id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268560-pwps783y	Garrido, Jose L	EBNA3C interacts with Gadd34 and counteracts the unfolded protein response	2009-12-29		.txt	text/plain	5043	238	45	In B-cells, Gadd34, and EBNA3C are present in a complex with PP1a using microcystin sepharose affinity purification, Using a lymphoblastoid cell line in which EBNA3C protein levels are conditional on hydroxytamoxifen, surprisingly, we found that (i) EBNA3C maintains phosphorylation of eIF2α at serine 51, and (ii) protects against ER stress induced activation of the unfolded protein response as measured by XBP1 (u) versus XBP1(s) protein expression and N-terminal ATF6 cleavage. Recombinant EBV containing a stop codon in the EBNA3C ORF is able to cause B-cell transformation only when transcomplemented for wildtype EBNA3C either in cis or trans, and LCLs immortal-ized by recombinant EBV containing a conditional EBNA3C gene, undergo growth arrest when EBNA3C expression is turned off [5] [6] [7] EBNA3C co-activates transcription with EBNA2 at the viral LMP-1 promoter, as well as heterologous reporter systems designed to test p300 function.	./cache/cord-268560-pwps783y.txt	./txt/cord-268560-pwps783y.txt