id author title date pages extension mime words sentences flesch summary cache txt cord-286256-yol03hid Xu, Tian-min Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: a case report 2020-06-19 .txt text/plain 1177 76 56 title: Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: a case report BACKGROUND: Convalescent plasma (CP) transfusion was reported to be effective in treating critically ill patients with COVID-19, and hydroxychloroquine could potently inhibit SARS-CoV-2 in vitro. CASE PRESENTATION: Laboratory findings showed high lactic acid level (2.1 mmol/L) and C-reactive protein (CRP, 48.8 mg/L), and low white blood cell count (1.96 × 10(9)/L) in a 65-year-old Chinese man, who was diagnosed with severe COVID-19. The lactic acid and C-reactive protein levels remained high (2.1 mmol/L and 73.23 mg/L, respectively), while the arterial oxyhemoglobin saturation decreased to 86% with a low oxygenation index (OI, 76 mmHg) on day 4 after CP transfusion. Few studies have reported the effectiveness of convalescent plasma (CP) transfusion in treating critically ill patients with COVID-19 [2] [3] [4] . Herein, we administered CP transfusion and hydroxychloroquine to a patient with severe COVID-19, and analyzed their clinical symptoms, oxygenation index (OI), and dynamics of viral load. ./cache/cord-286256-yol03hid.txt ./txt/cord-286256-yol03hid.txt