id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333349-tsfxpaj6	Chai, Weidong	Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection	2014-08-08		.txt	text/plain	2524	141	51	title: Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection The purpose of this study was to determine the influence of dietary zinc oxide supplementation on vaccination and challenge infection with PRRSV. CONCLUSIONS: Our results suggest that higher levels of dietary ZnO do not have the potential to stimulate or modulate systemic immune responses after vaccination and heterologous PRRSV infection to an extent that could improve the clinical and virological outcome. In contrast to Vanhee et al., we chose a single-vaccination approach and challenge-infected the animals with a heterologous type I PRRSV (95,38% sequence identity for the envelope glycoprotein GP5, which bears a major neutralizing epitope) in order test the influence of elevated Zn levels on an suboptimal antigen stimulus and on crossprotection. Elevated dietary zinc oxide levels do not have a substantial effect on porcine reproductive and respiratory syndrome virus (PPRSV) vaccination and infection	./cache/cord-333349-tsfxpaj6.txt	./txt/cord-333349-tsfxpaj6.txt