id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349683-3qdnnwvd	Zhang, Xuefeng	Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates	2018-07-24		.txt	text/plain	4642	230	48	The levels of anti-Ad antibodies in the Ad5-null control group (Ad empty vector, 10 11 VP/animal) were higher than those detected for the animals that received the same-dose (high-dose 10 11 VP/ animal) of Ad-HBV group, which may have resulted from gene inserting of truncated Pol, Core and Env antigen. The neutralization activity of the highest-titers serum samples from every animal in the Ad5-null control group and the three Ad-HBV groups (low, mid, and high doses) were then measured by the Ad vector luciferase-expressing inhibition assay. As shown in Table 3 and Fig. 5 , administration with Ad-HBV significantly improved the IFN-γ and IL-2 expression levels of the livers in the mid-dose, high-dose, and Ad-null control group (p < 0.05), but not in the low-dose group.	./cache/cord-349683-3qdnnwvd.txt	./txt/cord-349683-3qdnnwvd.txt