id author title date pages extension mime words sentences flesch summary cache txt cord-011880-qlutgfu2 Barberis, Abdelheq Full-length genome sequences of the first H9N2 avian influenza viruses isolated in the Northeast of Algeria 2020-07-17 .txt text/plain 7502 380 49 In addition, different studies, showed that circulating H9N2 strains have acquired affinity to mammalian like-receptors and gained high virulence and pathogenicity through substitutions in their viral proteins [13, 14] ; the most known substitutions are in the HA protein that promotes virus binding to cellular receptors. While the substitution 627 K that confers high pathogenicity, virulence and increased replication in mice [63] , was not detected in our Algerian viruses, three substitutions 318R, 590S and 661 T, associated with mammalian adaptation, were observed [71, 72] . The PB1 substitutions N105S, K577E/M and 578Q, known to be associated with increased polymerase activity, H9N2 pathogenicity in mice as well as adaptation to mammalians [61, 64, 78] , were not observed in the currently circulating Algerian strains, which however shared 105 N, 577 K and 578 K. Amino acids analysis showed that the Algerians H9N2 strains carried out different molecular markers associated with affinity to human-like receptors and increased virulence. ./cache/cord-011880-qlutgfu2.txt ./txt/cord-011880-qlutgfu2.txt