id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305315-0qt7eth0	Cao, Liyan	Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway	2015-08-18		.txt	text/plain	4245	277	53	title: Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway In this study, porcine small intestinal epithelial cells (IECs), the target cells of PEDV, were used as the infection model in vitro to identify the possible molecular mechanisms of PEDV-inhibition IFN-β production. CONCLUSION: Taken together, our data demonstrated for the first time that PEDV infection of its target cell line, IECs, inhibited dsRNA-mediated IFN-β production by blocking the activation of IPS-1 in RIG-I-mediated pathway. PEDV failed to induce IFN-β expression and inhibited poly (I:C)-mediated IFN-β production in IECs Type I IFNs (IFN-α/β) are critical to the host antiviral innate immune response. In summary, the findings of the present study suggested that PEDV-infection in IECs inhibits dsRNA-induced IFN-β induction by interfering with IRF-3 activity associated with RIG-I-mediated signaling pathway.	./cache/cord-305315-0qt7eth0.txt	./txt/cord-305315-0qt7eth0.txt