id author title date pages extension mime words sentences flesch summary cache txt cord-300434-obvm2en0 Ivancic-Jelecki, Jelena Variability analysis and inter-genotype comparison of human respiratory syncytial virus small hydrophobic gene 2018-07-18 .txt text/plain 4815 260 56 BACKGROUND: Small hydrophobic (SH) gene is one of the mostly diverse genomic regions of human respiratory syncytial virus (HRSV). When analysis was restricted to strains with identical HVR2 nucleotide sequences and differing SH protein sequences, 75% of differences observed in the SH ectodomain were located within region coding for amino acids 49–51. In molecular epidemiology studies, HRSV surveillance and genotyping are based on sequences of the second, C-terminal hypervariable region of the G gene (HVR2). Following our previous analysis of HVR2 sequences of strains detected within a limited geographical area (the Zagreb region) and limited time frame (March 2011 to March 2014) [16] , the goal of this study was to investigate whether virus variability and inter-genotype differences observed for HVR2 are also present in the SH gene. ./cache/cord-300434-obvm2en0.txt ./txt/cord-300434-obvm2en0.txt