequence	NNS
cord-048466-fj9l8che	175	3	are	be	VBP
cord-048466-fj9l8che	175	4	available	available	JJ
cord-048466-fj9l8che	175	5	upon	upon	IN
cord-048466-fj9l8che	175	6	request	request	NN
cord-048466-fj9l8che	175	7	.	.	.
cord-048466-fj9l8che	176	1	The	the	DT
cord-048466-fj9l8che	176	2	sequencing	sequencing	NN
cord-048466-fj9l8che	176	3	reaction	reaction	NN
cord-048466-fj9l8che	176	4	was	be	VBD
cord-048466-fj9l8che	176	5	performed	perform	VBN
cord-048466-fj9l8che	176	6	by	by	IN
cord-048466-fj9l8che	176	7	ABI	ABI	NNP
cord-048466-fj9l8che	176	8	PRISM	PRISM	NNP
cord-048466-fj9l8che	177	1	®	®	,
cord-048466-fj9l8che	177	2	BigDye	BigDye	NNP
cord-048466-fj9l8che	177	3	™	™	NN
cord-048466-fj9l8che	177	4	Terminators	terminator	NNS
cord-048466-fj9l8che	177	5	v3.1	v3.1	NN
cord-048466-fj9l8che	177	6	Cycle	Cycle	NNP
cord-048466-fj9l8che	177	7	Sequencing	Sequencing	NNP
cord-048466-fj9l8che	177	8	Kit	kit	NN
cord-048466-fj9l8che	177	9	(	(	-LRB-
cord-048466-fj9l8che	177	10	Applied	Applied	NNP
cord-048466-fj9l8che	177	11	Biosystems	Biosystems	NNP
cord-048466-fj9l8che	177	12	,	,	,
cord-048466-fj9l8che	177	13	USA	USA	NNP
cord-048466-fj9l8che	177	14	)	)	-RRB-
cord-048466-fj9l8che	177	15	as	as	IN
cord-048466-fj9l8che	177	16	described	describe	VBN
cord-048466-fj9l8che	177	17	previously	previously	RB
cord-048466-fj9l8che	177	18	[	[	-LRB-
cord-048466-fj9l8che	177	19	66	66	CD
cord-048466-fj9l8che	177	20	]	]	-RRB-
cord-048466-fj9l8che	177	21	.	.	.
cord-048466-fj9l8che	178	1	The	the	DT
cord-048466-fj9l8che	178	2	sequences	sequence	NNS
cord-048466-fj9l8che	178	3	were	be	VBD
cord-048466-fj9l8che	178	4	developed	develop	VBN
cord-048466-fj9l8che	178	5	on	on	IN
cord-048466-fj9l8che	178	6	an	an	DT
cord-048466-fj9l8che	178	7	automatic	automatic	JJ
cord-048466-fj9l8che	178	8	ABI	ABI	NNP
cord-048466-fj9l8che	178	9	PRISM	PRISM	NNP
cord-048466-fj9l8che	178	10	®	®	POS
cord-048466-fj9l8che	178	11	3130	3130	CD
cord-048466-fj9l8che	178	12	genetic	genetic	JJ
cord-048466-fj9l8che	178	13	analyzer	analyzer	NN
cord-048466-fj9l8che	178	14	(	(	-LRB-
cord-048466-fj9l8che	178	15	Applied	Applied	NNP
cord-048466-fj9l8che	178	16	Biosystems	Biosystems	NNP
cord-048466-fj9l8che	178	17	)	)	-RRB-
cord-048466-fj9l8che	178	18	with	with	IN
cord-048466-fj9l8che	178	19	80	80	CD
cord-048466-fj9l8che	178	20	cm	cm	NN
cord-048466-fj9l8che	178	21	capillaries	capillary	NNS
cord-048466-fj9l8che	178	22	.	.	.
cord-048466-fj9l8che	179	1	Consensus	consensus	NN
cord-048466-fj9l8che	179	2	sequences	sequence	NNS
cord-048466-fj9l8che	179	3	were	be	VBD
cord-048466-fj9l8che	179	4	generated	generate	VBN
cord-048466-fj9l8che	179	5	in	in	IN
cord-048466-fj9l8che	179	6	SeqScape	SeqScape	NNP
cord-048466-fj9l8che	180	1	®	®	.
cord-048466-fj9l8che	180	2	Software	software	NN
cord-048466-fj9l8che	180	3	v2.5	v2.5	NN
cord-048466-fj9l8che	180	4	(	(	-LRB-
cord-048466-fj9l8che	180	5	Applied	Applied	NNP
cord-048466-fj9l8che	180	6	Biosystems	Biosystems	NNP
cord-048466-fj9l8che	180	7	)	)	-RRB-
cord-048466-fj9l8che	180	8	.	.	.
cord-048466-fj9l8che	181	1	Sequence	sequence	NN
cord-048466-fj9l8che	181	2	assembly	assembly	NN
cord-048466-fj9l8che	181	3	,	,	,
cord-048466-fj9l8che	181	4	multiple	multiple	JJ
cord-048466-fj9l8che	181	5	alignment	alignment	NN
cord-048466-fj9l8che	181	6	and	and	CC
cord-048466-fj9l8che	181	7	alignment	alignment	NN
cord-048466-fj9l8che	181	8	trimming	trimming	NN
cord-048466-fj9l8che	181	9	were	be	VBD
cord-048466-fj9l8che	181	10	performed	perform	VBN
cord-048466-fj9l8che	181	11	with	with	IN
cord-048466-fj9l8che	181	12	the	the	DT
cord-048466-fj9l8che	181	13	BioEdit	BioEdit	NNP
cord-048466-fj9l8che	181	14	software	software	NN
cord-048466-fj9l8che	182	1	v.7.0.5	v.7.0.5	NNP
cord-048466-fj9l8che	182	2	[	[	-LRB-
cord-048466-fj9l8che	182	3	67	67	CD
cord-048466-fj9l8che	182	4	]	]	-RRB-
cord-048466-fj9l8che	182	5	.	.	.
cord-048466-fj9l8che	183	1	Distance	distance	NN
cord-048466-fj9l8che	183	2	based	base	VBN
cord-048466-fj9l8che	183	3	neighbor	neighbor	NN
cord-048466-fj9l8che	183	4	joining	join	VBG
cord-048466-fj9l8che	183	5	(	(	-LRB-
cord-048466-fj9l8che	183	6	NJ	NJ	NNP
cord-048466-fj9l8che	183	7	)	)	-RRB-
cord-048466-fj9l8che	183	8	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	183	9	trees	tree	NNS
cord-048466-fj9l8che	183	10	and	and	CC
cord-048466-fj9l8che	183	11	character	character	NN
cord-048466-fj9l8che	184	1	based	base	VBN
cord-048466-fj9l8che	184	2	maximum	maximum	JJ
cord-048466-fj9l8che	184	3	parsimony	parsimony	NN
cord-048466-fj9l8che	184	4	(	(	-LRB-
cord-048466-fj9l8che	184	5	MP	MP	NNP
cord-048466-fj9l8che	184	6	)	)	-RRB-
cord-048466-fj9l8che	184	7	trees	tree	NNS
cord-048466-fj9l8che	184	8	were	be	VBD
cord-048466-fj9l8che	184	9	generated	generate	VBN
cord-048466-fj9l8che	184	10	using	use	VBG
cord-048466-fj9l8che	184	11	the	the	DT
cord-048466-fj9l8che	184	12	Molecular	Molecular	NNP
cord-048466-fj9l8che	184	13	Evolutionary	Evolutionary	NNP
cord-048466-fj9l8che	184	14	Genetics	Genetics	NNP
cord-048466-fj9l8che	184	15	Analysis	Analysis	NNP
cord-048466-fj9l8che	184	16	(	(	-LRB-
cord-048466-fj9l8che	184	17	MEGA	MEGA	NNP
cord-048466-fj9l8che	184	18	)	)	-RRB-
cord-048466-fj9l8che	184	19	software	software	NN
cord-048466-fj9l8che	184	20	v.3.1	v.3.1	.
cord-048466-fj9l8che	184	21	[	[	-LRB-
cord-048466-fj9l8che	184	22	68	68	CD
cord-048466-fj9l8che	184	23	]	]	-RRB-
cord-048466-fj9l8che	184	24	.	.	.
cord-048466-fj9l8che	185	1	Maximum	maximum	JJ
cord-048466-fj9l8che	185	2	likelihood	likelihood	NN
cord-048466-fj9l8che	185	3	trees	tree	NNS
cord-048466-fj9l8che	185	4	were	be	VBD
cord-048466-fj9l8che	185	5	generated	generate	VBN
cord-048466-fj9l8che	185	6	by	by	IN
cord-048466-fj9l8che	185	7	the	the	DT
cord-048466-fj9l8che	185	8	Phylogenetic	Phylogenetic	NNP
cord-048466-fj9l8che	185	9	Analysis	Analysis	NNP
cord-048466-fj9l8che	185	10	Using	use	VBG
cord-048466-fj9l8che	185	11	Parsimony	Parsimony	NNP
cord-048466-fj9l8che	185	12	(	(	-LRB-
cord-048466-fj9l8che	185	13	PAUP	PAUP	NNP
cord-048466-fj9l8che	185	14	4.0	4.0	CD
cord-048466-fj9l8che	185	15	)	)	-RRB-
cord-048466-fj9l8che	185	16	Software	software	NN
cord-048466-fj9l8che	185	17	(	(	-LRB-
cord-048466-fj9l8che	185	18	Sinauer	Sinauer	NNP
cord-048466-fj9l8che	185	19	Associates	Associates	NNPS
cord-048466-fj9l8che	185	20	,	,	,
cord-048466-fj9l8che	185	21	Inc.	Inc.	NNP
cord-048466-fj9l8che	185	22	)	)	-RRB-
cord-048466-fj9l8che	185	23	[	[	-LRB-
cord-048466-fj9l8che	185	24	69	69	CD
cord-048466-fj9l8che	185	25	]	]	-RRB-
cord-048466-fj9l8che	185	26	applying	apply	VBG
cord-048466-fj9l8che	185	27	the	the	DT
cord-048466-fj9l8che	185	28	HKY85	HKY85	NNP
cord-048466-fj9l8che	185	29	nucleotide	nucleotide	JJ
cord-048466-fj9l8che	185	30	model	model	NN
cord-048466-fj9l8che	185	31	,	,	,
cord-048466-fj9l8che	185	32	allowing	allow	VBG
cord-048466-fj9l8che	185	33	transitions	transition	NNS
cord-048466-fj9l8che	185	34	and	and	CC
cord-048466-fj9l8che	185	35	transversions	transversion	NNS
cord-048466-fj9l8che	185	36	to	to	TO
cord-048466-fj9l8che	185	37	occur	occur	VB
cord-048466-fj9l8che	185	38	at	at	IN
cord-048466-fj9l8che	185	39	different	different	JJ
cord-048466-fj9l8che	185	40	rates	rate	NNS
cord-048466-fj9l8che	185	41	.	.	.
cord-048466-fj9l8che	186	1	The	the	DT
cord-048466-fj9l8che	186	2	between	between	IN
cord-048466-fj9l8che	186	3	-	-	HYPH
cord-048466-fj9l8che	186	4	seasons	season	NNS
cord-048466-fj9l8che	186	5	nucleotide	nucleotide	JJ
cord-048466-fj9l8che	186	6	distance	distance	NN
cord-048466-fj9l8che	186	7	means	mean	NNS
cord-048466-fj9l8che	186	8	were	be	VBD
cord-048466-fj9l8che	186	9	computed	compute	VBN
cord-048466-fj9l8che	186	10	as	as	IN
cord-048466-fj9l8che	186	11	the	the	DT
cord-048466-fj9l8che	186	12	arithmetic	arithmetic	JJ
cord-048466-fj9l8che	186	13	mean	mean	NN
cord-048466-fj9l8che	186	14	of	of	IN
cord-048466-fj9l8che	186	15	all	all	DT
cord-048466-fj9l8che	186	16	pair	pair	VBP
cord-048466-fj9l8che	186	17	wise	wise	JJ
cord-048466-fj9l8che	186	18	distances	distance	NNS
cord-048466-fj9l8che	186	19	between	between	IN
cord-048466-fj9l8che	186	20	two	two	CD
cord-048466-fj9l8che	186	21	seasons	season	NNS
cord-048466-fj9l8che	186	22	in	in	IN
cord-048466-fj9l8che	186	23	the	the	DT
cord-048466-fj9l8che	186	24	inter	inter	JJ
cord-048466-fj9l8che	186	25	-	-	JJ
cord-048466-fj9l8che	186	26	season	season	JJ
cord-048466-fj9l8che	186	27	comparisons	comparison	NNS
cord-048466-fj9l8che	186	28	using	use	VBG
cord-048466-fj9l8che	186	29	the	the	DT
cord-048466-fj9l8che	186	30	MEGA	mega	JJ
cord-048466-fj9l8che	186	31	v.3.1	v.3.1	NN
cord-048466-fj9l8che	186	32	software	software	NN
cord-048466-fj9l8che	186	33	[	[	-LRB-
cord-048466-fj9l8che	186	34	68	68	CD
cord-048466-fj9l8che	186	35	]	]	-RRB-
cord-048466-fj9l8che	186	36	.	.	.
cord-048466-fj9l8che	187	1	The	the	DT
cord-048466-fj9l8che	187	2	global	global	JJ
cord-048466-fj9l8che	187	3	rate	rate	NN
cord-048466-fj9l8che	187	4	between	between	IN
cord-048466-fj9l8che	187	5	dN	dN	NNP
cord-048466-fj9l8che	187	6	and	and	CC
cord-048466-fj9l8che	187	7	dS	dS	NNP
cord-048466-fj9l8che	187	8	substitutions	substitution	NNS
cord-048466-fj9l8che	187	9	and	and	CC
cord-048466-fj9l8che	187	10	the	the	DT
cord-048466-fj9l8che	187	11	individual	individual	JJ
cord-048466-fj9l8che	187	12	sitespecific	sitespecific	NN
cord-048466-fj9l8che	187	13	selection	selection	NN
cord-048466-fj9l8che	187	14	pressure	pressure	NN
cord-048466-fj9l8che	187	15	were	be	VBD
cord-048466-fj9l8che	187	16	measured	measure	VBN
cord-048466-fj9l8che	187	17	by	by	IN
cord-048466-fj9l8che	187	18	the	the	DT
cord-048466-fj9l8che	187	19	likelihood	likelihood	NN
cord-048466-fj9l8che	187	20	based	base	VBN
cord-048466-fj9l8che	187	21	single	single	JJ
cord-048466-fj9l8che	187	22	likelihood	likelihood	NN
cord-048466-fj9l8che	187	23	ancestor	ancestor	NN
cord-048466-fj9l8che	187	24	counting	count	VBG
cord-048466-fj9l8che	187	25	(	(	-LRB-
cord-048466-fj9l8che	187	26	SLAC	SLAC	NNP
cord-048466-fj9l8che	187	27	)	)	-RRB-
cord-048466-fj9l8che	187	28	method	method	NN
cord-048466-fj9l8che	187	29	in	in	IN
cord-048466-fj9l8che	187	30	Datamonkey	Datamonkey	NNP
cord-048466-fj9l8che	187	31	(	(	-LRB-
cord-048466-fj9l8che	187	32	modified	modify	VBN
cord-048466-fj9l8che	187	33	Suzuki	Suzuki	NNP
cord-048466-fj9l8che	187	34	-	-	HYPH
cord-048466-fj9l8che	187	35	Gojobori	Gojobori	NNP
cord-048466-fj9l8che	187	36	method	method	NN
cord-048466-fj9l8che	187	37	)	)	-RRB-
cord-048466-fj9l8che	187	38	[	[	-LRB-
cord-048466-fj9l8che	187	39	70	70	CD
cord-048466-fj9l8che	187	40	,	,	,
cord-048466-fj9l8che	187	41	71	71	CD
cord-048466-fj9l8che	187	42	]	]	-RRB-
cord-048466-fj9l8che	187	43	.	.	.
cord-048466-fj9l8che	188	1	For	for	IN
cord-048466-fj9l8che	188	2	datasets	dataset	NNS
cord-048466-fj9l8che	188	3	over	over	IN
cord-048466-fj9l8che	188	4	100	100	CD
cord-048466-fj9l8che	188	5	sequences	sequence	NNS
cord-048466-fj9l8che	188	6	(	(	-LRB-
cord-048466-fj9l8che	188	7	H3	H3	NNP
cord-048466-fj9l8che	188	8	n	n	CC
cord-048466-fj9l8che	188	9	=	=	SYM
cord-048466-fj9l8che	188	10	204	204	CD
cord-048466-fj9l8che	188	11	and	and	CC
cord-048466-fj9l8che	188	12	N2	n2	NN
cord-048466-fj9l8che	188	13	n	n	NN
cord-048466-fj9l8che	188	14	=	=	SYM
cord-048466-fj9l8che	188	15	166	166	CD
cord-048466-fj9l8che	188	16	)	)	-RRB-
cord-048466-fj9l8che	188	17	the	the	DT
cord-048466-fj9l8che	188	18	HyPhy	HyPhy	NNP
cord-048466-fj9l8che	188	19	package	package	NN
cord-048466-fj9l8che	188	20	[	[	-LRB-
cord-048466-fj9l8che	188	21	72	72	CD
cord-048466-fj9l8che	188	22	]	]	-RRB-
cord-048466-fj9l8che	188	23	was	be	VBD
cord-048466-fj9l8che	188	24	applied	apply	VBN
cord-048466-fj9l8che	188	25	.	.	.
cord-048466-fj9l8che	189	1	The	the	DT
cord-048466-fj9l8che	189	2	estimations	estimation	NNS
cord-048466-fj9l8che	189	3	are	be	VBP
cord-048466-fj9l8che	189	4	likelihood	likelihood	NN
cord-048466-fj9l8che	189	5	-	-	HYPH
cord-048466-fj9l8che	189	6	based	base	VBN
cord-048466-fj9l8che	189	7	,	,	,
cord-048466-fj9l8che	189	8	employing	employ	VBG
cord-048466-fj9l8che	189	9	a	a	DT
cord-048466-fj9l8che	189	10	codon	codon	NN
cord-048466-fj9l8che	189	11	model	model	NN
cord-048466-fj9l8che	189	12	cross	cross	NN
cord-048466-fj9l8che	189	13	between	between	IN
cord-048466-fj9l8che	189	14	HKY85	HKY85	NNP
cord-048466-fj9l8che	189	15	and	and	CC
cord-048466-fj9l8che	189	16	MG94	MG94	NNP
cord-048466-fj9l8che	189	17	.	.	.
cord-048466-fj9l8che	190	1	To	to	TO
cord-048466-fj9l8che	190	2	elucidate	elucidate	VB
cord-048466-fj9l8che	190	3	single	single	JJ
cord-048466-fj9l8che	190	4	,	,	,
cord-048466-fj9l8che	190	5	positively	positively	RB
cord-048466-fj9l8che	190	6	selected	select	VBN
cord-048466-fj9l8che	190	7	amino	amino	JJ
cord-048466-fj9l8che	190	8	acids	acid	NNS
cord-048466-fj9l8che	190	9	,	,	,
cord-048466-fj9l8che	190	10	the	the	DT
cord-048466-fj9l8che	190	11	HA	HA	NNP
cord-048466-fj9l8che	190	12	and	and	CC
cord-048466-fj9l8che	190	13	NA	NA	NNP
cord-048466-fj9l8che	190	14	datasets	dataset	NNS
cord-048466-fj9l8che	190	15	were	be	VBD
cord-048466-fj9l8che	190	16	analysed	analyse	VBN
cord-048466-fj9l8che	190	17	with	with	IN
cord-048466-fj9l8che	190	18	SLAC	SLAC	NNP
cord-048466-fj9l8che	190	19	and	and	CC
cord-048466-fj9l8che	190	20	a	a	DT
cord-048466-fj9l8che	190	21	two	two	CD
cord-048466-fj9l8che	190	22	rate	rate	NN
cord-048466-fj9l8che	190	23	fixed	fix	VBN
cord-048466-fj9l8che	190	24	effects	effect	NNS
cord-048466-fj9l8che	190	25	likelihood	likelihood	NN
cord-048466-fj9l8che	190	26	(	(	-LRB-
cord-048466-fj9l8che	190	27	FEL	FEL	NNP
cord-048466-fj9l8che	190	28	)	)	-RRB-
cord-048466-fj9l8che	190	29	[	[	-LRB-
cord-048466-fj9l8che	190	30	73	73	CD
cord-048466-fj9l8che	190	31	]	]	-RRB-
cord-048466-fj9l8che	190	32	using	use	VBG
cord-048466-fj9l8che	190	33	a	a	DT
cord-048466-fj9l8che	190	34	likelihood	likelihood	NN
cord-048466-fj9l8che	190	35	approach	approach	NN
cord-048466-fj9l8che	190	36	with	with	IN
cord-048466-fj9l8che	190	37	neighbor	neighbor	NN
cord-048466-fj9l8che	190	38	joining	join	VBG
cord-048466-fj9l8che	190	39	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	190	40	trees	tree	NNS
cord-048466-fj9l8che	190	41	(	(	-LRB-
cord-048466-fj9l8che	190	42	HyPhy	HyPhy	NNP
cord-048466-fj9l8che	190	43	)	)	-RRB-
cord-048466-fj9l8che	190	44	.	.	.
cord-048466-fj9l8che	191	1	Sites	site	NNS
cord-048466-fj9l8che	191	2	with	with	IN
cord-048466-fj9l8che	191	3	dN	dN	NNP
cord-048466-fj9l8che	192	1	>	>	XX
cord-048466-fj9l8che	193	1	dS	dS	NNP
cord-048466-fj9l8che	193	2	with	with	IN
cord-048466-fj9l8che	193	3	a	a	DT
cord-048466-fj9l8che	193	4	<	<	XX
cord-048466-fj9l8che	193	5	0.05	0.05	CD
cord-048466-fj9l8che	193	6	significance	significance	NN
cord-048466-fj9l8che	193	7	level	level	NN
cord-048466-fj9l8che	193	8	for	for	IN
cord-048466-fj9l8che	193	9	likelihood	likelihood	NN
cord-048466-fj9l8che	193	10	ratio	ratio	NN
cord-048466-fj9l8che	193	11	test	test	NN
cord-048466-fj9l8che	193	12	(	(	-LRB-
cord-048466-fj9l8che	193	13	LRT	LRT	NNP
cord-048466-fj9l8che	193	14	)	)	-RRB-
cord-048466-fj9l8che	193	15	were	be	VBD
cord-048466-fj9l8che	193	16	implied	imply	VBN
cord-048466-fj9l8che	193	17	as	as	IN
cord-048466-fj9l8che	193	18	positively	positively	RB
cord-048466-fj9l8che	193	19	selected	select	VBN
cord-048466-fj9l8che	193	20	for	for	IN
cord-048466-fj9l8che	193	21	the	the	DT
cord-048466-fj9l8che	193	22	large	large	JJ
cord-048466-fj9l8che	193	23	HA	HA	NNP
cord-048466-fj9l8che	193	24	and	and	CC
cord-048466-fj9l8che	193	25	NA	NA	NNP
cord-048466-fj9l8che	193	26	datasets	dataset	NNS
cord-048466-fj9l8che	193	27	.	.	.
cord-048466-fj9l8che	194	1	For	for	IN
cord-048466-fj9l8che	194	2	the	the	DT
cord-048466-fj9l8che	194	3	small	small	JJ
cord-048466-fj9l8che	194	4	datasets	dataset	NNS
cord-048466-fj9l8che	194	5	(	(	-LRB-
cord-048466-fj9l8che	194	6	genes	gene	NNS
cord-048466-fj9l8che	194	7	coding	code	VBG
cord-048466-fj9l8che	194	8	for	for	IN
cord-048466-fj9l8che	194	9	the	the	DT
cord-048466-fj9l8che	194	10	internal	internal	JJ
cord-048466-fj9l8che	194	11	proteins	protein	NNS
cord-048466-fj9l8che	194	12	<	<	XX
cord-048466-fj9l8che	194	13	15	15	CD
cord-048466-fj9l8che	194	14	and	and	CC
cord-048466-fj9l8che	194	15	the	the	DT
cord-048466-fj9l8che	194	16	H1N1	H1N1	NNP
cord-048466-fj9l8che	194	17	viruses	virus	NNS
cord-048466-fj9l8che	194	18	<	<	XX
cord-048466-fj9l8che	194	19	30	30	CD
cord-048466-fj9l8che	194	20	)	)	-RRB-
cord-048466-fj9l8che	194	21	we	-PRON-	PRP
cord-048466-fj9l8che	194	22	additionally	additionally	RB
cord-048466-fj9l8che	194	23	ran	run	VBD
cord-048466-fj9l8che	194	24	a	a	DT
cord-048466-fj9l8che	194	25	random	random	JJ
cord-048466-fj9l8che	194	26	effects	effect	NNS
cord-048466-fj9l8che	194	27	likelihood	likelihood	NN
cord-048466-fj9l8che	194	28	(	(	-LRB-
cord-048466-fj9l8che	194	29	REL	REL	NNP
cord-048466-fj9l8che	194	30	)	)	-RRB-
cord-048466-fj9l8che	194	31	analysis	analysis	NN
cord-048466-fj9l8che	194	32	using	use	VBG
cord-048466-fj9l8che	194	33	an	an	DT
cord-048466-fj9l8che	194	34	empirical	empirical	JJ
cord-048466-fj9l8che	194	35	Bayes	Bayes	NNP
cord-048466-fj9l8che	194	36	approach	approach	NN
cord-048466-fj9l8che	194	37	with	with	IN
cord-048466-fj9l8che	194	38	NJ	NJ	NNP
cord-048466-fj9l8che	194	39	phylogenetic	phylogenetic	JJ
cord-048466-fj9l8che	194	40	trees	tree	NNS
cord-048466-fj9l8che	194	41	in	in	IN
cord-048466-fj9l8che	194	42	Datamonkey	Datamonkey	NNP
cord-048466-fj9l8che	194	43	[	[	-LRB-
cord-048466-fj9l8che	194	44	70	70	CD
cord-048466-fj9l8che	194	45	]	]	-RRB-
cord-048466-fj9l8che	194	46	.	.	.
cord-048466-fj9l8che	195	1	This	this	DT
cord-048466-fj9l8che	195	2	method	method	NN
cord-048466-fj9l8che	195	3	is	be	VBZ
cord-048466-fj9l8che	195	4	expected	expect	VBN
cord-048466-fj9l8che	195	5	to	to	TO
cord-048466-fj9l8che	195	6	calculate	calculate	VB
cord-048466-fj9l8che	195	7	positively	positively	RB
cord-048466-fj9l8che	195	8	selected	select	VBN
cord-048466-fj9l8che	195	9	sites	site	NNS
cord-048466-fj9l8che	195	10	more	more	RBR
cord-048466-fj9l8che	195	11	accurately	accurately	RB
cord-048466-fj9l8che	195	12	in	in	IN
cord-048466-fj9l8che	195	13	small	small	JJ
cord-048466-fj9l8che	195	14	datasets	dataset	NNS
cord-048466-fj9l8che	195	15	.	.	.
cord-048466-fj9l8che	196	1	The	the	DT
cord-048466-fj9l8che	196	2	accepted	accepted	JJ
cord-048466-fj9l8che	196	3	significance	significance	NN
cord-048466-fj9l8che	196	4	level	level	NN
cord-048466-fj9l8che	196	5	for	for	IN
cord-048466-fj9l8che	196	6	a	a	DT
cord-048466-fj9l8che	196	7	positively	positively	RB
cord-048466-fj9l8che	196	8	selected	select	VBN
cord-048466-fj9l8che	196	9	site	site	NN
cord-048466-fj9l8che	196	10	was	be	VBD
cord-048466-fj9l8che	196	11	set	set	VBN
cord-048466-fj9l8che	196	12	at	at	IN
cord-048466-fj9l8che	196	13	<	<	XX
cord-048466-fj9l8che	196	14	0.1	0.1	CD
cord-048466-fj9l8che	196	15	(	(	-LRB-
cord-048466-fj9l8che	196	16	two	two	CD
cord-048466-fj9l8che	196	17	-	-	HYPH
cord-048466-fj9l8che	196	18	tailed	tailed	JJ
cord-048466-fj9l8che	196	19	binominal	binominal	NN
cord-048466-fj9l8che	196	20	distribution	distribution	NN
cord-048466-fj9l8che	196	21	)	)	-RRB-
cord-048466-fj9l8che	196	22	for	for	IN
cord-048466-fj9l8che	196	23	SLAC	SLAC	NNP
cord-048466-fj9l8che	196	24	and	and	CC
cord-048466-fj9l8che	196	25	FEL	FEL	NNP
cord-048466-fj9l8che	196	26	analyses	analysis	NNS
cord-048466-fj9l8che	196	27	and	and	CC
cord-048466-fj9l8che	196	28	>	>	XX
cord-048466-fj9l8che	196	29	50	50	CD
cord-048466-fj9l8che	196	30	bayes	bayes	NN
cord-048466-fj9l8che	196	31	factor	factor	NN
cord-048466-fj9l8che	196	32	for	for	IN
cord-048466-fj9l8che	196	33	REL	REL	NNP
cord-048466-fj9l8che	196	34	.	.	.
cord-048466-fj9l8che	197	1	Potential	potential	JJ
cord-048466-fj9l8che	197	2	N	n	CD
cord-048466-fj9l8che	197	3	-	-	HYPH
cord-048466-fj9l8che	197	4	linked	link	VBN
cord-048466-fj9l8che	197	5	glycosylation	glycosylation	NN
cord-048466-fj9l8che	197	6	sites	site	NNS
cord-048466-fj9l8che	197	7	were	be	VBD
cord-048466-fj9l8che	197	8	predicted	predict	VBN
cord-048466-fj9l8che	197	9	using	use	VBG
cord-048466-fj9l8che	197	10	nine	nine	CD
cord-048466-fj9l8che	197	11	artificial	artificial	JJ
cord-048466-fj9l8che	197	12	neural	neural	JJ
cord-048466-fj9l8che	197	13	networks	network	NNS
cord-048466-fj9l8che	197	14	with	with	IN
cord-048466-fj9l8che	197	15	the	the	DT
cord-048466-fj9l8che	197	16	NetNGlyc	NetNGlyc	NNP
cord-048466-fj9l8che	197	17	1.0	1.0	CD
cord-048466-fj9l8che	197	18	Server	server	NN
cord-048466-fj9l8che	197	19	[	[	-LRB-
cord-048466-fj9l8che	197	20	74	74	CD
cord-048466-fj9l8che	197	21	]	]	-RRB-
cord-048466-fj9l8che	197	22	.	.	.
cord-048466-fj9l8che	198	1	A	a	DT
cord-048466-fj9l8che	198	2	threshold	threshold	NN
cord-048466-fj9l8che	198	3	value	value	NN
cord-048466-fj9l8che	198	4	of	of	IN
cord-048466-fj9l8che	198	5	>	>	$
cord-048466-fj9l8che	198	6	0.5	0.5	CD
cord-048466-fj9l8che	198	7	average	average	JJ
cord-048466-fj9l8che	198	8	potential	potential	JJ
cord-048466-fj9l8che	198	9	score	score	NN
cord-048466-fj9l8che	198	10	was	be	VBD
cord-048466-fj9l8che	198	11	set	set	VBN
cord-048466-fj9l8che	198	12	to	to	TO
cord-048466-fj9l8che	198	13	predict	predict	VB
cord-048466-fj9l8che	198	14	glycosylated	glycosylated	JJ
cord-048466-fj9l8che	198	15	sites	site	NNS
cord-048466-fj9l8che	198	16	.	.	.
cord-048466-fj9l8che	199	1	The	the	DT
cord-048466-fj9l8che	199	2	N	N	NNP
cord-048466-fj9l8che	199	3	-	-	HYPH
cord-048466-fj9l8che	199	4	Glycosite	Glycosite	NNP
cord-048466-fj9l8che	199	5	prediction	prediction	NN
cord-048466-fj9l8che	199	6	tool	tool	NN
cord-048466-fj9l8che	199	7	at	at	IN
cord-048466-fj9l8che	199	8	Los	Los	NNP
cord-048466-fj9l8che	199	9	Alamos	Alamos	NNP
cord-048466-fj9l8che	199	10	[	[	-LRB-
cord-048466-fj9l8che	199	11	75	75	CD
cord-048466-fj9l8che	199	12	]	]	-RRB-
cord-048466-fj9l8che	199	13	was	be	VBD
cord-048466-fj9l8che	199	14	used	use	VBN
cord-048466-fj9l8che	199	15	to	to	TO
cord-048466-fj9l8che	199	16	visualise	visualise	VB
cord-048466-fj9l8che	199	17	the	the	DT
cord-048466-fj9l8che	199	18	fraction	fraction	NN
cord-048466-fj9l8che	199	19	of	of	IN
cord-048466-fj9l8che	199	20	isolates	isolate	NNS
cord-048466-fj9l8che	199	21	possessing	possess	VBG
cord-048466-fj9l8che	199	22	certain	certain	JJ
cord-048466-fj9l8che	199	23	glycosylated	glycosylated	JJ
cord-048466-fj9l8che	199	24	sites	site	NNS
cord-048466-fj9l8che	199	25	along	along	IN
cord-048466-fj9l8che	199	26	the	the	DT
cord-048466-fj9l8che	199	27	sequence	sequence	NN
cord-048466-fj9l8che	199	28	alignment	alignment	NN
cord-048466-fj9l8che	199	29	.	.	.
cord-048466-fj9l8che	200	1	The	the	DT
cord-048466-fj9l8che	200	2	specific	specific	JJ
cord-048466-fj9l8che	200	3	measure	measure	NN
cord-048466-fj9l8che	200	4	of	of	IN
cord-048466-fj9l8che	200	5	antigenic	antigenic	JJ
cord-048466-fj9l8che	200	6	distance	distance	NN
cord-048466-fj9l8che	200	7	between	between	IN
cord-048466-fj9l8che	200	8	two	two	CD
cord-048466-fj9l8che	200	9	strains	strain	NNS
cord-048466-fj9l8che	200	10	of	of	IN
cord-048466-fj9l8che	200	11	influenza	influenza	NN
cord-048466-fj9l8che	200	12	were	be	VBD
cord-048466-fj9l8che	200	13	calculated	calculate	VBN
cord-048466-fj9l8che	200	14	as	as	IN
cord-048466-fj9l8che	200	15	P	p	NN
cord-048466-fj9l8che	200	16	epitope	epitope	NN
cord-048466-fj9l8che	200	17	values	value	NNS
cord-048466-fj9l8che	200	18	by	by	IN
cord-048466-fj9l8che	200	19	the	the	DT
cord-048466-fj9l8che	200	20	method	method	NN
cord-048466-fj9l8che	200	21	suggested	suggest	VBN
cord-048466-fj9l8che	200	22	by	by	IN
cord-048466-fj9l8che	200	23	Muñoz	Muñoz	NNP
cord-048466-fj9l8che	200	24	,	,	,
cord-048466-fj9l8che	200	25	et	et	NNP
cord-048466-fj9l8che	200	26	al	al	NNP
cord-048466-fj9l8che	200	27	.	.	NNP
cord-048466-fj9l8che	200	28	,	,	,
cord-048466-fj9l8che	200	29	[	[	-LRB-
cord-048466-fj9l8che	200	30	39	39	CD
cord-048466-fj9l8che	200	31	]	]	-RRB-
cord-048466-fj9l8che	200	32	.	.	.
cord-048466-fj9l8che	201	1	The	the	DT
cord-048466-fj9l8che	201	2	P	p	NN
cord-048466-fj9l8che	201	3	epitope	epitope	NN
cord-048466-fj9l8che	201	4	value	value	NN
cord-048466-fj9l8che	201	5	was	be	VBD
cord-048466-fj9l8che	201	6	calculated	calculate	VBN
cord-048466-fj9l8che	201	7	as	as	IN
cord-048466-fj9l8che	201	8	the	the	DT
cord-048466-fj9l8che	201	9	number	number	NN
cord-048466-fj9l8che	201	10	of	of	IN
cord-048466-fj9l8che	201	11	mutations	mutation	NNS
cord-048466-fj9l8che	201	12	within	within	IN
cord-048466-fj9l8che	201	13	an	an	DT
cord-048466-fj9l8che	201	14	antibody	antibody	NN
cord-048466-fj9l8che	201	15	antigenic	antigenic	JJ
cord-048466-fj9l8che	201	16	site	site	NN
cord-048466-fj9l8che	201	17	divided	divide	VBN
cord-048466-fj9l8che	201	18	by	by	IN
cord-048466-fj9l8che	201	19	the	the	DT
cord-048466-fj9l8che	201	20	number	number	NN
cord-048466-fj9l8che	201	21	of	of	IN
cord-048466-fj9l8che	201	22	amino	amino	JJ
cord-048466-fj9l8che	201	23	acids	acid	NNS
cord-048466-fj9l8che	201	24	defining	define	VBG
cord-048466-fj9l8che	201	25	the	the	DT
cord-048466-fj9l8che	201	26	site	site	NN
cord-048466-fj9l8che	201	27	.	.	.
cord-048466-fj9l8che	202	1	It	-PRON-	PRP
cord-048466-fj9l8che	202	2	is	be	VBZ
cord-048466-fj9l8che	202	3	assumed	assume	VBN
cord-048466-fj9l8che	202	4	that	that	IN
cord-048466-fj9l8che	202	5	an	an	DT
cord-048466-fj9l8che	202	6	antigenic	antigenic	JJ
cord-048466-fj9l8che	202	7	epitope	epitope	NN
cord-048466-fj9l8che	202	8	which	which	WDT
cord-048466-fj9l8che	202	9	has	have	VBZ
cord-048466-fj9l8che	202	10	the	the	DT
cord-048466-fj9l8che	202	11	greatest	great	JJS
cord-048466-fj9l8che	202	12	percentage	percentage	NN
cord-048466-fj9l8che	202	13	of	of	IN
cord-048466-fj9l8che	202	14	mutations	mutation	NNS
cord-048466-fj9l8che	202	15	is	be	VBZ
cord-048466-fj9l8che	202	16	dominant	dominant	JJ
cord-048466-fj9l8che	202	17	,	,	,
cord-048466-fj9l8che	202	18	because	because	IN
cord-048466-fj9l8che	202	19	that	that	DT
cord-048466-fj9l8che	202	20	epitope	epitope	NN
cord-048466-fj9l8che	202	21	is	be	VBZ
cord-048466-fj9l8che	202	22	influenced	influence	VBN
cord-048466-fj9l8che	202	23	by	by	IN
cord-048466-fj9l8che	202	24	the	the	DT
cord-048466-fj9l8che	202	25	greatest	great	JJS
cord-048466-fj9l8che	202	26	selective	selective	JJ
cord-048466-fj9l8che	202	27	pressure	pressure	NN
cord-048466-fj9l8che	202	28	from	from	IN
cord-048466-fj9l8che	202	29	the	the	DT
cord-048466-fj9l8che	202	30	immune	immune	JJ
cord-048466-fj9l8che	202	31	system	system	NN
cord-048466-fj9l8che	202	32	.	.	.
cord-048466-fj9l8che	203	1	The	the	DT
cord-048466-fj9l8che	203	2	P	p	NN
cord-048466-fj9l8che	203	3	epitope	epitope	NN
cord-048466-fj9l8che	203	4	distance	distance	NN
cord-048466-fj9l8che	203	5	is	be	VBZ
cord-048466-fj9l8che	203	6	defined	define	VBN
cord-048466-fj9l8che	203	7	as	as	IN
cord-048466-fj9l8che	203	8	the	the	DT
cord-048466-fj9l8che	203	9	fractional	fractional	JJ
cord-048466-fj9l8che	203	10	change	change	NN
cord-048466-fj9l8che	203	11	between	between	IN
cord-048466-fj9l8che	203	12	the	the	DT
cord-048466-fj9l8che	203	13	dominant	dominant	JJ
cord-048466-fj9l8che	203	14	antigenic	antigenic	JJ
cord-048466-fj9l8che	203	15	epitopes	epitope	NNS
cord-048466-fj9l8che	203	16	of	of	IN
cord-048466-fj9l8che	203	17	one	one	CD
cord-048466-fj9l8che	203	18	strain	strain	NN
cord-048466-fj9l8che	203	19	compared	compare	VBN
cord-048466-fj9l8che	203	20	to	to	IN
cord-048466-fj9l8che	203	21	another	another	DT
cord-048466-fj9l8che	203	22	.	.	.
cord-048466-fj9l8che	204	1	The	the	DT
cord-048466-fj9l8che	204	2	P	p	NN
cord-048466-fj9l8che	204	3	epitope	epitope	NN
cord-048466-fj9l8che	204	4	Calculator	calculator	NN
cord-048466-fj9l8che	204	5	[	[	-LRB-
cord-048466-fj9l8che	204	6	76	76	CD
cord-048466-fj9l8che	204	7	,	,	,
cord-048466-fj9l8che	204	8	77	77	CD
cord-048466-fj9l8che	204	9	]	]	-RRB-
cord-048466-fj9l8che	204	10	was	be	VBD
cord-048466-fj9l8che	204	11	applied	apply	VBN
cord-048466-fj9l8che	204	12	for	for	IN
cord-048466-fj9l8che	204	13	H3	H3	NNP
cord-048466-fj9l8che	204	14	sequences	sequence	NNS
cord-048466-fj9l8che	204	15	.	.	.
cord-048466-fj9l8che	205	1	Residues	residue	NNS
cord-048466-fj9l8che	205	2	in	in	IN
cord-048466-fj9l8che	205	3	antigenic	antigenic	JJ
cord-048466-fj9l8che	205	4	epitopes	epitope	NNS
cord-048466-fj9l8che	205	5	were	be	VBD
cord-048466-fj9l8che	205	6	collected	collect	VBN
cord-048466-fj9l8che	205	7	from	from	IN
cord-048466-fj9l8che	205	8	several	several	JJ
cord-048466-fj9l8che	205	9	references	reference	NNS
cord-048466-fj9l8che	205	10	[	[	-LRB-
cord-048466-fj9l8che	205	11	9	9	CD
cord-048466-fj9l8che	205	12	,	,	,
cord-048466-fj9l8che	205	13	13	13	CD
cord-048466-fj9l8che	205	14	,	,	,
cord-048466-fj9l8che	205	15	39	39	CD
cord-048466-fj9l8che	205	16	,	,	,
cord-048466-fj9l8che	205	17	40	40	CD
cord-048466-fj9l8che	205	18	,	,	,
cord-048466-fj9l8che	205	19	48	48	CD
cord-048466-fj9l8che	205	20	,	,	,
cord-048466-fj9l8che	205	21	[	[	-LRB-
cord-048466-fj9l8che	205	22	78	78	CD
cord-048466-fj9l8che	205	23	]	]	-RRB-
cord-048466-fj9l8che	205	24	[	[	-LRB-
cord-048466-fj9l8che	205	25	79	79	CD
cord-048466-fj9l8che	205	26	]	]	-RRB-
cord-048466-fj9l8che	205	27	[	[	-LRB-
cord-048466-fj9l8che	205	28	80	80	CD
cord-048466-fj9l8che	205	29	]	]	-RRB-
cord-048466-fj9l8che	205	30	[	[	-LRB-
cord-048466-fj9l8che	205	31	81	81	CD
cord-048466-fj9l8che	205	32	]	]	-RRB-
cord-048466-fj9l8che	205	33	[	[	-LRB-
cord-048466-fj9l8che	205	34	82	82	CD
cord-048466-fj9l8che	205	35	]	]	-RRB-
cord-048466-fj9l8che	206	1	[	[	-LRB-
cord-048466-fj9l8che	206	2	83	83	CD
cord-048466-fj9l8che	206	3	]	]	-RRB-
cord-048466-fj9l8che	206	4	83	83	CD
cord-048466-fj9l8che	206	5	,	,	,
cord-048466-fj9l8che	206	6	84	84	CD
cord-048466-fj9l8che	206	7	]	]	-RRB-
cord-048466-fj9l8che	206	8	.	.	.
cord-048466-fj9l8che	207	1	Influenza	influenza	NN
cord-048466-fj9l8che	207	2	:	:	:
cord-048466-fj9l8che	208	1	the	the	DT
cord-048466-fj9l8che	208	2	Mother	Mother	NNP
cord-048466-fj9l8che	208	3	of	of	IN
cord-048466-fj9l8che	208	4	All	all	DT
cord-048466-fj9l8che	208	5	Pandemics	Pandemics	NNPS
cord-048466-fj9l8che	208	6	Recent	recent	JJ
cord-048466-fj9l8che	208	7	changes	change	NNS
cord-048466-fj9l8che	208	8	among	among	IN
cord-048466-fj9l8che	208	9	human	human	JJ
cord-048466-fj9l8che	208	10	influenza	influenza	NN
cord-048466-fj9l8che	208	11	viruses	virus	NNS
cord-048466-fj9l8che	208	12	Mild	mild	JJ
cord-048466-fj9l8che	208	13	to	to	TO
cord-048466-fj9l8che	208	14	moderate	moderate	JJ
cord-048466-fj9l8che	208	15	influenza	influenza	NN
cord-048466-fj9l8che	208	16	activity	activity	NN
cord-048466-fj9l8che	208	17	in	in	IN
cord-048466-fj9l8che	208	18	Europe	Europe	NNP
cord-048466-fj9l8che	208	19	and	and	CC
cord-048466-fj9l8che	208	20	the	the	DT
cord-048466-fj9l8che	208	21	detection	detection	NN
cord-048466-fj9l8che	208	22	of	of	IN
cord-048466-fj9l8che	208	23	novel	novel	NN
cord-048466-fj9l8che	208	24	A(H1N2	A(H1N2	NNP
cord-048466-fj9l8che	208	25	)	)	-RRB-
cord-048466-fj9l8che	208	26	and	and	CC
cord-048466-fj9l8che	208	27	B	b	NN
cord-048466-fj9l8che	208	28	viruses	virus	NNS
cord-048466-fj9l8che	208	29	during	during	IN
cord-048466-fj9l8che	208	30	the	the	DT
cord-048466-fj9l8che	208	31	winter	winter	NN
cord-048466-fj9l8che	208	32	of	of	IN
cord-048466-fj9l8che	208	33	2001	2001	CD
cord-048466-fj9l8che	208	34	-	-	SYM
cord-048466-fj9l8che	208	35	02	02	CD
cord-048466-fj9l8che	208	36	Influenza	Influenza	NNP
cord-048466-fj9l8che	208	37	AH1N2	AH1N2	NNP
cord-048466-fj9l8che	208	38	viruses	virus	NNS
cord-048466-fj9l8che	208	39	,	,	,
cord-048466-fj9l8che	208	40	United	United	NNP
cord-048466-fj9l8che	208	41	Kingdom	Kingdom	NNP
cord-048466-fj9l8che	208	42	,	,	,
cord-048466-fj9l8che	208	43	2001	2001	CD
cord-048466-fj9l8che	208	44	-	-	SYM
cord-048466-fj9l8che	208	45	02	02	CD
cord-048466-fj9l8che	208	46	influenza	influenza	NN
cord-048466-fj9l8che	208	47	season	season	NN
cord-048466-fj9l8che	208	48	Molecular	Molecular	NNP
cord-048466-fj9l8che	208	49	Evolution	Evolution	NNP
cord-048466-fj9l8che	208	50	of	of	IN
cord-048466-fj9l8che	208	51	Human	Human	NNP
cord-048466-fj9l8che	208	52	Influenza	Influenza	NNP
cord-048466-fj9l8che	208	53	A	A	NNP
cord-048466-fj9l8che	208	54	/	/	SYM
cord-048466-fj9l8che	208	55	H3N2	H3N2	NNP
cord-048466-fj9l8che	208	56	Virus	Virus	NNP
cord-048466-fj9l8che	208	57	in	in	IN
cord-048466-fj9l8che	208	58	Asia	Asia	NNP
cord-048466-fj9l8che	208	59	adn	adn	NNP
cord-048466-fj9l8che	208	60	Europe	Europe	NNP
cord-048466-fj9l8che	208	61	from	from	IN
cord-048466-fj9l8che	208	62	An	an	DT
cord-048466-fj9l8che	208	63	Influenza	Influenza	NNP
cord-048466-fj9l8che	208	64	A	A	NNP
cord-048466-fj9l8che	208	65	(	(	-LRB-
cord-048466-fj9l8che	208	66	H3	H3	NNP
cord-048466-fj9l8che	208	67	)	)	-RRB-
cord-048466-fj9l8che	208	68	Reassortant	Reassortant	NNP
cord-048466-fj9l8che	208	69	Was	be	VBD
cord-048466-fj9l8che	208	70	Epidemic	epidemic	NN
cord-048466-fj9l8che	208	71	in	in	IN
cord-048466-fj9l8che	208	72	Australia	Australia	NNP
cord-048466-fj9l8che	208	73	and	and	CC
cord-048466-fj9l8che	208	74	New	New	NNP
cord-048466-fj9l8che	208	75	Zealand	Zealand	NNP
cord-048466-fj9l8che	208	76	in	in	IN
cord-048466-fj9l8che	208	77	2003	2003	CD
cord-048466-fj9l8che	208	78	Large	large	JJ
cord-048466-fj9l8che	208	79	-	-	HYPH
cord-048466-fj9l8che	208	80	scale	scale	NN
cord-048466-fj9l8che	208	81	sequencing	sequencing	NN
cord-048466-fj9l8che	208	82	of	of	IN
cord-048466-fj9l8che	208	83	human	human	JJ
cord-048466-fj9l8che	208	84	influenza	influenza	NN
cord-048466-fj9l8che	209	1	reveals	reveal	VBZ
cord-048466-fj9l8che	209	2	the	the	DT
cord-048466-fj9l8che	209	3	dynamic	dynamic	JJ
cord-048466-fj9l8che	209	4	nature	nature	NN
cord-048466-fj9l8che	209	5	of	of	IN
cord-048466-fj9l8che	209	6	viral	viral	JJ
cord-048466-fj9l8che	209	7	genome	genome	NN
cord-048466-fj9l8che	209	8	evolution	evolution	NN
cord-048466-fj9l8che	210	1	The	the	DT
cord-048466-fj9l8che	210	2	value	value	NN
cord-048466-fj9l8che	210	3	of	of	IN
cord-048466-fj9l8che	210	4	a	a	DT
cord-048466-fj9l8che	210	5	database	database	NN
cord-048466-fj9l8che	210	6	in	in	IN
cord-048466-fj9l8che	210	7	surveillance	surveillance	NN
cord-048466-fj9l8che	210	8	and	and	CC
cord-048466-fj9l8che	210	9	vaccine	vaccine	NN
cord-048466-fj9l8che	210	10	selection	selection	NN
cord-048466-fj9l8che	210	11	Egg	egg	NN
cord-048466-fj9l8che	210	12	fluids	fluid	NNS
cord-048466-fj9l8che	210	13	and	and	CC
cord-048466-fj9l8che	210	14	cells	cell	NNS
cord-048466-fj9l8che	210	15	of	of	IN
cord-048466-fj9l8che	210	16	the	the	DT
cord-048466-fj9l8che	210	17	chorioallantoic	chorioallantoic	NNP
cord-048466-fj9l8che	210	18	membrane	membrane	NN
cord-048466-fj9l8che	210	19	of	of	IN
cord-048466-fj9l8che	210	20	embryonated	embryonate	VBN
cord-048466-fj9l8che	210	21	chicken	chicken	NN
cord-048466-fj9l8che	210	22	eggs	egg	NNS
cord-048466-fj9l8che	210	23	can	can	MD
cord-048466-fj9l8che	210	24	select	select	VB
cord-048466-fj9l8che	210	25	different	different	JJ
cord-048466-fj9l8che	210	26	variants	variant	NNS
cord-048466-fj9l8che	210	27	of	of	IN
cord-048466-fj9l8che	210	28	influenza	influenza	NN
cord-048466-fj9l8che	210	29	A	a	NN
cord-048466-fj9l8che	210	30	(	(	-LRB-
cord-048466-fj9l8che	210	31	H3N2	H3N2	NNP
cord-048466-fj9l8che	210	32	)	)	-RRB-
cord-048466-fj9l8che	210	33	viruses	virus	NNS
cord-048466-fj9l8che	211	1	Natural	Natural	NNP
cord-048466-fj9l8che	211	2	Selection	Selection	NNP
cord-048466-fj9l8che	211	3	on	on	IN
cord-048466-fj9l8che	211	4	the	the	DT
cord-048466-fj9l8che	211	5	Influenza	Influenza	NNP
cord-048466-fj9l8che	211	6	Virus	Virus	NNP
cord-048466-fj9l8che	211	7	Genome	Genome	NNP
cord-048466-fj9l8che	211	8	Human	Human	NNP
cord-048466-fj9l8che	211	9	memory	memory	NN
cord-048466-fj9l8che	211	10	CTL	CTL	NNP
cord-048466-fj9l8che	211	11	response	response	NN
cord-048466-fj9l8che	211	12	specific	specific	JJ
cord-048466-fj9l8che	211	13	for	for	IN
cord-048466-fj9l8che	211	14	influenza	influenza	NN
cord-048466-fj9l8che	211	15	A	a	DT
cord-048466-fj9l8che	211	16	virus	virus	NN
cord-048466-fj9l8che	211	17	is	be	VBZ
cord-048466-fj9l8che	211	18	broad	broad	JJ
cord-048466-fj9l8che	211	19	and	and	CC
cord-048466-fj9l8che	211	20	multispecific	multispecific	JJ
cord-048466-fj9l8che	212	1	Influenza	Influenza	NNP
cord-048466-fj9l8che	212	2	A	A	NNP
cord-048466-fj9l8che	213	1	Virus	Virus	NNP
cord-048466-fj9l8che	213	2	Neuraminidase	Neuraminidase	NNP
cord-048466-fj9l8che	213	3	:	:	:
cord-048466-fj9l8che	213	4	Regions	region	NNS
cord-048466-fj9l8che	213	5	of	of	IN
cord-048466-fj9l8che	213	6	the	the	DT
cord-048466-fj9l8che	213	7	Protein	Protein	NNP
cord-048466-fj9l8che	213	8	Potentially	potentially	RB
cord-048466-fj9l8che	213	9	Involved	involve	VBN
cord-048466-fj9l8che	213	10	in	in	IN
cord-048466-fj9l8che	213	11	Virus	Virus	NNP
cord-048466-fj9l8che	213	12	-	-	HYPH
cord-048466-fj9l8che	213	13	Host	Host	NNP
cord-048466-fj9l8che	213	14	Interactions	Interactions	NNPS
cord-048466-fj9l8che	213	15	CTL	CTL	NNP
cord-048466-fj9l8che	213	16	epitopes	epitope	NNS
cord-048466-fj9l8che	213	17	for	for	IN
cord-048466-fj9l8che	213	18	influenza	influenza	NN
cord-048466-fj9l8che	213	19	A	a	DT
cord-048466-fj9l8che	213	20	including	include	VBG
cord-048466-fj9l8che	213	21	the	the	DT
cord-048466-fj9l8che	213	22	H5N1	H5N1	NNP
cord-048466-fj9l8che	213	23	bird	bird	NN
cord-048466-fj9l8che	213	24	flu	flu	NN
cord-048466-fj9l8che	213	25	;	;	:
cord-048466-fj9l8che	213	26	genome-	genome-	NN
cord-048466-fj9l8che	213	27	,	,	,
cord-048466-fj9l8che	213	28	pathogen-	pathogen-	JJ
cord-048466-fj9l8che	213	29	,	,	,
cord-048466-fj9l8che	213	30	and	and	CC
cord-048466-fj9l8che	213	31	HLA	HLA	NNP
cord-048466-fj9l8che	213	32	-	-	HYPH
cord-048466-fj9l8che	213	33	wide	wide	JJ
cord-048466-fj9l8che	213	34	screening	screening	NN
cord-048466-fj9l8che	213	35	HLA	HLA	NNP
cord-048466-fj9l8che	213	36	-	-	HYPH
cord-048466-fj9l8che	213	37	A1	A1	NNP
cord-048466-fj9l8che	213	38	and	and	CC
cord-048466-fj9l8che	213	39	HLA	HLA	NNP
cord-048466-fj9l8che	213	40	-	-	HYPH
cord-048466-fj9l8che	213	41	A3	A3	NNP
cord-048466-fj9l8che	213	42	T	T	NNP
cord-048466-fj9l8che	213	43	cell	cell	NN
cord-048466-fj9l8che	213	44	epitopes	epitope	NNS
cord-048466-fj9l8che	213	45	derived	derive	VBN
cord-048466-fj9l8che	213	46	from	from	IN
cord-048466-fj9l8che	213	47	influenza	influenza	NN
cord-048466-fj9l8che	213	48	virus	virus	NN
cord-048466-fj9l8che	213	49	proteins	protein	NNS
cord-048466-fj9l8che	213	50	predicted	predict	VBN
cord-048466-fj9l8che	213	51	from	from	IN
cord-048466-fj9l8che	213	52	peptide	peptide	NN
cord-048466-fj9l8che	213	53	binding	binding	NN
cord-048466-fj9l8che	213	54	motifs	motif	NNS
cord-048466-fj9l8che	214	1	Different	different	JJ
cord-048466-fj9l8che	214	2	length	length	NN
cord-048466-fj9l8che	214	3	peptides	peptide	NNS
cord-048466-fj9l8che	214	4	bind	bind	VBP
cord-048466-fj9l8che	214	5	to	to	IN
cord-048466-fj9l8che	214	6	HLA	HLA	NNP
cord-048466-fj9l8che	214	7	-	-	HYPH
cord-048466-fj9l8che	214	8	Aw68	Aw68	NNP
cord-048466-fj9l8che	214	9	similarly	similarly	RB
cord-048466-fj9l8che	214	10	at	at	IN
cord-048466-fj9l8che	214	11	their	-PRON-	PRP$
cord-048466-fj9l8che	214	12	ends	end	NNS
cord-048466-fj9l8che	214	13	but	but	CC
cord-048466-fj9l8che	214	14	bulge	bulge	VBP
cord-048466-fj9l8che	214	15	out	out	RP
cord-048466-fj9l8che	214	16	in	in	IN
cord-048466-fj9l8che	214	17	the	the	DT
cord-048466-fj9l8che	214	18	middle	middle	JJ
cord-048466-fj9l8che	214	19	Assessment	Assessment	NNP
cord-048466-fj9l8che	214	20	of	of	IN
cord-048466-fj9l8che	214	21	the	the	DT
cord-048466-fj9l8che	214	22	extent	extent	NN
cord-048466-fj9l8che	214	23	of	of	IN
cord-048466-fj9l8che	214	24	variation	variation	NN
cord-048466-fj9l8che	214	25	in	in	IN
cord-048466-fj9l8che	214	26	influenza	influenza	NN
cord-048466-fj9l8che	214	27	A	a	DT
cord-048466-fj9l8che	214	28	virus	virus	NN
cord-048466-fj9l8che	214	29	cytotoxic	cytotoxic	JJ
cord-048466-fj9l8che	214	30	T	t	NN
cord-048466-fj9l8che	214	31	-	-	HYPH
cord-048466-fj9l8che	214	32	lymphocyte	lymphocyte	NN
cord-048466-fj9l8che	214	33	epitopes	epitope	NNS
cord-048466-fj9l8che	214	34	by	by	IN
cord-048466-fj9l8che	214	35	using	use	VBG
cord-048466-fj9l8che	214	36	virus	virus	NN
cord-048466-fj9l8che	214	37	-	-	HYPH
cord-048466-fj9l8che	214	38	specific	specific	JJ
cord-048466-fj9l8che	214	39	CD8	CD8	NNP
cord-048466-fj9l8che	214	40	+	+	CC
cord-048466-fj9l8che	214	41	T	t	NN
cord-048466-fj9l8che	214	42	-	-	HYPH
cord-048466-fj9l8che	214	43	cell	cell	NN
cord-048466-fj9l8che	214	44	clones	clone	NNS
cord-048466-fj9l8che	215	1	The	the	DT
cord-048466-fj9l8che	215	2	HLA	HLA	NNP
cord-048466-fj9l8che	215	3	-	-	HYPH
cord-048466-fj9l8che	215	4	B14	b14	NN
cord-048466-fj9l8che	215	5	peptide	peptide	NN
cord-048466-fj9l8che	215	6	binding	binding	NN
cord-048466-fj9l8che	215	7	site	site	NN
cord-048466-fj9l8che	215	8	can	can	MD
cord-048466-fj9l8che	215	9	accommodate	accommodate	VB
cord-048466-fj9l8che	215	10	peptides	peptide	NNS
cord-048466-fj9l8che	215	11	with	with	IN
cord-048466-fj9l8che	215	12	different	different	JJ
cord-048466-fj9l8che	215	13	combinations	combination	NNS
cord-048466-fj9l8che	215	14	of	of	IN
cord-048466-fj9l8che	215	15	anchor	anchor	NN
cord-048466-fj9l8che	215	16	residues	residue	NNS
cord-048466-fj9l8che	216	1	The	the	DT
cord-048466-fj9l8che	216	2	peptide	peptide	NN
cord-048466-fj9l8che	216	3	binding	bind	VBG
cord-048466-fj9l8che	216	4	motif	motif	NN
cord-048466-fj9l8che	216	5	of	of	IN
cord-048466-fj9l8che	216	6	the	the	DT
cord-048466-fj9l8che	216	7	disease	disease	NN
cord-048466-fj9l8che	216	8	associated	associate	VBD
cord-048466-fj9l8che	216	9	HLA	HLA	NNP
cord-048466-fj9l8che	216	10	-	-	HYPH
cord-048466-fj9l8che	216	11	DQ	DQ	NNP
cord-048466-fj9l8che	216	12	(	(	-LRB-
cord-048466-fj9l8che	216	13	alpha	alpha	NN
cord-048466-fj9l8che	216	14	1	1	CD
cord-048466-fj9l8che	217	1	*	*	NFP
cord-048466-fj9l8che	217	2	0501	0501	CD
cord-048466-fj9l8che	218	1	,	,	,
cord-048466-fj9l8che	218	2	beta	beta	NN
cord-048466-fj9l8che	218	3	1	1	CD
cord-048466-fj9l8che	218	4	*	*	NFP
cord-048466-fj9l8che	218	5	0201	0201	CD
cord-048466-fj9l8che	218	6	)	)	-RRB-
cord-048466-fj9l8che	218	7	molecule	molecule	NN
cord-048466-fj9l8che	218	8	HLA	HLA	NNP
cord-048466-fj9l8che	218	9	-	-	HYPH
cord-048466-fj9l8che	218	10	B*0702	B*0702	NNP
cord-048466-fj9l8che	218	11	transgenic	transgenic	NN
cord-048466-fj9l8che	218	12	,	,	,
cord-048466-fj9l8che	218	13	H-2KbDb	h-2kbdb	JJ
cord-048466-fj9l8che	218	14	doubleknockout	doubleknockout	NN
cord-048466-fj9l8che	218	15	mice	mouse	NNS
cord-048466-fj9l8che	218	16	:	:	:
cord-048466-fj9l8che	218	17	phenotypical	phenotypical	JJ
cord-048466-fj9l8che	218	18	and	and	CC
cord-048466-fj9l8che	218	19	functional	functional	JJ
cord-048466-fj9l8che	218	20	characterization	characterization	NN
cord-048466-fj9l8che	218	21	in	in	IN
cord-048466-fj9l8che	218	22	response	response	NN
cord-048466-fj9l8che	218	23	to	to	IN
cord-048466-fj9l8che	218	24	influenza	influenza	NN
cord-048466-fj9l8che	218	25	virus	virus	NN
cord-048466-fj9l8che	218	26	Incidence	incidence	NN
cord-048466-fj9l8che	218	27	of	of	IN
cord-048466-fj9l8che	218	28	adamantane	adamantane	NNP
cord-048466-fj9l8che	218	29	resistance	resistance	NN
cord-048466-fj9l8che	218	30	among	among	IN
cord-048466-fj9l8che	218	31	influenza	influenza	NN
cord-048466-fj9l8che	218	32	A	a	NN
cord-048466-fj9l8che	218	33	(	(	-LRB-
cord-048466-fj9l8che	218	34	H3N2	H3N2	NNP
cord-048466-fj9l8che	218	35	)	)	-RRB-
cord-048466-fj9l8che	218	36	viruses	virus	NNS
cord-048466-fj9l8che	218	37	isolated	isolate	VBN
cord-048466-fj9l8che	218	38	worldwide	worldwide	RB
cord-048466-fj9l8che	218	39	from	from	IN
cord-048466-fj9l8che	218	40	1994	1994	CD
cord-048466-fj9l8che	218	41	to	to	IN
cord-048466-fj9l8che	218	42	2005	2005	CD
cord-048466-fj9l8che	218	43	:	:	:
cord-048466-fj9l8che	218	44	a	a	DT
cord-048466-fj9l8che	218	45	cause	cause	NN
cord-048466-fj9l8che	218	46	for	for	IN
cord-048466-fj9l8che	218	47	concern	concern	NN
cord-048466-fj9l8che	218	48	Molecular	molecular	JJ
cord-048466-fj9l8che	218	49	basis	basis	NN
cord-048466-fj9l8che	218	50	of	of	IN
cord-048466-fj9l8che	218	51	resistance	resistance	NN
cord-048466-fj9l8che	218	52	of	of	IN
cord-048466-fj9l8che	218	53	influenza	influenza	NN
cord-048466-fj9l8che	218	54	A	a	DT
cord-048466-fj9l8che	218	55	viruses	virus	NNS
cord-048466-fj9l8che	218	56	to	to	IN
cord-048466-fj9l8che	218	57	amantadine	amantadine	NNP
cord-048466-fj9l8che	218	58	Human	Human	NNP
cord-048466-fj9l8che	218	59	CD8	CD8	NNP
cord-048466-fj9l8che	218	60	+	+	CC
cord-048466-fj9l8che	218	61	and	and	CC
cord-048466-fj9l8che	218	62	CD4	CD4	NNP
cord-048466-fj9l8che	218	63	+	+	CC
cord-048466-fj9l8che	218	64	T	T	NNP
cord-048466-fj9l8che	218	65	lymphocyte	lymphocyte	NN
cord-048466-fj9l8che	218	66	memory	memory	NN
cord-048466-fj9l8che	218	67	to	to	IN
cord-048466-fj9l8che	218	68	influenza	influenza	NN
cord-048466-fj9l8che	218	69	A	a	DT
cord-048466-fj9l8che	218	70	viruses	virus	NNS
cord-048466-fj9l8che	218	71	of	of	IN
cord-048466-fj9l8che	218	72	swine	swine	NN
cord-048466-fj9l8che	218	73	and	and	CC
cord-048466-fj9l8che	218	74	avian	avian	JJ
cord-048466-fj9l8che	218	75	species	specie	NNS
cord-048466-fj9l8che	218	76	Identification	identification	NN
cord-048466-fj9l8che	218	77	of	of	IN
cord-048466-fj9l8che	218	78	the	the	DT
cord-048466-fj9l8che	218	79	peptide	peptide	NN
cord-048466-fj9l8che	218	80	binding	binding	NN
cord-048466-fj9l8che	218	81	motif	motif	NN
cord-048466-fj9l8che	218	82	for	for	IN
cord-048466-fj9l8che	218	83	HLA	HLA	NNP
cord-048466-fj9l8che	218	84	-	-	HYPH
cord-048466-fj9l8che	218	85	B44	B44	NNP
cord-048466-fj9l8che	218	86	,	,	,
cord-048466-fj9l8che	218	87	one	one	CD
cord-048466-fj9l8che	218	88	of	of	IN
cord-048466-fj9l8che	218	89	the	the	DT
cord-048466-fj9l8che	218	90	most	most	RBS
cord-048466-fj9l8che	218	91	common	common	JJ
cord-048466-fj9l8che	218	92	HLA	HLA	NNP
cord-048466-fj9l8che	218	93	-	-	HYPH
cord-048466-fj9l8che	218	94	B	B	NNP
cord-048466-fj9l8che	218	95	alleles	allele	NNS
cord-048466-fj9l8che	218	96	in	in	IN
cord-048466-fj9l8che	218	97	the	the	DT
cord-048466-fj9l8che	218	98	Caucasian	caucasian	JJ
cord-048466-fj9l8che	218	99	population	population	NN
cord-048466-fj9l8che	218	100	Emergence	emergence	NN
cord-048466-fj9l8che	218	101	of	of	IN
cord-048466-fj9l8che	218	102	Influenza	Influenza	NNP
cord-048466-fj9l8che	218	103	A	A	NNP
cord-048466-fj9l8che	218	104	H1N2	H1N2	NNP
cord-048466-fj9l8che	218	105	Reassortant	Reassortant	NNP
cord-048466-fj9l8che	218	106	Viruses	virus	NNS
cord-048466-fj9l8che	218	107	in	in	IN
cord-048466-fj9l8che	218	108	the	the	DT
cord-048466-fj9l8che	218	109	Human	Human	NNP
cord-048466-fj9l8che	218	110	Population	Population	NNP
cord-048466-fj9l8che	218	111	during	during	IN
cord-048466-fj9l8che	218	112	Intercontinental	intercontinental	JJ
cord-048466-fj9l8che	218	113	circulation	circulation	NN
cord-048466-fj9l8che	218	114	of	of	IN
cord-048466-fj9l8che	218	115	human	human	JJ
cord-048466-fj9l8che	218	116	influenza	influenza	NN
cord-048466-fj9l8che	218	117	A(H1N2	A(H1N2	NNP
cord-048466-fj9l8che	218	118	)	)	-RRB-
cord-048466-fj9l8che	218	119	reassortant	reassortant	JJ
cord-048466-fj9l8che	218	120	viruses	virus	NNS
cord-048466-fj9l8che	218	121	during	during	IN
cord-048466-fj9l8che	218	122	the	the	DT
cord-048466-fj9l8che	218	123	2001	2001	CD
cord-048466-fj9l8che	218	124	-	-	SYM
cord-048466-fj9l8che	218	125	2002	2002	CD
cord-048466-fj9l8che	218	126	influenza	influenza	NN
cord-048466-fj9l8che	218	127	season	season	NN
cord-048466-fj9l8che	218	128	Phylogenetic	Phylogenetic	NNP
cord-048466-fj9l8che	218	129	analysis	analysis	NN
cord-048466-fj9l8che	218	130	of	of	IN
cord-048466-fj9l8che	218	131	the	the	DT
cord-048466-fj9l8che	218	132	entire	entire	JJ
cord-048466-fj9l8che	218	133	genome	genome	NN
cord-048466-fj9l8che	218	134	of	of	IN
cord-048466-fj9l8che	218	135	influenza	influenza	NN
cord-048466-fj9l8che	218	136	A	a	NN
cord-048466-fj9l8che	218	137	(	(	-LRB-
cord-048466-fj9l8che	218	138	H3N2	H3N2	NNP
cord-048466-fj9l8che	218	139	)	)	-RRB-
cord-048466-fj9l8che	218	140	viruses	virus	NNS
cord-048466-fj9l8che	218	141	from	from	IN
cord-048466-fj9l8che	218	142	Japan	Japan	NNP
cord-048466-fj9l8che	218	143	:	:	:
cord-048466-fj9l8che	218	144	evidence	evidence	NN
cord-048466-fj9l8che	218	145	for	for	IN
cord-048466-fj9l8che	218	146	genetic	genetic	JJ
cord-048466-fj9l8che	218	147	reassortment	reassortment	NN
cord-048466-fj9l8che	218	148	of	of	IN
cord-048466-fj9l8che	218	149	the	the	DT
cord-048466-fj9l8che	218	150	six	six	CD
cord-048466-fj9l8che	218	151	internal	internal	JJ
cord-048466-fj9l8che	218	152	genes	gene	NNS
cord-048466-fj9l8che	218	153	Wholegenome	Wholegenome	NNP
cord-048466-fj9l8che	218	154	analysis	analysis	NN
cord-048466-fj9l8che	218	155	of	of	IN
cord-048466-fj9l8che	218	156	human	human	JJ
cord-048466-fj9l8che	218	157	influenza	influenza	NN
cord-048466-fj9l8che	218	158	A	a	DT
cord-048466-fj9l8che	218	159	virus	virus	NN
cord-048466-fj9l8che	218	160	reveales	reveal	VBZ
cord-048466-fj9l8che	218	161	multiple	multiple	JJ
cord-048466-fj9l8che	218	162	persistent	persistent	JJ
cord-048466-fj9l8che	218	163	lineages	lineage	NNS
cord-048466-fj9l8che	218	164	and	and	CC
cord-048466-fj9l8che	218	165	reassortment	reassortment	NN
cord-048466-fj9l8che	218	166	among	among	IN
cord-048466-fj9l8che	218	167	recent	recent	JJ
cord-048466-fj9l8che	218	168	H3N2	H3N2	NNP
cord-048466-fj9l8che	218	169	viruses	virus	NNS
cord-048466-fj9l8che	219	1	Preliminary	preliminary	JJ
cord-048466-fj9l8che	219	2	assessment	assessment	NN
cord-048466-fj9l8che	219	3	of	of	IN
cord-048466-fj9l8che	219	4	the	the	DT
cord-048466-fj9l8che	219	5	effectiveness	effectiveness	NN
cord-048466-fj9l8che	219	6	of	of	IN
cord-048466-fj9l8che	219	7	the	the	DT
cord-048466-fj9l8che	219	8	2003	2003	CD
cord-048466-fj9l8che	219	9	-	-	SYM
cord-048466-fj9l8che	219	10	04	04	CD
cord-048466-fj9l8che	219	11	inactivated	inactivate	VBN
cord-048466-fj9l8che	219	12	influenza	influenza	NN
cord-048466-fj9l8che	219	13	vaccine	vaccine	NN
cord-048466-fj9l8che	219	14	--	--	:
cord-048466-fj9l8che	219	15	Colorado	Colorado	NNP
cord-048466-fj9l8che	219	16	Mismatched	mismatched	JJ
cord-048466-fj9l8che	219	17	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	219	18	and	and	CC
cord-048466-fj9l8che	219	19	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	219	20	specificities	specificity	NNS
cord-048466-fj9l8che	219	21	in	in	IN
cord-048466-fj9l8che	219	22	recent	recent	JJ
cord-048466-fj9l8che	219	23	human	human	JJ
cord-048466-fj9l8che	219	24	H3N2	H3N2	NNP
cord-048466-fj9l8che	219	25	influenza	influenza	NN
cord-048466-fj9l8che	219	26	viruses	virus	NNS
cord-048466-fj9l8che	219	27	Genetic	genetic	JJ
cord-048466-fj9l8che	219	28	and	and	CC
cord-048466-fj9l8che	219	29	antigenic	antigenic	JJ
cord-048466-fj9l8che	219	30	analysis	analysis	NN
cord-048466-fj9l8che	219	31	of	of	IN
cord-048466-fj9l8che	219	32	the	the	DT
cord-048466-fj9l8che	219	33	first	first	JJ
cord-048466-fj9l8che	219	34	A	A	NNP
cord-048466-fj9l8che	219	35	/	/	SYM
cord-048466-fj9l8che	219	36	New	New	NNP
cord-048466-fj9l8che	219	37	Caledonia/20/99-like	Caledonia/20/99-like	NNP
cord-048466-fj9l8che	220	1	H1N1	H1N1	NNP
cord-048466-fj9l8che	220	2	influenza	influenza	NN
cord-048466-fj9l8che	220	3	isolates	isolate	VBZ
cord-048466-fj9l8che	220	4	reported	report	VBN
cord-048466-fj9l8che	220	5	in	in	IN
cord-048466-fj9l8che	220	6	the	the	DT
cord-048466-fj9l8che	220	7	Americas	Americas	NNP
cord-048466-fj9l8che	220	8	Organization	Organization	NNP
cord-048466-fj9l8che	220	9	WH	WH	NNP
cord-048466-fj9l8che	220	10	:	:	:
cord-048466-fj9l8che	221	1	Recommended	recommend	VBN
cord-048466-fj9l8che	221	2	composition	composition	NN
cord-048466-fj9l8che	221	3	of	of	IN
cord-048466-fj9l8che	221	4	influenza	influenza	NN
cord-048466-fj9l8che	221	5	virus	virus	NN
cord-048466-fj9l8che	221	6	vaccines	vaccine	NNS
cord-048466-fj9l8che	221	7	for	for	IN
cord-048466-fj9l8che	221	8	use	use	NN
cord-048466-fj9l8che	221	9	in	in	IN
cord-048466-fj9l8che	221	10	the	the	DT
cord-048466-fj9l8che	221	11	2000	2000	CD
cord-048466-fj9l8che	221	12	-	-	SYM
cord-048466-fj9l8che	221	13	2001	2001	CD
cord-048466-fj9l8che	221	14	season	season	NN
cord-048466-fj9l8che	221	15	Structural	structural	JJ
cord-048466-fj9l8che	221	16	identification	identification	NN
cord-048466-fj9l8che	221	17	of	of	IN
cord-048466-fj9l8che	221	18	the	the	DT
cord-048466-fj9l8che	221	19	antibody	antibody	NN
cord-048466-fj9l8che	221	20	-	-	HYPH
cord-048466-fj9l8che	221	21	binding	bind	VBG
cord-048466-fj9l8che	221	22	sites	site	NNS
cord-048466-fj9l8che	221	23	of	of	IN
cord-048466-fj9l8che	221	24	Hong	Hong	NNP
cord-048466-fj9l8che	221	25	Kong	Kong	NNP
cord-048466-fj9l8che	221	26	influenza	influenza	NN
cord-048466-fj9l8che	221	27	haemagglutinin	haemagglutinin	NNP
cord-048466-fj9l8che	221	28	and	and	CC
cord-048466-fj9l8che	221	29	their	-PRON-	PRP$
cord-048466-fj9l8che	221	30	involvement	involvement	NN
cord-048466-fj9l8che	221	31	in	in	IN
cord-048466-fj9l8che	221	32	antigenic	antigenic	JJ
cord-048466-fj9l8che	221	33	variation	variation	NN
cord-048466-fj9l8che	221	34	Comparative	Comparative	NNP
cord-048466-fj9l8che	221	35	Analyses	Analyses	NNPS
cord-048466-fj9l8che	221	36	of	of	IN
cord-048466-fj9l8che	221	37	the	the	DT
cord-048466-fj9l8che	221	38	Specificities	Specificities	NNPS
cord-048466-fj9l8che	221	39	of	of	IN
cord-048466-fj9l8che	221	40	Anti	Anti	NNP
cord-048466-fj9l8che	221	41	-	-	JJ
cord-048466-fj9l8che	221	42	Influenza	influenza	JJ
cord-048466-fj9l8che	221	43	Hemagglutinin	Hemagglutinin	NNP
cord-048466-fj9l8che	221	44	Antibodies	Antibodies	NNPS
cord-048466-fj9l8che	221	45	in	in	IN
cord-048466-fj9l8che	221	46	Human	Human	NNP
cord-048466-fj9l8che	221	47	Sera	Sera	NNP
cord-048466-fj9l8che	221	48	Neutralization	Neutralization	NNP
cord-048466-fj9l8che	221	49	escape	escape	NN
cord-048466-fj9l8che	221	50	mutants	mutant	NNS
cord-048466-fj9l8che	221	51	of	of	IN
cord-048466-fj9l8che	221	52	type	type	NN
cord-048466-fj9l8che	221	53	A	a	DT
cord-048466-fj9l8che	221	54	influenza	influenza	NN
cord-048466-fj9l8che	221	55	virus	virus	NN
cord-048466-fj9l8che	221	56	are	be	VBP
cord-048466-fj9l8che	221	57	readily	readily	RB
cord-048466-fj9l8che	221	58	selected	select	VBN
cord-048466-fj9l8che	221	59	by	by	IN
cord-048466-fj9l8che	221	60	antisera	antisera	NN
cord-048466-fj9l8che	221	61	from	from	IN
cord-048466-fj9l8che	221	62	mice	mouse	NNS
cord-048466-fj9l8che	221	63	immunized	immunize	VBN
cord-048466-fj9l8che	221	64	with	with	IN
cord-048466-fj9l8che	221	65	whole	whole	JJ
cord-048466-fj9l8che	221	66	virus	virus	NN
cord-048466-fj9l8che	221	67	:	:	:
cord-048466-fj9l8che	221	68	a	a	DT
cord-048466-fj9l8che	221	69	possible	possible	JJ
cord-048466-fj9l8che	221	70	mechanism	mechanism	NN
cord-048466-fj9l8che	221	71	for	for	IN
cord-048466-fj9l8che	221	72	antigenic	antigenic	JJ
cord-048466-fj9l8che	221	73	drift	drift	NNP
cord-048466-fj9l8che	221	74	Annual	annual	JJ
cord-048466-fj9l8che	221	75	report	report	NN
cord-048466-fj9l8che	221	76	of	of	IN
cord-048466-fj9l8che	221	77	the	the	DT
cord-048466-fj9l8che	221	78	National	National	NNP
cord-048466-fj9l8che	221	79	Influenza	Influenza	NNP
cord-048466-fj9l8che	221	80	Surveillance	Surveillance	NNP
cord-048466-fj9l8che	221	81	Scheme	Scheme	NNP
cord-048466-fj9l8che	222	1	Two	two	CD
cord-048466-fj9l8che	222	2	residues	residue	NNS
cord-048466-fj9l8che	222	3	in	in	IN
cord-048466-fj9l8che	222	4	the	the	DT
cord-048466-fj9l8che	222	5	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	222	6	of	of	IN
cord-048466-fj9l8che	222	7	A	a	NN
cord-048466-fj9l8che	222	8	/	/	SYM
cord-048466-fj9l8che	222	9	Fujian/411/	fujian/411/	NN
cord-048466-fj9l8che	222	10	02-like	02-like	CD
cord-048466-fj9l8che	223	1	influenza	influenza	NN
cord-048466-fj9l8che	223	2	viruses	virus	NNS
cord-048466-fj9l8che	223	3	are	be	VBP
cord-048466-fj9l8che	223	4	responsible	responsible	JJ
cord-048466-fj9l8che	223	5	for	for	IN
cord-048466-fj9l8che	223	6	antigenic	antigenic	JJ
cord-048466-fj9l8che	223	7	drift	drift	NN
cord-048466-fj9l8che	223	8	from	from	IN
cord-048466-fj9l8che	223	9	A	a	NN
cord-048466-fj9l8che	224	1	/Panama/2007/99	/Panama/2007/99	NFP
cord-048466-fj9l8che	224	2	Mapping	map	VBG
cord-048466-fj9l8che	224	3	the	the	DT
cord-048466-fj9l8che	224	4	Antigenic	Antigenic	NNP
cord-048466-fj9l8che	224	5	and	and	CC
cord-048466-fj9l8che	224	6	Genetic	Genetic	NNP
cord-048466-fj9l8che	224	7	Evolution	Evolution	NNP
cord-048466-fj9l8che	224	8	of	of	IN
cord-048466-fj9l8che	224	9	Influenza	Influenza	NNP
cord-048466-fj9l8che	224	10	Virus	Virus	NNP
cord-048466-fj9l8che	224	11	Epitope	Epitope	NNP
cord-048466-fj9l8che	224	12	analysis	analysis	NN
cord-048466-fj9l8che	224	13	for	for	IN
cord-048466-fj9l8che	224	14	influenza	influenza	NN
cord-048466-fj9l8che	224	15	vaccine	vaccine	NN
cord-048466-fj9l8che	224	16	design	design	NN
cord-048466-fj9l8che	224	17	Structural	Structural	NNP
cord-048466-fj9l8che	224	18	Basis	Basis	NNP
cord-048466-fj9l8che	224	19	of	of	IN
cord-048466-fj9l8che	224	20	Immune	Immune	NNP
cord-048466-fj9l8che	224	21	Recognition	Recognition	NNP
cord-048466-fj9l8che	224	22	of	of	IN
cord-048466-fj9l8che	224	23	Influenza	Influenza	NNP
cord-048466-fj9l8che	224	24	Virus	Virus	NNP
cord-048466-fj9l8che	224	25	Hemagglutinin	Hemagglutinin	NNP
cord-048466-fj9l8che	224	26	Antibody	Antibody	NNP
cord-048466-fj9l8che	224	27	epitopes	epitope	NNS
cord-048466-fj9l8che	224	28	on	on	IN
cord-048466-fj9l8che	224	29	the	the	DT
cord-048466-fj9l8che	224	30	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	224	31	of	of	IN
cord-048466-fj9l8che	224	32	a	a	DT
cord-048466-fj9l8che	224	33	recent	recent	JJ
cord-048466-fj9l8che	224	34	H3N2	H3N2	NNP
cord-048466-fj9l8che	224	35	influenza	influenza	NN
cord-048466-fj9l8che	224	36	virus	virus	NN
cord-048466-fj9l8che	224	37	(	(	-LRB-
cord-048466-fj9l8che	224	38	A	a	NN
cord-048466-fj9l8che	224	39	/	/	SYM
cord-048466-fj9l8che	224	40	Memphis/31/98	memphis/31/98	CD
cord-048466-fj9l8che	224	41	)	)	-RRB-
cord-048466-fj9l8che	225	1	Monitoring	monitoring	NN
cord-048466-fj9l8che	225	2	of	of	IN
cord-048466-fj9l8che	225	3	viral	viral	JJ
cord-048466-fj9l8che	225	4	susceptibility	susceptibility	NN
cord-048466-fj9l8che	225	5	:	:	:
cord-048466-fj9l8che	225	6	new	new	JJ
cord-048466-fj9l8che	225	7	challenges	challenge	NNS
cord-048466-fj9l8che	225	8	with	with	IN
cord-048466-fj9l8che	225	9	the	the	DT
cord-048466-fj9l8che	225	10	development	development	NN
cord-048466-fj9l8che	225	11	of	of	IN
cord-048466-fj9l8che	225	12	influenza	influenza	NN
cord-048466-fj9l8che	225	13	NA	NA	NNP
cord-048466-fj9l8che	225	14	inhibitors	inhibitor	NNS
cord-048466-fj9l8che	226	1	Resistant	resistant	JJ
cord-048466-fj9l8che	227	1	influenza	influenza	NN
cord-048466-fj9l8che	227	2	A	a	DT
cord-048466-fj9l8che	227	3	viruses	virus	NNS
cord-048466-fj9l8che	227	4	in	in	IN
cord-048466-fj9l8che	227	5	children	child	NNS
cord-048466-fj9l8che	227	6	treated	treat	VBN
cord-048466-fj9l8che	227	7	with	with	IN
cord-048466-fj9l8che	227	8	oseltamivir	oseltamivir	NNP
cord-048466-fj9l8che	227	9	:	:	:
cord-048466-fj9l8che	227	10	descriptive	descriptive	JJ
cord-048466-fj9l8che	227	11	study	study	NN
cord-048466-fj9l8che	227	12	Detection	detection	NN
cord-048466-fj9l8che	227	13	of	of	IN
cord-048466-fj9l8che	227	14	amantadine	amantadine	NN
cord-048466-fj9l8che	227	15	-	-	HYPH
cord-048466-fj9l8che	227	16	resistant	resistant	JJ
cord-048466-fj9l8che	227	17	variants	variant	NNS
cord-048466-fj9l8che	227	18	among	among	IN
cord-048466-fj9l8che	227	19	avian	avian	JJ
cord-048466-fj9l8che	227	20	influenza	influenza	NN
cord-048466-fj9l8che	227	21	viruses	virus	NNS
cord-048466-fj9l8che	227	22	isolated	isolate	VBN
cord-048466-fj9l8che	227	23	in	in	IN
cord-048466-fj9l8che	227	24	North	North	NNP
cord-048466-fj9l8che	227	25	America	America	NNP
cord-048466-fj9l8che	227	26	and	and	CC
cord-048466-fj9l8che	227	27	Asia	Asia	NNP
cord-048466-fj9l8che	227	28	Emergence	Emergence	NNP
cord-048466-fj9l8che	227	29	of	of	IN
cord-048466-fj9l8che	227	30	amantadine	amantadine	NN
cord-048466-fj9l8che	227	31	-	-	HYPH
cord-048466-fj9l8che	227	32	resistant	resistant	JJ
cord-048466-fj9l8che	227	33	influenza	influenza	NN
cord-048466-fj9l8che	227	34	A	a	DT
cord-048466-fj9l8che	227	35	viruses	virus	NNS
cord-048466-fj9l8che	228	1	:	:	:
cord-048466-fj9l8che	228	2	epidemiological	epidemiological	JJ
cord-048466-fj9l8che	228	3	study	study	NN
cord-048466-fj9l8che	228	4	Influenza	Influenza	NNP
cord-048466-fj9l8che	228	5	virus	virus	NN
cord-048466-fj9l8che	229	1	neuraminidase	neuraminidase	NNP
cord-048466-fj9l8che	229	2	inhibitors	inhibitor	NNS
cord-048466-fj9l8che	230	1	The	the	DT
cord-048466-fj9l8che	230	2	H274Y	H274Y	NNP
cord-048466-fj9l8che	230	3	mutation	mutation	NN
cord-048466-fj9l8che	230	4	in	in	IN
cord-048466-fj9l8che	230	5	the	the	DT
cord-048466-fj9l8che	230	6	influenza	influenza	NN
cord-048466-fj9l8che	230	7	A	A	NNP
cord-048466-fj9l8che	230	8	/	/	SYM
cord-048466-fj9l8che	230	9	H1N1	H1N1	NNP
cord-048466-fj9l8che	230	10	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	230	11	active	active	JJ
cord-048466-fj9l8che	230	12	site	site	NN
cord-048466-fj9l8che	230	13	following	follow	VBG
cord-048466-fj9l8che	230	14	oseltamivir	oseltamivir	FW
cord-048466-fj9l8che	230	15	phosphate	phosphate	NN
cord-048466-fj9l8che	230	16	treatment	treatment	NN
cord-048466-fj9l8che	230	17	leave	leave	VBP
cord-048466-fj9l8che	230	18	virus	virus	NN
cord-048466-fj9l8che	230	19	severely	severely	RB
cord-048466-fj9l8che	230	20	compromised	compromise	VBD
cord-048466-fj9l8che	230	21	both	both	CC
cord-048466-fj9l8che	230	22	in	in	IN
cord-048466-fj9l8che	230	23	vitro	vitro	FW
cord-048466-fj9l8che	230	24	and	and	CC
cord-048466-fj9l8che	230	25	in	in	IN
cord-048466-fj9l8che	230	26	vivo	vivo	NNP
cord-048466-fj9l8che	230	27	Ab	Ab	NNP
cord-048466-fj9l8che	230	28	and	and	CC
cord-048466-fj9l8che	230	29	T	T	NNP
cord-048466-fj9l8che	230	30	cell	cell	NN
cord-048466-fj9l8che	230	31	epitopes	epitope	NNS
cord-048466-fj9l8che	230	32	of	of	IN
cord-048466-fj9l8che	230	33	influenza	influenza	NN
cord-048466-fj9l8che	230	34	A	a	DT
cord-048466-fj9l8che	230	35	virus	virus	NN
cord-048466-fj9l8che	230	36	,	,	,
cord-048466-fj9l8che	230	37	knowledge	knowledge	NN
cord-048466-fj9l8che	230	38	and	and	CC
cord-048466-fj9l8che	230	39	opportunities	opportunity	NNS
cord-048466-fj9l8che	231	1	The	the	DT
cord-048466-fj9l8che	231	2	influenza	influenza	NN
cord-048466-fj9l8che	231	3	A	a	DT
cord-048466-fj9l8che	231	4	virus	virus	NN
cord-048466-fj9l8che	231	5	nucleoprotein	nucleoprotein	NNP
cord-048466-fj9l8che	231	6	gene	gene	NN
cord-048466-fj9l8che	231	7	controls	control	VBZ
cord-048466-fj9l8che	231	8	the	the	DT
cord-048466-fj9l8che	231	9	induction	induction	NN
cord-048466-fj9l8che	231	10	of	of	IN
cord-048466-fj9l8che	231	11	both	both	DT
cord-048466-fj9l8che	231	12	subtype	subtype	NN
cord-048466-fj9l8che	231	13	specific	specific	JJ
cord-048466-fj9l8che	231	14	and	and	CC
cord-048466-fj9l8che	231	15	cross	cross	JJ
cord-048466-fj9l8che	231	16	-	-	JJ
cord-048466-fj9l8che	231	17	reactive	reactive	JJ
cord-048466-fj9l8che	231	18	cytotoxic	cytotoxic	JJ
cord-048466-fj9l8che	231	19	T	t	NN
cord-048466-fj9l8che	231	20	cells	cell	NNS
cord-048466-fj9l8che	232	1	The	the	DT
cord-048466-fj9l8che	232	2	structure	structure	NN
cord-048466-fj9l8che	232	3	of	of	IN
cord-048466-fj9l8che	232	4	the	the	DT
cord-048466-fj9l8che	232	5	gene	gene	NN
cord-048466-fj9l8che	232	6	encoding	encode	VBG
cord-048466-fj9l8che	232	7	the	the	DT
cord-048466-fj9l8che	232	8	nucleoprotein	nucleoprotein	NNP
cord-048466-fj9l8che	232	9	of	of	IN
cord-048466-fj9l8che	232	10	human	human	NNP
cord-048466-fj9l8che	232	11	influenza	influenza	NNP
cord-048466-fj9l8che	232	12	virus	virus	NN
cord-048466-fj9l8che	233	1	A	a	LS
cord-048466-fj9l8che	233	2	/	/	SYM
cord-048466-fj9l8che	233	3	PR/8/34	PR/8/34	NNP
cord-048466-fj9l8che	233	4	Generation	generation	NN
cord-048466-fj9l8che	233	5	and	and	CC
cord-048466-fj9l8che	233	6	characterization	characterization	NN
cord-048466-fj9l8che	233	7	of	of	IN
cord-048466-fj9l8che	233	8	recombinant	recombinant	JJ
cord-048466-fj9l8che	233	9	influenza	influenza	NN
cord-048466-fj9l8che	233	10	A	a	NN
cord-048466-fj9l8che	233	11	(	(	-LRB-
cord-048466-fj9l8che	233	12	H1N1	H1N1	NNP
cord-048466-fj9l8che	233	13	)	)	-RRB-
cord-048466-fj9l8che	233	14	viruses	viruse	VBZ
cord-048466-fj9l8che	233	15	harboring	harbor	VBG
cord-048466-fj9l8che	233	16	amantadine	amantadine	NN
cord-048466-fj9l8che	233	17	resistance	resistance	NN
cord-048466-fj9l8che	233	18	mutations	mutation	NNS
cord-048466-fj9l8che	233	19	Adamantane	Adamantane	NNP
cord-048466-fj9l8che	233	20	Reasistance	Reasistance	NNP
cord-048466-fj9l8che	234	1	Among	among	IN
cord-048466-fj9l8che	234	2	Influenza	Influenza	NNP
cord-048466-fj9l8che	234	3	A	A	NNP
cord-048466-fj9l8che	234	4	Viruses	virus	NNS
cord-048466-fj9l8che	234	5	Isolated	isolate	VBN
cord-048466-fj9l8che	235	1	Early	early	RB
cord-048466-fj9l8che	235	2	During	during	IN
cord-048466-fj9l8che	235	3	the	the	DT
cord-048466-fj9l8che	235	4	2005	2005	CD
cord-048466-fj9l8che	235	5	-	-	SYM
cord-048466-fj9l8che	235	6	2006	2006	CD
cord-048466-fj9l8che	235	7	Influenza	Influenza	NNP
cord-048466-fj9l8che	235	8	Season	Season	NNP
cord-048466-fj9l8che	235	9	in	in	IN
cord-048466-fj9l8che	235	10	the	the	DT
cord-048466-fj9l8che	235	11	United	United	NNP
cord-048466-fj9l8che	235	12	States	States	NNP
cord-048466-fj9l8che	235	13	Increased	increase	VBN
cord-048466-fj9l8che	235	14	adamantane	adamantane	NN
cord-048466-fj9l8che	235	15	resistance	resistance	NN
cord-048466-fj9l8che	235	16	in	in	IN
cord-048466-fj9l8che	235	17	influenza	influenza	NN
cord-048466-fj9l8che	235	18	A(H3	a(h3	CD
cord-048466-fj9l8che	235	19	)	)	-RRB-
cord-048466-fj9l8che	236	1	viruses	virus	NNS
cord-048466-fj9l8che	236	2	in	in	IN
cord-048466-fj9l8che	236	3	Australia	Australia	NNP
cord-048466-fj9l8che	236	4	and	and	CC
cord-048466-fj9l8che	236	5	neighbouring	neighbouring	NN
cord-048466-fj9l8che	236	6	countries	country	NNS
cord-048466-fj9l8che	236	7	in	in	IN
cord-048466-fj9l8che	236	8	2005	2005	CD
cord-048466-fj9l8che	237	1	Hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	237	2	Residues	residue	NNS
cord-048466-fj9l8che	237	3	of	of	IN
cord-048466-fj9l8che	237	4	Recent	Recent	NNP
cord-048466-fj9l8che	237	5	Human	Human	NNP
cord-048466-fj9l8che	237	6	A(H3N2	A(H3N2	NNP
cord-048466-fj9l8che	237	7	)	)	-RRB-
cord-048466-fj9l8che	238	1	Influenza	influenza	NN
cord-048466-fj9l8che	238	2	Viruses	virus	NNS
cord-048466-fj9l8che	239	1	That	that	DT
cord-048466-fj9l8che	239	2	Contribute	contribute	VB
cord-048466-fj9l8che	239	3	to	to	IN
cord-048466-fj9l8che	239	4	the	the	DT
cord-048466-fj9l8che	239	5	Inability	Inability	NNP
cord-048466-fj9l8che	239	6	to	to	TO
cord-048466-fj9l8che	239	7	Agglutinate	agglutinate	VB
cord-048466-fj9l8che	239	8	Chicken	Chicken	NNP
cord-048466-fj9l8che	239	9	Erythrocytes	Erythrocytes	NNP
cord-048466-fj9l8che	239	10	Receptor	Receptor	NNP
cord-048466-fj9l8che	239	11	-	-	HYPH
cord-048466-fj9l8che	239	12	binding	bind	VBG
cord-048466-fj9l8che	239	13	properties	property	NNS
cord-048466-fj9l8che	239	14	of	of	IN
cord-048466-fj9l8che	239	15	modern	modern	JJ
cord-048466-fj9l8che	239	16	human	human	JJ
cord-048466-fj9l8che	239	17	influenza	influenza	NN
cord-048466-fj9l8che	239	18	viruses	virus	NNS
cord-048466-fj9l8che	239	19	primarily	primarily	RB
cord-048466-fj9l8che	239	20	isolated	isolate	VBN
cord-048466-fj9l8che	239	21	in	in	IN
cord-048466-fj9l8che	239	22	Vero	Vero	NNP
cord-048466-fj9l8che	239	23	and	and	CC
cord-048466-fj9l8che	239	24	MDCK	MDCK	NNP
cord-048466-fj9l8che	239	25	cells	cell	NNS
cord-048466-fj9l8che	239	26	and	and	CC
cord-048466-fj9l8che	239	27	chicken	chicken	NN
cord-048466-fj9l8che	239	28	embryonated	embryonate	VBN
cord-048466-fj9l8che	239	29	eggs	egg	NNS
cord-048466-fj9l8che	239	30	Improvement	Improvement	NNP
cord-048466-fj9l8che	239	31	of	of	IN
cord-048466-fj9l8che	239	32	Influenza	Influenza	NNP
cord-048466-fj9l8che	239	33	A	A	NNP
cord-048466-fj9l8che	239	34	/	/	SYM
cord-048466-fj9l8che	239	35	Fujian/411/02	Fujian/411/02	NNP
cord-048466-fj9l8che	239	36	(	(	-LRB-
cord-048466-fj9l8che	239	37	H3N2	H3N2	NNP
cord-048466-fj9l8che	239	38	)	)	-RRB-
cord-048466-fj9l8che	239	39	Virus	virus	NN
cord-048466-fj9l8che	239	40	Growth	Growth	NNP
cord-048466-fj9l8che	239	41	in	in	IN
cord-048466-fj9l8che	239	42	Embryonated	Embryonated	NNP
cord-048466-fj9l8che	239	43	Chicken	Chicken	NNP
cord-048466-fj9l8che	239	44	Eggs	Eggs	NNP
cord-048466-fj9l8che	239	45	by	by	IN
cord-048466-fj9l8che	239	46	Balancing	balance	VBG
cord-048466-fj9l8che	239	47	the	the	DT
cord-048466-fj9l8che	239	48	Hemagglutinin	Hemagglutinin	NNP
cord-048466-fj9l8che	239	49	and	and	CC
cord-048466-fj9l8che	239	50	Neuraminidase	Neuraminidase	NNP
cord-048466-fj9l8che	239	51	Activities	Activities	NNPS
cord-048466-fj9l8che	239	52	,	,	,
cord-048466-fj9l8che	239	53	Using	use	VBG
cord-048466-fj9l8che	239	54	Reverse	Reverse	NNP
cord-048466-fj9l8che	239	55	Genetics	Genetics	NNP
cord-048466-fj9l8che	239	56	Single	single	JJ
cord-048466-fj9l8che	239	57	amino	amino	NN
cord-048466-fj9l8che	239	58	acid	acid	NN
cord-048466-fj9l8che	239	59	substitutions	substitution	NNS
cord-048466-fj9l8che	239	60	in	in	IN
cord-048466-fj9l8che	239	61	the	the	DT
cord-048466-fj9l8che	239	62	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	239	63	of	of	IN
cord-048466-fj9l8che	239	64	influenza	influenza	NN
cord-048466-fj9l8che	239	65	A	A	NNP
cord-048466-fj9l8che	239	66	/	/	,
cord-048466-fj9l8che	239	67	Singapore/21/	singapore/21/	NN
cord-048466-fj9l8che	239	68	04	04	CD
cord-048466-fj9l8che	239	69	(	(	-LRB-
cord-048466-fj9l8che	239	70	H3N2	H3N2	NNP
cord-048466-fj9l8che	239	71	)	)	-RRB-
cord-048466-fj9l8che	239	72	increase	increase	VB
cord-048466-fj9l8che	239	73	virus	virus	NN
cord-048466-fj9l8che	239	74	growth	growth	NN
cord-048466-fj9l8che	239	75	in	in	IN
cord-048466-fj9l8che	239	76	embryonated	embryonate	VBN
cord-048466-fj9l8che	239	77	chicken	chicken	NN
cord-048466-fj9l8che	239	78	eggs	egg	NNS
cord-048466-fj9l8che	239	79	Effect	Effect	NNP
cord-048466-fj9l8che	239	80	of	of	IN
cord-048466-fj9l8che	239	81	the	the	DT
cord-048466-fj9l8che	239	82	addition	addition	NN
cord-048466-fj9l8che	239	83	of	of	IN
cord-048466-fj9l8che	239	84	oligosaccharides	oligosaccharide	NNS
cord-048466-fj9l8che	239	85	on	on	IN
cord-048466-fj9l8che	239	86	the	the	DT
cord-048466-fj9l8che	239	87	biological	biological	JJ
cord-048466-fj9l8che	239	88	activities	activity	NNS
cord-048466-fj9l8che	239	89	and	and	CC
cord-048466-fj9l8che	239	90	antigenicity	antigenicity	NN
cord-048466-fj9l8che	239	91	of	of	IN
cord-048466-fj9l8che	239	92	influenza	influenza	NN
cord-048466-fj9l8che	239	93	A	a	NN
cord-048466-fj9l8che	239	94	/	/	SYM
cord-048466-fj9l8che	239	95	H3N2	H3N2	NNP
cord-048466-fj9l8che	239	96	virus	virus	NN
cord-048466-fj9l8che	239	97	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	239	98	Variation	variation	NN
cord-048466-fj9l8che	239	99	and	and	CC
cord-048466-fj9l8che	239	100	infectivity	infectivity	NN
cord-048466-fj9l8che	239	101	neutralization	neutralization	NN
cord-048466-fj9l8che	239	102	in	in	IN
cord-048466-fj9l8che	239	103	influenza	influenza	JJ
cord-048466-fj9l8che	239	104	Genetic	genetic	JJ
cord-048466-fj9l8che	239	105	variation	variation	NN
cord-048466-fj9l8che	239	106	in	in	IN
cord-048466-fj9l8che	239	107	neuraminidase	neuraminidase	JJ
cord-048466-fj9l8che	239	108	genes	gene	NNS
cord-048466-fj9l8che	239	109	of	of	IN
cord-048466-fj9l8che	239	110	influenza	influenza	NN
cord-048466-fj9l8che	239	111	A	a	NN
cord-048466-fj9l8che	239	112	(	(	-LRB-
cord-048466-fj9l8che	239	113	H3N2	H3N2	NNP
cord-048466-fj9l8che	239	114	)	)	-RRB-
cord-048466-fj9l8che	239	115	viruses	viruse	VBZ
cord-048466-fj9l8che	239	116	Long	long	JJ
cord-048466-fj9l8che	239	117	intervals	interval	NNS
cord-048466-fj9l8che	239	118	of	of	IN
cord-048466-fj9l8che	239	119	stasis	stasis	NN
cord-048466-fj9l8che	239	120	punctuated	punctuate	VBN
cord-048466-fj9l8che	239	121	by	by	IN
cord-048466-fj9l8che	239	122	bursts	burst	NNS
cord-048466-fj9l8che	239	123	of	of	IN
cord-048466-fj9l8che	239	124	positive	positive	JJ
cord-048466-fj9l8che	239	125	selection	selection	NN
cord-048466-fj9l8che	239	126	in	in	IN
cord-048466-fj9l8che	239	127	the	the	DT
cord-048466-fj9l8che	239	128	seasonal	seasonal	JJ
cord-048466-fj9l8che	239	129	evolution	evolution	NN
cord-048466-fj9l8che	239	130	of	of	IN
cord-048466-fj9l8che	239	131	influenza	influenza	NN
cord-048466-fj9l8che	239	132	A	a	DT
cord-048466-fj9l8che	239	133	virus	virus	NN
cord-048466-fj9l8che	239	134	Stochastic	Stochastic	NNP
cord-048466-fj9l8che	239	135	Processes	process	NNS
cord-048466-fj9l8che	239	136	Are	be	VBP
cord-048466-fj9l8che	239	137	Key	key	JJ
cord-048466-fj9l8che	239	138	Determinants	determinant	NNS
cord-048466-fj9l8che	239	139	of	of	IN
cord-048466-fj9l8che	239	140	Short	Short	NNP
cord-048466-fj9l8che	239	141	-	-	HYPH
cord-048466-fj9l8che	239	142	Term	Term	NNP
cord-048466-fj9l8che	239	143	Evolution	Evolution	NNP
cord-048466-fj9l8che	239	144	in	in	IN
cord-048466-fj9l8che	239	145	Influenza	Influenza	NNP
cord-048466-fj9l8che	239	146	A	A	NNP
cord-048466-fj9l8che	239	147	Virus	virus	NN
cord-048466-fj9l8che	239	148	Positive	positive	JJ
cord-048466-fj9l8che	239	149	selection	selection	NN
cord-048466-fj9l8che	239	150	on	on	IN
cord-048466-fj9l8che	239	151	the	the	DT
cord-048466-fj9l8che	239	152	H3	H3	NNP
cord-048466-fj9l8che	239	153	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	239	154	gene	gene	NN
cord-048466-fj9l8che	239	155	of	of	IN
cord-048466-fj9l8che	239	156	human	human	JJ
cord-048466-fj9l8che	239	157	influenza	influenza	NN
cord-048466-fj9l8che	239	158	virus	virus	NN
cord-048466-fj9l8che	239	159	A	a	DT
cord-048466-fj9l8che	239	160	Genome	Genome	NNP
cord-048466-fj9l8che	239	161	characterisation	characterisation	NN
cord-048466-fj9l8che	239	162	of	of	IN
cord-048466-fj9l8che	239	163	the	the	DT
cord-048466-fj9l8che	239	164	newly	newly	RB
cord-048466-fj9l8che	239	165	discovered	discover	VBN
cord-048466-fj9l8che	239	166	avian	avian	JJ
cord-048466-fj9l8che	239	167	influenza	influenza	NN
cord-048466-fj9l8che	239	168	A	a	DT
cord-048466-fj9l8che	239	169	H5N7	H5N7	NNP
cord-048466-fj9l8che	239	170	virus	virus	NN
cord-048466-fj9l8che	239	171	subtype	subtype	NN
cord-048466-fj9l8che	239	172	combination	combination	NN
cord-048466-fj9l8che	239	173	Universal	Universal	NNP
cord-048466-fj9l8che	239	174	primer	primer	NN
cord-048466-fj9l8che	239	175	set	set	VBN
cord-048466-fj9l8che	239	176	for	for	IN
cord-048466-fj9l8che	239	177	the	the	DT
cord-048466-fj9l8che	239	178	full	full	JJ
cord-048466-fj9l8che	239	179	-	-	HYPH
cord-048466-fj9l8che	239	180	length	length	NN
cord-048466-fj9l8che	239	181	amplification	amplification	NN
cord-048466-fj9l8che	239	182	of	of	IN
cord-048466-fj9l8che	239	183	all	all	DT
cord-048466-fj9l8che	239	184	influenza	influenza	NN
cord-048466-fj9l8che	239	185	A	a	NN
cord-048466-fj9l8che	239	186	viruses	virus	NNS
cord-048466-fj9l8che	239	187	New	new	JJ
cord-048466-fj9l8che	239	188	avian	avian	JJ
cord-048466-fj9l8che	239	189	influenza	influenza	NN
cord-048466-fj9l8che	239	190	A	a	DT
cord-048466-fj9l8che	239	191	virus	virus	NN
cord-048466-fj9l8che	239	192	subtype	subtype	NN
cord-048466-fj9l8che	239	193	combination	combination	NN
cord-048466-fj9l8che	239	194	H5N7	H5N7	NNP
cord-048466-fj9l8che	239	195	identified	identify	VBN
cord-048466-fj9l8che	239	196	in	in	IN
cord-048466-fj9l8che	239	197	Danish	danish	JJ
cord-048466-fj9l8che	239	198	mallard	mallard	NN
cord-048466-fj9l8che	239	199	ducks	duck	NNS
cord-048466-fj9l8che	239	200	BioEdit	BioEdit	NNP
cord-048466-fj9l8che	239	201	:	:	:
cord-048466-fj9l8che	239	202	a	a	DT
cord-048466-fj9l8che	239	203	user	user	NN
cord-048466-fj9l8che	239	204	-	-	HYPH
cord-048466-fj9l8che	239	205	friendly	friendly	JJ
cord-048466-fj9l8che	239	206	biological	biological	JJ
cord-048466-fj9l8che	239	207	sequence	sequence	NN
cord-048466-fj9l8che	239	208	alignment	alignment	NN
cord-048466-fj9l8che	239	209	editor	editor	NN
cord-048466-fj9l8che	239	210	and	and	CC
cord-048466-fj9l8che	239	211	analysis	analysis	NN
cord-048466-fj9l8che	239	212	program	program	NN
cord-048466-fj9l8che	239	213	for	for	IN
cord-048466-fj9l8che	239	214	Windows	Windows	NNP
cord-048466-fj9l8che	239	215	95/98	95/98	CD
cord-048466-fj9l8che	239	216	/	/	SYM
cord-048466-fj9l8che	239	217	NT	NT	NNP
cord-048466-fj9l8che	239	218	Integrated	Integrated	NNP
cord-048466-fj9l8che	239	219	Software	Software	NNP
cord-048466-fj9l8che	239	220	for	for	IN
cord-048466-fj9l8che	239	221	Molecular	Molecular	NNP
cord-048466-fj9l8che	239	222	Evolutionary	Evolutionary	NNP
cord-048466-fj9l8che	239	223	Genetics	Genetics	NNP
cord-048466-fj9l8che	239	224	Analysis	Analysis	NNP
cord-048466-fj9l8che	239	225	and	and	CC
cord-048466-fj9l8che	239	226	Sequence	Sequence	NNP
cord-048466-fj9l8che	239	227	Alignment	Alignment	NNP
cord-048466-fj9l8che	239	228	Phylogenetic	Phylogenetic	NNP
cord-048466-fj9l8che	239	229	Analysis	Analysis	NNP
cord-048466-fj9l8che	240	1	Using	use	VBG
cord-048466-fj9l8che	240	2	Parsimony	Parsimony	NNP
cord-048466-fj9l8che	240	3	Datamonkey	Datamonkey	NNP
cord-048466-fj9l8che	240	4	:	:	:
cord-048466-fj9l8che	240	5	rapid	rapid	JJ
cord-048466-fj9l8che	240	6	detection	detection	NN
cord-048466-fj9l8che	240	7	of	of	IN
cord-048466-fj9l8che	240	8	selective	selective	JJ
cord-048466-fj9l8che	240	9	pressure	pressure	NN
cord-048466-fj9l8che	240	10	on	on	IN
cord-048466-fj9l8che	240	11	individual	individual	JJ
cord-048466-fj9l8che	240	12	sites	site	NNS
cord-048466-fj9l8che	240	13	of	of	IN
cord-048466-fj9l8che	240	14	codon	codon	NN
cord-048466-fj9l8che	240	15	alignments	alignment	NNS
cord-048466-fj9l8che	241	1	A	a	DT
cord-048466-fj9l8che	241	2	method	method	NN
cord-048466-fj9l8che	241	3	for	for	IN
cord-048466-fj9l8che	241	4	detecting	detect	VBG
cord-048466-fj9l8che	241	5	positive	positive	JJ
cord-048466-fj9l8che	241	6	selection	selection	NN
cord-048466-fj9l8che	241	7	at	at	IN
cord-048466-fj9l8che	241	8	single	single	JJ
cord-048466-fj9l8che	241	9	amino	amino	NN
cord-048466-fj9l8che	241	10	acid	acid	NN
cord-048466-fj9l8che	241	11	sites	site	NNS
cord-048466-fj9l8che	241	12	HyPhy	HyPhy	NNP
cord-048466-fj9l8che	241	13	:	:	:
cord-048466-fj9l8che	241	14	hypothesis	hypothesis	NN
cord-048466-fj9l8che	241	15	testing	testing	NN
cord-048466-fj9l8che	241	16	using	use	VBG
cord-048466-fj9l8che	241	17	phylogenies	phylogeny	NNS
cord-048466-fj9l8che	242	1	Not	not	RB
cord-048466-fj9l8che	242	2	So	so	RB
cord-048466-fj9l8che	242	3	Different	different	JJ
cord-048466-fj9l8che	242	4	After	after	IN
cord-048466-fj9l8che	242	5	All	all	RB
cord-048466-fj9l8che	242	6	:	:	:
cord-048466-fj9l8che	243	1	A	a	DT
cord-048466-fj9l8che	243	2	Comparison	comparison	NN
cord-048466-fj9l8che	243	3	of	of	IN
cord-048466-fj9l8che	243	4	Methods	method	NNS
cord-048466-fj9l8che	243	5	for	for	IN
cord-048466-fj9l8che	243	6	Detecting	detect	VBG
cord-048466-fj9l8che	243	7	Amino	amino	NN
cord-048466-fj9l8che	243	8	Acid	acid	NN
cord-048466-fj9l8che	243	9	Sites	site	NNS
cord-048466-fj9l8che	243	10	Under	under	IN
cord-048466-fj9l8che	243	11	Selection	Selection	NNP
cord-048466-fj9l8che	243	12	Prediction	Prediction	NNP
cord-048466-fj9l8che	243	13	of	of	IN
cord-048466-fj9l8che	243	14	N	n	CD
cord-048466-fj9l8che	243	15	-	-	HYPH
cord-048466-fj9l8che	243	16	glycosylation	glycosylation	NN
cord-048466-fj9l8che	243	17	sites	site	NNS
cord-048466-fj9l8che	243	18	in	in	IN
cord-048466-fj9l8che	243	19	human	human	JJ
cord-048466-fj9l8che	243	20	proteins	protein	NNS
cord-048466-fj9l8che	244	1	Tracking	track	VBG
cord-048466-fj9l8che	244	2	global	global	JJ
cord-048466-fj9l8che	244	3	patterns	pattern	NNS
cord-048466-fj9l8che	244	4	of	of	IN
cord-048466-fj9l8che	244	5	N	n	CD
cord-048466-fj9l8che	244	6	-	-	HYPH
cord-048466-fj9l8che	244	7	linked	link	VBN
cord-048466-fj9l8che	244	8	glycosylation	glycosylation	NN
cord-048466-fj9l8che	244	9	site	site	NN
cord-048466-fj9l8che	244	10	variation	variation	NN
cord-048466-fj9l8che	244	11	in	in	IN
cord-048466-fj9l8che	244	12	highly	highly	RB
cord-048466-fj9l8che	244	13	variable	variable	JJ
cord-048466-fj9l8che	244	14	viral	viral	JJ
cord-048466-fj9l8che	244	15	glycoproteins	glycoprotein	NNS
cord-048466-fj9l8che	244	16	:	:	:
cord-048466-fj9l8che	244	17	HIV	HIV	NNP
cord-048466-fj9l8che	244	18	,	,	,
cord-048466-fj9l8che	244	19	SIV	SIV	NNP
cord-048466-fj9l8che	244	20	,	,	,
cord-048466-fj9l8che	244	21	and	and	CC
cord-048466-fj9l8che	244	22	HCV	HCV	NNP
cord-048466-fj9l8che	244	23	envelopes	envelope	NNS
cord-048466-fj9l8che	244	24	and	and	CC
cord-048466-fj9l8che	244	25	influenza	influenza	NN
cord-048466-fj9l8che	244	26	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	244	27	Quantifying	quantify	VBG
cord-048466-fj9l8che	244	28	influenza	influenza	JJ
cord-048466-fj9l8che	244	29	vaccine	vaccine	NN
cord-048466-fj9l8che	244	30	efficacy	efficacy	NN
cord-048466-fj9l8che	244	31	and	and	CC
cord-048466-fj9l8che	244	32	antigenic	antigenic	JJ
cord-048466-fj9l8che	244	33	distance	distance	NN
cord-048466-fj9l8che	244	34	Calculation	Calculation	NNP
cord-048466-fj9l8che	244	35	of	of	IN
cord-048466-fj9l8che	244	36	Pepitope	Pepitope	NNP
cord-048466-fj9l8che	244	37	using	use	VBG
cord-048466-fj9l8che	244	38	Microsoft	Microsoft	NNP
cord-048466-fj9l8che	244	39	Excel	Excel	NNP
cord-048466-fj9l8che	244	40	Location	Location	NNP
cord-048466-fj9l8che	244	41	of	of	IN
cord-048466-fj9l8che	244	42	antigenic	antigenic	JJ
cord-048466-fj9l8che	244	43	sites	site	NNS
cord-048466-fj9l8che	244	44	on	on	IN
cord-048466-fj9l8che	244	45	the	the	DT
cord-048466-fj9l8che	244	46	three	three	CD
cord-048466-fj9l8che	244	47	-	-	HYPH
cord-048466-fj9l8che	244	48	dimensional	dimensional	JJ
cord-048466-fj9l8che	244	49	structure	structure	NN
cord-048466-fj9l8che	244	50	of	of	IN
cord-048466-fj9l8che	244	51	the	the	DT
cord-048466-fj9l8che	244	52	influenza	influenza	NN
cord-048466-fj9l8che	244	53	N2	N2	NNP
cord-048466-fj9l8che	244	54	virus	virus	NN
cord-048466-fj9l8che	244	55	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	245	1	The	the	DT
cord-048466-fj9l8che	245	2	antigenic	antigenic	JJ
cord-048466-fj9l8che	245	3	structure	structure	NN
cord-048466-fj9l8che	245	4	of	of	IN
cord-048466-fj9l8che	245	5	the	the	DT
cord-048466-fj9l8che	245	6	influenza	influenza	NN
cord-048466-fj9l8che	245	7	virus	virus	NN
cord-048466-fj9l8che	245	8	A/	A/	NNP
cord-048466-fj9l8che	246	1	PR/8/34	pr/8/34	IN
cord-048466-fj9l8che	246	2	hemagglutinin	hemagglutinin	NNS
cord-048466-fj9l8che	246	3	(	(	-LRB-
cord-048466-fj9l8che	246	4	H1	H1	NNP
cord-048466-fj9l8che	246	5	subtype	subtype	NN
cord-048466-fj9l8che	246	6	)	)	-RRB-
cord-048466-fj9l8che	246	7	Structure	structure	NN
cord-048466-fj9l8che	246	8	of	of	IN
cord-048466-fj9l8che	246	9	the	the	DT
cord-048466-fj9l8che	246	10	catalytic	catalytic	JJ
cord-048466-fj9l8che	246	11	and	and	CC
cord-048466-fj9l8che	246	12	antigenic	antigenic	JJ
cord-048466-fj9l8che	246	13	sites	site	NNS
cord-048466-fj9l8che	246	14	in	in	IN
cord-048466-fj9l8che	246	15	influenza	influenza	NN
cord-048466-fj9l8che	246	16	virus	virus	NN
cord-048466-fj9l8che	246	17	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	246	18	Phylogenetically	phylogenetically	RB
cord-048466-fj9l8che	246	19	important	important	JJ
cord-048466-fj9l8che	246	20	regions	region	NNS
cord-048466-fj9l8che	246	21	of	of	IN
cord-048466-fj9l8che	246	22	the	the	DT
cord-048466-fj9l8che	246	23	Influenza	Influenza	NNP
cord-048466-fj9l8che	246	24	A	a	DT
cord-048466-fj9l8che	246	25	H1	H1	NNP
cord-048466-fj9l8che	246	26	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	246	27	protein	protein	NN
cord-048466-fj9l8che	247	1	The	the	DT
cord-048466-fj9l8che	247	2	structure	structure	NN
cord-048466-fj9l8che	247	3	and	and	CC
cord-048466-fj9l8che	247	4	function	function	NN
cord-048466-fj9l8che	247	5	of	of	IN
cord-048466-fj9l8che	247	6	the	the	DT
cord-048466-fj9l8che	247	7	hemagglutinin	hemagglutinin	NN
cord-048466-fj9l8che	247	8	membrane	membrane	NN
cord-048466-fj9l8che	247	9	glycoprotein	glycoprotein	NN
cord-048466-fj9l8che	247	10	of	of	IN
cord-048466-fj9l8che	247	11	influenza	influenza	NN
cord-048466-fj9l8che	247	12	virus	virus	NN
cord-048466-fj9l8che	247	13	Influenza	Influenza	NNP
cord-048466-fj9l8che	247	14	virus	virus	NN
cord-048466-fj9l8che	247	15	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	247	16	:	:	:
cord-048466-fj9l8che	248	1	Structure	structure	NN
cord-048466-fj9l8che	248	2	,	,	,
cord-048466-fj9l8che	248	3	antibodies	antibody	NNS
cord-048466-fj9l8che	248	4	,	,	,
cord-048466-fj9l8che	248	5	and	and	CC
cord-048466-fj9l8che	248	6	inhibitors	inhibitor	NNS
cord-048466-fj9l8che	249	1	The	the	DT
cord-048466-fj9l8che	249	2	neuraminidase	neuraminidase	NN
cord-048466-fj9l8che	249	3	of	of	IN
cord-048466-fj9l8che	249	4	influenza	influenza	NN
cord-048466-fj9l8che	249	5	virus	virus	NN
cord-048466-fj9l8che	249	6	.	.	.
cord-048466-fj9l8che	250	1	Proteins	protein	NNS
cord-048466-fj9l8che	250	2	1989	1989	CD
cord-048466-fj9l8che	251	1	We	-PRON-	PRP
cord-048466-fj9l8che	251	2	thank	thank	VBP
cord-048466-fj9l8che	251	3	Bente	Bente	NNP
cord-048466-fj9l8che	251	4	Østergaard	Østergaard	NNP
cord-048466-fj9l8che	251	5	,	,	,
cord-048466-fj9l8che	251	6	Christine	Christine	NNP
cord-048466-fj9l8che	251	7	Valdez	Valdez	NNP
cord-048466-fj9l8che	251	8	and	and	CC
cord-048466-fj9l8che	251	9	Bente	Bente	NNP
cord-048466-fj9l8che	251	10	Andersen	Andersen	NNP
cord-048466-fj9l8che	251	11	for	for	IN
cord-048466-fj9l8che	251	12	their	-PRON-	PRP$
cord-048466-fj9l8che	251	13	excellent	excellent	JJ
cord-048466-fj9l8che	251	14	laboratory	laboratory	NN
cord-048466-fj9l8che	251	15	work	work	NN
cord-048466-fj9l8che	251	16	and	and	CC
cord-048466-fj9l8che	251	17	Sofie	Sofie	NNP
cord-048466-fj9l8che	251	18	E.	E.	NNP
cord-048466-fj9l8che	251	19	Midgley	Midgley	NNP
cord-048466-fj9l8che	251	20	for	for	IN
cord-048466-fj9l8che	251	21	kindly	kindly	RB
cord-048466-fj9l8che	251	22	proof	proof	NN
cord-048466-fj9l8che	251	23	reading	read	VBG
cord-048466-fj9l8che	251	24	the	the	DT
cord-048466-fj9l8che	251	25	manuscript	manuscript	NN
cord-048466-fj9l8che	251	26	.	.	.
cord-048466-fj9l8che	252	1	The	the	DT
cord-048466-fj9l8che	252	2	author(s	author(s	NNP
cord-048466-fj9l8che	252	3	)	)	-RRB-
cord-048466-fj9l8che	252	4	declare	declare	VBP
cord-048466-fj9l8che	252	5	that	that	IN
cord-048466-fj9l8che	252	6	they	-PRON-	PRP
cord-048466-fj9l8che	252	7	have	have	VBP
cord-048466-fj9l8che	252	8	no	no	DT
cord-048466-fj9l8che	252	9	competing	compete	VBG
cord-048466-fj9l8che	252	10	interests	interest	NNS
cord-048466-fj9l8che	252	11	.	.	.
cord-048466-fj9l8che	253	1	KB	KB	NNP
cord-048466-fj9l8che	253	2	conceived	conceive	VBD
cord-048466-fj9l8che	253	3	and	and	CC
cord-048466-fj9l8che	253	4	designed	design	VBD
cord-048466-fj9l8che	253	5	the	the	DT
cord-048466-fj9l8che	253	6	experiments	experiment	NNS
cord-048466-fj9l8che	253	7	.	.	.
cord-048466-fj9l8che	254	1	KB	KB	NNP
cord-048466-fj9l8che	254	2	performed	perform	VBD
cord-048466-fj9l8che	254	3	the	the	DT
cord-048466-fj9l8che	254	4	experiments	experiment	NNS
cord-048466-fj9l8che	254	5	,	,	,
cord-048466-fj9l8che	254	6	data	datum	NNS
cord-048466-fj9l8che	254	7	analysis	analysis	NN
cord-048466-fj9l8che	254	8	and	and	CC
cord-048466-fj9l8che	254	9	wrote	write	VBD
cord-048466-fj9l8che	254	10	the	the	DT
cord-048466-fj9l8che	254	11	paper	paper	NN
cord-048466-fj9l8che	254	12	.	.	.
cord-048466-fj9l8che	255	1	LPN	LPN	NNP
cord-048466-fj9l8che	255	2	and	and	CC
cord-048466-fj9l8che	255	3	AF	AF	NNP
cord-048466-fj9l8che	255	4	contributed	contribute	VBD
cord-048466-fj9l8che	255	5	reagents	reagent	NNS
cord-048466-fj9l8che	255	6	and	and	CC
cord-048466-fj9l8che	255	7	materials	material	NNS
cord-048466-fj9l8che	255	8	.	.	.
cord-048466-fj9l8che	256	1	AFO	AFO	NNP
cord-048466-fj9l8che	256	2	supervised	supervise	VBD
cord-048466-fj9l8che	256	3	the	the	DT
cord-048466-fj9l8che	256	4	research	research	NN
cord-048466-fj9l8che	256	5	.	.	.
cord-048466-fj9l8che	257	1	Further	further	JJ
cord-048466-fj9l8che	257	2	LPN	LPN	NNP
cord-048466-fj9l8che	257	3	and	and	CC
cord-048466-fj9l8che	257	4	AF	AF	NNP
cord-048466-fj9l8che	257	5	critically	critically	RB
cord-048466-fj9l8che	257	6	revised	revise	VBD
cord-048466-fj9l8che	257	7	the	the	DT
cord-048466-fj9l8che	257	8	manuscript	manuscript	NN
cord-048466-fj9l8che	257	9	and	and	CC
cord-048466-fj9l8che	257	10	AF	AF	NNP
cord-048466-fj9l8che	257	11	gave	give	VBD
cord-048466-fj9l8che	257	12	the	the	DT
cord-048466-fj9l8che	257	13	final	final	JJ
cord-048466-fj9l8che	257	14	approval	approval	NN
cord-048466-fj9l8che	257	15	for	for	IN
cord-048466-fj9l8che	257	16	publication	publication	NN
cord-048466-fj9l8che	257	17	.	.	.
cord-048466-fj9l8che	258	1	All	all	DT
cord-048466-fj9l8che	258	2	authors	author	NNS
cord-048466-fj9l8che	258	3	read	read	VBP
cord-048466-fj9l8che	258	4	and	and	CC
cord-048466-fj9l8che	258	5	approved	approve	VBD
cord-048466-fj9l8che	258	6	the	the	DT
cord-048466-fj9l8che	258	7	final	final	JJ
cord-048466-fj9l8che	258	8	manuscript	manuscript	NN
cord-048466-fj9l8che	258	9	.	.	.
cord-048466-fj9l8che	259	1	Publish	publish	VB
cord-048466-fj9l8che	259	2	with	with	IN
cord-048466-fj9l8che	259	3	Bio	Bio	NNP
cord-048466-fj9l8che	259	4	Med	Med	NNP
cord-048466-fj9l8che	259	5	Central	Central	NNP
cord-048466-fj9l8che	259	6	and	and	CC
cord-048466-fj9l8che	259	7	every	every	DT
cord-048466-fj9l8che	259	8	scientist	scientist	NN
cord-048466-fj9l8che	259	9	can	can	MD
cord-048466-fj9l8che	259	10	read	read	VB
cord-048466-fj9l8che	259	11	your	-PRON-	PRP$
cord-048466-fj9l8che	259	12	work	work	NN
cord-048466-fj9l8che	259	13	free	free	JJ
cord-048466-fj9l8che	259	14	of	of	IN
cord-048466-fj9l8che	259	15	charge	charge	NN
cord-048466-fj9l8che	259	16	 	 	_SP