id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338372-xsg0j92t	Sainz, Bruno	Permissiveness of human hepatoma cell lines for HCV infection	2012-01-24		.txt	text/plain	9047	398	48	While varying luciferase activity after parallel HCVpp inoculation is a phenotype we have seen among Huh7 cell lines from different laboratories (Additional file 1: Figure S3 and [34] ), to functionally test whether these cells express suboptimal levels of any of the known HCV entry factors, we transiently transfected PLC, Hep3B and HepG2-CD81 cells with vectors expressing the four known human HCV receptors and reassessed their permissiveness for HCVpp and HCVcc infection 48 h post-transfection. Notably, we have previously shown that IFN-mediated activation of the innate cellular interferon response inhibits HCV RNA replication and subsequent production of de novo HCV virions ( [45] and data not shown), thus the reduced steady-state HCVcc infection levels observed in Hep3B and HepG2-CD81 cells and the decline of HCV infection observed in PLC cells, despite these cells exhibiting comparable infection initiation permissiveness, may be at least in part a consequence of HCV-induced innate immune signaling in these hepatoma cell lines.	./cache/cord-338372-xsg0j92t.txt	./txt/cord-338372-xsg0j92t.txt