id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271868-giea69b5	Firth, Andrew E	A case for a CUG-initiated coding sequence overlapping torovirus ORF1a and encoding a novel 30 kDa product	2009-09-08		.txt	text/plain	2339	128	53	These viruses have a linear positive-sense ssRNA genome of ~25-30 kb, encoding a large polyprotein that is expressed from the genomic RNA, and several additional proteins expressed from a nested set of 3'-coterminal subgenomic RNAs. In this brief report, we describe the bioinformatic discovery of a new, apparently coding, ORF that overlaps the 5' end of the polyprotein coding sequence, ORF1a, in the +2 reading frame. As with other members of the order Nidovirales, these viruses have a linear positive-sense ssRNA genome encoding a large replicase polyprotein that is expressed from the genomic RNA (ORF1a and, via ribosomal frameshifting, an ORF1a-ORF1b fusion product), and a number of other proteinsincluding the structural proteins -which are translated from a nested set of 3'-coterminal sub-genomic RNAs ( Figure 1A ) [1] [2] [3] [4] [5] [6] .	./cache/cord-271868-giea69b5.txt	./txt/cord-271868-giea69b5.txt