id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289397-a1cuq29o	Liu, Jiangning	Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication	2011-10-27		.txt	text/plain	4068	218	52	Lycorine treatment of mice challenged with a lethal dose of EV71 resulted in reduction of mortality, clinical scores and pathological changes in the muscles of mice, which were achieved through inhibition of viral replication. To study the inhibitory mechanism of lycorine against EV71 infection, the synthesis of several typical viral proteins were detected by western blotting in 1.5 hours periods following lycorine treatment, when the effects of inhibition was just appeared ( Figure 3A and 3B) . Consistent with the results of the clinical scores and survival rates, virus replication in the muscle of lycorine-treated mice were inhibited by 10-100 folds at different time points compared to that of the saline control as detected by qRT-PCR and semi-quantitative RT-PCR ( Figure 5A and 5B). The virus replication in muscle tissues of lycorine-treated (0.4 mg/kg) mice was significantly inhibited by more than 100-fold compared to the saline control as detected by qRT-PCR and semiquantitative RT-PCR ( Figure 7A and 7B) .	./cache/cord-289397-a1cuq29o.txt	./txt/cord-289397-a1cuq29o.txt