id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000990-ci6db90d	Guo, Ling	Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca)	2013-05-26		.txt	text/plain	2761	152	54	BACKGROUND: In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus. Canine parvovirus type 2a/2b having mutation at 297 residue (Ser→Ala) is designated as new CPV-2a/2b [8, 9] , residue 297 is located in a minor antigenic site close to epitope B and substitutions at this position may be responsible for changes in antigenicity of CPV variants [10] . In comparison to prototype new-CPV-2a (AY742953), the samples under this study had amino acid residue variations at Tyr324Ile caused by mutation TAT →ATT at nt 3756-3758 of the VP2 gene.	./cache/cord-000990-ci6db90d.txt	./txt/cord-000990-ci6db90d.txt