id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-033692-txfuuu7d	Lim, Byeonghwi	Integrated time-serial transcriptome networks reveal common innate and tissue-specific adaptive immune responses to PRRSV infection	2020-10-13		.txt	text/plain	7927	371	44	In this study, we investigated the molecular mechanisms of PRRSV infection by integrating the differences in the expression of various genes in tissues responsible for respiration (lungs) and immunity (bronchial lymph nodes [BLNs] , and tonsils) using RNA-Seq data at serial time points. To validate the results of specific groups, GSEA based on the KEGG database were performed using log 2 -normalised TMM counts at each time point for each tissue to identify the maximum gene expression changes for each group, and the GSEA results were consistent with the KEGG enrichment analyses of DEGs. GSEA using the 3-dpi data for all tissues revealed many significant pathways related to viral infection, among which influenza A showed the highest NES ( Figure 5A ). Significant KEGG terms related to viral infections and immune signalling were identified through KEGG enrichment analyses performed for each up-and down-regulated genes (343 and 287 genes, respectively), based on the time point for each tissue with a maximum FC value in the GCN, which was constructed using serial DEGs ( Figure 4A ).	./cache/cord-033692-txfuuu7d.txt	./txt/cord-033692-txfuuu7d.txt